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Identification

Personal identification

Full name
Hélia Cristina de Oliveira Neves

Citation names

  • Neves, Hélia

Author identifiers

Ciência ID
9610-7446-BCF7
ORCID iD
0000-0002-6700-4976

Email addresses

  • helia.neves@campus.ul.pt (Professional)
  • hneves@medicina.ulisboa.pt (Professional)

Telephones

Telephone
  • 217999528 Ext.: 47364 (Professional)

Addresses

  • Instituto de Histologia e Biologia do Desenvolvimento. Faculdade de Medicina da Universidade de Lisboa /IMM, Edifício Egas Moniz, Piso 3, Ala C, Av. Professor Egas Moniz, 1649-028 , Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Developmental Biology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Education
Degree Classification
2019/09/01 - 2020/09/30
Concluded
 Motion Design (Outros)
Lisbon School of Design, Portugal
 16/20
2006
Concluded
 Biomedicina (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"The effect of Notch ligands, Delta1 and Jagged1 in human hematopoiesis" (THESIS/DISSERTATION)
 20/20
2004
Concluded
 Provas de aptidão Pedagógica e Capacidade Científica (Especialização pós-licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
 Aprovação com Muito Bom por unanimidade.
1995
Concluded
 Biology; domain:- Scientific (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
 16/20
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2006/02/01 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2024/10/01 - Current Senior Reseacher at E. Gomes Lab - GIMM Faculdade de Medicina da Universidade de Lisboa, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2016/01/01 - 2019/12/31 Senior Researcher at Instituto Histologia e Biologia do Desenvolvimento - FMUL Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
Outputs

