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Bárbara Gomes Patrício concluiu a Licenciatura em Bioquímica (2015) e o Mestrado em Bioquímica (2017) pela Faculdade de Ciências da Universidade do Porto e pelo Instituto de Ciências Biomédicas Abel Salazar. Durante este período, desenvolveu trabalhos de investigação nas áreas da química orgânica, síntese de péptidos e sua aplicação na área do cancro, papel do nervo vago na secreção de hormonas gastrointestinais e morfologia pancreática, e perfil de secreção de hormonas gastrointestinais em cirurgia bariátrica no contexto da diabetes e obesidade. Este percurso incluiu um intercâmbio Erasmus+ na Faculdade de Ciências Médicas da Universidade de Copenhaga durante a tese de mestrado entitulada "Comparison of the mixed-meal stimulated gut hormone secretion profile after classical gastric bypass and the long biliopancreatic limb variant". Mais tarde, doutorou-se em Medicina Translacional (2021) pela Scuola Superiore Sant'Anna, em Pisa, Itália, no âmbito do projeto European Training Network FOIE GRAS: Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD), mais especificamente ESR 6 - "Glucagon-like peptide-1 (GLP-1) as a key player in the gut-liver axis: role in non-alcoholic fatty liver disease (NAFLD)", financiado pelas Ações Marie Sklodowska-Curie - Horizonte 2020 (grant agreement No. 722619). Este projeto foi desenvolvido no Consiglio Nazionale delle Ricerche - Area di Pisa, com um intercâmbio na NOVA Medical School - Centro de Estudos de Doenças Crónicas (CEDOC), e envolveu análises metabolómicas e fluxómicas de amostras de pacientes NAFLD usando isótopos estáveis, avaliação dos efeitos do tratamento com agonistas do recetor de GLP-1 em pacientes com NAFLD, e impacto da permeabilidade intestinal na progressão da NAFLD em modelos animais através da quantificação de proteínas de junções de oclusão no instetino e fígado. Publicou 9 artigos em revistas especializadas e recebeu o prémio nacional da Sociedade Portuguesa de Diabetes em 2017 com o trabalho: "Could surgical treatment be customized to achieve the desired metabolic response in type 2 diabetes?". Atua nas áreas das Ciências Biológicas com ênfase em Bioquímica e Ciências Médicas e da Saúde com ênfase em Endocrinologia e Metabolismo. De momento, é Innovation Program Manager - Health&Pharma no Data CoLAB, onde desenvolve atividades de gestão de projetos em saúde, criação de parcerias e escrita de projetos financiados.
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Identification

Personal identification

Full name
Bárbara Gomes Patrício

Citation names

  • Patrício, Bárbara G

Author identifiers

Ciência ID
9D1B-D691-4EE0
ORCID iD
0000-0002-2418-4540

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Italian Intermediate (B1) Elementary (A2) Elementary (A2) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2017/10 - 2021/10
Concluded
 Translational Medicine (Dottorato di Ricerca)
Major in Systems Physiology and Pathophysiology, Experimental and Clinical
Scuola Superiore Sant'Anna, Italy
"Importance of the Gut-Liver Axis on Lipid Metabolism: Implications in the Pathogenesis of Obesity-Related Non-Alcoholic Fatty Liver Disease" (THESIS/DISSERTATION)
2017/07
Concluded
 Bioquímica (Mestrado)
Major in Sem especialização
Universidade do Porto Faculdade de Ciências, Portugal
"Comparison of the mixed-meal stimulated gut hormone secretion profile after classical gastric bypass and the long biliopancreatic limb variant." (THESIS/DISSERTATION)
 20
2011/09 - 2015/09
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Evaluation of GPL-1 effects on pancreatic morphology" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2017/09/01 - 2021/01/31 Researcher (Research) Consiglio Nazionale delle Ricerche Area della Ricerca di Pisa, Italy
2019/04 - 2019/12 Visiting Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016/02 - 2017/07 Research Trainee (Research) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/07 - 2016/11 Visiting Researcher (Research) Københavns Universitet Det Sundhedsvidenskabelige Fakultet, Denmark
2016/02/01 - 2016/07/31 Research Trainee (Research) Universidade do Porto Faculdade de Ciências, Portugal
2014/09 - 2015/09 Research Trainee (Research) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/07 - 2014/08 Research Trainee (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge Porto, Portugal
2014/02 - 2014/07 Research Trainee (Research) Universidade do Porto Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2022/11/01 - Current Innovation Program Manager - Health&Pharma Data CoLAB, Portugal
2021/07/01 - 2022/04/11 Business Developer FairJourney Biologics SA, Portugal
2021/04/01 - 2021/06/30 Analyst Deloitte Portugal, Portugal
Projects

