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Rute Alexandra Carvalho Antunes Marcelino, concluiu o Doutoramento em Genética Humana e Doenças Infecciosas em 25/01/2022 pela Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, o Mestrado em Epidemiologia em 2003/02/12 pela Universidade Nova de Lisboa Faculdade de Ciências Médicas e a Licenciatura em Biologia Microbiana e Genética em 1997/11/24 pela Universidade de Lisboa Faculdade de Ciências. É Bolseira de Investigação no(a) Egas Moniz Cooperativa de Ensino Superior CRL. Publicou 7 artigos em revistas especializadas. Organizou 1 evento(s). Recebeu 2 prémio(s) e/ou homenagens. Participa e/ou participou como Bolseiro de Investigação em 2 projeto(s). Trabalha na área da virologia, biologia molecular e evolução viral. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Infecções Respiratórias; Gripe; Laboratory Network; A(H1)pdm09 Diagnosis; Hepatitis C virus; Hepatitis B virus; Phylogenetic Analyses; Direct-acting antivirals; Resistance-associated substitutions; NS5A; NS5B; Infectious Diseases; Health Sciences - HIV/AIDS; .
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Identification

Personal identification

Full name
Rute Alexandra Carvalho Antunes Marcelino

Citation names

  • Marcelino, Rute
  • Rute Antunes, Marcelino R, Antunes R, Rute Marcelino, R.A.C. Marcelino

Author identifiers

Ciência ID
A417-7162-733D
ORCID iD
0000-0002-4535-9725

Email addresses

  • rutemarcelino@ff.ulisboa.pt (Professional)

Telephones

Telephone
  • 217946400 Ext.: 262 (Professional)

Addresses

  • Av Oceano 1 2 Esq., 2825-482, STº António Caparica, Almada, Portugal (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
French Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2015/12/01 - 2022/01/25
Concluded
 Genética Humana e Doenças Infecciosas (Doutoramento)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
"História Evolutiva e Filogeografia dos Vírus da Hepatite C e B em Portugal" (THESIS/DISSERTATION)
 Aprovado
1999/10/01 - 2003/02/12
Concluded
 Epidemiologia (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Muito bom
1992/09/01 - 1997/11/24
Concluded
 Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 15
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2004 - 2011 Visiting Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2001/09 - 2003/03 Trainee Assistant (University Teacher) Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
Egas Moniz Cooperativa de Ensino Superior CRL, Portugal

Positions / Appointments

Category
Host institution 		Employer
2004/05/01 - 2012/07/12 Coordenadora da Unidade de Doenças Infecciosas GenoMed - Diagnósticos de Medicina Molecular, SA, Portugal
GenoMed - Diagnósticos de Medicina Molecular, SA, Portugal

Others

Category
Host institution 		Employer
2019/12/01 - Current Bolseira de Investigação Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2015/12/01 - 2019/11/30 Estudante de Doutoramento Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/05/01 - 2015/11/30 Bolseira de Investigação Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
1997/12/01 - 2004/04/30 Técnica de Laboratório na Unidade de Retrovírus e Infeções Associadas Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2015/12 - 2019/12 Células B de memória: uma nova abordagem na identificação de potenciais domínios neutralizantes envolvidos na eliminação do vírus da Hepatite C (VHC)
SFRH/BD/99507/2014
 Fundação para a Ciência e Tecnologia

Contract

Designation Funders
2019/12/01 - Current Neonatal HIV early infant diagnosis (EID) versus standard-of-care EID – Impact on infant health: a feasibility study of point-of-care testing at birth versus at 6 weeks of age on the uptake of ART and infant prophylaxis, and on rate of infant survival, morbidity and retention in care
RIA2016MC-165
Research Fellow
Ongoing
2014/05/01 - 2015/11/30 A combination of two gp41 peptides for a new prophylactic vaccine both neutralizing HIV-1 and inhibiting CD4 depletion
HIVERA/0001/2013
Research Fellow
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2014 - 2014 Hepatitis C Virus Antiviral Resistance to Simeprevir
Não aplicável
Technical development
Janssen-Cilag Farmacêutica Lda, Portugal
 Janssen-Cilag Farmacêutica Lda
Concluded
Outputs

