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Paula Raposinho has a graduation in Biochemistry (1988, Faculty of Sciences, Univ. of Lisbon) and a PhD in Sciences (Biochemistry) (2002, Faculty of Sciences, Univ. of Geneva, Switzerland) with a thesis on the Neuropeptides and Neuroendocrinology domains. From 1986 until now, she worked on the former Instituto Tecnológico e Nuclear (Bobadela, Portugal), now Instituto Superior Técnico (IST), being actually Assistant Researcher at the Radiopharmaceutical Sciences Group (RSG) from C2TN/IST. Her scientific activity is focused on development and biological characterization of targeted-specific radiopharmaceuticals for Nuclear Medicine, namely metal-based specific probes for molecular imaging (SPECT or PET) and/or therapy of cancer and neurodegenerative diseases. In particular, she is involved in the in vitro and in vivo pre-clinical evaluation of several potential cancer radioprobes based on peptidic or small molecules, beta- and Auger-emitting radiometals and gold nanoparticles. She participates or has participated as a team member in several projects funded by the FCT (8), ANI and industrial partners (e.g. Covidien, ex- Mallinckrodt LLC (USA), Mellacure, Ferring Research Institute Inc). She is the author or co-author of 50 manuscripts in international peer-reviewed journals and supervised 2 MSc dissertations.
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Identification

Personal identification

Full name
Paula Raposinho

Citation names

  • Raposinho, Paula
  • PD Raposinho
  • Raposinho, P

Author identifiers

Ciência ID
9E1A-8B6A-9C11
ORCID iD
0000-0002-9542-1427
Researcher Id
k-3435-2013
Scopus Author Id
8791425700

Email addresses

  • paular@itn.pt (Professional)
  • paular@ctn.tecnico.ulisboa.pt (Professional)

Telephones

Mobile phone
  • 969695853 (Personal)
Telephone
  • 219946225 (Professional)

Addresses

  • Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade Técnica. EstradaNacional 10 (139,7 km), , 2695-066, Bobadela LRS, Loures, Portugal (Professional)
  • Rua Julião Quintinha, 12, 2820-417, Charneca da Caparica, Setúbal, Portugal (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
1997 - 2002/11/22
Concluded
 Sciences (Biochemistry) (Doktor (PhD))
Universidade de Genebra/Universidade de Lisboa (co-tutela), Switzerland
"Potential Role in the Neuroendocrine Regulation of Growth and Reproduction of Various Peptides that are Primarily Involved in the Hypothalamic Control of Feeding and Energy Balance" (THESIS/DISSERTATION)
 6 (in 6)
1982 - 1988
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2002/11/24 - Current Auxiliary Researcher (Research) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
1994/11/24 - 2002/11/24 Research Assistant (Research) Instituto Tecnológico e Nuclear Departamento de Radioisótopos, Portugal
1990/10/24 - 1994/10/12 Research Trainee (Research) Instituto de Ciências e Engenharias Nucleares, Portugal

Others

Category
Host institution 		Employer
1997/10/01 - 2002/11/24 Assistente de Investigação (PhD student) Hopitaux Universitaires de Genève Département de Pédiatrie, Switzerland
1994/10/01 - 1995/10/01 Bolseiro (Confederation of Grants for foreign Students in Switzerland) Confédération Suisse , Switzerland
1986/10/01 - 1990/10/23 Bolseira de Investigação (ICEN) Instituto de Ciências e Engenharias Nucleares, Portugal
Projects

Contract

Designation Funders
2020/01/01 - Current In-beam Time-of-Flight (TOF) Positron Emission Tomography (PET) for proton radiation therapy (LISBOA-01-0247-FEDER-045904)
LISBOA-01-0247-FEDER-045904
Researcher
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2023/12/31 Radiocomplexos Dirigidos a Organelos Celulares para Terapia Auger do Cancro
PTDC/MED-QUI/1554/2020
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Centro de Ciências e Tecnologias Nucleares, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/01 - 2021/08/31 Multifunctional Nanoseeds for Chemoradiotherapy of Glioblastoma -NANOGLIO (PTDC/MED-QUI/29649/2017)
PTDC/MED-QUI/29649/2017
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade da Beira Interior, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/09/01 - 2021 Targeting the transporters of cationic amino acids for cancer radiotheranostics: experimental and computational chemistry approach
PTDC/QUI-NUC/30147/2017
Researcher
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2016/11/30 Molecular and Nano Tools for Cancer Theranostics
EXCL/QEQ-MED/0233/2012
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Aveiro, Portugal

