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Ana Carvalho obtained her degree in Biochemistry in 2018, in the Faculty of Sciences of University of Porto (FCUP) and Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS). For the final degree Project/Internship in Biochemistry, she studied the side effects of chemotherapy agents on the brain of differently aged mice at UCIBIO/REQUIMTE, Laboratory of Toxicology in the Faculty of Pharmacy of the University of Porto (FFUP). From September 2018 and forward, while continuing researching on the neurotoxic effects of chemotherapy on the mice, she enrolled in the Masters in Analytical, Clinical, and Forensic Toxicology in the Faculty of Pharmacy of University of Porto, finished in December 2020. Currently, she is in the last year of the PhD programme in Pharmaceutical Sciences in the field of toxicology in the Faculty of Pharmacy in the University of Porto.
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Identification

Personal identification

Full name
Ana Rita Constantino Dias Carvalho

Citation names

  • Dias-Carvalho, Ana
  • Carvalho, Ana

Author identifiers

Ciência ID
951C-4475-0919
ORCID iD
0000-0001-6099-0681

Email addresses

  • arcdc97@gmail.com (Professional)

Telephones

Telephone
  • 220428596 (Professional)

Addresses

  • Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, 4050-313, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Portuguese (Mother tongue)
Education
Degree Classification
2021/05/01 - 2025/04/05
Ongoing
 Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Unveiling the neurotoxic mechanisms of anticancer drugs: combining insights from neuronal and glial contributions to chemobrain" (THESIS/DISSERTATION)
2018/09/15 - 2020/12/30
Concluded
 Toxicologia Analítica Clínica e Forense (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"The neurotoxicity of doxorubicin and mitoxantrone: chemobrain studies using infant, adult, and old mice" (THESIS/DISSERTATION)
 18/20
2015/09/15 - 2018/07/25
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"The influence of doxorubicin and mitoxantrone on the redox status of the brain of differently aged mice" (THESIS/DISSERTATION)
 15/20
Projects

