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Claus Maria Azzalin completed the Dottorato di Ricerca in Dottorato di Ricerca in Genetica e Biologia Molecolare in 2001/12/30 by Università degli Studi di Pavia. Is Group leader in Gulbenkian Institute for Molecular Medicine and Invited Associate Professor in Universidade de Lisboa Faculdade de Medicina, Founder, consultant and shareholder in TessellateBIO. Published 52 articles in journals. Has 3 section(s) of books. Has 3 patent(s) registered. Organized 7 event(s). Supervised 12 PhD thesis(es). Supervised 10 MSc dissertation(s). Has received 7 awards and/or honors. Participates and/or participated as Co-Principal Investigator (Co-PI) in 5 project(s) and Principal investigator in 22 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Biology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Telomeres; transcription; TERRA; genome stability; cancer; aging; chromosome evolution; long noncoding RNA; heterochromatin; DNA damage; Biology and Medicine; Experimental Medicine; Basic Biological Research; epigenetics; RNA; chromatin; telomerase; senescence; ribonucleoprotein; karyotype evolution; replications stress; cancer therapy; Leishmania major; X chromosome; ALT cancers; interferon response; UPF1; DNA methylation; metabolomics; .
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Identification

Personal identification

Full name
Claus Maria Azzalin

Citation names

  • Azzalin, Claus

Author identifiers

Ciência ID
9F19-476D-AA2B

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Italian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2001/12/30
Concluded
 Dottorato di Ricerca in Genetica e Biologia Molecolare (Dottorato di Ricerca)
Major in Genetics and Molecular Biology
Università degli Studi di Pavia, Italy
"Intrachromosomal telomeric repeats in mammalian genomes" (THESIS/DISSERTATION)
 N/A
Affiliation

Positions / Appointments

Category
Host institution 		Employer
2024/10/01 - Current Group leader Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2021/01/01 - Current Invited Associate Professor Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2016/10/01 - 2024/09/30 Group Leader Instituto de Medicina Molecular, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2009/03/01 - 2016/09/30 Assistant Professor Eidgenössische Technische Hochschule Zürich Departement Biologie, Switzerland
Eidgenössische Technische Hochschule Zürich, Switzerland

Others

Category
Host institution 		Employer
2020/11/01 - Current Founder, consultant and shareholder TessellateBIO, Netherlands
2008/02/01 - 2016/09/30 Group Leader Eidgenössische Technische Hochschule Zürich Departement Biologie, Switzerland
Institute of Biochemistry (IBC) of ETH Zürich, Switzerland
2002/04/01 - 2008/01/31 Post Doctoral Fellow École polytechnique fédérale de Lausanne Faculté des sciences de la vie Institut Suisse de Recherche Experimentale sur le Cancer, Switzerland
2001/08/01 - 2002/03/31 Post Doctoral Fellow Memorial Sloan Kettering Cancer Center, United States
2000/11/01 - 2001/07/31 Post Doctoral Fellow Università degli Studi di Pavia, Italy
Projects

Grant

Designation Funders
2024/05/01 - Current TRIAD: Enhancing Synergism on Telomere Function in Health and Disease
HORIZON-WIDERA 101158508 TRIAD
Co-Principal Investigator (Co-PI)
Horizon Europe Excellent Science
Ongoing
2021/12/01 - Current Regulatory RNA-protein interactions at telomeres in healthy cells and during malignant transformation
HR21-00077
Principal investigator
Instituto de Medicina Molecular, Portugal
 La Caixa Foundation
Ongoing
2021/10/01 - Current Study of Alternative Lengthening of Telomeres-associated telomeric replicative stress alleviators - paving avenues towards innovative anti-cancer therapies
PTDC/MED-ONC/7864/2020
Co-Principal Investigator (Co-PI)
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/01 - Current Assembly and functions of the mammalian telomeric deoxyribo/ribonucleoprotein particle at chromosome ends and beyond
PTDC/BIA-MOL/6624/2020
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - Current Decoding the Role of DNA Break-Induced Transcription in Ageing
PTDC/MED-OUT/4301/2020
Co-Principal Investigator (Co-PI)
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/07/15 - 2023/12/14 Poly(A) methylation as novel tool for mRNA-therapeutics
LA/50005/2020
Co-Principal Investigator (Co-PI)
Instituto de Medicina Molecular, Portugal
 Instituto de Medicina Molecular
Concluded
2019/09/01 - 2023/02/28 RNA in disease - RiboMed
GA 857119 - H2020-WIDESPREAD
Principal investigator
Instituto de Medicina Molecular, Portugal

University of Oxford, United Kingdom

Weizmann Institute of Science, Israel

Max Delbrück Centrum für Molekulare Medizin Experimental and Clinical Research Center, Germany
EU Framework Programme for Research and Innovation Science with and for Society
Concluded
2017/01/01 - 2022/12/31 TERRA and telomere transcription: towards therapies for healthy aging
IG 3576
Principal investigator
Instituto de Medicina Molecular, Portugal
 Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH
Concluded
2016/10/17 - 2021/10/16 TERRA and telomere transcription at the crossroads of cancer and aging
IF/01269/2015/CP1287/CT0003
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2021/09/30 Telomeric R-loop-mediated recombination in the alternative lengthening of telomeres pathway: towards designing novel therapeutic avenues for cancer therapy
PTDC/MED-ONC/28282/2017
Co-Principal Investigator (Co-PI)
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/06/01 - 2021/07/31 TERRA and telomerase-mediated telomere elongation: unveiling novel molecular pathways towards the development of innovative therapeutic approaches for cancer treatment
PTDC/BIA-MOL/29352/2017
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/01/01 - 2018/12/31 Sensing Telomeric Fusions in Cells.
internal competitive grant
Principal investigator
Instituto de Medicina Molecular, Portugal
 Instituto de Medicina Molecular
Concluded
2015/04/01 - 2018/08/31 The multiple roles of TERRA in telomere length maintenance, telomere integrity, cancer and cellular senescence
31003A_160338
Principal investigator
Eidgenossische Technische Hochschule Zürich Institut für Bau- und Infrastrukturmanagement, Switzerland

Instituto de Medicina Molecular, Portugal
Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
Concluded
2013/01/01 - 2016/12/31 The Mpn1 RNA exonuclease: a tool to unveil novel nuclear RNA surveillance pathways
ETH-01 12-2
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Eidgenössische Technische Hochschule Zürich
Concluded
2014/07/01 - 2016/06/30 Telomeric Repeat-containing RNA and Alternative Lengthening of Telomeres
GHDE KXQ7-DZZ (1299/M)
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Promedica Stiftung
Concluded
2014/06/01 - 2016/05/31 The human helicase UPF1: safeguarding the integrity of the genome through resolution of hazardous RNA:DNA hybrids
ETH-07 14-1
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Eidgenössische Technische Hochschule Zürich
Concluded
2013/04/01 - 2015/03/31 Non-coding nuclear RNAs: from telomere integrity to RNA surveillance to pre-mRNA splicing
PP00P3_144917
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
Concluded
2009/10/01 - 2014/09/30 BFTERRA: Biogenesis and Functions of Telomeric Repeat-containing RNA
242714
Principal investigator
European Research Council
Concluded
2009/04/01 - 2013/03/31 Transcription of telomeric heterochromatin
PP00P3_1123356
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
Concluded
2009/08/01 - 2012/07/31 Characterization of human UPF1 helicase functions in replication fork progression and genome stability
ETH-03 08-3
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Eidgenössische Technische Hochschule Zürich
Concluded
2009/01/04 - 2012/03/31 Regolazione dell’RNA telomerico in cellule normali e tumorali
2008-2507
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Fondazione Cariplo
Concluded
2008/06/01 - 2011/05/31 Characterization of UPF1 and hEST1A functions in telomere maintenance
ETH-15 08-1
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Eidgenössische Technische Hochschule Zürich
Concluded
2008/04/01 - 2011/03/31 Biogenesis, regulation and function of telomeric repeat containing RNA at mammalian chromosome ends
31003A-120090
Principal investigator
Eidgenössische Technische Hochschule Zürich, Switzerland
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
Concluded

