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Mariana Mesquita holds a PhD in Biochemistry from the University of Aveiro, Portugal. During this period, her research was focused on the evaluation of a set of synthetic reduced porphyrinoid photoactive compounds for prostate cancer applications. In fact, these compounds possess some important features that bring essential properties for a potential photosensitizer in photodynamic therapy of cancer cells. As a result of this intense work, she published 11 original papers in international peer-reviewed journals, and 1 book chapter. In addition, she participated in international conferences, where she had the opportunity to perform 11 oral presentations (4 as presenting author and 7 as co-author) and present 13 poster communications.
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Identification

Personal identification

Full name
Mariana Queirós Mesquita

Citation names

  • Mesquita, Mariana

Author identifiers

Ciência ID
9416-2C19-26FE
ORCID iD
0000-0003-1570-1582

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2016/09/01 - 2022/02/23
Concluded
 Bioquímica (Doutoramento)
Universidade de Aveiro, Portugal
"Terapia fotodinâmica no cancro da próstata usando derivados porfirínicos reduzidos" (THESIS/DISSERTATION)
 Approved
2011/09/01 - 2013/12/12
Concluded
 Bioquímica (Mestrado integrado)
Major in Métodos Biomoleculares
Universidade de Aveiro, Portugal
"Síntese e atividade antibacteriana de clorinas e isobacterioclorinas" (THESIS/DISSERTATION)
 17
2008/09/01 - 2011/07/01
Concluded
 Biociências (Licenciatura)
Major in Bioquímica
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
"Biological and technological functions of Ulvan, extracted from green macroalgae" (THESIS/DISSERTATION)
 14
Affiliation

Others

Category
Host institution 		Employer
2016/09/01 - 2022/02/23 Bolseira de Doutoramento Universidade de Aveiro, Portugal
Universidade de Aveiro, Portugal
Outputs