Universidade de Coimbra, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/06/30 Radiolabeling of L-Arginine Analogues with the Unit fac-99mTcCO3+ for Probing Nitric Oxide Synthase NOS in vivo: Synthesis, Characterization and Biological Evaluation
POCI/SAU-FCF/58855/2004
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/10/01 - 2007/12/31 Novel Radioactive Probes for Molecular Imaging of Sigma Receptors
POCI/QUI/59588/2004
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Alves, Susana; Vítor, Rute F.; Raposinho, Paula; Marques, Fernanda; Correia, João D. G.; Paulo, António; Santos, I.. "Metal-based drugs for diagnosis and therapy". In Metal Ions in Biologie and Medicine, edited by Alpoim, M. C; Morais, P. V; Santos, M. A.; Cristovão, A. J.; Centeno, J. A.; Collery, P, 3-8. Paris, France: John Libbey Eurotext, 2006.
    Published
  2. Aubert, M. L.; Sudre, B.; Raposinho, Paula; Vauthay, D.; Pierroz, D. D.; Pralong, F. P.. "Leptin, growth and reproduction". In Brain Somatic Cross-Talk and the Central Control of Metabolism, 121-142. Heidelberg, Germany: Foundation IPSEN, Springer Verlag, 2002.
    Published
  3. Aubert, M. L.; Pierroz, D. D.; Gruaz-Gumowski, N. M.; Sudre-Vuagnat, B.; Raposinho, Paula; Dubuis, J. M.; Broqua, P.; Pralong, F. P.. "Leptin and human reproduction". In Endocrine Basis of Reproductive Function, 279-298. Bologna, Italy: Monduzzi Editore, 2000.
  4. Aubert, M. L.; Pierroz, D. D.; Gruaz-Gumowski, N. M.; Heritier, A.; Sudre-Vuagnat, B.; Pralong, F. P.; Blum, W. F.. "Metabolic and peripheral factors which control reproduction: role of leptin and Neuropeptide Y". In Regulation of Pituitary Hormone Secretion, 165-177. Bristol, United Kingdom: P. Beck-Peccoz Ed, BioScientifica Ltd, 1999.
    Published
Conference abstract
  1. Fernandes, Célia; Santos, Joana F.; M. T. Braz; F. Silva; PD Raposinho; J. F. Guerreiro; F. Cleeren; et al. "Mitochondrion-Tropic Radioconjugates Carrying TPP and PSMA Derivatives: Radiobiological and Imaging Studies in Prostate Cancer Models". Miami, 2022.
    Published
  2. Alice D'Onofrio; Francisco Silva; Raposinho, Paula; Arkadiusz Sikora; Monika Orzelowska; Renata Mikolajczak; Piotr Garnuszek; António Paulo; Gano, Lurdes. "Bioorthogonal Chemistry Approach for Theranostics of GRPR-expressing Cancers". Paper presented in Terachem 2022, Bressanone, 2022.
    Published
  3. PD Raposinho; Francisco Silva; D'Onofrio, Alice; Campello, M.P.C.; C. Oliveira; Belchior, Ana; Fernanda Marujo Marques; António Rocha Paulo. "Radiolabeled Gold Nanoseeds containing Substance P Peptides: Synthesis, Characterization and Evaluation in Glioblastoma Cells". Paper presented in Terachem 2022, Bressanone, 2022.
    Published
  4. Fernandes C ; Joana Filipa Santos; Maria Teresa Braz; Francisco Silva; PD Raposinho; Joana Guerreiro; Frederik Cleeren; et al. "Mitochondria-targeted Radiocomplexes for Cancer Theranostics". Paper presented in Terachem 2022, Bressanone, 2022.
    Published
  5. Figueiredo D; A. Belchior; Fernandes C.; Silva F.; PD Raposinho; Vaz P.; Paulo A.. "Therapy by Auger electrons: 99mTc-labelled Triphenylphosphine and specific for prostate carcinoma". Lisboa, 2019.
    Published
  6. Palma, E.; Mendes, Filipa; Guerreiro J; Campello, M.P.C.; PD Raposinho; Alves V; Abrunhosa, Antero; Paulo A. "New Cu-ATSM and Cu-GTSM Derivatives for Cancer Theranostics". Paper presented in NOVA BIOPHYSICA International Congress, Lisboa, 2019.
    Published
  7. Paulo A; Fernandes, Célia; Palma, E.; Mendes, Filipa; do Quental, Letícia; PD Raposinho; Ana Bechior; P Vaz; Salvatori di Maria. "Radiobiological andDosimetric Assessment of DNA-Targeted 99mTc(I) Complexes". Lisboa, 2019.
    Published
Conference paper
  1. Morais, Mauricio; Raposinho, Paula; C. Oliveira; Correia, João D. G.; Santos, I. "Novel 99mTc(CO)3-Labeled Cyclic a-MSH Analogs, Peptides: Building Bridges". Paper presented in 22nd American Peptide Symposium, San Diego, 2011.
    Published
  2. Correia, João D. G.; Morais, Mauricio; PD Raposinho; C. Oliveira; Santos, I. "Homobivalent alpha-MSH Analogs Labeled with fac-[99mTc(CO)3]+ for Targeting MC1R in vivo". Paper presented in 22nd American Peptide Symposium, San Diego, 2011.
    Published
  3. Antunes, P; PD Raposinho; Esteves, T.; Santos, I.. "Radiolabelled Short Neuropeptide Y Derivatives with Bifunctional Chelators for Breast Cancer". Paper presented in International Symposium on Technetium and other Radiometals in Chemistry and Medicine (TERACHEM 2010), Bressanone, 2010.
