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Nadia Gonçalves (NG) has concluded her PhD in Cardiovascular Sciences in 2016 by the Faculty of Medicine of University of Porto (FMUP). She has a Master (2008) and Graduation (2006) in Biology both by the Faculty of Sciences of University of Porto. She has integrated the Cardiovascular Research Center (UnIC) in FMUP in 2005 and has been collaborating in basic and clinical research work ever since. NG has an extended experience in animal science by performing cardiovascular surgical and pharmacological models, bi-ventricular hemodynamic procedures and ex-vivo cardiac function evaluation techniques. Due to her work in UnIC, NG has also developed major skills in molecular and cellular biology (mRNA, western blotting, primary cell culture). NG is currently a principal investigator in UnIC where she dedicates her time to research the crosstalk between adipose tissue and cardiovascular function. She also lectures physiology classes and supervises pre- and post-graduated students of FMUP. In her curriculum NG has published 9 scientific papers, has contributed to 9 research projects and has 8 awards/distinctions as author or co-author.
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Identification

Personal identification

Full name
Nádia Gonçalves

Citation names

  • Gonçalves, N

Author identifiers

Ciência ID
A213-5890-03C5
ORCID iD
0000-0002-7169-4711

Email addresses

  • nadian@med.up.pt (Professional)

Telephones

Mobile phone
  • (+351) 916140275 (Personal)
Telephone
  • (351) 220426793 (Professional)

Addresses

  • Universidade do Porto, Faculdade de Medicina, Unidade de Investigação Cardiovascular (UnIC). Al. Prof. Hernâni Monteiro, 4200-319, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Physiology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019/10/18
Concluded
 Comissões de ética e Investigação em saúde - Impacto das alterações na lei e desafios para o futuro (Outros)
Universidade do Porto Faculdade de Medicina, Portugal
2018
Concluded
 All About Clinical Trials (Outros)
ESC - European Society of Cardiology , France
2018
Concluded
 Good Clinical Practice (Outros)
AIDFM-CETERA, Portugal
2018
Concluded
 O novo regulamento europeu de proteção de dados pessoais (Outros)
Universidade do Porto Faculdade de Medicina, Portugal
2018
Concluded
 Biobancos, investigação e saúde pública: promessas e desafios (Outros)
Universidade do Porto Faculdade de Medicina, Portugal
2017
Concluded
 O novo regulamento europeu de proteção de dados e a agenda da área da saúde (Outros)
Universidade do Porto Faculdade de Medicina, Portugal
2016/09/29
Concluded
 Ciências Cardiovasculares (Doutoramento)
Universidade do Porto, Portugal
"Adiposopathy and its link to cardiovascular diseases" (THESIS/DISSERTATION)
2010
Concluded
 Hands-On Proteomics Course 2010 (Outros)
Universidade de Aveiro, Portugal
2010
Concluded
 Proteomics Workshop (Outros)
Universidade de Aveiro, Portugal
2008
Concluded
 Biologia (Mestrado)
Universidade do Porto, Portugal
"Efeito da apelina num modelo murino de hipertensão pulmonar induzida pela monocrotalina" (THESIS/DISSERTATION)
 18
2008
Concluded
 Course on Animal Cell Culture (Outros)
Universidade do Porto, Portugal
2007
Concluded
 Course of Science in Laboratory Animals – Investigator/Coordenator (Cat C) (Outros)
Universidade do Porto, Portugal
2007
Concluded
 Curricular unit: "Heart Failure" from Medicine and Molecular Oncology master degree (Outros)
Universidade do Porto, Portugal
2006
Concluded
 Biologia (Licenciatura)
Universidade do Porto, Portugal
"Implicações da diabetes na resposta à sobrecarga ventricular esquerda e progressão para a insuficiência cardíaca" (THESIS/DISSERTATION)
 14
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2016/09 - 2019/08 Invited Adjunct Teacher (Polytechnic Teacher) Escola Superior de Enfermagem do Porto, Portugal
Escola Superior de Enfermagem do Porto, Portugal
2009/09 - 2016/08 Invited Adjunct Teacher (Polytechnic Teacher) Escola Superior de Enfermagem de Santa Maria, Portugal
Escola Superior de Enfermagem de Santa Maria, Portugal

Others

Category
Host institution 		Employer
2020 - Current Researcher | SexPeRT - Sequencial eletrical pacing for resynchronization therapy PTDC/BTM-SAL/32616/2017 Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2016 - Current LabManager - Department of Surgery and Physiology Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2016 - 2019 Researcher | DOCNET - Diabetes & Obesity at the Crossroads Between Oncological and Cardiovascular Diseases – A System Analysis Network Towards Precision Medicine NORTE-01-0145-FEDER-000003 Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2009 - 2016 PhD student | SFRH/BD/66628/2009 Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2012 - 2012 Research Internship | PhD degree Fundação para a Ciência e a Tecnologia, Portugal
Vrije Universiteit Amsterdam, Netherlands
2006 - 2008 Master student Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2005 - 2006 Research Internship | Biology degree Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
Projects

