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Cinthia Alves Barroco is Ph.D. in Molecular Biology - FCT/NOVA. The main research interest is to understand the dynamics of populations of bacterial pathogens of human and animal origin, and the molecular mechanisms involved in pathogen adaptation and virulence. Research activities include Analysis of whole-genome sequences of bacteria from different niches, clinical origins, and hosts to retrieve their phylogenetic structure, accessory genes, and potential for horizontal gene transfer of phages and of another mobile genetic element that influences the pathogenicity of isolates; Study of antimicrobial resistance patterns and underlying molecular mechanisms; The study of the ability of drugs/treatment strategies using nanotechnology for to eradicate the bacterial biofilms; Investigation of mechanisms the infection mechanisms of bacteria in human cells by proteomic analysis to study and identify pathways in the host cell that respond to exposure to specific pathogens.
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Identification

Personal identification

Full name
Cinthia Alves Barroco

Citation names

  • Alves-Barroco, Cinthia

Author identifiers

Ciência ID
AD15-0560-2F92
ORCID iD
0000-0002-3526-0780

Email addresses

  • c.barroco@campus.fct.unl.pt (Professional)
  • caabarroco@gmail.com (Personal)

Addresses

  • Centro de Recursos Microbiológicos, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa . Quinta da Torre, 2829-516 M, Setúbal, Almada, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Molecular Biology
Education
Degree Classification
2022
Concluded
 Biologia (Doutoramento)
Major in Molecular Biology
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Unraveling the host specificity within Streptococcus dysgalactiae subsp. dysgalactiae" (THESIS/DISSERTATION)
2013
Concluded
 Microbiologia Aplicada (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Antibioresistência e pesquisa de factores de virulência em Aeromonas spp." (THESIS/DISSERTATION)
2010
Concluded
 Biologia com especialização em Biologia Molecular e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a " (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2024/01 - Current Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/03 - 2023/10 Researcher (Research) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2014/03/01 - 2022/12 Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2019/04/01 - 2019/07/01 Visiting Researcher (Research) Universidade Federal do Rio de Janeiro Instituto de Microbiologia Professor Paulo de Góes, Brazil
Projects

