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Nuno Filipe Lavos Lopes, PhD Student at iBET & ITQB Works in Biomedical and Health Sciences, Health-Related Biotechnology - Keywords: Tumor Microenvironment; Tumor Associated Macrophages; Immune Crosstalk; Breast Cancer; 3D Cell Models; Glycan-lectin interactions Scientific activity - PhD Student, iBET-ITQB (01/2021 - Present) - Junior Research Fellow, iBET & ITQB (01/2020 - 12/2020) - Junior Research Fellow, iBET & ITQB (01/2019 - 12/2019) - MSc Student, iBET & ITQB (09/2017 - 11/2018) Participation in funded projects - CRUZIVAX; Grant: 815418 (European Commission (Brussels)) - Targeting monocytes as angiogenesis promoters in cancer-New application for old drugs; (iNOVA4Health-Project-35) - CardioContract; Grant: 12529/19/Q (EUROSTARS-2) Education - PhD in Molecular Biosciences (2021 - Present), ITQB - MSc in Biotechnology (2018), FCT-NOVA - Post-graduation in Glycochemistry and Glycobiology (2018), FCM-NOVA, FCT-NOVA & FCUL - Bachelor in Cellular and Molecular Biology (2016), FCT-NOVA Outputs Oral communications -"Exploiting 3D Co-culture Models to Depict the Phenotype of Tumor Associated Macrophages in Breast Cancer", at 8th International Conference On Tumor Microenvironment: Progression, Therapy & Prevention - 2018, Portugal Journal articles - "Exploiting 3D cell models to recapitulate macrophage modulation in the breast cancer microenvironment", manuscript in submission (First author) - "Cracking the Breast Cancer Glyco-Code through Glycan-Lectin Interactions: Targeting Immunosuppressive Macrophages"; Int. J. Mol. Sci., 22; 2021 (First author) - "Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis."; Cells, 9(1), 107; 2020 (Co-author) Book chapter - "3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment" (Springer Protocols) - 2020 (Co-author) Conference posters - "Exploiting 3D cell models to depict macrophage-breast cancer crosstalk", at Keynote Symposia on Myeloid Cells and Innate Immunity in Solid Tumors (First author) - "Exploiting 3D cell models to study macrophage modulation in the breast cancer microenvironment", at EACR-AACR-ASPIC Conference: Tumor Microenvironment - 2020, Portugal (First author) - "Exploring NK cell engagement in 3D cell models of HER2+ breast cancer microenvironment", at EACR-AACR-ASPIC Conference: Tumor Microenvironment - 2020, Portugal (Co-author) - "A 3D cell model of tumor microenvironment to explore tumor ¿ endothelial cell interaction", at EACR-AACR-ASPIC Conference: Tumor Microenvironment - 2020, Portugal (Co-author) - "A 3D cell model to depict macrophage modulation in breast cancer microenvironment", at 3rd Symposium on Immunomodulation in Cancer and Regeneration: T-Cells and Immunotherapies - 2019, Portugal (First author) - "Exploiting 3D cell-based models to recapitulate Breast Cancer-Macrophage crosstalk", at Defence is the Best Attack: Immuno-Oncology Breakthroughs - 2019, Spain (First author) Thesis MSc thesis: "Depicting the Tumor Associated Macrophage phenotype employing 3D Breast Cancer Cell Models" - 2018, Portugal. Concluded with 19/20 values. Event participations Internships - Functional Glycobiology Lab, FCT-NOVA - Dr Angelina Palma (02/2020- 03/2020) - Tumor Microenvironment Lab, i3S - Dr Maria José Oliveira (03/2019) Conferences - Keynote Symposia on Myeloid Cells and Innate Immunity in Solid Tumors - 2020 - EACR-AACR-ASPIC Conference: Tumor Microenvironment - 2020, Portugal - 3rd Symposium on Immunomodulation in Cancer and Regeneration: T-Cells and Immunotherapies - 2019, Portugal - Defence is the Best Attack: Immuno-Oncology Breakthroughs - 2019, Spain - 8th International Conference On Tumor Microenvironment: Progression, Therapy & Prevention - 2018, Portugal Workshops - Introduction to Glycomic and Glycoproteomic analysis - 2020 - 2nd FLxFlow - Principles and Applications of Flow Cytometry - 2018, Portugal
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Identification

