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Débora Cristina Domingos Varela. Concluiu o(a) Mestrado em Biologia Molecular e Microbiana em 2017/11/28 pelo(a) Universidade do Algarve Faculdade de Ciências e Tecnologia, Mestrado em Biologia Molecular e Microbiana em 2017 pelo(a) Universidade do Algarve Faculdade de Ciências e Tecnologia e Licenciatura em Bioquímica em 2014/07/18 pelo(a) Universidade do Algarve Faculdade de Ciências e Tecnologia. Recebeu 1 prémio(s) e/ou homenagens. Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia Molecular, Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia Celular, Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Genética e Hereditariedade, Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Bioquímica e Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Genética Humana. Nas suas atividades profissionais interagiu com 3 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Síndrome de Holt-Oram; TBX5; Malformações cardíacas-esqueléticas; Regulação transcricional; Modelo peixe-zebra; Domínio/Área Científica::Ciências Naturais::Ciências Biológicas; .
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Identification

Personal identification

Full name
Débora Cristina Domingos Varela

Citation names

  • Débora Varela

Author identifiers

Ciência ID
9A1C-DFE4-98C9

Email addresses

  • a44771@ualg.pt (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Genetics and Heredity
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Advanced (C1)
Spanish; Castilian Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
French Beginner (A1) Elementary (A2) Beginner (A1) Beginner (A1)
Education
Degree Classification
2019/03/01 - 2023
Ongoing
 Ciências Biomédicas (Doutoramento)
Universidade do Algarve, Portugal
"Epigenetic regulation of ZNF687 in bone cells: elucidation of its role in progression of Paget’s disease towards giant cell tumor of bone" (THESIS/DISSERTATION)
2017
Concluded
 Biologia Molecular e Microbiana (Mestrado)
Major in Sem especialização
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Genetic and functional analysis of specific TBX5 mutations associated with Holt-Oram Syndrome" (THESIS/DISSERTATION)
 19 valores
2014/07/18
Concluded
 Bioquímica (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2018/05/01 - 2019/01/31 Research Trainee (Research) Centro de Ciências do Mar, Portugal

Others

Category
Host institution 		Employer
2015/09/14 - 2017/11/28 Estudante de mestrado em Biologia Molecular e Microbiana Universidade do Algarve, Portugal
2011/09/26 - 2014/07/18 Estudante de licenciatura em Bioquímica Universidade do Algarve, Portugal
Projects

