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Patrícia Bacalhau has a background in supramolecular chemistry and biochemical mechanisms of neurodegenerative diseases, holds a degree in Biochemistry from the University of Algarve (Portugal), an MSc degree in Chemistry Teaching and a Ph.D. in Biochemistry from the University of Évora. Her training in molecular synthesis started in 1999 as a student at ITQB, where Patrícia developed lanthanide coordinated crown azamacrocycles (radiolabelled with 153Sm) for therapeutic use in bone cancer (Portugal). During her Ph.D research, Patrícia engaged the study of the biochemical mechanisms involved in Alzheimer’s and Parkinson’s diseases. Her main results involved the discovery of a lead compound with therapeutic benefits for AD. Her Ph.D. was successfully completed in 4 years. During this time, Patrícia published several peer reviewed papers, a patent and her investigation also produced numerous presentations in international congresses. Since 2022, she has been working as a research manager in the LABscape group at the University of Évora, where Patrícia gained extensive experience in proposal preparation, budgeting and scientific and financial reporting, as well as in coordinating large, multidisciplinary teams. Patrícia organised two major international congresses with more than 300 participants and is currently co organising a third congress expected to receive around 400 participants. In parallel, Patrícia has been teaching Human and General Biochemistry to undergraduate students and supervising several undergraduate projects in biochemistry and biotechnology laboratories.
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Identification

Personal identification

Full name
Patrícia Alexandra Anico Gazimba Bacalhau

Citation names

  • Bacalhau, Patrícia
  • Bacalhau, P.

Author identifiers

Ciência ID
9413-39DE-C1AF
ORCID iD
0000-0002-4769-7437

Email addresses

  • pbacall@uevora.pt (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2018/01/30
Concluded
 PhD in Biochemistry (Doutoramento)
Universidade de Évora Instituto de Investigação e Formação Avançada, Portugal
"Biochemical mechanisms and target drugs in neurodegenerative diseases" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2011
Concluded
 Teaching Physics and Chemistry in High School (Mestrado)
Universidade de Évora, Portugal
"Prática de Ensino Supervisionada na área da especialização do Mestrado em Ensino de Física e Química" (THESIS/DISSERTATION)
 16
2005
Concluded
 Legal medicine and forensic sciences (Pós-Graduação)
Universidade de Lisboa Faculdade de Medicina, Portugal
 13
2001
Concluded
 Biochemistry (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Macrocycles and its aplications to medicine: Synthesis and study of some of its complexes" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2022/06 - Current Invited Auxiliary Researcher (Research) Instituto Mediterrâneo para a Agricultura Ambiente e Desenvolvimento, Portugal
Universidade de Évora, Portugal
2014 - 2015 Contracted Researcher (Research) Universidade de Évora Centro de Química de Évora, Portugal

Other Careers

Category
Host institution 		Employer
2015/09/01 - 2022/08/31 Professor do ensino básico e secundário (Professor do ensino básico e secundário) Ministério da Educação, Portugal

Others

Category
Host institution 		Employer
2001/09/15 - 2002/08/31 Technician responsible for the dissemination and implementation of generic medicines at the level of health centers in mainland Portugal. Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
Projects

Grant

Designation Funders
2027/01/01 - 2029/12/31 Rational design of BACE-1 inhibitors as disease-modifying candidates for Alzheimer’s disease
2025.15157.CEECIND
Post-doc Fellow
Under evaluation

Contract

Designation Funders
2023/09/01 - 2026/12/31 SOS_PRODEHESAMONTADO - Modelos de sostenibilidad integral y resiliencia de la dehesa-montado frente a las amenazas climáticas
3.ª Convocatória POCTEP - OP2 Uma Europa mais verde e carbonicamente neutra | OE2.7.
Researcher
Universidade de Évora, Portugal
Ongoing
2024/01/01 - 2025/12/31 Montados Net-Zero - Redes de inovação para aumentar resiliência e progredir para a neutralidade carbónica nos espaços rurais do Sul
PRR-C05-i03-I-000236
Researcher
Universidade de Évora, Portugal
Concluded
2014 - 2015 INMOLFARM - Molecular Innovation and Drug Discovery
ALENT-57-2011-20
Research Fellow
Universidade de Évora Centro de Química de Évora, Portugal
Concluded
Outputs