Grant

Designation Funders
2017 - 2021 Unraveling the host specificity within pyogenic streptococci
SFRH/BD/118350/2016
PhD Student Fellow
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/03/20 - Current authEntic cheesoMics: from big data, through labOratory, towards the fuTure of protected desIgnation of OrigiN
PTDC/OCE-ETA/1785/2020
Research Fellow
Ongoing
2016/09 - 2019/09 Unveiling host specificity and host-pathogen interactions of Streptococcus.
PTDC/CVT-EPI/6685/2014
Researcher
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2014 - 2015 Unraveling the host specificity within Streptococcus dysgalactiae subsp dysgalactiae
PTDC/CVT-EPI/4651/2012
Researcher
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Mariana Nascimento; Alves-Barroco, Cinthia; F. Silva; R. Mato; R. Dias; R. Tenreiro and Ilda Santos-Sanches.. "A quest for lysogenic bacteriophages in Streptococcus dysgalactiae subsp. dysgalactiae". Paper presented in Portuguese Congress of Microbiology and Biotechnology. Microbiotec17., Lisbon, 2017.
  2. Alexandre Almeida; Alves-Barroco, Cinthia; E. Sauvage; R. Bexiga; P. Albuquerque F. Tavares; I. Santos-Sanches and P. Glaser. "A single clonal lineage of group b Streptococcus is causing bovine mastitis in the north of portugal". Paper presented in IMMEM 2016; 11th International Meeting on Microbial Epidemiological Markers, Lisbon, 2016.
Conference paper
  1. Catarina Roma-Rodrigues, Luís R. Raposo, Ana Pontes, Ana P. Rodrigo, Bárbara Gonçalves, Beatriz Oliveira, Carla Gonçalve; Alves-Barroco, Cinthia; ristiano Mota, Daniela Ferreira, Diana O. Ribeiro, Filipa Trovão, Inês Gonçalves, Inês Grilo, Joana Bugalhão, João P. Gu. "FCT-NOVA strengthened National adult day-care testing in the beginning of COVID-19 outbreak". Lisbon, 2022.
Conference poster
  1. S. Serrano; M. V. Ferreira; Alves-Barroco, Cinthia; M. T. Barreto-Crespo ; T. Semedo-Lemsaddek. Corresponding author: T. Semedo-Lemsaddek. "Enterococcal community in traditional PDO cheeses: a roadmap on antibiotic resistance over the years". Paper presented in The 2nd International Electronic conference on Microbiology. https://ecm2023.sciforum.net/, Online conference, 2023.
  2. M. V. Ferreira; Alves-Barroco, Cinthia; M. T. Barreto-Crespo; T. Semedo-Lemsaddek. Corresponding author: T. Semedo-Lemsaddek. "Traditional cheeses as bio-factories for probiotic bacteria". Paper presented in Congress of Microbiology and Biotechnology, MICROBIOTEC 2023, 2023.
  3. Alves-Barroco, Cinthia; Patricia H. Brito; Alexandra R. Fernandes. "Phylogenomics and accessory genome diversity of Streptococcus dysgalactiae uncover host specializations". Paper presented in Meeting of the International Society for Evolution, Medicine and Public Health, 2022.
  4. Paquete-Ferreira, J.; Alves-Barroco, Cinthia; Santos-Silva, T. ; Fernandes, A.R. "Expression and structure of BrpA produced by Streptococcus dysgalactiae subsp dysgalactiae". Paper presented in ECCMID 2021, 2021.
  5. Alves-Barroco, Cinthia; Santos-Sanches, I; Fernandes, A.R.. "Genetic characterization of the locus for streptolysin S from Streptococcus dysgalactiae". 2021.
  6. Alves-Barroco, Cinthia; Maria Alexandra Ramos Fernandes. "Expression of biofilm-associated gene of Streptococcus dysgalactiae subsp. dysgalactiae from bovine mastitis.". Paper presented in IMPSG-2020 International Meeting of the Portuguese Society of Genetics., 2020.
  7. Alves-Barroco, Cinthia; Maria Alexandra Ramos Fernandes; Baptista, Pedro Viana; Lorenzo Rivas-García. "Gold-silver alloy nanoparticles modulate expression of genes involved in biofilm formation by S. dysgalactiae subsp. dysgalactiae from bovine mastitis". Paper presented in IMPSG-2020 International Meeting of the Portuguese Society of Genetics., 2020.
