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Inês Vasconcelos Miranda Santos. Completed the Doutoramento in Biociências in 2017 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Mestrado in Mestrado em Biologia Celular in 2005 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and Licenciatura in Efeito cardiprotector da adenosina in 2002/09 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia. Is Research Assistant in Centro de Inovação em Biomedicina e Bioengenharia (CIBB). Published 4 articles in journals. Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry, Exact Sciences with emphasis on Computer and Information Sciences with emphasis on Bioinformatics and Exact Sciences with emphasis on Physical Sciences with emphasis on Chemical Physics. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Amyotrophic lateral sclerosis; Urine-derived stem cells; Neuronal differentiation; Mitochondrial function; Thiol redox; Mitochondrial dysfunction; Neurodegeneration; ALS; Reactive oxygen; nitrogen and sulfur species; Systems analysis; Kinetic modeling; Structure-activity relationships; Blood-Brain Barrier; Passive Diffusion; Amphiphilic Molecules; Model Membrane Systems; systems biology; analytical biochemistry; 13C-isotopomer analysis; LC-MS; GC-MS; NMR; HPLC; cell culture; bioreactor; flux balance analysis; metabolic flux analysis; multi variate data analysis; principal component analysis; partial least squares; multiple linear regression; objective function; least square optimization; experimental design; metadata; Physics and Chemistry; Mathematics; .
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Identification

Personal identification

Full name
Inês Vasconcelos Miranda Santos

Citation names

  • Miranda-Santos, Inês

Author identifiers

Ciência ID
951B-6F1D-F855
ORCID iD
0000-0002-5467-2756

Email addresses

  • inessantos@ci.uc.pt (Professional)
  • mirandasantos@cnc.uc.pt (Professional)
  • inesmirandasantos@gmail.com (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Exact Sciences - Physical Sciences - Chemical Physics

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
French Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2)
Spanish; Castilian Elementary (A2) Elementary (A2) Elementary (A2) Intermediate (B1)
Education
Degree Classification
2019/10/07
Concluded
 Biociências (Doutoramento)
Major in Especialidade: Bioquímica
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
"Analysis of metabolic heterogeneity over cell division cycle in non-synchronized yeast - a 13C based experimental-computational approach" (THESIS/DISSERTATION)
2005
Concluded
 Mestrado em Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Ciclo do Piruvato no Coração" (THESIS/DISSERTATION)
 Muito Bom
2002/09
Concluded
 Efeito cardiprotector da adenosina (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2019/11/08 - 2021/09/30 Research Assistant (Research) Centro de Inovação em Biomedicina e Bioengenharia (CIBB), Portugal
Centro de Inovação em Biomedicina e Bioengenharia (CIBB), Portugal
Projects

Contract

Designation Funders
2022/01/01 - 2023/06/30 Role of mitochondrial-thiol homeostasis in neurodegeneration: implication for amyotrophic lateral sclerosis
EXPL/BTM-TEC/1407/2021
Research Fellow
Universidade de Coimbra, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2008/01/01 - 2011/12/31 Reconstruction and systems analysis of the reaction networks of reactive oxygen, nitrogen and sulfur species in representative physiological systems
PTDC/QUI/70523/2006
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universitat de Lleida, Spain

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/09/30 Quantitative Modeling of Passive Trancytotic Diffusion of Amphiphilic Molecules Across the Blood-Brain Barrier
PTDC/SAU-FCF/69072/2006
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2006/02/05 - 2010/02/04 INTERMEDIARY METABOLISM IN THE DIABETIC HEART BY 13C NMR ISOTOPOMER ANALYSIS
SFRH/BD/18158/2004
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2022/01/15 - 2025/01/14 Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis
PTDC/BTM-ORG/0055/2021
Universidade de Coimbra, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. MirandaSantos, Inês. "Modelling the metabolic heterogeneity over the cell division cycle towards metabolic flux rate quantification - a (13)c-Metabolic Flux Analysis approach". Paper presented in European Journal of Clinical Investigation, 2019.
    Published
Journal article
  1. Sónia A. Pinho; Cláudio F. Costa; Cláudia M. Deus; Sonia L. C. Pinho; Inês Miranda-Santos; Gonçalo Afonso; Olivia Bagshaw; et al. "Mitochondrial and metabolic remodelling in human skin fibroblasts in response to glucose availability". The FEBS Journal (2022): https://doi.org/10.1111/febs.16413.
    10.1111/febs.16413
  2. Bauer, Raimund; Udonta, Florian; Wroblewski, Mark; Ben-Batalla, Isabel; Santos, Ines Miranda; Taverna, Federico; Kuhlencord, Meike; et al. "Blockade of myeloid-derived suppressor cell expansion with all-trans retinoic acid increases the efficacy of anti-angiogenic therapy". Cancer Research (2018): canres.3415.2017. http://dx.doi.org/10.1158/0008-5472.can-17-3415.
    Published • 10.1158/0008-5472.can-17-3415
  3. Rohlenova, Katerina; Veys, Koen; Miranda-Santos, Ines; De Bock, Katrien; Carmeliet, Peter. "Endothelial Cell Metabolism in Health and Disease". Trends in Cell Biology 28 3 (2018): 224-236. http://dx.doi.org/10.1016/j.tcb.2017.10.010.
    Published • 10.1016/j.tcb.2017.10.010
  4. Miranda-Santos, Ines; Gramacho, Silvia; Pineiro, Marta; Martinez-Gomez, Karla; Fritz, Michel; Hollemeyer, Klaus; Salvador, Armindo; Heinzle, Elmar. "Mass Isotopomer Analysis of Nucleosides Isolated from RNA and DNA Using GC/MS". Analytical Chemistry 87 1 (2014): 617-623. http://dx.doi.org/10.1021/ac503305w.
    Published • 10.1021/ac503305w

Other

Other output
  1. Mitochondrial and metabolic remodeling in human skin fibroblasts in response to glucose availability. 2021. Cláudio F. Costa; Sónia A. Pinho; Sonia L.C. Pinho; Inês Miranda-Santos; Olivia Bagshaw; Jeffrey Stuart; Paulo J. Oliveira; Teresa Cunha-Oliveira. https://doi.org/10.1101/2021.02.24.432508.
    10.1101/2021.02.24.432508
Activities

Mentoring / Tutoring

Topic Student name
2019/11/08 - 2021/09/30 MitoInformatics - Computational Tools for the Assessment of Mitochondrial Health Sónia Andreia Pinho