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Degree in Biochemistry, Faculty of Sciences, University of Lisbon, Portugal (1993-1999). Graduation Thesis "Genetics of Familial Ademonate Polyposis" Portuguese Institute of Oncology Francisco Gentil Lisbon. PhD in Biomedical Sciences, speciality in Medical Parasitology (2002-2007). Thesis on "Genetics of artemisinin resistance in malaria using the malaria animal model" Malaria and other Tropical Diseases Centre, Institute of Hygiene and Tropical Medicine Lisbon. Post-Doctorate in the project "Genetics of Praziquantel resistance in Schistosoma mansoni" (2007-2009), Institute of Hygiene and Tropical Medicine Lisbon Contract as Auxiliary Researcher Helminthology and Medical Malacology Group, Teaching and Research Unit in Medical Parasitology, Institute of Hygiene and Tropical Medicine, Lisbon (2009-2013) Post-Graduation in International Health and Development at the Institute of Hygiene and Tropical Medicine, New University of Lisbon. Science Without Borders Young Talent Scholarship " Study of Praziquantel drug-resistance in schistosomiasis mansoni genetics, proteomics and transcriptomics" University of São Paulo and Federal University of São Carlos, Brazil (2014-2019) 2017-2018 Master in Clinical Trials and Medical Affairs. Centro de Estudos Superiores da Industria Farmacêutica, Master Thesis Preparation of a therapeutic value dossier: Benralizumab Since 2020 contract researcher in the Merino Parasite project. The main objective of this project is to identify genetic markers associated with resistance to internal parasites that can be applied in the improvement of the Merino White breed. To this end, it is intended to compare the genotype of sheep resistant to parasites with the genotype of susceptible animals. The resistance to parasites will be evaluated with a panel of phenotypic characteristics. Other objectives include the epidemiological study of parasite species prevalent in sheep in different agroclimatic areas and the evaluation of parasite resistance to anthelmintics. Distance learning with Brazil and Africa. Current area of expertise: Medical Helminthology and Malacology in particular associated with drug resistance namely Praziquantel in the case of schistosomiasis Fields of expertise and current research interests: Drug pressure selection process, Praziquantel resistance in Schistosoma mansoni animal model Molecular epidemiology of anthelmintic resistance Research of new phytotherapeutic compounds applied in schistosomiasis control. Bioecology and population dynamics of the parasite Schistosoma mansoni. Application of molecular techniques for identification of the resistance locus to Praziquantel. Molecular biology. Physiology. Medicine. Animal models. Clinical trials.
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Identification

Personal identification

Full name
Ana Júlia Pinto Fonseca Sieuve Afonso
Date of birth
1974/11/08
Gender
Female

Citation names

  • Afonso, Ana
  • Afonso A
  • Ana Júlia Pinto Fonseca Sieuve Afonso
  • A J P F S Afonso
  • Afonso, A J P F S
  • Afonso, A
  • Ana Afonso
  • Afonso, Ana Júlia Pinto Fonseca Sieuve
  • Afonso, A. J. P. F. S.

Author identifiers

Ciência ID
AA16-F0E3-C077
ORCID iD
0000-0002-8476-1346
Google Scholar ID
https://scholar.google.com/citations?user=qiTcOBkAAAAJ&hl=pt-PT&oi=ao
Researcher Id
K-1023-2015
Scopus Author Id
57211619965

Email addresses

  • anaafonso74@hotmail.com (Professional)
  • aafonso@ihmt.unl.pt (Professional)
  • julia.afonso@iniav.pt (Professional)
  • anajuliaafonso74@gmail.com (Personal)

Telephones

Fax
  • 214 416 01 (Professional)
Telephone
  • 214 403 50 Ext.: 62032 (Professional)

Addresses

  • Av. da República, Quinta do Marquês (edifício sede), 2780-157, Oeiras, Oeiras, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Parasitology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Health Sciences - Tropical Medicine
  • Agrarian Sciences - Veterinary Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2017/09 - 2018/11
Concluded
 Clinical Trials and Medical Affairs (Mestrado)
Major in Ensaios Clínicos e Medical Affairs
Centro de Estudos Avançados da Industria Farmacêutica, Portugal
"Elaboração de um dossier de valor terapêutico: Benralizumab " (THESIS/DISSERTATION)
 17 valores
2012/09 - 2013/09
Concluded
 Saúde Pública e Desenvolvimento (Mestrado integrado)
Major in Gestão de Programas
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 18 valores
2002/09 - 2007/11
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Especialidade: Parasitologia
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
"Studies on the Genetics of Artemisinin Resistance in Malaria" (THESIS/DISSERTATION)
 Uninimidade, Distinção, Louvor
1993/09 - 1998/09
Concluded
 Bioquímica (Licenciatura)
Major in Bioquímica
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
"Diagnóstico genético do síndroma de Lynch, deteção de mutações nos genes de reparação do DNA: hMLH1 e hMSH2 " (THESIS/DISSERTATION)
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2020/01/02 - Current Researcher (Research) Instituto Nacional de Investigação Agrária e Veterinária, Portugal
Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2014/01 - 2019/12 Visiting Researcher (Research) Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2008/09 - 2014/07 Invited Assistant Professor (University Teacher) Universidade Atlântica Escola Superior de Saúde Atlântica, Portugal
Universidade Atlântica Escola Superior de Saúde Atlântica, Portugal
2010/09 - 2011/07 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2008/09 - 2010/07 Invited Adjunct Teacher (Polytechnic Teacher) Escola Superior de Tecnologias e Artes de Lisboa, Portugal
Escola Superior de Tecnologias e Artes de Lisboa, Portugal

