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Samuel Gonçalves graduated in 2015 in Applied Biology from the University of Minho and received a MSc in Health Sciences from the same University in 2017. Between 2018 and early 2023 he developed his PhD thesis in Health Sciences, focused on the metabolic and genetic regulation of antifungal immunity, at the Life and Health Sciences Research Institute (ICVS) of the University of Minho in Dr. Agostinho Carvalho lab. Currently, he is a Junior Researcher focused on the elucidation of the effects of interindividual genetic variation on molecular and cellular processes of immunity and inflammation, and on translating this information into personalized medical interventions for fungal disease. His track record is currently mirrored by 25 publications in international peer-reviewed journals (>550 citations and h-index=11, ISI Web of Knowledge, October 2025) and 4 book chapters. From these, 19 publications were published in the last five years, 7 of which as the first author. Selected publications include first authorship in papers published in Nat Commun 2020, mBio 2021, Microbiol Spectr 2022, besides relevant collaborations published in JACI 2017, Nat Commun 2018, Thorax 2022, Redox Biology 2022, and Lancet Respir Med 2022. He has been participating in the teams of multiple research projects on the host-fungus interaction, including past and ongoing grants funded by the EU, "la Caixa" Foundation, FCT, Gilead Sciences, and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID). He has delivered several talks at international meetings, namely the Meeting of the British Society for Medical Mycology, 9th Advances Against Aspergillosis (AAA), and the Annual Meetings of the Portuguese Society for Immunology (SPI), in which he has received relevant awards. He is currently supervising undergraduate students, namely BSc students in Applied Biology and Biochemestry and the lab rotation of MD students. He is also member of the scientific council of ICVS.
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Identification

Personal identification

Full name
SAMUEL MARTINS GONÇALVES

Citation names

  • GONÇALVES, SAMUEL MARTINS

Author identifiers

Ciência ID
971F-012F-7257
ORCID iD
0000-0001-5056-4718

Email addresses

  • d7919@med.uminho.pt (Professional)
  • sam.mg9@hotmail.com (Personal)

Telephones

Telephone
  • 253604844 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Clinical Medicine - Hematology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Elementary (A2) Intermediate (B1) Beginner (A1) Elementary (A2)
Education
Degree Classification
2018/11/01 - 2023/01/10
Concluded
 Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"Metabolic regulation of antifungal immunity: from basic mechanisms to clinical translation" (THESIS/DISSERTATION)
 Approved
2015/09/01 - 2017/07/03
Concluded
 Ciências da Saúde (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"Translating the host-microbiota interaction into risk assessment of invasive aspergillosis" (THESIS/DISSERTATION)
 18
2012/09/01 - 2015/07/23
Concluded
 Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"O papel da ativação dos inflamassomas na resposta imunitária à infeção" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2023/01/13 - Current Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/11/01 - 2022/12/31 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018 Researcher (Research) Universidade do Minho, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Grant

