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Identification

Personal identification

Full name
Noora Kotaja

Citation names

  • Kotaja, Noora

Author identifiers

Ciência ID
A41F-73BE-397F
ORCID iD
0000-0003-1503-9170
Education
Degree Classification
2003/01/21
Concluded
 PhD (Doktor (PhD))
Major in Biomedicine
Helsingin yliopisto, Finland
1999/06/17
Concluded
 MSc (Master)
Major in Molecular biology
Jyvaskylan Yliopisto, Finland
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2020/08/01 - Current Full Professor (University Teacher) Turun Yliopisto, Finland
Turun Yliopisto, Finland
Projects

Grant

Designation Funders
2018/09/01 - Current Germ granules: key regulators of male fertility, epigenetic inheritance and cancer
315948
Principal investigator
Ongoing
2018/01/01 - Current PROGERM - Prevention of metabolic diseases by protecting the male germline epigenome
314387
Principal investigator
Ongoing
Outputs

Publications

Book
  1. Parvinen, M.; Kotaja, N.; Mishra, D.P.; Sassone-Corsi, P.. The chromatoid body and microRNA pathways in male germ cells. 2007.
    10.1007/978-1-59745-176-5_12
Journal article
  1. Andreas Werner; James E. Clark; Calum Samaranayake; John Casement; Hany S. Zinad; Shaymaa Sadeq; Surar Al-Hashimi; et al. "Widespread formation of double-stranded RNAs in testis". Genome Research 31 7 (2021): 1174-1186. https://doi.org/10.1101/gr.265603.120.
    10.1101/gr.265603.120
  2. Mäkelä Juho-Antti; Cisneros-Montalvo Sheyla; Lehtiniemi Tiina; Olotu Opeyemi; La Hue M; Toppari Jorma; Hobbs Robin M; Parvinen Martti; Kotaja Noora. "Transillumination-Assisted Dissection of Specific Stages of the Mouse Seminiferous Epithelial Cycle for Downstream Immunostaining Analyses". Journal of Visualized Experiments (2020):
    10.3791/61800
  3. Ram Prakash Yadav; Juho-Antti Mäkelä; Hanna Hyssälä; Sheyla Cisneros-Montalvo; Noora Kotaja. "DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis". Nucleic Acids Research (2020): https://doi.org/10.1093/nar/gkaa460.
    10.1093/nar/gkaa460
  4. P. Sipilä; A. Junnila; J. Hakkarainen; R. Huhtaniemi; L. Mairinoja; F.P. Zhang; L. Strauss; et al. "The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency". FASEB Journal (2020):
    10.1096/fj.201902384R
  5. Da Ros M.; Lehtiniemi T.; Olotu O.; Meikar O.; Kotaja N.. "Enrichment of Pachytene Spermatocytes and Spermatids from Mouse Testes Using Standard Laboratory Equipment". Journal of Visualized Experiments (2019):
    10.3791/60271
  6. Zhang FP; Malinen M; Mehmood A; Lehtiniemi T; Jääskeläinen T; Niskanen EA; Korhonen H; et al. "Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction". Nature Communications 10 (2019):
    10.1038/s41467-019-08730-z
  7. Pandey RR; Homolka D; Olotu O; Sachidanandam R; Kotaja N; Pillai RS. "Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12.". Cell reports (2018): http://europepmc.org/abstract/med/30257204.
    10.1016/j.celrep.2018.08.087
  8. Hakkarainen J; Zhang FP; Jokela H; Mayerhofer A; Behr R; Cisneros-Montalvo S; Nurmio M; et al. "Hydroxysteroid (17ß) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility.". FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2018): http://europepmc.org/abstract/med/29401623.
    10.1096/fj.201700921r
  9. Lehtiniemi T; Kotaja N. "Germ granule-mediated RNA regulation in male germ cells.". Reproduction (Cambridge, England) (2018): http://europepmc.org/abstract/med/29038333.
    10.1530/rep-17-0356