    Published
  4. Moura, C.; Gano, L.; PD Raposinho; Paulo, A.; Abrantes, A.M.; Botelho, M.F.; Santos, I.. "Technetium(I)-99m Tricarbonyl complexes for targeting melanotic melanoma". Paper presented in International Symposium on Technetium and other Radiometals in Chemistry and Medicine (TERACHEM 2010), Bressanone, 2010.
    Published
  5. Morais, M.; Raposinho, P; C. Oliveira; Correia, JDG; Santos, I.. "99mTc(CO)3-Labeling and Biological Evaluation". Paper presented in 31st European Peptide Symposium, Copenhagen, 2010.
    Published
  6. Can, D.; H.P. N´Dongo; P. Schmutz; R. Alberto; PD Raposinho; I. Santos. "[CpTc(CO)3] replacing phenyl rings in bioactive molecules for radiopharmaceuticals". Paper presented in International Symposium on Technetium and other Radiometals in Chemistry and Medicine (TERACHEM 2010), Bressanone, 2010.
    Published
Conference poster
  1. Mendes, Filipa; Fernandes, Célia; Santos, Joana F.; Braz, Maria Teresa ; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F; Paulo, António. "Dual-targeted 111In and 161Tb Complexes for Radionuclide Therapy of Prostate Cancer". 2023.
  2. Fernandes, Célia; Santos, Joana; Braz, Maria Teresa ; Silva, Francisco; PD Raposinho; Guerreiro, Joana F.; Frederik Cleeren; Paulo, António. "Mitochondria-targeted Radiocomplexes for Cancer Theranostics". 2022.
Journal article
  1. Joana F. Santos; Maria T. Braz; Paula Raposinho; Frederik Cleeren; Irwin Cassells; Simon Leekens; Christopher Cawthorne; et al. "Synthesis and Preclinical Evaluation of PSMA-Targeted 111In-Radioconjugates Containing a Mitochondria-Tropic Triphenylphosphonium Carrier". Molecular Pharmaceutics 21 1 (2024): 216-233. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00787.
    Published • 10.1021/acs.molpharmaceut.3c00787
  2. Federica Battistin; Célia Fernandes; Paula. D. Raposinho; Olivier Blacque; António Paulo; Roger Alberto. "In vivo and in vitro studies of [M(¿6-pseudoerlotinib)]+ sandwich complexes (M = Re, 99mTc)". Dalton Transactions 52 43 (2023): 15757-15766. http://dx.doi.org/10.1039/d3dt03011c.
    Published • 10.1039/d3dt03011c
  3. Alice D’Onofrio; Francisco Silva; Lurdes Gano; Paula Raposinho; Célia Fernandes; Arkadiusz Sikora; Monika Wyczólkowska; et al. "Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14122569.
    10.3390/pharmaceutics14122569
  4. Célia Fernandes; Elisa Palma; Francisco Silva; Ana Belchior; Catarina I. G. Pinto; Joana F. Guerreiro; Hugo M. Botelho; et al. "Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23137238.
    10.3390/ijms23137238
  5. Francisco Silva; Alice D’Onofrio; Carolina Mendes; Catarina Pinto; Ana Marques; Maria Paula Cabral Campello; Maria Cristina Oliveira; et al. "Radiolabeled Gold Nanoseeds Decorated with Substance P Peptides: Synthesis, Characterization and In Vitro Evaluation in Glioblastoma Cellular Models". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23020617.
    10.3390/ijms23020617
  6. Raposinho, Paula. "Synthesis and Biological Evaluation of 99mTc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria". Molecules (2021): https://www.mdpi.com/1420-3049/26/2/441.
    10.3390/molecules26020441
  7. Raposinho, Paula. "Radiobiological and dosimetric assessment of DNA-intercalated 99m Tc-complexes bearing acridine orange derivatives". (2020): https://ejnmmires.springeropen.com/articles/10.1186/s13550-020-00663-9.
    10.1186/s13550-020-00663-9
  8. Pino-Cuevas, Arantxa; Raposinho, Paula D; Fernandes, Célia; Paulo, António; Abram, Ulrich; Carballo, Rosa; Vázquez-López, Ezequiel M. "Thiosemicarbazonate complexes with affinity for amyloid-ß fibers: synthesis, characterization and biological studies". Future Medicinal Chemistry 11 19 (2019): 2527-2546. http://dx.doi.org/10.4155/fmc-2019-0013.
    10.4155/fmc-2019-0013
  9. Palma, Elisa; Botelho, Hugo M.; Morais, Goreti Ribeiro; Rodrigues, Inês; Santos, Isabel Cordeiro; Campello, Maria Paula Cabral; Raposinho, Paula; et al. "Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies". JBIC Journal of Biological Inorganic Chemistry 24 1 (2018): 71-89. http://dx.doi.org/10.1007/s00775-018-1629-6.
    10.1007/s00775-018-1629-6
