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Identification

Personal identification

Full name
LUCIA COPPO

Citation names

  • COPPO, LUCIA

Author identifiers

Ciência ID
A51C-D234-7CC6
ORCID iD
0000-0001-6902-6346

Languages

Language Speaking Reading Writing Listening Peer-review
Italian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2012
Concluded
 PhD in Molecular Medicine with Doctor Europeaus Award (Doutoramento)
Università degli Studi di Siena - Presidio San Miniato, Italy
"Redox Modifications of Protein Thiols" (THESIS/DISSERTATION)
 Approved
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - Current Researcher (Research) Karolinska Institutet, Sweden
Karolinska Institutet, Sweden

Others

Category
Host institution 		Employer
2012/05/01 - 2018/12/31 Postdoc Karolinska Institutet, Sweden
2013/04/01 - 2013/07/01 Internship CTI-Science/Karolinska Institute/KCLondon King's College London School of Medical Education, United Kingdom
2010/07/01 - 2011/12/01 Visiting student in Brighton and Sussex Medical School Falmer, Brighton Brighton and Sussex Medical School Department of Medical Education, United Kingdom
Outputs

Publications

Journal article
  1. Lucia Coppo; Pradeep Mishra; Nora Siefert; Arne Holmgren; Svante Pääbo; Hugo Zeberg. "A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans". Science Advances 8 1 (2022): https://doi.org/10.1126/sciadv.abm1148.
    10.1126/sciadv.abm1148
  2. Fernando T. Ogata; Vasco Branco; Filipa F. Vale; Lucia Coppo. "Glutaredoxin: Discovery, redox defense and much more". Redox Biology 43 (2021): 101975-101975. https://doi.org/10.1016/j.redox.2021.101975.
    10.1016/j.redox.2021.101975
  3. Colin G. Miller; Jean A. Kundert; Justin R. Prigge; Julie A. Amato; Allison E. Perez; Lucia Coppo; Gabrielle N. Rizzo; et al. "Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption". Antioxidants 10 3 (2021): 359-359. https://doi.org/10.3390/antiox10030359.
    10.3390/antiox10030359
  4. Koh, Wei Xiang; Coppo, Lucia; Holmgren, Arne; Kong, Jia Wen; Leong, Weng Kee. "Inhibition of Thioredoxin Reductase by Triosmium Carbonyl Clusters". Chemical Research in Toxicology 33 9 (2020): 2441-2445. http://dx.doi.org/10.1021/acs.chemrestox.0c00214.
    10.1021/acs.chemrestox.0c00214
  5. Rajib Sengupta; Lucia Coppo; Pradeep Mishra; Arne Holmgren. "Glutathione-glutaredoxin is an efficient electron donor system for mammalian p53R2–R1-dependent ribonucleotide reductase". Journal of Biological Chemistry 294 34 (2019): 12708-12716. https://doi.org/10.1074/jbc.RA119.008752.
    10.1074/jbc.RA119.008752
  6. Ren, Xiaoyuan; Santhosh, Sebastin M.; Coppo, Lucia; Ogata, Fernando T.; Lu, Jun; Holmgren, Arne. "The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress". Free Radical Biology and Medicine 134 (2019): 350-358. http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.037.
    10.1016/j.freeradbiomed.2019.01.037
  7. Coppo, Lucia; Ogata, Fernando T.; Santhosh, Sebastin M.; Sventelius, Teodor; Holmgren, Arne. "Enzymatic glutaredoxin-dependent method to determine glutathione and protein S-glutathionylation using fluorescent eosin-glutathione". Analytical Biochemistry 568 (2019): 24-30. http://dx.doi.org/10.1016/j.ab.2018.12.021.
    10.1016/j.ab.2018.12.021
  8. Haffo, Lena; Lu, Jun; Bykov, Vladimir J. N.; Martin, Sebastin S.; Ren, Xiaoyuan; Coppo, Lucia; Wiman, Klas G.; Holmgren, Arne. "Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-31048-7.
    10.1038/s41598-018-31048-7
  9. Rodriguez-Garcia A; Hevia D; Mayo JC; Gonzalez-Menendez P; Coppo L; Lu J; Holmgren A; Sainz RM. "Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells.". (2017): http://europepmc.org/abstract/med/28391184.
    10.1016/j.redox.2017.03.025
  10. Prigge JR; Coppo L; Martin SS; Ogata F; Miller CG; Bruschwein MD; Orlicky DJ; et al. "Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase.". (2017): http://europepmc.org/abstract/med/28658624.
    10.1016/j.celrep.2017.06.019
  11. Branco V; Coppo L; Solá S; Lu J; Rodrigues CMP; Holmgren A; Carvalho C. "Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury.". (2017): http://europepmc.org/abstract/med/28600984.
    10.1016/j.redox.2017.05.024
  12. Diotallevi, M; Checconi, P; Palamara, AT; Celestino, I; Coppo, L; Holmgren, A; Abbas, K; et al. "Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties". Front. Immunol. (2017): http://www.ncbi.nlm.nih.gov/pubmed/29033950.
    10.3389/fimmu.2017.01239