Others

Category
Host institution 		Employer
2014/01/01 - 2017/12/31 Invited researcher and Invited professor, “Young Talent Scientist” Fellowship from CNPq Brazil – Level A. Researcher responsible for coordinating financially and scientifically the research project. Universidade de São Paulo Instituto de Química de São Carlos, Brazil
Universidade de São Paulo Instituto de Química de São Carlos, Brazil
(...)
2009/07/01 - 2013/12/31 C2008-Post Doctoral Research Position as a Researcher Assistant in Biotechnology (PM-BIOT-2008)/UPMM/IHMT/UNL. Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007/09 - 2009/07 Professora do ensino secundário - disciplina de Biologia Colegio São João de Brito, Portugal
Colegio São João de Brito, Portugal
2007/11/01 - 2009/06/30 Pos Doctorate fellowship SFRH/BPD/26720/2006 Investigator of the project Genetics of accelerated acquisition of drug resistance to multiple drugs (ARMD) in malaria parasites: dynamics and fitness stud Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
(...)
2002/09/01 - 2007/10/31 PhD fellowship SFRH/BD/8913/2002, the title of the PhD thesis being “Genetics of artemisinin drug resistance in malaria”. Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2002/01/01 - 2002/08/31 Research assistant / Laboratory manager under the orientation of Professor Doctor Maria de Sousa, MD, PhD, Full Professor. Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1999/11/01 - 2001/12/31 Bolseira de Investigação: “Alterações genéticas e do ciclo celular no esófago de Barrett: evidência para uma origem clonal e efeito da terapêutica intensiva do refluxo” (PRAXIS/P/SAU/14142/98). Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
1998/09/01 - 1999/07/31 Estagiária de investigação no projecto: “Diagnóstico Genético do Síndroma de Lynch: carcinoma do cólon e reto não associado à polipose” Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
Projects

