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Dr. Aleksandra Zielinska is an Assistant Professor at the Institute of Human Genetics of Polish Academy of Sciences. In 2018, she defended doctoral dissertation entitled Synthesis and characterization of solid lipid nanoparticles and nanostructured lipid carriers intended for cosmetic and pharmaceutical purposes (summa cum laude) at the University of Adam Mickiewicz in Poznan. Her research was partly carried out within a framework of foreign internship at the Faculty of Pharmacy of Freie Universität Berlin (Germany), at the Erlangen Catalysis Resource Center Friedrich-Alexander-Universität Erlangen-Nürnberg (Germany) and at the Faculty of Pharmacy in Coimbra (Portugal). A scientific activity of Dr. A. Zielinska has resulted in numerous scientific publications, chapters in scientific monographs and presentations of research results at national and international conferences, as well as many seminars and scientific workshops with the industry in Poland and abroad (including in Barcelona, Paris, Genoa). Dr. A. Zielinska has been awarded with many prizes for the best presentation of research results. She actively participated in variety of trainings, e.g. in the framework of the Skills Project organized by Foundation for Polish Science. The aim was both to improve qualifications in the field of managing scientific projects and research teams, as well as to develop skills in the field of scientific communication and shaping pro-innovative attitudes. Furthermore, she has been awarded by the Ministry of Science and Higher Education in the TransFormation.doc competition, thanks to which she attended to the Entrepreneurship and Soft Skills Training Necessary for Cooperation with the Economy at the University of Alberta School of Business in Edmonton, in Canada.
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Identification

Personal identification

Full name
Aleksandra Zielinska

Citation names

  • Zielinska, Aleksandra
  • Zielinska, A.; A. Zielinska

Author identifiers

Ciência ID
9B1B-A35C-D809
ORCID iD
0000-0003-2603-1377
Scopus Author Id
56083536600

Email addresses

  • aleksandra.zielinska@igcz.poznan.pl (Professional)

Telephones

Telephone
  • (+48) 616579201 (Professional)

Addresses

  • Strzeszynska 32, 60-479, Poznan, Poznan, Poland (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Nano-technology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Polish (Mother tongue)
English Proficiency (C2) Advanced (C1) Advanced (C1) Proficiency (C2) Advanced (C1)
German Advanced (C1) Upper intermediate (B2) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Portuguese Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Beginner (A1)
Education
Degree Classification
2019/02/23 - 2019/12/07
Concluded
 Clinical Trials and Biomedical Research (Postgraduate Certificate)
Uniwersytet Medyczny imienia Karola Marcinkowskiego w Poznaniu Wydzial II Lekarski, Poland
2014/01/31 - 2018/12/21
Concluded
 Doctoral studies at the Faculty of Chemistry, Laboratory of Applied Chemistry (Doktor (PhD))
Major in Cosmetic and Pharmaceutical Technology
Uniwersytet im Adama Mickiewicza w Poznaniu Wydzial Chemii, Poland
Affiliation

