Andreia Margarida Gonçalves das Neves Carvalho (A813-6CDE-641A)

Curriculum Vitae

Andreia Margarida Gonçalves das Neves Carvalho

Andreia Neves Carvalho main research focus is on the characterization of the molecular mechanisms underlying mitochondrial dysfunction, oxidative and endoplasmic reticulum stress and associated neuro-axonal damage leading to neurodegeneration. In this context she is interested in the research of new molecular mechanisms involved in the regulation of mitochondrial function, at the level of mitochondrial biogenesis and mitochondrial dynamics, namely through post-translational modifications of key proteins involved in these processes, in order to pursue new potential therapeutic targets and strategies for the treatment of neurodegenerative diseases. Andreia Neves Carvalho got her PhD in Pharmacy - Biochemistry in 2012 by the University of Lisbon. She then worked as a post-doctoral fellow at the Department of Molecular Cell Biology and Immunology of the VU University Medical Centre, Amsterdam, The Netherlands. During this period she was the recipient of a DuPré Grant from Multiple Sclerosis International Federation (MSIF) and an ECTRIMS Postdoctoral Research Fellowship from European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). She moved back to Portugal working as a Researcher at iMed.ULisboa, Faculty of Pharmacy, University of Lisbon where she is currently an Invited Assistant Professor.

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Identification

Personal identification

Full name: Andreia Margarida Gonçalves das Neves Carvalho

Citation names

Carvalho, Andreia N
Neves Carvalho, A

Author identifiers

Ciência ID: A813-6CDE-641A
ORCID iD: 0000-0001-9605-5054
Researcher Id: ISU-9035-2023
Scopus Author Id: 55194180800

Email addresses

amcarvalho@ff.ulisboa.pt (Professional)

Addresses

iMED.ULisboa - Research Institute for Medicines, Faculty of Pharmacy, University of Lisbon. Av. Prof. Gama Pinto, 1649-003 , Lisboa, Lisboa, Portugal (Professional)

Websites

https://imed.ulisboa.pt/cv/andreia-neves-carvalho/ (Scholar)

Knowledge fields

Natural sciences - Biological Sciences - Biochemistry
Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Dutch	Elementary (A2)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)
German	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2023 Concluded	CONGENTO Course on Modules 9, 10 and 11 according to the EC Common Education and Training Framework ("Upgrade Course" on Laboratory Animal Sciences) (Pós-Graduação) Fundação Champalimaud, Portugal Instituto Gulbenkian de Ciência, Portugal
2022 Concluded	Post-graduate course "Characterisation of post-translational modifications in cellular signalling" (Pós-Graduação) Syddansk Universitet, Denmark
2020 Concluded	Post-graduate Course on Laboratory Animal Sciences (FELASA B) (Pós-Graduação) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012/10 Concluded	Pharmacy (Doutoramento) Major in Biochemistry Universidade de Lisboa Faculdade de Farmácia, Portugal "Role of Glutathione S-Transferase pi in Neuronal Protection under Oxidative Stress and Proteasome Inhibition - Relevance to Parkinson's Disease" (THESIS/DISSERTATION)	Distinção e Louvor
2009 Concluded	Post-graduate course BioEM09 – A new age in electron microscopy: an international meeting on Biomedical Electron Microscopy Applications. (Pós-Graduação) Universidade de Coimbra Faculdade de Medicina, Portugal
2007 Concluded	Post-graduate course Biology of Cell Death I – Mechanisms of Apoptosis, 4th ed. (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/07 Concluded	Biochemistry (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal "Study of the variations of expression of the gene Gstp and of apoptosis genes, induced by MPTP, in mice brain" (THESIS/DISSERTATION)	16/20

Affiliation

Science

	Category Host institution	Employer
2019/03/01 - 2025/02/28	Researcher (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2014/11/01 - 2019/02/28	Postdoc (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2025/03/01 - Current	Invited Assistant Professor (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

	Category Host institution	Employer
2013/09/01 - 2014/10/31	Post-doctoral fellow with an ECTRIMS Postdoctoral Research Fellowship from European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)	VU Medisch Centrum, Netherlands
	VU Medisch Centrum, Netherlands
2013/01/01 - 2013/04/30	Post-doctoral fellow	VU Medisch Centrum, Netherlands

2012/11/01 - 2012/12/31	Post-doctoral fellow, with a DuPré Grant from Multiple Sclerosis International Federation (MSIF)	VU Medisch Centrum, Netherlands

2008/05/01 - 2012/10/04	PhD student - PhD fellowship from FCT/ Bolseira de Doutoramento	Universidade de Lisboa Faculdade de Farmácia, Portugal

2007/05/01 - 2008/04/30	Scientific Investigation Fellow / Bolseira de Investigação	Universidade de Lisboa Faculdade de Farmácia, Portugal

2006/09/01 - 2007/04/30	Scientific Investigation Fellow / Bolseira de Investigação	Universidade de Coimbra Faculdade de Medicina, Portugal