Contract

Designation Funders
2022/05/01 - 2028/04/30 RNA-protein interactions that remodel human telomere composition and their impact on genome stability and malignant transformation.
2021.00143.CEECIND/CP1673/CT0001
10.54499/2021.00143.CEECIND/CP1673/CT0001
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/10/01 - 2021/09/30 Telomere transcription at the crossroads between cancer and aging
IF/01269/2015
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2013/04/01 - 2015/03/31 Non-coding nuclear RNAs: from telomere integrity to RNA surveillance to pre-mRNA splicing
144917
Principal investigator
Institut für Biochemie Departement Biologie ETH Zürich, Switzerland
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
2009/04/01 - 2013/03/31 Transcription of telomeric heterochromatin
123356
Principal investigator
Institut für Biochemie Departement Biologie ETH Zürich, Switzerland
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
Concluded
Outputs

Publications

Book chapter
  1. Abreu PL; Riva, Valentina; Zardoni Luca; Azzalin, Claus. "Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions". In Telomeres and Telomerase. Cold Spring Harbor Perspectives in Biology, 2025.
    In press
  2. Arora, Rajika; Brun, Catherine M. C.; Azzalin, Claus M.. "TERRA: Long Noncoding RNA at Eukaryotic Telomeres". In Progress in Molecular and Subcellular Biology, 65-94. Springer Berlin Heidelberg, 2010.
    10.1007/978-3-642-16502-3_4
  3. Azzalin, Claus M; Lingner, Joachim; Redon, Sophie. "S. cerevisiae Est1/H. sapiens SMG6 Protein Family Members Function in Telomere Metabolism". In Nonsense-Mediated mRNA Decay. Landes Bioscience, 2005.
Conference poster
  1. Andolfato, Marta; Azzalin, Claus. "Characterization of the long noncoding RNA TERRA in a vertebrate". Paper presented in EMBO workshop ‘Telomere function and evolution in health and disease’ (Rome, Italy), 2024.
  2. Salgado, Sara; Silva, Bruno; Moleirinho, Beatriz; Larcombe, Lee; Azzalin, Claus. "The nucleic acids-binding protein SUB1 supports the viability of ALT cancer cells". Paper presented in EMBO workshop ‘Telomere function and evolution in health and disease’ (Rome, Italy), 2024.
  3. Andolfato, Marta; Azzalin, Claus. "Structure and function of TERRA long noncoding RNA in a vertebrate". Paper presented in 13th EMBO Young Scientists’ Forum (Lisbon, Portugal), 2023.
  4. Domingues-Silva, Beatriz; Azzalin, Claus. "Understanding the functions of telomeric repeat-containing RNAs at non-telomeric loci". Paper presented in 13th EMBO Young Scientists’ Forum (Lisbon, Portugal), 2023.
  5. Riva, Valentina; ABREU, PATRÍCIA; Sarnowski, C; Leitner, A; Azzalin, Claus. "TERRA regulates TRF1 and TRF2 interactions with telomeres". Paper presented in 13th EMBO Young Scientists’ Forum (Lisbon, Portugal), 2023.
  6. Zardoni Luca; Azzalin, Claus. "Characterization of new transcriptional regulators of TERRA". Paper presented in 13th EMBO Young Scientists’ Forum (Lisbon, Portugal), 2023.
  7. Andolfato, Marta; Azzalin, Claus. "Structure and function of the TERRA long noncoding RNA in a vertebrate". Paper presented in 12th European Zebrafish Meeting (Krakow, Poland), 2023.
  8. Andolfato, Marta; Azzalin, Claus. "Structure and function of TERRA transcriptome in a vertebrate". Paper presented in XVI CAML PhD Students Meeting (Lisbon, Portugal), 2023.
  9. Domingues-Silva, Beatriz; Azzalin, Claus. "Understanding the functions of telomeric repeat-containing RNAs at non-telomeric loci". Paper presented in XVI CAML PhD Students Meeting (Lisbon, Portugal), 2023.
  10. Salgado, Sara; Silva, Bruno; Moleirinho, Beatriz; Azzalin, Claus. "Dissecting the functions of SUB1 in the Alternative Lengthening of Telomeres pathway across evolution". Paper presented in XVI CAML PhD Students Meeting (Lisbon, Portugal), 2023.
  11. ABREU, PATRÍCIA; Lee, YW; Azzalin, Claus. "In vitro analysis of the physical interactions of TRF2 with the long noncoding RNA TERRA". Paper presented in RNA in Disease - IX ptRNA meeting (Lisbon, Portugal), 2023.
  12. Domingues-Silva, Beatriz; Azzalin, Claus. "Understanding the functions of telomeric repeat-containing RNAs at non-telomeric loci". Paper presented in RNA in Disease – IX ptRNA meeting (Lisbon, Portugal), 2023.
  13. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "The human telomeric transcriptome". Paper presented in RNA in Disease - IX ptRNA meeting (Lisbon, Portugal), 2023.
  14. Salgado, Sara; Silva, Bruno; Moleirinho, Beatriz; Azzalin, Claus. "SUB1 as a novel regulator in the Alternative Lengthening of Telomeres pathway". Paper presented in RNA in Disease – IX ptRNA meeting (Lisbon, Portugal), 2023.
  15. Zardoni Luca; Azzalin, Claus. "Characterization of shelterin factors as new regulators of TERRA". Paper presented in RNA in Disease - IX ptRNA meeting (Lisbon, Portugal), 2023.
  16. Domingues-Silva, Beatriz; Azzalin, Claus. "Understanding the functions of telomeric repeat-containing RNAs at non-telomeric loci". Paper presented in EMBO workshop ‘Telomere function and evolution in health and disease’ (Tróia, Portugal), 2022.
  17. Riva, Valentina; ABREU, PATRÍCIA; Sarnowski, C; Leitner, A; Azzalin, Claus. "TERRA regulates TRF1 and TRF2 interactions with telomeres". Paper presented in EMBO workshop ‘Telomere function and evolution in health and disease’ (Tróia, Portugal), 2022.
  18. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "The human telomeric transcriptome". Paper presented in EMBO workshop ‘Telomere function and evolution in health and disease’ (Tróia, Portugal), 2022.
  19. ABREU, PATRÍCIA; Lee, YW; Azzalin, Claus. "In vitro analysis of the physical interactions of TRF2 with the long noncoding RNA TERRA". Paper presented in RiboMed Satellite Conference on RNA in Disease (Lisbon, Portugal), 2022.
  20. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "The human telomeric transcriptome". Paper presented in RiboMed Satellite Conference on RNA in Disease (Lisbon, Portugal), 2022.
  21. Riva, Valentina; ABREU, PATRÍCIA; Azzalin, Claus. "TERRA as a master regulator of TRF1 and TRF2 assembly at telomeres". Paper presented in RiboMed Satellite Conference on RNA in Disease (Lisbon, Portugal), 2022.
  22. Domingues-Silva, Beatriz; Azzalin, Claus. "Understanding the functions of TERRA and telR-loops at telomeric DNA far from the ends of chromosomes". Paper presented in RiboMed Satellite Conference on RNA in Disease (Lisbon, Portugal), 2022.
  23. Salgado, Sara; Silva, Bruno; Moleirinho, Beatriz; Azzalin, Claus. "SUB1 as a novel regulator in the Alternative Lengthening of Telomeres pathway". Paper presented in RiboMed Satellite Conference on RNA in Disease (Lisbon, Portugal), 2022.
  24. Domingues-Silva, Beatriz; Azzalin, Claus. "Understanding the functions of TERRA and telR-loops at telomeric DNA far from the ends of chromosomes". Paper presented in XV CAML·V NeurULisboa PhD Students Meeting (Lisbon, Portugal), 2022.