  10. Gabano, Elisabetta; do Quental, Letícia; Perin, Elena; Silva, Francisco; Raposinho, Paula; Paulo, António; Ravera, Mauro. "Pt(IV)/Re(I) Chitosan Conjugates as a Flexible Platform for the Transport of Therapeutic and/or Diagnostic Anticancer Agents". Inorganics 6 1 (2017): 4. http://dx.doi.org/10.3390/inorganics6010004.
    10.3390/inorganics6010004
  11. Raposinho, Paula. "NMR Insights into the Structure-Function Relationships in the Binding of Melanocortin Analogues to the MC1R Receptor.". Molecules (Basel, Switzerland) (2017): http://europepmc.org/abstract/med/28714883.
    10.3390/molecules22071189
  12. Raposinho, Paula. "Combining imaging and anticancer properties with new heterobimetallic Pt(ii)/M(i) (M = Re, 99mTc) complexes.". Dalton transactions (Cambridge, England : 2003) (2017): http://europepmc.org/abstract/med/28164201.
    10.1039/c7dt00043j
  13. Raposinho, Paula. "Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes.". Journal of inorganic biochemistry (2017): http://europepmc.org/abstract/med/27907865.
    10.1016/j.jinorgbio.2016.11.026
  14. Raposinho, Paula. "Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA.". Scientific Reports (2017): http://europepmc.org/abstract/med/28211920.
    10.1038/srep42544
  15. Maurício Morais; Vera F. C. Ferreira; Flávio Figueira; Filipa Mendes; Paula Raposinho; Isabel Santos; Bruno L. Oliveira; João D. G. Correia. "Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters". Dalton Transactions 46 42 (2017): 14537-14547. https://doi.org/10.1039/C7DT01146F.
    10.1039/C7DT01146F
  16. Raposinho, Paula. "Towards (99m)Tc-based imaging agents with effective doxorubicin mimetics: a molecular and cellular study.". Dalton transactions (Cambridge, England : 2003) (2016): http://europepmc.org/abstract/med/27097328.
    10.1039/c6dt00871b
  17. Raposinho, Paula. "Nuclear Targeting with an Auger Electron Emitter Potentiates the Action of a Widely Used Antineoplastic Drug.". Bioconjugate chemistry (2015): http://europepmc.org/abstract/med/26473388.
    10.1021/acs.bioconjchem.5b00466
  18. Morais, M.; Oliveira, B.L.; Correia, J.D.G.; Oliveira, M.C.; Jiménez, M.A.; Santos, I.; Raposinho, P.D.. "Influence of the bifunctional chelator on the pharmacokinetic properties of 99mTc(CO)3-labeled cyclic a-melanocyte stimulating hormone analog". Journal of Medicinal Chemistry 56 5 (2013): 1961-1973. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875123861&partnerID=MN8TOARS.
    10.1021/jm301647t
  19. Moura, C.; Gano, L.; Mendes, F.; Raposinho, P.D.; Abrantes, A.M.; Botelho, M.F.; Santos, I.; Paulo, A.. "99mTc(I)/Re(I) tricarbonyl complexes for in vivo targeting of melanotic melanoma: Synthesis and biological evaluation". European Journal of Medicinal Chemistry 50 (2012): 350-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858449323&partnerID=MN8TOARS.
    10.1016/j.ejmech.2012.02.014
  20. Morais, M.; Raposinho, P.D.; Oliveira, M.C.; Correia, J.D.G.; Santos, I.. "Evaluation of novel 99mTc(I)-labeled homobivalent a-melanocyte-stimulating hormone analogs for melanocortin-1 receptor targeting". Journal of Biological Inorganic Chemistry 17 4 (2012): 491-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862538361&partnerID=MN8TOARS.
    10.1007/s00775-011-0871-y
  21. Can, Daniel; Spingler, Bernhard; Schmutz, Paul; Mendes, Filipa; Raposinho, Paula; Fernandes, Celia; Carta, Fabrizio; et al. "(Cp-R)M(CO)3 (M=Re or 99mTc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX". Angewandte Chemie-International Edition 51 14 (2012): 3354-3357.
    10.1002/anie.201107333
  22. Can, D.; Peindy N'Dongo, H.W.; Spingler, B.; Schmutz, P.; Raposinho, P.; Santos, I.; Alberto, R.. "The [(Cp)M(CO)3] (M=Re, 99mTc) building block for imaging agents and bioinorganic probes: Perspectives and limitations". Chemistry and Biodiversity 9 9 (2012): 1849-1866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866353928&partnerID=MN8TOARS.
    10.1002/cbdv.201200076
  23. Morais, M.; Raposinho, P.D.; Oliveira, M.C.; Pantoja-Uceda, D.; Jiménez, M.A.; Santos, I.; Correia, J.D.G.. "NMR structural analysis of MC1R-targeted rhenium(I) metallopeptides and biological evaluation of 99mTc(I) congeners". Organometallics 31 16 (2012): 5929-5939. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865486287&partnerID=MN8TOARS.
    10.1021/om300502n
  24. Correia, J.D.G.; Paulo, A.; Raposinho, P.D.; Santos, I.. "Radiometallated peptides for molecular imaging and targeted therapy". Dalton Transactions 40 23 (2011): 6144-6167. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958191536&partnerID=MN8TOARS.
