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Identification

Personal identification

Full name
Raphaël Faustino Canadas

Citation names

  • Canadas, Raphaël F.
  • Canadas, R. F.

Author identifiers

Ciência ID
A11C-57BF-DEEE
ORCID iD
0000-0001-9504-4206
Google Scholar ID
Raphaël F. Canadas
Researcher Id
I-3514-2015

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Engineering and Technology - Materials Engineering
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2018/05/15
Concluded
 Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (Doutoramento)
Major in Sem especialidade
Universidade do Minho, Portugal
"Advanced techonological approaches for 3-D hierarchical living tissues" (THESIS/DISSERTATION)
 Aprovado (Muito Bom; Média 18 valores)
2011/11/22
Concluded
 Bioengenharia e Nanossistemas (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Electrospun nanofibers for human stem cell cultivation" (THESIS/DISSERTATION)
 16
2009/09/11
Concluded
 Biologia Celular e Molécular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Seminário final: "Estudos bioquímicos em enzimas envolvidas no metabolismo do ferro oxidativo"" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2019/06/01 - 2020/09/20 Contracted Researcher (Research) Universidade do Minho, Portugal
Biomaterials Biodegradables and Biomimetics, Portugal

Others

Category
Host institution 		Employer
2018/06/17 - 2019/05/31 Postdoc Fellow under the scope of SCIENTIFIC AND TECHNOLOGICAL CO-OPERATION BETWEEN FCT AND MOST (JICAM), FCT/4773/4/5/2017/S 3BIOMED Universidade do Minho, Portugal
Biomaterials Biodegradables and Biomimetics, Portugal
2018/12/02 - 2019/01/27 Visiting Researcher University College London Research Department of Materials and Tissue, United Kingdom
Royal National Orthopaedic Hospital Stanmore, United Kingdom
2014/04/01 - 2018/05/15 PhD student supported by FCT with Fellowship SFRH/BD/92565/2013, “Novel Osteochondral 3D model as an in vitro technological platform for drugs screening: understanding the molecular and cellular chang Fundação para a Ciência e a Tecnologia, Portugal
2016/04/04 - 2017/04/03 Visiting Researcher Stanford University School of Medicine, United States
Stanford University, United States
2014/01/01 - 2014/03/31 Research Fellowship - Fundo Europeu de Desenvolvimento Regional (FEDER) project 0687_NOVOMAR_1_P named "NOVOMAR - Consolidation of Multipolar Center for the Enhancement of Marine Resources aiming use Universidade do Minho, Portugal
2012/03/01 - 2013/12/31 Bolsa de Investigação para Mestre no âmbito do Projecto PTDC/CTMBPC/115977/2009, designado "OsteoCart- A bilayered hybrid structure for osteochondral regeneration" Universidade do Minho, Portugal
2008/10/24 - 2009/10/23 Bolsa de Integração na Investigação - "Estudos bioquímicos em enzimas envolvidas no metabolismo do ferro oxidativo" Universidade Nova de Lisboa, Portugal
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2006/07/03 - 2006/07/14 Estágio Ocupação Científica de Jovens nas Férias, Agência Ciência Viva - "Plantas transgénicas: como se fazem e para quê?" Ciência Viva, Portugal
Outputs