Contract

Designation Funders
2020/01 - Current Merino Parasites
PTDC/CVT-CVT/28798/2017
Researcher
Fundação para a Ciência e a Tecnologia, Portugal
Ongoing
2016/01 - 2018/12 Análise proteomica de Biomphalaria glabrata infectada por Schistosoma mansoni e Angiostrongylus cantonensis
FAPESP – Brasil – 2016/07137
Researcher
Universidade Estadual de Campinas Centro de Biologia Molecular e Engenharia Genética, Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2016/01 - 2018/12 Análise proteomica de Biomphalaria glabrata infectada por Schistosoma mansoni e Angiostrongylus cantonensis
FAPESP Brasil 2016/07137
 Fundação de Amparo à Pesquisa do Estado de São Paulo
2015 - 2018 Development of a blood vessel biomimetic in polyester toner fluidic microchip and evaluation of cell response against titanium oxide nanoparticules
IQSC-BioMics
Researcher
Universidade de São Paulo Instituto de Química de São Carlos, Brazil
 Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluded
2014/01 - 2017/12 Estudo da fármaco-resistência ao Praziquantel em esquistossomose mansónica - genética, proteómica e transcriptómica
MEC/MCTI/CAPES/CNPq/FAPs Nº 60/2011
Principal investigator
Universidade de São Paulo Instituto de Química de São Carlos, Brazil
 Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluded
2015 - 2016 Screening de fármacos semelhantes a chalconas e curcuminas no modelo do Caenorhabditis elegans
FAPESP, Proc no. 15/18745-8
Researcher
Universidade de Franca, Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2015 - 2016 Avaliação do efeito inibidor de fármacos de origem sintética em Biomphalaria glabrata na infeção por Schistosoma mansoni
FAPESP, Proc no. 14/12568-4
Researcher
Universidade Federal de São Carlos, Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2014 - 2016 Proteomica e bioprospecção dos efeitos da Mentha piperita L. durante a infecção experimental pelo Schistosoma mansoni
FAPESP, Proc no. 14/07331-5
Researcher
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2011/01 - 2015/12 Identification of new phytotherapeutic extracts against S. mansoni or their intermediate hosts (genera Biomphalaria and Bulinus) . - Drug Resistance to praziquantel
PEst-OE/SAU/UI0074/2014 – UPMM’s strategic projects, funded by the Portuguese foundation for science and technology (FCT).
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01 - 2015/12 Ecoepidemiologia de Dirofilaria spp: caracterização molecular, vectores potenciais e dinâmica de transmissão
PTDC/SAU-SAP/113523/2009
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01 - 2015/12 Identification of new phytotherapeutic extracts against S. mansoni or their intermediate hosts (genera Biomphalaria and Bulinus) . - Drug Resistance to praziquantel
PEst-OE/SAU/UI0074/2014 UPMMs strategic projects, funded by the Portuguese foundation for science and technology (FCT).
 Fundação para a Ciência e a Tecnologia
2006 - 2010 Identificação atempada dos determinantes biológicos e genéticos da resistência ao Tratamento Combinado à base de artemisinina em parasitas de malária
PTDC/SAU-MII/65028/2006
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Edinburgh Napier University Faculty of Health Life and Social Sciences, United Kingdom
Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2010 Estudos genéticos do fenótipo de resistência acelerada a múltiplos fármacos (ARMD) no parasita Plasmodium: dinâmica e estudos de fitness.
PTDC/BIA-MIC/65861/2006
Post-doc Fellow
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. Afonso, A. "Principais helmintoses negligenciadas ontem, hoje e amanhã no IHMT.". Lisboa, 2013.
    Published
  2. Afonso, A; Belo, Silvana; Mendes, Tiago Manuel Fernandes; Calado, Manuela; Ferreira, Pedro. "Immunological and genetically analysis of combined therapy with artemisinin-praziquantel in Schistosoma mansoni in vivo". Paper presented in Journal of Tropical Medicine and International Health, Barcelona, 2011.
    Published
  3. Afonso, A. "Immunological and genetically analysis of combined therapy with artemisinin-praziquantel in Schistosoma mansoni in vivo.". Paper presented in Tropical Medicine & International Health, Barcelona, 2011.