Projects

Grant

	Designation	Funders
2022/01 - 2023/12	REMIND - REdox-signaling modulation of MItochoNdrial Dysfunction through post-translational modifications EXPL/BIA-BQM/0793/2021 Principal investigator	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2021	PGC-1alpha Isoforms as novel Therapeutic targets in ParkinsON's Disease PTDC/MED-FSL/30104/2017 Researcher Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2021	TITANIC - CYP46A1 as a new TherapeutIcTArget in NIemann-Pick type C disease PTDC/MED-NEU/29455/2017 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2013/06 - 2015/11	S-Glutathionylation in Parkinson´s Disease. Provided by PTCRIS: 124942 Post-doc Fellow	Fundação para a Ciência e a Tecnologia Concluded
2013/06 - 2015/11	Unraveling the neuroprotective role of TUDCA in Parkinson´s disease: targeting oxidative stress and mitophagy Provided by PTCRIS: 124452 Post-doc Fellow	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2014	Mitochondrial dynamics in multiple sclerosis n.a. Post-doc Fellow VU Medisch Centrum, Netherlands	European Committee for Treatment and Research in Multiple Sclerosis Concluded
2013 - 2013	Protective effects of endogenous antioxidants in Multiple Sclerosis 061112 Researcher VU Medisch Centrum, Netherlands	Hersenstichting Concluded
2005/07 - 2008/04	Evaluation of the protective role of Glutathione S-Transferase pi against MPTP neurotoxicity Provided by PTCRIS: 58171 PhD Student Fellow	Fundação para a Ciência e a Tecnologia
2005/09 - 2007/12	What HIF? Degradation is better than growth in preventing angiogenesis in diabetic retinopathy Provided by PTCRIS: 57772 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference abstract	Kovalchuk, Daria Alexandrovna; Anjo, Sandra I.; Nunes, Maria João; Branco, Vasco; Santos, Fabiana; Caria, Inês; Castro-Caldas, Margarida; et al. "Cysteine redox post-translational modifications: the missing link between redox-signalling and mitochondrial dynamics and function in Parkinson's disease?". 2023. 10.1016/j.freeradbiomed.2023.03.142 Carvalho, Andreia; Ranito, Catarina; Tavares, Carolina; Castro-Caldas, Margarida; Rodrigues, Elsa; Ruas, Jorge; Van Horssen, Jack; Gama, Maria. "Activation of the Unfolded Protein Response in Parkinson's disease". 2019. 10.3389/conf.fncel.2019.01.00051 Nunes MJ, Caria I,; Carvalho, Andreia N; Costa D, Castro-Caldas M, Gama MJ, Rodrigues E and Ruas JL. "Deciphering the role of cholesterol homeostasis in Parkinson's Disease". Paper presented in The 7th Mediterranean Neuroscience Conference, Marrakech, 2019. Published Dionísio P, Rosa AI, Duarte-Silva S, Nunes MJ,; Carvalho, Andreia N; Rodrigues E, Maciel P, Videira P, Rodrigues CMP, Gama MJ, Castro-Caldas, M. "Neuroprotection in Parkinson's disease by Tauroursodeoxycholic acid: from rescuing cellular degeneration to improving motor symptoms". Paper presented in The 14th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD), Lisbon, 2019. Published Nunes, Maria; Caria, Ines; Carvalho, Andreia; Costa, Daniela; Castro-Caldas, Margarida; Gama, Maria; Rodrigues, Elsa; Ruas, Jorge. "Unanswered role of cholesterol homeostasis in Parkinson's disease". 2019. 10.3389/conf.fncel.2019.01.00024 Rodrigues, Elsa; Costa, Daniela; Moutinho, Miguel; Nunes, Maria; Silva, Margarida; Mendes De Almeida, Rita; Carvalho, Andreia; et al. "CYP46A1 expression modulates mitochondrial function and integrity in Niemann-Pick type C disease". 2019. 10.3389/conf.fncel.2019.01.00030 Guedes RA, Sousa CL, Falcao AO, Gallerani E, Gavioli R,; Carvalho, Andreia N; Gama MJ, Salvador JA, Guedes RC. "Finding new molecules to inhibit the 20S proteasome in anticancer therapy: computer-aided drug design and biological evaluation.". Paper presented in 5th EFMC Young Medicinal Chemist Symposium, at the XXV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2018), Ljubljana, 2018. Carvalho, Andreia Neves; Tavares, Carolina Pereira; Rodrigues, Elsa; Castro-Caldas, Margarida; van Horssen, Jack; Gama, Maria João. "S-glutathionylation and endoplasmic reticulum stress in Parkinson's disease". 2018. 10.1016/j.freeradbiomed.2018.04.527 Guedes RA, Sousa CL, Falcao AO, Gallerani E, Gavioli R,; Carvalho, Andreia N; Gama MJ, Salvador JA, Guedes RC. "New molecules to inhibit the 20S proteasome in anticancer therapy: computer-aided drug design methodologies and biological evaluation.". Paper presented in XXV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2018), Ljubljana, 2018. Mendes MO, Rosa AI, Nunes MJ,; Carvalho, Andreia N; Duarte-Silva S, Silva-Fernandes A, Rodrigues E, Maciel P, Rodrigues CMP, Gama MJ, Castro-Caldas M. "Neuroprotective effects of Tauroursodeoxycholic acid in MPTP model of Parkinson's disease: A study in the mouse cortex.". Paper presented in MitoPorto – Advances in Mitochondrial Research, International Symposium, Porto, 2017. Carvalho, A. N.; Azevedo, C. S.; Santos, M. A.; Rodrigues, E.; Castro-Caldas, M.; Gama, M. J.. "Unfolded Protein Response in Parkinson's disease: a new neuroprotective role for Glutathione S-Transferase pi?". Paper presented in 40th Congress of the Federation of European Biochemical Societies (FEBS) – The Biochemical Basis of Life, Berlin, 2015. Published Carvalho, A. N.; Nijland, P. G.; Muntslag, T.; Hof, B. van Het; van der Pol, S.; Witte, M. E.; van Horssen, J.. "Mitochondrial dynamics dysfunction in multiple sclerosis". Paper presented in 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Barcelona, 2015. Published Carvalho, Andreia N; Azevedo C, Rodrigues E, Castro-Caldas M and Gama MJ. "Modulation of the Unfolded Protein Response and Antioxidant Response by S-glutathionylation (Young Scientist Program)". Paper presented in Young Scientist Program of the 23rd Congress of the International Union of Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), São Paulo, 2015. Carvalho, Andreia N; Azevedo C, Rodrigues E, Castro-Caldas M and Gama MJ. "Modulation of the Unfolded Protein Response and Antioxidant Response by S-glutathionylation". Paper presented in 23rd Congress of the International Union of Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), Foz do Iguaçu, 2015. Nunes, MJ; Carvalho, Andreia N; Silva-Azevedo C, Santos MA, Castro-Caldas M, Rodrigues E and Gama MJ. "MPTP-Induced oxidative stress and Nrf2-dependent regulation of GSTP gene promotor". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences (SPN 2015), Póvoa de Varzim, 2015. Santos MA,; Carvalho, Andreia N; Silva-Azevedo C, Castro-Caldas M., Rodrigues E., Gama M.J. "Characterization of the effects of MPTP insult on ER stress response in C57/BL6 wild type and Gstp null mice brain". Paper presented in 29ª Reunião do Grupo de Estudo de Envelhecimento Cerebral e Demências (GEECD), Aveiro, 2015. Neves Carvalho, A.; Marques, C.; Castro-Caldas, M.; Rodrigues, E.; Henderson, C. J.; Wolf, C. R.; Pereira, P.; Gama, M. J.. "In vivo Keap1 S-glutathionylation". Paper presented in FEBS-EMBO 2014 Conference, Paris, 2014. Published Carvalho, Andreia N; Witte ME and van Horssen J. "Mitochondrial dynamics dysfunction in Multiple Sclerosis". Paper presented in XVIII Congress of the Portuguese Biochemical Society, Coimbra, 2014. Carvalho, Andreia N; Marques C, Azevedo CS, Castro-Caldas M, Rodrigues E, Nunes MJ, Henderson CJ, Wolf CR, Pereira P and Gama MJ. "Modulation of Endoplasmic Reticulum Stress by S glutathionylation". Paper presented in XVIII Congress of the Portuguese Biochemical Society, Coimbra, 2014. Carvalho, Andreia N. "Endogenous antioxidants: potential therapeutic targets in Multiple Sclerosis". Paper presented in 6th MSIF Alumni Event at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Copenhagen, 2013. Carvalho, Andreia N; Marques C, Rodrigues E, Pereira P and Gama MJ. "Effect of Proteasome Inhibition on GSTpi expression in C57BL/6 mice nigrostriatal pathway in response to MPTP-induced oxidative stress". Paper presented in Translational aspects of proteolysis in neurodegenerative diseases – satellite of the FENS Forum 2010, Maastricht, 2010. Carvalho, Andreia N; Marques C, Rodrigues E, Pereira P and Gama MJ. "Proteasome Inhibition and GSTpi expression in C57BL/6 mice nigrostriatal pathway in response to MPTP-induced oxidative stress.". Paper presented in 7th FENS Forum of European Neuroscience 2010, Amsterdam, 2010. Carvalho, Andreia N; Marques C, Rodrigues E, Pereira P and Gama MJ. "GSTpi expression in C57BL/6 mice nigrostriatal pathway in response to MPTP-induced oxidative stress and proteasome inhibition". Paper presented in 24ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, Tomar, 2010. Carvalho, Andreia N; Marques C, Rodrigues E, Pereira P and Gama MJ. "Effect of Proteasome Inhibition on MPP+-induced GSTP1 expression in SH-SY5Y cells". Paper presented in 9th International Conference - AD/PD 2009, Prague, 2009. Castro-Caldas M,; Carvalho, Andreia N; Peixeiro I, Rodrigues E, Lechner MC and Gama MJ. "GSTP expression in C57BL/6 mouse brain induced by a single-dose MPTP administration". Paper presented in 21ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência, Luso, 2007. Gama MJ, Castro-Caldas M,; Carvalho, Andreia N; Peixeiro I, Rodrigues E and Lechner MC.. "GSTP1 expression and MPTP-induced dopaminergic neurodegeneration in C57BL/6 mouse brain.". Paper presented in 16th International Symposium on Microsomes and Drug Oxidations, Budapeste, 2006. Castro-Caldas M, Peixeiro I,; Carvalho, Andreia N; Rodrigues E, Lechner MC and Gama MJ. "MPTP-induced neurodegeneration is associated with increases GSTP1 expression in the mouse brain". Paper presented in XV National Congress of Biochemistry, Aveiro, 2006. Gama MJ, Castro-Caldas M,; Carvalho, Andreia N. "Expression of GSTP1 gene in mice brain: effect of in vivo chronic treatment with MPTP". Paper presented in 2nd International Congress on Stress Responses in Biology and Medicine, Tomar, 2005. Castro-Caldas M, Gama MJ,; Carvalho, Andreia N. "Chronological variation of selected apoptotic markers induced by MPTP in mice brain". Paper presented in Neuro-glia Interaction in Aging and Disease – FENS/Blackwell Summer School, Ofir, 2005. Carvalho, Andreia N; Gama MJ, Castro-Caldas M, Rodrigues E and Lechner MC. "Effect of in vivo chronic MPTP treatment on mice global gene expression". Paper presented in 19ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, Tomar, 2005. Castro-Caldas M, Gama MJ,; Carvalho, Andreia N; Rodrigues E and Lechner MC. "Changes in apoptotic pathways in the MPTP mouse model of Parkinson's disease". Paper presented in 19ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, Tomar, 2005.
Conference paper	Carvalho, Neves A.; Marques, C.; Rodrigues, E.; Pereira, P.; Gama, M. J.; Fisher, A; Hanin, I. "Effect of Proteasome Inhibition on MPP(+)-induced GSTP1 Expression in SH-SY5Y Cells". Paper presented in 9th International Conference on Alzheimer and Parkinson Related Disorders AD/PD 2009, Prague, 2009. Published
Conference poster	Ranito C, Rodrigues E,; Carvalho, Andreia N; Gama MJ and Ruas JL. "Small molecule PGC-1alpha activators: a novel approach to anti-neurodegenerative therapeutics". Paper presented in 5th Meeting of the Mind-Brain College of the University of Lisbon and 17th Meeting of Biomedical Engineering, 2019. Ranito C, Rodrigues E,; Carvalho, Andreia N; Gama MJ and Ruas JL. "Small molecule PGC-1alpha activators: a novel approach to anti-neurodegenerative therapeutics". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting and 4th i3DU Meeting, 2019. Guedes RA, Gallerani E, Gavioli R,; Carvalho, Andreia N; Gama MJ, Salvador JA, Guedes RC. "New molecules to inhibit the Human 20S proteasome in Anticancer Therapy: computer-aided drug design methodologies and biological evaluation of the compounds". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting, 2018. Guedes RA, Gallerani E, Gavioli R,; Carvalho, Andreia N; Gama MJ, Salvador JA, Guedes RC. "New molecules to inhibit the 20S proteasome: computer-aided drug design methodologies and biological evaluation.". Paper presented in 3º Encontro do Colégio da Química da Universidade de Lisboa, 2018. Tavares CLA, Rodrigues E, Castro-Caldas M,; Carvalho, Andreia N; Gama MJ. "Modulation of ER stress and autophagy in mice brain and N2a cells under MPTP/MPP+-induced oxidative stress.". Paper presented in 9th iMed.ULisboa Postgraduate Students Meeting, 2017. Mendes MO, Rosa AI, Nunes MJ,; Carvalho, Andreia N; Duarte-Silva S, Silva-Fernandes A, Rodrigues E, Maciel P, Rodrigues CMP, Gama MJ, Castro-Caldas M.. "Extended neuroprotective effect of Tauroursodeoxycholic acid to the mouse cerebral cortex in a MPTP model of Parkinson's disease.". Paper presented in 9th iMed.ULisboa Postgraduate Students Meeting, 2017. Fonseca, I, Moreira S, Nunes MJ, Silva-Azevedo C, de Lemos L,; Carvalho, Andreia N; Rosa A, Rodrigues E, Gama MJ, Rodrigues CMP and Castro-Caldas M. "Unraveling the neuroprotective role of tauroursodeoxycholic acid in Parkinson´s disease". Paper presented in 1º Encontro de Alunos de Doutoramento do Colégio Mente-Cérebro da Universidade de Lisboa, 2015. Moreira S, Fonseca, I, Nunes MJ, Silva-Azevedo C, de Lemos L,; Carvalho, Andreia N; Rosa A, Rodrigues E, Gama MJ, Rodrigues CMP and Castro-Caldas M. "Nrf2 activation by Tauroursodeoxycholic acid in experimental models of Parkinson's disease". Paper presented in 1º Encontro de Alunos de Doutoramento do Colégio Mente-Cérebro da Universidade de Lisboa, 2015. Santos MA,; Carvalho, Andreia N; Nunes MJ, Castro-Caldas M, Rodrigues E, Gama MJ. "Endoplasmic Reticulum Stress Response in C57/BL6 wild type and Gstp null mice Brain under MPTP Oxidative Stress". Paper presented in 7th iMed.ULisboa Postgraduate Students Meeting, 2015. Carvalho, Andreia N; Castro-Caldas M, Marques C, Rodrigues E, Henderson CJ, Wolf CR, Pereira P and Gama MJ. "Neuronal Protection in Parkinson's disease: is there a role for Gst pi?". Paper presented in Molecular Biology in Portugal and EMBL- Faculty of Sciences, University of Lisbon, 2013. Castro-Caldas M,; Carvalho, Andreia N; Rodrigues E, Henderson CJ, Wolf CR, Rodrigues CMP and Gama MJ. "Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease". Paper presented in Molecular Biology in Portugal and EMBL- Faculty of Sciences, University of Lisbon, 2013. Carvalho, Andreia N; Marques C, Girão H, Rodrigues E, Pereira P and Gama MJ. "In vivo studies of Nrf2 expression in the brain: modulation by MPTP induced oxidative stress and proteasome inhibition". Paper presented in 3rd Post Graduate iMED.UL Students Meeting, 2011. Carvalho, Andreia N; Marques C, Girão H, Rodrigues E, Pereira P and Gama MJ. "Nrf2 expression in C57BL/6 mice nigrostriatal pathway in response to MPTP-induced oxidative stress and proteasome inhibition". Paper presented in III Annual Meeting IBILI, 2011. Carvalho, Andreia N; Marques C, Rodrigues E, Pereira P, Gama MJ. "Proteasome inhibition and GSTpi expression in C57BL/6 mice nigrostriatal pathway in response to MPTP-induced oxidative stress". Paper presented in 2nd Post-Graduate iMed.UL Students Meeting, 2010. Castro-Caldas M,; Carvalho, Andreia N; Rodrigues E and Gama MJ. "GSTPi expression in MPTP-induced dopaminergic neurodegeneration of C57BL/6 mouse midbrain and striatum". Paper presented in VI Fórum Internacional de Investigadores Portugueses: “Brain, Life, and Culture”, 2008. Carvalho, Andreia N; Castro-Caldas M, Peixeiro I, Rodrigues E, Lechner MC and Gama MJ. "GSTPi expression in single-dose MPTP-induced dopaminergic cell death of C57BL/6 mouse brain". Paper presented in 1st Internal Meeting of iMED.UL, “Symposium - Pharmaceutical Innovation: Current Trends and Future Hopes”, 2008. Carvalho, Andreia N; Bento C, Fernandes R, Pereira P. "Methylglyoxal decreases the viability and release of VEGF by retinal pigmented epithelium cells". Paper presented in V Congresso de Investigação em Medicina – Pedagogia e Ciência, Coimbra, Portugal, 2006.
Journal article	Kovalchuk, Daria Alexandrovna; Anjo, Sandra I.; Munteanu, Cristian V.A.; Nunes, Maria João; Castro-Caldas, Margarida; Rodrigues, Elsa; Manadas, Bruno; et al. "Redox proteome alterations in Parkinson’s disease: Insights into the role of redox-signalling and mitochondrial dynamics and function". Free Radical Biology and Medicine 233 (2025): S39-S40. https://doi.org/10.1016/j.freeradbiomed.2025.05.143. 10.1016/j.freeradbiomed.2025.05.143 Sandra I. Anjo; Zhicheng He; Zohaib Hussain; Aruba Farooq; Alan McIntyre; Charles A. Laughton; Andreia Neves Carvalho; Mattéa J. Finelli. "Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers". Antioxidants (2024): https://doi.org/10.3390/antiox13060681. 10.3390/antiox13060681 Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Costa, Daniela; Moutinho, Miguel; Mateus, Joana; Mendes de Almeida, Rita; et al. "Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 3 (2024): 166993. http://dx.doi.org/10.1016/j.bbadis.2023.166993. 10.1016/j.bbadis.2023.166993 Nunes, M.J.; Carvalho, A.N.; Sá-Lemos, C.; Colaço, M.; Cervenka, I.; Ciraci, V.; Santos, S.G.; et al. "Sustained PGC-1a2 or PGC-1a3 expression induces astrocyte dysfunction and degeneration". European Journal of Cell Biology 103 1 (2024): 151377. http://dx.doi.org/10.1016/j.ejcb.2023.151377. 10.1016/j.ejcb.2023.151377 Caria, Inês; Nunes, Maria João; Ciraci, Viviana; Carvalho, Andreia Neves; Ranito, Catarina; Santos, Susana G.; Gama, Maria João; et al. "NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 2 (2024): 166980. http://dx.doi.org/10.1016/j.bbadis.2023.166980. 10.1016/j.bbadis.2023.166980 Nunes, Maria João; Carvalho, Andreia Neves; Rosa, Alexandra I.; Videira, Paula A.; Gama, Maria João; Rodrigues, Elsa; Castro-Caldas, Margarida. "Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease". Journal of Molecular Medicine (2024): http://dx.doi.org/10.1007/s00109-023-02415-3. 10.1007/s00109-023-02415-3 Romina A. Guedes; Jorge H. Grilo; Andreia N. Carvalho; Pedro M. P. Fernandes; Ana S. Ressurreição; Vanessa Brito; Adriana O. Santos; et al. "New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies". Pharmaceuticals (2023): https://doi.org/10.3390/ph16081096. 10.3390/ph16081096 Carvalho, Andreia N.; Branco, Vasco; van Horssen, Jack; Saso, Luciano. "Editorial: Redox-signaling in neurodegenerative diseases: biomarkers, targets, and therapies". Frontiers in Cellular Neuroscience 17 (2023): http://dx.doi.org/10.3389/fncel.2023.1198669. 10.3389/fncel.2023.1198669 Leonardo-Sousa, Carlota; Carvalho, Andreia Neves; Guedes, Romina A.; Fernandes, Pedro M. P.; Aniceto, Natália; Salvador, Jorge A. R.; Gama, Maria João; Guedes, Rita C.. "Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance". Molecules 27 7 (2022): 2201. http://dx.doi.org/10.3390/molecules27072201. 