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Sara C. Santos has graduated in Biochemistry in 2016 at University of Aveiro. She concluded her Master degree in Biochemistry - Specialization in Clinical Biochemistry in 2017 also at University of Aveiro. Her master thesis was focused on the development and characterization of human-derived hydrogels as platforms for cell culture. In particular, she developed a novel photopolymerizable material derived from human platelet lysates - methacryloyl platelet lysates (PLMA) - that can be used to form hydrogels. Moreover, she characterized such platelet lysates based hydrogels, either mechanically and biochemically, and proved their ability to be used as a platform for 3D cell culture. Her master thesis work resulted in two papers in international refereed journals, one patent, two oral communications and one poster in international conferences. Afterwards, she was working at COMPASS Research Group (CICECO - Aveiro Institute of Materials, University of Aveiro), focused on the development of new applications for such platelet lysates based materials. Currently, she is a PhD student at COMPASS Research Group working on the development of platelet lysates based platforms for myocardial tissue regeneration. More specifically, she is working on the development of platelet lysates-based bioinks to be used in 3D bioprinting of novel human-based structures for cardiac tissue engineering. Besides that, she is also working on the development and characterization of human extracellular matrix derived platforms to be used for tissue engineering and regenerative medicine strategies. Her main aim is the development of novel human-based strategies for the development of 3D platforms for cell culture, disease modelling or drug screening.
Identification

Personal identification

Full name
Sara Catarina Nunes da Silva Santos

Citation names

  • Santos, Sara C.

Author identifiers

Ciência ID
9D19-33C3-3A22
ORCID iD
0000-0002-9722-1701

Email addresses

  • santossara@ua.pt (Professional)

Addresses

  • Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Portuguese (Mother tongue)
Education
Degree Classification
2019/11/01 - 2023/10/31
Ongoing
Programa Doutoral em Biotecnologia (Doutoramento)
Universidade de Aveiro CICECO, Portugal
"Human plasma derived hydrogels for myocardial tissue engineering" (THESIS/DISSERTATION)
2017/12/18
Concluded
Mestrado em Boquímica (Mestrado)
Major in Bioquímica Clínica
Universidade de Aveiro Departamento de Química, Portugal
"Development of injectable hydrogels derived from human platelet lysates" (THESIS/DISSERTATION)
16
2016/07/08
Concluded
Licenciatura em Bioquímica (Licenciatura)
Universidade de Aveiro Departamento de Química, Portugal
"Alergia de contacto: identificação de haptenos por espetrometria de massa " (THESIS/DISSERTATION)
13
Affiliation

Science

Category
Host institution
Employer
2018/03/19 - 2019/10/31 Researcher (Research) Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro CICECO, Portugal
Projects

Contract

Designation Funders
2019/09/19 - 2019/10/31 ATLAS - Bioengineered autonomous cell-biomaterials devices for generating humanised micro-tissues for regenerative medicine
Research Fellow
Universidade de Aveiro CICECO, Portugal
European Commission
Ongoing
2018/03/01 - 2019/09/18 MicroBone - Novel 3D platforms to engineer bone microtissues for in vitro disease models
Research Fellow
Universidade de Aveiro, Portugal
European Commission
Concluded
Outputs