Contract

Designation Funders
2020 - Current SexPeRT - Sequencial eletrical pacing for resynchronization therapy
PTDC/BTM-SAL/32616/2017
Researcher
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/05/01 - 2020 Metabolic Therapy for Managing Diastolic Heart Failure - MINOTAUR
info:eu-repo/grantAgreement/FWF/Internationale Projekte/I 3301/AT
Researcher
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
 Fonds zur Förderung der wissenschaftlichen Forschung
Ongoing
2016 - 2020 DOCNET - Diabetes & Obesity at the Crossroads Between Oncological and Cardiovascular Diseases – A System Analysis Network Towards Precision Medicine
NORTE-01-0145-FEDER-000003
Researcher
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
2013 - 2015 Diastolic Heart Failure: Unravelling Novel Pathophysiologic Mechanisms as Potential Therapeutic Targets
EXCL/BIM-MEC/0055/2012
Researcher
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 Left Ventricular Reverse Remodelling After Overload Relief: Potential Role of microRNAs as Biomarkers and Therapeutic Targets
PTDC/BIM-MEC/0998/2012
Researcher
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2013 Nutritional modulation of inflammation, oxidative stress and apoptosis associated with cardiac cachexia.
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/116119/PT
Researcher
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
 Fonds zur Förderung der wissenschaftlichen Forschung
Concluded
2010/04/01 - 2013 Mechanisms underlying cardiac protection induced by exercise in a model of acute pressure overload
PTDC/DES/104567/2008
Researcher
Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2007 Impact of diabetes mellitus on myocardium remodeling induced by pressure overload and ischemia
POCTI/SAL-MMO/61547/2004
Researcher
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
Concluded
Outputs

