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I am a young researcher currently enrolled in the Structural Biochemistry PhD program at NOVA School of Science and Technology (FCT NOVA). I have a PhD studentship from FCT-MCTES to develop my project entitled “Engineering mucin-1 O-glycodomains to block aberrant interactions between tumour-glycans and lectins” between (Bio)Molecular Structure and Interactions by NMR Lab (UCIBIO, FCT NOVA; supervisor: Filipa Marcelo) and Sandra van Vliet’s Group (VU University Medical Center, Amsterdam, Netherlands; co-supervisor: Sandra van Vliet). I graduated in Biochemistry (BSc) from FCT NOVA in 2019 with a final grade of 18 out of 20. For that reason, I was awarded with a merit scholarship by the Department of Chemistry of FCT NOVA. During my BSc I performed two short internships in two different research labs: (Bio)Molecular Structure and Interactions by NMR Lab at FCT NOVA, under the supervision of Prof. Eurico Cabrita and Dr Jorge Dias; and the Cell Signalling in Drosophila lab at ITQB NOVA, under the guidance of Dr Pedro Domingos and Dr Fátima Cairrão. For my final BSc project (one semester), I returned to the (Bio)Molecular Structure and Interactions by NMR Lab at FCT NOVA under the supervision of Dr Filipa Marcelo to perform a project entitled "Enzymatic synthesis and structural analysis of MUC1 glycopeptides aberrantly expressed in cancer". Recently, part of my work was included in an open-access publication in the J. Am. Chem. Soc. (JACS Au, 2022, 2, 631-645). From September 2019 to January 2022, I accomplished my MSc at FCT NOVA in the Biochemistry program, finishing with a grade of 19 out of 20. My MSc dissertation was evaluated with the maximum grade of 20. For that achievement, I was awarded by FCT NOVA the distinctions of “Best student in the Master in Biochemistry from FCT NOVA in 2020/2021” and “Best student from FCT NOVA in 2020/2021”, and by DGES-Portugal I was awarded a Merit scholarship. Given my interest in the glycochemistry and glycobiology fields, I decided to accomplish my master thesis investigating the molecular recognition of sialic acid containing glycoconjugates by Siglecs using NMR spectroscopy. Benefiting from a short-term scientific mission (STSM) of COST Action Glyconanoprobes, during my thesis work I had the opportunity to perform a three-week internship at the Chemical Glycobiology lab at CICbioGUNE (Bilbao, Spain) led by Prof Dr Jiménez-Barbero to be trained in the expression and purification protocols for Siglecs. During my MSc I also got the chance to be a first author of a review article focused on the use of NMR and molecular modelling techniques to study the molecular recognition of sialic acids by siglecs, viruses and bacteria (Front. in Mol. Biosc. 2021, 8, 727847). Moreover, I had the opportunity to communicate my thesis results in two specialized international conferences with a poster communication in the "10th GERMN biennial NMR meeting & 9th IberoAmerican NMR meeting & 7th Iberian NMR meeting"; and with a flash presentation in the "6th Latin American Glycobiology Congress". Part of my work was integrated in a journal article on Nature Communications (Nat Comm, 2023, 14, 1). Between my master’s program and my PhD project (February-September 2022) I worked as a research fellow in the project of Dr Helena Coelho “Interrogating Salmonella/host-glycans crosstalk: Structure-functional approach”. Since then I have been participating in several courses and conferences under the structural biochemistry and glycobiology fields.
Identification

Personal identification

Full name
Cátia Alexandra Oliveira Soares
Date of birth
1998/02/07
Gender
Female

Citation names

  • Oliveira Soares, Cátia

Author identifiers

Ciência ID
9812-5372-A67E
ORCID iD
0000-0002-9102-3018

Email addresses

  • ca.soares@campus.fct.unl.pt (Professional)

Addresses

  • Campus de Caparica, 2829-516, Caparica, Almada, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022/10/01 - 2026/10/01
Ongoing
Bioquímica (Doutoramento)
Major in Structural Biochemistry
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Amsterdam UMC Locatie VUmc, Netherlands

