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Patrícia Bacalhau has a background in supramolecular chemistry and biochemical mechanisms of neurodegenerative diseases, holds a degree in Biochemistry from the University of Algarve (Portugal), an MSc degree in Chemistry Teaching and a Ph.D. in Biochemistry from the University of Évora. Her training in molecular synthesis started in 1999 as a student at ITQB, where Patrícia developed lanthanide coordinated crown azamacrocycles (radiolabelled with 153Sm) for therapeutic use in bone cancer (Portugal). During her Ph.D research , Patrícia engaged the study of the biochemical mechanisms involved in Alzheimer’s and Parkinson’s diseases. Her main results involved the discovery of a lead compound with therapeutic benefits for AD. Her Ph.D. was successfully completed in 4 years (2013-2017) and her public defense took place last January. During this time, Patrícia published several peer reviewed papers, a patent and her investigation also produced numerous presentations in international congresses. Currently, Patrícia is preparing two manuscripts with focus on BACE-1. For the past 15 years, Patrícia has been a Physics and Chemistry high school teacher.
Identification

Personal identification

Full name
Patrícia Alexandra Anico Gazimba Bacalhau

Citation names

  • Bacalhau, Patrícia
  • Bacalhau, P.

Author identifiers

Ciência ID
9413-39DE-C1AF
ORCID iD
0000-0002-4769-7437

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2018/01/30
Concluded
PhD in Biochemistry (Doutoramento)
Universidade de Évora Instituto de Investigação e Formação Avançada, Portugal
"Biochemical mechanisms and target drugs in neurodegenerative diseases" (THESIS/DISSERTATION)
Aprovado com distinção e louvor
2011
Concluded
Teaching Physics and Chemistry in High School (Mestrado)
Universidade de Évora, Portugal
"Prática de Ensino Supervisionada na área da especialização do Mestrado em Ensino de Física e Química" (THESIS/DISSERTATION)
16
2005
Concluded
Legal medicine and forensic sciences (Pós-Graduação)
Universidade de Lisboa Faculdade de Medicina, Portugal
13
2001
Concluded
Biochemistry (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Macrocycles and its aplications to medicine: Synthesis and study of some of its complexes" (THESIS/DISSERTATION)
13
Affiliation

Science

2014 - 2015 Contracted Researcher (Research)
Universidade de Évora Centro de Química de Évora, Portugal

Others

2018/01/31 - Current Research Colaborator
Universidade de Évora Centro de Química de Évora, Portugal
2017/09/01 - 2019/08/31 Physics and chemistry teacher (7º, 8º and 9º grades). Agrupamento de Escolas de Mourão
Ministério da Educação, Portugal
2017/01/01 - 2017/08/31 Physics and chemistry teacher (8º and 9º grades). Escola Secundária/3 da Rainha Santa Isabel, Estremoz
Ministério da Educação, Portugal
2016/11/01 - 2016/12/07 Physics and chemistry teacher (7º and 8º grades). Agrupamento de Escolas José Régio
Ministério da Educação, Portugal
2011/09/01 - 2012/08/31 Physics and chemistry teacher (7º and 8º grades and 1st year of enology course). Escola Secundária/3 Rainha Santa Isabel, Estremoz
Ministério da Educação, Portugal
2010/09/01 - 2011/08/31 Physics and chemistry teacher (7º, 9º and 11º grades). Escola Secundária/3 Rainha Santa Isabel, Estremoz
Ministério da Educação, Portugal
2009/09/24 - 2010/08/31 Physics and chemistry teacher (10º and 11º grades and 2nd year of enology course). Escola Secundária/3 Rainha Santa Isabel, Estremoz
Ministério da Educação, Portugal
2010/01/29 - 2010/03/17 Physics and chemistry teacher (10º and 11º grades). Escola Básica 2,3/S Dr. Hernâni Cidade, Redondo
Ministério da Educação, Portugal
2009/10/01 - 2009/12/15 Science teacher. Escola Básica 2,3/Secundária Cunha Rivara, Arraiolos
Ministério da Educação, Portugal
2008/10/01 - 2009/06/10 Science teacher. Escola Básica 2,3/Secundária Cunha Rivara, Arraiolos
Ministério da Educação, Portugal
2007/10/01 - 2008/06/10 Science teacher. Escola Básica 2,3/Secundária Cunha Rivara, Arraiolos
Ministério da Educação, Portugal
2004/05/03 - 2004/08/31 Physics and chemistry teacher (7º, 8º and 9º grades). Escola Básica 2,3 da Bobadela, Loures
Ministério da Educação, Portugal
2002/09/26 - 2003/08/31 Physics and chemistry (7º,8º and 9º grades). Escola Básica Integrada de Mourão
Ministério da Educação, Portugal
2001/09/15 - 2002/08/31 Technician responsible for the dissemination and implementation of generic medicines at the level of health centers in mainland Portugal.
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
Outputs

