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Ana Catarina da Silva Pacheco graduated in Pharmaceutical Sciences (2018), and obtained her PhD in Biomedical Sciences (2025). Currently, she is a Junior Researcher at i3S (Institute for Research and Innovation in Health), working in the Nanomedicines and Translational Drug Delivery group.
Identification

Personal identification

Full name
Ana Catarina Silva Pacheco

Citation names

  • Pacheco, Catarina

Author identifiers

Ciência ID
9519-CF4B-9D7D
ORCID iD
0000-0002-9148-8915

Email addresses

  • acpacheco@i3s.up.pt (Professional)
  • anacatarinaspacheco@hotmail.com (Personal)

Telephones

Mobile phone
  • (+351) 910456991 (Professional)
Telephone
  • (+351) 22607490 Ext.: 6160 (Professional)

Addresses

  • R. Alfredo Allen 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Advanced (C1) Intermediate (B1)
Education
Degree Classification
2020 - 2025
Concluded
 Biomedical Sciences (Doutoramento)
Instituto Universitário de Ciências da Saúde, Portugal
2013/09 - 2018/10/03
Concluded
 Integrated Master in Pharmaceutical Sciences (Mestrado integrado)
Universidade do Porto Faculdade de Farmácia, Portugal
 16/20
Affiliation

Science

Category
Host institution 		Employer
2025/10/01 - Current Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/02 - 2024/08 Visiting Researcher (Research) Instituto de Salud Carlos III, Spain
2023/06 - 2023/07 Visiting Researcher (Research) Fundação Ezequiel Dias, Brazil
2022/08 - 2022/09 Visiting Researcher (Research) Rheinisch Westfälische Technische Hochschule Aachen, Germany

Teaching in Higher Education

Category
Host institution 		Employer
2020 - 2022 Invited Assistant (University Teacher) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal

Positions / Appointments

Category
Host institution 		Employer
2018/10/01 - 2019/12/06 Community Pharmacist Farmácia Porto, Portugal
Outputs

Publications

Book chapter
  1. Moura, Rui; Pacheco, Catarina; Faria, Paulo; Sarmento, Bruno. "Tissue-based in vitro and ex vivo models for blood-brain barrier permeability studies". In Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, edited by Sarmento, Bruno; Leite Pereira, Catarina; das Neves, José. 2024.
    Submitted
  2. Rui Pedro Moura; Catarina Pacheco; Paulo Faria; Bruno Sarmento. "Tissue-based in vitro and ex vivo models for blood–brain barrier permeability studies". 233–249-233–249. Elsevier, 2024.
    10.1016/b978-0-443-15510-9.00022-0
  3. Martins, Cláudia; Pacheco, Catarina; Sarmento, Bruno. "The effect of glioblastoma microenvironment on therapeutic, diagnostic, or theranostic systems". In New Insights Into Glioblastoma, 729-747. Elsevier, 2023.
    10.1016/b978-0-323-99873-4.00022-0
  4. Catarina Pacheco; Ana Baião; Flávia Sousa; Bruno Sarmento. "Implantable and long-lasting drug delivery systems for cancer treatment". 129–162-129–162. Elsevier, 2022.
    10.1016/b978-0-12-821749-8.00011-2
  5. Pacheco, Catarina; Baião, Ana; Sousa, Flávia; Sarmento, Bruno. "Implantable and long-lasting drug delivery systems for cancer treatment". In Long Acting Drug Delivery Systems, edited by Eneko Larrañeta. Elsevier, 2020.
    In press
Conference abstract
  1. Pinto, Soraia; Viegas, Juliana Santos Rosa; Hosseini, Mahya; Cristelo, Cecília; Pacheco, Catarina; Barros, Andreia; van Ijzendoorn, Sven; Santos, Hélder Almeida; Sarmento, Bruno Filipe Carmelino Cardoso. "Bioengineered nanomedicines targeting the intestinal Fc receptor improves the glucorregulatory effect of semaglutide in type 2 diabetic mice". Paper presented in CRS 2024 Annual Meeting and Exposition, Bologna, 2024.
    Published
  2. Pinto, Soraia; Hosseini, Mahia; Viegas, Juliana Santos Rosa; Cristelo, Cecília; Pacheco, Catarina; Barros, Andreia; van Ijzendoorn, Sven; Santos, Hélder Almeida; Sarmento, Bruno Filipe Carmelino Cardoso. "Biodegradable neonatal Fc receptor targeted nanomedicines as innovative peptide delivery system for the treatment of type 2 diabetes". Paper presented in i3S Annual Meeting, Porto, 2023.
    Published
Conference poster
  1. Pinto, Soraia; Viegas, Juliana Santos Rosa; Hosseini, Mahya; Cristelo, Cecília; Pacheco, Catarina; Sofia, Barros; van Ijzendoorn, Sven; Santos, Hélder; Sarmento, Bruno. "Oral delivery of semaglutide through FcRn-targeted nanoparticles for the treatment of type 2 diabetes". Paper presented in 5th SPLC-CRS Young Scientists Meeting, 2025.
  2. Pinto, Soraia; Viegas, Juliana Santos Rosa; Hosseini, Mahya; Cristelo, Cecília; Pacheco, Catarina; Barros, Andreia; van Ijzendoorn, Sven; Santos, Hélder Almeida; Sarmento, Bruno Filipe Carmelino Cardoso. "Bioengineered nanomedicines targeting the intestinal Fc receptor improves the glucoregulatory effect of semaglutide in type 2 diabetic mice". Paper presented in One Health PhD Forum (Instituto de Ciências Biomédicas Abel Salazar), 2024.
  3. Pinto, Soraia; Viegas, Juliana Santos Rosa; Hosseini, Mahya; Cristelo, Cecília; Pacheco, Catarina; Barros, Andreia; van Ijzendoorn, Sven; Santos, Hélder Almeida; Sarmento, Bruno Filipe Carmelino Cardoso. "A multifunctional neonatal Fc receptor targeted nanomedicine for the oral delivery of semaglutide". Paper presented in XVth Spanish-Portuguese Conference on Controlled Drug Delivery - New Horizons in Drug Delivery, 2024.
  4. Pacheco, Catarina; Baltazar, Fátima; Costa, Bruno; Sarmento, Bruno. Corresponding author: Pacheco, Catarina. "Efficacy of AP-9-Modified Nanoparticles Targeting Glioblastoma". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter-Controlled Release Society, 2023.
  5. Pacheco, Catarina; Daware, Rasika, Motta, Alexander; Koikalethu, Anu; Lorenzi, Federica; Sofias, Alexandros Maria; Balta. "CD147-targeted nanomedicine to undermine glioblastoma metabolism". Paper presented in 5th PhDay: Building Paths: The Science Behind Us, 2022.
Journal article
  1. Pacheco, Catarina; Messous, Redouane; Moura, Rui P; Almeida, Andreia; Silva, Patrícia; Sarmento, Bruno; Bousbaa, Hassan; Souza, Júlio C. M.. "Response of murine fibroblasts or human keratinocytes to micro- and nano-scale titanium particles: the permeability of particles across keratinocytes' monolayers". Clinical Oral Investigations 29 10 (2025): https://doi.org/10.1007/s00784-025-06492-1.
    Published • 10.1007/s00784-025-06492-1
  2. Pacheco, Catarina; Dios, Olaya de; Ramiréz-González, Maria Angeles; Martins, Cláudia; Fialho, Sílvia; Baltazar, Fátima; Costa, Bruno; Sanchéz-Gómez, Pilar; Sarmento, Bruno. "Multimodal nanoparticles co-delivering bevacizumab and dichloroacetate for dual targeting of neoangiogenesis and hyperglycolysis in glioblastoma treatment". Journal of Controlled Release 384 (2025): 113931. https://doi.org/10.1016/j.jconrel.2025.113931.
    Open access • Published
  3. Marina F. Dias; Estael L. C. Cruz-Cazarim; Frederico Pittella; Ana Baião; Ana Catarina Pacheco; Bruno Sarmento; Silvia L. Fialho. "Co-delivery of antioxidants and siRNA-VEGF: promising treatment for age-related macular degeneration". Drug Delivery and Translational Research (2025): https://doi.org/10.1007/s13346-024-01772-x.
    10.1007/s13346-024-01772-x
  4. Pinto, Soraia; Viegas, Juliana; Cristelo, Cecília; Pacheco, Catarina; Barros, Andreia S.; Buckley, Stephen T.; Garousi, Javad; et al. "Bioengineered nanomedicines targeting the intestinal Fc receptor achieve the improved glucoregulatory effect of semaglutide in a type 2 diabetic mice model". ACS Nano 18 41 (2024): 28406-28424. http://dx.doi.org/10.1021/acsnano.4c11172.
    Published • 10.1021/acsnano.4c11172
  5. Martins, Cláudia; Pacheco, Catarina; Faria, Paulo; Sarmento, Bruno. "Nanomedicine approaches for treating glioblastoma". Nanomedicine 18 18 (2023): 1135-1138. http://dx.doi.org/10.2217/nnm-2023-0163.
    10.2217/nnm-2023-0163
  6. Catarina Pacheco; Ana Baião; Tao Ding; Wenguo Cui; Bruno Sarmento. "Recent advances in long-acting drug delivery systems for anticancer drug". Advanced Drug Delivery Reviews 194 (2023): 114724-114724. http://dx.doi.org/10.1016/j.addr.2023.114724.
    10.1016/j.addr.2023.114724
  7. Martins, Cláudia; Marco Araújo; Malfanti, Alessio; Pacheco, Catarina; Smith, Stuart J.; Ucakar, Bernard; Rahman, Ruman; et al. "Stimuli-Responsive Multifunctional Nanomedicine for Enhanced Glioblastoma Chemotherapy Augments Multistage Blood-to-Brain Trafficking and Tumor Targeting". Small (2023): 2300029. http://dx.doi.org/10.1002/smll.202300029.
    10.1002/smll.202300029
  8. Cláudia Martins; Catarina Pacheco; Catarina Moreira-Barbosa; Ângela Marques-Magalhães; Sofia Dias; Marco Araújo; Maria J. Oliveira; Bruno Sarmento. "Glioblastoma immuno-endothelial multicellular microtissue as a 3D in vitro evaluation tool of anti-cancer nano-therapeutics". Journal of Controlled Release 353 (2023): 77–95-77–95. http://dx.doi.org/10.1016/j.jconrel.2022.11.024.
    10.1016/j.jconrel.2022.11.024
  9. Martins, Cláudia; Pacheco, Catarina; Moreira-Barbosa, Catarina; Marques-Magalhães, Ângela; Dias, Sofia; Araújo, Marco; O. "Glioblastoma immuno-endothelial multicellular microtissue as a 3D in vitro evaluation tool of anti-cancer nano-therapeutics". Journal of Controlled Release 353 (2023): 77-95. https://doi.org/10.1016/j.jconrel.2022.11.024.
    Published
  10. Faria, Paulo; Pacheco, Catarina; Moura, Rui Pedro; Sarmento, Bruno; Martins, Cláudia. "Multifunctional nanomedicine strategies to manage brain diseases". Drug Delivery and Translational Research (2022): http://dx.doi.org/10.1007/s13346-022-01256-w.
    10.1007/s13346-022-01256-w
  11. Pinto, Bárbara; Pacheco, Catarina; Patricia Silva; Carvalho-Tavares, Juliana; Bruno Sarmento; Bousbaa, Hassan. "Nanomedicine internalization and penetration: why should we use spheroids?". Scientific Letters (2022): https://doi.org/10.48797/sl.2022.12.
    Published
  12. Catarina Pacheco; Cláudia Martins; Joaquim Monteiro; Fátima Baltazar; Bruno M. Costa; Bruno Sarmento. "Glioblastoma Vasculature: From its Critical Role in Tumor Survival to Relevant in Vitro Modelling". Frontiers in Drug Delivery (2022): https://doi.org/10.3389/fddev.2022.823412.
    10.3389/fddev.2022.823412
  13. Pacheco, Catarina; Baltazar, Fátima; M. Costa, Bruno; Sarmento, Bruno. "Bringing vascularization into glioblastoma in vitro models". Trends in Molecular Medicine (2021): https://doi.org/10.1016%2Fj.molmed.2021.11.001.
    10.1016/j.molmed.2021.11.001
  14. Moura, Rui Pedro; Pacheco, Catarina; Pêgo, Ana Paula; des Rieux, Anne; Sarmento, Bruno. "Lipid nanocapsules to enhance drug bioavailability to the central nervous system". Journal of Controlled Release (2020): http://dx.doi.org/10.1016/j.jconrel.2020.03.042.
    10.1016/j.jconrel.2020.03.042
  15. Pacheco, Catarina; Sousa, Flávia; Sarmento, Bruno. "Chitosan-based nanomedicine for brain delivery: Where are we heading?". Reactive and Functional Polymers 146 (2020): 104430. http://dx.doi.org/10.1016/j.reactfunctpolym.2019.104430.
    10.1016/j.reactfunctpolym.2019.104430
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07/11 Addressing metabolic switch and limited tumor accumulation in glioblastoma antiangiogenic therapy using multidrug polymeric nanoparticles Controlled Release Society Annual Meeting and Exposition
CRS (Italy)
2023/02/23 How CD147-specific nanomedicines end: from target engagement in 2D towards validation using a novel vascularized in vitro glioblastoma model 2nd CA17140 STSM VIRTUAL CONFERENCE
COST Action CA17140 (Nano2Clinic), supported by COST (European Cooperation in Science and Technology) within STSM program

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/02/23 - 2023/02/23 2nd CA17140 STSM VIRTUAL CONFERENCE (2023/02/23 - 2023/02/23)
Conference (Member of the Organising Committee)
2022/01/01 - 2022/10/04 5th PhDay: Building Paths: The Science Behind Us (2022/10/03 - 2022/10/04)
Conference (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/05/08 - 2033/05/19 Advanced Course In Laboratory Animal Science
Workshop
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/12/05 - 2023/12/07 Experimental Design and Analysis of Data from Animal Experiments
Workshop
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/02/06 - 2023/02/07 4th SPLC-CRS Young Scientists Meeting
Conference
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/02/26 - 2022/05/16 Blended Learning Introduction to Clinical Studies
Workshop
Universidade do Porto Faculdade de Medicina, Portugal
2022/04/27 - 2022/04/29 8th International Galenus Workshop Valencia
Workshop
Universitat de València, Spain

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/06/22 Study of nephrotoxicity biomarkers resulting from exposure to therapeutic doses of tramadol
(Thesis) Main arguer
 Márcia Silva (Other)
Instituto Universitário de Ciências da Saúde, Portugal
2021/06/03 The effectiveness of combined therapy of PLK-1 inhibitor and Navitoclax for increased lung cancer cell death
(Thesis) Main arguer
 Inês Maria Teixeira Magalhães (Other)
Instituto Universitário de Ciências da Saúde, Portugal

Committee member

Activity description
Role 		Institution / Organization
2020 - 2021 Monitoring Committee of the DoctoralProgram in Biomedical Sciences of University Institute of Health Sciences
Member
 Instituto Universitário de Ciências da Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - 2022 Biochemistry Biomedical Sciences (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2020 - 2022 Biomedical and biotechnological techniques Biomedical Sciences (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
Distinctions

Award

2024 Best Oral Communication
Spanish Portuguese Local Chapter - Controlled Release Society, Spain
2023 Best Poster Communication
PhD Day - Scientific Innovation: Challenges in Health and Environment issues, Portugal

Other distinction

2023 Trainee Grant Scholarship (1.200€)
Nano2Clinic COST Action 17140, Poland
2022 Short-term Scientific Mission Grant (3.000€)
Nano2Clinic COST Action 17140, Poland