Publications

Book chapter
  1. Mesquita, Mariana; Dias, Cristina J.; Neves, Maria G. P. M. S.; Almeida, Adelaide; M. Amparo F. Faustino. "The Role of Photoactive Materials Based on Tetrapyrrolic Macrocycles in Antimicrobial Photodynamic Therapy". In Handbook of Porphyrin Science, edited by Karl M. Kadish; Kevin M. Smith; Roger Guilard, 201-277. World Scientific, 2022.
    Published • 10.1142/9789811246760_0221
Conference poster
  1. Mesquita, Mariana; Ferreira, Ana Rita; Neves, Graça G.P.M.S; Fardilha, Margarida; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Polyvinylpyrrolidone formulations of porphyrinoids as photosensitizers for Photodynamic Therapy of prostate cancer.". Paper presented in 19th Congress of the European Society for Photobiology, 2021.
  2. Mesquita, Mariana; Neves, Maria G. P. M. S.; Fardilha, Margarida; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Photodynamic Therapy of prostate cancer using chlorin and isobacteriochlorin derivatives.". Paper presented in 13th National Organic Chemistry Meeting – 6th National Medicinal Chemistry Meeting, 2020.
  3. Joaquinito, A. Sofia; Dias, Cristina J.; Monteiro, Carlos J. P.; Mesquita, Mariana; Neves, Maria G. P. M. S.; Tessari, Francesco; Miolo, Giorgia; M. Amparo F. Faustino. "5,10,15,20- Tetrakis(pentafluorophenyl)porphyrin: a versatile platform on the preparation of biologically active photosensitizers.". Paper presented in 13th National Organic Chemistry Meeting – 6th National Medicinal Chemistry Meeting, 2020.
  4. Dias, Cristina J.; Mesquita, Mariana; Moura, Nuno M. M.; Gomes, Ana T.P.C.; Neves, Maria G. P. M. S.; Almeida, Adelaide; Cunha, Angela; M. Amparo F. Faustino. "Tetrapyrrolic-sugar conjugates and their potential applications". Paper presented in 1st Meeting COST ACTION 18132, 2019.
  5. Mesquita, Mariana; Neves, Maria G. P. M. S.; Fardilha, Margarida; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Chlorin and isobacteriochlorin derivatives as potential photosensitizing agents for Photodynamic Therapy.". Paper presented in 17th International Congress on Photobiology and 18th Congress of the European Society for Photobiology, 2019.
  6. Silva, Leonardo P.; Gomes, Ana T. P. C.; Mesquita, Mariana; Neves, Maria G. P. M. S.; M. Amparo F. Faustino; Almeida, Adelaide; Braga, G.U.L.; Sant’Ana, A. S.. "Photodynamic treatment as an alternative for Alicyclobacillus Spp. Inactivation". Paper presented in International Association for Food Protection Annual Meeting, 2019.
  7. Mesquita, Mariana; Castro, Kelly A.D.F.; Moura, Nuno M. M.; Silvestre, A. J. D.; Simões, Mário M. Q.; Cavaleiro, J. A. S.; Silva, R. S.; et al. "Synthesis and characterization of PS-polymer materials for antimicrobial approaches.". Paper presented in 12th National Organic Chemistry Meeting and the 5th National Medicinal Chemistry Meeting, 2018.
  8. Mesquita, Mariana; Neves, Maria G. P. M. S.; Fardilha, Margarida; M. Amparo F. Faustino. "Glycoporphyrin and glycochlorin derivatives: A comparative study.". Paper presented in 17th Congress of the European Society for Photobiology, 2017.
  9. Mesquita, Mariana; Menezes, José C.J.M.D.S.; Neves, Maria G. P. M. S.; Cavaleiro, J. A. S.; Cunha, Ângela; Almeida, Adelaide; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Photodynamic inactivation of bioluminescent E. coli.". Paper presented in 16th Congress of the European Society for Photobiology, 2015.
  10. Mesquita, Mariana; Menezes, José C.J.M.D.S.; M. Amparo F. Faustino; Neves, Maria G. P. M. S.; Tomé, A. C.; Cunha, Ângela; Almeida, Adelaide; et al. Corresponding author: Cavaleiro, J. A. S.. "Photodynamic inactivation of bioluminescent Escherichia coli by cationic pyrrolidine-fused chlorins and isobacteriochlorins.". Paper presented in The 37th Annual Meeting of the Brazilian Chemical Society, 2014.
  11. Mesquita, Mariana; Menezes, José C.J.M.D.S.; Neves, Maria G. P. M. S.; Tomé, A. C.; Cavaleiro, J. A. S.; Cunha, Ângela; Almeida, Adelaide; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Isobacteriochlorin derivative of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin on the photodynamic inactivation of bioluminescent E. coli.". Paper presented in 10th Portuguese National Meeting of Organic Chemistry and the 1st Portuguese-Brazilian Organic Chemistry Symposium, 2013.
  12. Mesquita, Mariana; Menezes, José C.J.M.D.S.; Neves, Maria G. P. M. S.; Tomé, A. C.; Cavaleiro, J. A. S.; Cunha, Ângela; Almeida, Adelaide; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Photodynamic inactivation of bioluminescent E. coli by immobilized chlorin derivatives.". Paper presented in 15th Congress of the European Society for Photobiology, 2013.
  13. Mesquita, Mariana; Menezes, José C.J.M.D.S.; Neves, Maria G. P. M. S.; Tomé , A. C.; Cavaleiro, J. A. S.; Cunha, Ângela; Almeida, Adelaide; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Neutral and cationic chlorin and isobacteriochlorin derivatives of 5,10,15,20- tetrakis(pentafluorophenyl)porphyrin on the photodynamic inactivation of bioluminescent E.coli". Paper presented in XXIII National Meeting of Portuguese Chemical Society, 2013.
Journal article
  1. Mesquita, Mariana; Ferreira, Ana Rita; Neves, Maria da Graça P.M.S.; Ribeiro, Daniela; Fardilha, Margarida; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Photodynamic therapy of prostate cancer using porphyrinic formulations". Journal of Photochemistry and Photobiology B: Biology 223 (2021): 112301. http://dx.doi.org/10.1016/j.jphotobiol.2021.112301.
    Published • 10.1016/j.jphotobiol.2021.112301
  2. Castro, Kelly A.D.F.; Ramos, Loyanne; Mesquita, Mariana; Biazzotto, Juliana Cristina; Moura, Nuno M. M.; Mendes, Ricardo F.; Almeida Paz, Filipe A.; et al. Corresponding author: da Silva, Roberto S.. "Comparison of the Photodynamic Action of Porphyrin, Chlorin, and Isobacteriochlorin Derivatives toward a Melanotic Cell Line". ACS Applied Bio Materials 4 6 (2021): 4925-4935. http://dx.doi.org/10.1021/acsabm.1c00218.
    Published • 10.1021/acsabm.1c00218
  3. Braz, Márcia; Salvador, Diana; Gomes, Ana T.P.C.; Mesquita, Mariana; M. Amparo F. Faustino; Neves, M. Graça P.M.S.; Almeida, Adelaide. Corresponding author: Almeida, Adelaide. "Photodynamic inactivation of methicillin-resistant Staphylococcus aureus on skin using a porphyrinic formulation". Photodiagnosis and Photodynamic Therapy 30 (2020): 101754. http://dx.doi.org/10.1016/j.pdpdt.2020.101754.
    Published • 10.1016/j.pdpdt.2020.101754
  4. Vieira, Cátia; Santos, Adriele; Mesquita, Mariana; Gomes, Ana T. P. C.; Neves, M. Graça P. M. S.; M. Amparo F. Faustino; Almeida, Adelaide. Corresponding author: Almeida, Adelaide. "Advances in aPDT based on the combination of a porphyrinic formulation with potassium iodide: Effectiveness on bacteria and fungi planktonic/biofilm forms and viruses". Journal of Porphyrins and Phthalocyanines 23 04n05 (2019): 534-545. http://dx.doi.org/10.1142/s1088424619500408.
    Published • 10.1142/s1088424619500408
  5. Vieira, Cátia; Gomes, Ana T. P. C.; Mesquita, Mariana; Moura, Nuno M. M.; Neves, M. Graça P. M. S.; M. Amparo F. Faustino; Almeida, Adelaide. Corresponding author: Almeida, Adelaide. "An Insight Into the Potentiation Effect of Potassium Iodide on aPDT Efficacy". Frontiers in Microbiology 9 (2018): 2665. http://dx.doi.org/10.3389/fmicb.2018.02665.
    Published • 10.3389/fmicb.2018.02665
  6. Mesquita, Mariana; J. Dias, Cristina; P. M. S. Neves, Maria; Almeida, Adelaide; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy". Molecules 23 10 (2018): 2424. http://dx.doi.org/10.3390/molecules23102424.
    Published • 10.3390/molecules23102424
  7. Marciel, Lúcia; Mesquita, Mariana; Ferreira, Rosalina; Moreira, Beatriz; PMS Neves, Maria Graça; M. Amparo F. Faustino; Almeida, Adelaide. Corresponding author: Almeida, Adelaide. "An efficient formulation based on cationic porphyrins to photoinactivate Staphylococcus aureus and Escherichia coli". Future Medicinal Chemistry 10 15 (2018): 1821-1833. http://dx.doi.org/10.4155/fmc-2018-0010.
    Published • 10.4155/fmc-2018-0010
  8. Martins, Diana; Mesquita, Mariana; Neves, Maria G. P. M. S.; M. Amparo F. Faustino; Reis, Luís; Figueira, Etelvina; Almeida, Adelaide. "Photoinactivation of Pseudomonas syringae pv. actinidiae in kiwifruit plants by cationic porphyrins". Planta 248 2 (2018): 409-421. http://dx.doi.org/10.1007/s00425-018-2913-y.
    Published • 10.1007/s00425-018-2913-y
  9. Mesquita, Mariana; DIAS, CRISTINA J.; GAMELAS, SARA; Fardilha, Margarida; NEVES, MARIA G.P.M.S.; M. Amparo F. Faustino. Corresponding author: M. Amparo F. Faustino. "An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy". Anais da Academia Brasileira de Ciências 90 1 suppl 2 (2018): 1101-1130. http://dx.doi.org/10.1590/0001-3765201720170800.
    Published • 10.1590/0001-3765201720170800
  10. Mesquita, Mariana; Menezes, José C.J.M.D.S.; Pires, Sónia M.G.; Neves, Maria G.P.M.S.; Simões, Mário M.Q.; Tomé, Augusto C.; Cavaleiro, José A.S.; et al. Corresponding author: Faustino, M. Amparo F.. "Pyrrolidine-fused chlorin photosensitizer immobilized on solid supports for the photoinactivation of Gram negative bacteria". Dyes and Pigments 110 (2014): 123-133. http://dx.doi.org/10.1016/j.dyepig.2014.04.025.
    Published • 10.1016/j.dyepig.2014.04.025
  11. Mesquita, Mariana; Menezes, José C.J.M.D.S.; Neves, Maria G.P.M.S.; Tomé, Augusto C.; Cavaleiro, José A.S.; Cunha, Ângela; Almeida, Adelaide; et al. Corresponding author: M. Amparo F. Faustino. "Photodynamic inactivation of bioluminescent Escherichia coli by neutral and cationic pyrrolidine-fused chlorins and isobacteriochlorins". Bioorganic & Medicinal Chemistry Letters 24 3 (2014): 808-812. http://dx.doi.org/10.1016/j.bmcl.2013.12.097.
    Published • 10.1016/j.bmcl.2013.12.097
Thesis / Dissertation
  1. "Terapia fotodinâmica no cancro da próstata usando derivados porfirínicos reduzidos". PhD, Universidade de Aveiro, 2022.
  2. "Síntese e atividade antibacteriana de clorinas e isobacterioclorinas". Master, Universidade de Aveiro, 2013.
  3. "Biological and technological functions of Ulvan, extracted from green macroalgae". Degree, Universidade Católica Portuguesa Escola Superior de Biotecnologia, 2011.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/09/02 Effect of oxidative states on the efficiency of porphyrinoids in Photodynamic Therapy of prostate cancer 19th Congress of the European Society for Photobiology
European Society for Photobiology (Salzburg, Austria)
2020/06/24 Photodynamic therapy in prostate cancer using chlorin and isobacteriochlorin photosensitizers Research Summit 2020
Universidade de Aveiro (Aveiro, Portugal)
2019/09/17 Photodynamic treatment of orange (Citrus sinensis L. Osbeck) peel: Alicyclobacillus spp. inactivation and effects on colorimetric characteristics 11th International Conference of Predictive Modelling in Food
(Bragança, Portugal)
2019/08/25 An efficient formulation based on cationic porphyrins to photoinactivate gram positive and gram negative bacteria: in vitro and ex vivo evaluation 17th Congress of the International Union of Photobiology and 18th Congress of the European Society for Photobiology
European Society for Photobiology (Barcelona, Spain)
2019/08/25 An insight into the potentiation effect of potassium iodide on antimicrobial PDT efficacy 17th Congress of the International Union of Photobiology and 18th Congress of the European Society for Photobiology
European Society for Photobiology (Barcelona, Spain)
2019/05/03 Photodynamic therapy in prostate cancer and metastatic malignant melanoma using chlorin photosensitizers Research Summit 2019
Universidade de Aveiro (Aveiro, Portugal)
2018/11/29 Photodynamic therapy in prostate cancer and metastatic malignant melanoma using chlorin photosensitizers Research Summit 2018
Universidade de Aveiro (Aveiro, Portugal)
2018/11/21 Novel porphyrin-flavone conjugates: synthesis and photophysical characterization. XXIV Encontro Luso-Galego de Qu mica
Sociedade Portuguesa de Química (Porto, Portugal)
2017/12/04 Recent synthetic approaches for the development of photosensitizers for photodynamic therapy 2nd International Caparica Christmas Conference on Translational Chemistry
(Costa da Caparica, Portugal)
2017/11/22 Recent development on porphyrinic chemistry and applications 9th Trans Mediterranean Colloquium on Heterocyclic Chemistry
(Fez, Morocco)
2015/09/02 Development of photoactive materials for environmental applications 16th Congress of the European Society for Photobiology
European Society for Photobiology (Aveiro, Portugal)
2013/11/27 Second generation of antimicrobial photosensitizers based on 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin 7th Trans mediterranean Colloquium on Heterocyclic Chemistry
(Rabat, Morocco)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/10/10 - 2019/10/12 Exposição no TechDays 2019 com um stand intitulado "Química, Saúde e Ambiente: Do composto às aplicações"
Exhibition
 TechDays 2019
Universidade de Aveiro, Portugal
2018/10/11 - 2018/10/13 Exposição no TechDays 2018 com um stand intitulado "Cancro e infeções microbianas: novas abordagens terapêuticas"
Exhibition
 TechDays 2018
Universidade de Aveiro, Portugal

Mentoring / Tutoring

Topic Student name
2018/01/02 - 2018/06/29 Novel Porphyrin-based conjugates: Synthesis and Photophysical characterization Francesco Tessari