Science

Category
Host institution 		Employer
2020/06/04 - Current Researcher (Research) Instytut Genetyki Czlowieka Polskiej Akademii Nauk, Poland
2016/09/01 - Current Visiting Researcher (Research) Universidade de Coimbra Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2016/10/01 - 2020/03/30 PAIRED: Magnetically and photochemically actuated bioactive Nanowires for remotely controlled drug delivery
M-ERA-NET/0004/2015
Researcher
Universidade de Coimbra Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Zielinska, Aleksandra. "Monoterpenes Based Pharmaceuticals: A Review of Applications in Human Health and Drug Delivery Systems". 2018.
    https://doi.org/10.1201/9781351251983
  2. Zielinska, Aleksandra. "Chapter 10: Mesoporous Silica Nanoparticles as Drug Delivery Systems against Melanoma". 2018.
    https://doi.org/10.1016/B978-0-12-813669-0.00010-5
  3. Zielinska, A.; Pereira, I.; Antunes, S.; Veiga, F.J.; Santos, A.C.; Nowak, I.; Silva, A.M.; Souto, E.B.. "Mesoporous silica nanoparticles as drug delivery systems against melanoma". 437-466. 2018.
  4. Zielinska, Aleksandra. "Chapter 10 - Solid lipid nanoparticles and nanostructured lipid carriers as novel carriers for cosmetic ingredients". 2016.
    https://doi.org/10.1016/B978-0-323-42868-2.00010-3
  5. Zielinska, A.; Nowak, I.. "Solid lipid nanoparticles and nanostructured lipid carriers as novel carriers for cosmetic ingredients". 231-255. 2016.
Journal article
  1. Ana Fernandes; Aleksandra Zielinska; Elena Sánchez López; Tiago dos Santos; Maria Luisa Garcia; Amélia M Silva; Jacek Karczewski; Souto, E.B.. "Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/5/2592.
    10.3390/ijms23052592
  2. Aleksandra Zielinska; Piotr Eder; Lucas Rannier; Juliana C. Cardoso; Patrícia Severino; Amélia M. Silva; Eliana B. Souto. "Hydrogels for modified-release drug delivery systems". Current Pharmaceutical Design (2021): https://doi.org/10.2174/1381612828666211230114755.
    10.2174/1381612828666211230114755
  3. Piotr Eder; Aleksandra Zielinska; Jacek Karczewski; Agnieszka Dobrowolska; Ryszard Slomski; Eliana B. Souto. "How could nanobiotechnology improve treatment outcomes of anti-TNF-a therapy in inflammatory bowel disease? Current knowledge, future directions". Journal of Nanobiotechnology (2021): https://doi.org/10.1186/s12951-021-01090-1.
    10.1186/s12951-021-01090-1
  4. Eliana B. Souto; Ana L. R. de Souza; Fernanda K. dos Santos; Elena Sanchez-Lopez; Amanda Cano; Aleksandra Zielinska; Rafal Staszewski; et al. "Lipid Nanocarriers for Hyperproliferative Skin Diseases". Cancers (2021): https://doi.org/10.3390/cancers13225619.
    10.3390/cancers13225619
  5. Sara Cardoso; Classius F. da Silva; Patrícia Severino; Amélia M. Silva; Selma B. Souto; Aleksandra Zielinska; Jacek Karczewski; Eliana B. Souto. "Genotoxicity Assessment of Metal-Based Nanocomposites Applied in Drug Delivery". Materials 14 21 (2021): 6551-6551. https://doi.org/10.3390/ma14216551.
    10.3390/ma14216551
  6. Eliana B. Souto; Ana S. Macedo; João Dias-Ferreira; Amanda Cano; Aleksandra Zielinska; Carla M. Matos. "Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharmaceutical Ingredients (APIs)". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22189743.
    10.3390/ijms22189743
  7. Eliana B. Souto; Cristiana M. P. Yoshida; Gislaine R. Leonardi; Amanda Cano; Elena Sanchez-Lopez; Aleksandra Zielinska; César Viseras; et al. "Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13081199.
    10.3390/pharmaceutics13081199
  8. Carmen S. Favaro-Trindade; Fernando E. de Matos Junior; Paula K. Okuro; João Dias-Ferreira; Amanda Cano; Patricia Severino; Aleksandra Zielinska; Eliana B. Souto. "Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles for Oral Administration by Spray-Cooling". Pharmaceutics 13 8 (2021): 1186-1186. https://doi.org/10.3390/pharmaceutics13081186.
    10.3390/pharmaceutics13081186
  9. Cecília de Barros; Norberto Aranha; Patrícia Severino; Eliana B. Souto; Aleksandra Zielinska; André Lopes; Alessandra Rios; et al. "Quality by Design Approach for the Development of Liposome Carrying Ghrelin for Intranasal Administration". Pharmaceutics 13 5 (2021): 686-686. https://doi.org/10.3390/pharmaceutics13050686.
    10.3390/pharmaceutics13050686
  10. Marcin Ozarowski; Tomasz M. Karpinski; Aleksandra Zielinska; Eliana B. Souto; Karolina Wielgus. "Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22094294.
    10.3390/ijms22094294
  11. Aleksandra Zielinska; Marlena Szalata; Adam Gorczynski; Jacek Karczewski; Piotr Eder; Patrícia Severino; José M. Cabeda; Eliana B. Souto; Ryszard Slomski. "Cancer Nanopharmaceuticals: Physicochemical Characterization and In Vitro/In Vivo Applications". Cancers (2021): https://doi.org/10.3390/cancers13081896.
    10.3390/cancers13081896