    Published
Journal article
  1. Mendes, Tiago Manuel Fernandes; Carrilho, Emanuel; Afonso, Ana Júlia Pinto Fonseca Sieuve; Galinaro, Carlos Alexandre; Cabral, Fernanda Janku; Allegretti, Silmara Marques. "Proteomic, metabolic and immunological changes in Biomphalaria glabrata infected with Schistosoma mansoni". International Journal for Parasitology 49 13-14 (2019): 1049-1060. http://dx.doi.org/10.1016/j.ijpara.2019.08.001.
    Open access • Published • 10.1016/j.ijpara.2019.08.001
  2. de Oliveira, Rosimeire Nunes; Ferreira, Pedro Manuel; Calado, Manuela; Belo, Silvana; Afonso, Ana; Garcia, Vera Lúcia; Oliveira, Adriana Silva Santos; et al. "Sesquiterpenes effects on DNA of Schistosoma mansoni after in vivo treatment". Gene Reports 11 (2018): 205-212. http://dx.doi.org/10.1016/j.genrep.2018.04.001.
    10.1016/j.genrep.2018.04.001
  3. Afonso, Ana. "Menthol and Menthone Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Schistosoma mansoni Infected Mice.". Feitosa KA, Zaia MG, Rodrigues V, Castro CA, Correia RO, Pinto FG, Rossi KNZP, Avó LRS, Afonso A and Anibal FF (2018) Menthol and Menthone Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Schistosoma mansoni Infected Mice. Front. Pharmacol. 8:1000. doi: 10.3389/fphar.2017.01000 (2018): https://www.ncbi.nlm.nih.gov/pubmed/29403382.
  4. Afonso, A. "Comparative Proteomics of Praziquantel Susceptible and Praziquantel Resistant Schistosoma mansoni". BIORXIV (2018): https://www.biorxiv.org/content/10.1101/314724v1.full.
    Published
  5. Urbaczek, Ana Carolina; Leão, Paulo Augusto Gomes Carneiro; Souza, Fayene Zeferino Ribeiro de; Afonso, Ana; Vieira Alberice, Juliana; Cappelini, Luciana Teresa Dias; Carlos, Iracilda Zeppone; Carrilho, Emanuel. "Endothelial Cell Culture Under Perfusion On A Polyester-Toner Microfluidic Device". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/s41598-017-11043-0.
    Open access • Published • 10.1038/s41598-017-11043-0
  6. Afonso, Ana. "Involvement of leukotrienes in the immune modulation of oral tolerance". OLIVEIRA S, NONIZO A, FRANTZ F, FACCIOLI L, MATOS A, AFONSO A, ANIBAL FF. (2017) Involvement of leukotrienes in the immune modulation of oral tolerance Frontiers in Microbiology, section Microbial Immunology, 8:242. (2017): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318402/.
  7. Afonso, Ana. "Molecular characterization of Dirofilaria spp. circulating in Portugal". FERREIRA C, AFONSO A, CALADO M, MAURICIO I, ALHO AM, MEIRELES J, MADEIRA DE CARVALHO L, BELO S. (2017) Molecular characterization of Dirofilaria spp. circulating in Portugal, Parasites & Vectors. 10:250 (2017): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438543/.
  8. Afonso, Ana. "Curcumin Generates Oxidative Stress and Induces Apoptosis in Adult Schistosoma mansoni Worms.". DE PAULA AD, BRUNETTO MMM, REZENDE MORAIS E, GRACIANO DE PAULA R, FERREIRA PM, AFONSO A, et al. (2016) Curcumin Generates Oxidative Stress and Induces Apoptosis in Adult Schistosoma mansoni Worms. PLoS ONE 11(11): e0167135. doi:10.1371/journal. pone.0167135 (2016): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119855/.
  9. Afonso, Ana. "Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection.". ZAIA MG, CAGNAZZO TD, FEITOSA KA, SOARES EG, FACCIOLI LH, ALLEGRETT SM, AFONSO A, ANIBAL F DE F.Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection. Front Pharmacol. 2016 Jun 17;7:170. doi: 10.3389/fphar.2016.00170. eCollection 2016. (2016): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911957/.
  10. Afonso, Ana. "Morphological Characteristics of Schistosoma mansoni PZQ-Resistant and -Susceptible Strains Are Different in Presence of Praziquantel.". PINTO-ALMEIDA A, MENDES T, DE OLIVEIRA RN, CORRÊA SAP, ALLEGRETTI SM, BELO S, TOMÁS A, ANIBAL FF, CARRILHO E and AFONSO A Morphological Characteristics of Schistosoma mansoni PZQ-Resistant and -Susceptible Strains Are Different in Presence of Praziquantel. Front. Microbiol. 7:594, 2016. (2016): https://www.frontiersin.org/articles/10.3389/fmicb.2016.00594/full.
