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Diana Santos graduated in Anatomical Pathology, Cytology and Thanatology (ESTeSL - IPLisboa - 2016), has a Post-Graduation degree in Gynaecologic Cytology (ESS - IPPorto - 2017) and a Technologic Specialization in Quality, Environment and Safety Management (Citeforma - 2017). She is a Superior Technician at the Faculdade de Medicina da Universidade de Lisboa. Working at the Clinical Immunology Laboratory since 2018, she has the roles of Histopathology/Flow Cytometry Technician and Lab Manager. Her main work is in the laboratory diagnosis of human primary immunodeficiencies, for specialized clinical follow-up and research in this field.
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Identification

Personal identification

Full name
Diana Isabel Feliciano dos Santos

Citation names

  • Santos, Diana F
  • Diana F Santos

Author identifiers

Ciência ID
9613-65B9-3F77
ORCID iD
0000-0001-6914-8634

Email addresses

  • diana.santos@medicina.ulisboa.pt (Professional)
  • diana.f.santos@gimm.pt (Professional)
  • diana.if.santos@gmail.com (Personal)

Telephones

Telephone
  • 217999525 Ext.: 47371 (Professional)

Addresses

  • Gulbenkian Institute for Molecular Medicine, Faculdade de Medicina da Universidade de Lisboa. Av. Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Upper intermediate (B2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2016/12/02 - 2017/11/08
Concluded
 Curso de Técnico Especialista em Gestão da Qualidade, Ambiente e Segurança (Curso de Especialização Tecnológica)
Citeforma - Centro de Formação Profissional dos Trabalhadores de Escritório, Comércio, Serviços e Novas Tecnologias, Portugal
 18
2017/03/10 - 2017/07/01
Concluded
 Pós-Graduação em Citologia Ginecológica (Pós-Graduação)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
 17
2012/09 - 2016/10
Concluded
 Anatomia Patológica, Citológica e Tanatológica (Licenciatura)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
 17
Affiliation

Other Careers

Category
Host institution 		Employer
2018/09/03 - Current Técnico Superior (Técnico Superior) Universidade de Lisboa Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2017/07/17 - 2017/11/08 Estágio Curricular - Gestão da Qualidade Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2016/06/27 - 2016/07/15 Estágio Curricular - Tanatologia e Fetopatologia Hospital de Santa Maria, Portugal
2016/05/23 - 2016/06/16 Estágio Curricular - Imunocitoquímica Hospital de São José, Portugal
2016/04/18 - 2016/05/20 Estágio Curricular - Histopatologia Centro Hospitalar de Setubal EPE, Portugal
2016/03/07 - 2016/04/15 Estágio Curricular - Citopatologia Ginecológica Centro Hospitalar Barreiro Montijo EPE, Portugal
2016/01/04 - 2016/01/22 Estágio Curricular - Imunocitoquímica Hospital SAMS, Portugal
2015/11/30 - 2015/12/18 Estágio Curricular - Citopatologia Não Ginecológica Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2015/10/26 - 2015/11/27 Estágio Curricular - Histopatologia Hospital Curry Cabral, Portugal
2015/09/21 - 2015/10/19 Estágio Curricular - Citopatologia Ginecológica Hospital da Luz Lisboa, Portugal
2015/02/18 - 2015/06/09 Estágio Curricular - Histopatologia Centro Hospitalar Barreiro Montijo EPE, Portugal
Projects

