Luana Madalena Oliveira da Silva de Sousa (A516-50BD-2AA7)

Curriculum Vitae

Luana Madalena Oliveira da Silva de Sousa

I obtained my BSc and MSc in Biochemistry at the University of Coimbra, Portugal. I performed my master's dissertation at the Laboratory of Immunology and Oncology at the Center for Neuroscience and Cell Biology, University of Coimbra. My dissertation was dedicated to the analysis of the peripheral immune status of trabectedin versus anthracycline-based chemotherapy in soft tissue sarcoma patients. During this time, I presented my work at specialized national and international meetings and published 3 papers, one of them as the first author. After my MSc, I stayed at the Laboratory of Immunology and Oncology as a research assistant and participate in several ongoing projects related to the immune-oncology field. Furthermore, I co-supervised three BSc students.

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Identification

Personal identification

Full name: Luana Madalena Oliveira da Silva de Sousa

Citation names

Sousa, Luana Madalena

Author identifiers

Ciência ID: A516-50BD-2AA7
ORCID iD: 0000-0002-6207-7084

Knowledge fields

Natural sciences - Biological Sciences - Biochemistry
Medical and Health Sciences - Basic Medicine - Immunology
Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Advanced (C1)

Education

	Degree	Classification
2019/09 - 2021/11 Concluded	Bioquímica (Mestrado) Universidade de Coimbra, Portugal "Peripheral immune status of trabectedin versus anthracycline-based chemotherapy in soft tissue sarcoma" (THESIS/DISSERTATION)	18
2016/09 - 2019/06 Concluded	Bioquímica (Licenciatura) Universidade de Coimbra, Portugal	15

Affiliation

Science

	Category Host institution	Employer
2022/01/01 - 2023/08/30	Research Assistant (Research)	Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia, Portugal
	Laboratório de Imunologia e Oncologia, CNC, Universidade de Coimbra, Portugal
2021/09/01 - 2021/09/30	Research Trainee (Research)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Projects

Grant

	Designation	Funders
2022/12 - Current	Kinder-GUT: Role of diet-derived retinoids in CD8aa intraepithelial lymphocytes and intestinal defence at early-life HR22-00754 Researcher Universidade de Coimbra, Portugal	Fundació Caixa d' Estalvis de Catalunya Ongoing
2022/09 - 2023/08	COMP-S: Cultivating Compassionate Schools: The effects of an evidence-based compassionate mind training program for teachers on psychophysiological and epigenetic correlates of wellbeing, prosociality and stress PT/FB/BL-2022-074 Researcher Universidade de Coimbra, Portugal	Fundação Bial Ongoing

Contract

	Designation	Funders
2022/01 - Current	IMMUNYON: Immune Monitoring of Trabectedin (Yondelis®) Therapy In Refractory Soft Tissue Sarcoma Patients IMMUNYON-CIMAGO12/18 Researcher Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia, Portugal	PharmaMar SA Ongoing
2022/01 - Current	MirAE - Immune-related adverse events of immune checkpoint inhibitors in metastatic melanoma - phenotypes and biomarkers MirAE Researcher Universidade de Coimbra Faculdade de Medicina, Portugal	Banco Santander Portugal Ongoing
2021/03/15 - Current	Helicobacter Pylori Eradication Therapy in Portugal: Prospective, randomized, blind and multicentre trial on the efficacy of quadruple therapies and their clinical impact and immunological, oral and gut microbiota changes PTDC/MEC-GAS/7361/2020 Researcher Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Other

	Designation	Funders
2022/01 - Current	LUCA-IMMUNE - Immune monitoring of immune checkpoint inhibitors therapy in stage IIIb/IV Non-Small Cell Lung Cancer patients LUCA-IMMUNE Researcher Laboratório de Imunologia e Oncologia, CNC, Universidade de Coimbra, Portugal	Ongoing

