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Alexander Trofimov. Published 18 articles in journals. Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences.
Identification

Personal identification

Full name
Alexander Trofimov

Citation names

  • Trofimov, Alexander

Author identifiers

Ciência ID
A419-B837-13E5
ORCID iD
0000-0001-6745-6035

Email addresses

  • alexander.n.trofimov@gmail.com (Professional)

Telephones

Mobile phone
  • (+7) 9523512350 (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Russian (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Projects

Grant

Designation Funders
2016/01 - 2017/12 Molecular and cellular mechanisms of effects of perinatal pathology on the cognitive function development
16-34-00316 mol_a
FGBU Rossijskij centr naucnoj informacii
2016/01 - 2017/12 The role of plasticity and GSK-3b cascades in the mechanisms of depression: a study on mutant mice SERT and TPH2 with genetic deficit of neuronal serotonin
16-34-01165 mol_a
FGBU Rossijskij centr naucnoj informacii
Outputs

Publications

Conference paper
  1. Ksenia Shcherbakova; Alexander Schwarz; Irina Ivleva; Veronika Nikitina; Darya Krytskaya; Sergey Apryatin; Marina Karpenko; Alexander Trofimov. "Acute and Chronic Effects of Medium-Chain Triglyceride Supplementation on Metabolic Parameters and Working Memory in Rats". 2021.
    10.3390/ECB2021-10282
  2. "Early-life LPS administrations induce cognitive decline and changes in NMDA receptor subunit gene expression in the rodent brain". 2014.
    10.1016/j.bbi.2014.06.111
Journal article
  1. S. A. Apryatin; D. S. Traktirov; M. N. Karpenko; I. S. Ivleva; N. S. Pestereva; M. V. Bolshakova; A. N. Trofimov; Z. S. Fesenko; V. M. Klimenko. "Antioxidant system alterations and physiological characteristics of neonatal and juvenile DAT-KO rats". Journal of Neuroscience Research (2023): https://doi.org/10.1002/jnr.25228.
    10.1002/jnr.25228
  2. Ksenia Shcherbakova; Alexander Schwarz; Irina Ivleva; Veronika Nikitina; Darya Krytskaya; Sergey Apryatin; Marina Karpenko; Alexander Trofimov. "Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats". Heliyon (2023): https://doi.org/10.1016/j.heliyon.2023.e13446.
    10.1016/j.heliyon.2023.e13446
  3. Schwarz, Alexander P.; Nikitina, Veronika A.; Krytskaya, Darya U.; Shcherbakova, Ksenia P.; Trofimov, Alexander N.. "Reference gene expression stability within the rat brain under mild intermittent ketosis induced by supplementation with medium-chain triglycerides". Plos One (2023): https://publons.com/wos-op/publon/56520389/.
    10.1371/JOURNAL.PONE.0273224
  4. Trofimov, Alexander; Pavlov, Dmitrii; Goswami, Anand; Gorlova, Anna; Chaprov, Kirill; Umriukhin, Aleksei; Kalueff, Allan; et al. "Lipopolysaccharide triggers exacerbated microglial activation, excessive cytokine release and behavioural disturbances in mice with truncated Fused-in-Sarcoma Protein (FUS)". Brain, Behavior, & Immunity Health (2023): https://publons.com/wos-op/publon/63291227/.
    10.1016/J.BBIH.2023.100686
  5. Alexander Trofimov. "Molecular mechanisms of molecular transfer across the blood-brain barrier as a target for pharmacological action Part 1. Structure, function and pathology of the BBB". Pharmacy Formulas (2022): http://dx.doi.org/10.17816/phf109914.
    10.17816/phf109914
  6. "Supplementation of Regular Diet With Medium-Chain Triglycerides for Procognitive Effects: A Narrative Review". Frontiers in Nutrition 9 (2022): http://dx.doi.org/10.3389/fnut.2022.934497.
    10.3389/fnut.2022.934497