Contract

Designation Funders
2021/03/29 - 2024/09/28 Imunodeficiências humanas: papel reparador das células T CD4 naïve
PTDC/MED-IMU/0938/2020
10.54499/PTDC/MED-IMU/0938/2020
Researcher
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 RNAscope dos tecidos linfóides de indivíduos infectados pelo HIV-2 ou pelo HIV-1
Programa Gilead Génese 2021
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Gilead Sciences Lda
Ongoing
2018/06/01 - 2021/05/31 Células T foliculares no cerne da infecção HIV
PTDC/MED-IMU/30474/2017
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Santos AB; Diana F Santos. "Combining RNAscope™ with Protein Detection: A Multi-Omics approach to archived FFPE blocks". Paper presented in II Congresso da BioMedLab (Associação Portuguesa de Ciências Biomédicas Laboratoriais), Coimbra, 2024.
  2. Santos AB; Diana F Santos. "RNAscopeTM: Tales of Old and New". Paper presented in XXIII Congresso Técnico de Anatomia Patológica, Santa Maria da Feira, 2023.
  3. Trombetta AC; B. Farias, Guilherme; Godinho-Santos, Ana; Gomes, AMC; Rosmaninho, Pedro; Conceição CM; Joel Laia; et al. "SARS-CoV-2 plasma viral load polarizes the systemic myeloid cell compartment towards an immunosuppressive/regulatory phenotype in severe COVID-19 patients". Paper presented in Virtual IMMUNOLOGY 2021, 2021.
  4. Trombetta AC, Farias GB, Gomes AMC, Godinho-Santos A, Rosmaninho P, Conceição CM, Henriques JJL, Santos DF, et al. "Timely acquisition of myeloid cell immune-regulatory phenotype and COVID-19 outcome". Paper presented in Conference on Retroviruses and Opportunistic Infections (CROI) 2021, 2021.
  5. Gomes, AMC; Joel Laia; Guilherme Farias; Ana Godinho-Santos; Diana F Santos; Rosmaninho, Pedro; Carolina M. Conceição; et al. "Role of Innate Lymphoid Cells in COVID-19". Paper presented in Conference on Retroviruses and Opportunistic Infections 2021, 2021.
Conference poster
  1. Santos, Diana F; Paulo-Pedro, Margarida; Moleirinho, Beatriz; Gomes, Andre Miguel Carapinha; Afonso RM Almeida; M Louise Markert; José G Marques; Susana Lopes-da-Silva. "Thymus Transplantation in FOXN1 Deficiency: 17 years Follow-up revealed Lack of Naïve T-Cell Sustainability despite Clinical Success". Paper presented in 13th ESLHO Symposium, 2024.
  2. Santos, Diana F; Paulo-Pedro, Margarida; Moleirinho, Beatriz; Gomes, Andre Miguel Carapinha; Afonso RM Almeida; M Louise Markert; José G Marques; Susana Lopes-da-Silva. "Thymus Transplantation in FOXN1 Deficiency: 17 years Follow-up revealed Lack of Naïve T-Cell Sustainability despite Clinical Success". Paper presented in ESID 21st Biennial Meeting, 2024.
  3. Paulo-Pedro, Margarida; Moleirinho, Beatriz; Diana F Santos; Gomes, Andre Miguel Carapinha; Susana Lopes-da-Silva; Raposo, AASF; Afonso RM Almeida; Ana Espada de Sousa. "The T-cell compartment at a single-cell level 17 years post thymus transplantation in a patient with FOXN1 mutation". Paper presented in SPI’49 XLIX Annual Meeting Portuguese Society for Immunology, 2024.
  4. Moleirinho, Beatriz; Paulo-Pedro, Margarida; Diana F Santos; Gomes, Andre Miguel Carapinha; Susana Lopes-da-Silva; Afonso RM Almeida; Ana E Sousa. "Living without a Thymus: Impact on CD4 T cell compartment". Paper presented in 3rd Symposium of the National Research Infrastructure for Genome Sequencing and Analysis, 2023.
  5. Paulo-Pedro, Margarida; Moleirinho, Beatriz; Santos, Diana F; Gomes, Andre Miguel Carapinha; Susana Lopes-da-Silva; Afonso RM Almeida; Ana E Sousa. "Once upon Athymia: the T-cell pool a patient with FOXN1 mutation, 17 years post-thymic transplant". Paper presented in 3rd Symposium of the National Research Infrastructure for Genome Sequencing and Analysis, 2023.
  6. Diana F Santos; Santos AB; Abecasis AB; Sousa AE. "Quantification of viral mRNA in lymph nodes from HIV- 2 or HIV-1 infected individuals using RNAscope in situ hybridization". Paper presented in XLVII Annual Meeting SPI, 2022.
  7. Junginger ZI, Adameck R, Rosmaninho P, Santos DF, Marques M, Raposo ASF, Sousa AE, Almeida ARM. "A cell-intrinsic role for RANK in human thymic regulatory T cells". Paper presented in XLVII Annual Meeting SPI, 2022.
  8. Farias GB, Marques RT, Gomes AMC, Santos DF, Junginger ZI, Sousa AE, Badura R.. "SAMHD1 segregates monocyte and dendritic cells populations: Hints from HIV-1 and HIV-2 infections". Paper presented in XLVII Annual Meeting SPI, 2022.
  9. Marques RT, Farias GB, Santos DF, Gomes AMC, Junginger ZI, Sousa AE, Badura R.. "Circulating Lymphocytes in HIV-1 and HIV-2 infections: a comprehensive spectral flow approach to address chronic immune infection". Paper presented in XLVII Annual Meeting SPI, 2022.
  10. Adriana Motta Raymundo; Susana Lopes-da-Silva; Rosmaninho, Pedro; Santos, Diana F; P. Silva, Sara; Esteves I; Bandeira M; et al. "A20 haploinsufficiency and immunodeficiency - diverse phenotype across 3 generations.". Paper presented in 25th Annual Meeting of the Portuguese Society of Human Genetics, 2021.