Grant

Designation Funders
2018/12 - 2019/11/01 Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs?
PTDC/DTP-FTO/1489/2014
Master Student Fellow
Fundação da Ciência e Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
PhD Student Fellow
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
PhD Student Fellow
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
PhD Student Fellow
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Costa, Vera Marisa; Dias Carvalho, Ana Rita; Capela, Joao Paulo; Carvalho, Felix. "Chemobrain". In Toxicological Risk Assessment and Multi-System Health Impacts from Exposure, 61-72. Elsevier, 2021.
    Published • 10.1016/b978-0-323-85215-9.00049-0
Conference abstract
  1. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos, Maria Lourdes; Sá, Susana Isabel; Capela, João Paulo; Costa, Vera Marisa. "Mitoxantrone impairs Bax and phosphorylated Tau expression on the brain of adult mice: an in vivo ‘chemobrain’ study on clinically relevant doses". Paper presented in 15th Young European Scientist (YES), Porto, 2021.
    Published • 10.1097/j.pbj.0000000000000100
  2. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Ferreira, Rita; Carvalho, Félix; et al. "The long-term neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Paper presented in 56th Congress of the European Societies of Toxicology (Eurotox 2021), 2021.
    Published • https://doi.org/10.1016/S0378-4274(21)00663-9
  3. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos, Maria Lourdes; Sá, Susana Isabel; Capela, João Paulo; Costa, Vera Marisa. "In vivo chemobrain study: The effects of doxorubicin and mitoxantrone in the brain of differently aged mice". Paper presented in 14th Young European Scientist (YES), Porto, 2019.
    Published • 10.1097/j.pbj.0000000000000054
  4. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Differential effects of doxorubicin and mitoxantrone in brain glutathione levels of different aged mice". Paper presented in 13th Young European Scientist (YES), Porto, 2018.
    Published • 10.1016/j.pbj.0000000000000032
Conference poster
  1. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Ferreira, Rita; Carvalho, Félix; et al. "A neurotoxicidade de longo prazo da doxorrubicina no cérebro de ratinhos CD-1 adultos". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  2. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Ferreira, Rita; Carvalho, Félix; et al. "The neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Paper presented in Ciência 2021 – Science and Technology in Portugal Summit, 2021.
  3. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Ferreira, Rita; Carvalho, Félix; et al. "The neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Paper presented in III Iberian Toxicology event: Toxiology Challanges, 2021.
  4. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Paper presented in 14º Encontro de Investigação Jovem da U. Porto (IJUP ’21), 2021.
  5. Dias-Carvalho, Ana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Capela, João Paulo; Sá, Susana Isabel; Costa, Vera Marisa. "Chemobrain: assessing the potential to recovery from doxorubicin-induced-neurotoxic effects in CD-1 mice". Paper presented in 14º Encontro de Investigação Jovem da U. Porto (IJUP ’21), 2021.
  6. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "Doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study.". Paper presented in XII Biochemistry Day, 2021.
  7. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Lourdes Bastos, Maria; Sá, Susana Isabel; Capela, João Paulo; Costa, Vera Marisa. "Chemobrain study: differential effects of doxorubicin and mitoxantrone in the brain of CD-1 mice". Paper presented in 1st International Electronic Conference on Brain Sciences, 2020.
  8. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Neurotoxicidade da mitoxantrona e doxorrubicina: estudo in vivo em diferentes idades.". Paper presented in 2º Encontro Nacional de Jovens Investigadores em Oncologia, 2020.
  9. Dias-Carvalho, Ana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Capela, João Paulo; Sá, Susana Isabel; Costa, Vera Marisa. "Doxorubicin Increases Apoptotic Markers in the hipocampal formation of CD-1 mice". Paper presented in VI jornadas da Bioquímica: “O passaporte para a inovação”, 2020.
  10. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Lourdes Bastos, Maria; Capela, João Paulo; Costa, Vera Marisa. "“In vivo chemobrain study: The effects of doxorubicin and mitoxantrone in the brain of differently aged mice”". Paper presented in 14th Young European Scientist (YES), 2019.
  11. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Doxorubicin and mitoxantrone effects on the brain of differently aged mice: an in vivo chemobrain study". Paper presented in 55th Congress of the European Societies of Toxicology (Eurotox 2019), 2019.
    10.1364/bio.2006.tuc10
  12. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Differential effects of doxorubicin and mitoxantrone in the brain redox status of differently aged mice". Paper presented in 10th Annual International (bio)Medical Students Meeting, 2019.
