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Ana Sofia Branco dos Santos was born in 1994 in Almada, Portugal. She obtained her B.Sc. in Applied Chemistry at Faculdade de Ciências e Tecnologia – Universidade Nova de Lisboa in 2015 and her MSc. in Bioorganic Chemistry from de same institution in 2017. In 2018 she was awarded with the Best Master Thesis in Organic Chemistry award from Portuguese Chemical Society. She is currently a student in the PhD programme in Sustainable Chemistry. Regarding publications, she has now published 5 papers in specialized journals. Her research focuses on Sustainable synthesis of heterocyclic compounds, involving metal-catalyzed reactions and N-containing compounds under the guidance of Professor M. Manuel B. Marques and Professor Artur M. S. Silva.
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Identification

Personal identification

Full name
Ana Sofia Santos

Citation names

  • Santos, A. Sofia

Author identifiers

Ciência ID
971C-3808-4DC9
ORCID iD
0000-0002-8852-0742

Email addresses

  • asb.santos@campus.fct.unl.pt (Professional)
  • ana.sofia20.8@gmail.com (Personal)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences - Inorganic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Upper intermediate (B2)
Portuguese (Mother tongue)
Education
Degree Classification
2018 - 2022
Ongoing
 Química Sustentável (Doutoramento)
Universidade de Aveiro, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017
Concluded
 Química Bioorgânica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Affiliation

Science

Category
Host institution 		Employer
2017 - Current Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Outputs