  11. Varandas C; Caldas C; Santos AR; P. Silva, Sara; Santos, Diana F; Fernandes L; Ferreira C; et al. "Da clínica ao gene - do gene à terapêutica". Paper presented in XLII Reunião anual da Sociedade Portuguesa de Alergologia e Imunologia Clínica – SPAIC, 2021.
  12. Adriana Motta Raymundo; Rosmaninho, Pedro; Santos, Diana F; P. Silva, Sara; Ana Espada de Sousa; Susana Lopes-da-Silva. "Genetic Evaluation of Complex Primary Immunodeficiency". Paper presented in GenomePT Symposium, 2021.
  13. Motta A; Rosmaninho P; Diana F Santos; Ferreira RD; Silva SP; Ferreira C; Sousa AE; Silva SL. "Contribution of Helicobacter pylori infection to the clinical and immunological profile of Common Variable Immunodeficiency (CVID) and relationship with the underlying genetic landscape.". Paper presented in XLVI Annual Meeting of the Portuguese Society for Immunology, 2021.
  14. Trombetta AC; B. Farias, Guilherme; Gomes, AMC; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição CM; Joel Laia; et al. "Severe COVID-19 recovery is associated with timely acquisition of a myeloid cell immune-regulatory phenotype.". Paper presented in XLVI Annual Meeting of the Portuguese Society for Immunology, 2021.
  15. Gomes, AMC; B. Farias, Guilherme; Dias-Silva, Manuel; Joel Laia; Trombetta AC; Godinho-Santos, Ana; Rosmaninho, Pedro; et al. "SARS-CoV-2 pneumonia recovery is linked to an expansion of type 2 innate lymphoid cells expressing CCR10.". Paper presented in XLVI Annual Meeting of the Portuguese Society for Immunology, 2021.
  16. B. Farias, Guilherme; Gomes, AMC; Godinho-Santos, Ana; Rosmaninho, Pedro; Santos, Diana F; Conceição CM; Joel Laia; et al. "Distinct profile of the systemic myeloid cell response in HIV-1 and SARS-CoV-2 acute infections.". Paper presented in XLVI Annual Meeting of the Portuguese Society for Immunology, 2021.
  17. Raymundo A, Rosmaninho P, Santos DF, Ferreira RD, Silva SP, Ferreira C, Sousa AE, Silva SL.. "Modulation of the common variable immunodeficiency (CVID) clinical and immunological profile by Helicobacter pylori infection and the underlying genetic landscape". Paper presented in 19th Biennial Meeting of the European Society for Immunodeficiencies, 2020.
  18. Fernandes M, Silva SP, Potes AF, Santos DF, Pais M, Ferrão A, Sousa AE, Silva SL. "Citopenias, Doença linfocítica-granulomatosa pulmonar e infeção – Um caso representativo da complexidade na IDCV". Paper presented in A interface imuno-hematológica – IX Reunião do Grupo Português de Imunodeficiências Primárias, 2019.
  19. Curado AD, Viegas IF, Santos DF, Potes AF, Palaré MJ, Salgado C, Esteves I, Ferrão A. "Quando a Síndrome de Evans finalmente se revela". Paper presented in A interface imuno-hematológica – IX Reunião do Grupo Português de Imunodeficiências Primárias, 2019.
Journal article
  1. Paulo-Pedro, Margarida; Moleirinho, Beatriz; Santos, Diana F; Gomes, Andre Miguel Carapinha; Rei, Margarida; Almeida, Afonso; Marques, José G.; Susana Lopes-da-Silva; Ana E Sousa. Corresponding author: Ana E Sousa. "Adulthood outcomes of thymic transplantation in a case of congenital athymia due to FOXN1 mutation". Journal of Allergy and Clinical Immunology (2025): https://doi.org/10.1016/j.jaci.2025.02.006.
    Accepted • 10.1016/j.jaci.2025.02.006
  2. Motta-Raymundo, Adriana; Rosmaninho, Pedro; Santos, Diana F.; Ferreira, Ruben D.; Silva, Sara P.; Ferreira, Cristina; Sousa, Ana E.; Silva, Susana L.. "Contribution of Helicobacter pylori to the Inflammatory Complications of Common Variable Immunodeficiency". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.834137.
    10.3389/fimmu.2022.834137
  3. Gomes, André M. C.; Farias, Guilherme B.; Dias-Silva, Manuel; Laia, Joel; Trombetta, Amelia C.; Godinho-Santos, Ana; Rosmaninho, Pedro; et al. "SARS-CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10". European Journal of Immunology 51 12 (2021): 3194-3201. http://dx.doi.org/10.1002/eji.202149311.
    Published • 10.1002/eji.202149311
  4. Farias, Guilherme B.; Badura, Robert; Conceição, Carolina M.; Gomes, André M. C.; Godinho-Santos, Ana; Laia, Joel; Rosmaninho, Pedro; et al. "Acute HIV-1 and SARS-CoV-2 Infections Share Slan+ Monocyte Depletion - Evidence from an Hyperacute HIV-1 Case Report". Viruses 13 9 (2021): 1805. http://dx.doi.org/10.3390/v13091805.
    Published • 10.3390/v13091805
  5. Trombetta, Amelia C.; Farias, Guilherme B.; Gomes, André M. C.; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição, Carolina M.; Laia, Joel; et al. "Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.691725.
    Published • 10.3389/fimmu.2021.691725
Distinctions

Award

2017 Prémio Caixa Geral de Depósitos 2017
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Caixa Geral de Depositos, Portugal