  12. Aleksandra Zielinska; Konrad Kubasiewicz; Krzysztof Wójcicki; Amélia M. Silva; Fernando M. Nunes; Marlena Szalata; Ryszard Slomski; Piotr Eder; Eliana B. Souto. "Two- and Three-Dimensional Spectrofluorimetric Qualitative Analysis of Selected Vegetable Oils for Biomedical Applications". Molecules 25 23 (2020): 5608-5608. https://doi.org/10.3390/molecules25235608.
    10.3390/molecules25235608
  13. Aleksandra Zielinska; Beatriz B. Soles; Ana R. Lopes; Beatriz F. Vaz; Camila M. Rodrigues; Thais F. R. Alves; Dorota Klensporf-Pawlik; et al. "Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications". Biology (2020): https://doi.org/10.3390/biology9100336.
    10.3390/biology9100336
  14. Aleksandra Zielinska; Krzysztof Wójcicki; Dorota Klensporf-Pawlik; João Dias-Ferreira; Massimo Lucarini; Alessandra Durazzo; Giuseppe Lucariello; et al. "Chemical and Physical Properties of Meadowfoam Seed Oil and Extra Virgin Olive Oil: Focus on Vibrational Spectroscopy". Journal of Spectroscopy (2020): https://doi.org/10.1155/2020/8870170.
    10.1155/2020/8870170
  15. Cecilia T. de Barros; Alessandra C. Rios; Thaís F. R. Alves; Fernando Batain; Kessi M. M. Crescencio; Laura J. Lopes; Aleksandra Zielinska; et al. "Cachexia: Pathophysiology and Ghrelin Liposomes for Nose-to-Brain Delivery". International Journal of Molecular Sciences 21 17 (2020): 5974-5974. https://doi.org/10.3390/ijms21175974.
    10.3390/ijms21175974
  16. Aleksandra Zielinska; Filipa Carreiró; Ana M. Oliveira; Andreia Neves; Bárbara Pires; D. Nagasamy Venkatesh; Alessandra Durazzo; et al. "Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology". Molecules 25 16 (2020): 3731-3731. https://doi.org/10.3390/molecules25163731.
    10.3390/molecules25163731
  17. Anna Maria Rychter; Marzena Skrzypczak-Zielinska; Aleksandra Zielinska; Piotr Eder; Eliana B. Souto; Agnieszka Zawada; Alicja Ewa Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kazmierczak. "Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?". International Journal of Molecular Sciences 21 15 (2020): 5229-5229. https://doi.org/10.3390/ijms21155229.
    10.3390/ijms21155229
  18. Ida Judyta Malesza; Michal Malesza; Iwona Krela-Kazmierczak; Aleksandra Zielinska; Eliana B. Souto; Agnieszka Dobrowolska; Piotr Eder. "Primary Humoral Immune Deficiencies: Overlooked Mimickers of Chronic Immune-Mediated Gastrointestinal Diseases in Adults". International Journal of Molecular Sciences 21 15 (2020): 5223-5223. https://doi.org/10.3390/ijms21155223.
    10.3390/ijms21155223
  19. Aleksandra Zielinska; Henrique Alves; Vânia Marques; Alessandra Durazzo; Massimo Lucarini; Thais F. Alves; Margreet Morsink; et al. "Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects". Medicina (2020): https://doi.org/10.3390/medicina56070336.
    10.3390/medicina56070336
  20. Aleksandra Zielinska; Beatriz Costa; Maria V. Ferreira; Diogo Miguéis; Jéssica M. S. Louros; Alessandra Durazzo; Massimo Lucarini; et al. "Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance". International Journal of Environmental Research and Public Health 17 13 (2020): 4657-4657. https://doi.org/10.3390/ijerph17134657.
    10.3390/ijerph17134657
  21. Eliana B. Souto; Gabriela F. Silva; João Dias-Ferreira; Aleksandra Zielinska; Fátima Ventura; Alessandra Durazzo; Massimo Lucarini; Ettore Novellino; Antonello Santini. "Nanopharmaceutics: Part II—Production Scales and Clinically Compliant Production Methods". Nanomaterials 10 3 (2020): 455-455. https://doi.org/10.3390/nano10030455.
    10.3390/nano10030455
  22. Eliana B. Souto; Aleksandra Zielinska; Selma B. Souto; Alessandra Durazzo; Massimo Lucarini; Antonello Santini; Amélia M. Silva; et al. "(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line". International Journal of Molecular Sciences 21 4 (2020): 1449-1449. https://doi.org/10.3390/ijms21041449.
    10.3390/ijms21041449
  23. Eliana B. Souto; Gabriela F. Silva; João Dias-Ferreira; Aleksandra Zielinska; Fátima Ventura; Alessandra Durazzo; Massimo Lucarini; Ettore Novellino; Antonello Santini. "Nanopharmaceutics: Part I—Clinical Trials Legislation and Good Manufacturing Practices (GMP) of Nanotherapeutics in the EU". Pharmaceutics 12 2 (2020): 146-146. https://doi.org/10.3390/pharmaceutics12020146.
    10.3390/pharmaceutics12020146
  24. Souto, E.B.; Selma B. Souto; Aleksandra Zielinska; Alessandra Durazzo; Massimo Lucarini; Antonello SANTINI; Olaf K. Horbanczuk; et al. "Perillaldehyde 1,2-epoxide Loaded SLN-Tailored mAb: Production, Physicochemical Characterization and In Vitro Cytotoxicity Profile in MCF-7 Cell Lines". Pharmaceutics (2020): https://www.mdpi.com/1999-4923/12/2/161.
    10.3390/pharmaceutics12020161
  25. C. Carbone; V. Fuochi; A. Zielinska; T. Musumeci; E.B. Souto; A. Bonaccorso; C. Puglia; G. Petronio Petronio; P.M. Furneri. "Dual-drugs delivery in solid lipid nanoparticles for the treatment of Candida albicans mycosis". Colloids and Surfaces B: Biointerfaces 186 (2020): 110705-110705. https://doi.org/10.1016/j.colsurfb.2019.110705.
    10.1016/j.colsurfb.2019.110705