  11. Pinto-Almeida, António; Mendes, Tiago; Armada, Ana; Belo, Silvana; Carrilho, Emanuel; Viveiros, Miguel; Afonso, Ana. "The Role of Efflux Pumps in Schistosoma mansoni Praziquantel Resistant Phenotype". PLOS ONE 10 10 (2015): e0140147. http://dx.doi.org/10.1371/journal.pone.0140147.
    10.1371/journal.pone.0140147
  12. Urbaczek, Ana Carolina; Ximenes, Valdecir Farias; Afonso, Ana; Generoso, Wesley Cardoso; Nogueira, Camila Tita; Tansini, Aline; Cappelini, Luciana Teresa Dias; et al. "Recombinant hepatitis C virus-envelope protein 2 interactions with low-density lipoprotein/CD81 receptors". Memórias do Instituto Oswaldo Cruz 110 4 (2015): 534-542. http://dx.doi.org/10.1590/0074-02760140441.
    Open access • 10.1590/0074-02760140441
  13. Urbaczek, Ana Carolina; Ximenes, Valdecir Farias; Afonso, Ana; Generoso, Wesley Cardoso; Nogueira, Camila Tita; Tansini, Aline; Cappelini, Luciana Teresa Dias; et al. "Recombinant hepatitis C virus-envelope protein 2 interactions with low-density lipoprotein/CD81 receptors". Memórias do Instituto Oswaldo Cruz 110 4 (2015): 534-542. http://dx.doi.org/10.1590/0074-02760140441.
    10.1590/0074-02760140441
  14. Afonso, Ana. "Toxocara canis and the allergic process". ZAIA MG, OLIVEIRA SR, CASTRO CA, SOARES EG, AFONSO A, Monnazzi LG, PEITL FILHO O, FACCIOLI LH, ANIBAL F DE F Toxocara canis and the allergic process Mem Inst Oswaldo Cruz. Sep;110(6):726-31, 2015. (2015): https://www.ncbi.nlm.nih.gov/pubmed/26517650.
  15. Afonso, Ana. "The Role of Efflux Pumps in Schistosoma mansoni Praziquantel Resistant Phenotype.". PINTO-ALMEIDA, ANTÓNIO; MENDES, TIAGO; ARMADA, ANA; BELO, SILVANA; CARRILHO, EMANUEL; VIVEIROS, MIGUEL; AFONSO, ANA. The Role of Efflux Pumps in Schistosoma mansoni Praziquantel Resistant Phenotype. Plos One, v. 10, p. e0140147, 2015. (2015): http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140147.
  16. Urbaczek, Ana Carolina; Ribeiro, Lívia Carolina de Abreu; Ximenes, Valdecir Farias; Afonso, Ana; Nogueira, Camila Tita; Generoso, Wesley Cardoso; Alberice, Juliana Vieira; et al. "Inflammatory response of endothelial cells to hepatitis C virus recombinant envelope glycoprotein 2 protein exposure". Memórias do Instituto Oswaldo Cruz 109 6 (2014): 748-756. http://dx.doi.org/10.1590/0074-0276140090.
    Open access • Published • 10.1590/0074-0276140090
  17. Urbaczek, Ana Carolina; Ribeiro, Lívia Carolina de Abreu; Ximenes, Valdecir Farias; Afonso, Ana; Nogueira, Camila Tita; Generoso, Wesley Cardoso; Alberice, Juliana Vieira; et al. "Inflammatory response of endothelial cells to hepatitis C virus recombinant envelope glycoprotein 2 protein exposure". Memórias do Instituto Oswaldo Cruz 109 6 (2014): 748-756. http://dx.doi.org/10.1590/0074-0276140090.
    10.1590/0074-0276140090
  18. Dejani, Naiara N.; Souza, Laís C.; Oliveira, Sandra R.P.; Neris, Débora M.; Rodolpho, Joice M.A.; Correia, Ricardo O.; Rodrigues, Vanderlei; et al. "Immunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.". Immunobiology 219 8 (2014): 627-632. http://dx.doi.org/10.1016/j.imbio.2014.03.015.
    10.1016/j.imbio.2014.03.015
  19. Cossa-Moiane, I.L.; Mendes, T.; Ferreira, T.M.; Mauricio, I.; Calado, M.; Afonso, A.; Belo, S.. "The role of the immunological background of mice in the genetic variability of Schistosoma mansoni as detected by random amplification of polymorphic DNA". Journal of Helminthology 89 6 (2014): 714-719. http://dx.doi.org/10.1017/s0022149x14000492.
    10.1017/s0022149x14000492
  20. Afonso, Ana. "Immunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.". DEJANI, NAIARA N.; SOUZA, LAÍS C.; OLIVEIRA, SANDRA R.P.; NERIS, DÉBORA M.; RODOLPHO, JOICE M.A.; CORREIA, RICARDO O.; RODRIGUES, VANDERLEI; SACRAMENTO, LUIS V.S.; FACCIOLI, LÚCIA H.;AFONSO, ANA; ANIBAL, FERNANDA F.. Immunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.. Immunobiology (Jena. 1979), v. 21 (2014):
    http://dx.doi.org/10.1016/j.imbio.2014.03.015