  10. Lehti MS; Henriksson H; Rummukainen P; Wang F; Uusitalo-Kylmälä L; Kiviranta R; Heino TJ; Kotaja N; Sironen A. "Cilia-related protein SPEF2 regulates osteoblast differentiation.". Scientific reports (2018): http://europepmc.org/abstract/med/29339787.
    10.1038/s41598-018-19204-5
  11. Lehti MS; Zhang FP; Kotaja N; Sironen A. "SPEF2 functions in microtubule-mediated transport in elongating spermatids to ensure proper male germ cell differentiation.". Development (Cambridge, England) (2017): http://europepmc.org/abstract/med/28619825.
    10.1242/dev.152108
  12. Da Ros M; Lehtiniemi T; Olotu O; Fischer D; Zhang FP; Vihinen H; Jokitalo E; et al. "FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules.". Autophagy (2017): http://europepmc.org/abstract/med/27929729.
    10.1080/15548627.2016.1261319
  13. Korhonen HM; Yadav RP; Da Ros M; Chalmel F; Zimmermann C; Toppari J; Nef S; Kotaja N. "DICER Regulates the Formation and Maintenance of Cell-Cell Junctions in the Mouse Seminiferous Epithelium.". Biology of reproduction (2015): http://europepmc.org/abstract/med/26510868.
    10.1095/biolreprod.115.131938
  14. Lehti MS; Kotaja N; Sironen A. "KIF1-binding protein interacts with KIF3A in haploid male germ cells.". (2015): http://europepmc.org/abstract/med/26245936.
    10.1530/REP-15-0173
  15. Goh WS; Falciatori I; Tam OH; Burgess R; Meikar O; Kotaja N; Hammell M; Hannon GJ. "piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.". (2015): http://europepmc.org/abstract/med/25995188.
    10.1101/gad.260455.115
  16. Da Ros, M.; Hirvonen, N.; Olotu, O.; Toppari, J.; Kotaja, N.. "Retromer vesicles interact with RNA granules in haploid male germ cells". Molecular and Cellular Endocrinology 401 (2015): 73-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919935421&partnerID=MN8TOARS.
    10.1016/j.mce.2014.11.026
  17. Meikar, O.; Kotaja, N.. "Isolation of chromatoid bodies from mouse testis as a rich source of short RNAs". Methods in molecular biology (Clifton, N.J.) 1173 (2014): 11-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922482125&partnerID=MN8TOARS.
    10.1007/978-1-4939-0931-5_2
  18. Kotaja, N.. "MicroRNAs and spermatogenesis". Fertility and Sterility 101 6 (2014): 1552-1562. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901712439&partnerID=MN8TOARS.
    10.1016/j.fertnstert.2014.04.025
  19. Meikar, O.; Vagin, V.V.; Chalmel, F.; Sõstar, K.; Lardenois, A.; Hammell, M.; Jin, Y.; et al. "An atlas of chromatoid body components". RNA 20 4 (2014): 483-495. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896538092&partnerID=MN8TOARS.
    10.1261/rna.043729.113
  20. Yadav, R.P.; Kotaja, N.. "Small RNAs in spermatogenesis". Molecular and Cellular Endocrinology 382 1 (2014): 498-508. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888295796&partnerID=MN8TOARS.
    10.1016/j.mce.2013.04.015
  21. Rotgers, E.; Rivero-Müller, A.; Nurmio, M.; Parvinen, M.; Guillou, F.; Huhtaniemi, I.; Kotaja, N.; Bourguiba-Hachemi, S.; Toppari, J.. "Retinoblastoma protein (RB) interacts with E2F3 to control terminal differentiation of Sertoli cells". Cell Death and Disease 5 6 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903774512&partnerID=MN8TOARS.
    10.1038/cddis.2014.232
  22. Zimmermann, C.; Romero, Y.; Warnefors, M.; Bilican, A.; Borel, C.; Smith, L.B.; Kotaja, N.; Kaessmann, H.; Nef, S.. "Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility". PLoS ONE 9 9 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84907190331&partnerID=MN8TOARS.
    10.1371/journal.pone.0107023