  25. ABREU, PATRÍCIA; Lee, YW; Azzalin, Claus. "In vitro analysis of the physical interactions of TRF2 with the long noncoding RNA TERRA". Paper presented in CSH Telomeres & Telomerase (Virtual meeting), 2021.
  26. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "The human telomeric transcriptome". Paper presented in CSH Telomeres & Telomerase (Virtual meeting), 2021.
  27. Silva, Bruno; Pentz, Richard; Figueira, Ana Margarida; Arora, Rajika; Lee, Yongwoo; Hodson, Charlotte; Wischnewski, Harry; Deans, Andrew J.; Azzalin, Claus. "FANCM restricts R-loop-induced telomeric replication stress in ALT cells". Paper presented in CSHL Meeting ‘Telomeres & Telomerase’ (New York, USA), 2019.
  28. ABREU, PATRÍCIA; Lee, YW; Azzalin, Claus. "In vitro analysis of TRF1-mediated inhibition of TRF2-induced telR-loop formation". Paper presented in XIII Annual CAML PhD Students’ Meeting (Lisbon, Portugal), 2019.
  29. ABREU, PATRÍCIA; Azzalin, Claus. "Plasmid Invasion Assays: a powerful technique to unveil nucleic acid-protein dynamics at chromosome ends". Paper presented in EMBO YIP PhD course (Heidelberg, Germany), 2019.
  30. Pessoa J; Arora, Rajika; Azzalin, Claus. "Live cell visualization of extra-chromosomal telomeric repeats in ALT cancer cells". Paper presented in 18th FEBS Young Scientists' Forum (Prague, Czech Republic), 2018.
  31. ABREU, PATRÍCIA; Lee YW; Azzalin, Claus. "In vitro analysis of TRF1-mediated inhibition of TRF2-induced telR-loop formation". Paper presented in EMBO workshop "Telomere biology in health and human disease " (Tróia, Portugal), 2018.
  32. Lee, Yongwoo; Arora, Rajika; Wischnewski, H.; Azzalin, Claus. "TRF1 suppresses TRF2-stimulated telomeric R-loops to safeguard telomere integrity". Paper presented in EMBO workshop ‘Telomere biology in health and human disease’ (Tróia, Portugal), 2018.
Journal article
  1. Salgado, Sara; Abreu, Patricia L; Moleirinho, Beatriz; Guedes, Daniela S; Larcombe, Lee; Azzalin, Claus. "Human PC4 supports telomere stability and viability in cells utilizing the alternative lengthening of telomeres mechanism". EMBO Reports 25 12 (2024): 5294-5315. https://doi.org/10.1038/s44319-024-00295-3.
    Open access • Published • 10.1038/s44319-024-00295-3
  2. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "TERRA ONTseq: a long-read-based sequencing pipeline to study the human telomeric transcriptome". RNA 30 8 (2024): 955-966. https://doi.org/10.1261/rna.079906.123.
    Open access • Published • 10.1261/rna.079906.123
  3. Azzalin, Claus. "TERRA and the alternative lengthening of telomeres: a dangerous affair". FEBS Letters (2024): https://doi.org/10.1002/1873-3468.14844.
    Open access • Published • 10.1002/1873-3468.14844
  4. Silva, Bruno; Arora, Rajika; Azzalin, Claus M.. "The alternative lengthening of telomeres mechanism jeopardizes telomere integrity if not properly restricted". Proceedings of the National Academy of Sciences 119 39 (2022): http://dx.doi.org/10.1073/pnas.2208669119.
    10.1073/pnas.2208669119
  5. Abreu, Patricia L.; Lee, Yong Woo; Azzalin, Claus M.. "In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2". International Journal of Molecular Sciences 23 18 (2022): 10463. http://dx.doi.org/10.3390/ijms231810463.
    10.3390/ijms231810463
  6. Sabino, João C; de Almeida, Madalena R; Abreu, Patrícia L; Ferreira, Ana M; Caldas, Paulo; Domingues, Marco M; Santos, Nuno C; et al. "Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops". eLife 11 (2022): http://dx.doi.org/10.7554/elife.69476.
    10.7554/elife.69476
  7. De, Sandip; Edwards, David M; Dwivedi, Vibha; Wang, Jianming; Varsally, Wazeer; Dixon, Hannah L; Singh, Anand K; et al. "Genome-wide chromosomal association of Upf1 is linked to Pol II transcription in Schizosaccharomyces pombe". Nucleic Acids Research 50 1 (2021): 350-367. http://dx.doi.org/10.1093/nar/gkab1249.
    10.1093/nar/gkab1249
  8. Silva, Bruno; Arora, Rajika; Bione, Silvia; Azzalin, Claus M.. "TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-24097-6.
    10.1038/s41467-021-24097-6
  9. Morea, Edna Gicela Ortiz; Vasconcelos, Elton Jose Rosas; de Santis Alves, Cristiane; Giorgio, Selma; Myler, Peter J.; Langoni, Helio; Azzalin, Claus Maria; Cano, Maria Isabel Nogueira. "Exploring TERRA during Leishmania major developmental cycle and continuous in vitro passages". International Journal of Biological Macromolecules (2021): http://dx.doi.org/10.1016/j.ijbiomac.2021.01.192.
    10.1016/j.ijbiomac.2021.01.192
  10. Viceconte, Nikenza; Loriot, Axelle; Lona Abreu, Patrícia; Scheibe, Marion; Fradera Sola, Albert; Butter, Falk; De Smet, Charles; et al. "PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells". RNA 27 1 (2020): 106-121. http://dx.doi.org/10.1261/rna.076281.120.
    10.1261/rna.076281.120
  11. Domingues-Silva, Beatriz; Silva, Bruno; Azzalin, Claus M.. "ALTernative Functions for Human FANCM at Telomeres". Frontiers in Molecular Biosciences 6 (2019): http://dx.doi.org/10.3389/fmolb.2019.00084.
    10.3389/fmolb.2019.00084
  12. Hu, Yan; Bennett, Henrietta W.; Liu, Na; Moravec, Martin; Williams, Jessica F.; Azzalin, Claus M.; King, Megan C.. "RNA–DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast". Genetics 213 2 (2019): 431-447. http://dx.doi.org/10.1534/genetics.119.302606.
    10.1534/genetics.119.302606
  13. Silva, Bruno; Pentz, Richard; Figueira, Ana Margarida; Arora, Rajika; Lee, Yong Woo; Hodson, Charlotte; Wischnewski, Harry; Deans, Andrew J.; Azzalin, Claus M.. "FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-10179-z.
    10.1038/s41467-019-10179-z
  14. Lee, Yong Woo; Arora, Rajika; Wischnewski, Harry; Azzalin, Claus M.. "TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops". Nature Structural & Molecular Biology 25 2 (2018): 147-153. http://dx.doi.org/10.1038/s41594-017-0021-5.
    10.1038/s41594-017-0021-5
  15. Buettner, Florian; Jay, Kyle; Wischnewski, Harry; Stadelmann, Thomas; Saad, Shady; Jefimovs, Konstantins; Mansurova, Madina; et al. "Non-targeted metabolomic approach reveals two distinct types of metabolic responses to telomerase dysfunction in S. cerevisiae". Metabolomics 13 5 (2017): http://dx.doi.org/10.1007/s11306-017-1195-x.
    10.1007/s11306-017-1195-x
  16. Zanini, Isabella M. Y.; Soneson, Charlotte; Lorenzi, Luca E.; Azzalin, Claus M.. "Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion". Journal of Cell Science 130 4 (2017): 767-778. http://dx.doi.org/10.1242/jcs.194068.
    10.1242/jcs.194068
  17. Heinrich, Stephanie; Sidler, Corinne L.; Azzalin, Claus M.; Weis, Karsten. "Stem–loop RNA labeling can affect nuclear and cytoplasmic mRNA processing". RNA 23 2 (2016): 134-141. http://dx.doi.org/10.1261/rna.057786.116.
    10.1261/rna.057786.116
  18. Moravec, Martin; Wischnewski, Harry; Bah, Amadou; Hu, Yan; Liu, Na; Lafranchi, Lorenzo; King, Megan C; Azzalin, Claus M. "TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe". EMBO reports 17 7 (2016): 999-1012. http://dx.doi.org/10.15252/embr.201541708.