Grant

Designation Funders
2019/03/01 - Current Epigenetic regulation of ZNF687 in bone cells: elucidation of its role in progression of Paget’s disease towards giant cell tumor of bone
SFRH/BD/141918/2018
PhD Student Fellow
Centro de Ciências do Mar, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference abstract
  1. Débora Varela; Natércia Conceição; Ângela Ferreira; Nuno Marques; Ana Paula Silva; M. Leonor Cancela. "Functional analysis of a novel TBX5 c.246_249delGATG mutation present in a Holt-Oram syndrome patient". Paper presented in II Jornadas Algarve Biomedical Center, Olhão, 2018.
Conference poster
  1. Débora Varela; Tatiana Varela; Natércia Conceição; Pedro Azevedo; Salomé Pereira; Ana Camacho; Ilídio de Jesus; M. Leonor Cancela. "Functional analysis of a novel TBX5 c.905delA mutation present in a Holt-Oram syndrome patient". Paper presented in III Jornadas Algarve Biomedical Center, 2019.
  2. Débora Varela; Natércia Conceição; M. Leonor Cancela. "Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors". Paper presented in VIII National RNA meeting: ptRNA2019, 2019.
  3. Débora Varela; Natércia Conceição; Ângela Ferreira; Nuno Marques; Ana Paula Silva; M. Leonor Cancela. "Functional analysis of a novel TBX5 c.246_249delGATG mutation present in a Holt-Oram syndrome patient". Paper presented in II Jornadas Algarve Biomedical Center, 2018.
  4. Débora Varela; M. Leonor Cancela; Natércia Conceição. "Initial validation of zebrafish as model for Holt-Oram syndrome". Paper presented in FishBone workshop, European calcified tissue society meeting, Salzburg, Austria, 2017.
  5. Débora Varela; Ana Alfaia; Sara Mariano; Tatiana Varela; José Matos; Tatiana Authier; M. Leonor Cancela; Natércia Conceição. "Bioinformatic analysis of CCDC3 gene: A potential contributor for paget disease of bone?". Paper presented in XL Jornadas portuguesas de genética, 2016.
Thesis / Dissertation
  1. Cancela, Leonor; Conceição, Natércia; Varela, Débora Cristina Domingos. "Genetic and functional analysis of specific TBX5 mutations associated with Holt-Oram Syndrome". Master, 2017. http://hdl.handle.net/10400.1/10470.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/03/28 Functional analysis of a novel TBX5 c.905delA mutation present in a Holt-Oram syndrome patient III Jornadas Algarve Biomedical Center
Algarve Biomedical Center (ABC) (Albufeira, Portugal)
2018/05/23 Genetic and functional analysis of specific TBX5 mutations associated with Holt-Oram syndrome Biotechnology of animal cells included in BSc in Biomedical Sciences
(Portugal)
2018/02/22 Genetic and functional analysis of specific TBX5 mutations associated with holt-oram syndrome Gene Expression and Pathologies Seminars included in Master in Molecular and Microbial Biology
(Portugal)
2017/03/23 Genetic and functional analysis of specific TBX5 mutations associated with holt-oram syndrome Eukaryotes Molecular Genetics Seminars included in Master in Molecular and Microbial Biology
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/04/01 - 2019/07/09 Effect of promoter methylation on binding of transcription factors regulating ZNF687 expression
Co-supervisor
 Biomedical Sciences (Degree)
Universidade do Algarve, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/06/12 - 2018/06/16 Voluntary staff member during the organization of VII Congress of the Iberian Society for Icthyology (2018/06/12 - 2018/06/16)
Congress
 Centro de Ciências do Mar, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/03/26 - Current Workshop "Projecto ALGARED+: Novas microalgas, Novas aplicações"
Workshop
Centro de Ciências do Mar, Portugal
2019/07/15 - 2019/07/17 Advanced training course in "Zebrafish tools for the screening of osteogenic compounds"
Centro de Ciências do Mar, Portugal
2019/07/11 - 2019/07/12 Workshop "Data and Text Processing in Health and Life Sciences - an example driven workshop using shell scripting"
Workshop
Universidade do Algarve, Portugal
2019/06/03 - 2019/06/04 Advanced training course "Introduction to Python for scientists"
Centro de Ciências do Mar, Portugal
2019/05/27 - 2019/05/28 Advanced training course "R for Absolute beginners (7th Edition)"
Centro de Ciências do Mar, Portugal
2019/03/28 - 2019/03/29 III Jornadas Algarve Biomedical Center
Conference
2018/06/12 - 2018/06/12 VII Congress of the Iberian Society for Icthyology
Congress
 VII Congress of the Iberian Society for Icthyology
Centro de Ciências do Mar, Portugal
2018/04/20 - 2018/04/20 XXV Aniversário do Curso de Bioquímica
Conference
2018/04/19 - 2018/04/19 IX Jornadas Nacionais de Ciências Biomédicas
Conference
 IX Jornadas Nacionais de Ciências Biomédicas
2018/03/16 - 2018/03/16 II Jornadas Algarve Biomedical Center
Congress
 II Jornadas Algarve Biomedical Center
2017/02/23 - 2017/02/23 Workshop in Gene delivery for biomedical applications
Workshop
 Gene delivery for biomedical applications
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2012/11/23 - 2012/11/23 Workshop in Natural products with antiparasitic applications
Workshop
 Natural products with antiparasitic applications
Centro de Ciências do Mar, Portugal
Distinctions

Award

2017 Melhor poster de investigação translacional