  23. Meikar O; Da Ros M; Kotaja N. "Epigenetic regulation of male germ cell differentiation.". (2013): http://europepmc.org/abstract/med/23150249.
    10.1007/978-94-007-4525-4_6
  24. Lehti, M.S.; Kotaja, N.; Sironen, A.. "KIF3A is essential for sperm tail formation and manchette function". Molecular and Cellular Endocrinology 377 1-2 (2013): 44-55. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880448771&partnerID=MN8TOARS.
    10.1016/j.mce.2013.06.030
  25. Laiho, A.; Kotaja, N.; Gyenesei, A.; Sironen, A.. "Transcriptome Profiling of the Murine Testis during the First Wave of Spermatogenesis". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876247905&partnerID=MN8TOARS.
    10.1371/journal.pone.0061558
  26. Messina, V.; Meikar, O.; Paronetto, M.P.; Calabretta, S.; Geremia, R.; Kotaja, N.; Sette, C.. "The RNA binding protein SAM68 transiently localizes in the chromatoid body of male germ cells and influences expression of select microRNAs". PLoS ONE 7 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862668751&partnerID=MN8TOARS.
    10.1371/journal.pone.0039729
  27. Meikar, O.; Da Ros, M.; Korhonen, H.; Kotaja, N.. "Chromatoid body and small RNAs in male germ cells". Reproduction 142 2 (2011): 195-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960652605&partnerID=MN8TOARS.
    10.1530/REP-11-0057
  28. Sironen, A.; Kotaja, N.; Mulhern, H.; Wyatt, T.A.; Sisson, J.H.; Pavlik, J.A.; Miiluniemi, M.; Fleming, M.D.; Lee, L.. "Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia". Biology of Reproduction 85 4 (2011): 690-701. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955139537&partnerID=MN8TOARS.
    10.1095/biolreprod.111.091132
  29. Korhonen, H.M.; Meikar, O.; Yadav, R.P.; Papaioannou, M.D.; Romero, Y.; da Ros, M.; Herrera, P.L.; et al. "Dicer is required for haploid male germ cell differentiation in mice". PLoS ONE 6 9 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052856592&partnerID=MN8TOARS.
    10.1371/journal.pone.0024821
  30. Romero, Y.; Meikar, O.; Papaioannou, M.D.; Conne, B.; Grey, C.; Weier, M.; Pralong, F.; et al. "Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects". PLoS ONE 6 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053614178&partnerID=MN8TOARS.
    10.1371/journal.pone.0025241
  31. Meikar, O.; Da Ros, M.; Liljenbäck, H.; Toppari, J.; Kotaja, N.. "Accumulation of piRNAs in the chromatoid bodies purified by a novel isolation protocol". Experimental Cell Research 316 9 (2010): 1567-1575. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952891667&partnerID=MN8TOARS.
    10.1016/j.yexcr.2010.02.023
  32. Sironen, A.; Hansen, J.; Thomsen, B.; Andersson, M.; Vilkki, J.; Toppari, J.; Kotaja, N.. "Expression of SPEF2 during Mouse Spermatogenesis and Identification of IFT20 as an Interacting Protein". Biology of Reproduction 82 3 (2010): 580-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953109554&partnerID=MN8TOARS.
    10.1095/biolreprod.108.074971
  33. Björk, J.K.; Sandqvist, A.; Elsing, A.N.; Kotaja, N.; Sistonen, L.. "miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis". Development 137 19 (2010): 3177-3184. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956573979&partnerID=MN8TOARS.
    10.1242/dev.050955
  34. Lardenois, A.; Chalmel, F.; Demougin, P.; Kotaja, N.; Sassone-Corsi, P.; Primig, M.. "Fhl5/Act, a CREM-binding transcriptional activator required for normal sperm maturation and morphology, is not essential for testicular gene expression". Reproductive Biology and Endocrinology 7 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-71949110134&partnerID=MN8TOARS.