  26. Venkatesh, D.N.; Meyyanathan, S.N.; Shanmugam, R.; Zielinska, A.; Campos, J.R.; Ferreira, J.D.; Souto, E.B.. "Development, in vitro release and in vivo bioavailability of sustained release nateglinide tablets". Journal of Drug Delivery Science and Technology 55 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074416600&partnerID=MN8TOARS.
    10.1016/j.jddst.2019.101355
  27. Zielinska, A.; Ferreira, N.R.; Feliczak-Guzik, A.; Nowak, I.; Souto, E.B.. "Loading, release profile and accelerated stability assessment of monoterpenes-loaded solid lipid nanoparticles (SLN)". Pharmaceutical Development and Technology 25 7 (2020): 832-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-85082422752&partnerID=MN8TOARS.
    10.1080/10837450.2020.1744008
  28. Souto, E.B.; da Ana, R.; Souto, S.B.; Zielinska, A.; Marques, C.; Andrade, L.N.; Horbanczuk, O.K.; et al. "In vitro characterization, modelling, and antioxidant properties of polyphenon-60 from green tea in eudragit s100-2 chitosan microspheres". Nutrients 12 4 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85083041617&partnerID=MN8TOARS.
    10.3390/nu12040967
  29. Eliana B. Souto; Slavomira Doktorovova; Aleksandra Zielinska; Amélia M. Silva. "Key production parameters for the development of solid lipid nanoparticles by high shear homogenization". Pharmaceutical Development and Technology 24 9 (2019): 1181-1185. https://doi.org/10.1080/10837450.2019.1647235.
    10.1080/10837450.2019.1647235
  30. Thallysson Carvalho Barbosa; Lívia Éven Dias Nascimento; Cristiane Bani; Taline Almeida; Marcelo Nery; Rafael Santos; Luana Renyelle de Oliveira Menezes; et al. "Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(e-caprolactone) Nanocapsules". Toxics (2019): https://www.mdpi.com/2305-6304/7/4/51.
    10.3390/toxics7040051
  31. Zielinska, Aleksandra. "Development and Optimization of Alpha-Pinene-Loaded Solid Lipid Nanoparticles (SLN) Using Experimental Factorial Design and Dispersion Analysis". Molecules (2019):
    10.3390/molecules24152683
  32. Souto, E.B.; Campos, J.C.; Filho, S.C.; Teixeira, M.C.; Martins-Gomes, C.; Zielinska, A.; Carbone, C.; Silva, A.M.. "3D printing in the design of pharmaceutical dosage forms". Pharmaceutical Development and Technology 24 8 (2019): 1044-1053. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068065962&partnerID=MN8TOARS.
    10.1080/10837450.2019.1630426
  33. Campos, J.R.; Severino, P.; Ferreira, C.S.; Zielinska, A.; Santini, A.; Souto, S.B.; Souto, E.B.. "Linseed essential oil – Source of lipids as active ingredients for pharmaceuticals and nutraceuticals". Current Medicinal Chemistry 26 24 (2019): 4537-4558. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074082178&partnerID=MN8TOARS.
    10.2174/0929867325666181031105603
  34. Souto, E.B.; Zielinska, A.; Luis, M.; Carbone, C.; Martins-Gomes, C.; Souto, S.B.; Silva, A.M.. "Uveal melanoma: physiopathology and new in situ-specific therapies". Cancer Chemotherapy and Pharmacology 84 1 (2019): 15-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065741902&partnerID=MN8TOARS.
    10.1007/s00280-019-03860-z
  35. Zielinska, Aleksandra. "Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer®". International Journal of Pharmaceutics (2018):
    10.1016/j.ijpharm.2018.10.065
  36. Zielinska, Aleksandra. "Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method". International Journal of Pharmaceutics (2018):
    10.1016/j.ijpharm.2018.07.068
  37. Zielinska, Aleksandra. "Abundance of active ingredients in sea-buckthorn oil". Lipids in Health and Disease (2017):
    https://doi.org/10.1186/s12944-017-0469-7
  38. Zielinska, A.; Nowak, I.. "Abundance of active ingredients in sea-buckthorn oil". Lipids in Health and Disease 16 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019846032&partnerID=MN8TOARS.
    10.1186/s12944-017-0469-7
  39. Zielinska, Aleksandra. "Stability determination of formulations containing hyaluronic acid". International Journal of Cosmetic Science (2015):
    https://doi.org/10.1111/ics.12210
  40. Dabrowska, M.; Zielinska, A.; Nowak, I.. "Lipid oxidation products as a potential health and analytical problem". Chemik 69 2 (2015): 89-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924520113&partnerID=MN8TOARS.
  41. Olejnik, A.; Goscianska, J.; Zielinska, A.; Nowak, I.. "Stability determination of the formulations containing hyaluronic acid". International Journal of Cosmetic Science 37 4 (2015): 401-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936891118&partnerID=MN8TOARS.
    10.1111/ics.12210
  42. Zielinska, A.; Nowak, I.. "Fatty acids in vegetable oils and their importance in cosmetic industry". Chemik 68 2 (2014): 103-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896841575&partnerID=MN8TOARS.
  43. Zielinska, A.; Nowak, I.. "Tocopherols and tocotrienols as vitamin E". Chemik 68 7 (2014): 585-591. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905683012&partnerID=MN8TOARS.
Activities