  8. Alves-Barroco, Cinthia; Rosario Mato. "Diversity of the CRISPR IIA locus of Streptococcus dysgalactiae subsp dysgalactiae". Paper presented in IMPSG-2020 International Meeting of the Portuguese Society of Genetics, 2020.
  9. Alves-Barroco, Cinthia; A. Maria Nunes Botelho; C. Roma-Rodrigues; M. Aparecida Guimarães; M Antonio Americo; J. Muthukumaran; T. Santos-Silva;; Maria Alexandra Ramos Fernandes. "In vitro and in vivo models to study biofilm formation by Streptococcus dysgalactiae subsp. dysgalactiae". Paper presented in 30th Brazilian Congress of Microbiology, 2019.
  10. Alves-Barroco, Cinthia; C. Roma-Rodrigues; L.R. Raposo; C. Brás; M. Diniz; J. Caço; P. M. Costa; I. Santos-Sanches; Maria Alexandra Ramos Fernandes. "Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: in vitro and in vivo infection of human cells and zebrafish (Danio rerio) as biological models.". Paper presented in Portuguese Congress of Microbiology and Biotechnology. Microbiotec17., 2017.
  11. Alves-Barroco, Cinthia; M. Severo Ramundo; R. Mato; R. Bexiga; B. Ferreira-Carvalho;A. M. Figueiredo; and I. Santos Sanches.. "Capsular polysaccharide (cps) typing of streptococcus agalactiae from bovine mastitis.". Paper presented in XL Jornadas Portuguesas de Genética., 2016.
  12. Alves-Barroco, Cinthia; C. Roma-Rodrigues; M. Dinis; A. R. Fernandes and I. Santos Sanches.. "In vitro and in vivo examination of S. dysgalactiae subsp. dysgalactiae virulence and host-pathogen interactions using human cells and zebrafish (Danio rerio) as biological models.". Paper presented in 2º Genetics Workshop. Lisbon, Portugal., 2016.
  13. Alves-Barroco, Cinthia; M. Severo Ramundo R. Mato; R. Bexiga; B. T. Ferreira-Carvalho; A. M. Figueiredo; and I. Santos Sanches.. "Capsular genotyping of bovine mastitis Streptococcus agalactiae (group b Streptococcus, gbs) based on sequences of the capsular polysaccharide gene (cps) cluster.". Paper presented in ECCMID 2016. 26th European Congress of Clinical Microbiology and Infectious Diseases., 2016.
  14. Alves-Barroco, Cinthia; J. Caço; C. Roma-Rodrigues; N. Balasubramanian; R. Mato; A. R. Fernandes; L. Chambel; R. Tenreiro and I. Santos Sanches.. "Evolution of bovine mastitis Streptococcus dysgalactiae subsp. dysgalactiae isolates from portugal". Paper presented in Portuguese Congress of Microbiology and Biotechnology. Microbiotec15., 2015.
  15. Alves-Barroco, Cinthia; Catarina Roma-Rodrigues; J. Caço; L.R. Raposo; M.N. Costa; E. Fortunao; P.V. Baptista; A. R. Fernandes and I. Santos Sanches.. "Analysis of adherence to and internalization into human cells by bovine mastitis Streptococcus dysgalactiae subsp. dysgalactiae.". Paper presented in Portuguese Congress of Microbiology and Biotechnology. Microbiotec15., 2015.
  16. Alves-Barroco, Cinthia. "Phenotypic and genotypic characterization of Corynebacterium pseudotuberculosis isolates from caseous lymphadenitis in black alentejano pig.". Paper presented in Portuguese Congress of Microbiology and Biotechnology. Microbiotec15, 2015.
  17. Alves-Barroco, Cinthia; M. Aparecida Guimarães; N. Balasubramanian; B.T. Ferreira-Carvalho; A.M.S. Figueiredo and I. Santos-Sanches.. "Biofilm-forming ability of Streptococcus dysgalactiae subsp. dysgalactiae from bovine infections and assessment of biofilm regulatory genes lytA and brpA.". Paper presented in XIX Lancefield International Symposium on Streptococci and Streptococcal Diseases, 2014.