    10.1186/1477-7827-7-133
  35. Åkerfelt, M.; Henriksson, E.; Laiho, A.; Vihervaara, A.; Rautoma, K.; Kotaja, N.; Sistonen, L.. "Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2". Proceedings of the National Academy of Sciences of the United States of America 105 32 (2008): 11224-11229. http://www.scopus.com/inward/record.url?eid=2-s2.0-49649119465&partnerID=MN8TOARS.
    10.1073/pnas.0800620105
  36. Kimmins, S.; Crosio, C.; Kotaja, N.; Hirayama, J.; Monaco, L.; Höög, C.; Van Duin, M.; Gossen, J.A.; Sassone-Corsi, P.. "Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis". Molecular Endocrinology 21 3 (2007): 726-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847194971&partnerID=MN8TOARS.
    10.1210/me.2006-0332
  37. Kotaja, N.; Sassone-Corsi, P.. "The chromatoid body: A germ-cell-specific RNA-processing centre". Nature Reviews Molecular Cell Biology 8 1 (2007): 85-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845784376&partnerID=MN8TOARS.
    10.1038/nrm2081
  38. Kotaja, N.; Lin, H.; Parvinen, M.; Sassone-Corsi, P.. "Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells". Journal of Cell Science 119 13 (2006): 2819-2825. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746923401&partnerID=MN8TOARS.
    10.1242/jcs.03022
  39. Kotaja, N.; Bhattacharyya, S.N.; Jaskiewicz, L.; Kimmins, S.; Parvinen, M.; Filipowicz, W.; Sassone-Corsi, P.. "The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components". Proceedings of the National Academy of Sciences of the United States of America 103 8 (2006): 2647-2652. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644530350&partnerID=MN8TOARS.
    10.1073/pnas.0509333103
  40. Kotaja, N.; Macho, B.; Sassone-Corsi, P.. "Microtubule-independent and protein kinase A-mediated function of kinesin KIF17b controls the intracellular transport of activator of CREM in testis (ACT)". Journal of Biological Chemistry 280 36 (2005): 31739-31745. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744438453&partnerID=MN8TOARS.
    10.1074/jbc.M505971200
  41. Martianov, I.; Brancorsini, S.; Catena, R.; Gansmuller, A.; Kotaja, N.; Parvinen, M.; Sassone-Corsi, P.; Davidson, I.. "Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis". Proceedings of the National Academy of Sciences of the United States of America 102 8 (2005): 2808-2813. http://www.scopus.com/inward/record.url?eid=2-s2.0-14544280215&partnerID=MN8TOARS.
    10.1073/pnas.0406060102
  42. Van Den Akker, E.; Ano, S.; Shih, H.-M.; Wang, L.-C.; Pironin, M.; Palvimo, J.J.; Kotaja, N.; et al. "FLI-1 functionally interacts with PIASxa, a member of the PIAS E3 SUMO ligase family". Journal of Biological Chemistry 280 45 (2005): 38035-38046. http://www.scopus.com/inward/record.url?eid=2-s2.0-27844467195&partnerID=MN8TOARS.
    10.1074/jbc.M502938200
  43. Kotaja, N.; Sassone-Corsi, P.. "Plzf pushes stem cells". Nature Genetics 36 6 (2004): 551-553. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642529268&partnerID=MN8TOARS.
    10.1038/ng0604-551
  44. Kimmins, S.; Kotaja, N.; Fienga, G.; Kolthur, U.S.; Brancorsini, S.; Hogeveen, K.; Monaco, L.; Sassone-Corsi, P.. "A specific programme of gene transcription in male germ cells". Reproductive BioMedicine Online 8 5 (2004): 496-500. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442697679&partnerID=MN8TOARS.