Grant

Designation Funders
2017/09/01 - 2021/01/31 Importance of the gut-liver axis in NAFLD: GLP-1 as a key player
722619
PhD Student Fellow
Consiglio Nazionale delle Ricerche Area della Ricerca di Pisa, Italy
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded

Contract

Designation Funders
2018/10/01 - 2021/09/30 Estratificação de doenças metabólicas crónicas: exossomas derivados de eixo hepático-intestinal.
PTDC/MEC-MET/29314/2017
Universidade de Aveiro, Portugal

Universidade Nova de Lisboa, Portugal

Fundação Champalimaud, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Morais, Tiago; Seabra, Alexandre; Patrício, Bárbara G; Guimarães, Marta; Nora, Mário; Oliveira, Pedro F.; Alves, Marco G.; Monteiro, Mariana P.. "O perfil metabólico do tecido adiposo visceral varia de acordo com o IMC e status glicémico.". Paper presented in 16º Congresso Português de Diabetes, 2020.
Conference poster
  1. Morais, Tiago; Seabra, Alexandre; Patrício, Bárbara G; Guimarães, Marta; Nora, Mário; Oliveira, Pedro F; Alves, Marco G; Monteiro, Mariana P.. "The metabolomic profile of visceral adipose tissue varies with BMI and glycemic status (“O perfil metabólico do tecido adiposo visceral varia de acordo com o IMC e status glicémico”)". Paper presented in 16th Portuguese Congress of Diabetes, 2020.
  2. Morais, Tiago; Seabra, Alexandre; Patrício, Bárbara G; Guimarães, Marta; Nora, Mário; Oliveira, Pedro F; Alves, Marco G; Monteiro, Mariana P.. "Visceral adipose tissue of obese pre-diabetic individuals have a distict exometabolomic profile". Paper presented in II Meeting of the Doctoral Degree in Biomedical Sciences, 2019.
  3. Patrício, Bárbara. "P05-02YI Changes in individual free fatty acids during an oral glucose tolerance test in lean and obese non-alcoholic fatty liver disease subjects.". Paper presented in EASL NAFLD Summit 2019, 2019.
  4. Alexandre, Seabra; Morais, Tiago; Patrício, Bárbara G; Nora, Mário; Oliveira, Pedro F; Alves, Marco G; Monteiro, Mariana P.. "Visceral adipose tissue of patients with obesity and pre-diabetes has a distinct exometabolomic profiling signature". Paper presented in EASO New Investigators United Autumn School, 2019.
  5. Patrício, Bárbara. "Decreased lysophosphocholines and increased ceramides are associated to obesity and non-alcoholic fatty liver disease". Paper presented in International Symposium – Biomarkers for Personalized Hepatology, 2018.
  6. Morais, Tiago; Patrício, Bárbara; Pereira, Sofia S.; Santos, Madalena; Moreia, Ângela; Andrade, Sara; Monteiro, Duarte; et al. "Effect of chronic glp-1 exposure on the morphology of pancreatic islets of intact and truncal vagotomized rats.". 2015.
Journal article
  1. Ana Reis-Costa; Getachew D. Belew; Ivan Viegas; Ludgero C. Tavares; Maria João Meneses; Patrício, Bárbara G; Amalia Gastaldelli; Maria Paula Macedo; John G. Jones. "The Effects of Long-Term High Fat and/or High Sugar Feeding on Sources of Postprandial Hepatic Glycogen and Triglyceride Synthesis in Mice". Nutrients (2024): https://doi.org/10.3390/nu16142186.
    10.3390/nu16142186
  2. Della Pepa, Giuseppe; Patrício, Bárbara G; Carli, Fabrizia; Sabatini, Silvia; Astiarraga, Brenno; Ferrannini, Ele; Camastra, Stefania; Gastaldelli, Amalia. "GLP-1 receptor agonist treatment improved fasting and postprandial lipidomic profile independently of diabetes and weight loss". Diabetes (2024): http://dx.doi.org/10.2337/db23-0972.
    Published • 10.2337/db23-0972
  3. Morais, Tiago; Seabra, Alexandre L.; Patrício, Bárbara G; Carrageta, David F.; Guimarães, Marta; Nora, Mário; Oliveira, Pedro F.; Alves, Marco G.; Monteiro, Mariana P.. "Dysglycemia Shapes Visceral Adipose Tissue’s Response to GIP, GLP-1 and Glucagon in Individuals with Obesity". Metabolites 13 5 (2023): 587. http://dx.doi.org/10.3390/metabo13050587.
    10.3390/metabo13050587
  4. Morais, Tiago; Seabra, Alexandre L.; Patrício, Bárbara G; Guimarães, Marta; Nora, Mário; Oliveira, Pedro F.; Alves, Marco G.; Monteiro, Mariana P.. "Visceral Adipose Tissue Displays Unique Metabolomic Fingerprints in Obesity, Pre-Diabetes and Type 2 Diabetes". International Journal of Molecular Sciences 22 11 (2021): 5695. http://dx.doi.org/10.3390/ijms22115695.