    10.1039/c0dt01599g
  25. Oliveira, B.L.; Raposinho, P.D.; Mendes, F.; Santos, I.C.; Santoes, I.; Ferreira, A.; Cordeiro, C.; Freire, A.P.; Correia, J.D.G.. "Targeting nitric oxide synthase with 99mTc/Re-tricarbonyl complexes containing pendant guanidino or isothiourea moieties". Journal of Organometallic Chemistry 696 5 (2011): 1057-1065. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952194212&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2010.09.019
  26. Morais, Mauricio; Raposinho, P. D.; Oliveira, M. C.; Correia, J. D. G.; Santos, I.. "Tc-99m(1)-Cyclic alpha-MSH Analogs for MC1R Targeting". Biopolymers 96 4 (2011): 515-515.
  27. Oliveira, B.L.; Raposinho, P.D.; Mendes, F.; Figueira, F.; Santos, I.; Ferreira, A.; Cordeiro, C.; Freire, A.P.; Correia, J.D.G.. "Re and Tc tricarbonyl complexes: From the suppression of NO biosynthesis in macrophages to in vivo targeting of inducible nitric oxide synthase". Bioconjugate Chemistry 21 12 (2010): 2168-2172. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650341241&partnerID=MN8TOARS.
    10.1021/bc100291e
  28. Raposinho, P.D.; Correia, J.D.; Oliveira, M.C.; Santos, I.; Raposinho, Paula. "Melanocortin-1 receptor-targeting with radiolabeled cyclic a-melanocyte-stimulating hormone analogs for melanoma imaging.". Biopolymers 94 6 (2010): 820-829. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952687086&partnerID=MN8TOARS.
    10.1002/bip.21490
  29. Moura, C.; Esteves, T.; Gano, L.; Raposinho, P.D.; Paulo, A.; Santos, I.. "Synthesis, characterization and biological evaluation of tricarbonyl M(i) (M = Re, 99mTc) complexes functionalized with melanin-binding pharmacophores". New Journal of Chemistry 34 11 (2010): 2564-2578. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049263952&partnerID=MN8TOARS.
    10.1039/c0nj00256a
  30. Silva, Francisco; Morais, Mauricio; Raposinho, Paula D.; Paula, M.; Carvell, C.; Correia, Joao D. G.; Paulo, Antonio; Santos, Isabel. "PEGylated DOTA-alpha-MSH analogues for in vivo targeting of melanoma". Nuclear Medicine and Biology 37 6 (2010): 694-694.
    10.1016/j.nucmedbio.2010.04.124
  31. Morais, M. M.; Raposinho, P. D.; Correia, J. D. G.; Santos, I.. "Homobivalent a-MSH derivatives for Melanoma Imaging: 99mTc(CO)3-Labeling and Biological Evaluation". Journal of Peptide Science 16 (2010): 186-186.
  32. Esteves, T.; Xavier, C.; Gama, S.; Mendes, F.; Raposinho, P.D.; Marques, F.; Paulo, A.; et al. "Tricarbonyl M(I) (M = Re, 99mTc) complexes bearing acridine fluorophores: Synthesis, characterization, DNA interaction studies and nuclear targeting". Organic and Biomolecular Chemistry 8 18 (2010): 4104-4116. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955948795&partnerID=MN8TOARS.
    10.1039/c0ob00073f
  33. Peindy N'Dongo, H.W.; Raposinho, P.D.; Fernandes, C.; Santos, I.; Can, D.; Schmutz, P.; Spingler, B.; Alberto, R.. "Preparation and biological evaluation of cyclopentadienyl-based 99mTc-complexes [(Cp-R)99mTc(CO)3] mimicking benzamides for malignant melanoma targeting". Nuclear Medicine and Biology 37 3 (2010): 255-264. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950298117&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2009.11.006
  34. Vitor, R.F.; Esteves, T.; Marques, F.; Raposinho, P.; Paulo, A.; Rodrigues, S.; Rueff, J.; et al. "99mTc-Tricarbonyl Complexes Functionalized with Anthracenyl Fragments: Synthesis, Characterization, and Evaluation of Their Radiotoxic Effects in Murine Melanoma Cells". Cancer Biotherapy and Radiopharmaceuticals 24 5 (2009): 551-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449113426&partnerID=MN8TOARS.
    10.1089/cbr.2009.0647
  35. Oliveira, B.L.; Correia, J.D.G.; Raposinho, P.D.; Santos, I.; Ferreira, A.; Cordeiro, C.; Freire, A.P.. "Re and 99mTc organometallic complexes containing pendant l-arginine derivatives as potential probes of inducible nitric oxide synthase". Dalton Transactions 1 (2009): 152-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649133265&partnerID=MN8TOARS.
    10.1039/b805986a
  36. Valldosera, M.; Monsò, M.; Xavier, C.; Raposinho, P.; Correia, J.D.G.; Santos, I.; Gomes, P.. "Comparative Study of Chemical Approaches to the Solid-Phase Synthesis of a Tumor-Seeking a-MSH Analogue". International Journal of Peptide Research and Therapeutics (2008): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-49849090700&partnerID=MN8TOARS.