NOVA School of Science and Technology - Departamento de Química, Portugal
"Engineering mucin-1 O-glycodomains to block aberrant interactions between tumour-glycans and lectins" (THESIS/DISSERTATION)
2023/09/25 - 2023/09/28
Concluded
First GLYCOTwinning Summer School: Hands-on course in protein/glycan interactions: a structural perspective (Outros)
NOVA School of Science and Technology - Departamento de Química, Portugal
2023/06/05 - 2023/06/07
Concluded
Structural Glycoscience Summer School 2023 (Outros)
Glyco@Alps, Portugal
2022/06/08 - 2022/06/10
Concluded
First Summer School in Biomedical Glycoscience (Outros)
Carbohydrate Group of the Spanish Royal Society of Chemistry, Spain
2019/09/16 - 2022/01/17
Concluded
Bioquímica (Mestrado integrado)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Decoding the molecular recognition of sialic acid-containing glycans by Siglecs" (THESIS/DISSERTATION)
19
2021/12
Concluded
Advanced NMR Spectroscopy (Outros)
Université de Lille, France
100%
2021/05/21
Concluded
Basics of Nuclear Magnetic Resonance (Outros)
Université de Lille, France
100%
2016/09/25 - 2019/06/21
Concluded
Bioquímica (Licenciatura)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Enzymatic synthesis and structural analysis of MUC1 glycopeptides aberrantly expressed in cancer" (THESIS/DISSERTATION)
18
2016/04 - 2018/01
Concluded
English course (Outros)
Wall Street English, Portugal
Affiliation

Science

Category
Host institution
Employer
2022/05/04 - Current Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Others

Category
Host institution
Employer
2021/10/04 - 2021/10/22 Internship in the Chemical Glycobiology Lab at CICbioGUNE through an STSM COST action (Prof Jesús Jiménez-Barbero and Dr. June Ereño-Orbea) CIC bioGUNE, Spain
European Cooperation in Science and Technology, Belgium
2018/08/06 - 2018/08/14 Internship at the Cell Signaling in Drosophila Lab (Dr. Pedro Domingos and Dr. Fátima Cairrão) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/07/09 - 2018/08/03 Internship at the (Bio)Molecular Structure and Interactions by NMR Lab (Prof. Eurico Cabrita and Dr. Jorge Dias) NOVA School of Science and Technology - Departamento de Química, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Projects

Grant

Designation Funders
2022/02 - 2022/09/30 Interrogating Salmonella/host-glycans crosstalk: Structure-functional approach
EXPL/QUI-OUT/0069/2021
Research Fellow
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Ongoing