Designation Funders
2025/09/01 - 2027/08/31 Dissecting cholesterol-mediated mechanisms of antifungal immunity in invasive pulmonary aspergillosis
ID3047
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 European Society of Clinical Microbiology and Infectious Diseases
Ongoing
2025/02/17 - 2026/08/16 Lipid Metabolism-Mediated Mechanisms of Immunity in Respiratory Fungal Disease
2023.12771.PEX
10.54499/2023.12771.PEX
Principal investigator
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/11 - 2022/12 Metabolic regulation of antifungal immunity: from basic mechanisms to clinical translation
SFRH/BD/136814/2018
PhD Student Fellow
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2024/10/01 - 2030/09/30 A High-Resolution Functional Genomics Approach to Define Susceptibility Pathways to Fungal Disease
2023.07620.CEECIND/CP2841/CT0022
10.54499/2023.07620.CEECIND/CP2841/CT0022
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 ICVS/3B’s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
10.54499/LA/P/0050/2020
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/12 - 2025 Immunometabolic regulation of granulomatous inflammation in sarcoidosis
PTDC/MED-OUT/1112/2021
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2023/01 - 2023/09/30 Metabolic control of immune cell function in respiratory fungal disease
2022.06674.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2023/01 - 2023/09 TRANS-CPA: A transdisciplinary approach to the identification of personalized biomarkers and therapeutic targets for chronic pulmonary aspergillosis
LCF/PR/HR17/52190003
Post-doc
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluded
2016 - 2020 The role of inflammasome-autophagy crosstalk in fungal infection
IF/00735/2014
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2019 The genetic architecture of the immune response to Aspergillus fumigatus: from biological understanding to therapeutic intervention
Mérieux Research Grant 2017
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Institut Mérieux
Concluded
2017 - 2019 The genetic architecture of the immune response to Aspergillus fumigatus: from biological understanding to therapeutic intervention
ESCMID Research Grant 2017
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 European Society of Clinical Microbiology and Infectious Diseases
Concluded
2017 - 2018 PTX3-mediated innate regulation of inflammation in sarcoidosis
2CA-Braga Grant 2016
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 2CA-Braga
Concluded
Outputs