Publications

Journal article
  1. Gonçalves, N. "Fat Quality Matters: Distinct Proteomic Signatures Between Lean and Obese Cardiac Visceral Adipose Tissue Underlie its Differential Myocardial Impact". Cellular Physiology and Biochemistry 54 3 (2020): 384-400. http://dx.doi.org/10.33594/000000226.
    10.33594/000000226
  2. Miranda-Silva, Daniela; Wüst, Rob C. I.; Conceição, Glória; Gonçalves-Rodrigues, Patrícia; Gonçalves, Nádia; Gonçalves, Alexandre; Kuster, Diederik W. D.; et al. "Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction". Acta Physiologica 228 3 (2019): http://dx.doi.org/10.1111/apha.13378.
    10.1111/apha.13378
  3. Gonçalves, N.; Gomes-Ferreira, C.; Moura, C.; Roncon-Albuquerque, R.; Leite-Moreira, A.F.; Falcão-Pires, I.. "Worse cardiac remodeling in response to pressure overload in type 2 diabetes mellitus". International Journal of Cardiology 217 (2016): 195-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968884317&partnerID=MN8TOARS.
    10.1016/j.ijcard.2016.04.178
  4. Gonçalves, N.; Silva, A.F.; Rodrigues, P.G.; Correia, E.; Moura, C.; Eloy, C.; Roncon-Albuquerque, R.; Falcão-Pires, I.; Leite-Moreira, A.F.. "Early cardiac changes induced by a hypercaloric western-type diet in “subclinical” obesity". American Journal of Physiology - Heart and Circulatory Physiology 310 6 (2016): H655-H666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975912829&partnerID=MN8TOARS.
    10.1152/ajpheart.00684.2015
  5. Dias-Neto, M.; Luísa-Neves, A.; Pinho, S.; Gonçalves, N.; Mendes, M.; Eloy, C.; Lopes, J.M.; et al. "Pathophysiology of Infantile Pulmonary Arterial Hypertension Induced by Monocrotaline". Pediatric Cardiology 36 5 (2015): 1000-1013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939946817&partnerID=MN8TOARS.
    10.1007/s00246-015-1111-y
  6. Moreira-Gonçalves, D.; Ferreira, R.; Fonseca, H.; Padrão, A.I.; Moreno, N.; Silva, A.F.; Vasques-Nóvoa, F.; et al. "Cardioprotective effects of early and late aerobic exercise training in experimental pulmonary arterial hypertension". Basic Research in Cardiology 110 6 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84944068074&partnerID=MN8TOARS.
    10.1007/s00395-015-0514-5
  7. Goncalves, N.; Falcaõ-Pires, I.; Leite-Moreira, A.F.. "Adipokines and their receptors: Potential new targets in cardiovascular diseases". Future Medicinal Chemistry 7 2 (2015): 139-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923131513&partnerID=MN8TOARS.
    10.4155/fmc.14.147
  8. Gavina, C.; Falcão-Pires, I.; Rodrigues, J.; Marinho, B.; Gonçalves, N.; Lopes, R.; Amorim, M.J.; et al. "Load independent impairment of reverse remodeling after valve replacement in hypertensive aortic stenosis patients". International Journal of Cardiology 170 3 (2014): 324-330. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890989898&partnerID=MN8TOARS.
    10.1016/j.ijcard.2013.11.006
  9. Pimentel-Nunes P; Gonçalves N; Boal-Carvalho I; Afonso L; Lopes P; Roncon-Albuquerque R Jr; Henrique R; et al. "Helicobacter pylori induces increased expression of Toll-like receptors and decreased Toll-interacting protein in gastric mucosa that persists throughout gastric carcinogenesis.". (2013): http://europepmc.org/abstract/med/23061653.
    10.1111/hel.12008
  10. Pimentel-Nunes P; Teixeira AL; Pereira C; Gomes M; Brandão C; Rodrigues C; Gonçalves N; et al. "Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans.". (2013): http://europepmc.org/abstract/med/22999059.
    10.1016/j.dld.2012.08.006
  11. Soares JB; Pimentel-Nunes P; Afonso L; Rolanda C; Lopes P; Roncon-Albuquerque R Jr; Gonçalves N; et al. "Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence.". Innate Immun. 5 18 (2012): 700-708. http://europepmc.org/abstract/med/22330637.
    Published • 10.1177/1753425912436762
  12. Pimentel-Nunes, Pedro; Gonçalves, Nádia; Boal-Carvalho, Inês; Afonso, Luís; Lopes, Paula; Roncon-Albuquerque, Roberto; Soares, João-Bruno; et al. "Decreased Toll-interacting protein and peroxisome proliferator-activated receptor ¿ are associated with increased expression of Toll-like receptors in colon carcinogenesis". Journal of Clinical Pathology 65 4 (2012): 302-308. http://dx.doi.org/10.1136/jclinpath-2011-200567.
    10.1136/jclinpath-2011-200567
  13. Falcão-Pires I; Palladini G; Gonçalves N; van der Velden J; Moreira-Gonçalves D; Miranda-Silva D; Salinaro F; et al. "Distinct mechanisms for diastolic dysfunction in diabetes mellitus and chronic pressure-overload.". Basic Res Cardiol. 5 106 (2011): 801-814. http://europepmc.org/abstract/med/21533831.
    Published • 10.1007/s00395-011-0184-x
  14. Pimentel-Nunes, P; Afonso, L; Lopes, P; Roncon-Albuquerque R, Jr; Gonçalves, N; Henrique, R; Moreira-Dias, L; et al. "Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia". Pathol Oncol Res. 3 17 (2011): 677-683. http://europepmc.org/abstract/med/21455638.
    Published • 10.1007/s12253-011-9368-9
  15. Falcão-Pires I; Gonçalves N; Gavina C; Pinho S; Teixeira T; Moura C; Amorim MJ; et al. "Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment?". Expert Opin Ther Targets 3 14 (2010): 231-241. http://europepmc.org/abstract/med/20055692.
    Published • 10.1517/14728220903485685
  16. Pimentel-Nunes, P; Gonçalves, N; Roncon-Albuquerque R, Jr; Fernandes-Cerqueira, C; Cardoso, H; Bastos, RP; Marques, M; et al. "Attenuation of toll-like receptor 2-mediated innate immune response in patients with alcoholic chronic liver disease". Liver Int. 7 30 (2010): 1003-1011. http://europepmc.org/abstract/med/20492495.
    Published • 10.1111/j.1478-3231.2010.02251.x
  17. Gonçalves, N.; Roncon-Albuquerque Jr., R.; Oliveira, M.; Quina-Rodrigues, C.; Lourenço, A.P.; Leite-Moreira, A.F.. "A high-calorie diet attenuates cachexia and adipose tissue inflammation in monocrotaline-induced pulmonary hypertensive rats | A dieta hipercalórica atenua a caquexia e a inflamação do tecido adiposo no modelo murino de hipertensáo pulmonar induzida pela monocrotalina". Revista Portuguesa de Cardiologia 29 3 (2010): 391-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954193370&partnerID=MN8TOARS.
  18. Falcão-Pires I; Gonçalves N; Henriques-Coelho T; Moreira-Gonçalves D; Roncon-Albuquerque R Jr; Leite-Moreira AF. "Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension.". (2009): http://europepmc.org/abstract/med/19346461.
    10.1152/ajpheart.00089.2009
  19. Falcão-Pires, I; Gonçalves, N; Moura, C; Lamego, I; Eloy, C; Lopes, JM; Begieneman, MP; et al. "Effects of diabetes mellitus, pressure-overload and their association on myocardial structure and function.". Am J Hypertens 11 22 (2009): 1190-1198.
    Published
Thesis / Dissertation
  1. Gonçalves, N. "Adiposopathy and its link to cardiovascular diseases". PhD, 2016.
  2. Gonçalves, N. "Efeito da apelina num modelo murino de hipertensão pulmonar induzida pela monocrotalina". Master, 2008.
  3. Gonçalves, N. "Implicações da diabetes na resposta à sobrecarga ventricular esquerda e progressão para a insuficiência cardíaca.". Degree, 2006.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017 The actions of elevated BNP on adipose tissue adaptations during chronic pressure overload. 24th European Congress on Obesity (ECO2017)
(Porto, Portugal)
2016 Alterações Cardíacas Desencadeadas por uma Dieta Hipercalórica na Pré-obesidade – Uma Cardiomiopatia Escondida? Congresso Nacional de Diabetes
(Porto, Portugal)
2015 Alterations promoted by epicardial adipokines in cardiac structure Heart Failure Congress 2015
(Sevilha, Spain)
2006 Distinct effects of chronic left ventricular pressure overload in normal and diabetic hearts X workshop of the ESH Young Investigator Initiative Group
(Madrid, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - 2019 Early molecular pulmonary effects in an animal model of chronic left pressure overload
Co-supervisor
 Mestrado Integrado em Medicina (Master)
Universidade do Porto, Portugal
2012 - 2014 Influence of adipokines in cardiac structure
Supervisor
 Mestrado em Fisiopatologia Cardiovascular (Master)
Universidade do Porto, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/03/14 - Current Using the big data retrieved from Omics to understand cardiovascular diseases (2018/03/14)
Workshop (Member of the Organising Committee)
 Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2019 - 2019 Organizing Committee: Congress SPCCTV 4D Visions 2019 - Surgery without borders (2019/11/23 - 2019/11/24)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Cirurgia Cardiotorácica e Vascular, Portugal
2017 - 2018 Organizing Committee: iNoTeS - Novel Therapeutic Strategies for Noncommunicable Diseases (2018/06/22 - 2018/06/23)
Congress (Member of the Organising Committee)
 Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal

Universidade do Porto Unidade Multidisciplinar de Investigação Biomédica, Portugal

Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/05/14 - 2019/05/16 ERA-Net on Cardiovascular Diseases (ERA-CVD) Symposium
Symposium
European Union, Belgium

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2015 - Current Cellular Biology and Histology Master Degree Course in Cardiovascular Pathophisiology (Mestrado) Universidade do Porto, Portugal
2015 - Current Molecular Biology Master Degree Course in Cardiovascular Pathophisiology (Mestrado) Universidade do Porto, Portugal
2015 - Current Mechanisms of cardiac injury Master Degree Course in Cardiovascular Pathophisiology (Mestrado) Universidade do Porto, Portugal
2011 - Current Mechanisms of cardiac injury Doctoral Programm in Cardiovascular Sciences (Doutoramento) Universidade do Porto, Portugal
2011 - Current Molecular and cellular biology I Doctoral Programm in Cardiovascular Sciences
2016 - 2019 Physiology Enfermagem (Licenciatura) Escola Superior de Enfermagem do Porto, Portugal
2009 - 2016 Physiology Enfermagem (Licenciatura) Escola Superior de Enfermagem de Santa Maria, Portugal

Other jury / evaluation

Activity description Institution / Organization
2019/09/12 - 2019/09/15 Jury for the Physiology & Immunology Parallel Oral Session on the Fourteenth YES (Young European Scientist) Meeting Universidade do Porto Faculdade de Medicina, Portugal
Distinctions

Other distinction

2011 Bolsa de Investigação Clínica D. Manuel de Mello 2011
Fundação Amélia de Mello, Portugal
2009 Prémio Servier na Insuficiência Cardíaca - Investigação Básica
Sociedade Portuguesa de Cardiologia, Portugal
2009 Bolsa de Estudo SPEDM/ABBOTT para a Investigação em Obesidade
Sociedade Portuguesa de Cardiologia, Portugal
2008 Prémio para a melhor comunicação de ciência básica
Sociedade Portuguesa de Cardiologia, Portugal
2008 Bolsa de Estudo João Porto
Sociedade Portuguesa de Cardiologia, Portugal
2008 Bolsa de Investigação Roche/Associação Portuguesa para o Estudo do Fígado
Sociedade Portuguesa de Cardiologia, Portugal
2007 Bolsa D. Manuel Mello 2007
2006 Xth Workshop of the ESH Young Investigator Initiative Group Grant
Sociedade Portuguesa de Cardiologia, Portugal