10.3390/molecules27072201 Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280. 10.1080/15548627.2020.1797280 Mendes, Mariana Oliveira; Rosa, Alexandra Isabel; Carvalho, Andreia Neves; Nunes, Maria João; Dionísio, Pedro; Rodrigues, Elsa; Costa, Daniela; et al. "Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy". Molecular and Cellular Neuroscience 96 (2019): 1-9. http://dx.doi.org/10.1016/j.mcn.2019.01.003. 10.1016/j.mcn.2019.01.003 Rosa, Alexandra Isabel; Duarte-Silva, Sara; Silva-Fernandes, Anabela; Nunes, Maria João; Carvalho, Andreia Neves; Rodrigues, Elsa; Gama, Maria João; et al. "Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson's Disease". 55 12 (2018): 9139-9155. 10.1007/s12035-018-1062-4 Moreira, Sara; Fonseca, Inês; Nunes, Maria João; Rosa, Alexandra; Lemos, Luísa; Rodrigues, Elsa; Carvalho, Andreia Neves; et al. "Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease". Experimental Neurology 295 (2017): 77-87. http://dx.doi.org/10.1016/j.expneurol.2017.05.009. 10.1016/j.expneurol.2017.05.009 Rosa, Alexandra I.; Fonseca, Inês; Nunes, Maria João; Moreira, Sara; Rodrigues, Elsa; Carvalho, Andreia Neves; Rodrigues, Cecília M.P.; Gama, Maria João; Castro-Caldas, Margarida. "Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863 9 (2017): 2171-2181. http://dx.doi.org/10.1016/j.bbadis.2017.06.004. 10.1016/j.bbadis.2017.06.004 Neves Carvalho, Andreia; Firuzi, Omidreza; Joao Gama, Maria; van Horssen, Jack; Saso, Luciano. "Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope?". Current Drug Targets 18 6 (2017): 705-718. http://dx.doi.org/10.2174/1389450117666160401120514. 10.2174/1389450117666160401120514 Carvalho, Andreia Neves; Marques, Carla; Guedes, Rita C.; Castro-Caldas, Margarida; Rodrigues, Elsa; van Horssen, Jack; Gama, Maria João. "S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection". FEBS Letters 590 10 (2016): 1455-1466. http://dx.doi.org/10.1002/1873-3468.12177. 10.1002/1873-3468.12177 Carvalho, Andreia N; Lim, Jamie L; Nijland, Philip G; Witte, Maarten E; Van Horssen, Jack. "Glutathione in multiple sclerosis: More than just an antioxidant?". Multiple Sclerosis Journal 20 11 (2014): 1425-1431. http://dx.doi.org/10.1177/1352458514533400. 10.1177/1352458514533400 Carvalho, Andreia Neves; Marques, Carla; Rodrigues, Elsa; Henderson, Colin J.; Wolf, C. Roland; Pereira, Paulo; Gama, Maria João. "Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice". Molecular Neurobiology 47 2 (2012): 662-672. http://dx.doi.org/10.1007/s12035-012-8368-4. 10.1007/s12035-012-8368-4 Castro-Caldas, M.; Carvalho, A. Neves; Rodrigues, E.; Henderson, C. J.; Wolf, C. R.; Rodrigues, C. M. P.; Gama, M. J.. "Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease". Molecular Neurobiology 46 2 (2012): 475-486. http://dx.doi.org/10.1007/s12035-012-8295-4. 10.1007/s12035-012-8295-4 Castro-Caldas, Margarida; Carvalho, Andreia Neves; Rodrigues, Elsa; Henderson, Colin; Wolf, C. Roland; Gama, Maria João. "Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway". Molecular Neurobiology 45 3 (2012): 466-477. http://dx.doi.org/10.1007/s12035-012-8266-9. 10.1007/s12035-012-8266-9 Castro-Caldas, Margarida; Carvalho, Andreia Neves; Peixeiro, Isabel; Rodrigues, Elsa; Lechner, Maria Celeste; Gama, Maria Joao. "GSTpi Expression in MPTP-Induced Dopaminergic Neurodegeneration of C57BL/6 Mouse Midbrain and Striatum". Journal of Molecular Neuroscience 38 2 (2009): 114-127. http://hdl.handle.net/10451/21153. Published • http://dx.doi.org/10.1007/s12031-008-9141-z Gama, Maria J.; Castro-Caldas, Margarida; Carvalho, Andreia Neves; Rodrigues, Elsa; Henderson, Colin J.; Wolf, C. Roland. "GSTpi Mediates MPTP-induced JNK Activation in the Nigrostriatal Pathway". Drug Metabolism Reviews (2009): https://publons.com/wos-op/publon/6800219/.
Thesis / Dissertation	Carvalho, Andreia Margarida Gonçalves das Neves, 1982-. "Role of glutathione s-transferase pi in neuronal protection under oxidative stress and proteasome inhibition relevance to Parkinson’s disease". PhD, 2012. http://hdl.handle.net/10451/7425.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2025/09/30	NRF2 crosstalk with the Unfolded Protein Response in Parkinson´s Disease: role in Redox Homeostasis and Proteostasis Restoration.	Redox Webinar - NRF2 and Aging: Proteostasis and Redox Imbalance, High-Level Webinar Series (HLWS) 2025 on Redox Biochemistry, Physiology & Pharmacology BenBedPhar COST action (https://benbedphar.org/webinars/) and Sapienza University of Rome (https://www.antiox.it/home-redox)
2018/12/14	Glutathione S-transferase pi: more than "just" a detoxification enzyme	iMED.ULisboa Post-doc Seminar Series iMED.ULisboa, Faculty of Pharmacy, University of Lisbon (Lisbon, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2022 - Current	CYP46A1-dependent regulation of neuronal intracellular traffic Co-supervisor	Farmácia Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023	Antioxidant and anti-inflammatory potential of polyphenols and derived metabolites in Parkinson's disease Supervisor	Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023	Redox regulation of mitochondrial dynamics and function in Parkinson's disease Supervisor	Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2022	S-glutathionylation of mitofusin 2 in the regulation of mitochondrial (dys)function in Parkinson´s Disease Supervisor
2020 - 2021	Signaling Pathways and players activated upon neuronal mitochondrial dysfunction and involved in antioxidant response - specific role of PGC-1a isoforms Co-supervisor	Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019	Small molecule PGC-1alpha activators: a novel class of anti-neurodegenerative therapeutics Co-supervisor	Mestrado em Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	Interplay of Endoplasmic Reticulum Stress and Autophagy in Parkinson's Disease Co-supervisor	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014	The role of glutathione in Multiple Sclerosis Supervisor	Master Programme in Neurobiology (Master) Universiteit van Amsterdam, Netherlands