Personal identification

Full name
Nuno Filipe Lavos Lopes

Citation names

  • Lopes, Nuno

Author identifiers

Ciência ID
A217-25D0-E92D
ORCID iD
0000-0003-2300-9107

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/01/01 - 2024/12
Ongoing
 Molecular Biosciences (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"GLYCO-Interact: defining triple negative breast cancer glycan signatures to target tumour-associated macrophages" (THESIS/DISSERTATION)
2018/03 - 2018/11
Concluded
 Glycobiology & Glycochemistry: International E-Learning Course - 4th Edition (Pós-Graduação)
Major in Glycosciences
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
18
2016/09 - 2018/11
Concluded
 Biotecnologia (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Depicting the tumor-associated macrophage phenotype employing 3D breast cancer cell models" (THESIS/DISSERTATION)
 17,4
2013/09 - 2016/07
Concluded
 Biologia Celular e Molecular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2021/01/01 - Current Researcher (Research) iNOVA4Health, Portugal
Instituto de Biologia Experimental e Tecnológica, Portugal
2018/12 - 2020/12/31 Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
Instituto de Biologia Experimental e Tecnológica, Portugal
(...)
2017/09 - 2018/11 Research Trainee (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
Instituto de Biologia Experimental e Tecnológica, Portugal
(...)
Projects