  13. Ulivelli M; Priora R; Di Giuseppe D; Coppo L; Summa D; Margaritis A; Frosali S; et al. "Homocysteinemia control by cysteine in cerebral vascular patients after methionine loading test: evidences in physiological and pathological conditions in cerebro-vascular and multiple sclerosis patients.". (2016): http://europepmc.org/abstract/med/26969256.
    10.1007/s00726-016-2207-2
  14. Coppo L; Montano SJ; Padilla AC; Holmgren A. "Determination of glutaredoxin enzyme activity and protein S-glutathionylation using fluorescent eosin-glutathione.". (2016): http://europepmc.org/abstract/med/26836485.
    10.1016/j.ab.2016.01.012
  15. Olivera GC; Ren X; Vodnala SK; Lu J; Coppo L; Leepiyasakulchai C; Holmgren A; Kristensson K; Rottenberg ME. "Nitric Oxide Protects against Infection-Induced Neuroinflammation by Preserving the Stability of the Blood-Brain Barrier.". (2016): http://europepmc.org/abstract/med/26915097.
    10.1371/journal.ppat.1005442
  16. Salzano S; Checconi P; Hanschmann EM; Lillig CH; Bowler LD; Chan P; Vaudry D; et al. "Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.". (2014): http://europepmc.org/abstract/med/25097261.
    10.1073/pnas.1401712111
  17. Di Giuseppe D; Priora R; Coppo L; Ulivelli M; Bartalini S; Summa D; Margaritis A; Frosali S; Di Simplicio P. "The control of hyperhomocysteinemia through thiol exchange mechanisms by mesna.". (2014): http://europepmc.org/abstract/med/24337902.
    10.1007/s00726-013-1636-4
  18. Coppo L; Ghezzi P. "Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism.". (2011): http://europepmc.org/abstract/med/21936800.
    10.1042/bst0391268
  19. Priora R; Margaritis A; Frosali S; Coppo L; Summa D; Di Giuseppe D; Aldinucci C; et al. "In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways.". (2011): http://europepmc.org/abstract/med/21539916.
    10.1016/j.phrs.2011.03.014
  20. Margaritis A; Priora R; Frosali S; Di Giuseppe D; Summa D; Coppo L; Di Stefano A; Di Simplicio P. "The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions.". (2011): http://europepmc.org/abstract/med/20883787.
    10.1016/j.phrs.2010.09.004
  21. Priora R; Coppo L; Margaritis A; Di Giuseppe D; Frosali S; Summa D; Heo J; Di Simplicio P. "The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats.". (2010): http://europepmc.org/abstract/med/19909765.
    10.1016/j.taap.2009.11.003
  22. Priora R; Coppo L; Salzano S; Di Simplicio P; Ghezzi P. "Measurement of mixed disulfides including glutathionylated proteins.". (2010): http://europepmc.org/abstract/med/20513476.
    10.1016/s0076-6879(10)73007-x
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/07/01 - Current Main supervisor of a Medical student for the Project degree in medicine
Supervisor of Naixuan Pei
 Medicine (Other)
Karolinska Institutet, Sweden
2019/10/01 - 2019/12/23 Main supervisor of a visiting Bachelor student from Heidelberg University, Germany
Supervisor of Nora Siefert
 Biochemistry (Degree)
Karolinska Institutet, Sweden
2019/07/01 - 2019/09/30 Main supervisor of a visiting PhD student from Ankara University, Turkey
Supervisor
 Biochemistry and Molecular Biology (PhD)
Karolinska Institutet, Sweden
2018/10/01 - 2018/12/23 Main supervisor of a visiting student form University of Bremen, Germany.
Supervisor
 Biochemistry (Degree)
Karolinska Institutet, Sweden

Committee member

Activity description
Role 		Institution / Organization
2020/10/27 - Current Member of the Doctoral Thesis panel. Candidate: Pablo Marti Andres, Department of Physiology Faculty of Pharmacy, Universitat de València Spain
Member
 Karolinska Institutet, Sweden

Universitat de València, Spain
2020/06/12 - Current Member of half-time control committee for the PhD student Mattia Russel Pantalone, Söderberg-Naucler’s lab, Department of Medicine, Karolinska Institute.
Member
 Karolinska Institutet, Sweden
2019/10/11 - Current Member of half-time control committee for the PhD student Pierre Sabatier, Zubarev ‘s lab, MBB Department, Karolinska Institute
Member
 Karolinska Institutet, Sweden
2017/03/24 - Current Member of the Doctoral Thesis panel. Candidate: Cristina Álvarez Zaldiernas. March the 24th 2017 Faculty of Medicine and Health Sciences of the University of Barcelona Spain.
Member
 Universitat de Barcelona Facultat de Medicina i Ciències de la Salut, Spain

Karolinska Institutet, Sweden
Distinctions

Award

2020 Fulbright fellowship
Fulbright Sweden-US Commission, Sweden
2020 EMBO-short term fellowship
EMBO , Germany