    10.15252/embr.201541708
  19. Shchepachev, Vadim; Wischnewski, Harry; Soneson, Charlotte; Arnold, Andreas W.; Azzalin, Claus M.. "Human Mpn1 promotes post-transcriptional processing and stability of U6atac". FEBS Letters 589 18 (2015): 2417-2423. http://dx.doi.org/10.1016/j.febslet.2015.06.046.
    10.1016/j.febslet.2015.06.046
  20. Arora, Rajika; Azzalin, Claus M. "Telomere elongation chooses TERRA ALTernatives". RNA Biology 12 9 (2015): 938-941. http://dx.doi.org/10.1080/15476286.2015.1065374.
    10.1080/15476286.2015.1065374
  21. Azzalin, Claus M.; Lingner, Joachim. "Telomere functions grounding on TERRA firma". Trends in Cell Biology 25 1 (2015): 29-36. http://dx.doi.org/10.1016/j.tcb.2014.08.007.
    10.1016/j.tcb.2014.08.007
  22. Lorenzi, Luca E; Bah, Amadou; Wischnewski, Harry; Shchepachev, Vadim; Soneson, Charlotte; Santagostino, Marco; Azzalin, Claus M. "Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels". The EMBO Journal 34 1 (2014): 115-129. http://dx.doi.org/10.15252/embj.201489559.
    10.15252/embj.201489559
  23. Arora, Rajika; Lee, Yongwoo; Wischnewski, Harry; Brun, Catherine M.; Schwarz, Tobias; Azzalin, Claus M.. "RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells". Nature Communications 5 1 (2014): http://dx.doi.org/10.1038/ncomms6220.
    10.1038/ncomms6220
  24. Balistreri, Giuseppe; Horvath, Peter; Schweingruber, Christoph; Zünd, David; McInerney, Gerald; Merits, Andres; Mühlemann, Oliver; Azzalin, Claus; Helenius, Ari. "The Host Nonsense-Mediated mRNA Decay Pathway Restricts Mammalian RNA Virus Replication". Cell Host & Microbe 16 3 (2014): 403-411. http://dx.doi.org/10.1016/j.chom.2014.08.007.
    10.1016/j.chom.2014.08.007
  25. Shchepachev, Vadim; Azzalin, Claus M.. "The Mpn1 RNA exonuclease: Cellular functions and implication in disease". FEBS Letters 587 13 (2013): 1858-1862. http://dx.doi.org/10.1016/j.febslet.2013.05.005.
    10.1016/j.febslet.2013.05.005
  26. Shchepachev, Vadim; Wischnewski, Harry; Missiaglia, Edoardo; Soneson, Charlotte; Azzalin, Claus M.. "Mpn1, Mutated in Poikiloderma with Neutropenia Protein 1, Is a Conserved 3'-to-5' RNA Exonuclease Processing U6 Small Nuclear RNA". Cell Reports 2 4 (2012): 855-865. http://dx.doi.org/10.1016/j.celrep.2012.08.031.
    10.1016/j.celrep.2012.08.031
  27. Bah, Amadou; Azzalin, Claus M.. "The telomeric transcriptome: From fission yeast to mammals". The International Journal of Biochemistry & Cell Biology 44 7 (2012): 1055-1059. http://dx.doi.org/10.1016/j.biocel.2012.03.021.
    10.1016/j.biocel.2012.03.021
  28. Farnung, Benjamin O.; Brun, Catherine M.; Arora, Rajika; Lorenzi, Luca E.; Azzalin, Claus M.. "Telomerase Efficiently Elongates Highly Transcribing Telomeres in Human Cancer Cells". PLoS ONE 7 4 (2012): e35714. http://dx.doi.org/10.1371/journal.pone.0035714.
    10.1371/journal.pone.0035714
  29. Arora, R.; Brun, C. M.; Azzalin, C. M.. "Transcription regulates telomere dynamics in human cancer cells". RNA 18 4 (2012): 684-693. http://dx.doi.org/10.1261/rna.029587.111.
    10.1261/rna.029587.111
  30. Azzalin, Claus M.. "UPF1: a leader at the end of chromosomes". Nucleus 3 1 (2012): 16-21. http://dx.doi.org/10.4161/nucl.18929.
    10.4161/nucl.18929
  31. Bah, Amadou; Wischnewski, Harry; Shchepachev, Vadim; Azzalin, Claus M.. "The telomeric transcriptome of Schizosaccharomyces pombe". Nucleic Acids Research 40 7 (2011): 2995-3005. http://dx.doi.org/10.1093/nar/gkr1153.
    10.1093/nar/gkr1153
  32. Chawla, Raghav; Redon, Sophie; Raftopoulou, Christina; Wischnewski, Harry; Gagos, Sarantis; Azzalin, Claus M. "Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication". The EMBO Journal 30 19 (2011): 4047-4058. http://dx.doi.org/10.1038/emboj.2011.280.
    10.1038/emboj.2011.280
  33. Farnung, Benjamin O.; Giulotto, Elena; Azzalin, Claus M.. "Promoting transcription of chromosome ends". Transcription 1 3 (2010): 140-143. http://dx.doi.org/10.4161/trns.1.3.13191.
    10.4161/trns.1.3.13191
  34. Nergadze, S. G.; Farnung, B. O.; Wischnewski, H.; Khoriauli, L.; Vitelli, V.; Chawla, R.; Giulotto, E.; Azzalin, C. M.. "CpG-island promoters drive transcription of human telomeres". RNA 15 12 (2009): 2186-2194. http://dx.doi.org/10.1261/rna.1748309.
    10.1261/rna.1748309
  35. Azzalin, Claus M.; Lingner, Joachim. "Telomeres: The silence is broken". Cell Cycle 7 9 (2008): 1161-1165. http://dx.doi.org/10.4161/cc.7.9.5836.
    10.4161/cc.7.9.5836
  36. Chawla, R.; Azzalin, C.M.. "The telomeric transcriptome and SMG proteins at the crossroads". Cytogenetic and Genome Research 122 3-4 (2008): 194-201. http://dx.doi.org/10.1159/000167804.
    10.1159/000167804
  37. Luke, Brian; Azzalin, Claus M.; Hug, Nele; Deplazes, Anna; Peter, Matthias; Lingner, Joachim. "Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay". Nucleic Acids Research 35 22 (2007): 7688-7697. http://dx.doi.org/10.1093/nar/gkm912.
    10.1093/nar/gkm912
  38. Azzalin, C. M.; Reichenbach, P.; Khoriauli, L.; Giulotto, E.; Lingner, J.. "Telomeric Repeat Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends". Science 318 5851 (2007): 798-801. http://dx.doi.org/10.1126/science.1147182.
    10.1126/science.1147182
  39. Azzalin, Claus M.; Lingner, Joachim. "Damage control". Nature 448 7157 (2007): 1001-1002. http://dx.doi.org/10.1038/4481001a.
    10.1038/4481001a
  40. Azzalin, Claus M.; Lingner, Joachim. "The Double Life of UPF1 in RNA and DNA Stability Pathways". Cell Cycle 5 14 (2006): 1496-1498. http://dx.doi.org/10.4161/cc.5.14.3093.
    10.4161/cc.5.14.3093
  41. Azzalin, Claus M.; Lingner, Joachim. "The Human RNA Surveillance Factor UPF1 Is Required for S Phase Progression and Genome Stability". Current Biology 16 4 (2006): 433-439. http://dx.doi.org/10.1016/j.cub.2006.01.018.
    10.1016/j.cub.2006.01.018
  42. Rebuzzini, Paola; Khoriauli, Lela; Azzalin, Claus M.; Magnani, Elisa; Mondello, Chiara; Giulotto, Elena. "New mammalian cellular systems to study mutations introduced at the break site by non-homologous end-joining". DNA Repair 4 5 (2005): 546-555. http://dx.doi.org/10.1016/j.dnarep.2004.12.011.
    10.1016/j.dnarep.2004.12.011
  43. Paillusson, A.; N. Hirschi; C. Vallan; O. Mühlemann. "A GFP-based reporter system to monitor nonsense-mediated mRNA decay". Nucleic Acids Research 33 6 (2005): e54-e54. http://dx.doi.org/10.1093/nar/gni052.
    10.1093/nar/gni052
  44. Nergadze, S. G.; M. Rocchi; C.M. Azzalin; C. Mondello. "Insertion of Telomeric Repeats at Intrachromosomal Break Sites During Primate Evolution". Genome Research 14 9 (2004): 1704-1710. http://dx.doi.org/10.1101/gr.2778904.
    10.1101/gr.2778904
  45. Azzalin, C. M.; Lingner, J.. "CELL BIOLOGY: Telomere Wedding Ends in Divorce". Science 304 5667 (2004): 60-62. http://dx.doi.org/10.1126/science.1096809.
    10.1126/science.1096809
  46. Reichenbach, Patrick; Höss, Matthias; Azzalin, Claus M.; Nabholz, Markus; Bucher, Philipp; Lingner, Joachim. "A Human Homolog of Yeast Est1 Associates with Telomerase and Uncaps Chromosome Ends When Overexpressed". Current Biology 13 7 (2003): 568-574. http://dx.doi.org/10.1016/s0960-9822(03)00173-8.