Outputs

Publications

Conference poster	Almeida, Jani Sofia; Sousa, Luana Madalena; Rodrigues, Joana; Fonseca, Ruben; Alves, Vera; Santos-Rosa, Manuel; Freitas-Tavares, Paulo; Casanova, José Manuel; Rodrigues-Santos, Paulo. "Upregulation of Double Negative gdTCR NKT-like cells In Soft Tissue Sarcoma Patients". Paper presented in XLVIII SPI Annual Meeting 2023, 2023. Sousa, Luana Madalena; Almeida, Jani Sofia; Rodrigues, Joana; Fonseca, Ruben; Freitas-Tavares, Paulo; Casanova, José Manuel; Santos-Rosa, Manuel; Rodrigues-Santos, Paulo. "Perfil imune periférico em doentes com sarcoma de tecidos moles submetidos a quimioterapias baseadas em trabectedina versus antraciclinas". Paper presented in Congresso Nacional de Oncologia, 2022. Pratas, Edgar; Sousa, Luana Madalena; Almeida, Jani Sofia; Regateiro, Frederico; Vieira, Ricardo; Gonçalo, Margarida; Rodrigues-Santos, Paulo. "Anti-PD1 treatment of melanoma induces early changes in peripheral lymphocyte subsets". Paper presented in ESMO (European Society for Medical Oncology) Congress 2022, 2022. Pratas, Edgar; Sousa, Luana Madalena; Almeida, Jani Sofia; Regateiro, Frederico ; Vieira, Ricardo; Gonçalo, Margarida; Rodrigues-Santos, Paulo. "Early changes in immune cell populations after anti-PD1 treatment of melanoma". Paper presented in 18th Congress of the European Association of Dermato-Oncology (EADO), 2022. Sousa, Luana Madalena; Almeida, Jani Sofia; Fortes-Andrade, Tânia; Martinho, Antonio; Santos-Rosa, Manuel; Rodrigues, Joana; Fonseca, Ruben; et al. "Peripheral immune status of trabectedin versus anthracycline-based chemotherapy in Soft Tissue Sarcoma". Paper presented in XLVII SPI Annual Meeting 2022, 2022. Rodrigues-Santos, Paulo; Almeida, Jani Sofia; Fortes-Andrade, Tânia; Sousa, Luana Madalena; Couceiro, Patrícia; Rodrigues, Joana; Fonseca, Ruben; Freitas-Tavares, Paulo; Casanova, José Manuel. "Receptor repertoire and functional analysis of Natural Killer cells in Soft Tissue Sarcoma patients". Paper presented in XLVII SPI Annual Meeting 2022, 2022. Almeida, Jani Sofia; Couceiro, Patrícia; Sousa, Luana Madalena; Fortes-Andrade, Tânia; Rodrigues, Joana; Fonseca, Ruben; Freitas-Tavares, Paulo; Casanova, José Manuel; Rodrigues-Santos, Paulo. "Peripheral immune profiling and survival of Soft Tissue Sarcoma patients". Paper presented in XLVII SPI Annual Meeting 2022, 2022. Rodrigues-Santos, Paulo; Almeida, Jani Sofia; Sousa, Luana Madalena; Barata, Fernando; Figueiredo, Ana; Santos-Rosa, Manuel. "Cellular and plasmatic immune profile of anti-PD-1 therapy in phase IIIB/IV non-small cell lung cancer: relevance of immunosuppressive factors". Paper presented in XLVII SPI Annual Meeting 2022, 2022. Sousa, Luana Madalena; Almeida, Jani Sofia; Fortes-Andrade, Tânia; Santos-Rosa, Manuel; Rodrigues, Joana; Fonseca, Ruben; Freitas-Tavares, Paulo; Casanova, José Manuel; Rodrigues-Santos, Paulo. "Peripheral immune profiling of soft tissue sarcoma: comparison between trabectedin and anthracycline-based chemotherapy". Paper presented in STRATAGEM - Annual Conference, 2022. Almeida, Jani-Sofia; Paulo Rodrigues-Santos; Couceiro, Patrícia; Sousa, Luana Madalena; Fortes-Andrade, Tânia ; Fonseca, Rúben; Santos-Rosa, Manuel; Freitas-Tavares, Paulo; Casanova, José Manuel. "Peripheral Immune Landscape of Soft Tissue Sarcoma: Cellular, Proteomic and Transcriptomic Analysis". Paper presented in Annual Congress Connective Tissue Oncology Society (CTOS), 2021. Rodrigues-Santos, Paulo; Almeida, Jani-Sofia; Couceiro, Patrícia; Sousa, Luana Madalena; Fortes-Andrade, Tânia ; Fonseca, Rúben; Freitas-Tavares, Paulo; Casanova, José Manuel; Santos-Rosa, Manuel. Corresponding author: Rodrigues-Santos, Paulo. "Comprehensive immunophenotyping and soluble proteome analysis of soft tissue sarcoma patients define association with functionally distinct lymphocyte subsets and major suppressor cells". Paper presented in Reunião Anual da Sociedade Portuguesa de Imunologia (SPI), 2021.