Publications

Book chapter
  1. Fernandes, Diogo C.; Canadas, Raphaël F.; Reis, Rui L.; Oliveira, Joaquim Miguel; Canadas, Raphael F.; Reis, Rui L.; Oliveira, Joaquim M.. "Dynamic culture systems and 3D interfaces models for cancer drugs testing". In Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models, edited by Oliveira, Joaquim Miguel; Reis, Rui L.. Springer, 2020.
    In press • http://dx.doi.org/10.1007/978-3-030-36588-2_9
  2. Canadas, Raphaël F.; Pirraco, Rogério P.; Oliveira, J. Miguel; Reis, Rui L.; Marques, Alexandra P.. "Stem Cells for Osteochondral Regeneration". In Osteochondral Tissue Engineering, edited by Oliveira, Joaquim Miguel; Pina, Sandra; Reis, Rui L.; Roman, Julio San, 219-240. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-76735-2_10
  3. Canadas, Raphaël F.; Marques, Alexandra P.; Reis, Rui L.; Oliveira, J. Miguel. "Bioreactors and Microfluidics for Osteochondral Interface Maturation". In Advances in Experimental Medicine and Biology, edited by Oliveira, Joaquim Miguel; Pina, Sandra; Reis, Rui L.; Roman, Julio San, 395-420. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-76735-2_18
  4. Canadas, Raphaël F.; Marques, Alexandra P.; Reis, Rui Luís; Oliveira, Joaquim Miguel. "Osteochondral Tissue Engineering and Regenerative Strategies". In Regenerative Strategies for the Treatment of Knee Joint Disabilities, 213-233. Portugal: Springer International Publishing, 2016.
    Published • 10.1007/978-3-319-44785-8_11
  5. Pereira, H.; Silva-Correia, Joana; Canadas, Raphaël F.; Pereira, Diana R.; Yan, Le P.; Oliveira, Ana L.; Oliveira, Joaquim M.; et al. "Engenharia de tecidos e medicina regenerativa na abordagem das lesões do tornozelo". In Pé e Tornozelo, edited by Amado, Paulo; Gomes, André; Felicíssimo, Paulo; Côrte-Real, Nuno, 441-453. Lidel, 2015.
    Published
  6. Pereira, Hélder; Silva-Correia, Joana; Correia, Sandra I.; Canadas, Raphaël F.; Ripoll, Pedro; Espregueira-Mendes, João; Oliveira, Joaquim M.; Reis, Rui L.. "A Engenharia de Tecidos nas lesões desportivas". In Traumatologia Desportiva, 320-335. Portugal: LIDEL, 2014.
    Published • 10.1007/978-3-662-49376-2
Conference poster
  1. Canadas, Raphaël F.; Ren, Tanchen; Tocchio, Alessandro; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.; Demirci, Utkan. "3-D neural columns with tunable width and orientation". Paper presented in BIONECA, 2018.
  2. Canadas, Raphaël F.; da Silva Morais, Alain; Patrício, Pedro; Gasperini, Luca; Vilela, Carlos A.; Costa, João B.; Araújo, Nuno A. M.; et al. "Convection as a driving mechanism for gradients formation in interfaced gels for 3-D tissue interfaces". Paper presented in Chem2Nature, 2018.
  3. Canadas, Raphaël F.; Tocchio, Alessandro; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.; Demirci, Utkan. "Gradient Control and Microporosity Guidance in 3D Structures for Regenerative Medicine". Paper presented in Stanford Bio-X IIP Symposium, 2017.
  4. Canadas, Raphaël F.; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.; Demirci, Utkan. "Three-dimensional gradients in isotropic and anisotropic mimetic scaffolds for regenerative medicine applications". Paper presented in TERM STEM, 2017.
  5. Canadas, Raphaël F.; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.. "Hybrid Bilayered Sponges For Dynamic Osteoarthritic 3D In vitro Model". Paper presented in TERMIS-AM16, 2016.
  6. Canadas, Raphaël F.; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.. "Rotational dual-chamber bioreactor to generate 3D tissue interfaces". Paper presented in TERMIS-EU16, 2016.
  7. Canadas, Raphaël F.; Marques, Alexandra P.; Reis, Rui L.; Oliveira, Joaquim M.. "Comparison of bilayered structures of gellan gum with and without incorporation of gold nanorods for osteochondral tissue engineering". Paper presented in World Biomaterials Congress, 2016.
  8. Canadas, Raphaël F.; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.. "Rotational Dual-Chamber Bioreactor designed for Tissue Engineered Interfaces". Paper presented in European Society of Biomaterials, 2015.
    10.1109/embc.2013.6610974
  9. Canadas, Raphaël F.; Cavalheiro, João M. B. T.; Guerreiro, João D. T.; de Almeida, M. Catarina M.D.; Pollet, Eric; da Silva, Cláudia L.; da Fonseca, M. M. R.; Ferreira, Frederico C.. "Polyhydroxyalkanoates Fibrous Scaffolds for Support of Mesenchymal Stem cells". Paper presented in 1st CLUSTER Workshop in Materials and Nanotechnology, 2013.