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019 - 2019	11th International Meeting of Portuguese Society for Stem Cells and Cell Therapy (2019) (Member of the organizing committee) (2018 - 2019/10) Congress (Member of the Organising Committee)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2010 - 2010	2nd Post-Graduate iMED.UL Students Meeting (2010) (Member of the organizing committee) (2010 - 2010) Symposium (Member of the Organising Committee)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2021 - 2025	COST action CA20121 Bench to Bedside transition for Pharmacological regulation of NRF2 in non-communicable diseases Other
2009 - 2024	International Brain Awareness Week (Science and Society Outreaching Activity) Participation in educational activities for the general public that include seminars/lectures, lab tours and classroom/school visits.
2020 - 2020	Descobre a ULisboa - Como manter o stress oxidativo afastado? O papel dos antioxidantes na saúde (Science and Society Outreaching Activity) Communication at interactive exhibition for students	Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2019	Científicamente Provável - O Cérebro e as Drogas (Science and Society Outreaching Activity) Educational activities for students	Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016	Discovering the Brain! funded by the Dana Alliance for Brain Initiatives & Federation of European Neuroscience Societies (FENS) (Science and Society Outreaching Activity) Participation as a team member in the project. Coordinator: M Castro-Caldas
2013 - 2013	MS Research Days 2013, Hasselt, Belgium (Science and Society Outreaching Activity) The MS Research Days initiative consists in an annual meeting of people working in MS Research in The Netherlands and Belgium, where recent findings and current research in the area are presented and discussed not only with other researchers but also, and maybe more importantly, with MS patients
2012 - 2012	MS Research Days 2012, Doorwerth, The Netherlands (Science and Society Outreaching Activity) The MS Research Days initiative consists in an annual meeting of people working in MS Research in The Netherlands and Belgium, where recent findings and current research in the area are presented and discussed not only with other researchers but also, and maybe more importantly, with MS patients	MS Research Days 2012