    10.1007/s10989-008-9143-2
  37. Raposinho, P.D.; Correia, J.D.G.; Alves, S.; Botelho, M.F.; Santos, A.C.; Santos, I.. "A 99mTc(CO)3-labeled pyrazolyl-a-melanocyte-stimulating hormone analog conjugate for melanoma targeting". Nuclear Medicine and Biology 35 1 (2008): 91-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-37449007128&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2007.08.001
  38. Palma, E.; Oliveira, B.L.; Figueira, F.; Correia, J.D.G.; Raposinho, P.D.; Santos, I.. "A pyrazolylamine-phosphonate monoester chelator for the fac-[M(CO) 3]+ core (M = Re, 99mTc): Synthesis, coordination properties and biological assessment". Journal of Labelled Compounds and Radiopharmaceuticals 50 13 (2007): 1176-1184. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949087577&partnerID=MN8TOARS.
    10.1002/jlcr.1415
  39. Raposinho, P.D.; Pedrazzini, T.; White, R.B.; Palmiter, R.D.; Aubert, M.L.. "Chronic Neuropeptide Y Infusion into the Lateral Ventricle Induces Sustained Feeding and Obesity in Mice Lacking Either Npy1r or Npy5r Expression". Endocrinology 145 1 (2004): 304-310. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346458786&partnerID=MN8TOARS.
    10.1210/en.2003-0914
  40. Raposinho, P.D.; White, R.B.; Aubert, M.L.. "The Melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat". Journal of Neuroendocrinology 15 2 (2003): 173-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037320466&partnerID=MN8TOARS.
    10.1046/j.1365-2826.2003.00962.x
  41. Pralong, F.P.; Castillo, E.; Raposinho, P.D.; Aubert, M.L.; Gaillard, R.C.; Raposinho, Paula. "Obesity and the reproductive axis". Annales d'Endocrinologie 63 2 I (2002): 129-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036109531&partnerID=MN8TOARS.
  42. Raposinho, P.D.; Pierroz, D.D.; Broqua, P.; White, R.B.; Pedrazzini, T.; Aubert, M.L.. "Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism". Molecular and Cellular Endocrinology 185 1-2 (2001): 195-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035924078&partnerID=MN8TOARS.
    10.1016/S0303-7207(01)00620-7
  43. Raposinho, P.D.; Castillo, E.; D'Alleves, V.; Broqua, P.; Pralong, F.P.; Aubert, M.L.. "Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes". Endocrinology 141 12 (2000): 4419-4427. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034527518&partnerID=MN8TOARS.
    10.1210/en.141.12.4419
  44. Raposinho, P.D.; Broqua, P.; Hayward, A.; Akinsanya, K.; Galyean, R.; Schteingart, C.; Junien, J.-L.; Aubert, M.L.; Raposinho, Paula. "Stimulation of the gonadotropic axis by the neuropeptide Y receptor Y1 antagonist/Y4 agonist 1229U91 in the male rat". Neuroendocrinology 71 1 (2000): 2-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033970517&partnerID=MN8TOARS.
    10.1159/000054514
  45. Raposinho, P.D.; Broqua, P.; Pierroz, D.D.; Hayward, A.; Dumont, Y.; Quirion, R.; Junien, J.-L.; Aubert, M.L.; Raposinho, Paula. "Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype". Endocrinology 140 9 (1999): 4046-4055. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033305479&partnerID=MN8TOARS.
    10.1210/endo.140.9.6985
  46. Raposinho, P.D.; Pierroz, D.D.; Sizonenko, P.C.; Aubert, M.L.. "P-096. pulsatile release of growth hormone is inhibited by acute i.c.v. administration of npy y1 agonists in the rat". Endocrinology and Metabolism, Supplement 4 A (1997): 72-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747712002&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Antunes, Marta Sofia de Oliveira. "Análogos do neuropéptido Y marcados com 99mTc para detecção de receptores Y1 expressos no cancro da mama". Master, 2012. http://hdl.handle.net/10400.21/2312.
  2. "Potential Role in the Neuroendocrine Regulation of Growth and Reproduction of Various Peptides that are Primarily Involved in the Hypothalamic Control of Feeding and Energy Balance". PhD, Universidade de Genebra/Universidade de Lisboa (co-tutela), 2002.
  3. "Doseamento Radioimunológico de Hormonas Tiroideias: Métodos de Separação". Master, Instituto Tecnológico e Nuclear Departamento de Radioisótopos, 1994.
  4. "Desenvolvimento de um método de doseamento do cortisol, por radioimunoensaio". Degree, Universidade de Lisboa Faculdade de Ciências, 1988.