  18. Alves-Barroco, Cinthia; C. Correia; M.T. Barreto-Crespo; A.S. Barreto and T. Semedo-Lemsaddek.. "Screening for virulence factors in Aeromonas spp.: is pcr amplification a reliable method?". Paper presented in 11th International Symposium on Aeromonas and Plesiomonas, 2014.
  19. Alves-Barroco, Cinthia; C. Correia; M.T. Barreto-Crespo; A.L. Simplício; A.S. Barreto and T. Semedo-Lemsaddek.. "Evaluation of the pathogenic potential of Aeromonas spp. strains isolated from water, food and food processing surfaces.". Paper presented in 11th International Symposium on Aeromonas and Plesiomonas, 2014.
  20. Ana Quendera; Alves-Barroco, Cinthia; C. Varela; A.S. Barreto and T. Semedo-Lemsaddek.. "In vitro antibacterial activity of commercial essential oils against multiresistant aeromonads.". Paper presented in 11th International Symposium on Aeromonas and Plesiomonas, 2014.
  21. Alves-Barroco, Cinthia; Mottola C.; Mendes J.; Melo-Cristino J.; Cavaco-Silva P.; Tavares L.; Oliveira M.; Semedo-Lemsaddek T.. "Hemolytic multi-drug resistant enterococci from diabetic foot ulcers". Paper presented in European Congress of Clinical Microbiology and Infectious Diseases, 2014.
  22. Semedo-Lemsaddek T. Ribeiro T.; Fernandes A.;; Alves-Barroco, Cinthia; Mottola C.; Seixas R.; Tavares L.; Bernardo F. and Oliveira M.. "Do enterococci from intensive and extensive farming broilers constitute a risk for food safety?". Paper presented in VI Congresso de Ciências Veterinárias, 2014.
  23. Alves-Barroco, Cinthia; Craveiro S.; Barreto-Crespo T.; Barreto; A.S.; Semedo-Lemsaddek T.; Semedo-Lemsaddek T.. Corresponding author: Semedo-Lemsaddek T.. "Virulence traits among Aeromonas isolated from water, food and food-related environments". Paper presented in Portuguese Congress of Microbiology and Biotechnology, 2013.
  24. S. Craveiro; Alves-Barroco, Cinthia; Barreto-Crespo T.; Barreto; A.S.; Semedo-Lemsaddek T.. "Aeromonas biofilm-formation on stainless steel coupons". Paper presented in Portuguese Congress of Microbiology and Biotechnology, 2013.
  25. S. Craveiro; Alves-Barroco, Cinthia; Barreto-Crespo T.; Barreto; A.S.; Semedo-Lemsaddek T.. "Microbial diversity of Aeromonas spp. using multilocus sequence analysis". Paper presented in Portuguese Congress of Microbiology and Biotechnology, 2013.
  26. Santos V.; Alho M.;; Alves-Barroco, Cinthia; Barreto A.S and T. Semedo-Lemsaddek. "High prevalence of multidrug-resistant food related enterococci". Paper presented in The II International Conference on Antimicrobial Research – ICAR, 2012.
  27. Alves-Barroco, Cinthia; Craveiro S.; Santos V.; Alho M.; Barreto-Crespo T.; Barreto; A.S. and Semedo-Lemsaddek. "AEROMONADS: reservoirs of antibiotic resistance determinants.". Paper presented in The II International Conference on Antimicrobial Research – ICAR, 2012.
  28. Mafalda Alho; Alves-Barroco, Cinthia; Santos V.; Barreto A.S and T. Semedo-Lemsaddek.. "Emergence of resistant Listeria spp.: a big concern for public health". Paper presented in The II International Conference on Antimicrobial Research – ICAR, 2012.
  29. Alves-Barroco, Cinthia; Craveiro S.; Santos V.; Alho M.; Barreto-Crespo T.; Barreto; A.S.; Semedo-Lemsaddek T. "AEROMONAS-TOXINFECTIONS: an underestimated pathogen.". Paper presented in Addressing Global Food Security and Wellness through Food Science and Technology., 2012.
  30. Mafalda Alho; Alves-Barroco, Cinthia; Santos V.; Barreto A.S and T. Semedo-Lemsaddek.. "Are Listeria spp. present in food and food-processing surfaces similar to clinical isolates?". Paper presented in Addressing Global Food Security and Wellness through Food Science and Technology, 2012.