Publications

Conference poster
  1. Santos, Sara C.; Custódio, Catarina A.; Mano, Joao F.. "Advanced allogeneic porous matrices for personalized cell culture and tissue engineering". Paper presented in TERMIS 2021 – 6th WORLD CONGRESS 2021, 2021.
  2. Santos, Sara C.; Custódio, Catarina A.; Mano, João F.. "Human platelet lysates-based sponges: a solution to culture human cells in serum free conditions". Paper presented in 11th World Biomaterials Congress WBC 2020, 2020.
  3. Santos, Sara C.; Custódio, Catarina A.; Mano, João F.. "Establishment of xenogeneic platforms for 3D cell culture using human protein-based porous scaffolds". Paper presented in TERMIS European Chapter Meeting 2020, 2020.
  4. Santos, Sara C.; Custódio, Catarina A.; Mano, João F.. "Human platelet lysates-based hydrogels: a novel platform for tissue engineering applications". Paper presented in Jornadas CICECO 2019, 2019.
  5. Tavares, Márcia T.; Santos, Sara C.; Farinha, José Paulo S.; Baleizão, Carlos; Custódio, Catarina A.; Mano, João F.. "Platelet Lysate-based Hydrogels Incorporated with Multi-Bioactive Mesoporous Silica Nanoparticles for Stem Cell Osteogenic Differentiation". Paper presented in Jornadas CICECO 2019, 2019.
  6. Santos, Sara C.; Custódio, Catarina A.; Mano, João F.. "Customized platelet lysate based hydrogels for 3D cell culture". Paper presented in 5th TERMIS World Congress, 2018.
Journal article
  1. Santos, Sara C.; Custódio, Catarina A.; Mano, João F.. "Human Protein-Based Porous Scaffolds as Platforms for Xeno-Free 3D Cell Culture". Advanced Healthcare Materials (2022): 2102383. http://dx.doi.org/10.1002/adhm.202102383.
    Published • 10.1002/adhm.202102383
  2. Deus, Inês A.; Santos, Sara C.; Custódio, Catarina A.; Mano, João F.. "Designing highly customizable human based platforms for cell culture using proteins from the amniotic membrane". Materials Science and Engineering: C (2021): 112574. http://dx.doi.org/10.1016/j.msec.2021.112574.
    Published • 10.1016/j.msec.2021.112574
  3. Tavares, Márcia T.; Santos, Sara C.; Custódio, Catarina A.; Farinha, José Paulo S.; Baleizão, Carlos; Mano, João F.. "Platelet Lysates-based Hydrogels Incorporating Bioactive Mesoporous Silica Nanoparticles for Stem Cell Osteogenic Differentiation". Materials Today Bio (2021): 100096. http://dx.doi.org/10.1016/j.mtbio.2021.100096.
    Published • 10.1016/j.mtbio.2021.100096
  4. Monteiro, Cátia F.; Santos, Sara C.; Custódio, Catarina A.; Mano, João F.. "Human Platelet Lysates-Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion Assessment". Advanced Science (2020): 1902398. http://dx.doi.org/10.1002/advs.201902398.
    Open access • Published • 10.1002/advs.201902398
  5. Santos, Sara C.; Custódio, Catarina A.; Mano, João F.. "Photopolymerizable Platelet Lysate Hydrogels for Customizable 3D Cell Culture Platforms". Advanced Healthcare Materials 7 23 (2018): 1800849. http://dx.doi.org/10.1002/adhm.201800849.
    Published • 10.1002/adhm.201800849
  6. Santos, Sara C.; Sigurjonsson, Ólafur E.; Custódio, Catarina A.; Mano, João F.. "Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies". Tissue Engineering Part B: Reviews 24 6 (2018): 454-462. http://dx.doi.org/10.1089/ten.teb.2018.0008.
    Published • 10.1089/ten.teb.2018.0008
Thesis / Dissertation
  1. Santos, Sara C.. "Development of injectable hydrogels derived from human platelet lysates". Master, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22668.

Intellectual property

Patent
  1. Mano, João F.; Custódio, Catarina A.; Santos, Sara C.; Deus, Inês A.. 2021. "Human placental membrane based hydrogel composition, processes and uses thereof".
    Granted/Issued
  2. Mano, João F.; Custódio, Catarina A.; Santos, Sara C.. 2017. "Hydrogels based on blood plasma components, process and uses thereof". Portugal.
    Allowed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11/15 Human protein based platforms for 3D cell culture – a new era for personalized engineering tissues TERMIS 2021 / 6th WORLD CONGRESS 2021
2021/09/05 Human protein-based sponges for fully xeno-free cell culture platforms 31st Annual Conference of the European Society for Biomaterials (ESB 2021)
2021/09/05 Accelerating drug development with human protein based platforms for in vitro 3D cell culture and disease modelling 31st Annual Conference of the European Society for Biomaterials (ESB 2021)
2021/03/17 Human platelet lysates based hydrogels as 3D platforms for tissue engineering and disease modelling applications 2nd Aveiro-Osaka Symposium
2019/05/31 Human platelet lysates-based hydrogels: a novel platform for tissue engineering applications TERMIS European Chapter Meeting 2019
(Rhodes, Greece)
2018/10/02 Designing humanized hydrogels toward tissue engineering and disease modeling 13th International Chemical and Biological Engineering Conference (CHEMPOR 2018)
University of Aveiro and Ordem dos Engenheiros (Aveiro, Portugal)
2018/09/09 Platelet lysate based hydrogels with tunable mechanical properties as platforms for 3D cell culture 29th Annual Meeting of the European Society for Biomaterials
European Society for Biomaterials (Maastricht, Netherlands)
Distinctions

Award

2020 Bluepharma | Univeristy of Coimbra Innovation Award 2019
Bluepharma, Portugal

Universidade de Coimbra, Portugal
2018 Prémio Empreendedorismo Tecnológico - Concurso de Ideias Empreende +
Universidade de Aveiro - Unidade de Transferência de Tecnologia (UATEC), Portugal
2017 PROT IERA - Concurso de materialização de ideias de negócio (1ª edição)
Universidade de Aveiro - Unidade de Transferência de Tecnologia (UATEC), Portugal