  7. Tatyana Strekalova; Dmitrii Pavlov; Alexander Trofimov; Daniel C. Anthony; Andrei Svistunov; Andrey Proshin; Aleksei Umriukhin; et al. "Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice". International Journal of Molecular Sciences 23 4 (2022): 2061-2061. https://doi.org/10.3390/ijms23042061.
    10.3390/ijms23042061
  8. Nikitina, Veronika; Trofimov, Alexander; Krytskaya, Darya; Schwarz, Alexander; Veniaminova, Ekaterina; Shavva, Vladimir; Ivleva, Irina; et al. "Supplementation with medium-chain triglycerides (MCT) improves memory and alters glutamatergic gene expression in the rat brain". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/54117501/.
  9. Schwarz, Alexander; Zakharova, Maria; Kovalenko, Anna; Dyomina, Alexandra; Trofimov, Alexander; Malygina, Daria; Zubareva, Olga; Zaitsev, Aleksey. "Reference gene stability within the rat brain in the lithium pilocarpine epilepsy model: Timing and region specificity". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/54117502/.
  10. Trofimov, Alexander; Schwarz, Alexander; Ivleva, Irina; Nikitina, Veronika; Krytskaya, Darya; Apryatin, Sergey; Karpenko, Marina; Shcherbakova, Ksenia. "Intermittent ketosis induced by MCT supplement: Dose-dependent differential effects on cognitive and metabolic parameters in rats". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/54117503/.
  11. "Neonatal Exposure to Bacterial Lipopolysaccharide Affects Behavior and Expression of Ionotropic Glutamate Receptors in the Hippocampus of Adult Rats after Psychogenic Trauma". Biochemistry (Moscow) 86 6 (2021): 761-772. http://dx.doi.org/10.1134/s0006297921060134.
    10.1134/s0006297921060134
  12. "Changes in Behavior and the Expression of Ionotropic Glutamate Receptor Genes in the Brains of Adult Rats after Neonatal Administration of Bacterial Lipopolysaccharide". Neuroscience and Behavioral Physiology 50 9 (2020): 1239-1248. http://dx.doi.org/10.1007/s11055-020-01025-7.
    10.1007/s11055-020-01025-7
  13. "Multiplex qPCR assay for assessment of reference gene expression stability in rat tissues/samples.". Molecular and cellular probes (2020): https://doi.org/10.1016/j.mcp.2020.101611.
    10.1016/j.mcp.2020.101611
  14. "¿¿¿¿¿¿¿¿¿ ¿¿¿¿¿¿¿¿¿ ¿ ¿¿¿¿¿¿¿¿¿¿ ¿¿¿¿¿ ¿¿¿¿¿¿¿¿¿¿¿ ¿¿¿¿¿¿¿¿¿¿ ¿¿¿¿¿¿¿¿¿ ¿ ¿¿¿¿¿ ¿¿¿¿¿¿¿¿ ¿¿¿¿ ¿¿¿¿¿ ¿¿¿¿¿¿¿¿¿¿¿¿ ¿¿¿¿¿¿¿¿ ¿¿¿¿¿¿¿¿¿¿¿¿¿¿ ¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿". ¿¿¿¿¿¿¿¿¿¿ ¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿ ¿¿¿¿¿¿ ¿¿  ¿  ¿  ¿¿¿¿¿¿¿¿ 106 3 (2020): 356-372. http://dx.doi.org/10.31857/s0869813920030097.
    10.31857/s0869813920030097
  15. Trofimov, A.; Schwarz, A.; Krytskaya, D.; Shavva, V.; Veniaminova, E.; Sizoff, V.; Shcherbakova, A.. "Mild ketogenic diet as promising approach for cognition enhancement: medium-chain triglyceride supplement improves memory in rats". Journal of Neurochemistry (2019): https://publons.com/wos-op/publon/28171224/.
  16. Alexander P. Schwarz; Alexander Yu. Rotov; Olga I. Chuprina; Darya U. Krytskaya; Alexander N. Trofimov; Vera V. Kosheverova; Alexander M. Ischenko; Olga E. Zubareva. "Developmental prefrontal mRNA expression of D2 dopamine receptor splice variants and working memory impairments in rats after early life Interleukin-1ß elevation". Neurobiology of Learning and Memory 155 (2018): 231-238. https://doi.org/10.1016/j.nlm.2018.08.008.
    10.1016/j.nlm.2018.08.008
  17. Shavva, V.S.; Bogomolova, A.M.; Efremov, A.M.; Trofimov, A.N.; Nikitin, A.A.; Babina, A.V.; Nekrasova, E.V.; et al. "Insulin downregulates C3 gene expression in human HepG2 cells through activation of PPAR¿". European Journal of Cell Biology 97 3 (2018): 204-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043508015&partnerID=MN8TOARS.