Other

Other output
  1. Tricarbonyl M(I) (M = Re, 99mTc) complexes bearing acridine fluorophores : synthesis, characterization, DNA interaction studies and nuclear targeting. New pyrazolyl-diamine ligands with acridine derivatives at the 4-position of the pyrazolyl ring were synthesized and characterized (L1 and L2). Coordination towards the fac-[M(CO)3]+ (M = Re, 99mTc) led to complexes fac-[M(CO)3(¿3-L)] (L = L1: M = Re1, Tc1; L = L2: M = Re2, Tc2). The interaction of the novel pyrazolyl-diamine ligands (L1 and L2) and rhenium(I) complexes (Re1 and Re2) with calf thy. 2010. Esteves, Teresa; Xavier, Catarina; Gama, Sofia; Mendes, Filipa; Raposinho, Paula D.; Marques, Fernanda; Paulo, António; et al. http://dx.doi.org/10.1039/C0OB00073F.
    http://dx.doi.org/10.1039/C0OB00073F
  2. Melanoma targeting with alpha-melanocyte stimulating hormone analogs labeled with fac-[Tc-99m(CO)(3)](+): effect of cyclization on tumor-seeking properties. Early detection of primary melanoma tumors is essential because there is no effective treatment for metastatic melanoma. Several linear and cyclic radiolabeled alpha-melanocyte stimulating hormone (alpha-MSH) analogs have been proposed to target the melanocortin type 1 receptor (MC1R) overexpressed in melanoma. The compact structure of a rhenium-cyclized alpha-MSH analog (Re-CCMSH) significantly e. 2008. Faculdade de Ciências. 0949-8257.
    10.1007/s00775-007-0338-3
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/03/14 Cellular Studies of 67Ga/177Lu-Labeled Nanoparticles for the Theranostics of Glioblastoma
IWRMR (London)
2023/03/14 Challenges in Radiation Biology: from the radiation’ nano-scopic pattern to biological effectiveness The 2nd International Workshop on Radiobiology of Molecular Radionuclide Therapy (IWRMR)
IWRMR (London, United Kingdom)
2022/09/17 Radiolabeled Gold Nanoseeds containing Substance P Peptides: Synthesis, Characterization and Evaluation in Glioblastoma Cells Terachem 2022
Society of Radiopharmaceutical Sciences (Bressanone, Italy)
2017/11/24 Experimentação Animal Seminars for 4th year of Nuclear Medicine graduation
Escola Superior de Tecnologia da Saúde de Lisboa (Lisboa, Portugal)
2017/09/27 Acridine-Orange derivates as DNA-targeted radiopharmaceuticals for Auger therapy Proteção Radiológica na Saúde 2017 (PRS2017)
Instituto Superior Técnico (CTN) (Bobadela, Portugal)
2016/02/15 Radiolabeled Acridine Orange (AO) Derivatives as DNA-Targeted Probes for Auger Therapy
(Geneva, Switzerland)
2016 Experimentação Animal
Escola Superior de Tecnologia da Saúde de Lisboa (Lisboa, Portugal)
2015/11/06 Experimentação Animal Seminars for 4th year of Nuclear Medicine graduation
Escola Superior de Tecnologia da Saúde de Lisboa (Lisboa, Portugal)
2014/11/28 Experimentação Animal Seminars for 4th year of Nuclear Medicine graduation
Escola Superior de Tecnologia da Saúde de Lisboa (Lisboa, Portugal)
2014/05/05 In vitro evaluation of radiopeptides (lecture in Module 10 (Biological assessment of peptides))
Instituto Superior Técnico (C2TN) (Lisboa, Portugal)
2012/08/20 Experimentação Animal (thematic panel of “Ética e Deontologia”) Seminars for 4th year of ESTeSL graduations
Escola Superior de Tecnologia da Saúde de Lisboa (Lisboa, Portugal)
2009/10/26 Cyclic MC1 receptor-targeting peptides labeled with 99mTc for melanoma imaging.
IRB Barcelona (Barcelona, Spain)
2007 A novel 99mTc(CO)3-labeled lactam-based cyclized ¿-MSH analog for melanoma targeting
Sociedade Portuguesa de Medicina Nuclear (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - Current Subcellular Targeted Radiopharmaceuticals to Unravel the Potential of Auger-Electron Cancer Therapy
Co-supervisor
 Engenharia Biomédica (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023 - 2024/01/15 Radiocomplexes for Prostate Cancer Theranostics (Integrated 1st Cycle Project in Biological Engineering (PI-1CPJ))
Co-supervisor
 Engenharia Biomédica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02/23 - 2023/06 Biological evaluation of multifunctional radiocompounds for prostate cancer imaging and therapy (Integrated 1st Cycle Project in Biological Engineering (P17))
Supervisor
 Engenharia Biológica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/10/20 - 2021/12/21 Dual-Targeted 99mTc-Radioconjugates for Prostate Cancer Theranostics
Co-supervisor
 Universidade de Lisboa Instituto Superior Técnico-Mestrado de Proteção e Segurança Radiológica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016/06/22 Novos Complexos de Cu(II) para aplicações teranósticas (UC: Estágios em Medicina Nuclear III)
Supervisor