Publications

Book chapter
  1. Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Cunha, Cristina; Carvalho, Agostinho. "The Lung Microbiome, Metabolome, and Breath Volatolome in the Diagnosis of Pulmonary Disease". In Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications, 297-305. Elsevier, 2019.
    10.1016/b978-0-12-815249-2.00031-2
  2. Cunha, Cristina; Gonçalves, Samuel M.; Carvalho, Agostinho. "Role of Deficits in Pathogen Recognition Receptors in Infection Susceptibility". In Management of Infections in the Immunocompromised Host, 115-131. Springer International Publishing, 2018.
    10.1007/978-3-319-77674-3_6
  3. Campos, Cláudia F.; van de Veerdonk, Frank L.; Gonçalves, Samuel M.; Cunha, Cristina; Netea, Mihai G.; Carvalho, Agostinho. "Host Genetic Signatures of Susceptibility to Fungal Disease". In Current Topics in Microbiology and Immunology, 237-263. Springer International Publishing, 2018.
    10.1007/82_2018_113
  4. Cunha, C.; Gonçalves, S.M.; Carvalho, A.. "Host-derived biomarkers for risk assessment of invasive fungal diseases". 2017.
    10.1007/978-1-4939-6515-1_7
Conference abstract
  1. Feys, S.; Gonçalves, S.M.; Khan, M.; Choi, S.; Boeckx, B.; Chatelain, D.; Cunha, C.; et al. "Influenza versus COVID-19-associated pulmonary aspergillosis: Profiling lower respiratory tract epithelial and myeloid innate immunity in patient samples". Paper presented in 21st Congress of the International Society for Human and Animal Mycology, New Delhi, 2022.
  2. Cunha, C.; Goncalves, S. M.; Campos, C. F.; Carvalho, A. "New insights in diagnosis and immunopathology of aspergillosis". Paper presented in 20th Congress of the International Society for Human and Animal Mycology (ISHAM), Amesterdam, 2018.
  3. Lupiañez, C.B..; Martínez-Bueno, M.; Sanchez-Maldonado, J.; Cunha, C.; Springer, J.; Lackner, M.; Ríos-Tamayo, R.; et al. "An Immunochip-based approach identifies ARTN2 and CX3CR1 as new risk loci for invasive aspergillosis in high risk hematological patients". Paper presented in The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation, Lisbon, 2018.
  4. Goncalves, S. M.; Lagrou, K.; Godzien, J.; Gabaldon, T.; Barbas, C.; Maertens, J. A.; Cunha, C.; Carvalho, A. "The microbiome-metabolome crosstalk in the pathogenesis of invasive aspergillosis". Paper presented in 8th Trends in Medical Mycology (TIMM), Belgrade, 2017.
Conference poster
  1. Fernandes R, Gonçalves SM, Silva-Gomes R, Caldeira I, Fernándes-Garcia M, Barbas C, Rodrigues F, Cunha C, Carvalho A. "Itaconate deficiency enhances anti-fungal effector functions of macrophages and confers resistance to infection with Aspergillus fumigatus". Paper presented in XLVIII SPI Annual Meeting, 2023.
  2. Caldeira I, Silva-Gomes R, Gonçalves SM, Fernandes R, Dinarello CA, van de Veerdonk FL, Cunha C, Carvalho A. "Genetic variation in IL-37 influences the immune response to Aspergillus fumigatus and predisposes to fungal disease after stem-cell transplantation". Paper presented in XLVIII SPI Annual Meeting, 2023.
  3. Santos RF, Coelho AL, Rufo JC, Coelho D, Gonçalves M, Gonçalves SM, Cunha C, Carvalho A, Delgado L, Morais A, Saraiva M,. "Comprehensive assessment of environmental fungus-reactive T cells response in hypersensitivity pneumonitis patients". Paper presented in XLVIII SPI Annual Meeting, 2023.
  4. Rita Silva-Gomes; Antunes D; Caldeira, Inês; GONÇALVES, SAMUEL MARTINS; Ana R. Fernandes; Rodrigues, Fernando; Barbas C; Cunha, Cristina; Carvalho, Agostinho. "PTX3 regulates macrophage effector function by modulating the intracellular carbon flux in response to A. fumigatus". Paper presented in XLVIII Annual Meeting of the Portuguese Society of Immunology, 2023, 2023.
  5. Antunes D, Aimanianda V, Duarte-Oliveira C, Gonçalves SM, Cunha C, Carvalho A. "The role of Pentraxin-3 in the immunometabolic regulation of antifungal immunity". Paper presented in 9th Advances Against Aspergillosis, 2020.
  6. Duarte-Oliveira C, Ferreira S, Campos CF, Antunes D, Pereira MC, Gonçalves SM, Mantovani A, Cunha C, Carvalho A. "The role of PTX3 in innate regulation of antifungal immunity in chronic pulmonary aspergillosis". Paper presented in 9th Advances Against Aspergillosis, 2020.
  7. Gonçalves SM, Rodrigues CS, Duarte-Oliveira C, Campos CF, Torrado E, Rodrigues F, Silvestre R, van de Veerdonk FL, et al. "Metabolic Regulation of Antifungal Immunity through the Mevalonate Pathway". Paper presented in XLIV SPI Annual Meeting, 2018.
  8. Gonçalves SM, Lagrou K, Rodrigues CS, Campos CF, Bernal-Martínez L, Rodrigues F, Silvestre R, Alcazar-Fuoli L, et al.. "Evaluation of alveolar cytokines as biomarkers for invasive pulmonary aspergillosis in high-risk patients". Paper presented in 8th Advances Against Aspergillosis, 2018.
  9. Duarte-Oliveira C, Campos CF, Rodrigues CS, Gonçalves SM, Gaifem J, Barbosa AM, Ferreira CR, Castro AG, et al.. "IL-10 overexpression in vivo promotes susceptibility to aspergillosis by suppressing innate and adaptive pulmonary antifungal immunity". Paper presented in 8th Advances Against Aspergillosis, 2018.
  10. Bernal-Martínez L, Cunha C, Gonçalves SM, Mellado E, Lagrou K, Maertens JA, Carvalho A, Alcazar-Fuoli L. "Evaluation of the role of TREM1 in invasive pulmonary aspergillosis". Paper presented in 8th Advances Against Aspergillosis, 2018.
  11. Campos CF, Bastos HN, Sokhatska O, Duarte-Oliveira C, Rodrigues CS, Gonçalves SM, Rolo R, Garlanda C, Delgado L, et al.. "Regulação da inflamação na sarcoidose pela pentraxina-3 (PTX3)". Paper presented in IV Jornadas de Investigação Clínica e Inovação, 2017.
  12. Duarte-Oliveira C, Campos CF, Rodrigues CS, Gonçalves SM, Gaifem J, Mesquita I, Garlanda C, Castro AG, Torrado E, et al.. "Pentraxin-3 promotes IL-10-dependent immune protection to the opportunistic fungus Trichosporon asahii". Paper presented in XLIII SPI Annual Meeting, 2017.
  13. Gonçalves SM, Rodrigues CS, Campos CF, Duarte-Oliveira C, Gaifem J, van de Veerdonk FL, Campos A Jr., Lacerda JF, et al.. "Genetically-determined NLRP3 hyperactivation confers risk to fungal disease by compromising macrophage function". Paper presented in XLIII SPI Annual Meeting, 2017.
  14. Cunha C, Gonçalves SM, Duarte-Oliveira C, Leite L, Lagrou K, Lupiañez CB, Mesquita I, Gaifem J, Barbosa AM, et al.. "IL-10 overexpression predisposes to invasive aspergillosis by suppressing innate and adaptive pulmonary antifungal immunity". Paper presented in HFP2017 Advanced Lecture Course, 2017.
  15. Duarte-Oliveira C, Gonçalves SM, Rodrigues F, Garlanda C, Goldman GH, Mantovani A, Carvalho A, Cunha C. "The long pentraxin PTX3 regulates the pathogenic potential of Trichosporon asahii via differential induction of IL-10". Paper presented in HFP2017 Advanced Lecture Course, 2017.
  16. Gonçalves SM, Duarte-Oliveira C, Gaifem J, van de Veerdonk FL, Rodrigues F, Torrado E, Silvestre R, Netea MG, et al.. "An activating NLRP3 inflammasome mutation predisposes to fungal disease by impairing antifungal effector functions of macrophages". Paper presented in HFP2017 Advanced Lecture Course, 2017.
  17. Oliveira-Coelho A, Sasaki SD, Gonçalves SM, Matos D, Rodrigues F, Marques A, Campos Jr. A, Lacerda JF, Cunha C, Carvalho. "NLRP3 inflammasome hyperactivation impairs antifungal immunity and predisposes to fungal disease". Paper presented in XLI Annual Meeting of the Portuguese Society for Immunology, 2015.
Journal article
  1. Gonçalves, Samuel M; Leite, Luis; de Vasconcelos, Pedro; Pereira, Inês; Dewi, Intan M W; Mercier, Toine; Aerts, Robina; et al. "A Functional Polymorphism in IL-36ß Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis". The Journal of Infectious Diseases (2025): https://doi.org/10.1093/infdis/jiaf301.
    10.1093/infdis/jiaf301
  2. Feys, Simon; Cardinali-Benigni, Martina; Lauwers, Hanne Moon; Jacobs, Cato; Stevaert, Annelies; Gonçalves, Samuel M.; Cunha, Cristina; et al. "Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis". American Journal of Respiratory and Critical Care Medicine 210 10 (2024): 1230-1242. https://doi.org/10.1164/rccm.202401-0145oc.
    10.1164/rccm.202401-0145oc
  3. Vieira, Sara F.; Gonçalves, Samuel M.; Gonçalves, Virgínia M. F.; Tiritan, Maria E.; Cunha, Cristina; Carvalho, Agostinho; Reis, Rui L.; Ferreira, Helena; Neves, Nuno M.. "Evaluation of Echinacea purpurea Extracts as Immunostimulants: Impact on Macrophage Activation". Planta Medica 90 15 (2024): 1143-1155. https://doi.org/10.1055/a-2436-9664.
    10.1055/a-2436-9664
  4. Gonçalves, Samuel M.; Pereira, Inês; Feys, Simon; Cunha, Cristina; Chamilos, Georgios; Hoenigl, Martin; Wauters, Joost; van de Veerdonk, Frank L.; Carvalho, Agostinho. "Integrating genetic and immune factors to uncover pathogenetic mechanisms of viral-associated pulmonary aspergillosis". mBio (2024): http://dx.doi.org/10.1128/mbio.01982-23.
    10.1128/mbio.01982-23
  5. Afonso, Julieta; Barbosa-Matos, Catarina; Silvestre, Ricardo; Pereira-Vieira, Joana; Gonçalves, Samuel Martins; Mendes-Alves, Camille; Parpot, Pier; et al. "Cisplatin-Resistant Urothelial Bladder Cancer Cells Undergo Metabolic Reprogramming beyond the Warburg Effect". Cancers 16 7 (2024): 1418. http://dx.doi.org/10.3390/cancers16071418.
    10.3390/cancers16071418
  6. Feys, Simon; Vanmassenhove, Sam; Kraisin, Sirima; Yu, Karen; Jacobs, Cato; Boeckx, Bram; Cambier, Seppe; et al. "Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study". The Lancet Microbe (2024): http://dx.doi.org/10.1016/s2666-5247(23)00368-3.
    10.1016/s2666-5247(23)00368-3
  7. Antunes, Daniela; Gonçalves, Samuel M.; Matzaraki, Vasiliki; Rodrigues, Cláudia S.; Gonçales, Relber A.; Rocha, Joana; Sáiz, Jorge; et al. "Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus". Microbiology Spectrum 11 1 (2023): http://dx.doi.org/10.1128/spectrum.02256-22.
    10.1128/spectrum.02256-22
  8. Vieira, Sara F.; Gonçalves, Samuel M.; Gonçalves, Virgínia M. F.; Llaguno, Carmen P.; Macías, Felipe; Tiritan, Maria Elizabeth; Cunha, Cristina; et al. "Echinacea purpurea Fractions Represent Promising Plant-Based Anti-Inflammatory Formulations". Antioxidants 12 2 (2023): 425. http://dx.doi.org/10.3390/antiox12020425.
    10.3390/antiox12020425
  9. Feys, Simon; Heylen, Jannes; Carvalho, Agostinho; Van Weyenbergh, Johan; Wauters, Joost; Gonçalves, Samuel M.; Cunha, Cristina; et al. "A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis". Intensive Care Medicine (2023): http://dx.doi.org/10.1007/s00134-022-06958-w.
    10.1007/s00134-022-06958-w
  10. Matzaraki, Vasiliki; Beno, Alexandra; Jaeger, Martin; Gresnigt, Mark S.; Keur, Nick; Boahen, Collins; Cunha, Cristina; et al. "Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis". Redox Biology 55 (2022): 102391. http://dx.doi.org/10.1016/j.redox.2022.102391.
    10.1016/j.redox.2022.102391
  11. Feys, Simon; Gonçalves, Samuel M.; Khan, Mona; Choi, Sumin; Boeckx, Bram; Chatelain, Denis; Cunha, Cristina; et al. "S3.3d Influenza versus COVID-19-associated pulmonary aspergillosis: Profiling lower respiratory tract epithelial and myeloid innate immunity in patient samples". Medical Mycology 60 Supplement (2022): http://dx.doi.org/10.1093/mmy/myac072.s3.3d.
    10.1093/mmy/myac072.s3.3d
  12. Feys, Simon; Gonçalves, Samuel M; Khan, Mona; Choi, Sumin; Boeckx, Bram; Chatelain, Denis; Cunha, Cristina; et al. "Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study". The Lancet Respiratory Medicine (2022): http://dx.doi.org/10.1016/s2213-2600(22)00259-4.
    10.1016/s2213-2600(22)00259-4
