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Torcato José Novais Martins has a Degree in Biochemistry (2006) from the Faculdade de Ciencias e Tecnologia, University of Coimbra and completed his PhD in Biomedical Sciences in 2010 from the Instituto de Ciências Biomédicas Abel Salazar, University of Porto. Currently, he is a CEEC Auxiliary Researcher at Universidade de Aveiro. Published 14 articles in journals. Organized 3 events and participated in 4 events. He is the supervisor of 1 PhD student, directly supervised 4 MSc dissertations and co-supervised 5. Supervised 1 work of course completion of LSc/BSc and co-supervised 1. Has received 7 awards and/or honours. Participated as Co-Principal Investigator (Co-PI) in 1 project, PhD Student Fellow in 2 projects, Post-doc Fellow in 1 project, Research Fellow in 3 projects and was awarded 2 competitive Marie Curie Fellowships. Works in the area of Biological Sciences with emphasis on Developmental Biology. In his curriculum, Ciência Vitae the most frequent terms in the context of scientific output are: Drosophila; Growth; Mitosis; Signalling pathways; CRISPR/Cas9; Live imaging.
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Identification

Personal identification

Full name
Torcato José Novais Martins

Citation names

  • Martins, Torcato
  • Martins, T

Author identifiers

Ciência ID
9A16-86FE-9388
ORCID iD
0000-0002-9359-7111

Email addresses

  • torcato.martins@gmail.com (Professional)
  • torcato@ua.pt (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Developmental Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2006 - 2010/11/29
Concluded
 Biomedical Sciences (Doutoramento)
Major in Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"The Role of Sgt1 in Cell Division" (THESIS/DISSERTATION)
2001/09 - 2006/07
Concluded
 Bioquímica (Licenciatura)
Major in Investigacao
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 17/20
Affiliation

Science

Category
Host institution 		Employer
2023/03/01 - Current Auxiliary Researcher (Research) Universidade de Aveiro, Portugal
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021/01/01 - 2022/12/31 Researcher (Research) Universidade de Aveiro, Portugal
Universidade de Aveiro Instituto de Biomedicina, Portugal
2017/09/01 - 2020/12/31 Researcher (Research) University of Cambridge Department of Physiology Development and Neuroscience, United Kingdom
University of Cambridge Department of Physiology Development and Neuroscience, United Kingdom
2015/09/01 - 2017/08/31 Researcher (Research) University of Cambridge Department of Genetics, United Kingdom
University of Cambridge Department of Genetics, United Kingdom
2014/03/01 - 2015/08/31 Researcher (Research) University of Cambridge Department of Genetics, United Kingdom
University of Cambridge Department of Genetics, United Kingdom
2010/12/01 - 2014/03/01 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projects