Publications

Conference abstract
  1. Bacalhau, Patrícia. "Computational studies with oxindole frameworks". 2018.
    Published
  2. Bacalhau, Patrícia. "Synthesis of a-glucosidases and cholinesterases inhibitors". 2017.
    Published
  3. Bacalhau, Patrícia; Fernandes, Luís; Burke, A.J.. "From a-glucosidases to cholinesterases inhibition - Synthesis, SAR, STD-NMR". Paper presented in XXII Encontro Luso-Galego de Química, 2016.
  4. Bacalhau, Patrícia. "Inhibition Study of MAO-B Activity: Comparing Two Different Techniques". Paper presented in Microbiotec, 2015.
    Published
  5. Bacalhau, Patrícia. "Oxindole Derivatives as Cholinesterase Inhibitors for Alzheimer’s Disease". Paper presented in Microbiotec, 2015.
    Published
  6. Bacalhau, Patrícia. "Targetting Cholinesterases for the Treatment of Alzheimer’s Disease: Synthesis and Structure-Activity Relationship Study of Indolinone Analogues". Paper presented in SPJ-OCS, 2015.
    Published
  7. Bacalhau, Patrícia. "From a-Glucosidases to Cholinesterases Inhibition via QSAR and Docking Studies". Paper presented in SPJ-OCS, 2015.
    Published
  8. Bacalhau, Patrícia. "The role of Cholinesterases in Alzheimer’s Disease: Screening of Target Compounds". 2015.
    Published
  9. Bacalhau, Patrícia. "The Role of Acetylcholinesterase in Alzheimer’s Disease: Enzymatic inhibition studies". Paper presented in Congress of the Portuguese Biochemical Society, 2014.
    Published
  10. Bacalhau, Patrícia. "New Chiral Analogues for Neurodegenerative Diseases: The power of metal catalysis". Paper presented in International Symposium on Medicinal Chemistry, 2014.
    Published
Conference poster
  1. Bacalhau, Patrícia. "Computational studies with oxindole frameworks". 2018.
  2. Bacalhau, Patrícia. "Synthesis of a-glucosidases and cholinesterases inhibitors". Paper presented in ISYSYCAT 2017, 2017.
  3. BURKE, Anthony; Marques, Carolina Silva; Carreiro, Elisabete P.; Fernandes Luis G; Guedes, Rita C.; Bacalhau, Patrícia. "Synthesis of Alpha-Glucosidase and Cholinesterase Inhibitors". Paper presented in International Symposium on Synthesis and Catalysis 2017, 2017.
  4. Bacalhau, Patrícia. "From a-glucosidases to cholinesterases inhibition - Synthesis, SAR, STD-NMR". 2016.
  5. BURKE, Anthony; Fernandes Luis G; Bacalhau, Patrícia; Guedes, Rita C.; A. Teresa Caldeira; Martins Rosário Maria; Amor San Juan. "From a-glucosidases to cholinesterases inhibition – synthesis, SAR, STD-NMR and docking studies". Paper presented in XXII Encontro Luso-Galego de Química, 9-11 Nov. 2016, Bragança, Portugal, 2016.
  6. BURKE, Anthony; Marques, Carolina Silva; Bacalhau, Patrícia; San Juan, Amor A.; A. Teresa Caldeira; Martins Rosário Maria; Fernandes Luis M; Goth, Albertino. "Developing New Small-Molecule Cholinesterase Inhibitors: Harnessing the Power of 3-Substituted-3-Hydroxyoxindoles". Paper presented in World Preclinical Congress, Mastering medicinal chemistry, 14-15 Nov. 2016, Lisbon., 2016.
  7. Bacalhau, Patrícia. "Inhibition Study of MAO-B Activity: Comparing Two Different Techniques". 2015.
  8. Bacalhau, Patrícia. "Oxindole Derivatives as Cholinesterase Inhibitors for Alzheimer’s Disease". 2015.
  9. Bacalhau, Patrícia. "Synthesis and Structure-Activity Relationship Study of Indolinone Analogues". 2015.
  10. Bacalhau, Patrícia. "From a-Glucosidases to Cholinesterases Inhibition via QSAR and Docking Studies". 2015.
  11. Bacalhau, Patrícia. "The role of Cholinesterases in Alzheimer’s Disease: Screening of Target Compounds". 2015.
  12. BURKE, Anthony; Bacalhau, Patrícia; Caldeira Ana Teresa; Martins Rosário Maria. "Inhibition study of MAO-B activity: comparing two diferente techniques". Paper presented in MicroBiotec, 2015.
    10.14733/cadconfp.2015.346-348
  13. Bacalhau, Patrícia. "The Role of Acetylcholinesterase in Alzheimer’s Disease: Enzymatic inhibition studies". 2014.
  14. Bacalhau, Patrícia. "New Chiral Analogues for Neurodegenerative Diseases: The power of metal catalysis". 2014.
Journal article
  1. Bacalhau, Patrícia. "Biocatalysis in Drug Development of Neurodegenerative diseases: a mini review". PharmaHorizon (2020):
    In press
  2. Patrícia Bacalhau; Luís Fernandes; M. Rosário Martins; Fátima Candeias; Elisabete P. Carreiro; Óscar López; A. Teresa Caldeira; et al. "In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor". Bioorganic & Medicinal Chemistry 27 2 (2019): 354-363. https://doi.org/10.1016/j.bmc.2018.12.007.
    10.1016/j.bmc.2018.12.007
  3. Bacalhau, P.; San Juan, A.A.; Marques, C.S.; Peixoto, D.; Goth, A.; Guarda, C.; Silva, M.; et al. "New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives". Bioorganic Chemistry 67 (2016): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988982023&partnerID=MN8TOARS.
    10.1016/j.bioorg.2016.05.004
  4. Bacalhau, P.; San Juan, A.A.; Goth, A.; Caldeira, A.T.; Martins, R.; Burke, A.J.. "Insights into (S)-rivastigmine inhibition of butyrylcholinesterase (BuChE): Molecular docking and saturation transfer difference NMR (STD-NMR)". Bioorganic Chemistry 67 (2016): 105-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974710152&partnerID=MN8TOARS.
    10.1016/j.bioorg.2016.06.002
  5. Totobenazara, J.; Bacalhau, P.; Juan, A.A.S.; Marques, C.S.; Fernandes, L.; Goth, A.; Caldeira, A.T.; Martins, R.; Burke, A.J.. "Design, Synthesis and Bioassays of 3-Substituted-3-Hydroxyoxindoles for Cholinesterase Inhibition". ChemistrySelect 1 13 (2016): 3580-3588. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996450731&partnerID=MN8TOARS.
    10.1002/slct.201600932
  6. Viana, H.; Carreiro, E.P.; Goth, A.; Bacalhau, P.; Caldeira, A.T.; Do Rosário Martins, M.; Burke, A.J.. "Sequential alcohol oxidation/putative homo Claisen-Tishchenko-type reaction to give esters: A key process in accessing novel biologically active lactone macrocycles". RSC Advances 6 68 (2016): 63214-63223. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978127703&partnerID=MN8TOARS.
    10.1039/c6ra07547a
  7. Bacalhau, Patrícia. "Mechanisms, Clinical Strategies, and Promising Treatments of Neurodegenerative Diseases". Neurodegenerative Diseases 15 1 (2015): 1-1969. http://dx.doi.org/10.1159/000381736.
    10.1159/000381736
Thesis / Dissertation
  1. Bacalhau, Patrícia. "Biochemical mechanisms and target drugs in neurodegenerative diseases". PhD, 2018.
  2. Bacalhau, Patricia Alexandra Anico Gazimba. "Relatório da prática de ensino supervisionada na área da especialização do Mestrado em ensino de Física e Qímica, na escola secundária/3 Rainha Santa Isabel". Master, 2011. http://hdl.handle.net/10174/15414.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018 Doença de Alzheimer: um olhar sobre mecanismos bioquímicos e alvos terapêuticos Jornadas do Departamento de Química 2018
(Évora, Portugal)
2017 a-glucosidases and cholinesterases inhibitors XXV ENSPQ
(Lisbon)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2015 - 2016 Mecanismos de Ação Enzimática de Potenciais Fármacos para a Doença de Parkinson
Co-supervisor
 Biotechnology (Degree)
Universidade de Évora Departamento de Química, Portugal
2015 - 2016 Mecanismos de ação enzimática de Acetilcolinesterase, Butirilcolinesterase e potenciais fármacos para doenças neurodegenerativa .
Co-supervisor
Universidade de Évora Departamento de Química, Portugal
2014 - 2015 Mecanismos de ação enzimática de monoamina oxidase e potenciais fármacos para doenças neurodegenerativas
Co-supervisor
Universidade de Évora Departamento de Química, Portugal
2013 - 2014 Cinética enzimática: o papel da acetilcolinesterase na Doença de Alzheimer
Co-supervisor
Universidade de Évora Departamento de Química, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/10/29 - 2024/10/30 Member of the organizing committee V Congresso Ibérico da Dehesa e do Montado : “Resiliência e rentabilidade: modelos de negócio num sistema de incerteza” (29-30 Outubro de 2024) (2024/10/29 - 2024/10/30)
Congress (Co-organisor)
 Instituto Mediterrâneo para a Agricultura Ambiente e Desenvolvimento, Portugal

Universidade de Évora, Portugal
2024/10/28 - 2024/10/28 Member of the organizing committee Workshop “Missão Solo-Projetos, Sinergias e Impactos” (28 de Outubro de 2024) (2024/10/28 - 2024/10/28)
Workshop (Co-organisor)
 Instituto Mediterrâneo para a Agricultura Ambiente e Desenvolvimento, Portugal

Universidade de Évora, Portugal
2023/10/24 - 2023/10/27 Member of the organizing committee of IUFRO Forest Environment Div 8 Conference 2023 - FORESTED LANDSCAPES in the Post-2020 Global Biodiversity Framework: mitigation options towards implementation of the SDGs (24-27 Outubro, Évora, Portugal) (2023/10/24 - 2023/10/27)
Congress (Co-organisor)
 Instituto Mediterrâneo para a Agricultura Ambiente e Desenvolvimento, Portugal

Universidade de Évora, Portugal
2022/10/26 - 2022/10/28 Member of the organizing committee of XIII Seminário International da rede FONCIMED: “Agricultural uses of water and intensification of production systems: what impacts on land resources?” (26-28 Outubro, Evora, Portugal) (2022/10/26 - 2022/10/28)
Conference (Co-organisor)
 Instituto Mediterrâneo para a Agricultura Ambiente e Desenvolvimento, Portugal

Universidade de Évora, Portugal
2017/09/05 - 2017/09/08 The International Symposium on Synthesis and Catalysis 2017 (ISySyCat2017) focus on key topics in contemporary organic and organometallic synthesis and catalysis, which are of relevance to both academic and industrial chemists alike. (2017/09/05 - 2017/09/08)
Conference (Member of the Organising Committee)
 Universidade de Évora Centro de Química de Évora, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2009 - 2009 The power of DNA technologies
Workshop
European Molecular Biology Laboratory, Germany
2006 - 2006 Secondary School Science Education
Workshop
European Molecular Biology Laboratory, Germany
2003 - 2003 Biology since the Doublex Helix
Workshop
European Molecular Biology Laboratory, Germany

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024 - Current Curricular Unit: Human Biochemistry Ciências Farmacêuticas (Mestrado integrado) Universidade de Évora Escola de Saúde e Desenvolvimento Humano, Portugal
2024 - Current Curricular unit: Biochemistry Bioquímica (Licenciatura) Universidade de Évora Escola de Ciências e Tecnologia, Portugal
2023 - Current Curricular Unit: General Biochemistry Biologia (Licenciatura) Universidade de Évora Escola de Ciências e Tecnologia, Portugal
2002 - 2022 Physics and Chemistry Teacher (Ensino secundário)