    10.1016/s0960-9822(03)00173-8
  47. Ruiz-Herrera, A.; García, F.; Azzalin, C.; Giulotto, E.; Egozcue, J.; Ponsà, M.; Garcia, M.. "Distribution of intrachromosomal telomeric sequences (ITS) on Macaca fascicularis (Primates) chromosomes and their implication for chromosome evolution". Human Genetics 110 6 (2002): 578-586. http://dx.doi.org/10.1007/s00439-002-0730-6.
    10.1007/s00439-002-0730-6
  48. Faravelli, Maura; Azzalin, Claus M; Bertoni, Livia; Chernova, Olga; Attolini, Carmen; Mondello, Chiara; Giulotto, Elena. "Molecular organization of internal telomeric sequences in Chinese hamster chromosomes". Gene 283 1-2 (2002): 11-16. http://dx.doi.org/10.1016/s0378-1119(01)00877-0.
    10.1016/s0378-1119(01)00877-0
  49. Azzalin, Claus M.; Nergadze, Solomon G.; Giulotto, Elena. "Human intrachromosomal telomeric-like repeats: sequence organization and mechanisms of origin". Chromosoma 110 2 (2001): 75-82. http://dx.doi.org/10.1007/s004120100135.
    10.1007/s004120100135
  50. Mondello, Chiara; Pirzio, Livia; Azzalin, Claus M.; Giulotto, Elena. "Instability of Interstitial Telomeric Sequences in the Human Genome". Genomics 68 2 (2000): 111-117. http://dx.doi.org/10.1006/geno.2000.6280.
    10.1006/geno.2000.6280
  51. Fukagawa, T.; Hayward, N.; Yang, J.; Azzalin, C.; Griffin, D.; Stewart, A. F.; Brown, W.. "The chicken HPRT gene: a counter selectable marker for the DT40 cell line". Nucleic Acids Research 27 9 (1999): 1966-1969. http://dx.doi.org/10.1093/nar/27.9.1966.
    10.1093/nar/27.9.1966
  52. Azzalin, C.M.; Mucciolo, E.; Bertoni, L.; Giulotto, E.. "Fluorescence in situ hybridization with a synthetic (T2AG3)n polynucleotide detects several intrachromosomal telomere-like repeats on human chromosomes". Cytogenetic and Genome Research 78 2 (1997): 112-115. http://dx.doi.org/10.1159/000134640.
    10.1159/000134640
Preprint
  1. Salgado, Sara; Abreu, Patricia L.; Moleirinho, Beatriz; Larcombe, Lee; Azzalin, Claus. "Human PC4 supports telomere stability and viability in cells utilizing the alternative lengthening of telomeres mechanism". 2024. https://doi.org/10.1101/2024.08.19.608623.
    10.1101/2024.08.19.608623
  2. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus M.. "TERRA ONTseq: a long read-based sequencing pipeline to study the human telomeric transcriptome". 2023. http://dx.doi.org/10.1101/2023.11.30.569384.
    10.1101/2023.11.30.569384
  3. Silva, Bruno; Arora, Rajika; Azzalin, Claus M.. "TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells". 2021. http://dx.doi.org/10.1101/2021.02.18.431840.
    10.1101/2021.02.18.431840
  4. De, Sandip; Dwivedi, Vibha; Wang, Jianming; Edwards, David M.; Varsally, Wazeer; Singh, Anand K.; Dixon, Hannah L.; et al. "Genome-wide chromosomal association of Upf1 is linked to Pol II transcription in Schizosaccharomyces pombe". 2021. http://dx.doi.org/10.1101/2021.04.12.437332.
    10.1101/2021.04.12.437332
  5. Sabino, João C.; de Almeida, Madalena R.; Abreu, Patricia L.; Ferreira, Ana M.; Domingues, Marco M.; Santos, Nuno C.; Azzalin, Claus; Grosso, Ana R.; de Almeida, Sérgio F.. "Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops". 2021. http://dx.doi.org/10.1101/2021.04.26.441414.
    10.1101/2021.04.26.441414
  6. Hu, Yan; Bennett, Henrietta W.; Liu, Na; Moravec, Martin; Williams, Jessica F.; Azzalin, Claus; King, Megan C.. "RNA-DNA hybrids support recombination-based telomere maintenance in fission yeast". 2018. http://dx.doi.org/10.1101/458968.
    10.1101/458968
Thesis / Dissertation
  1. "Rebelo, J. "TERRA-mediated recruitment of SMARCAL1 in response to Telomeric Replication Stress"". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2023. http://hdl.handle.net/10362/176205.
  2. "Justo, I. "Exploring the role of the ESCRT-III proteins in response to telomeric replication stress in ALT cancer cells"". Master, Universidade NOVA de Lisboa NOVA Medical School, 2023. http://hdl.handle.net/10362/164719.
  3. "Abreu, PL. "Characterization of the physical and functional interactions between human TRF proteins and the telomeric long noncoding RNA TERRA"". PhD, Universidade de Lisboa Faculdade de Medicina, 2023. http://hdl.handle.net/10451/63706.
  4. "Salgado, S. "Exploring the roles of PC4 in the Alternative Lengthening of Telomeres pathway"". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2022. http://hdl.handle.net/10362/130700.
  5. "Alves, M. "TERRA Transcription Profiles in Human Cancer Cells"". Master, Universidade de Lisboa Instituto Superior Técnico, 2021. https://fenix.tecnico.ulisboa.pt/departamentos/deec/dissertacao/846778572212732.
  6. "Moleirinho, B. "Novel Regulators of Telomerase-Independent Telomere Elongation in ALT Cancer Cells"". Master, Universidade de Lisboa Faculdade de Ciências, 2021. http://hdl.handle.net/10451/47971.
  7. "Gaio, L. "The roles of telR-loops in the stability of telomeres in primary and telomerase-positive cancer cells"". Master, Universidade de Lisboa Faculdade de Farmácia, 2020. http://hdl.handle.net/10451/54038.
  8. "Pentz, R. "FANCM translocase promotes telomere stability and cell viability in ALT (Alternative Lengthening of Telomeres) cells"". PhD, Eidgenössische Technische Hochschule Zürich Institut fur Biochemie, 2018. https://doi.org/10.3929/ethz-b-000297279.
  9. "Zanini, I. "Functions of human Cactin in pre-mRNA splicing and chromosome stability"". PhD, Eidgenössische Technische Hochschule Zürich Institut fur Biochemie, 2016. https://doi.org/10.3929/ethz-a-010637749.
  10. "Moravec, M. "TERRA and telomere transcription at the crossroads between telomere length regulation and telomere integrity in Schizosaccharomyces pombe"". PhD, Eidgenössische Technische Hochschule Zürich, 2016. https://doi.org/10.3929/ethz-a-010657794.
  11. "Lorenzi, L. "Cactin family protein CAY1 controls silencing of telomeres and LTR retrotransposons in fission yeast"". PhD, Eidgenössische Technische Hochschule Zürich Institut fur Biochemie, 2014. https://doi.org/10.3929/ethz-a-010379167.
  12. "Shchepachev, V. "The Mpn1 RNA Exonuclease: Cellular Functions and Implication in Disease"". PhD, Eidgenössische Technische Hochschule Zürich, 2014. https://doi.org/10.3929/ethz-a-010150212.
  13. "Brun, C. "Studying TERRA-associated functions using a human cellular system, in which the transcription of a unique telomere can be induced at will"". PhD, Eidgenössische Technische Hochschule Zürich, 2012. https://doi.org/10.3929/ethz-a-009758844.
  14. "Farnung, B. "Characterization of human telomeric repeat-containing RNA biogenesis and function"". PhD, Eidgenössische Technische Hochschule Zürich, 2012. https://doi.org/10.3929/ethz-a-007558046.
  15. "Chawla, R. "Role of human UPF1 in telomere stability processes"". PhD, Eidgenössische Technische Hochschule Zürich, 2011. https://doi.org/10.3929/ethz-a-006490883.