  45. Kotaja, N.; De Cesare, D.; Macho, B.; Monaco, L.; Brancorsini, S.; Goossens, E.; Tournaye, H.; Gansmuller, A.; Sassone-Corsi, P.. "Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene". Proceedings of the National Academy of Sciences of the United States of America 101 29 (2004): 10620-10625. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242671308&partnerID=MN8TOARS.
    10.1073/pnas.0401947101
  46. Kimmins, S.; Kotaja, N.; Davidson, I.; Sassone-Corsi, P.. "Testis-specific transcription mechanisms promoting male germ-cell differentiation". Reproduction 128 1 (2004): 5-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-4043121708&partnerID=MN8TOARS.
  47. Monaco, L.; Kotaja, N.; Fienga, G.; Hogeveen, K.; Kolthur, U.S.; Kimmins, S.; Brancorsini, S.; Macho, B.; Sassone-Corsi, P.. "Specialized rules of gene transcription in male germ cells: The CREM paradigm". International Journal of Andrology 27 6 (2004): 322-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-10844284718&partnerID=MN8TOARS.
    10.1111/j.1365-2605.2004.00494.x
  48. Kotaja, N.; Kimmins, S.; Brancorsini, S.; Hentsch, D.; Vonesch, J.L.; Davidson, I.; Parvinen, M.; Sassone-Corsi, P.. "Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis.". Nat Methods 1 3 (2004): 249-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-11944258521&partnerID=MN8TOARS.
  49. Ungureanu, D.; Vanhatupa, S.; Kotaja, N.; Yang, J.; Aittomäki, S.; Jänne, O.A.; Palvimo, J.J.; Silvennoinen, O.. "PIAS proteins promote SUMO-1 conjugation to STAT1". Blood 102 9 (2003): 3311-3313. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142152429&partnerID=MN8TOARS.
    10.1182/blood-2002-12-3816
  50. Holter, E.; Kotaja, N.; Mäkela, S.; Strauss, L.; Kietz, S.; Jänne, O.A.; Gustafsson, J.-A.; Palvimo, J.J.; Treuter, E.. "Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1". Molecular Endocrinology 16 3 (2002): 515-528. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036192044&partnerID=MN8TOARS.
    10.1210/me.16.3.515
  51. Kotaja, N.; Karvonen, U.; Jänne, O.A.; Palvimo, J.J.. "PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases". Molecular and Cellular Biology 22 14 (2002): 5222-5234. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036291475&partnerID=MN8TOARS.
    10.1128/MCB.22.14.5222-5234.2002
  52. Kotaja, N.; Vihinen, M.; Palvimo, J.J.; Jänne, O.A.. "Androgen receptor-interacting protein 3 and other PIAS proteins cooperate with glucocorticoid receptor-interacting protein 1 in steroid receptor-dependent signaling". Journal of Biological Chemistry 277 20 (2002): 17781-17788. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037124042&partnerID=MN8TOARS.
    10.1074/jbc.M106354200
  53. Kotaja, N.; Karvonen, U.; Jänne, O.A.; Palvimo, J.J.. "The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1.". Journal of Biological Chemistry 277 33 (2002): 30283-30288. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037119457&partnerID=MN8TOARS.
  54. Janne, O.A.; Moilanen, A.-M.; Poukka, H.; Rouleau, N.; Karvonen, U.; Kotaja, N.; Hakli, M.; Palvimo, J.J.. "Androgen-receptor-interacting nuclear proteins". Biochemical Society Transactions 28 4 (2000): 401-405. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033857624&partnerID=MN8TOARS.
  55. Kotaja, N.; Aittomäki, S.; Silvennoinen, O.; Palvimo, J.J.; Jänne, O.A.. "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Molecular Endocrinology 14 12 (2000): 1986-2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034530046&partnerID=MN8TOARS.
    10.1210/me.14.12.1986