Journal article	Casanova, José Manuel; Almeida, Jani-Sofia; Reith, John David; Sousa, Luana Madalena; Fonseca, Ruben; Freitas-Tavares, Paulo; Santos-Rosa, Manuel; Rodrigues-Santos, Paulo. "Tumor-Infiltrating Lymphocytes and Cancer Markers in Osteosarcoma: Influence on Patient Survival". Cancers 13 23 (2021): 6075. Published • 10.3390/cancers13236075 Sousa, Luana Madalena; Almeida, Jani Sofia; Fortes-Andrade, Tânia; Santos-Rosa, Manuel; Freitas-Tavares, Paulo; Casanova, José Manuel; Rodrigues-Santos, Paulo. "Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy". Cancers 13 15 (2021): 3885. Published • 10.3390/cancers13153885 Fortes-Andrade, Tânia; Almeida, Jani-Sofia; Sousa, Luana Madalena; Santos-Rosa, Manuel; Freitas-Tavares, Paulo; Casanova, José Manuel; Rodrigues-Santos, Paulo. "The role of natural killer cells in soft tissue sarcoma: Prospects for immunotherapy". Cancers 13 15 (2021): Published • 10.3390/cancers13153865
Thesis / Dissertation	"Peripheral Immune Status of Trabectedin versus Anthracycline-based Chemotherapy in Soft Tissue Sarcoma". Master, Universidade de Coimbra, 2021.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/11	Repertório e análise funcional de células Natural Killer periféricas em doentes com Sarcoma de Tecidos Moles	Congresso Nacional de Oncologia Sociedade Portuguesa de Oncologia (Porto, Portugal)
2022/11	Perfil imunológico periférico como fator preditivo da sobrevivência global de doentes com Sarcoma de Tecido Moles	Congresso Nacional de Oncologia Sociedade Portuguesa de Oncologia (Portugal)
2021/09	Immune profiling of soft tissue sarcoma: cellular, proteomic and transcriptomic analysis of peripheral blood	6th European Congress of Immunology (ECI)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/03/07 - 2023/06/08	Flow Cytometry and Cell Sorting Course (2023/03/07) Workshop (Co-organisor)	Universidade de Coimbra, Portugal
2020 - 2020	First edition of "Olimpíadas Universitárias da Bioquímica", at Coimbra University. (2020 - 2020) Call (Member of the Organising Committee)	Universidade de Coimbra, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2023/03/29 - 2023/03/31	XLVIII SPI Annual Meeting 2023 Conference	XLVIII SPI Annual Meeting 2023 Sociedade Portuguesa de Imunologia, Portugal
2022/05/02 - 2022/05/03	Full Spectrum Flow Cytometry Course Workshop	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/04/26 - 2022/04/27	Seahorse XF Analyzers Agilent Cell Analysis Seminar & Workshop Seminar	Universidade de Coimbra, Portugal
2022/04/20 - 2022/04/22	Applications of Flow Cytometry in Immune monitoring, workshop of the Iberian Flow Cytometry Society (SIC) Workshop	Universidade Nova de Lisboa, Portugal
2021/04/20 - 2021/04/30	"Campanha Conversas com Cientistas - Décadas de Ciência para Dias de Vacinas" promoted conversations between scientists and the public about COVID-19 vaccines. Other	Conversas com Cientistas - Décadas de Ciência para Dias de Vacinas Ciência Viva, Portugal
2019/04/12 - 2019/04/15	XII Encontro Nacional de Estudantes de Bioquímica, organized by Núcleo de Estudantes de Química da Associação Académica da Universidade de Aveiro. Meeting	XII ENEBIOQ - Bioquímica à Beira Rio Universidade de Aveiro, Portugal
2019/04/12 - 2019/04/15	Animal Experimentation workshop, guided by Fátima Camões, at the XII Encontro Nacional de Estudantes de Bioquímica, at Universidade de Aveiro Workshop	Animal Experimentation Universidade de Aveiro, Portugal
2019/04/12 - 2019/04/15	Science Communication workshop at the XII Encontro Nacional de Estudantes de Bioquímica Workshop	Science Communication Universidade de Aveiro, Portugal
2018/03/23 - 2018/03/26	XI Encontro Nacional de Estudantes de Bioquímica, organized by Núcleo de Estudantes de Bioquímica da Universidade do Porto. Meeting	XI ENEBIOQ - Décima primeira edição de Encontro Nacional de Estudantes de Bioquímica Universidade do Porto, Portugal
2018 - 2018	'Bioterrorismo - Armas Biológicas e Segurança Internacional' conference organized by Núcleo de Estudantes de Bioquímica da Associação Académica de Coimbra. Conference	Bioterrorismo - Armas Biológicas e Segurança Internacional Universidade de Coimbra, Portugal
2017/04/07 - 2017/04/10	X Encontro Nacional de Estudantes de Bioquímica, organized by Núcleo de Estudantes de Bioquímica da Universidade do Minho. Meeting	X ENEBIOQ - A Ciência nas tuas mãos Universidade do Minho, Portugal