Grant

Designation Funders
2021/03 - 2024/03 Uma abordagem de transcriptómica subcelular para estudar a gametogênese feminina
159544PRJ
Researcher
Fundação para a Ciência e a Tecnologia
2021/01/01 - 2022/12/31 Genetic and epigenetic resistance to oncogenic transformation of an epithelium
893260
Principal investigator
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
 European Commission
Concluded
2015/09/01 - 2017/08/31 Spatial-temporal regulation of APC/C, its role on G1 arrest and impact on terminal differentiation
info:eu-repo/grantAgreement/EC/H2020/655297/EU
Principal investigator
University of Cambridge, United Kingdom
 European Commission
Concluded
2013/06 - 2014/08 Identification of new players of Rho 1 signalling pathway involved in delivering Rho1 message in the nucleus
Provided by PTCRIS: 125558
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia, I.P.
2011/04 - 2014/03 REGULATION OF THE DROSOPHILA RETINAL PRECURSOR-PROGENITOR TRANSITION BY HTH TARGET GENES WITH TRANSCRIPTIONAL REGULATORY FUNCTION
30968DFA
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
2008/01 - 2010/12 Molecular dissection of the spindle assembly checkpoint proteins in Drosophila
Provided by PTCRIS: 64224
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, I.P.
2006/10 - 2010/09 THE ROLE OF SGT1 IN KINETOCHORE ASSEMBLY
20160DFA
PhD Student Fellow
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2023/03/01 - 2029/02/28 Epigenetic modulation of oncogenic transformation during epithelial differentiation
2022.02406.CEECIND/CP1720/CT0014
10.54499/2022.02406.CEECIND/CP1720/CT0014
Principal investigator
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Castro, Laura Jesus; Martins, Torcato; Martinho, Rui Gonçalo. "What makes a cell reponsive to oncogenes?". Paper presented in Drostuga 2022, 2022.
  2. Marta Pinho; Nadia Eusebio; Eva Carvalho; Rita Pinto; Liliana Rodrigues ; Martins, Torcato; S. Pereira, Paulo. "Drosophila eye targeted combinatorial RNAi screen to identify novel TGFß signaling regulators". Paper presented in 10th International BMP Conference, 2014.
Journal article
  1. Meghini, Francesco; Martins, Torcato; Zhang, Qian; Loyer, Nicolas; Trickey, Michelle; Abula, Yusanjiang; Yamano, Hiroyuki; Januschke, Jens; Kimata, Yuu. "APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.". EMBO reports (2023): http://dx.doi.org/10.15252/embr.202255607.
    Published • 10.15252/embr.202255607
  2. Martins, Torcato; Yao Meng; Boguslawa Korona; Richard Suckling; Steven Johnson; Penny A Handford; Susan M Lea; Sarah J Bray. "The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling". EMBO reports (2021): https://doi.org/10.15252/embr.202152729.
    10.15252/embr.202152729
  3. Boukhatmi, Hadi; Martins, Torcato; Pillidge, Zoe; Kamenova, Tsveta; Bray, Sarah. "Notch Mediates Inter-tissue Communication to Promote Tumorigenesis". Current Biology (2020): http://dx.doi.org/10.1016/j.cub.2020.02.088.
    10.1016/j.cub.2020.02.088
  4. Barbosa, João; Martins, Torcato; Bange, Tanja; Tao, Li; Conde, Carlos; Sunkel, Claudio. "Polo regulates Spindly to prevent premature stabilization of kinetochore–microtubule attachments". The EMBO Journal 39 2 (2019): http://dx.doi.org/10.15252/embj.2018100789.
    10.15252/embj.2018100789
  5. Liu, Xiaochuan; Freitas, Jaime; Zheng, Dinghai; Oliveira, Marta S.; Hoque, Mainul; Martins, Torcato; Henriques, Telmo; Tian, Bin; Moreira, Alexandra. "Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster". RNA 23 12 (2017): 1807-1816. http://dx.doi.org/10.1261/rna.062661.117.
    10.1261/rna.062661.117
  6. Torcato Martins; Nadia Eusebio; Andreia Correia; Joana Marinho; Fernando Casares; Paulo S. Pereira. "TGFß/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands". Open Biology 7 1 (2017): 160258-160258. https://doi.org/10.1098/rsob.160258.
    10.1098/rsob.160258
  7. Martins T; Meghini F; Florio F; Kimata Y. "The APC/C Coordinates Retinal Differentiation with G1 Arrest through the Nek2-Dependent Modulation of Wingless Signaling.". (2016): http://europepmc.org/abstract/med/28041905.
    10.1016/j.devcel.2016.12.005
  8. Francesco Meghini; Torcato Martins; Xavier Tait; Kazuyuki Fujimitsu; Hiroyuki Yamano; David M. Glover; Yuu Kimata. "Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit". Nature Communications 7 1 (2016): https://doi.org/10.1038/ncomms12607.
    10.1038/ncomms12607
  9. Tavares, L.; Pereira, E.; Correia, A.; Santos, M.A.; Amaral, N.; Martins, T.; Relvas, J.B.; Pereira, P.S.. "Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactions". GLIA 63 7 (2015): 1155-1165. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928206519&partnerID=MN8TOARS.
    10.1002/glia.22806
  10. Martins, T.; Kotadia, S.; Malmanche, N.; Sunkel, C.E.; Sullivan, W.. "Strategies for outcrossing and genetic manipulation of drosophila compound autosome stocks". G3: Genes, Genomes, Genetics 3 1 (2013): 1-4. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883148310&partnerID=MN8TOARS.
    10.1534/g3.112.004481
  11. Marinho, J.; Martins, T.; Neto, M.; Casares, F.; Pereira, P.S.. "The nucleolar protein Viriato/Nol12 is required for the growth and differentiation progression activities of the Dpp pathway during Drosophila eye development". Developmental Biology 377 1 (2013): 154-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876321493&partnerID=MN8TOARS.
    10.1016/j.ydbio.2013.02.003
  12. Pinto, P.A.B.; Henriques, T.; Freitas, M.O.; Martins, T.; Domingues, R.G.; Wyrzykowska, P.S.; Coelho, P.A.; et al. "RNA polymerase II kinetics in polo polyadenylation signal selection". EMBO Journal 30 12 (2011): 2431-2444. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958859723&partnerID=MN8TOARS.
    10.1038/emboj.2011.156
  13. Martins, T.; Maia, A.F.; Steffensen, S.; Sunkel, C.E.. "Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization". EMBO Journal 28 3 (2009): 234-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649124272&partnerID=MN8TOARS.
    10.1038/emboj.2008.283
  14. Martins, T.; Sunke, C.E.. "Sgt1 plays polo during cell division". Cell Cycle 8 8 (2009): 1110-1111. http://www.scopus.com/inward/record.url?eid=2-s2.0-65949108017&partnerID=MN8TOARS.
Preprint
  1. Martins, Torcato; Meng, Yao; Korona, Boguslawa; Suckling, Richard; Johnson, Steven; Handford, Penny; Lea, Susan M.; Bray, Sarah. "Delta C2 Domain ß1-2 loop contributes to robust Notch signalling". 2021. http://dx.doi.org/10.1101/2021.02.16.431397.
    10.1101/2021.02.16.431397
Thesis / Dissertation
  1. Martins, Torcato José Novais. "The role of Sgt1 in cell division". PhD, 2011. http://hdl.handle.net/10216/46000.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/05/26 Epigenetic modulation of oncogenic transformation during epithelial differentiation VI iBiMED Symposium: From Fundamental Research to Clinical Practice
University of Aveiro (Aveiro, Portugal)
2023/03/17 Presenting Drosophila melanogaster as a model for biomedical sciences XIII Jornadas Nacionais de Ciências Biomédicas
(Aveiro, Portugal)
2022/06/28 Epigenetic modulation of oncogenic transformation during epithelial differentiation III International Meeting of the Portuguese Society of Genetics
Portuguese Society of Genetics (Evora, Portugal)
2018/04/20 Insights on how membrane composition affects Notch signalling PDN Symposium
Department of Physiology, Development and Neuroscience, University of Cambridge (Cambridge, United Kingdom)
2017/02/21 The APC/C coordinates retinal differentiation with the cell cycle through the Nek2-dependent modulation of Wingless signalling Cell Cycle Club
Crik Institute (London, United Kingdom)
2016/09/10 The APC/C coordinates retinal differentiation with the cell cycle through the Nek2-dependent modulation of Wingless signalling Portuguese Drosophila meeting (DrosTuga)
DrosTuga (Tomar, Portugal)
2010/06/02 Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization XXXV Portuguese Genetics Conference
Sociedade Portuguesa de Genetica (Braga, Portugal)
2009/11/21 Monitoring chromosome segregation 21st European Drosophila Research Conference
European Drosophila Research (Nice, France)
2007/12/21 DmSgt1 is required to maintain spindle bipolarity through a mechanism that involves Polo stabilization Portuguese Drosophila meeting (DroTuga),
DroTuga (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/03/01 - Current Understanding germline resilience to oncogenic transformation
Supervisor of Jadna Martins
 Molecular Biomedicine (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024/01/01 - Current Developmental regulation of the pioneer activity of Grh
Supervisor of Laura Castro
 Biomedicine (PhD)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023/10/01 - Current Finding the mechanisms underlying cell-intrinsic resistance to oncogenesis.
Supervisor of Henrique Nobrega
 Cell and Molecular Biology (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal

Universidade de Aveiro Departamento de Biologia, Portugal
2023/09/01 - Current Epigenetic regulation of Drosophila oocyte determination and differentiation.
Co-supervisor
 Molecular Biomedicine (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021/09/01 - 2022/12/13 Characterization of DNA Repair Systems in Acute Myeloblastic Leukemia: Implications in therapy response
Co-supervisor
 Master in Molecular Biomedicine (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021/09/01 - 2022/07/25 Finding the mechanisms underlying cell intrinsic resistance to oncogenesis.
Supervisor of Laura Castro
 Molecular Biomedicine (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/09/01 - 2019/07/01 The role of Dl C2 Domain on Cell-ECM crosstalk
Co-supervisor
University of Cambridge Department of Physiology Development and Neuroscience, United Kingdom
2015/09/01 - 2016/06/01 Development of molecular tools to follow APC/C activation in vivo
Co-supervisor
University of Cambridge Department of Genetics, United Kingdom
2015/09/05 - 2016/05/28 Genetic screen to identify cell cycle players controlling tumourigenesis
Co-supervisor
University of Cambridge Department of Genetics, United Kingdom
2016/01/01 - 2016/05/15 Regulation of tumourigenesis by the APC/C activator Fzy
Supervisor
University of Cambridge Department of Genetics, United Kingdom
2014/09/02 - 2015/06/04 Identification of the dNek2 interactors during Drosophila development
Co-supervisor
University of Cambridge Department of Genetics, United Kingdom
2011/09/01 - 2012/06/15 The role of TGF-beta on nucleolar modulation
Supervisor
Universidade do Porto Departamento de Química e Bioquímica, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/10/26 - Current Workshop: From Insect to the Bedside (2022/10/26)
Workshop (Co-organisor)
 Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022/01/08 - Current Organization of the annual Drosophila conference - DrosTuga 2022 (2022)
Conference (Co-organisor)
2018/09/01 - 2019/03/21 PDN symposium 2019 (2019/03/21 - 2019/03/22)
Conference (Co-organisor)
 University of Cambridge, United Kingdom