Publications

Book chapter
  1. Zilhão, Rita; Neves, Hélia. "Tumor Niche Disruption and Metastasis: The Role of Epithelial-Mesenchymal Transition (EMT)". In Molecular and Cell Biology of Cancer. When Cells Break the Rules and Hijack Their Own Planet, edited by Springer, Learning Materials in Biosciences, Switzerland. Springer, Learning Materials in Biosciences, Switzerland, 2019.
    Published
  2. Neves, Hélia; Zilhão, Rita. "Development of parathyroid glands and C-cells". In Parathyroid glands. Regulation, role in human disease and indications for surgery, edited by Maya Ashord editor Nova Biomedical NY Nova Science Publishers Inc. Maya Ashord editor Nova Biomedical NY Nova Science Publishers Inc, 2014.
Journal article
  1. Alcobia, Isabel; Gama-Carvalho, Margarida; Magalhães, Leonor; Proa, Vitor; Ferreira, Sara; Henrique, Domingos; Neves, Hélia. "Thymus-forming potential of the second pharyngeal pouch and its regulation by local mesenchyme in avian embryos". Cell Reports 43 12 (2024): 114998. https://doi.org/10.1016/j.celrep.2024.114998.
    10.1016/j.celrep.2024.114998
  2. Figueiredo, Marta; Zilhão, Rita; Neves, Hélia. "Thymus Inception: Molecular Network in the Early Stages of Thymus Organogenesis". International Journal of Molecular Sciences 21 16 (2020): 5765. http://dx.doi.org/10.3390/ijms21165765.
    Open access • Published • 10.3390/ijms21165765
  3. Figueiredo, M.; Neves, H.. "Isolation of Embryonic Tissues and Formation of Quail-Chicken Chimeric Organs Using The Thymus Example.". JOVE-JOURNAL OF VISUALIZED EXPERIMENTS 144 (2019):
    Published • 10.3791/58965
  4. Figueiredo, Marta; Neves, Helia. "Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm". Jove-Journal of Visualized Experiments 136 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000444752100030&KeyUID=WOS:000444752100030.
    10.3791/57114
  5. Figueiredo, Marta; Silva, Joana Clara; Santos, Ana Sofia; Proa, Vitor; Alcobia, Isabel; Zilhao, Rita; Cidadao, Antonio; Neves, Helia. "Notch and Hedgehog in the thymus/parathyroid common primordium: Crosstalk in organ formation". Developmental Biology 418 2 (2016): 268-282. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000384872900005&KeyUID=WOS:000384872900005.
    10.1016/j.ydbio.2016.08.012
  6. Laranjeiro, Ricardo; Alcobia, Isabel; Neves, Helia; Gomes, Andreia C.; Saavedra, Pedro; Carvalho, Catarina C.; Duarte, Antonio; Cidadao, Antonio; Parreira, Leonor. "The Notch Ligand Delta-Like 4 Regulates Multiple Stages of Early Hemato-Vascular Development". Plos One 7 4 (2012): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000305341600042&KeyUID=WOS:000305341600042.
    10.1371/journal.pone.0034553
  7. Neves, Helia; Dupin, Elisabeth; Parreira, Leonor; Le Douarin, Nicole M.. "Modulation of Bmp4 signalling in the epithelial-mesenchymal interactions that take place in early thymus and parathyroid development in avian embryos". Developmental Biology 361 2 (2012): 208-219. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000299499200002&KeyUID=WOS:000299499200002.
    10.1016/j.ydbio.2011.10.022
  8. Santos, Margarida Almeida; Sarmento, Leonor Morais; Rebelo, Manuel; Doce, Ana Agua; Maillard, Ivan; Durnortier, Alexis; Neves, Helia; et al. "Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells". Proceedings of the National Academy of Sciences of the United States of America 104 39 (2007): 15454-15459. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000249806900051&KeyUID=WOS:000249806900051.
    10.1073/pnas.0702891104
  9. Neves, Helia; Weerkamp, Floor; Gomes, Andreia C.; Naber, Brigitta A. E.; Gameiro, Paula; Becker, Jorg D.; Lucio, Paulo; et al. "Effects of Delta1 and Jagged1 on early human hematopoiesis: Correlation with expression of notch signaling-related genes in CD34(+) cells". Stem Cells 24 5 (2006): 1328-1337. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240639200022&KeyUID=WOS:000240639200022.
    10.1634/stemcells.2005-0207
  10. Neves, H.; Weerkamp, F.; Naber, B.; Becker, J. D.; Lucio, P.; Clode, N.; van Dongen, J.; Staal, F.; Parreira, L.. "Differential effects of Notch ligands Delta1 and Jagged1 in human myelopoiesis". Experimental Hematology 32 7 (2004): 95-95. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000222914700242&KeyUID=WOS:000222914700242.
  11. Neves, H.; Weerkamp, F.; Naber, B. A. E.; Gameiro, P.; Becker, J. D.; Lucio, P.; Clode, N.; et al. "Differential effects of Delta1 and jagged1 in early human myelopoiesis: Correlation with distinct gene-expression profiles in CD34+ cells". Blood 104 11 (2004): 762A-763A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000225127502787&KeyUID=WOS:000225127502787.
  12. Alcobia, I.; Quina, A. S.; Neves, H.; Clode, N.; Parreira, L.. "The spatial organization of centromeric heterochromatin during normal human lymphopoiesis: Evidence for ontogenically determined spatial patterns". Blood 102 11 (2003): 148B-148B. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186537100591&KeyUID=WOS:000186537100591.
    10.1016/s0014-4827(03)00335-5
  13. Neves, H.; Lucio, P.; Clode, N.; Parreira, A.; Parreira, L.. "Notch ligands Delta1 and Jagged1 in early human myelopoiesis". Blood 102 11 (2003): 147B-147B. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186537100586&KeyUID=WOS:000186537100586.
  14. Parreira, L.; Neves, H.; Simoes, S.. "Notch and lymphopoiesis: a view from the microenvironment". Seminars in Immunology 15 2 (2003): 81-89. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000182504200003&KeyUID=WOS:000182504200003.
    10.1016/s1044-5323(03)00004-6
  15. Neves, H.; Lucio, P.; Alcobia, I.; Clode, N.; Parreira, L.. "Differential role of Notch ligands Delta-1 and Jagged-1 in human hematopoietic progenitor cell differentiation". Blood 100 11 (2002): 717A-717A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000179184702827&KeyUID=WOS:000179184702827.
  16. Alcobia, I.; Quina, A. S.; Neves, H.; Clode, N.; Parreira, L.. "The spatial organization of heterochromatic compartments in human peripheral blood cells is established during hematopoietic differentiation". Blood 100 11 (2002): 150B-150B. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000179184800628&KeyUID=WOS:000179184800628.
  17. Jaleco, A. C.; Neves, H.; Hooijberg, E.; Gameiro, P.; Clode, N.; Haury, M.; Henrique, D.; Parreira, L.. "Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation". Journal of Experimental Medicine 194 7 (2001): 991-1001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000171671900012&KeyUID=WOS:000171671900012.
    10.1084/jem.194.7.991
  18. Neves, H.; Ramos, C.; da Silva, M. G.; Parreira, A.; Parreira, L.. "The nuclear topography of ABL, BCR, PML, and RAR alpha genes: Evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation". Blood 93 4 (1999): 1197-1207. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000078559200009&KeyUID=WOS:000078559200009.
  19. Neves, H.; da Silva, M. G.; Ramos, C.; Parreira, A.; Parreira, L.. "The spatial distribution of genes involved in human leukemic translocations". European Journal of Human Genetics 6 (1998): 178-178. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074522800803&KeyUID=WOS:000074522800803.
  20. Parreira, L.; Telhada, M.; Ramos, C.; Hernandez, R.; Neves, H.; CarmoFonseca, M.. "The spatial distribution of human immunoglobulin genes within the nucleus: evidence for gene topography independent of cell type and transcriptional activity". Human Genetics 100 5-6 (1997): 588-594. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997XY68100019&KeyUID=WOS:A1997XY68100019.
    10.1007/s004390050558
  21. Neves, H.; daSilva, M. G.; Ramos, C.; Parreira, A.; Parreira, L.. "The spatial distribution of PML and RAR-alpha genes within the nucleus of early human hemopoietic precursors". Experimental Hematology 24 9 (1996): 70-70. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1996VC09200070&KeyUID=WOS:A1996VC09200070.
Preprint
  1. Isabel Alcobia; Margarida Gama-Carvalho; Leonor Magalhães; Vitor Proa; Domingos Henrique; Hélia Neves. "Thymus formation in uncharted embryonic territories". 2022. https://doi.org/10.1101/2022.03.09.483697.
    10.1101/2022.03.09.483697
Thesis / Dissertation
  1. Neves, Hélia. ""Efeito dos ligandos Notch, Delta1 e Jagged1 na hematopoiese humana."". PhD, 2006.
Distinctions

Award

2003 First prize of investigation
Pfizer Portugal, Portugal
1998 Second prize of investigation
Pfizer Portugal, Portugal

Other distinction

2007 Post-doctoral fellowship
Fondation pour la Recherche Médicale, France
2004 FLAD Short-term fellowship
Fundação Luso-Americana, Portugal
2003 EMBO Short-term fellowship
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
1999 EMBO Scholarship
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
1998 Doctoral fellowship, PRAXIS XXI/BD/13492/97.
Fundação para a Ciência e a Tecnologia, Portugal
1996 Initiation to Research fellowship, FMRH/BIC/1571/1996.
Fundação para a Ciência e a Tecnologia, Portugal