  10. Canadas, Raphaël F.; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.. "Bilayered Structures Developed for Osteochondral In vitro Model". Paper presented in III Meeting of ICVS/3B's Associate Laboratory, 2013.
  11. Canadas, Raphaël F.; Cavalheiro, João M. B. T.; Guerreiro, João D. T.; Almeida, M. Catarina M. D. de; Pollet, Eric D.; da Silva, Cláudia L.; da Fonseca, M. M. R.; Ferreira, Frederico C.. "Polyhydroxyalkanoates: their production from crude glycerol, electrospinning in fibrous scaffolds and use to support mesenchymal stem cells culture". Paper presented in 9th European Congress of Chemical Engineering & 2nd European Congress of Applied Biotechnology, 2013.
Journal article
  1. Gonçalves, Cristiana; Silva, Simone S.; Gomes, Joana M.; Oliveira, Isabel M.; Canadas, Raphaël F.; Maia, F. Raquel; Radhouani, Hajer; et al. "Ionic Liquid-Mediated Processing of SAIB-Chitin Scaffolds". ACS Sustainable Chemistry & Engineering (2020): http://dx.doi.org/10.1021/acssuschemeng.0c00385.
    Accepted • 10.1021/acssuschemeng.0c00385
  2. Ribeiro, Viviana P.; Pina, Sandra; Canadas, Raphaël F.; da Silva Morais, Alain; Vilela, Carlos; Vieira, Silvia; Cengiz, Ibrahim Fatih; Reis, Rui L.; Oliveira, Joaquim Miguel. "In Vivo Performance of Hierarchical HRP-Crosslinked Silk Fibroin/ß-TCP Scaffolds for Osteochondral Tissue Regeneration". Regenerative Medicine Frontiers (2019): http://dx.doi.org/10.20900/rmf20190007.
    10.20900/rmf20190007
  3. Canadas, Raphaël F.; Ren, Tanchen; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.; Demirci, Utkan; Canadas, Raphael F.. "Biochemical Gradients to Generate 3D Heterotypic-Like Tissues with Isotropic and Anisotropic Architectures". Advanced Functional Materials 28 48 (2018): 1804148. http://dx.doi.org/10.1002/adfm.201804148.
    Published • 10.1002/adfm.201804148
  4. Ribeiro, Viviana P.; da Silva Morais, Alain; Maia, F. Raquel; Canadas, Raphael F.; Costa, João B.; Oliveira, Ana L.; Oliveira, Joaquim M.; et al. "Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration". Acta Biomaterialia 72 (2018): 167-181. http://dx.doi.org/10.1016/j.actbio.2018.03.047.
    Published • 10.1016/j.actbio.2018.03.047
  5. Pina, S.; Canadas, R.F.; Jiménez, G.; Perán, M.; Marchal, J.A.; Reis, R.L.; Oliveira, J.M.. "Biofunctional Ionic-Doped Calcium Phosphates: Silk Fibroin Composites for Bone Tissue Engineering Scaffolding". Cells Tissues Organs 204 3-4 (2017): 150-163. http://dx.doi.org/10.1159/000469703.
    Published • 10.1159/000469703
  6. Canadas, Raphael F.; Marques, A. P.; Oliveira, J. M.; Reis, R. L.; Demirci, U.; Canadas, R. F.; Reis, R.. "Dynamic platform to recreate an osteoarthritic 3D in vitro model". Tissue Engineering Part A 22 S1 (2016): S-1. http://dx.doi.org/10.1089/ten.tea.2016.5000.abstracts.
    Published • 10.1089/ten.tea.2016.5000.abstracts
  7. Pina, Sandra; Jimenez, Gema; Canadas, Raphaël F.; Maia, F. Raquel; Marques, Alexandra P.; Oliveira, Joaquim M.; Reis, Rui L.. "Calcium Phosphates-based Biomaterials with Sr- and Zn-Dopants for Osteochondral Tissue Engineering". Tissue Engineering Part A 21 S1 (2015): S-1. http://dx.doi.org/10.1089/ten.tea.2015.5000.abstracts.
    Published • 10.1089/ten.tea.2015.5000.abstracts
  8. Canadas, Raphaël F.; Cavalheiro, João M.B.T.; Guerreiro, João D.T.; de Almeida, M. Catarina M.D.; Pollet, Eric; da Silva, Cláudia Lobato; da Fonseca, M.M.R.; et al. "Polyhydroxyalkanoates: Waste glycerol upgrade into electrospun fibrous scaffolds for stem cells culture". International Journal of Biological Macromolecules 71 (2014): 131-140. http://dx.doi.org/10.1016/j.ijbiomac.2014.05.008.
    Published • 10.1016/j.ijbiomac.2014.05.008
  9. Canadas, Raphael Faustino; Marques, A. P.; Oliveira, Joaquim M.; Reis, R. L.. "Development of novel bilayered structures to be used as an osteochondral in vitro model". Journal of Tissue Engineering and Regenerative Medicine 7 (2013): 6-52. http://dx.doi.org/10.1002/term.1822.
    10.1002/term.1822
Thesis / Dissertation
  1. Canadas, Raphaël F.. "Advanced technological approaches for 3-D hierarchical living tissues". PhD, Universidade do Minho, 2018. http://hdl.handle.net/1822/55976.
  2. Canadas, Raphaël F.. "Electrospun nanofibers for human stem cell cultivation". Master, Universidade de Lisboa Instituto Superior Técnico, 2011.