Publications

Conference abstract
  1. Marcelino, Rute; Janeiro, André; Teresa Porta Nova. "Hepatitis B virus (HBV) Resistant Mutant to Nucleoside Analogues Detection Methods: Certainties and Problems". Paper presented in Reunião Monotemática sobre Hepatites Víricas - Sociedade Portuguesa de Gastroenterologia, Guimarães, 2009.
    Published • 10.1063/1.4991238
  2. Marcelino, Rute; Gomes, Perpétua; Taveira, Nuno; Maria Helena Lourenço; Antunes F. "A Competitive RT-PCR Method For The Quantification Of HIV-2 Viral Load in Plasma". Paper presented in 12th World AIDS Conference, Geneva, 1998.
    Published
Conference paper
  1. "Characterization of NS3 region and frequency of resistance mutations against Simeprevir of Hepatites C virus genotype 1a and 1b in portuguese infected patients". 2016.
    https://doi.org/10.1016/j.jcv.2016.08.136
  2. Pechirra, Pedro; Gonçalves, Paulo; Conde, Patrícia; Guiomar, Raquel; Duque, Vítor; Vaz, João; Ribeiro, Graça; et al. "Characterisation of respiratory disease during the 2010/2011 influenza winter season in Portugal: Contribute of the Laboratory Network for the Diagnosis of Influenza A(H1N1)2009 Infection". 2011.
Conference poster
  1. Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Verónica; Pimentel, Victor; et al. "Epidemiological History of Hepatitis B Virus in Portugal and the Portuguese Role in Its Spreading Across the World". Paper presented in International AIDS Society Conference (IAS), 2021.
Journal article
  1. "Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodomain contributes to reduce viral burden in HIV-1 infected patients". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-88274-9.
    10.1038/s41598-021-88274-9
  2. Palladino, Claudia; Ezeonwumelu, Ifeanyi Jude; Marcelino, Rute; Briz, Verónica; Moranguinho, Inês; Serejo, Fátima; Velosa, José Fernando; et al. "Epidemic history of hepatitis C virus genotypes and subtypes in Portugal". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-30528-0.
    Published • 10.1038/s41598-018-30528-0
  3. Brandão, Ruben; Marcelino, Rute; Gonçalves, Fátima; Diogo, Isabel; Carvalho, Ana; Cabanas, Joaquim; Costa, Inês; et al. "Characterization of NS5A and NS5B resistance-associated substitutions from genotype 1 Hepatitis C Virus infected patients in a Portuguese cohort". (2018): http://hdl.handle.net/10400.26/30657.
    10.3390/v10050223
  4. Portuguese Laboratory Network for the Diagnosis of Influenza Infection. "Contribution of the Portuguese Laboratory Network for the Diagnosis of Influenza A(H1N1)pdm09 infection during the 2009/10 and 2010/11 influenza seasons.". Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin (2012): http://europepmc.org/abstract/med/22790607.
  5. Bartolo, Ines; Rocha, Cheila; Bartolomeu, Jose; Gama, Antonio; Marcelino, Rute; Fonseca, Marlene; Mendes, Ana; et al. "Highly divergent subtypes and new recombinant forms prevail in the HIV/AIDS epidemic in Angola". Infection, Genetics and Evolution 9 4 (2009): 672-682. http://hdl.handle.net/10451/21661.
    http://dx.doi.org/10.1016/j.meegid.2008.05.003
  6. Constantino, A.F.M.; Proenca, M.H.; Rodrigues, T.S.; Marcelino, R.A.C.; Moura, C.M.. "P.135 Epidemiology of HBV infection in Luanda (Angola) — preliminary results". Journal of Clinical Virology 36 (2006): S102. http://dx.doi.org/10.1016/s1386-6532(06)80315-x.
    Published • 10.1016/s1386-6532(06)80315-x
  7. Antunes, R.; Figueiredo, S.; Bartolo, I.; Pinheiro, M.; Rosado, L.; Soares, I.; Lourenco, H.; Taveira, N.. "Evaluation of the Clinical Sensitivities of Three Viral Load Assays with Plasma Samples from a Pediatric Population Predominantly Infected with Human Immunodeficiency Virus Type 1 Subtype G and BG Recombinant Forms". Journal of Clinical Microbiology 41 7 (2003): 3361-3367. http://dx.doi.org/10.1128/jcm.41.7.3361-3367.2003.
    Published • 10.1128/jcm.41.7.3361-3367.2003
  8. Marcelino, Rute; Paediatric European Network for Treatment of AIDS (PENTA).. "Comparison of dual nucleoside-analogue reverse-transcriptase inhibitor regimens with and without nelfinavir in children with HIV-1 who have not previously been treated: the PENTA 5 randomised trial". The Lancet 359 9308 (2002): 733-740. http://dx.doi.org/10.1016/s0140-6736(02)07874-1.
    10.1016/s0140-6736(02)07874-1