Intellectual property

Patent
  1. de ALMA, Sérgio / MORGADO, Cristiana/AZZALIN, Claus. 2023. "Induction of Cellular Lethality in Cancer". Portugal.
    Pending
  2. FIGUEIREDO, Luisa Miranda/VIEGAS, Idálio De Jesus Contreiras/AZZALIN, Claus Maria/RIVA, Valentina. 2022. "Methods of RNA stabilisation". Portugal.
    Pending
  3. PICKETT, Hilda Amelia/AZZALIN, Claus Maria/SOBINOFF, Alexander Peter. 2020. "Treatment of ALT cancers".
    Pending
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/06/01 Invited speaker for the European Human Genetics Conference, Berlin, Germany - "Telomere transcription, TERRA and telomere maintenance. " European Human Genetics Conference
(Berlin, Germany)
2024/02/19 Invited speaker for seminar at University of Trento, Dept. of Cellular, Computational and Integrative Biology (CIBIO) - "Telomere transcription and shelterin interactions at human telomeres"
University of Trento, Dept. of Cellular, Computational and Integrative Biology (CIBIO) (Trento, Italy)
2024/02/16 Invited speaker for seminar at University La Sapienza, Dept. of Genetics - "TERRA-shelterin interactions a human telomeres"
University La Sapienza, Dept. of Genetics (Rome, Italy)
2023/12/07 Invited speaker for the SFB 1361 & 4R-RTG Seminars at the Institute of Molecular Biology - "The interplay between telomere transcription and shelterin at human telomeres" SFB 1361 & 4R-RTG Seminars
Institute of Molecular Biology (Mainz, Germany)
2023/10/12 Invited speaker for the Panel Discussion on Diversity and Inclusion at the 13th EMBO Young Scientists' Forum - "LGBTQ+ representation in STEM" 13th EMBO Young Scientists’ Forum
(Lisbon, Portugal)
2023/07/13 Invited talk at the XVI Annual Congress of Biotechnology - "Ins and outs of transcription at human chromosome ends" XVI Annual Congress of Biotechnology
(Badajoz, Spain)
2023/02/27 Invited speaker for seminar at École Polytechnique Fédérale de Lausanne (EPFL) - "Transcription remodels the composition of the telomeric nucleoprotein" Seminar at École Polytechnique Fédérale de Lausanne (EPFL)
École Polytechnique Fédérale de Lausanne (EPFL) (Lausanne, Switzerland)
2022/05/10 Invited speaker for the Genome Integrity Italian Network (GIIN) seminar series (virtual) - "Telomere transcription in telomerase-negative human cancer cells" Seminar for the Genome Integrity Italian Network (GIIN)
Genome Integrity Italian Network (GIIN), University La Sapienza (Rome (Virtual), Italy)
2022/02/16 Invited speaker for the fourth international course on genome instability and human disease - Institute Curie (virtual) - "Telomere transcription-induced replication stress: a new avenue for curing ALT cancers?" The fourth international course on genome instability and human disease - Institute Curie
Institute Curie (Paris, France)
2022/01/21 Invited speaker for the Genome Maintenance and Cancer (GMaC) Seminar Series (virtual) - "Living on the edge: telomere transcription in telomerase-negative cancer cells" Genome Maintenance and Cancer (GMaC) Seminar Series
Washington University School (United States)
2021/02 Invited speaker for the International Course ‘The Non-Coding Genome’, Institute Curie, Paris, France. The Non-Coding Genome
2019/09 Invited speaker for the ‘RiboClub 20th Anniversary & Canada Gairdner International Symposium’, Orford, Canada.
2019/08 Invited lecturer for the ‘3rd NCCR RNA & Disease summer school’, Saas-Fee, Switzerland.
2019/05 Invited speaker and chairman for the CSHL Meeting ‘Telomeres & Telomerase’, CSH, New York, USA.
2019/01 Invited speaker for the 'VIII National RNA Meeting: ptRNA 2019', i3S, Porto, Portugal.
2018/10 Invited speaker for the EMBO workshop ‘RNA and genome maintenance: Cooperation and conflict management’, Mainz, Germany.
2017/12 Invited speaker for the workshop ‘Telomeres in Health, Aging and Disease’ UNESP Botucatu, Brazil.
2017/10 Invited speaker and chairman for the EMBO meeting ‘Nuclear structure and dynamics’, L’isle-sur-la-Sourge, France.
2017/07 Invited speaker for the GABBA Symposium 'Nano 2 Universe', Porto, Portugal.
2016/07 Invited speaker and chairman for the ‘Congress of Cell Biology - Exploring Cellular Structure and Function’, Prague, Czech Republic.
2016/04 Invited speaker for the EMBO meeting ‘Telomeres, telomerase and disease’, Liege, Belgium.
2015/10 Selected speaker for the ‘Molecular Biology of Ageing Meeting’, Groningen, The Netherlands.
2014/10 Invited speaker for the EMBO workshop ‘Non-coding RNA in genome expression, maintenance and stability’, Cargese, France.
2014/06 Invited speaker for the 7th ‘IMG PhD Conference’, Prague, Czech Republic.
2014/05 Invited speaker for the ‘EMBO Young Scientists Forum 2014’, Brno, Czech Republic.
2013/07 Invited speaker for the 38th FEBS Congress ‘Mechanisms in Biology’, St. Petersburg, Russia.
2013/06 Invited speaker for the Swiss Yeast Meeting, Interlaken, Switzerland.
2013/04 Invited speaker and chairman for the CSHL Meeting ‘Telomeres & Telomerase’, CSH, New York, USA.
2012/12 Invited speaker for the Institute Curie International Course ‘The Non-Coding Genome’, Paris, France.
2012/10 Selected speaker for the EMBO conference ‘Telomeres and the DNA Damage response’, L’isle-sur-la-Sourge, France.
2008/09 Invited speaker and chairman for the EMBO conference ‘Telomeres and the DNA Damage response’, Villars-sur-Ollon, Switzerland.
2007/05 Selected speaker for the CSHL Meeting ‘Telomeres & Telomerase’, CSH, New York, USA.
2003/04 Selected speaker for the CSHL Meeting ‘Telomeres & Telomerase’, CSH, New York, USA.
2002/10 Selected speaker for the CSHL Meeting ‘Molecular genetics of Aging’, CSH New York, USA.