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Oliveira Soares, Cátia; Laugieri, María Elena; Natale, Mariangela; Grosso, Ana Sofia; Coelho, Helena; Westerlind, Ulrika; Jiménez-Barbero, Jesús; et al. "Understanding the molecular basis of an anti-a2,6-Neu5Ac antibody recognition through an integrative structural approach". Paper presented in First GLYCOTwinning Summer School, 2023.
  2. Oliveira Soares, Cátia; Diniz, Ana; Travecedo, Maria; Grosso, Ana Sofia; Laugieri, María Elena; Barreira, Daniela F.; Coelho, Helena; et al. "Unveiling the Molecular Recognition of the sTn-Antigen by Immune-Related Receptors: A Structural Perspective". Paper presented in Structural Glycoscience Summer School (Grenoble, France) (Presented by Cátia O. Soares), 2023.
  3. Oliveira Soares, Cátia; Diniz, Ana; Travecedo, Maria; Grosso, Ana Sofia; Coelho, Helena; Barreira, Daniela F.; Videira, Paula Alexandra Quintela; et al. "Molecular recognition of sTn glycostructures by immune-related receptors". Paper presented in 14th International Meeting of the Portuguese Carbohydrate Group ¿ GLUPOR 14 (Caparica, Portugal) (Presented by Cátia O. Soares), 2023.
  4. Marlene Leite; Oliveira Soares, Cátia; Palma, Angelina S.; Dias, Jorge S; Marcelo, Filipa; Coelho, Helena. Corresponding author: Coelho, Helena. "Salmonella/host-glycans crosstalk: Structural perspective". Paper presented in 14 th International Meeting of the Portuguese Carbohydrate Group ¿ GLUPOR 14 Caparica (Portugal), 2023.
  5. Oliveira Soares, Cátia; Sena, Natasha; Pinheiro, Benedita; Palma, Angelina S.; Marcelo, Filipa; Coelho, Helena. Corresponding author: Coelho, Helena. "Molecular recognition of host-glycans by fimbrial adhesins of Salmonella Typhimurium". Paper presented in Biochemistry Global Summit (IUBMB-FEBS-PABMB 2022) (Presented by Cátia O. Soares), 2022.
  6. Oliveira Soares, Cátia; Sena, Natasha; Pinheiro, Benedita; Palma, Angelina S.; Marcelo, Filipa; Coelho, Helena. Corresponding author: Coelho, Helena. "Decoding the adhesion step of Salmonella Typhimurium to host-glycans". Paper presented in First Summer School in Biomedical Glycoscience (Jaca, Spain) (Presented by Cátia O. Soares), 2022.
  7. Oliveira Soares, Cátia; Coelho, Helena; Pia Lenza, Maria; Oyenarte, Iker; Ereño-Orbea, June; Jiménez-Barbero, Jesús; Marcelo, Filipa. "Decoding the molecular recognition of sialic-containing glycans by Siglecs immunomodulatory lectins". Paper presented in 10th GERMN biennial NMR meeting & 9th IberoAmerican NMR meeting & 7th Iberian NMR meeting (Presented by Cátia O. Soares), 2021.
  8. Oliveira Soares, Cátia; Coelho, Helena; Marcelo, Filipa; Ereño-Orbea, June; Jiménez-Barbero, Jesús. "Decoding the molecular recognition of sialic-containing glycans by Siglecs immunomodulatory lectins". Paper presented in Olimpíadas Universitárias da Bioquímica - EEC19 (Presented by Cátia O. Soares), 2021.
Journal article
  1. Atxabal, Unai; Nycholat, Corwin; Pröpster, Johannes M.; Fernández, Andrea; Oyenarte, Iker; Lenza, Maria Pia; Franconetti, Antonio; et al. "Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectroscopy and Molecular Dynamics Modeling". ACS Chemical Biology 19 2 (2024): 483-496. http://dx.doi.org/10.1021/acschembio.3c00664.
    10.1021/acschembio.3c00664
  2. Lenza, Maria Pia; Egia-Mendikute, Leire; Antoñana-Vildosola, Asier; Oliveira Soares, Cátia; Coelho, Helena; Corzana, Francisco; Bosch, Alexandre; et al. "Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-39119-8.
    Published • 10.1038/s41467-023-39119-8
  3. Coelho, Helena; de la Rivas, Matilde; Grosso, Ana Sofia; Diniz, Ana; Oliveira Soares, Cátia; Francisco, Rodrigo Almeida; Dias, Jorge S; et al. Corresponding author: Marcelo, Filipa. "Atomic and specificity details of mucin 1 O-glycosylation process by multiple polypeptide GalNAc-transferase isoforms unveiled by NMR and molecular modeling". JACS Au (2022): https://pubs.acs.org/doi/10.1021/jacsau.1c00529.
    Open access • Published
  4. Oliveira Soares, Cátia; Grosso, Ana Sofia; Ereño-Orbea, June; Coelho, Helena; Marcelo, Filipa. Corresponding author: Marcelo, Filipa. "Molecular recognition insights of sialic acid glycoconjugates by distinct receptors unveiled by NMR and molecular modelling". Frontiers in Molecular Biosciences 8 (2021): 1002. https://www.frontiersin.org/articles/10.3389/fmolb.2021.727847/full.
    Open access • Published
Thesis / Dissertation
  1. "Decoding the molecular recognition of sialic acid-containing glycans by Siglecs". Master, Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, 2022. http://hdl.handle.net/10362/132001.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/08/28 STSM Experience: Expression and Purification of Siglecs for Structural Studies (Flash presentation presented by Cátia O. Soares) Final Meeting COST ACTION 18132
Maynooth University (Maynooth, Ireland)
2023/01/17 Molecular recognition of sTn glycostructures by immune-related receptors (Flash presentation by Cátia O. Soares) 14th International Meeting of the Portuguese Carbohydrate Group – GLUPOR 14
Portuguese Carbohydrate Group from Sociedade Portuguesa de Química (Caparica, Portugal)
2021/10/06 Insights into the molecular recognition of natural sialoglycans by Siglecs using NMR spectroscopy (Presented by Cátia O. Soares) 6th Latin American Glycobiology Congress
Latin American Society of Glycobiology (México City - ONLINE, Mexico)
2021/02/12 Decoding the molecular recognition of sialic-containing glycans by Siglecs immunomodulatory lectins (Presented by Cátia O. Soares) Jornadas Intercalares das Dissertações Anuais dos Mestrados dos Departamentos de Química e de Ciências da Vida da FCT-NOVA
NOVA School of Science and Technology (Caparica, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2022/11/15 - 2023/06/05 Organizing committee at the 3rd Meeting of Young Biophysicists "Biophysics Festival 2023" (i3S, Porto, Portugal) (2023/06/01 - 2023/06/02)
Meeting (Member of the Organising Committee)
2022/12/15 - 2023/01/18 Member of the student organizing committee at the 14th International Meeting of the Portuguese Carbohydrate Group - GLUPOR 14 (Caparica, Portugal) (2023/01/16 - 2023/01/18)
Conference (Member of the Organising Committee)
NOVA School of Science and Technology - Departamento de Química, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/04/27 - Current Volunteer staff at the NMR facility at EXPO FCT (Faculty open day)
2021/05/26 - 2021/05/28 Attendance without communication
Symposium
European Chemical Biology Symposium 2021
EuChemS, Belgium