  9. Pillay, D.; Walker, A.S.; Gibb, D.M.; De Rossi, A.; Kaye, S.; Ait-Khaled, M.; Muñoz-Fernandez, M.; et al. "Impact of human immunodeficiency virus type 1 subtypes on virologic response and emergence of drug resistance among children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 trial". Journal of Infectious Diseases 186 5 (2002): 617-625. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036721511&partnerID=MN8TOARS.
    10.1086/342680
  10. Soriano V; Gomes P; Heneine W; Holguín A; Doruana M; Antunes R; Mansinho K; et al. "Human immunodeficiency virus type 2 (HIV-2) in Portugal: clinical spectrum, circulating subtypes, virus isolation, and plasma viral load.". Journal of medical virology (2000): http://europepmc.org/abstract/med/10745242.
    10.1002/(sici)1096-9071(200005)61:1<111::aid-jmv18>3.3.co;2-n
Magazine article
  1. Marcelino, Rute. "Como lidar com as resistências virais?", Farmácia Portuguesa, 2009
Newsletter article
  1. Marcelino, Rute. "A genotipagem do vírus do papiloma humano (VPH) está a tornar-se gradualmente relevante na prática clínica", Alumni Fórum, Série II, 2011
Website
  1. Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Verónica; Marinho, Rui Tato; et al. Corresponding author: Marcelino, Rute. Phylogeography of hepatitis B: The role of Portugal in the dissemination of HBV worldwide.. 2022. https://doi.org/10.1101/2022.01.05.22268725.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/12/12 Epidemiological History and Susceptibility of Hepatitis C virus to Antivirals in Portugal X Jornadas Ciêntificas
Instituto de Higiene e Medicina Tropical de Lisboa (Lisboa, Portugal)
2011/11/12 HCV Resistance Sharing Evolution II – Delivering the Commitment
Merk Sharp & Dome (Cascais, Portugal)
2011/10 IL28B Genetic Polimorphisms: portuguese data Advanced Course On Viral Hepatitis
Hospital Santa Maria (Lisboa, Portugal)
2010 Hepatitis B and Occult infection: Concepts, problems and diagnosis; Viral DNA quantification III Congresso Português de Hepatologia
Sociedade Portuguesa de Hepatologia (Évora, Portugal)
2009/01/24 Methods for mutant Hepatitis B viruses, resistant to nucleoside analogs: Certainties and Problems Reunião Monotemática sobre Hepatites Víricas
Sociedade Portuguesa de Gastroenterologia (Guimarães, Portugal)
2009 Serologic Diagnosis of Hepatitis seminar for the 3rd year of Medicine’s Faculty of University of Lisbon
Universidade de Lisboa Faculdade de Medicina (Lisboa)
2008/04/04 Genetic Diversity of Hepatitis B virus (HBV) and Resistance Mutations in Portugal 11th Meeting of Portuguese Association for the Study of the Liver (APEF)
Associação Portuguesa para o Estudo do Fígado (APEF) (Cascais, Portugal)
2004/10/28 Disponibilização de técnicas de diagnóstico molecular para os vírus da Hepatite B e C. Sessão Médica
Clínica Pediátrica do Hospital Santa Maria, Lisbon, Portugal (Lisboa, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015/07/10 - 2015/07/10 The Global Health and Tropical Medicine Meeting: HIV Challenges (2015/07/10 - 2015/07/10)
Conference (Member of the Scientific Committee)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/07/18 - 2021/07/21 e-Poster presentation: "Epidemiological History of Hepatitis B Virus in Portugal and the Portuguese Role in Its Spreading Across the World"
Conference
 International AIDS Society Conference (IAS)
International AIDS Society, Switzerland
2019/12/12 - 2019/12/12 Poster presentation: "Epidemic history of hepatitis B virus genotypes in Portugal"
Symposium
 10th Scientific Meeting of IHMT
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2018/07/02 - 2018/07/04 Digital Poster presentation: "Epidemiological History and Susceptibility to hepatitis C virus antivirals in Portugal"
Meeting
 Encontro Ciência
Fundação para a Ciência e a Tecnologia, Portugal

Ciência Viva, Portugal
2015/04 - 2017/04 Demonstration of method of DNA extraction method in the Open Day of Hygiene and Tropical Medicine Institute of Lisbon in April of 2015, 2016 and 2017.
Other
 Open Day
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/09/14 - 2016/09/17 Poster presentation: "Characterization of NS3 region and frequency of resistance mutations against Simeprevir of Hepatites C virus genotype 1a and 1b in Portuguese infected patients"
Conference
 19th Annual Meeting of the European Society for Clinical Virology
European Society for Clinical Virology, Spain
Distinctions

Award

2009 ROCHE/APEF Project Scholarship
Associação Portuguesa para o Estudo do Fígado (APEF), Portugal
2008 Prémio pela Melhor Apresentação Oral
Associação Portuguesa para o Estudo do Fígado (APEF), Portugal