  31. Veronica Santos; Mafalda Alho; Alves-Barroco, Cinthia; Barreto A.S and T. Semedo-Lemsaddek.. "Microbial diversity and antibiotic resistance among enterococci isolated from food and food-processing surfaces.". Paper presented in Addressing Global Food Security and Wellness through Food Science and Technology, 2012.
Journal article
  1. Alves-Barroco, Cinthia; Botelho, Ana Maria Nunes; Américo, Marco Antonio; Fracalanzza, Sérgio Eduardo Longo; de Matos, António P. Alves; Guimaraes, Márcia Aparecida; Ferreira-Carvalho, Bernadete Teixeira; Figueiredo, Agnes Marie Sá; Fernandes, Alexandra R.. "Assessing in vivo and in vitro biofilm development by Streptococcus dysgalactiae subsp. dysgalactiae using a murine model of catheter-associated biofilm and human keratinocyte cell". Frontiers in Cellular and Infection Microbiology 12 (2022): http://dx.doi.org/10.3389/fcimb.2022.874694.
    10.3389/fcimb.2022.874694
  2. Alves-Barroco, Cinthia; Brito, Patrícia H.; Santos-Sanches, Ilda; Fernandes, Alexandra R.. "Phylogenetic analysis and accessory genome diversity reveal insight into the evolutionary history of Streptococcus dysgalactiae". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.952110.
    10.3389/fmicb.2022.952110
  3. Alves-Barroco, Cinthia; Rivas-García, Lorenzo; Fernandes, Alexandra R.; Baptista, Pedro Viana. "Light Triggered Enhancement of Antibiotic Efficacy in Biofilm Elimination Mediated by Gold-Silver Alloy Nanoparticles". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.841124.
    10.3389/fmicb.2022.841124
  4. Alves-Barroco, Cinthia; Caço, João; Roma-Rodrigues, Catarina; Fernandes, Alexandra R.; Bexiga, Ricardo; Oliveira, Manuela; Chambel, Lélia; et al. "New Insights on Streptococcus dysgalactiae subsp. dysgalactiae Isolates". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.686413.
    10.3389/fmicb.2021.686413
  5. Alves-Barroco, Cinthia; Paquete-Ferreira, João; Santos-Silva, Teresa; Fernandes, Alexandra R.. "Singularities of Pyogenic Streptococcal Biofilms From Formation to Health Implication". Frontiers in Microbiology 11 584947 (2020): http://dx.doi.org/10.3389/fmicb.2020.584947.
    Open access • 10.3389/fmicb.2020.584947
  6. Alves-Barroco, Cinthia; Rivas-García, Lorenzo; Fernandes, Alexandra R.; Baptista, Pedro Viana. "Tackling Multidrug Resistance in Streptococci From Novel Biotherapeutic Strategies to Nanomedicines". Frontiers in Microbiology 11 579916 (2020): http://dx.doi.org/10.3389/fmicb.2020.579916.
    Open access • Published • 10.3389/fmicb.2020.579916
  7. Alves-Barroco, Cinthia; Roma-Rodrigues, Catarina; Balasubramanian, Natesan; Guimarães, Marcia Aparecida; Ferreira-Carvalho, Bernadete T.; Muthukumaran, Jayaraman; Nunes, Daniela; et al. "Biofilm development and computational screening for new putative inhibitors of a homolog of the regulatory protein BrpA in Streptococcus dysgalactiae subsp. dysgalactiae". International Journal of Medical Microbiology 309 3-4 (2019): 169-181. http://dx.doi.org/10.1016/j.ijmm.2019.02.001.
    10.1016/j.ijmm.2019.02.001
  8. Florindo, Carlos; Barroco, Cinthia Alves; Silvestre, Inês; Damião, Vera; Gomes, João Paulo; Spellerberg, Barbara; Santos-Sanches, Ilda; Borrego, Maria José. "Capsular Type, Sequence Type and Microbial Resistance Factors Impact on DNase Activity of Streptococcus agalactiae Strains from Human and Bovine Origin". European Journal of Microbiology and Immunology 8 4 (2018): 149-154. http://dx.doi.org/10.1556/1886.2018.00026.
    10.1556/1886.2018.00026