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2025	Avaliação do Impacto da Desregulação Específica dos Tióis Mitocondriais num Modelo Periférico de Esclerose Lateral Amiotrófica – Identificação de Potenciais Biomarcadores de Diagnóstico (Thesis) Main arguer	Mariana Alexandre Fernandes (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2025	Diagnostic and Therapeutic Potential of Insulin Degrading Enzyme in Parkinson’s Disease: Human Brain and Mouse Model Studies (Thesis) Main arguer	Camila Maria Piscarreta Lopes (Master) Universidade Nova de Lisboa Medical School, Portugal
2024	Testing new NRF2 activators in an AMD mouse model (Thesis) Main arguer	Shuvajit-Rakshit (Master) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023	Development of a screening pipeline to identify modulators of Nrf2 activity (Thesis) Main arguer	Margarida Isabel Lopes Pedro (Master) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2023	Do berries mediate the formation of advanced glycation end products in MPTP mouse model of Parkinson's disease? (Thesis) Main arguer	Horácio Jesus (Other) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2022	Assess neurometabolic dysfunction and edit mitochondrial genome in the context of Leigh Syndrome by using induced pluripotent stem cell models (Thesis) Arguer	Ricardo Barradas Pereira (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022	The role of GSH signaling in mitophagy induced by reactive oxygen species: potential target for neuroprotection in stroke? (Thesis) Main arguer	Diana Sofia Ferreira Tavares (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021	Exploring the neuroprotective role of miR-335 in experimental Parkinson's Disease (Thesis) Arguer	Ana Cecília Moita do Rosário Lúcio (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021	Molecular effects of low molecular weight (poly)phenol metabolites in human neurons (Thesis) Main arguer	Matilde Taborda Martins (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016	ER stress in Parkinson's Disease (Thesis) Arguer	Miguel de Almeida Santos (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal

Committee member

	Activity description Role	Institution / Organization
2010 - 2011	Founding member of the iMED.UL Post-Graduate Students Commission (2010/2011) Member	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2026 - Current	PhD Advanced Course: Multi-Omics Technologies in Precision Medicine	(Curso de doutoramento (conclusão de unidades curriculares))
2025 - 2026	Molecular Biology
2021 - 2026	Pharmacogenomics	Master Course in Pharmaceutical Sciences (integrated) - MICF (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2026	PhD Advanced Course: Redox Signaling and Redox System in Health and Disease	(Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2025	PhD Advanced Course: Molecular Biomarkers and Technologies	(Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025	Cellular Biology	Master Course in Pharmaceutical Sciences (MICF) (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2025	Biochemistry II	Master Course in Pharmaceutical Sciences (MICF) (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2022	Experimental Design in Research and Innovation	Master Course in Biopharmaceutical Sciences (MCBF) (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2018	Eukaryotic gene regulation and functional genetics	Master Course in Biopharmaceutical Sciences (MCBF) (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014	Allergy & Autoimmunity	Biomedical Sciences and Health & Life Sciences (Bachelor)	Vrije Universiteit Amsterdam, Netherlands

Evaluation committee

	Activity description Role	Institution / Organization
2025 - 2025	External Expert and Rapporteur of the COST Association evaluation of proposals for the Open Call OC-2025-1, European Union
2018 - 2018	Grant reviewer for the Multiple Sclerosis Society, United Kingdom Evaluator	Multiple Sclerosis Society, United Kingdom
2016 - 2017	Evaluation of post-doctoral fellowships for the Research Foundation Flanders (FWO), Belgium Evaluator	Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium

Journal scientific committee

	Journal title (ISSN)	Publisher
2023 - Current	Review Editor on the Editorial Board of Frontiers in Aging Neuroscience - speciality section Cellular and Molecular Mechanisms of Brain-Aging
2022/03/01 - Current	Review Editor on the Editorial Board of Frontiers in Pharmacology - Neuropharmacology	Frontiers
2022 - Current	Review Editor on the Editorial Board of Frontiers in Neuroscience - Neuropharmacology	Frontiers
2020 - Current	Member of the Reviewer Board of Cells (2073-4409)	MDPI
2020 - Current	Member of the reviewer board of Antioxidants (2076-3921)
2023 - 2024	Guest Associate Editor - Antioxidants "Protein Oxidative Modification in Brain Function, Brain Ageing and Neurological Diseases"
2021 - 2023	Guest associate editor Research Topic Frontiers in Cellular Neuroscience - Cellular Neuropathology "Redox-Signalling in Neurodegenerative Diseases: Biomarkers, Targets, and Therapies"	Frontiers

Distinctions

Other distinction

2022	Fellowship/ Travel grant to attend the EMBO practical course "Characterisation of post-translational modifications in cellular signalling" (Odense, Denmark 2022)
2015	Fellowship/Travel grant to attend the 31st ECTRIMS Congress (Spain 2015) European Committee for Treatment and Research in Multiple Sclerosis, Switzerland
2014	Fellowship - Young Scientist Program - 23rd IUBMB and 44th SBBq Congress (Brazil 2015) International Union of Biochemistry and Molecular Biology, Canada
2012	DuPré Grant Multiple Sclerosis International Federation, United Kingdom
2012	ECTRIMS Postdoctoral Research Fellowship European Committee for Treatment and Research in Multiple Sclerosis, Switzerland