    10.3390/ijms22115695
  5. Gianluca Svegliati-Baroni; Patrício, Bárbara G; Gessica Lioci; Maria Paula Macedo; Amalia Gastaldelli. "Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH". International Journal of Molecular Sciences 21 16 (2020): 5820-5820. https://doi.org/10.3390/ijms21165820.
    10.3390/ijms21165820
  6. Morais T; Patrício, Bárbara G; Pereira SS; Andrade S; Carreira M; Casanueva FF; Monteiro MP. "GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats.". Journal of cellular biochemistry (2019): http://europepmc.org/abstract/med/30994953.
    10.1002/jcb.28719
  7. Patrício, Bárbara G; M. Gaggini; F. Carli; B. Astiarraga; C. Rosso; E. Ferrannini; E. Bugianesi; S. Camastra; A. Gastaldelli. "Metabolomic profile of morbidly obese NAFLD: effect of weight loss by exenatide or diet". Digestive and Liver Disease 51 (2019): e30-e30. https://doi.org/10.1016%2Fj.dld.2018.11.090.
    10.1016/j.dld.2018.11.090
  8. Patrício, Bárbara G; Tiago Morais; Marta Guimarães; Simon Veedfald; Bolette Hartmann; Linda Hilsted; Jens J. Holst; Mário Nora; Mariana P. Monteiro. "Gut hormone release after gastric bypass depends on the length of the biliopancreatic limb". International Journal of Obesity (2018): https://doi.org/10.1038%2Fs41366-018-0117-y.
    10.1038/s41366-018-0117-y
  9. Nuno Vale; Ana Correia-Branco; Patrício, Bárbara G; Diana Duarte; Fátima Martel. "In vitro studies on the inhibition of colon cancer by amino acid derivatives of bromothiazole". Bioorganic & Medicinal Chemistry Letters (2017): https://doi.org/10.1016/j.bmcl.2017.05.073.
    10.1016/j.bmcl.2017.05.073
Preprint
  1. Pina, Ana F.; Meneses, Maria João; Carli, Fabrizia; Patrício, Bárbara G; Ribeiro, Rogério T.; Patarrão, Rita S.; Gardete-Correia, Luís; et al. "Lipidomic Profiling Unveils Sex Differences in Diabetes Risk: Implications for Precision Medicine". 2023. http://dx.doi.org/10.1101/2023.05.06.23289612.
    10.1101/2023.05.06.23289612
Thesis / Dissertation
  1. "Importance of the Gut-Liver Axis on Lipid Metabolism: Implications in the Pathogenesis of Obesity-Related Non-Alcoholic Fatty Liver Disease". PhD, Scuola Superiore Sant'Anna, 2021. https://dta.santannapisa.it/t/etd-03312021-145906/.
  2. Bárbara Gomes Patrício. "Comparison of the mixed-meal stimulated gut hormone secretion profile after classical gastric bypass and the long biliopancreatic limb variant.". Master, 2017. https://hdl.handle.net/10216/105788.
  3. "Evaluation of GPL-1 effects on pancreatic morphology". Degree, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2015.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/05/08 Effect of the GLP-1RA exenatide or diet in the fasting and postprandial metabolomic profile of morbid obese NAFLD 7th NAFLD Study Group
(Lisbon, Portugal)
2018/04/20 Alterations in plasma lipidomic profile are mainly associated to increased BMI rather than IR 6th NAFLD study group
(Oxford, United Kingdom)
2017/01/14 Could a longer biliopancreatic limb RYGB enhance gastrointestinal hormone response towards improved glycemic control? 2nd EASD Incretin Study Group Meeting
(Pisa, Italy)
2016/04/30 Chronic GLP-1 does not alter general pancreatic morphology but may reduce alpha-cell division rate 50th Portuguese Society of Anatomy Annual Meeting
(Braga, Portugal)
2016/02/18 Vagally mediated exposure to chronic GLP-1 may influence leptin production without changing pancreatic morphology IJUP - Encontro de Investigação Jovem
(Porto, Portugal)

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2017/05/15 Pessoas da U.Porto
Distinctions

Award

2017 SPD National Diabetes Award 2017
Sociedade Portuguesa de Diabetologia, Portugal

Other distinction

2019 Young Investigator Bursary - Conference
EASL International Liver Foundation, Switzerland
2019 Young Investigator Bursary - Conference
ITALIAN ASSOCIATION FOR THE STUDY OF THE LIVER (AISF), Italy