  21. Afonso, Ana. "The role of the immunological background of mice in the genetic variability of Schistosoma mansoni as detected by random amplification of polymorphic DNA". COSSA-MOIANE, I.L.; MENDES, T.; FERREIRA, T.M.; MAURICIO, I.; CALADO, M.; AFONSO, A.; BELO, S. The role of the immunological background of mice in the genetic variability of Schistosoma mansoni as detected by random amplification of polymorphic DNA. Journal of Helminthology, v. 1, p. 1-6, 2014. (2014):
    http://dx.doi.org/10.1017/S0022149X14000492
  22. Afonso, A. "HARPAGOPHYTUM PROCUMBENS MODULATES EOSINOPHILIC RESPONSE DURING INFECTION BYTOXOCARA CANIS". International Journal of Recent Scientific Research 5 11 (2014): 2008-2013. file:///C:/Users/AnaAfonso/Downloads/Artigoparasitologia%20(1).pdf.
    Open access • Published
  23. Afonso, A. "Análise genética de estripes de Schistosoma mansoni sensíveis e resistentes a Praziquantel por RAPD-PCR.". Anais do Instituto de Higiene e Medicina Tropical, Lisboa, Portugal (2013): 41-45.
    Open access • Submitted
  24. Afonso, Ana; Neto, Zoraima; Castro, Helena; Lopes, Dinora; Alves, Ana C; Tomás, Ana M; Rosário, Virgílio D. "Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene". Malaria Journal 9 1 (2010): http://dx.doi.org/10.1186/1475-2875-9-135.
    10.1186/1475-2875-9-135
  25. Afonso, Ana. "Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene.". AFONSO, A. NETO Z, CASTRO H, LOPES D, ALVES AC, TOMÁS AM, ROSÁRIO VD. Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene. Malar J. 2010 May 21;9:135 (2010):
  26. Hunt, Paul; Afonso, Ana; Creasey, Alison; Culleton, Richard; Sidhu, Amar Bir Singh; Logan, John; Valderramos, Stephanie G.; et al. "Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites". Molecular Microbiology 65 1 (2007): 27-40. http://dx.doi.org/10.1111/j.1365-2958.2007.05753.x.
    10.1111/j.1365-2958.2007.05753.x
  27. Cheesman, Sandra; Creasey, Alison; Degnan, Kathryn; Kooij, Taco; Afonso, Ana; Cravo, Pedro; Carter, Richard; Hunt, Paul. "Validation of Pyrosequencing™ for accurate and high throughput estimation of allele frequencies in malaria parasites". Molecular and Biochemical Parasitology 152 2 (2007): 213-219. http://dx.doi.org/10.1016/j.molbiopara.2006.12.008.
    10.1016/j.molbiopara.2006.12.008
  28. Afonso, Ana. "Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites". HUNT, PAUL; AFONSO, ANA; CREASEY, ALISON; CULLETON, RICHARD; SIDHU, AMAR BIR SINGH; LOGAN, JOHN; VALDERRAMOS, STEPHANIE G.; MCNAE, IAIN; CHEESMAN, SANDRA; ROSARIO, VIRGILIO DO; CARTER, RICHARD; FIDOCK, DAVID A.; CRAVO, PEDRO. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Molecular Microbiology (Online), v. 65, p. 27-40, 2007. (2007):
    10.1111/j.1365-2958.2007.05753.x
  29. Afonso, Ana. "Validation of Pyrosequencing- for accurate and high throughput estimation of allele frequencies in malaria parasites". CHEESMAN, SANDRA; CREASEY, ALISON; DEGNAN, KATHRYN; KOOIJ, TACO; AFONSO, ANA; CRAVO, PEDRO; CARTER, RICHARD; HUNT, PAUL. Validation of Pyrosequencing-for accurate and high throughput estimation of allele frequencies in malaria parasites. Molecular and Biochemical Parasitology (Print), v. 152, p. 213-219, 2007. (2007):
    10.1016/j.molbiopara.2006.12.008
  30. Cardoso, Carla S.; Araújo, Hélder C.; Cruz, Eugénia; Afonso, Ana; Mascarenhas, Cláudia; Almeida, Susana; Moutinho, José; Lopes, Carlos; Medeiros, Rui. "Haemochromatosis gene (HFE) mutations in viral-associated neoplasia: Linkage to cervical cancer". Biochemical and Biophysical Research Communications 341 1 (2006): 232-238. http://dx.doi.org/10.1016/j.bbrc.2005.12.174.
    10.1016/j.bbrc.2005.12.174
  31. Afonso, A.; Hunt, P.; Cheesman, S.; Alves, A. C.; Cunha, C. V.; do Rosa´rio, V.; Cravo, P.. "Malaria Parasites Can Develop Stable Resistance to Artemisinin but Lack Mutations in Candidate Genes atp6 (Encoding the Sarcoplasmic and Endoplasmic Reticulum Ca2+ ATPase), tctp, mdr1, and cg10". Antimicrobial Agents and Chemotherapy 50 2 (2006): 480-489. http://dx.doi.org/10.1128/aac.50.2.480-489.2006.
    10.1128/aac.50.2.480-489.2006
  32. Cravo, P.; Culleton, R.; Afonso, A.; Ferreira, I.; do Rosario, V.. "Mechanisms of Drug Resistance in Malaria: Current and New Challenges". Anti-Infective Agents in Medicinal Chemistry 5 1 (2006): 63-73. http://dx.doi.org/10.2174/187152106774755590.