Association member

	Society Organization name	Role
2022 - Current	Juventude Social Democrata Distrital de Leiria	Membro do Gabinete de Estudos
2020 - Current	Associação de Bombeiros Voluntários de Óbidos.	Bombeira Voluntária
2020 - Current	Juventude Social Democrata de Óbidos	Coordenadora de Formação
2019 - Current	Associação Musical Sinfonietta de Óbidos	Secretária e Violoncelista
2018 - Current	Associação Musical União Filarmónica da A-da-Gorda	Violoncelista
2016 - Current	Grupo de Jovens das Paróquias de Óbidos	Membro
2016 - Current	Grupo de Danças Antigas Josefa d'Óbidos	Violoncelista
2018 - 2019	Núcleo de Estudantes de Bioquímica da Universidade de Coimbra	Coordenadora do Pelouro de Intervenção Cívica e Ambiental
2017 - 2018	Núcleo de Estudantes de Bioquímica	Membro do Pelouro de Intervenção Cívica e Ambiental

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2023/03/07 - 2023/03/08	Flow Cytometry and Cell Sorting Course	(Curso de Especialização Tecnológica)	Universidade de Coimbra, Portugal

Mentoring / Tutoring

	Topic	Student name
2023/02 - 2023/06	BSc internship	Inês Vitorino
2023/02 - 2023/06	BSc internship	Bruna Martins
2023/02 - 2023/06	BSc internship	Beatriz Lima

Scientific expedition

	Activity description	Institution / Organization
2017 - Current	Participation in scientific didactic experiences in a voluntary visit to the Hospital Pediátrico de Coimbra, organized by the association MiniBioqs	Universidade de Coimbra, Portugal

Distinctions

Award

2022	1st Prize Best Poster Presentation Stratagem Inc, United States
2022	Best Poster Prize Sociedade Portuguesa de Oncologia, Portugal
2022	Best Oral Presentation Prize Sociedade Portuguesa de Oncologia, Portugal