  13. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "The effects of doxorubicin and mitoxantrone in brain glutathione levels of differently aged mice". Paper presented in iMed Conference® 10.0, 2018.
Journal article
  1. Ana Dias-Carvalho; Mariana Ferreira; Ana Reis-Mendes; Rita Ferreira; Maria de Lourdes Bastos; Eduarda Fernandes; Susana Isabel Sá; et al. "Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice". Heliyon (2024): https://doi.org/10.1016/j.heliyon.2024.e31608.
    10.1016/j.heliyon.2024.e31608
  2. Ana Dias-Carvalho; Susana Isabel Sá; Félix Carvalho; Eduarda Fernandes; Vera Marisa Costa. "Inflammation as common link to progressive neurological diseases". Archives of Toxicology (2024): https://doi.org/10.1007/s00204-023-03628-8.
    10.1007/s00204-023-03628-8
  3. Dias-Carvalho, Ana; Mariana Ferreira; Reis-Mendes, Ana; Ferreira, Rita; Bastos, Maria Lourdes; Fernandes, Eduarda; Sá, Susana I; Sá SI; et al. "Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice". Archives of Toxicology (2022):
    Accepted
  4. Dias-Carvalho, Ana; Ferreira, Mariana; Ferreira, Rita; Bastos, Maria de Lourdes; Sá, Susana Isabel; Capela, João Paulo; Carvalho, Félix; Costa, Vera Marisa. "Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events". Archives of Toxicology 96 1 (2021): 11-78. http://dx.doi.org/10.1007/s00204-021-03171-4.
    10.1007/s00204-021-03171-4
  5. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Doxorubicin and mitoxantrone effects on the brain of differently aged mice: an in vivo chemobrain study". Toxicology Letters 314 (2019):
    Published • 10.1016/j.toxlet.2019.09.002
Online resource
  1. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos, Maria Lourdes; Sá, Susana I; Capela, João Paulo; Costa, Vera Marisa. Effects of Doxorubicin and Mitoxantrone in the brain of differently aged mice: in vivo chemobrain study. 2019. https://sciforum.net/paper/view/conference/6364.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/02/11 Mitoxantrone causes oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice LII Reunião da Sociedade Portuguesa de Farmacologia, XL Reunião de Farmacologia Clínica e XXI Reunião de Toxicologia.
Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (Porto, Portugal)
2021/05/07 The effects of doxorubicin and mitoxantrone in the brain of adult mice 14th Meeting of young researches of U. Porto (IJUP 2021)
University of Porto (Porto, Portugal)
2021/02/18 Chemobrain: evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice LI Reunião da Sociedade Portuguesa de Farmacologia, XLIX Reunião de Farmacologia Clínica e XX Reunião de Toxicologia.
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2020/09/07 Mitoxantrone impairs Bax and phosphorylated Tau expression on the brain of adult mice: an in vivo ‘chemobrain’ study on clinically relevant doses. 15th Young European Scientist (YES) Meeting
Faculty of Medicine of the University of Porto (Porto, Portugal)
2020/02 The effects of doxorubicin and mitoxantrone in mice brain at different aging stages: an in vivo chemobrain study XL Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XVIX Reunião de Toxicologia
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02 The effects of doxorubicin and mitoxantrone in the brain of different age mice: in vivo chemobrain study 13 th Meeting of young researches of U. Porto (IJUP' 20)
University of Porto (Porto, Portugal)
2019/03 A chemobrain study in differently aged CD-1 mice Animal Model of Disease: workshop de experimentação animal (2nd edition)
University of Aveiro (Aveiro)
2019/02 Doxorubicin and mitoxantrone effects on the brain´s redox status of differently aged mice 12th Meeting of young researches of U. Porto (IJUP ’19)
University of Porto (Porto, Portugal)
2019/02 Effects of doxorubicin and mitoxantrone in brain glutathione of different aged mice: an in vivo study XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica, XVIII Reunião de Toxicologia
Portuguese Society of Pharmacology (Porto, Portugal)
2018 Differential effects of doxorubicin and mitoxantrone in brain glutathione levels of different aged mice 14th Young European Scientist (YES), Meeting
Faculty of Medicine of the University of Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/09 - 2021/07 The Long-term Mechanisms of Chemobrain: Neurotoxicity of Doxorubicin in CD-1 Mice
Co-supervisor
 Bioquímica
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/02/06 - 2019/02/08 XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica, XVIII Reunião de Toxicologia (2019/02/06 - 2019/02/08)
Meeting (Member of the Organising Committee)

Journal scientific committee

Journal title (ISSN) Publisher
2019/03/10 - Current Brazilian Journal of Pharmaceutical Sciences (1984-8250) SciELO
Distinctions

Award

2021 Honorable mention for poster presentation in the XII Biochemistry Day of the University of Aveiro, Portugal
Universidade de Aveiro, Portugal
2020 Best Oral Communication health sciences category of the 13th Youth Research Meeting for students of Porto University (IJUP)
Universidade do Porto, Portugal
2020 Second best oral presentation in the 2ª Edição do Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto
Universidade do Porto Faculdade de Farmácia, Portugal