  9. Alves-Barroco, Cinthia; Roma-Rodrigues, Catarina; Raposo, Luís R.; Brás, Catarina; Diniz, Mário; Caço, João; Costa, Pedro M.; Santos-Sanches, Ilda; Fernandes, Alexandra R.. "Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: In vitro and in vivo infection of human cells and zebrafish as biological models". MicrobiologyOpen 8 1 (2018): e00623. http://dx.doi.org/10.1002/mbo3.623.
    10.1002/mbo3.623
  10. Almeida, Alexandre; Alves-Barroco, Cinthia; Sauvage, Elisabeth; Bexiga, Ricardo; Albuquerque, Pedro; Tavares, Fernando; Santos-Sanches, Ilda; Glaser, Philippe. "Persistence of a dominant bovine lineage of group B Streptococcus reveals genomic signatures of host adaptation". Environmental Microbiology 18 11 (2016): 4216-4229. http://dx.doi.org/10.1111/1462-2920.13550.
    10.1111/1462-2920.13550
  11. Semedo-Lemsaddek, Teresa; Mottola, Carla; Alves-Barroco, Cinthia; Cavaco-Silva, Patrícia; Tavares, Luís; Oliveira, Manuela. "Characterization of multidrug-resistant diabetic foot ulcer enterococci". Enfermedades Infecciosas y Microbiología Clínica 34 2 (2016): 114-116. http://dx.doi.org/10.1016/j.eimc.2015.01.007.
    10.1016/j.eimc.2015.01.007
  12. Alves-Barroco, Cinthia; Roma-Rodrigues, Catarina; Raposo, Luís R.; Costa, Mafalda N.; Fortunato, Elvira; Baptista, Pedro Viana; Fernandes, Alexandra R.; Santos-Sanches, Ilda. "Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder". Microbes Infect 18 4 (2016): 290-293. http://www.ncbi.nlm.nih.gov/pubmed/26655883.
    doi: 10.1016/j.micinf.2015.11.005.
  13. Craveiro, Sara; Alves-Barroco, Cinthia; Barreto Crespo, Maria Teresa; Salvador Barreto, António; Semedo-Lemsaddek, Teresa. "Aeromonas biofilm on stainless steel: efficiency of commonly used disinfectants". International Journal of Food Science & Technology 50 4 (2015): 851-856. http://dx.doi.org/10.1111/ijfs.12731.
    10.1111/ijfs.12731
  14. Oliveira, Manuela; Alves-Barroco, Cinthia; Mottola, Carla; Santos, Raquel; Lemsaddek, Abdelhak; Tavares, Luis; Semedo-Lemsaddek, Teresa. "First report of Corynebacterium pseudotuberculosis from caseous lymphadenitis lesions in Black Alentejano pig (Sus scrofa domesticus)". BMC Veterinary Research 10 1 (2014): http://dx.doi.org/10.1186/s12917-014-0218-3.
    Published • 10.1186/s12917-014-0218-3
Newsletter article
  1. Alves-Barroco, Cinthia. "Águas tempestuosas: efeitos da presença de Aeromonas spp.", Boletim de Biotecnologia: Sociedade Portuguesa de Biotecnologia, S. 2, N. 6. pag 35-37., 2015
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/09/23 In vivo and in vitro biofilm formation by Streptococcus dysgalactiae subsp. dysgalactiae UCIBIO annual meeting
Applied Molecular Biosciences Unit - UCIBIO
2014/11/12 Biofilm-forming ability of Streptococcus dysgalactiae subsp. dysgalactiae from bovine infections and assessment of biofilm regulatory genes lytA and brpA
Lancefield International Symposium on Streptococci and Streptococcal Diseases (Buenos Aires , Argentina)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2017 - 2022 Participation of the activity of the Human Genetics and Cancer Therapeutics group - "Qual a melhor terapia para o cancro" (Which is the best cancer therapeutics?)
Exhibition
 EXPO-FCT
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2014 - 2016 Organization and participation of the activity "Molecular Epidemiology and Genetics of Gram-Positive Bacteria"
Exhibition
 EXPO-FCT
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Association member

Society Organization name Role
2016 - Current Sociedade Portuguesa de Genética
2013 - Current Sociedade Portuguesa de Microbiologia