    10.1016/j.ejcb.2018.03.001
  18. Strekalova, T.; Bahzenova, N.; Trofimov, A.; Schmitt-Böhrer, A.G.; Markova, N.; Grigoriev, V.; Zamoyski, V.; et al. "Pro-neurogenic, memory-enhancing and anti-stress effects of DF302, a novel fluorine gamma-carboline derivative with multi-target mechanism of action". Molecular Neurobiology 55 1 (2018): 335-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028583544&partnerID=MN8TOARS.
    10.1007/s12035-017-0745-6
  19. Trofimov A; Strekalova T; Mortimer N; Zubareva O; Schwarz A; Svirin E; Umriukhin A; et al. "Postnatal LPS Challenge Impacts Escape Learning and Expression of Plasticity Factors Mmp9 and Timp1 in Rats: Effects of Repeated Training.". (2017): http://europepmc.org/abstract/med/28421528.
    10.1007/s12640-017-9720-2
  20. Schwarz, A.P.; Trofimov, A.N.; Zubareva, O.E.; Lioudyno, V.I.; Kosheverova, V.V.; Ischenko, A.M.; Klimenko, V.M.. "Prefrontal mRNA expression of long and short isoforms of D2 dopamine receptor: Possible role in delayed learning deficit caused by early life interleukin-1ß treatment". Behavioural Brain Research 333 (2017): 118-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021798680&partnerID=MN8TOARS.
    10.1016/j.bbr.2017.06.052
  21. Schwarz, A.; Trofimov, A.; Veniaminova, E.; Zubareva, O.. "Neonatal proinflammatory treatment affects the cognitive functions development and brain neuroplasticity-related gene expression". Journal of Neurochemistry (2017): https://publons.com/wos-op/publon/17824063/.
  22. "Expression of the FGF2 and TIMP1 Genes in the Adult Rat Brain after Administration of Interleukin-1ß during Early Postnatal Ontogeny". Neuroscience and Behavioral Physiology (2016): https://link.springer.com/article/10.1007/s11055-016-0252-7.
    10.1007/s11055-016-0252-7
  23. Couch Y; Trofimov A; Markova N; Nikolenko V; Steinbusch HW; Chekhonin V; Schroeter C; et al. "Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice.". (2016): http://europepmc.org/abstract/med/27184538.
    10.1186/s12974-016-0572-0
  24. Trofimov AN; Zubareva OE; Shvarts AP; Ishchenko AM; Klimenko VM. "[The administration of interleukin-1beta during early postnatal develop ment impairs FGF2, but not TIMP1, mRNA expression in brain structures of adult rats].". (2014): http://europepmc.org/abstract/med/25697011.
  25. "Effects of Neonatal Increases in Interleukin-1beta Levels on the Formation of Spatial Memory in Adult Rats". Neuroscience and Behavioral Physiology (2014): http://link.springer.com/article/10.1007%2Fs11055-014-9918-1.
    10.1007/s11055-014-9918-1
  26. Trofimov, A.N.; Zubareva, O.E.; Shvarts, A.P.; Ishchenko, A.M.; Klimenko, V.M.. "[The administration of interleukin-1beta during early postnatal develop ment impairs FGF2, but not TIMP1, mRNA expression in brain structures of adult rats]". Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk 100 9 (2014): 1025-1037. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925283859&partnerID=MN8TOARS.
  27. Trofimov AN; Zubareva OE; Simbirtsev AS; Klimenko VM. "[The influence of neonatal interleukin-1beta increase on the formation of adult rats' spatial memory].". (2012): http://europepmc.org/abstract/med/23013016.
  28. Trofimov, A.N.; Zubareva, O.E.; Simbirtsev, A.S.; Klimenko, V.M.. "[The influence of neonatal interleukin-1beta increase on the formation of adult rats' spatial memory].". Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk 98 6 (2012): 782-792. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867165130&partnerID=MN8TOARS.