Association member

Society Organization name Role
2019/05/01 - 2020/05/01 Bentham Science Ambassador 2019-2020 by Bentham Science Publisher

Conference scientific committee

Conference name Conference host
2019/12/01 - 2020/08/14 Member of Organizing Committee of Pharmacy Conference 2020 in Atlanta, USA
Distinctions

Award

2017 2nd Award for The Best Oral Presentation entitled “Synthesis of solid lipid nanoparticles and nanostructured lipid carriers for pharmaceutical and cosmetic purposes”
6th European Young Engineers Conference (EYEC), Poland
2016 Poster Prize for the poster entitled “Marula oil as a successor of argan oil”
5th European Young Engineers Conference (EYEC), Poland
2016 Poster Prize for the poster entitled “Encapsulation of carbamazepine in solid lipid nanoparticles for immediate drug release”
18th JCF-Frühjahrssymposium 2016, Germany
2015 Poster Prize for the poster entitled “Meadowfoam seed oil loaded nanostructured lipid carriers (NLC) with optimized particle matrix for drug delivery”
17th JCF-Frühjahrssymposium 2015, Germany

Title

2020 Guest Editor of Special Issue „Current Research on the Cytotoxicity of Drugs to Animals and Human” in „Toxics”
Multidisciplinary Digital Publishing Institute AG, Switzerland
2020 Review Editor for Ethnopharmacology