EU-OPENSCREEN ERIC, Germany
2020/12/07 - 2020/12/08 Attendance without communication
Meeting
EUROMAR, A European Magnetic Resonance Meeting
CIC bioGUNE, Spain
2018/02/24 - 2018/02/24 Attendance without communication
Workshop
VIII SPB Clinical Biochemistry Workshop about Allergy and Environment
Universidade de Évora, Portugal
2018/02/08 - 2018/02/08 Participation in a workshop about "Nanomaterials' toxicity in aquatic organisms", lectured by Prof. Mário Diniz
Workshop
JorTEC de Bioquímica 2018
NOVA School of Science and Technology - Departamento de Química, Portugal
2018/02/06 - 2018/02/06 Participation in a Molecular Gastronomy Workshop
Workshop
JorTEC de Bioquímica 2018
NOVA School of Science and Technology - Departamento de Química, Portugal
2017/11/06 - 2017/11/09 Attendance and staff help
Conference
2nd International Conference on Pollutant Toxic Ions and Molecules” (PTIM2017)
Associação Científica Proteomass, Portugal
2017/09/04 - 2017/09/07 Attendance and staff help
Symposium
3rd International Symposium in Profiling” (ISPROF2017)
Associação Científica Proteomass, Portugal
2016/07/06 - 2016/07/08 Participation in the 2016 MathIngenious Summer School with the theme "Math and life"
Other
MathIngenious Summer School
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Mentoring / Tutoring

Topic Student name
2022/02/01 - 2022/07 Molecular recognition studies of a Salmonella lectin-adhesin by NMR Natasha Sena Rodrigues (BSc student)
Distinctions

Award

2022 Best student in the Master in Biochemistry from FCT NOVA in 2020/2021
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 Best student from FCT NOVA in 2020/2021
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 Merit scholarship from DGES Portugal, from the academic year 2020/2021
Direção-Geral do Ensino Superior, Portugal
2021 Award Grant for Short Term Scientific Mission (COST Action: CA18132)
European Cooperation in Science and Technology, Belgium
2019 Merit Award offered by the Chemistry Department of FCT NOVA to the best student who completed the 1st Cycle in the 2018-2019 academic year and who continues to be enrolled in one of the Masters offered by the Chemistry Department the following year.
NOVA School of Science and Technology - Departamento de Química, Portugal
2016 Best student graduated in 2016 in a Science-Humanities course at the Alfredo dos Reis Silveira Secondary School
Alfredo dos Reis Silveira Secondary School, Portugal