 Medicina Nuclear (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2015 - 2015/07/01 Novos complexos de Cu(II) e trans-Platina (aplicações em oncologia) (UC: Estágios em Medicina Nuclear III)
Supervisor
 Medicina Nuclear (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2014 - 2014/06/16 Radiotoxicidade de emissores de electrões Auger: 99mTc-complexos de intercaladores do DNA e de análogos de doxorrubicina em células tumorais (UC: Estágios em Medicina Nuclear III)
Supervisor
 Medicina Nuclear (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2014/03/23 - 2014/04/12 Training on 99mTc radiolabeling and in vitro biological characterization (cellular uptake and radiotoxicity) of Doxorubicine derivatives (STSM on COST Action CM1105: Functional metal complexes that bind to biomolecules)
Co-supervisor
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2013/09 - 2013/12 Training on Synthesis and 99mTc-labeling of cyclic a-MSH analogs (Research fellowship - IAEA grant)
Co-supervisor
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2013/03/11 - 2013/03/22 Training on 99mTc radiolabeling and in vitro characterization of glucose derivatives (STSM on COST Action CM1105: Functional metal complexes that bind to biomolecules)
Supervisor
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2012 - 2012 Análogos de Neuropéptido Y marcados com 99mTc para deteção de recetores Y1 expressos no cancro da mama Medicina Nuclear (Master)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011 - 2011/06/17 Radiopéptidos, análogos da a-MSH, específicos para o receptor MC1 sobreexpresso no melanoma: optimização da farmacocinética (UC: Estágios em Medicina Nuclear III)
Supervisor
 Medicina Nuclear (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011 - 2011/06/17 Radiomarcação de péptidos análogos do Neuropéptido Y para diagnóstico do cancro da mama (UC: Estágios em Medicina Nuclear III)
Supervisor
 Medicina Nuclear (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011/05/08 - 2011/05/16 Radiolabeling and biological evaluation of Carbonic anhydrase IX (CAIX) inhibitors in HT29 human colorectal tumor xenografts (research fellowship - colaboration Grupo de Ciências Radiofarmacêuticas do ITN/ Medicinal Inorganic Chemistry Group, Institute of Inorganic Chemistry)
Supervisor
Instituto Tecnológico e Nuclear Departamento de Radioisótopos, Portugal
2010 - 2011/01 Péptidos análogos da bombesina no diagnóstico e terapia do adenocarcinoma da prostata (UC: Estágios em Medicina Nuclear II)
Supervisor
 Medicina Nuclear (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2010 - 2011/01 Análogos da alpha-MSH para o diagnóstico e terapia do melanoma (UC: Estágios em Medicina Nuclear II)
Supervisor
 Medicina Nuclear (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2009/04 - 2009/04 Biological evaluation of cyclopentadienyl based 99mTc-complexes[(Cp-R)99mTc(CO)3] mimicking benzamides for malignant melanoma targeting (research fellowship - colaboration Grupo de Ciências Radiofarmacêuticas do ITN/ Medicinal Inorganic Chemistry Group, Institute of Inorganic Chemistry, University of Zurich)
Supervisor
Instituto Tecnológico e Nuclear Departamento de Radioisótopos, Portugal
2005/06 - 2005/06 In vitro and in vivo evaluation of 99mTc(CO)3-complexes based on the [2+1] approach (research felhowship -collaboration of Grupo de Ciências Radiofarmacêuticas do ITN/ Medicinal Inorganic Chemistry Group, Institute of Inorganic Chemistry, University of Zurich)
Supervisor
Instituto Tecnológico e Nuclear Departamento de Radioisótopos, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12/21 Dual-Targeted 99mTc-Radiocomplexes for Prostate Cancer Theranostics
(Thesis) Arguer
 Diogo Loureiro Figueiredo (Master)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021/12/07 Dual-Targeted Radiocomplexes for Prostate Cancer Theranostics
(Thesis) Arguer
 Ana Rita Mosquito Julião (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/12/06 PC3 cell line – a study on induction of damages and repair kinetics
(Thesis) Main arguer
 Filipe Fernandes Pires (Master)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2014/10/20 Multifunctional organometallic compounds for Auger Therapy
(Thesis) Main arguer
 Annica de Barros Rosa (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/06/11 Análogos do Neuropéptido Y marcados com 67Ga para Imagiologia Molecular dos Recetores Y1 no Cancro da Mama
(Thesis) Main arguer
 Isabel Sofia Caldeira Rodrigues (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/06/11 Análogos do Neuropéptido Y marcados com 67Ga para Imagiologia Molecular dos Recetores Y1 no Cancro da Mama
(Thesis) Arguer
 Isabel Sofia Caldeira Rodrigues (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal