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Luciano Santos (LS) is a young researcher born in 1997 at Funchal, Madeira. He holds a degree and a master's degree in Biochemistry from the Faculty of Sciences (FCUP) and the Abel Salazar Biomedical Sciences Institute (ICBAS) of Porto University. LS received one of the highest final grades in the biochemistry degree program, earning distinction as one of the top students. For his degree project, LS focused on the computational study of the catalytic mechanism of the brain enzyme DOPA decarboxylase, an important pharmacological target for the treatment of neurodegenerative disease. This project provided him with relevant bioinformatic skills such as molecular dynamics simulations, molecular docking, or QM/MM hybrid methods. LS completed a master’s dissertation in organic chemistry field, with supervision from Dr. Ivo Dias (LAQV/REQUIMTE) and Prof. Enrique Borgez (FCUP). His dissertation aimed to enhance the efficacy of melanostatin, a neuropeptide that exhibits anti-Parkinson's activity, by designing peptidomimetics with improved oral bioavailability and pharmacological activity. LS developed an innovative methodology using the reactivity of amino acid functional groups to synthesize the first macrocyclic analogues of melanostatin described. In addition, LS also contributed to other ongoing projects, including the development of a novel method for synthesizing N-functionalized glycines and peptoid analogues of melanostatin. LS's work involved a range of laboratory techniques, such as liquid phase peptide coupling or olefin metathesis as well as various separation methods, including extraction, precipitation of aminoacids and peptides or purification by column liquid chromatography. Analytical work, such as interpreting nuclear magnetic resonance (NMR) and high-resolution mass spectra (HRMS), was also a part of his research. These research findings are currently being incorporated into a manuscript that will be submitted soon for publication in an international journal. In August 2022, LS started a voluntary internship in CIIMAR - Interdisciplinary Centre of Marine and Environmental Research under the supervision of Prof. Luisa Valente. LS has gained interest in the fish nutrition area which led him to apply for a research position under the project OmegaPeixe, in collaboration with industrial partners (FlatAtlantic). The project aims to fortify fish in fatty acids such as DHA and EPA in order to provide consumers the recommended level to ensure cardiovascular protection. LS has gained autonomy in all laboratory analysis related to this project, in particularly the chemical characterization of ingredients, diets and biological samples. Furthermore, LS has become increasingly interested in the use of functional diets able to improving fish quality for consumption in the sense of promoting human health. To achieve this, he has been evaluating new ingredients using tools to evaluate their antioxidant (ABTS and ORAC) and antimicrobial (bactericidal/bacteriostatic activities) properties. Moreover, LS obtained certification for aquatic animal experimentation (FELASA category B) to carry out in vivo experimental work following best practices. His multidisciplinary background and laboratory skills make him a promising researcher able to easily adapt to any area of scientific research from chemistry to biology.
Identification

Personal identification

Full name
Luciano Eduardo Rodrigues dos Santos
Date of birth
1997/09/14
Gender
Male

Citation names

  • Santos, Luciano

Author identifiers

Ciência ID
9510-E3C7-EED8

Email addresses

  • lers.eduardo.97@gmail.com (Professional)
  • up201504675@fc.up.pt (Professional)

Telephones

Mobile phone
  • (+351) 933386845 (Personal)

Addresses

  • CIIMAR - Interdisciplinary Centre of Marine and Environmental Research of the University of Porto, LANUCE. Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos, S/N, 4450-208, Matosinhos, Matosinhos, Portugal (Professional)

Knowledge fields

  • Natural sciences - Earth and Environmental Sciences - Water Resources
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Computer and Information Sciences - Bioinformatics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2023
Concluded
CAL-AQUA - Laboratory Aquatic Animal Science Course (42 h) (Outros)
Major in FELASA B Category
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Excellent
2022
Concluded
Biochemistry (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Synthesis and Pharmacological Evaluation of Melanostatin Macrocyclic Derivatives; Classification: 18 " (THESIS/DISSERTATION)
18
2020
Concluded
Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Computational study of the enzymatic mechanism of aromatic amino acid L decarboxylase (AADC), enzyme involved in melatonin synthesis; Classification: 19" (THESIS/DISSERTATION)
17
2015
Concluded
Sciences and Technology (Ensino secundário)
Escola Secundária Jaime Moniz, Portugal
18
Affiliation

Science

Category
Host institution
Employer
2022/09/01 - Current Researcher (Research) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
(...)
2021/10/10 - 2022/12/13 Research Trainee (Research) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2022/08/03 - 2022/08/31 Research Trainee (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2018/10/05 - 2019/06/30 Research Trainee (Research) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
Projects

Contract

Designation Funders
2022/09/01 - 2025/12/31 Blue Bioeconomy Pact-Vertical FEED
C644915664-00000026
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Ongoing
2022/09/01 - 2023/06/30 OMEGAPEIXE - Fortification of farmed fish with long chain Omega-3 fatty acids.
AAC nº 17/SI/2019
Researcher
Centro Interdisciplinar de Investigação Marinha e Ambiental da Madeira, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Flatlantic, Portugal
Ongoing
Outputs

Publications

Conference poster
  1. Santos, Luciano; Ivo E. Sampaio-Dias; Santana, Renata; Sara C. Silva-Reis; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Macrocyclization of Melanostatin Neuropeptide by Ring-Closing Metathesis". Paper presented in 15th Young Researchers Meeting at the University of Porto (IJUP'22), 2022.
  2. Santana, Renata; Ivo E. Sampaio-Dias; Santos, Luciano; Sara C. Silva-Reis; García-Mera, Xerardo; Borges, José. "A New Methodology for the Synthesis of N-functionalized Glycines: Assembly of Melanostatin-Based Peptoids". Paper presented in 15th Young Researchers Meeting at the University of Porto (IJUP'22), 2022.
  3. Santos, Luciano; Neves, Rui P. P.. "Computational study of the reaction mechanism of the aromatic L-amino acid decarboxylase, an enzyme involved on the biosynthesis of serotonin and melatonin". Paper presented in 12th Young Researchers Meeting at the University of Porto (IJUP 2019), 2019.
Thesis / Dissertation
  1. "Synthesis and Pharmacological Evaluation of Melanostatin Macrocyclic Derivatives". Master, Universidade do Porto Faculdade de Ciências, 2022.
  2. "Computational study of the enzymatic mechanism of aromatic L-amino acid decarboxylase (AADC), enzyme involved in melatonin synthesis". Degree, Universidade do Porto Faculdade de Ciências, 2019.
Activities

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/09/15 - 2022/09/15 Animal Science Doctoral Programe - VIII Workshop
Conference
Animal Science Doctoral Programe
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/05/04 - 2022/05/06 15º Young Researchers Meeting at the University of Porto
Meeting
IJUP’22
Universidade do Porto, Portugal
2019/02/13 - 2019/02/15 12º Young Researchers Meeting at the University of Porto
Meeting
IJUP'19
Universidade do Porto, Portugal
2018/09/18 - 2018/09/18 Animal Science Doctoral Programme - V Workshop
Conference
Animal Science Doctoral Programme
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/03/21 - 2018/03/21 Contribuição da biologia molecular para o diagnóstico dos tumores do córtex da supra-renal
Conference
VI Ciclo de Conferências de Divulgação Científica FFUP/ICBAS
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/03/14 - 2018/03/14 Uma saúde, respostas globais para problemas globais
Conference
VI Ciclo de Conferências de Divulgação Científica FFUP/ICBAS
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/03/07 - 2018/03/07 Revelando os segredos da microbiota urinária: impacto nas doenças do trato urinário
Conference
VI Ciclo de Conferências de Divulgação Científica FFUP/ICBAS
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/03/22 - 2017/03/22 As disfunções metabólicas na Doenças de Alzheimer: desafios científicos e novas estratégias terapêuticas
Conference
V Ciclo de Conferências de Divulgação Científica FFUP/ICBAS
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Distinctions

Award

2020 Reconhecimento da média final em Licenciatura em Bioquímica - Cerimónia de Entrega de Prémios e Distinções FCUP 2020
Universidade do Porto Faculdade de Ciências, Portugal