Publications

Conference abstract
  1. Bacalhau, Patrícia. "Computational studies with oxindole frameworks". 2018.
    Published
  2. Bacalhau, Patrícia. "Synthesis of a-glucosidases and cholinesterases inhibitors". 2017.
    Published
  3. Bacalhau, Patrícia; Fernandes, Luís; Burke, A.J.. "From a-glucosidases to cholinesterases inhibition - Synthesis, SAR, STD-NMR". Paper presented in XXII Encontro Luso-Galego de Química, 2016.
  4. Bacalhau, Patrícia. "Inhibition Study of MAO-B Activity: Comparing Two Different Techniques". Paper presented in Microbiotec, 2015.
    Published
  5. Bacalhau, Patrícia. "Oxindole Derivatives as Cholinesterase Inhibitors for Alzheimer’s Disease". Paper presented in Microbiotec, 2015.
    Published
  6. Bacalhau, Patrícia. "Targetting Cholinesterases for the Treatment of Alzheimer’s Disease: Synthesis and Structure-Activity Relationship Study of Indolinone Analogues". Paper presented in SPJ-OCS, 2015.
    Published
  7. Bacalhau, Patrícia. "From a-Glucosidases to Cholinesterases Inhibition via QSAR and Docking Studies". Paper presented in SPJ-OCS, 2015.
    Published
  8. Bacalhau, Patrícia. "The role of Cholinesterases in Alzheimer’s Disease: Screening of Target Compounds". 2015.
    Published
  9. Bacalhau, Patrícia. "The Role of Acetylcholinesterase in Alzheimer’s Disease: Enzymatic inhibition studies". Paper presented in Congress of the Portuguese Biochemical Society, 2014.
    Published
  10. Bacalhau, Patrícia. "New Chiral Analogues for Neurodegenerative Diseases: The power of metal catalysis". Paper presented in International Symposium on Medicinal Chemistry, 2014.
    Published
Conference poster
  1. Bacalhau, Patrícia. "Computational studies with oxindole frameworks". 2018.
  2. Bacalhau, Patrícia. "Synthesis of a-glucosidases and cholinesterases inhibitors". Paper presented in ISYSYCAT 2017, 2017.
  3. Bacalhau, Patrícia. "From a-glucosidases to cholinesterases inhibition - Synthesis, SAR, STD-NMR". 2016.
  4. Bacalhau, Patrícia. "Inhibition Study of MAO-B Activity: Comparing Two Different Techniques". 2015.
  5. Bacalhau, Patrícia. "Oxindole Derivatives as Cholinesterase Inhibitors for Alzheimer’s Disease". 2015.
  6. Bacalhau, Patrícia. "Synthesis and Structure-Activity Relationship Study of Indolinone Analogues". 2015.
  7. Bacalhau, Patrícia. "From a-Glucosidases to Cholinesterases Inhibition via QSAR and Docking Studies". 2015.
  8. Bacalhau, Patrícia. "The role of Cholinesterases in Alzheimer’s Disease: Screening of Target Compounds". 2015.
  9. Bacalhau, Patrícia. "The Role of Acetylcholinesterase in Alzheimer’s Disease: Enzymatic inhibition studies". 2014.
  10. Bacalhau, Patrícia. "New Chiral Analogues for Neurodegenerative Diseases: The power of metal catalysis". 2014.
Journal article
  1. Bacalhau, Patrícia. "Biocatalysis in Drug Development of Neurodegenerative diseases: a mini review". PharmaHorizon (2020):
    In press
  2. Patrícia Bacalhau; Luís Fernandes; M. Rosário Martins; Fátima Candeias; Elisabete P. Carreiro; Óscar López; A. Teresa Caldeira; et al. "In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor". Bioorganic & Medicinal Chemistry 27 2 (2019): 354-363. https://doi.org/10.1016/j.bmc.2018.12.007.
    10.1016/j.bmc.2018.12.007
  3. Bacalhau, P.; San Juan, A.A.; Marques, C.S.; Peixoto, D.; Goth, A.; Guarda, C.; Silva, M.; et al. "New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives". Bioorganic Chemistry 67 (2016): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988982023&partnerID=MN8TOARS.
    10.1016/j.bioorg.2016.05.004