Grant

Designation Funders
2021/11/01 - Current Glyco-TAM: Cracking glycan-lectin interactions to target immunosuppressive macrophages in triple-negative breast cancer
PTDC/BTM-ORG/0971/2020
PhD Student Fellow
iNOVA4Health, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2024/12/31 GLYCO-Interact: defining triple negative breast cancer glycan signatures to target tumour-associated macrophages
2020.07623.BD
10.54499/2020.07623.BD
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01 - 2020/12 CRUZIVAX
815418
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
European Commission
Ongoing
2019/01 - 2019/12 CARDIOCONTRACT: Automated Cardiomyocyte Contractility Assay Instrument
12529/19/Q
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Eurostars
Ongoing
2018/09 - 2018/12 Targeting monocytes as angiogenesis promoters in cancer- New application for old drugs
Project-35
Integration into Research Grant Fellow
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
 iNOVA4Health
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Rebelo, Sofia P.; Pinto, Catarina; Lopes, Nuno; Martins, Tatiana R.; Alves, Paula Marques; Brito, Catarina. "3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment". In Methods in Pharmacology and Toxicology, 117-130. Springer US, 2020.
    Published • 10.1007/978-1-0716-0171-6_8
Conference abstract
  1. Domenici, Giacomo; Trindade, Gonçalo; Lopes, Nuno; Ana L cartaxo; J Minet Minard; Catarina Brito. "A platform of reconstructed 3D cell models of the Tumor Microenvironment to address antibody-based therapies". Paper presented in Dechema 3D Cell Culture 2023: Models, Applications and Translation, Freiburg, 2023.
  2. Lopes, Nuno; Trindade, Gonçalo; Correia, Viviana G.; Benedita Pinheiro; Palma, Angelina S.; Catarina Brito. "Profiling glycan epitopes in Triple Negative Breast Cancer to explore interactions with tumour-associated macrophages". Paper presented in 14th International Meeting of the Portuguese Carbohydrate Group - GLUPOR 14, Caparica, 2023.
Conference poster
  1. Lopes, Nuno; Correia, Viviana G.; Trindade, Gonçalo; Domenici, Giacomo; Palma, Angelina S.; Catarina Brito. "Screening the triple negative breast cancer cell glycome to target immunosuppression mediated by tumour-associated macrophages". Paper presented in III ASPIC-ASEICA International Meeting: Cancer Immunology, Tumor Microenvironment & Metastasis, 2023.
  2. Domenici, Giacomo; Trindade, Gonçalo; Lopes, Nuno; Joan Miret Minard; Catarina Brito. "3D models of immunosuppressive breast tumor microenvironment to evaluate novel antibody-based therapies". Paper presented in III ASPIC-ASEICA International Meeting: Cancer Immunology, Tumor Microenvironment & Metastasis, 2023.
  3. Lopes, Nuno; Cartaxo, Ana L; Batalha, Ana Sofia; Pinto, Catarina; Domenici, Giacomo; Rebelo, Sofia; Oliveira, Maria José; Brito, Catarina. "Exploiting 3D cell models to depict macrophage-breast cancer crosstalk". Paper presented in Keynote Symposia on Myeloid Cells and Innate Immunity in Solid Tumors, 2020.
  4. Lopes, Nuno; Cartaxo, Ana; Pinto, Catarina; Domenici, Giacomo; Rebelo, Sofia P.; Oliveira, Maria José; Catarina Brito. "Exploiting 3D cell models to depict macrophage-breast cancer crosstalk". Paper presented in Keynote Symposia on Myeloid Cells and Innate Immunity in Solid Tumors, 2020.
  5. Franchi Mendes, Teresa; Lopes, Nuno; Brito, Catarina. "A 3D cell model of tumor microenvironment to explore tumor – endothelial cell interaction". Paper presented in EACR-AACR-ASPIC: Tumor Microenvironment, 2020.
  6. Batalha, Sofia; Domenici, Giacomo; Lopes, Nuno. "Exploring NK cell engagement in 3D cell models of HER2+ breast cancer microenvironment". Paper presented in EACR-AACR-ASPIC: Tumor Microenvironment, 2020.
  7. Lopes, Nuno; Cartaxo, Ana; Pinto, Catarina; Domenici, Giacomo; Rebelo, Sofia; Oliveira, Maria José; Brito, Catarina. "A 3D cell model to depict macrophage modulation in breast cancer microenvironment". Paper presented in 3rd Symposium of Immunomodulation in Cancer and Regeneration - Tcells and immunotherapies, 2019.
  8. Lopes, Nuno; Cartaxo, Ana; Pinto, Catarina; Domenici, Giacomo; Rebelo, Sofia; Oliveira, Maria José; Brito, Catarina. "Exploiting 3D cell-based models to recapitulate Breast Cancer-Macrophage crosstalk". Paper presented in Defence is the Best Attack: Immuno-Oncology Breakthroughs, 2019.
Journal article
  1. Teresa Franchi-Mendes; Nuno Lopes; Catarina Brito. "Heterotypic Tumor Spheroids in Agitation-Based Cultures: A Scaffold-Free Cell Model That Sustains Long-Term Survival of Endothelial Cells". Frontiers in Bioengineering and Biotechnology 9 (2021): http://dx.doi.org/10.3389/fbioe.2021.649949.
    10.3389/fbioe.2021.649949
  2. Lopes, Nuno; Correia, Viviana G.; Palma, Angelina S.; Brito, Catarina. "Cracking the Breast Cancer Glyco-Code through Glycan-Lectin Interactions: Targeting Immunosuppressive Macrophages". International Journal of Molecular Sciences 22 4 (2021): http://dx.doi.org/10.3390/ijms22041972.
    Published • 10.3390/ijms22041972
  3. Lopes-Coelho, Filipa; Silva, Fernanda; Gouveia-Fernandes, Sofia; Martins, Carmo; Lopes, Nuno; Domingues, Germana; Brito, Catarina; et al. "Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis". Cells 9 1 (2020): 107. http://dx.doi.org/10.3390/cells9010107.
    10.3390/cells9010107
Thesis / Dissertation
  1. Lopes, Nuno Filipe Lavos. "Depicting the Tumor Associated Macrophege phenotype employing 3D Breast Cancer Cell Models". Master, 2018. http://hdl.handle.net/10362/53682.
Working paper
  1. Lopes, Nuno; Cartaxo, Ana; Pinto, Catarina; Domenici, Giacomo; Gualda, Emilio; Loza-Alvarez, Pablo; Rebelo, Sofia; Oliveira, Maria José; Brito, Catarina. 2020. "Exploiting 3D cell models to recapitulate macrophage modulation in the breast cancer microenvironment".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/06 Exploiting 3D Co-culture Models to Depict the Phenotype of Tumor Associated Macrophages in Breast Cancer 8th International Conference On Tumor Microenvironment: Progression, Therapy & Prevention
International Cancer Microenvironment Society (Lisboa, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/01 - 2023/01 14th International Meeting of the Portuguese Carbohydrate Group (GLUPOR 14) (2023/01/16 - 2023/01/18)
Conference (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/09/21 - 2020/09/23 Keynote Symposia on Myeloid Cells and Innate Immunity in Solid Tumors
Conference
 Keynote Symposia on Myeloid Cells and Innate Immunity in Solid Tumors
2020/08/10 - 2020/08/12 Introduction to Glycomic and Glycoproteomic Analysis
Workshop
 Introduction to Glycomic and Glycoproteomic Analysis
University of Georgia Complex Carbohydrate Research Center, United States
2020/03 - 2020/03 EACR-AACR-ASPIC Conference: Tumor Microenvironment
Conference
 EACR-AACR-ASPIC Conference: Tumor Microenvironment
European Association For Cancer Research, United Kingdom
2019/06 - 2019/06 3rd Symposium of Immunomodulation in Cancer and Regeneration - Tcells and immunotherapies
Conference
 3rd Symposium of Immunomodulation in Cancer and Regeneration - Tcells and immunotherapies.
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/03 - 2019/03 Defence is the Best Attack: Immuno-Oncology Breakthroughs
Conference
 Defence is the Best Attack: Immuno-Oncology Breakthroughs
European Association For Cancer Research, United Kingdom
2018/11 - 2018/11 FLxFlow: Training course on flow cytometry, with Hands-on session (Basic and advanced modules).
Workshop
 2nd FLxFlow Course: Principles and Applications of Flow Cytometry
Instituto Gulbenkian de Ciência, Portugal
2018/02 - 2018/02 Jornadas Intercalares de Mestrado
Conference
 Jornadas Intercalares de Mestrado
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal