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Celso A. Reis; Biologist, MSc in Oncobiology, and PhD in Human Biology (Medical Faculty of the University of Porto). Celso A. Reis is the Head of the Glycobiology in Cancer group at i3S/Ipatimup, University of Porto, where he leads an international multidisciplinary team. He is Professor at ICBAS (University of Porto) and affiliated Professor at Medical Faculty (University of Porto). He has published 241 peer-reviewed papers, with over 14600 citations and with H-index of 63 (Scopus). His publications include papers in journals such as: Cancer Cell, Nature Cell Biology, Int. J. Cancer, Cancer Research, Nature Reviews in Cancer, PNAS, JBC, JACS, BBA, Molecular Cellular Proteomics, Oncogene, Journal Clinical Investigation, among others, as well as international Patents. Celso A. Reis research focus on the role of glycosylation in human cancer. He has addressed the molecular mechanisms controlling glycosylation in cancer cell biology, more specifically the role of glycosyltransferases regulating the biosynthesis of glycans in cancer. These included the role of sialyltransferases leading to the biosynthesis of terminal sialylated glycan antigens expressed by cancer cells. Celso A. Reis has also contributed for seminal studies determining the role of these glycosylation modifications and the consequences to cancer cell biology, including the mechanisms regulating cancer invasion, metastasis and tumour glycoimmunology. Celso A. Reis has also contributed to the application of glycoconjugates as biomarkers in human cancer and pre-neoplastic lesions, and the application of novel unique therapeutic strategies, including monoclonal antibodies to the clinical setting. Currently, Celso A. Reis develop novel strategies to improve cancer diagnosis and prognosis, and specifically to be able to improve cancer treatment based on the identification of the glycans controlling cancer cell communication, glycans that can be used as markers for cancer patient stratification, as well as glycans and glycoconjugates that can be used as novel targets in advanced cancer therapy strategies. _____________________________________________________________________________________________________________ Celso Albuquerque Reis é Biólogo, com Mestrado em Oncobiologia, e Doutorado em Biologia Humana pela Faculdade de Medicina da Universidade do Porto. É Investigador principal no Instituto de Investigação e Inovação em Saúde da Universidade do Porto i3S / Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP). Professor afiliado na Faculdade de Medicina Universidade do Porto e Professor no Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto. Celso A. Reis publicou mais de 241 artigos científicos com mais de 14600 citações, h-index 63. As suas publicações incluem artigos em revistas científicas como: Cancer Cell, Nature Cell Biology, Int. J. Cancer, Cancer Research, Nature Reviews in Cancer, PNAS, JBC, JACS, BBA, Molecular Cellular Proteomics, Oncogene, Journal Clinical Investigation, entre outras, assim como Patentes internationais. Celso A. Reis actua nas áreas das Ciências Médicas e da Saúde com ênfase em Medicina Clínica (Oncologia) e na Medicina Básica (Oncobiologia e Química Médica). Celso A. Reis também desenvolve projectos na área da Biotecnologia Médica (Tecnologias que envolvem a Manipulação de Células e Anticorpos). No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica e tecnológica são: Glycobiology; Cancer Glycobiology; Oncobiology; Biomarkers; Monoclonal Antibodies; Complex Carbohydrates; Glycan Biosynthesis; Cellular engineering; Glycoengineering; Therapy Response; Glycoimmunology; and Novel therapeutic targets.
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Identification

Personal identification

Full name
Celso Albuquerque Reis
Gender
Male

Citation names

  • Reis, Celso
  • Reis C.A.
  • Celso Reis
  • Reis C.
  • Reis CA

Author identifiers

Ciência ID
971E-55AD-76C0
ORCID iD
0000-0002-0286-6639
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=cZCkiO8AAAAJ
Scopus Author Id
7103111131
Education
Degree Classification
2023/07/20 - 2023/07/21
Concluded
 Agregação /Habilitation (Título de Habilitação de Coordenação Científica)
Major in Biologia Molecular e Celular
Universidade do Porto, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Aproved
1999/01/01 - 2000/12/31
Concluded
 Post Doc at the laboratory of Prof. Henrik Clausen (Doctorat)
Major in Glycobiology, Glycosciences, Glycoproteomics
Københavns Universitet, Denmark

Faculty of Health Sciences, University of Copenhagen, Denmark, Denmark
1995 - 1998/10/12
Concluded
 Biologia Humana (Doutoramento)
Major in Oncobiologia
Universidade do Porto Faculdade de Medicina, Portugal
"Characterization of human mucins in non-neoplastic gastric tissues and in gastric carcinomas." (THESIS/DISSERTATION)
 Aprovado por unanimidade
1995 - 1998/10/12
Concluded
 Biologia Humana (Doutoramento)
Major in Oncobiologia
Universidade do Porto Faculdade de Medicina, Portugal
 Aprovado por unanimidade
1994/04 - 1994/10
Concluded
 Master training period (Master)
Major in Glycobiology in Cancer
Faculty of Health Sciences, University of Copenhagen, Denmark, Denmark
1991 - 1993
Concluded
 Mestrado em Oncobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
"Immunohistochemical study of mucins in neoplastic and non-neoplastic gastric tissues and production of polyclonal sera to gastric carcinoma mucins." (THESIS/DISSERTATION)
 Muito Bom por unanimidade
1991/10/16
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"-" (THESIS/DISSERTATION)
 17 val.
Affiliation

Science

Category
Host institution 		Employer
2015 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/01/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
(...)
2002/01/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2015 - 2017 Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015 - 2015 Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2009/09/01 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2005/01/01 - 2023/08/31 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2002/01/01 - 2015/08/31 Principal Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1999/01/01 - 2001/12/31 Post-Doc Faculty of Health Sciences, University of Copenhagen, Denmark, Denmark
Projects

Grant

Designation Funders
2018/07/26 - 2021/06/25 GLYcanMATRIX - Targeting the cancer cell and extracellular matrix glycan's dynamics for impairment of tumour progression
POCI-01-0145-FEDER-028489
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2012/03 - 2015/02 PYLORICIDAL - Engineered biomaterials with Helicobacter PYLORI bacteriCIDAL effect
121149
Provided by PTCRIS: 121149
 Fundação para a Ciência e a Tecnologia, I.P.
2011/04 - 2014/09 E-cadherin Post-Translational Modifications by N-glycosylation: a potential new mechanism of E-cadherin deregulation in cancer
Provided by PTCRIS: 111358
111358
 Fundação para a Ciência e a Tecnologia, I.P.
2007/09 - 2010/08 In vitro and in vivo manipulation of the expression of Sialyl Lewis X and E-cadherin in canine malignant mammary tumours.
65537
Provided by PTCRIS: 65537
 Fundação para a Ciência e a Tecnologia, I.P.
2005/09 - 2008/12 PYLORI L&EPS: Structural Characterisation of Lipo- and Exopolysaccharides from Helicobacter pylori - Establishment of the chemical and biochemical basis for the development of vaccines and for the understanding of the adhesion processes
Provided by PTCRIS: 56393
56393
 Fundação para a Ciência e a Tecnologia, I.P.
2005/07 - 2007/12 Identification of Glycosylation-associated genes induced by Helicobacter pylori in gastric cells: a glycomic approach.
56686
Provided by PTCRIS: 56686
 Fundação para a Ciência e a Tecnologia, I.P.
2004 - 2007 Molecular mechanisms of biosynthesis of sialylated cancer-associated mucin carbohydrate antigens in gastric carcinoma
AICR 05-088
 Association for International Cancer Research

Contract

Designation Funders
2024/01/01 - 2027/12/31 A training network on the design of precision therapeutics that target key glycan motifs implicated in cancer.
101119601
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Horizon Europe Excellent Science
Ongoing
2024/01/01 - 2027/12/31 Training for Organoids modelling Physiology and Pathology in the human gastrointestinal tract
101119911
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Horizon Europe Excellent Science
Ongoing
2021/03/01 - 2024/02/29 Lectina humana do tipo C presente em macrófagos um alvo para o desenvolvimento de novas terapias
FCT - 2020 - PTDC/QUI-OUT/2586/2020
Post-doc
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2021/03/01 - 2023/02/28 Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets
CCDRN-2021-FEDER-000051
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
2018/07/01 - 2021/12/31 Identificação de Novas Drogas Glicoespecíficos para Combater a Metástase de Células Cancerígenas
PTDC/MED-QUI/29780/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2021/09/30 GLYCANTIGENS .: Glicoantigénios da proteina MUC1: Um perspectiva estructural na luta contra o cancro
PTDC/BIAMIB/ 31028/2017
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/12/01 - 2021/07/25 Targeting the cancer cell and extracellular matrix glycan's dynamics for impairment of tumour progression
PTDC/MED-ONC/28489/2017
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Identification of Novel GlycoSpecific Drugs to Tackle Cancer Cell Metastasis
PTDC/MED-QUI/29780/2017
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
2018/07/01 - 2021/06/30 GastroCure - Bioactive Soybean and Cruciferous extracts towards application in gastrointestinal disorders: development, characterization and delivery
.
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/07/01 - 2020/03/31 GLICOENGENHARIA CELULAR PARA A AVALIÇÃO DAS MODIFICAÇÕES PÓS-TRADUCIONAIS DOS RECEPTORES CELULARES NO CANCRO: APLICAÇÕES NO DIAGNÓSTICO E TERAPIA
PTDC/BBB-EBI/0567/2014
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/06/30 Cellular glycoengineering for evaluation of post-translational modification of receptors in cancer
PTDC/BBB-EBI/ 0567/2014
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/06/01 - 2019/06/30 Gycosylation alterations in cancer cell invasion and metastasis.
NORTE-01-0145-FEDER-000029
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
2016/05/01 - 2019/06/30 Glycosylation of tyrosine kinase receptors as novel biomarkers for targeted therapy
NORTE-01-0145-FEDER-000029
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
2016/01 - 2018/12 CELLULAR GLYCOENGINEERING FOR EVALUATION OF POST-TRANSLATIONAL MODIFICATIONS OF RECEPTORS IN CANCER: THERAGNOSTIC APPLICATIONS
Provided by PTCRIS: 139174
 Fundação para a Ciência e a Tecnologia, I.P.
2016/06 - 2018/06 Human target validation of HS members in cancer
Pharmis IPATIMUP
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
PHARMIS BIOFARMACEUTICA, LTDA
Concluded
2016/06 - 2018/06 Human target validation of HS members in cancer
Pharmis IPATIMUP
 PHARMIS BIOFARMACEUTICA, LTDA
2016/03/01 - 2018/03/01 Glycosylation of Receptors in Gastric Cancer. Glicosilação de recetores em cancro gástrico: novos biomarcadores para uma terapia direcionada
FCT/DAAD Celso Reis
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2018 Glycosylation in gastric cancer receptors: Novel biomarkers for targeted therapy.
FCT/DAAD Celso Reis
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2017 Systems Glycobiology of Gastric Cancer; Gastric Glyco Explorer
316929
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
European Commission Seventh Framework Programme for Research and Technological Development People
Concluded
2013/01 - 2016/12 Role of differential glycosylation in Cancer Receptors and patients therapy response.
Merck project I3S/ IPATIMUP Celso Reis
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Merck KGaA
Concluded
2013/06 - 2015/09 Genetic Engineering for the characterization of the O-Glycoproteome of cancer cells / Engenharia genética com Zinc-finger nucleases para a caracterização do O-glicoproteoma das células do cancro.
PTDC/BBB-EBI/0786/2012
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/06 - 2015/05 Zinc-finger nuclease-glycoengineered SimpleCell lines for characterization of the O-glycoproteome of cancer cells.
Provided by PTCRIS: 125428
125428
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
2014 - 2015 “SWEETMIC: Helicobacter pylori entrapment using “sweet” microsponges: a new alternative for gastric infection treatment”
EXPL/CTMBIO/ 0762/2013
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015 PYLORICIDAL - Engineered biomaterials with Helicobacter PYLORI bacteriCIDAL effect
info:eu-repo/grantAgreement/FCT/COMPETE/121149/PT
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/12 - 2014/11 T cell receptor N-glycosylation as a new mechanism underlying Inflammatory Bowel Disease pathogenesis. Implications for therapy.
Provided by PTCRIS: 124445
124445
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2012 - 2014 Glycomic Approach to unravel the role of Glycostructures in Gastric Carcinogenesis
Research grant Celso Reis
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Institute Merieux
Concluded
2009/01 - 2012/03 Early detection of cancer using serum biomarkers based on aberrant post-translational modifications of O-glycoproteins, O-PTM-Biomarkers.
Provided by PTCRIS: 82716
82716
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2008/03 - 2011/08 A strategy for preventing H. pylori-associated gastric cancer based on materials with specific receptors to the bacteria - from SAMs to Gly-R chitosan microspheres
Provided by PTCRIS: 65330
65330
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Outputs

Publications

Book
  1. Dias, A.M.; Almeida, C.R.; Reis, C.A.; Pinho, S.S.. Studying T cells N -glycosylation by imaging flow cytometry. 2016.
    10.1007/978-1-4939-3302-0_11
  2. Reis, C.A.; Magalhães, A.. Glycosyltransferases and gastric cancer. 2016.
    10.1007/978-4-431-55939-9_2
  3. Pinho, S.S.; Reis, C.A.. E-Cadherin Glycosylation in Cancer. 2015.
    10.1007/978-4-431-54841-6_54
  4. Gomes, J.; Reis, C.A.. Immunodetection of glycosyltransferases in gastrointestinal tissues. 2013.
    10.1007/978-1-62703-465-4-26
  5. Osório, H.; Reis, C.A.. Mass spectrometry methods for studying glycosylation in cancer. 2013.
    10.1007/978-1-62703-392-3-13
  6. Pinho, S.S.; Carvalho, S.; Cabral, J.; Reis, C.A.; Gärtner, F.. Canine carcinogenesis in translational cancer research. 2012.
Journal article
  1. Marta Baptista Freitas; Irene Gullo; Dina Leitão; Lúcia Águas; Carla Oliveira; António Polónia; Joana Gomes; et al. "HER2 and PD-L1 Expression in Gastric and Gastroesophageal Junction Cancer: Insights for Combinatorial Targeting Approaches". Cancers (2024): https://doi.org/10.3390/cancers16061227.
    10.3390/cancers16061227
  2. Álvaro M. Martins; Tânia M. Lopes; Francisca Diniz; José Pires; Hugo Osório; Filipe Pinto; Daniela Freitas; Celso A. Reis. "Differential Protein and Glycan Packaging into Extracellular Vesicles in Response to 3D Gastric Cancer Cellular Organization". Advanced Science (2023): https://doi.org/10.1002/advs.202300588.
    10.1002/advs.202300588
  3. Juliana Poças; Catarina Marques; Catarina Gomes; Andreia H Otake; Filipe Pinto; Mariana Ferreira; Tiago Silva; et al. "Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival". Proceedings of the National Academy of Sciences 120 20 (2023): http://dx.doi.org/10.1073/pnas.2214853120.
    10.1073/pnas.2214853120
  4. Ana F. Costa; Emanuel Senra; Isabel Faria-Ramos; Andreia Teixeira; João Morais; Mariana Pacheco; Celso A. Reis; Catarina Gomes. "ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility". Glycoconjugate Journal (2023): https://doi.org/10.1007/s10719-023-10113-y.
    10.1007/s10719-023-10113-y
  5. Francisca Diniz; Maria Azevedo; Flávia Sousa; Hugo Osório; Diana Campos; Paula Sampaio; Joana Gomes; Bruno Sarmento; Celso A. Reis. "Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions". Materials Today Bio 16 (2022): 100417-100417. http://dx.doi.org/10.1016/j.mtbio.2022.100417.
    10.1016/j.mtbio.2022.100417
  6. Catarina Marques; Juliana Poças; Catarina Gomes; Isabel Faria-Ramos; Celso A. Reis; Romain R. Vivès; Ana Magalhães. "Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion". Journal of Biological Chemistry (2022): https://doi.org/10.1016/j.jbc.2022.102546.
    10.1016/j.jbc.2022.102546
  7. Henrique O. Duarte; Celso A. Reis; Joana Gomes. "Insights on ErbB glycosylation – contributions to precision oncology". Trends in Cancer 8 6 (2022): 448-455. https://doi.org/10.1016/j.trecan.2022.02.003.
    10.1016/j.trecan.2022.02.003
  8. Francisca Diniz; Pedro Coelho; Henrique O. Duarte; Bruno Sarmento; Celso A. Reis; Joana Gomes. "Glycans as Targets for Drug Delivery in Cancer". Cancers (2022): https://doi.org/10.3390/cancers14040911.
    10.3390/cancers14040911
  9. Rita Matos; Emily Taillieu; Sofie De Bruyckere; Chloë De Witte; Alexandra Rêma; Hugo Santos-Sousa; Jorge Nogueiro; et al. "Presence of Helicobacter Species in Gastric Mucosa of Human Patients and Outcome of Helicobacter Eradication Treatment". Journal of Personalized Medicine 12 2 (2022): 181-181. https://doi.org/10.3390/jpm12020181.
    10.3390/jpm12020181
  10. Flávia Pereira; Anabela Ferreira; Celso Albuquerque Reis; Maria João Sousa; Maria José Oliveira; Ana Preto. "KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications". Cells 11 3 (2022): 398-398. https://doi.org/10.3390/cells11030398.
    10.3390/cells11030398
  11. Rafaela Abrantes; Henrique O. Duarte; Catarina Gomes; Sébastien Wälchli; Celso A. Reis. "CAR-Ts: new perspectives in cancer therapy". FEBS Letters (2022): https://doi.org/10.1002/1873-3468.14270.
    10.1002/1873-3468.14270
  12. João L. Pereira; Patrícia Cavaco; Ricardo C. da Silva; Ivette Pacheco-Leyva; Stefan Mereiter; Ricardo Pinto; Celso A. Reis; Nuno R. dos Santos. "P-selectin glycoprotein ligand 1 promotes T cell lymphoma development and dissemination". Translational Oncology 14 8 (2021): 101125-101125. https://doi.org/10.1016/j.tranon.2021.101125.
    10.1016/j.tranon.2021.101125
  13. Ana Magalhães; Henrique O. Duarte; Celso A. Reis. "The role of O-glycosylation in human disease". Molecular Aspects of Medicine 79 (2021): 100964-100964. https://doi.org/10.1016/j.mam.2021.100964.
    10.1016/j.mam.2021.100964
  14. Filipe Pinto; Liliana Santos-Ferreira; Marta Pinto; Catarina Gomes; Celso Reis. "The Extracellular Small Leucine-Rich Proteoglycan Biglycan Is a Key Player in Gastric Cancer Aggressiveness". Cancers 13 6 (2021): 1330-1330. https://doi.org/10.3390/cancers13061330.
    10.3390/cancers13061330
  15. Joana G. Rodrigues; Henrique O. Duarte; Celso A. Reis; Joana Gomes. "Aberrant protein glycosylation in cancer: implications in targeted therapy". Biochemical Society Transactions (2021): https://doi.org/10.1042/BST20200763.
    10.1042/BST20200763
  16. Isabel Faria-Ramos; Juliana Poças; Catarina Marques; João Santos-Antunes; Guilherme Macedo; Celso A. Reis; Ana Magalhães. "Heparan Sulfate Glycosaminoglycans: (Un)Expected Allies in Cancer Clinical Management". Biomolecules (2021): https://doi.org/10.3390/biom11020136.
    10.3390/biom11020136
  17. Álvaro M. Martins; Cátia C. Ramos; Daniela Freitas; Celso A. Reis. "Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications". Cells 10 1 (2021): 109-109. https://doi.org/10.3390/cells10010109.
    10.3390/cells10010109
  18. Rita Matos; Kaori L. Fonseca; Stefan Mereiter; Ana Raquel Maceiras; Joana Gomes; Cristina Vilaplana; Fátima Gartner; et al. "Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium". Microorganisms 9 1 (2021): 99-99. https://doi.org/10.3390/microorganisms9010099.
    10.3390/microorganisms9010099
  19. Beatriz Leão; Xiaogang Wen; Henrique O. Duarte; Irene Gullo; Gilza Gonçalves; Patrícia Pontes; Claudia Castelli; et al. "Expression of Thomsen–Friedenreich Antigen in Colorectal Cancer and Association with Microsatellite Instability". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/3/1340.
    10.3390/ijms22031340
  20. Sara Amorim; Celso A. Reis; Rui L. Reis; Ricardo A. Pires. "Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials". Trends in Biotechnology (2021): https://doi.org/10.1016/j.tibtech.2020.06.003.
    10.1016/j.tibtech.2020.06.003
  21. Joana S. Paiva; Pedro A. S. Jorge; Rita S. R. Ribeiro; Meritxell Balmaña; Diana Campos; Stefan Mereiter; Chunsheng Jin; et al. "Author Correction: iLoF: An intelligent Lab on Fiber Approach for Human Cancer Single-Cell Type Identification". Scientific Reports (2020): https://doi.org/10.1038/s41598-020-67916-4.
    10.1038/s41598-020-67916-4
  22. Joana S. Paiva; Pedro A. S. Jorge; Rita S. R. Ribeiro; Meritxell Balmaña; Diana Campos; Stefan Mereiter; Chunsheng Jin; et al. "iLoF: An intelligent Lab on Fiber Approach for Human Cancer Single-Cell Type Identification". Scientific Reports (2020): https://doi.org/10.1038/s41598-020-59661-5.
    10.1038/s41598-020-59661-5
  23. Reis CA. "Analysis of the Effect of Increased a2,3-Sialylation on RTK Activation in MKN45 Gastric Cancer Spheroids Treated with Crizotinib". International Journal of Molecular Sciences (2020): http://dx.doi.org/10.3390/ijms21030722.
    10.3390/ijms21030722
  24. Reis CA. "Impact of Truncated O-glycans in Gastric-Cancer-Associated CD44v9 Detection". Cells (2020): http://dx.doi.org/10.3390/cells9020264.
    10.3390/cells9020264
  25. Sara Amorim; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires. "Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44". Journal of Materials Chemistry B (2020): https://doi.org/10.1039/D0TB00407C.
    10.1039/D0TB00407C
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  142. Mesquita, P.; Almeida, R.; Lunet, N.; Reis, C.A.; Silva, L.F.S.; Serpa, J.; Van Seuningen, I.; Barros, H.; David, L.. "Metaplasia - A transdifferentiation process that facilitates cancer development: The model of gastric intestinal metaplasia". Critical Reviews in Oncogenesis 12 1-2 (2006): 3-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749344533&partnerID=MN8TOARS.
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  146. Santos-Silva, F.; Fonseca, A.; Caffrey, T.; Carvalho, F.; Mesquita, P.; Reis, C.; Almeida, R.; David, L.; Hollingsworth, M.A.. "Thomsen-Friedenreich antigen expression in gastric carcinomas is associated with MUC1 mucin VNTR polymorphism". Glycobiology 15 5 (2005): 511-517. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944447993&partnerID=MN8TOARS.
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  148. Reis, C.; Carneiro, E.; Fonseca, J.; Pereira, P.; Vaz, R.; Pinto, R.; Capelinha, A.F.; Lopes, J.M.; Salgado, A.. "Epithelioid hemangioendothelioma and multiple thoraco-lumbar lateral meningoceles: Two rare pathological entities in a patient with NF-1". Neuroradiology 47 2 (2005): 165-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-15844387098&partnerID=MN8TOARS.
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  150. Marques, T.; David, L.; Reis, C.; Nogueira, A.. "Topographic expression of MUC5AC and MUC6 in the gastric mucosa infected by Helicobacter pylori and in associated diseases". Pathology Research and Practice 201 10 (2005): 665-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144481570&partnerID=MN8TOARS.
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  151. Serpa, J.; Mendes, N.; Reis, C.A.; Santos Silva, L.F.; Almeida, R.; Le Pendu, J.; David, L.. "Two new FUT2 (fucosyltransferase 2 gene) missense polymorphisms, 739G ¿ A and 839T ¿ C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal". Biochemical Journal 383 3 (2004): 469-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-9144251105&partnerID=MN8TOARS.
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  152. Nogueira, A.M.; Marques, T.; Soares, P.C.M.; David, L.; Reis, C.A.; Serpa, J.; Queiroz, D.M.; Rocha, G.A.; Rocha, A.C.. "Lewis antigen expression in gastric mucosa of children: Relationship with Helicobacter pylori infection". Journal of Pediatric Gastroenterology and Nutrition 38 1 (2004): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142576783&partnerID=MN8TOARS.
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  176. David, L.; Silva, F.; Seruca, R.; Pinto, M.; Reis, C.; Sobrinho-Simoes, M.; Jass, R.J.. "Correspondence re: A. E. Biemer-Huttmann et al., Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clin. Cancer res., 6: 1909-1916, 2000 (multiple letters)". Clinical Cancer Research 6 11 (2000): 4461-4462. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033739109&partnerID=MN8TOARS.
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  178. López-Ferrer, A.; De Bolós, C.; Barranco, C.; Garrido, M.; Isern, J.; Carlstedt, I.; Reis, C.A.; Torrado, J.; Real, F.X.. "Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epithelium". Gut 47 3 (2000): 349-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033862773&partnerID=MN8TOARS.
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Intellectual property

Licensing patent rights
  1. 2010. "Monoclonal antibody to the human mucin MUC5AC". United States.
    Assigned
  2. 2010. "Monoclonal antibody to the human mucin MUC6". United States.
    Assigned
Patent
  1. Reis CA. 2018. "WO2018217116 Detection and isolation of cancer cells from body fluids based on a glycosylation pattern and methods of use thereof".
    Granted/Issued

Other

Other output
  1. Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology. 2021. Nuno Brito Santos; Zoé Enderlin Vaz da Silva; Catarina Gomes; Celso A. Reis; Maria João Amorim. https://doi.org/10.1101/2021.02.16.431406.
    10.1101/2021.02.16.431406
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/11/29 The diversity and functionality of the cancer glycome: molecular mechanisms and clinical implications. Oslo University Hospital. Oslo, Norway. Seminar at Oslo University Hospital
(Norway)
2024/11/28 The Diversity and Functionality of the Cancer Glycome: from Molecular Mechanisms to the Clinical Applications. 7TH GLYCOBASQUE MEETING, Bilbao, Spain 7TH GLYCOBASQUE MEETING
(Spain)
2024/10/15 The role of glycosylation in gastric carcinogenesis and tumour progression: insights into patient-derived organoids models. Umea University, Sweden Seminar at Umea University, Sweden
(Sweden)
2024/09/23 The diversity and functionality of the cancer glycome: role in oncogenic processes and clinical implications. 16th BRATISLAVA SYMPOSIUM ON SACCHARIDES, Slovakia 16th BRATISLAVA SYMPOSIUM ON SACCHARIDES
(Slovakia)
2024/08/02 Glycobioloy in Cancer; LUSO-Ciência GOUVEIA 2024, Portugal
(Portugal)
2024/07/04 The role of glycosylation in gastric carcinogenesis and tumour progression: insights into patient-derived organoids models. The 15TH international workshop on pathogenesis and host response in helicobacter infections Helsingør, Denmark The 15TH international workshop on pathogenesis and host response in helicobacter infections
2024/06/14 The role of glycosylation in inflammation, gastric carcinogenesis and tumour progression Twinflag Twinning - CINBIO - University of Vigo, Spain
(Spain)
2024/06/06 The diversity and functionality of the cancer glycome: the role of sialylation in oncogenic processes and clinical implications SialoGlyco 2024 - Lille, France
2024/04/23 The diversity and functionality of the cancer glycome: from molecular mechanisms to the clinical applications. The Wistar Institute, Philadelphia, Pensilvania, USA
(Philadelphia, United States)
2024/04/17 The diversity and functionality of the cancer glycome: from molecular mechanisms to the clinical applications. EMBO Workshop "Trafficking and Glycosylation at the Golgi apparatus", Sorrento, Italy. EMBO Workshop "Trafficking and Glycosylation at the Golgi apparatus"
(Sorrento, Italy)
2024/01/15 The Diversity and Functionality of the Cancer Glycome: from Molecular Mechanisms to the Clinical Applications. 7th Iberian Carbohydrate Meeting, Jointly organized by the Carbohydrate Groups of the Real Sociedad Española de Química (RSEQ) and Sociedade Portuguesa de Química (SPQ), Sitges, Barcelona 7th Iberian Carbohydrate Meeting
(Sitges, Barcelona, Spain)
2023/10/11 Glycobiology in cancer: from the molecular mechanisms to the clinical applications. Invited seminar on-line: Universidad Nacional Córdoba, Argentina. Invited seminar on-line: Universidad Nacional Córdoba, Argentina.
Universidad Nacional Córdoba, Argentina. (Cordoba, Argentina)
2023/08/27 Altered Glycosylation in Cancer Affects Cellular Receptor Tyrosine Kinases and Regulates Cancer Cell Sensitivity to Therapeutic Drugs. 26th International Symposium on Glycoconjugates (Glyco26), Taipei, Taiwan. 26th International Symposium on Glycoconjugates
2023/07/09 Glycosylation in cancer affects cellular receptor tyrosine kinases and regulates cancer cell biology. The 21st European Carbohydrate Symposium Paris, France. The 21st European Carbohydrate Symposium
(France)
2023/06/20 The Diversity and Functionality of the Cancer Glycome: From Molecular Mechanisms to the Clinical Applications. Unparalleled Diversity and Functionality of the Glycome. Beilstein Glyco-Bioinformatics Symposium. 2023. Limburg, Lahn, Germany. Beilstein Glyco-Bioinformatics Symposium.
2022/11/04 Glycosylation in cancer: Glycans in personalized medicine and cancer patient stratification. The Human Glycome Project, Split, Croacia. The Human Glycome Project,
2022/11/03 Altered glycosylation in cancer: dissecting the molecular mechanism and understanding the clinical implications.1st Oncolille Days. Universidade de Lille, France. Oncolille Days. Universidade de Lille,
(France)
2022/08/25 Altered glycosylation in cancer: targeting the molecular mechanisms and understanding the clinical implications. Debrecen Colloquium on Carbohydrates 2022 and 2nd Meeting of the COST ACTION 18132 GLYCOnanoPROBES. Debrecen, Hungary. Debrecen Colloquium on Carbohydrates 2022
(Hungary)
2022/07/12 Deciphering the role of glycosylation in cancer: biological functions and implications for therapy. International Carbohydrate Symposium; On-line - São Paulo, Brazil International Carbohydrate Symposium
(Brazil)
2022/06/30 Glycosylation in cancer: dissecting the molecular mechanism and understanding the clinical implications. 5th Annual meeting of the Cost action Stratagem. Coimbra, Portugal. 5th Annual meeting of the Cost action Stratagem.
(Portugal)
2022/06/29 Altered glycosylation in cancer: dissecting the molecular mechanisms and understanding the clinical implications. Seminário convidado no UCBIO, Universidade Nova de Lisboa. Caparica, Portugal. Seminário convidado no UCBIO,
(Portugal)
2022/06/10 Glycosylation in cancer progression and metastasis. From biomarkers to therapeutics. Summer School in Biomedical Glycoscience. Jaca, Huesca, Espanha. Summer School in Biomedical Glycoscience.
(Spain)
2022/05/04 Glycosylation in cancer: molecular characterization and implications for cancer therapy. Innogly Cost Action Annual Meeting. Lugano, Switzerland. Innogly Cost Action Annual Meeting.
(Switzerland)
2022/03/28 Altered glycosylation in cancer: dissecting the molecular mechanism and understanding the clinical implications. Leiden University Medical Center. Leiden, Nethelands Seminar Leiden University Medical Center. Leiden, Nethelands
(Netherlands)
2021/12/10 Glycosylation in cancer: molecular characterization and implications for cancer therapy. Seminar at the National University of Ireland-Galway, Virtual presentation. Ireland. Seminar at the National University of Ireland-Galway,
(Ireland)
2021/10/05 Glycosylation in cancer: molecular characterization and implications for cancer therapy. 6th Latin American Glycobiology Meeting. Virtual presentation, Morelos, Mexico. 6th Latin American Glycobiology Meeting.
(Mexico)
2021/09/08 Altered glycosylation in cancer – insights for targeting tumor heterogeneity and novel targets. Oral presentation at the Seminar Program of the Department of Biochemistry Puerto Rico. School of Medicine; University of Puerto Rico. San Juan, PR, USA. Seminar Program of the Department of Biochemistry
Seminar Program of the Department of Biochemistry
2021/07/27 Glycobiology in health and diseases. Invited oral presentation at the Workshop of the São Paulo School of Advanced Science on Glycobiology. São Paulo, Brasil. . Invited oral presentation at the Workshop of the São Paulo School of Advanced Science on Glycobiology. São Paulo, Brasil.
São Paulo School of Advanced Science on Glycobiology. São Paulo, Brasil. (Brazil)
2021/04/21 Altered glycosylation in Cancer ¿ insights for targeting tumor heterogeneity and novel targets. Seminar at NOVA Medical School| Faculdade de Ciências Médicas da Universidade NOVA de Lisboa. Lisboa, Seminar at NOVA Medical School| Faculdade de Ciências Médicas da Universidade NOVA de Lisboa. Lisboa,
Seminar at NOVA Medical School| (Lisboa, Portugal)
2021/03/18 Altered glycosylation in Cancer - insights for targeting tumor heterogeneity and novel targets. Seminar at GSK _ GlaxoSmithKline. Siena, Italy Seminar at GSK – GlaxoSmithKline. Siena, Italy
GlaxoSmithKline. Siena, Italy (Siena, Italy)
2020/06/20 Altered glycosylation in Cancer: insights for targeting tumor heterogeneity and novel targets. 12th International Symposium on Glycosyltransferases 12th International Symposium on Glycosyltransferases
GlycoT (Boston, United States)
2019/10/28 Altered glycosylation in cancer - targeting tumor heterogeneity and therapeutic implications Invited Presentation at the 30th Joint Glycobiology Meeting 30th Joint Glycobiology Meeting
University of Lille (Lille, France)
2019/09/27 Altered Glycosylation in Cancer - diagnostic and therapeutic applications Der Deutschen Gesellschaft für Klinische Chemie und Laboratoriumsmedizin
Deutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin (Magdeburg, Germany)
2019/08/31 Cellular glycosylation: biosynthesis and functional implications in cancer 25th International Symposium on Glycoconjugates
International Glycoconjugate Symposium (Milan, Italy)
2017/12/04 Glycosylation in cancer: molecular functions and clinical applications International Union of Biochemistry and Molecular Biology (IUBMB) Meeting on Frontiers in Glycoscience - Oncology
International Union of Biochemistry and Molecular Biology (IUBMB) (Taipei, Taiwan)
2017/07/06 Glycosylation in Cancer: Glycomic strategies for characterization of molecular functions and biomarker applications. EUROCARB - 19 European Carbohydrate Symposium
European Carbohydrate Organisation (Barcelona, Spain)
2017/03/10 Glycosylation in cancer: mechanisms and clinical implications Invited seminar at Institute Pasteur. Paris
Institute Pasteur (Paris, France)
2016/09/14 Mapping the human glycome in health and disease. The human glycome
adcliffe Institute for Advanced Study, Harvard University, MA, USA (Cambridge MA USA, United States)
2016/09/05 Role of glycans in cancer: functional and biomarker applications Seminar at the Max Planck Institute of Colloids and Interfaces, Berlin,
Max Planck Institute of Colloids and Interfaces, Berlin, (Berlim, Germany)
2016/06/19 Glycosyltransferases in Cancer GlycoT 2016
(Toronto, Canada)
2015/12/08 Glycosylation in Gastric Cancer: molecular mechanisms and clinical applications Seminar at the Weill Medical College of Cornell University
Weill Medical College of Cornell University (Nova Iorque, United States)
2015/09/15 Role of glycans in gastric cancer 23rd International Symposium on Glycoconjugates
International Glycoconjugate Organization (Split, Croatia)
2015/07/18 Glycoproteomic strategies targeting Sialyl­Tn in gastric cancer 13th International Workshop on Carcinoma­associated Mucins
Cambridge (Cambridge, United Kingdom)
2015/04/20 Glycan Biosynthesis and Processing The 11th Jenner Glycobiology and Medicine Symposium.
CNRS (Paris, France)
2014/11/13 Glycosylation in gastric cancer development and progression Seminar at RIKEN Japanese Institute
RIKEN (Tokyo, Japan)
2011/07/28 Glycans mediating Helicobacter pylori adhesion to gastric epithelial cells The Natcher Conference Center
NIH (Maryland , United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2015 - 2019 Impact of glycosylation in gastric cancer cell biology and intercellular communication
Supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2018 Novel insights in IBD pathogenesis: T-Cell receptor N-glycosylation as a new molecular mechanism.
Co-supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 - 2017 Lipid-based nanostrategies to fight Helicobacter pylori gastric infection
Co-supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2015/12 Decoding E-cadherin glycans functions in cancer: from functional glycomics to clinical applications
Co-supervisor
 Ciências Veterinárias (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 - 2015 A glycoproteomics discovery strategy for gastric cancer biomarkers
Supervisor
 Biomedicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2013/12/13 Discovery of Novel Biomarkers in Gastric Cancer Based on Post-Translational Modifications of Glycoproteins
Supervisor
 Biomedicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2012/11 - 2013/03/06 Characterization of gastric cancer glycosylation profile for the discovery of biomarkers
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 - 2012 Biological effects of Pteridium aquilinum and its toxin in gastric carcinogenesis: relationship with Helicobacter pylori infection
Supervisor
 Biomedicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal

Université Paris-Sud 11 Sciences et Techniques des Activités Physiques et Sportives, France
2007 - 2011 Characterization of molecular mechanisms relevant for Helicobacter pylori adhesion mediated by glycoconjugates expressed in gastric mucosa.
Supervisor
 Biomedicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2009/01/16 Characterization and role of O-glycosylation in gastric carcinogenesis and gastric carcinoma progression
Supervisor of Nuno Daniel Teixeira Marcos
 Biologia Humana (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2005 - 2009 Molecular characterization of E-cadherin glycosylation in cancer
Co-supervisor of Salomé Soares de Pinho
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Distinctions

Other distinction

2020 Member of the Direction of i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2017 International Glycoconjugate Organization - Secretary General 2017-2021
International Glycoconjugate Organization, Germany
2016 Member of the scientific board of the 12th Jenner Glycobiology and Medicine Symposium
2014 Member of the Scientific Advisory Board of the 23rd INTERNATIONAL SYMPOSIUM ON GLYCOCONJUGATES
2014 Member of the Organizing commitee of the 11th jenner glycobiology and medicine symposium
2013 Chair and Organizer of the International Meeting GLYCO-T 2014 In Porto, Portugal
2013 Member of the Scientific Council of the Portuguese Foundation for Science Conselho Científico para as Ciências da Vida e da Saúde da Fundação para a Ciência e a Tecnologia
Fundação para a Ciência e a Tecnologia, Portugal
2011 National Representant for the International Glycoconjugate Organization (IGO)
2010 Member of the Euroglycoscience forum
2004 Member of the Consortium for Functional Glycomics