  4. Bacalhau, P.; San Juan, A.A.; Goth, A.; Caldeira, A.T.; Martins, R.; Burke, A.J.. "Insights into (S)-rivastigmine inhibition of butyrylcholinesterase (BuChE): Molecular docking and saturation transfer difference NMR (STD-NMR)". Bioorganic Chemistry 67 (2016): 105-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974710152&partnerID=MN8TOARS.
    10.1016/j.bioorg.2016.06.002
  5. Totobenazara, J.; Bacalhau, P.; Juan, A.A.S.; Marques, C.S.; Fernandes, L.; Goth, A.; Caldeira, A.T.; Martins, R.; Burke, A.J.. "Design, Synthesis and Bioassays of 3-Substituted-3-Hydroxyoxindoles for Cholinesterase Inhibition". ChemistrySelect 1 13 (2016): 3580-3588. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996450731&partnerID=MN8TOARS.
    10.1002/slct.201600932
  6. Viana, H.; Carreiro, E.P.; Goth, A.; Bacalhau, P.; Caldeira, A.T.; Do Rosário Martins, M.; Burke, A.J.. "Sequential alcohol oxidation/putative homo Claisen-Tishchenko-type reaction to give esters: A key process in accessing novel biologically active lactone macrocycles". RSC Advances 6 68 (2016): 63214-63223. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978127703&partnerID=MN8TOARS.
    10.1039/c6ra07547a
  7. Bacalhau, Patrícia. "Mechanisms, Clinical Strategies, and Promising Treatments of Neurodegenerative Diseases". Neurodegenerative Diseases 15 1 (2015): 1-1969. http://dx.doi.org/10.1159/000381736.
    10.1159/000381736
Thesis / Dissertation
  1. Bacalhau, Patrícia. "Biochemical mechanisms and target drugs in neurodegenerative diseases". PhD, 2018.
  2. Bacalhau, Patricia Alexandra Anico Gazimba. "Relatório da prática de ensino supervisionada na área da especialização do Mestrado em ensino de Física e Qímica, na escola secundária/3 Rainha Santa Isabel". Master, 2011. http://hdl.handle.net/10174/15414.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018 Doença de Alzheimer: um olhar sobre mecanismos bioquímicos e alvos terapêuticos Jornadas do Departamento de Química 2018
(Évora, Portugal)
2017 a-glucosidases and cholinesterases inhibitors XXV ENSPQ
(Lisbon)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2015 - 2016 Mecanismos de Ação Enzimática de Potenciais Fármacos para a Doença de Parkinson
Co-supervisor
Biotechnology (Degree)
Universidade de Évora Departamento de Química, Portugal
2015 - 2016 Mecanismos de ação enzimática de Acetilcolinesterase, Butirilcolinesterase e potenciais fármacos para doenças neurodegenerativa .
Co-supervisor
Universidade de Évora Departamento de Química, Portugal
2014 - 2015 Mecanismos de ação enzimática de monoamina oxidase e potenciais fármacos para doenças neurodegenerativas
Co-supervisor
Universidade de Évora Departamento de Química, Portugal
2013 - 2014 Cinética enzimática: o papel da acetilcolinesterase na Doença de Alzheimer
Co-supervisor
Universidade de Évora Departamento de Química, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2017/09/05 - 2017/09/08 The International Symposium on Synthesis and Catalysis 2017 (ISySyCat2017) focus on key topics in contemporary organic and organometallic synthesis and catalysis, which are of relevance to both academic and industrial chemists alike. (2017/09/05 - 2017/09/08)
Conference (Member of the Organising Committee)
Universidade de Évora Centro de Química de Évora, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2009 - 2009 The power of DNA technologies
Workshop
European Molecular Biology Laboratory, Germany
2006 - 2006 Secondary School Science Education
Workshop
European Molecular Biology Laboratory, Germany
2003 - 2003 Biology since the Doublex Helix
Workshop
European Molecular Biology Laboratory, Germany