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025/01/01 - Current Characterization of the long noncoding RNA TERRA in zebrafish
Supervisor of Daniel Araújo Sousa Bento
 Engenharia Biomédica e Biofísica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/09/01 - Current Unveiling a novel interaction at human telomeres: the case of the long non-coding RNA TERRA and RAP1
Supervisor of Inês de Freitas Martins
 Master in Biomedical Research (Master)
Instituto de Medicina Molecular, Portugal
2023/01/01 - Current Dissecting the Functions of SUB1 (PC4) in the Alternative Lengthening of Telomeres Pathway (from yeast to human)
Supervisor of Sara Barros Salgado
 PhD in Biomedical Sciences (PhD)
Instituto de Medicina Molecular, Portugal
2022/04/01 - Current Structure and function of the telomeric transcriptome in a vertebrate
Supervisor of Marta Andolfato
 PhD in Biomedical Sciences (PhD)
Instituto de Medicina Molecular, Portugal
2021/02/01 - Current Dissecting the functions of TERRA and TRF proteins across the genome and throughout evolution.
Supervisor of Beatriz Domingues-Silva
 PhD in Biomedical Sciences (PhD)
Instituto de Medicina Molecular, Portugal
2008/01/03 - Current Supervision of 12 Post Doctoral Researchers at ETHZ in Zurich and iMM in Lisbon.
Supervisor
Eidgenössische Technische Hochschule Zürich, Switzerland

Instituto de Medicina Molecular, Portugal
2022/09/01 - 2023/12/05 TERRA-mediated recruitment of SMARCAL1 in response to Telomeric Replication Stress
Supervisor of João Pedro Pina Rebelo
 Master in Molecular Genetics and Biomedicine (Master)
Instituto de Medicina Molecular, Portugal
2022/09/01 - 2023/11/23 Exploring the role of the ESCRT-III proteins in response to telomeric replication stress in ALT cancer cells
Supervisor of Inês Vaz Fernandes Teixeira Justo
 Masters in Biomedical Research (Master)
Instituto de Medicina Molecular, Portugal
2017/03/01 - 2023/03/23 Characterization of the physical and functional interactions between human TRF proteins and the telomeric long noncoding RNA TERRA
Supervisor of Patrícia Lona Abreu
 PhD in Biomedical Sciences (PhD)
Instituto de Medicina Molecular, Portugal
2020/09/01 - 2022/01/04 Exploring the roles of SUB1 in the Alternative Lengthening of Telomeres pathway.
Supervisor of Sara Barros Salgado
 Master in Biochemistry for Health (ITQB) (Master)
Instituto de Medicina Molecular, Portugal
2020/02/01 - 2020/12/31 TERRA transcription profiles in human cancer cells.
Supervisor of Miguel Filipe Martins Louro Alves
Master in Biomedical Engineering (Instituto Superior Técnico, Lisboa) (Master)
Instituto de Medicina Molecular, Portugal
2019/11/02 - 2020/11/27 Novel regulators of telomerase-independent telomere elongation in ALT cancer cells.
Supervisor of Beatriz Pedrosa Moleirinho
 Master in Molecular Biology and Genetics (FCUL) (Master)
Instituto de Medicina Molecular, Portugal
2018/07/01 - 2020/05/31 The roles of telR-Ioops in the stability of telomeres in primary and telomerase-positive cancer cells.
Supervisor of Leonardo Amaro Gaio
 Master in Biopharmaceutical Sciences (FFUL) (Master)
Instituto de Medicina Molecular, Portugal
2014/01/01 - 2018/12/31 FANCM translocase promotes telomere stability and cell viability in ALT (Alternative Lengthening of Telomeres) cells.
Supervisor of Richard Pentz
 Biology (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2013/01/01 - 2016/12/31 TERRA and telomere transcription at the crossroads between telomere length regulation and telomere integrity in Schizosaccharomyces pombe.
Supervisor of Martin Moravec
 Biology (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2013/01/01 - 2016/12/31 Functions of human cactin in pre-mRNA splicing and chromosome stability.
Supervisor of Isabella Martina Yvonne Zanini
 Biology (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2010/01/01 - 2014/12/31 The Mpn1 RNA Exonuclease: Cellular Functions and Implication in Disease.
Supervisor of Vadim Shchepachev
 Biology (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2010/01/01 - 2014/12/31 Cactin family protein Cay1 controls silencing of telomeres and LTR retrotransposons in fission yeast.
Supervisor of Luca Emanuele Lorenzi
 Biology (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2009/01/01 - 2012/12/31 Studying TERRA-associated functions using a human cellular system, in which the transcription of a unique telomere can be induced at will.
Supervisor of Catherine Marie Charlotte Brun
 Biology (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2009/01/01 - 2012/01/01 Characterization of human telomeric repeat-containing RNA biogenesis and function .
Supervisor of Benjamin Oliver Farnung
 Biology (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2008/01/01 - 2011/12/31 Role of human UPF1 in telomere stability processes.
Supervisor of Raghav Chawla
 Biology (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2010/10/01 - 2011/04/30 Characterization of structure and functions of telomeric transcripts in S. pombe.
Supervisor of Lorenzo Lafranchi
 Master in Biological Sciences (Master)
Eidgenössische Technische Hochschule Zürich, Switzerland
2009/09/28 - 2010/03/29 Investigating a potential role of telomere transcription in telomeric chromatic by analysis of subtelomeric gene expression.
Supervisor of Luca Emanuele Lorenzi
 Master in Biological Sciences (Master)
Eidgenössische Technische Hochschule Zürich, Switzerland