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/03/11 - Current Round table to discuss the latest development in cancer research with the general public.
Round table
 Vamos falar de Cancro
2022/09/30 - Current Coordinator of the DCM participation in the European Researchers’ Night
Festival
 European Researchers’ Night
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021 - Current Responsible to present the iBiMED’s Drosophila Facility on outreach activities such as Xperimenta UA, DCM open day, High school students visits
Exhibition
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2019 Training in Leadership “Emerging Research Leaders’ Development Programme 2019”
Workshop
 Training in Leadership - Emerging Research Leaders’ Development Programme 2019
University of Cambridge, United Kingdom

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/05 Demonstração que os Microtúbulos regulam a via de sinalização Hippo na asa da Drosophila melanogaster.
(Thesis) Main arguer
 Maria João Pereira Ferreira (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2023/10/11 Characterization of novel regulators of the TGF-beta /BMP pathway in proliferation and differentiation in Drosophila melanogaster
(Thesis) Main arguer
 Adriana Valentim Serra (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2023/07/14 Mechanisms of resistance to anti-Her2 drugs used in breast cancer
(Thesis) Main arguer
 Adriana Patrícia Freitas Matias (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2013 Examiner of Margarida Moura
(Thesis) Main arguer
 Margarida Moura (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 Examiner of Pedro Guiomar
(Thesis) Main arguer
 Pedro Guiomar (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 Examiner of MSc Ricardo Sousa
(Thesis) Main arguer
 Ricardo Sousa (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Committee member

Activity description
Role 		Institution / Organization
2022/01/01 - Current Involved in the iBiMED Green Team to promote sustainability in scientific practices.
Member
 Universidade de Aveiro Instituto de Biomedicina, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/02/15 - Current Sistemas Orgânicos e Funcionais IV Ciências Biomédicas (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021/09/01 - Current Laboratories in Biomedicine III Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024/02/23 - 2024/02/23 New technologies and experimental models in biomedicine New technologies and experimental models in biomedicine (Pós-Graduação) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021 - 2022 Sistemas Orgânicos e Funcionais II (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2015 - 2016 Problem Based Learning exercise, MIMS (Bachelor) University of Cambridge Department of Biochemistry, United Kingdom
2014 - 2014 Demonstrator of Cell and Developmental Biology Practical Cell and Developmental Biology (Bachelor) University of Cambridge Department of Zoology, United Kingdom
2006 - 2010 GABBA PhD program practical courses of the Cell cycle module GABBA PhD program (Doutoramento) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Distinctions

Award

2023 First prize for the best picture on "Cancer seen at the Microscope"
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022 CEEC 5th edition Assistant researcher
Fundação para a Ciência e a Tecnologia, Portugal
2019 Avrith Travel Award
2011 FCT Post-doc Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2009 Gulbenkian Institute for Science Travel Grant
Instituto Gulbenkian de Ciência, Portugal
2006 FCT PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2010 Award Investigador Tristão Mello-Sampayo