  13. Gonçalves, Samuel M.; Cunha, Cristina; Carvalho, Agostinho. "Understanding the genetic basis of immune responses to fungal infection". Expert Review of Anti-infective Therapy 20 7 (2022): 987-996. http://dx.doi.org/10.1080/14787210.2022.2063839.
    10.1080/14787210.2022.2063839
  14. Gonçalves, Samuel M; Ferreira, Anaísa V; Cunha, Cristina; Carvalho, Agostinho. "Targeting immunometabolism in host-directed therapies to fungal disease". Clinical and Experimental Immunology 208 2 (2021): 158-166. http://dx.doi.org/10.1093/cei/uxab014.
    10.1093/cei/uxab014
  15. Gonçalves, Samuel M.; Antunes, Daniela; Leite, Luis; Mercier, Toine; Horst, Rob ter; Vieira, Joana; Espada, Eduardo; et al. "Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis". mBio 12 3 (2021): http://dx.doi.org/10.1128/mbio.00369-21.
    10.1128/mbio.00369-21
  16. Hérivaux, Anaïs; Willis, Jesse R; Mercier, Toine; Lagrou, Katrien; Gonçalves, Samuel M; Gonçales, Relber A; Maertens, Johan; et al. "Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients". Thorax 77 3 (2021): 283-291. http://dx.doi.org/10.1136/thoraxjnl-2020-216179.
    10.1136/thoraxjnl-2020-216179
  17. Bernal-Martínez, L; Gonçalves, SM; de Andres, B; Cunha, C; Gonzalez Jimenez, I; Lagrou, K; Mellado, E; et al. "TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis". Virulence 12 1 (2021): 570-583. http://dx.doi.org/10.1080/21505594.2021.1879471.
    10.1080/21505594.2021.1879471
  18. Hérivaux, Ana¿s; Gonçalves, Samuel M.; Carvalho, Agostinho; Cunha, Cristina. "Microbiota-derived metabolites as diagnostic markers for respiratory fungal infections". Journal of Pharmaceutical and Biomedical Analysis 189 (2020): 113473. http://dx.doi.org/10.1016/j.jpba.2020.113473.
    10.1016/j.jpba.2020.113473
  19. Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Aimanianda, Vishukumar; ter Horst, Rob; Leite, Luis; Mercier, Toine; et al. "Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-16120-z.
    10.1038/s41467-020-16120-z
  20. Lupiañez, C. B.; Martínez-Bueno, M.; Sánchez-Maldonado, J. M.; Badiola, J.; Cunha, C.; Springer, J.; Lackner, M.; et al. "Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis". Infection and Immunity 88 4 (2020): http://dx.doi.org/10.1128/iai.00882-19.
    10.1128/iai.00882-19
  21. Gresnigt, Mark S.; Cunha, Cristina; Jaeger, Martin; Gonçalves, Samuel M.; Malireddi, R. K. Subbarao; Ammerdorffer, Anne; Lubbers, Rosalie; et al. "Genetic deficiency of NOD2 confers resistance to invasive aspergillosis". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-04912-3.
    10.1038/s41467-018-04912-3
  22. Carvalho, A.; Duarte-Oliveira, C.; Gonçalves, S.M.; Campos, A.; Lacerda, J.F.; Cunha, C.. "Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges". Current Fungal Infection Reports 11 1 (2017): 16-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014543028&partnerID=MN8TOARS.
    10.1007/s12281-017-0272-y
  23. Gonçalves, S.M.; Lagrou, K.; Rodrigues, C.S.; Campos, C.F.; Bernal-Martínez, L.; Rodrigues, F.; Silvestre, R.; et al. "Evaluation of bronchoalveolar lavage fluid cytokines as biomarkers for invasive pulmonary aspergillosis in at-risk patients". Frontiers in Microbiology 8 NOV (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85035812846&partnerID=MN8TOARS.
    10.3389/fmicb.2017.02362
  24. Duarte-Oliveira, C.; Rodrigues, F.; Gonçalves, S.M.; Goldman, G.H.; arvalho, A.; Cunha, C.. "The cell biology of the Trichosporon-host interaction". Frontiers in Cellular and Infection Microbiology 7 APR (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85027457649&partnerID=MN8TOARS.
    10.3389/fcimb.2017.00118
  25. Cunha, C.; Gonçalves, S.M.; Duarte-Oliveira, C.; Leite, L.; Lagrou, K.; Marques, A.; Lupiañez, C.B.; et al. "IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity". Journal of Allergy and Clinical Immunology 140 3 (2017): 867-870.e9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019152778&partnerID=MN8TOARS.