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/05/01 - 2024/05/11 I co-organized the EMBO workshop "Telomere function and evolution in health and disease" (held in Rome, ltaly in May 2024). This telomere biology EMBO workshop series is one of the two most important in the telomere biology field together with the one held in Cold Spring Harbor Laboratories (USA). (2024/05/06 - 2024/05/11)
Conference (Co-organisor)
 Instituto de Medicina Molecular, Portugal
2023/01/01 - 2023/10/13 I co-organized the 13th EMBO Young Scientists' Forum, Lisbon, Portugal (October 2023) (2023/10/12 - 2023/10/13)
Conference (Co-organisor)
 Instituto de Medicina Molecular, Portugal
2022/06/01 - 2023/01/27 I co-organized the RNA in Disease - IX ptRNA meeting, Lisbon, Portugal (January 2023) (2023/01/26 - 2023/01/27)
Conference (Co-organisor)
 Instituto de Medicina Molecular, Portugal
2021/09/01 - 2022/10/01 I co-organized the EMBO workshop "Telomere biology in health and human disease", Troia, Portugal (September 2022). This telomere biology EMBO workshop series is one of the two most important in the telomere biology field together with the one held in Cold Spring Harbor Laboratories (USA). (2022/09/26 - 2022/10/01)
Conference (Co-organisor)
 Instituto de Medicina Molecular, Portugal
2017/05/01 - 2018/05/06 I co-organized the EMBO workshop "Telomere biology in health and human disease", Troia, Portugal (May 2018. This telomere biology EMBO workshop series is one of the two most important in the telomere biology field together with the one held in Cold Spring Harbor Laboratories (USA). (2018/05/01 - 2018/05/06)
Conference (Co-organisor)
 Instituto de Medicina Molecular, Portugal
2015/12/01 - 2016/07/31 I co-organized the symposium ‘Non-coding RNAs in health and disease' within the 12th International Congress of Cell Biology, Prague, Czech Republic. (2015/12/01 - 2016/07/31)
Conference (Co-organisor)
 Eidgenössische Technische Hochschule Zürich, Switzerland
2014/06/01 - 2015/01/10 I co-organized the LS2 (Life Science Switzerland) annual meeting ‘Light: from the basis of life to life science technologies’, Zurich, Switzerland. (2014/06/01 - 2015/01/10)
Conference (Co-organisor)
 Eidgenössische Technische Hochschule Zürich, Switzerland

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2008 Since 2008, I have been or still am part of PhD committees of a total of 16 students from different European and American Universities. 16 PhD candidates (PhD)

Association member

Society Organization name Role
2020/06/01 - Current Founding of TessellateBio, a precision oncology company focused on telomere maintenance as a target, Naarden, Netherlands (investors: BioGeneration Ventures - BGV). Co-founder and member of the Board of Directors.
2013/07/01 - Current Associate Membership of ‘Epigenesys’, a FP7 European Community-funded Network of Excellence.
2009/02/28 - 2015/01/31 Faculty member, ETH Zürich. Faculty member

Committee member

Activity description
Role 		Institution / Organization
2022/01/01 - Current Director of the international PhD program LisbonBiomed.
Director
 Instituto de Medicina Molecular, Portugal
2020/01 - Current Board Member of the scientific committee for the PhD program 'Dottorato di Ricerca in Genetica, Biologia Molecolare e Cellulare', University of Pavia, Italy.
Member
 Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie, Italy
2021/12/01 - 2024/09/30 Director of the Advanced Training Hub, Instituto de Medicina Molecular João Lobo Antunes, Lisbon.
Director
 Instituto de Medicina Molecular, Portugal
2019/01/01 - 2021/11/30 Board member, Advanced Training Committee, Instituto de Medicina Molecular João Lobo Antunes, Lisbon.
Member
 Instituto de Medicina Molecular, Portugal
2011/02/01 - 2016/09/30 Board member, PhD Program in Molecular Life Science, ETH Zürich and University of Zürich.
Member
 Eidgenössische Technische Hochschule Zürich, Switzerland

Consulting

Activity description Institution / Organization
2022/11/01 - Current Co-founder, consultant and shareholders of TessellateBIO.

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - Current Advanced Techniques in Biomedical Research II - RNA analysis, Chromosome labelling, Laboratory Rotations Master in Biomedical Research Instituto de Medicina Molecular, Portugal
2021/09 - Current Curso livre experimental - Introdução à investigação científica em biologia molecular da célula (unidade curricular optativa) Integrated Master Degree in Medicine (Mestrado integrado) Instituto de Medicina Molecular, Portugal
2017/01 - Current LisbonBioMed PhD program, Towards a Creative and Critical Mind training module PhD in Biomedical Sciences (Curso de doutoramento (conclusão de unidades curriculares)) Instituto de Medicina Molecular, Portugal
2020/10 - 2022/10 Telomeres and Telomerase: from the discovery to the clinics - Módulo Biologia Molecular, Celular e do Desenvolvimento Humano e Genética Integrated Master in Medicine (Mestrado integrado) Instituto de Medicina Molecular, Portugal
2009 - 2016 I participated in the MLS Cell Biology course for PhD students of ETHZ and University of Zürich. (Doctor of Philosophy) Eidgenössische Technische Hochschule Zürich Institut fur Biochemie, Switzerland

Universität Zürich, Switzerland
2008 - 2016 I organized the block courses: RNA biology, course #: 551-1309-00 (for 3 years); Cause and Consequences of Unstable Genomes, #551-1300-00L (for 1 year) I participated in the following courses: Cellular Biochemistry I #: 551-0319-00, organizer: Prof. Ulrike Kutay; Grundlagen der Biologie I (Praktikum), coordinator: Dr. Ruth Kroschewski; Current Research Topics in Cellular Biochemistry, #: 551-1310-00, organizers: Prof. Vikram Panse and Dr. Alicia Smith; Methods in Cellular Biochemistry Block Course, 551-0336-00, organizer: Prof. Paola Picotti. Courses for Bachelor and Master students at ETHZ Eidgenössische Technische Hochschule Zürich Institut fur Biochemie, Switzerland

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023/05/14 - 2023/05/17 Evaluation Panel Member for the Postgraduate Fellowships abroad 2023, LaCaixa Foundation
Evaluator
 Instituto de Medicina Molecular, Portugal La Caixa Foundation
2018/01/01 - 2018/06/30 Evaluation Panel Member, Agence Nationale de la Recherche (ANR), France.
Evaluator
 Instituto de Medicina Molecular, Portugal Agence nationale de la recherche

Journal scientific committee

Journal title (ISSN) Publisher
2014/05/01 - Current FEBS Letters (1873-3468) Wiley (John Wiley & Sons)

Other jury / evaluation

Activity description Institution / Organization
2008 - Current Manuscript review: Ad hoc reviewer of articles submitted to the journals: The EMBO Journal, EMBO Reports, ELife, Nature, Nature Cell Biology, Nature Structural and Molecular Biology, Scientific Reports, Nature Communications, Nucleic Acids Research, Science, etc.
2008 - Current Reviewer and evaluation panel member for research grant and fellowship applications (Starting, Consolidator and Advanced ERC grants, EMBO, the Swiss Science Foundation, the Swiss Cancer League, , the Agency for Science, Technology and Research of Singapore, etc.
Distinctions

Award

2021 Contract - Estímulo ao Emprego Científico
Fundação para a Ciência e a Tecnologia, Portugal
2012 EMBO Young Investigator Programme (YIP)

Other distinction

2017 EMBO Installation Grant Award
2016 FCT Investigator Programme award
Fundação para a Ciência e a Tecnologia, Portugal
2013 Associate Membership of Epigenesys Network of Excellence
2009 European Research Council (ERC) starting grant BFTERRA
European Research Council, Belgium
2009 Swiss National Science Foundation (SNF) Professorship for Genome Stability
Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Switzerland