Publications

Book chapter
  1. "Metal-Catalyzed Synthesis of N-Heterocycles via Borrowing-Hydrogen Annulation". In More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, Volume I, 281-305. 2022.
    Published
  2. Santos, A. Sofia. "Recent Developments in the Chemical Synthesis of Amaryllidaceae Alkaloids". In Synthetic Approaches to Nonaromatic Nitrogen Heterocycles. 2020.
    Published
Conference poster
  1. Santos, Ana; M. Margarida Martins; Marques, M. Manuel B.. "Expanding azaindole synthesis via metal-catalysed reaction". Paper presented in International Symposium on Synthesis and Catalysis 2019 (ISySyCat2019), 2019.
  2. Santos, Ana; Marques, M. Manuel B.; Mortinho, Ana. "Sustainable synthesis of heterocyclic compounds on a soluble polymer support". Paper presented in 6th Portuguese Young Chemists Meeting, 2018.
Journal article
  1. Marques, Maria M B; Ferro, Rita; Viduedo, Nuno; Santos, Ana Sofia; Royo, Beatriz; Silva, Artur M. S.. "Bimetallic catalyzed synthesis of 2-arylindoles". Synthesis (2023): http://dx.doi.org/10.1055/a-2035-6420.
    10.1055/a-2035-6420
  2. Santos, A. Sofia; Ferro, Rita D.; Viduedo, Nuno; Maia, Luísa B.; Silva, Artur M. S.; Marques, M. Manuel B.. "Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert- Butoxide". ChemistryOpen 12 1 (2023): http://dx.doi.org/10.1002/open.202200265.
    10.1002/open.202200265
  3. Losada-Garcia, Noelia; Santos, A. Sofia; Marques, M. Manuel B.; Palomo, Jose M.. Corresponding author: Palomo, Jose M.. "Temperature-induced formation of Pd nanoparticles in heterogeneous nanobiohybrids: application in C-H activation catalysis". Nanoscale Advances (2023): http://dx.doi.org/10.1039/d2na00742h.
    10.1039/d2na00742h
  4. Marques, Maria M B; Royo, Beatriz; Raydan, Daniel; Friães, Sofia; Viduedo, Nuno; Santos, Ana Sofia; Gomes, Clara. "Manganese-catalyzed Synthesis of Imines from Primary Alcohols and Aromatic Amines". Synlett (2022): http://dx.doi.org/10.1055/a-1828-1678.
    10.1055/a-1828-1678
  5. "Retrossíntese: Uma Ferramenta Fundamental para a Construção de Novos Caminhos Sintéticos". QUÍMICA - Boletim da Sociedade Portuguesa de Química (2022): https://b-quimica.spq.pt/files/files/BSPQ/51.pdf.
    Accepted
  6. Santos, A. Sofia; Raydan, Daniel; Cunha, José C.; Viduedo, Nuno; Silva, Artur M. S.; Marques, M. Manuel B.. "Advances in Green Catalysis for the Synthesis of Medicinally Relevant N-Heterocycles". Catalysts 11 9 (2021): 1108. http://dx.doi.org/10.3390/catal11091108.
    10.3390/catal11091108
  7. Rodriguez-Oliva, Ivan; Losada-Garcia, Noelia; Santos, A. Sofia; Marques, M. Manuel B.; Palomo, Jose M.. "Palladium Nanocatalysts for Cascade C-N Cross-Coupling/Heck Reaction". Asian Journal of Organic Chemistry 10 4 (2021): 872-878. http://dx.doi.org/10.1002/ajoc.202100077.
    10.1002/ajoc.202100077
  8. Marques, M. Manuel B.; Santos, A. Sofia. "Pd-Catalyzed Functionalization of Aryl Amines on a Soluble Polymer Support". Synlett (2020): http://dx.doi.org/10.1055/s-0040-1707261.
    10.1055/s-0040-1707261
  9. Santos, A. Sofia; Martins, M. Margarida; Mortinho, Ana C.; Silva, Artur M.S.; Marques, M. Manuel B.. "Exploring the reactivity of halogen-free aminopyridines in one-pot palladium-catalyzed C–N cross-coupling/C–H functionalization". Tetrahedron Letters 61 37 (2020): 152303. http://dx.doi.org/10.1016/j.tetlet.2020.152303.
    10.1016/j.tetlet.2020.152303
  10. Santos, A. Sofia; Silva, Artur M. S.; Marques, M. Manuel B.. "Sustainable Amidation Reactions - Recent Advances". European Journal of Organic Chemistry (2020): http://dx.doi.org/10.1002/ejoc.202000106.
    10.1002/ejoc.202000106
  11. Santos, A. Sofia. "Investigação de aminopiridinas não-halogenadas como substratos promissores para a síntese de azaindoles". Química 44 158 (2020): 206.
    Published
  12. Santos, Ana. "Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization". Molecules (2018): http://www.mdpi.com/1420-3049/23/10/2673.
    10.3390/molecules23102673
  13. Santos, A. Sofia. "Síntese sustentável de compostos heterocíclicos. Azaindole – um núcleo privilegiado em química medicinal". Boletim da Sociedade Portuguesa de Química 42 149 (2018): 27-31.
    Published
  14. Santos, Ana. "The Role of PEG on Pd- and Cu-Catalyzed Cross-Coupling Reactions". Synthesis 49 (2017):
    10.1055/s-0036-1589498
  15. Santos, Ana. "One-Pot Synthesis of 1,2-Disubstituted 4-, 5-, 6-, and 7-Azaindoles from Amino-o-halopyridines via N-Arylation/Sonogashira/Cyclization Reaction". Organic Letters 19 19 (2017): 5118-5121. https://doi.org/10.1021/acs.orglett.7b02403.
    10.1021/acs.orglett.7b02403
  16. Santos, Ana. "Investigation of cationic Claisen-type electrophilic rearrangements of amides". Tetrahedron 71 35 (2015): 5994-6005. http://www.sciencedirect.com/science/article/pii/S0040402015008960.
    https://doi.org/10.1016/j.tet.2015.06.027
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/05/21 Exploring the reactivity of halogen-free aminopyridines for direct access to azaindole scaffolds Portuguese Young Chemists Meeting
2020/01/15 Exploring halogen-free aminopyridines as suitable scaffolds for direct access to azaindoles 13th National Organic Chemistry Meeting (13ENQO) and the 6th National Medicinal Chemistry Meeting (6ENQT)
Divisions of Organic Chemistry and Medicinal Chemistry of the Portuguese Chemical Society (SPQ) (Aveiro)

Scientific expedition

Activity description Institution / Organization
2022/01/29 - 2022/04/29 Synthesis and application of palladium nanocatalysts to attain azaindoles and other N-heterocycles Instituto de Catálisis y Petroleoquímica, Spain
Distinctions

Award

2021 Vencedor da 1ª Competição Nacional de Retrossíntese 2020.
Sociedade Portuguesa de Química, Portugal
2020 Best Oral Communication in Organic Chemistry
Universidade de Aveiro, Portugal

Sociedade Portuguesa de Química, Portugal
2018 Best Master Thesis in Organic Chemistry
Sociedade Portuguesa de Química, Portugal

Bluepharma, Portugal