    10.1016/j.jaci.2017.02.034
  26. Gonçalves, Samuel M.; Lagrou, Katrien; Duarte-Oliveira, Cláudio; Maertens, Johan A.; Cunha, Cristina; Carvalho, Agostinho. "The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases". Virulence 8 6 (2016): 673-684. http://dx.doi.org/10.1080/21505594.2016.1257458.
    10.1080/21505594.2016.1257458
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/03/31 Cholesterol metabolism regulates the effector function of macrophages in response to infection with Aspergillus fumigatus XLVIII Annual Meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Aveiro, Portugal)
2021/06/12 Calcium sequestration by fungal melanin reprograms macrophage metabolism toward glycolysis and antifungal immunity Mycology 2020
British Society for Medical Mycology (London, United Kingdom)
2021/06/12 Toward new insights into the role of the lung microbiota in invasive pulmonary aspergillosis Mycology 2020
British Society for Medical Mycology (London, United Kingdom)
2020/02 Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity 9th Advances Against Aspergillosis
(Lugano, Switzerland)
2019/05 Fungal melanin regulates antifungal immunity via calcium-mediated reprogramming of macrophage metabolism XLV SPI Annual Meeting
(Coimbra, Portugal)
2018/02 IL-10 overexpression in vivo promotes susceptibility to aspergillosis by suppressing innate and adaptive pulmonary antifungal immunity 8th Advances Against Aspergillosis
(Lisbon, Portugal)
2018/02 Evaluation of the role of TREM1 in invasive pulmonary aspergillosis 8th Advances Against Aspergillosis
(Lisbon, Portugal)
2018/02 IL-10 overexpression in vivo promotes susceptibility to aspergillosis by suppressing innate and adaptive pulmonary antifungal immunity 9th Advances Against Aspergillosis
British Society for Medical Mycology (Lisbon , Portugal)
2018 An Immunochip-based approach identifies ARTN2 and CX3CR1 as new risk loci for invasive aspergillosis in high risk hematological patients 44th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT 2018)
(Lisbon, Portugal)
2017/10 Translating the host-microbiota interaction into risk assessment of fungal diseases Mérieux Research Grant Meeting 2017
(Annecy, France)
2017/10 The microbiome-metabolome crosstalk in the pathogenesis of invasive aspergillosis 8th Trends in Medical Mycology (TIMM)
(Belgrade, Serbia)
2017/05 The long pentraxin PTX3 regulates the pathogenic potential of Trichosporon asahii via differential induction of IL-10 HFP2017 Advanced Lecture Course
(La-Colle-sur-Loup, France)
2017/05 The long pentraxin PTX3 regulates the pathogenic potential of Trichosporon asahii via differential induction of IL-10 FEBS Advanced Lecture Course on Human Fungal Pathogens
Federation of European Biochemical Societies

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - 2023 The role of cholestrol homeostasis in antifungal immunity
Supervisor of Maria Costa
 BSc in Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023 - 2023 The role of cholesterol metabolism in response to Aspergillus fumigatus infection
Supervisor of Raquel Gama
 Integrated MSc in Medicine (Mestrado) (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Committee member

Activity description
Role 		Institution / Organization
2023 - Current Scientific Council of ICVS, University of Minho
Member
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Distinctions

Award

2024 Maria de Sousa Award 2024
Fundação Bial, Portugal
2019 SPI travel grant
Sociedade Portuguesa de Imunologia, Portugal
2018 Best poster award (8th Advances Against Aspergillosis International Conference)
2017 FEMS Meeting Grant (HFP2017 Advanced Lecture Course)
Federation Of European Microbiological Societies, Netherlands
2017 SPI travel grant
Sociedade Portuguesa de Imunologia, Portugal
2017 Academic Merit Scholarship
Universidade do Minho, Portugal