Intellectual property

Patent
  1. Canadas, Raphaël F.; Oliveira, Joaquim M.; Marques, Alexandra P.; Reis, Rui L.. 2016. "Multi-chamber bioreactor, methods and uses".
    Granted/Issued
  2. Canadas, Raphaël F.; Oliveira, Joaquim M.; Marques, Alexandra P.; Reis, Rui L.. 2014. "Rotational dual chamber bioreactor: methods and uses thereof".
    Granted/Issued

Other

Spin-off company
  1. 2020. B-CULTURE. https://bioreactcompany.wixsite.com/bioreact.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11 Generation of a 3D gradient inducing a precise control over phenotype and pre-vasculature for osteochondral tissue modelling EORS
(Maastricht, Netherlands)
2019/05/20 4D Models for Health Pint of Science
(Braga, Portugal)
2019/05 Biochemical gradients to form a 3-D osteochondral in vitro model TERMIS-EU 2019
TERMIS (Rhodes, Greece)
2019/02 B-CULTURE - 4D human-based screening SFB2019 BPC
Society for Biomaterials (Seattle, United States)
2019 Surgical implant development for osteochondral regeneration Preclinical Imaging Life Sciences
Bruker, Dias de Sousa (Porto, Portugal)
2018 BIOreACT - Goodbye Flattened Biology Regenerative Medicine Crossroad in Tokyo #8
Forum for Innovative Regenerative Medicine, Regenerative Medicine Industrialization Task Force (Tóquio, Japan)
2018 How to do a PhD: From PhD candidate to PhD survivor Gene2Skin
(Porto, Portugal)
2018 Goodbye Flattened Biology by BIOreACT TERMIS-W BPC
(Quioto, Japan)
2017 Anisotropic methacrylated network for the development of an in vitro three-dimensional neural model TERMIS-AP
(Nantong, China)
2017 Anatomic three-dimensional anisotropy engineered for in vitro tissue models Chem2Nature
(Porto, Portugal)
2017 Creating technology for regenerative medicine: a multidisciplinary and multicultural approach Entrepreneurship, Innovation and Business Creation
(Porto, Portugal)
2016 BIOreACT project, Business Plan Competition TERMIS-EU BPC
(Uppsala, Sweden)
2015 Rotational Dual Chamber Bioreactor for Interfaced Engineered Tissue Models Society For Biomaterials
(Charlotte, United States)
2015 Rotational Dual-Chamber Bioreactor designed for Tissue Engineered Interfaces European Conference on Biomaterials
(Krakow, Poland)
2013 Novel Osteochondral 3D Model as an In vitro Technological Platform for In vitro Screening TERMIS-EU
(Istambul, Turkey)
2013 Development of novel bilayered structures to be used as an osteochondral in vitro model TERM STEM
(Porto, Portugal)
2013 Fabrication and application of electrospun fibrous scaffolds, using polyhydroxyalkanoates bioproduced from crude glycerol, to support human mesenchymal stem cell cultivation European Symposium on Biopolymers
(Lisboa, Portugal)
2012 Gellan gum-based hydrogels for the tissue engineering of complex tissues International Showcase for Nanotechnologies
NanotechItaly 2012 (Italy)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016 - Current Participated in the organisation of the 11th EYCN Delegates Assembly 2016 Organizing Team (2016/04/26 - 2016/04/30)
Congress (Co-organisor)
 European Young Chemists' Network, Portugal
2012 - 2017 Participated in the organisation of scientific conferences/meetings, namely TERMSTEM 12-17 (2012 - 2017)
Conference (Co-organisor)
 TERM STEM, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018 - 2018 Raphaël was invited to the Panel of the Healthcare Session of the Green Sands Equity Global Summit 2018, in San Francisco, USA, as founder of B-CULTURE, sharing the session with Low (NeuroVigil), de Souza (Illumina), and Ramamoorthi (Encoded Genomics).
Congress
 Green Sands Equity Global Summit
Green Sands Equity, United States

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016 - 2016 Lectured: Hands-on Training Practical session on Micro-computed tomography analysis, under the 3rd International Meeting - The Meniscus 2016 Hands-on Training Practical session on Micro-computed tomography analysis (Outros)
2015 - 2015 Invited by the doctoral program TERM&SC from University of Minho to give the lesson "Bioreactors I", 2015 TERM&SC (Doutoramento) Universidade do Minho, Portugal

Interview (tv / radio show)

Program Topic
2015 - 2015 Futuro Hoje Medicina Regenerativa e Engenharia de Tecidos

Journal scientific committee

Journal title (ISSN) Publisher
2022/01/01 - Current Guest Editor (2590-0935) Medicine in Novel Technology and Devices
2019/01 - Current Stem Cells International (1687-9678) Hindawi Publishing Corporation (Sage-Hindawi Access to Research)
2015 - Current Journal of Tissue Engineering and Regenerative Medicine (1932-7005) Wiley (John Wiley & Sons)

Mentoring / Tutoring

Topic Student name
2018 - Current 3D blood-brain-barrier model for cancer drugs testing. Fernandes, Diogo C.
Distinctions

Award

2019 Selected for the 4 finalists of the Business Plan Competition of the Society for Biomaterials 2019 Congress
Society For Biomaterials, United States
2019 Selected for the 10 finalists of the EIT Health Innostars Awards 2019
2019 Best Poster Presentation, 3D structures with tunable porosity for in vitro anisotropic neural models.
Journal of Materials Chemistry B, Royal Society of Chemistry, United Kingdom
2019 Selected for the final in Health sector of the Emerging Technologies Competition of the Royal Society of Chemistry
Royal Society of Chemistry, United Kingdom
2016 Honorable Mention on the Award “Príncipe da Beira” Biomedical Sciences
Fundação Dom Manuel II, Portugal
2016 Honorable Mention for the selection of the project BIOreACT
Tissue Engineering & Regenerative Medicine International Society, Belgium
2012 Kima Kit Competition
Cellix Ltd, Ireland

Other distinction

2018 Selected to participate in IN.AVE Entrepreneurship program. Advanced Program for Accelerating Ideas
Comunidade Intermunicipal do Ave, Portugal
2018 Selected for the 5 finalists of the Tissue Engineering and Regenerative Medicine (TERMIS) World Congress Business Plan Competition 2018
Tissue Engineering & Regenerative Medicine International Society, Belgium
2015 Highlighted by the TV show ‘Futuro Hoje’ from the Portuguese TV Channel SIC
SIC, Portugal
2014 Selected to participate in COHiTEC 2014
COTEC Portugal, Portugal