    10.2174/187152106774755590
  33. Afonso, Ana. "Mechanisms of Drug Resistance in Malaria: Current and New Challanges". AFONSO, ANA; CRAVO, P.; ROSARIO, V.; CULLETON, R.; FERREIRA, I. D. Mechanisms of Drug Resistance in Malaria: Current and New Challenges. Anti-Infective Agents in Medical Chemistry, v. 5, p. 63, 2006. (2006):
  34. Afonso, Ana. "Haemochromatosis gene (HFE) mutations in viral-associated neoplasia: Linkage to cervical cancer". CARDOSO, CARLA S.; ARAÚJO, HÉLDER C.; CRUZ, EUGÉNIA ; AFONSO, ANA ; MASCARENHAS, CLÁUDIA ; ALMEIDA, SUSANA ; MOUTINHO, JOSÉ ; LOPES, CARLOS ; MEDEIROS, RUI . Haemochromatosis gene (HFE) mutations in viral-associated neoplasia: Linkage to cervical cancer. Biochemical and Biophysical Research Communications (Print), v. 341, p. 232-238, 2006. (2006):
    10.1016/j.bbrc.2005.12.174
  35. Afonso, Ana. "Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.". AFONSO, ANA; HUNT, P.; ROSARIO, V; CRAVO, P.; CHEESEMAN, S; CUNHA, C. V.; ALVES, A. C. Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.. Antimicrobial Agents and Chemotherapy (Print), v. 50, p. 408, 2006. (2006):
  36. Suspiro, Alexandra; Pereira, A.Dias; Afonso, Ana; Albuquerque, Cristina; Chaves, Paula; Soares, Jorge; Leitao, C.Nobre. "Losses of heterozygosity on chromosomes 9p and 17p are frequent events in Barrett's metaplasia not associated with dysplasia or adenocarcinoma". The American Journal of Gastroenterology 98 4 (2003): 728-734. http://dx.doi.org/10.1111/j.1572-0241.2003.07411.x.
    10.1111/j.1572-0241.2003.07411.x
  37. Afonso, Ana. "Losses of heterozygosity on chromosomes 9p and 17p are frequent events in Barrett's metaplasia not associated with dysplasia or adenocarcinoma". SUSPIRO, ALEXANDRA; PEREIRA, A.DIAS; AFONSO, ANA; ALBUQUERQUE, CRISTINA ; CHAVES, PAULA ; SOARES, JORGE ; LEITAO, C.NOBRE . Losses of heterozygosity on chromosomes 9p and 17p are frequent events in Barrett's metaplasia not associated with dysplasia or adenocarcinoma. The American Journal of Gastroenterology, v. 98, p. 728-734, 2003 (2003):
    10.1111/j.1572-0241.2003.07411.x
  38. Cravo, M. "Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing". Gut 50 3 (2002): 405-412. http://dx.doi.org/10.1136/gut.50.3.405.
    10.1136/gut.50.3.405
  39. Afonso, Ana. "Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing.". AFONSO, ANA; CRAVO, M.; LAGE, P.; ALBUQUERQUE, C.; MAIA, L.; LACERDA, C.; FIDALGO, P.; CHAVES, P.; CRUZ, C.; NOBRE-LEITAO, C. Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing.. GUT LIVER, v. 50, p. 405, 2002. (2002):
Magazine article
  1. Afonso, A; Belo, Silvana; Calado, Manuela. "Principais helmintoses negligenciadas ontem, hoje e amanhã no IHMT", Anais do Instituto de Higiene e Medicina Tropical, 2013
  2. Afonso, A; Ferreira, Pedro Manuel; Belo, Silvana; Calado, Manuela. "Atenção à schistosomose. Lisboa: Visão, 2012 (Artigo de Opinião Sociedade).", Visão, 2012
  3. Mendes, Tiago Manuel Fernandes; Calado, Manuela; Clemente, Isabel; Belo, Silvana; Afonso, A. "Análise genética de estripes de Schistosoma mansoni sensíveis e resistentes a Praziquantel por RAPD-PCR.", Anais do Instituto de Higiene e Medicina Tropical, 2012
  4. Afonso, A. "A História da Bioquímica.", Biosofia , 2007
Newspaper article
  1. Afonso, A; Belo, Silvana; Ferreira, Pedro Manuel; Calado, Manuela. "A importância do diagnóstico molecular em schistosomose.", Luanda: Jornal da Saúde de Angola, 2012 (Artigo de Opinião). , 2012
Thesis / Dissertation
  1. Afonso, A. "Elaboração de um dossier de valor terapêutico: Benralizumab". Master, Centro de Estudos Avançados da Industria Farmacêutica, 2018.
  2. Afonso, A. "Artemisinin drug resistance mechanisms". PhD, Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, 2007.
  3. Afonso, A. "Diagnóstico genético do síndroma de Lynch, deteção de mutações nos genes de reparação do DNA: hMLH1 e hMSH2". Degree, Fundação da Faculdade de Ciências da Universidade de Lisboa, 1998.
Website
  1. Afonso, A. 1111 COISAS QUE QUERO ENSINAR AO MEU FILHO. 2012. https://1111coisasparaomeufilho.blogspot.com/.

Artistic / Performance

Program / Show
  1. Afonso, A. 2013. Schistosomose: Problema de Saúde Publica. Lisboa: RTP-AFRICA, 2013 (Programa de Televisão para Ensino Médico à Distância).. RTP-AFRICA.
Short fiction
  1. Afonso, A. 2007. "O menino com a bola amarela.". In www.univadis.pt. Lisboa, Portugal: UNIVADIS.

Intellectual property

Provisional application for patent
  1. 2020. "Microchip para cultura celular e mimetizações para estudos farmacológicos e toxicológicos de substâncias químicas e nano partículas e outras espécies celularmente ativas – desenho, fabricação e uso do mesmo.".
    Protected
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2012 - 2012 Praziquantel-resistance in Schistosoma mansoni: role of efflux pumps, phenotypic characteristics and proteomics analysis
Supervisor
 Biologia Básica e Aplicada (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
1997 - Current Organizadora das Jornadas de Genética Humana pela Associação Juvenil de Ciência, de 7-9 de Novembro de 1997 – ITQB – Oeiras. (1997)
Congress (Co-organisor)
 Associação Juvenil de Ciencia, Portugal

Association member

Society Organization name Role
1998 - Current Sociedade Portuguesa de Bioquímica Membro

Committee member

Activity description
Role 		Institution / Organization
2014 - Current Presidente da Comissão Cientifica do VII Congresso da Sociedade Paulista de Parasitologia a ser realizado de 14-16 de Novembro de 2014, São Carlos, São Paulo, Brasil. 2014.
President / Vice-president
 Sociedade Paulista de Parasitologia , Brazil
2012 - Current Membro da Comissão Organizadora do XVI Congresso de Parasitologia, Faculdade de Medicina Veterinária de Lisboa, 29-30 novembro 2012
Member
 Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2010 - Current Membro da Comissão Cientifica da Jornada Científica do IHMT, 13 de Outubro de 2010, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa. 2010.
Member
2009 - Current Membro da Comissão Organizadora do X Congresso Ibérico de Parasitologia que decorreu no Instituto de Higiene e Medicina Tropical, Lisboa de 15 a 18 de Setembro de 2009.
Member
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2014 - Current VII Congresso da Sociedade Paulista de Parasitologia a ser realizado de 14-16 de Novembro de 2014, São Carlos, São Paulo, Brasil. 2014.
Evaluator
 Universidade Federal de São Carlos Centro de Ciências Exatas e de Tecnologia, Brazil Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2012 AFONSO, A ; BELO, S.; CALADO, M.; FERREIRA, P.. A importância do diagnóstico molecular em schistosomose. Luanda: Jornal da Saúde de Angola, 2012 (Artigo de Opinião). Jornal da Saúde de Angola, 2012 (Artigo de Opinião).
2012 AFONSO, A ; BELO, S.; CALADO, M.; FERREIRA, P. . Atenção à schistosomose. Lisboa: Visão, 2012 (Artigo de Opinião Sociedade). Visão

Interview (tv / radio show)

Program Topic
2013 - Current AFONSO, A . Schistosomose: Problema de Saúde Publica. Lisboa: RTP-AFRICA, 2013 (Programa de Televisão para Ensino Médico à Distância). Schistosomose: Problema de Saúde Publica
2013 - Current AFONSO, A . Doenças Infeciosas Re-emergentes com o tema Artemisinina e demais antimaláricos: ontem, hoje e amanhã. 2013. (Programa de rádio ou TV/Mesa redonda). Doenças Infeciosas Re-emergentes com o tema Artemisinina e demais antimaláricos: ontem, hoje e amanhã.

Journal scientific committee

Journal title (ISSN) Publisher
2016 - Current Journal of the Brazilian Chemical Society (0103-5053) Sociedade Brasileira de Quimica (SBQ)
2016 - Current Brazilian Journal of Biology (1519-6984) SciELO
2016 - Current Frontiers in Public Health (2296-2565) Frontiers Media SA
2015 - Current Frontiers in Pharmacology (1663-9812) Frontiers Media SA
2015 - Current South Asian Journal of Research in Microbiology (2582-1989) Sciencedomain International
2014 - Current African Journal of Biochemistry Research (1996-0778) Academic Journals
2013 - Current Frontiers in Microbiology (1664-302X) Frontiers Media SA
2011 - Current Frontiers in Medicine (2296-858X) Frontiers Media SA
2009 - Current PLoS ONE (1932-6203) Public Library of Science
2008 - Current Asian Food Science Journal (2581-7752) Sciencedomain International
2007 - Current International Journal of TROPICAL DISEASE & Health (2278-1005) Sciencedomain International
2007 - Current Frontiers in Immunology (1664-3224) Frontiers Media SA
Distinctions

Award

2015 Melhor apresentação oral
Sociedade Paulista de Parasitologia , Brazil
2011 Melhor apresentação oral,
Congress on Tropical Medicine and International Health. , Spain
2000 Congresso Nacional de Gastrenterologia e Endoscopia Digestiva.
Sociedade Portuguesa de Gastrenterologia, Portugal
2000 Melhor Poster
Sociedade Portuguesa de Gastrenterologia, Portugal