???global.info.a_carregar???
Luís G Gonçalves has a degree in Biochemistry from the Faculty of Sciences of the University of Lisbon (1999). In 2008, he completed his PhD in Biochemistry at ITQB NOVA. Currently, Luís is a PhD Researcher Hired at Proteomics of Non-Model Organisms laboratory, ITQB NOVA. He has published 40 articles in specialized journals, 3 book chapters; and 2 patents. Since 2019, Luís is a professor of the Bioanalytical Processes curricular unit of the master’s degree in Biochemistry for Health at Nova University He is responsible for metabolomics classes in several master’s programs and in the doctoral program MOLBioS at ITQB NOVA. Currently Luís the supervisor of a PhD student and co-supervisor of 2. He also supervised 6 master students, and diverse students internships. Luis is extremely engaged in outreach activities with the visit to different schools and participation on science festivals. Luís G Gonçalves' scientific career is diversified, with experience in several fields, with a special focus on the application of Nuclear Magnetic Resonance to study of cellular metabolism. Luís is specialist in metabolomics, having experience with different models, from microorganisms to biofluids, passing through cell cultures. One of Luis focus is cancer metabolism, where he has been responsible for studies dedicated to the metabolomics of patient samples, namely tumors, cerebral spinal fluid, ascitic fluid and peripheral blood serum. Furthermore, he has also explored the in vitro and in vivo metabolic adaptation in the context of various oncological diseases, such as hematological diseases, glioblastoma and ovarian, cervical, breast and lung carcinomas. L
Read full resume ↓
Identification

Personal identification

Full name
Luís Pedro Gafeira Gonçalves

Citation names

  • Gonçalves, Luís G

Author identifiers

Ciência ID
9411-599F-7B36
ORCID iD
0000-0001-5683-3552

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Medical and Health Sciences - Basic Medicine
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2008/01/28
Concluded
 Bioquímica (Doutoramento)
Major in Especialidade: Bioquímica
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Osmo- and Thermo-adaptation in Hyperthermophilic Archaea: Identification of Compatible Solutes, Accumulation Profiles, and Biosynthetic Routes in Archaeoglobus Spp" (THESIS/DISSERTATION)
1999
Concluded
 Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Biochemistry" (THESIS/DISSERTATION)
 15/20
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - Current Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/01/01 - 2018/12/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/02/01 - 2017/12/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008/02/01 - 2015/01/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projects

Grant

Designation Funders
2022/05/17 - 2023/05/15 Luís G Gonçalves
SymbNET PhD Project Award
SymbNET PhD Project Award
Supervisor
European Union
Concluded
2017/01/01 - 2020/12/31 An OMICS Network to Prevent and Control Infectious Diseases and Antimicrobial Resistance (ONEIDA)
SAICTPAC/0015/2015
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Concluded
2016/02/01 - 2018/12/31 Carboxydotrophs for alkane production: from CO/CO2 to fuel
SFRH/BPD/111100/2015
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/02/01 - 2014/01/31 UNIQUE OSMOLYTES IN THE HYPERTHERMOPHILIC ARCHAEON ARCHAEOGLOBUS FULGIDUS: BIOSYNTHESIS, REGULATION AND THEIR SPECIALIZED ROLE IN STRESS RESPONSE
SFRH/BPD/26905/2006
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/05 - 2012/04 Understanding how hyperthermophilic microorganisms cope with heat stress: the role of unique polyolphosphodiester compounds
71146
Provided by PTCRIS: 71146
 Fundação para a Ciência e a Tecnologia, I.P.
2001/10/01 - 2005/09/30 ESTRATÉGIAS DE ADAPTAÇÃO A TEMPERATURA E SALINIDADE ELEVADAS EM ORGANISMOS HIPERTERMÓFILOS PERTENCENTES AO GÉNERO ARCHAEGLOBUS
SFRH/BD/5076/2001
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

BioResources 4 Sustainability, Portugal

Universidade NOVA de Lisboa, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/08/01 - 2022/01/31 Exploring unique metabolic traits of biotechnological interest in fructophilic yeasts
PTDC/BIA-MIC/29529/2017
Universidade NOVA de Lisboa, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/01/01 - 2020/12/31 ONEIDA: An Omics Network to Prevent and Control Infectious Diseases and Antimicrobial Resistance.
SAICTPAC/0015/2015
LISBOA-01-0145-FEDER-016417
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Molecular, Structural and Cellular Microbiology
UID/CBQ/04612/2019
Universidade NOVA de Lisboa, Portugal

Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/07/01 - 2016/06/30 NMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics
RECI/BBB-BQB/0230/2012
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2015/10/31 Structural investigation of the anti-tuberculosis drug target phosphatidylinositol phosphate synthase (PIPS)
PTDC/BBB-BEP/2532/2012
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/05 - 2015/04 Cerebrospinal fluid metabolome: an instructive niche for CNS metastasis
PTDC/BIM-ONC/1242/2012
126225
Provided by PTCRIS: 126225
PTDC/BIM-ONC/1242/2012
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/06/01 - 2014/11/30 Reverting the carbon cycle: from CO2 to biodiesel
EXPL/BIA-MIC/1455/2012
EXPL/BIA-MIC/1455/2012
Principal investigator
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 4 - 2011-2012
PEst-OE/EQB/LA0004/2011
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/05/05 - 2012/04/30 Estudo dos mecanismos de adaptação a stress térmico em microorganismos hipertermófilos: função fisiológica de poliolfosfodiésteres
PTDC/BIA-MIC/71146/2006
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Gonçalves, Luís G. "Exploring Cancer Metabolism: Applications of Metabolomics and Metabolic Phenotyping in Cancer Research and Diagnostics". 2020.
    10.1007/978-3-030-34025-4_19
  2. Luis G Goncalves; Nuno Borges; Helena Santos. "Organic compatible solutes of prokaryotes that thrive in hot environments: the importance of ionic compounds for thermostabilization". edited by Unknown Unknown, 497-520. Springer Japan, 2011.
Conference paper
  1. Sousa, Joana; Gonçalves, Luís G; Silva, Fernanda. "Metabolomic profile of biological fluids of ovarian cancer patients". Paper presented in EACR-AACR-SIC 2015, Firenze, 2015.
Conference poster
  1. Costa, Vanessa G; Simões, Miguel A.; Haddad, Nabila; Gonçalves, Luís G; V Coelho, Ana; Arraiano, Cecília M.; Matos, Rute G; et al. "Exploring the role of PNPase in the foodborne pathogen Campylobacter jejuni". Paper presented in "The 48th FEBS Congress" Milano, Italy, 2024.
  2. Gonçalves, Luís G; Morais, Elisabete ); Susana Santos; Jean, Armengaud; Miragaia, Maria; Ana Varela Coelho. "Glycine betaine role in Staphylococcus epidermidis pH adaptation and pathogenicity". Paper presented in Microbiotec 2023, 2023.
  3. Gaifem, Joana; Araújo, Andreia; Belinha, Ana; Mesquita, Inês; Gonçalves, Luís; Santos, Sophia; Torrado, Egídio; et al. "Immunometabolic characterization of the intestinal mucosa upon chemically-induced colitis in mice from different animal facilities". Paper presented in Summer Frontiers 2016 – Systems Biology of Innate Immunity, 2016.
Journal article
  1. Filipa Martins; Renata Arada; Hélio Barros; Paulo Matos; José Ramalho; Valentín Ceña; Vasco D. B. Bonifácio; Luís G. Gonçalves; Jacinta Serpa. "Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM)". Cancer Gene Therapy (2025): https://doi.org/10.1038/s41417-025-00906-8.
    10.1038/s41417-025-00906-8
  2. Isabel Lemos; Catarina Freitas-Dias; Ana Hipólito; José Ramalho; Fabrizio Carteni; Luís G. Gonçalves; Stefano Mazzoleni; Jacinta Serpa. "Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling in the ES-2 Ovarian Carcinoma Cell Line, Influencing Cell Proliferation, Quiescence, and Chemoresistance in a Cell-of-Origin-Specific Manner". Metabolites (2025): https://doi.org/10.3390/metabo15040244.
    10.3390/metabo15040244
  3. Isabel Lemos; Catarina Freitas-Dias; Ana Hipólito; José Ramalho; Fabrizio Carteni; Luís G. Gonçalves; Stefano Mazzoleni; Jacinta Serpa. "Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling, Sustaining Proliferation, Quiescence, and Migration in MDA-MB-231, a Triple-Negative Breast Carcinoma (TNBC) Cell Line". Metabolites (2025): https://doi.org/10.3390/metabo15040227.
    10.3390/metabo15040227
  4. Fabio Giovannercole; Luís Gafeira Gonçalves; Jean Armengaud; Ana Coelho; Alex Khomutov; Daniela De Biase. "Integrated multi-omics unveil the impact of H-phosphinic analogs of glutamate and a-ketoglutarate on Escherichia coli metabolism". Journal of Biological Chemistry (2024): http://dx.doi.org/10.1016/j.jbc.2024.107803.
    10.1016/j.jbc.2024.107803
  5. Cindy Mendes; Isabel Lemos; Ana Hipólito; Bruna Abreu; Catarina Freitas-Dias; Filipa Martins; Rita F. Pires; et al. "Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells". Bioscience Reports 44 7 (2024): https://novaresearch.unl.pt/en/publications/33f4d8d7-4fa0-4d8a-8fbb-bf85a2034955.
    10.1042/BSR20240752
  6. Dragana P. C. de Barros; Luís P. Fonseca; Luís G. Gonçalves; Diogo S. Serrano; Abel Oliva. "Design and Biocompatibility of Biodegradable Poly(octamethylene suberate) Nanoparticles to Treat Skin Diseases". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16060753.
    10.3390/pharmaceutics16060753
  7. Filipa Martins; Céline Gonçalves; Fernanda Silva; David van der Kellen; Eduarda Martins; Marta Pojo; Luís Gonçalves; Bruno Costa; Jacinta Serpa. "Abstract 1770 Targeting glutamine availability with glutaminase 1-based glioblastoma therapy". Journal of Biological Chemistry (2024): http://dx.doi.org/10.1016/j.jbc.2024.106461.
    10.1016/j.jbc.2024.106461
  8. Cindy Mendes; Isabel Lemos; Sara Granja; Fátima Baltazar; Luís Gonçalves; Vasco D. Bonifácio; Jacinta Serpa. "Abstract 1779 EGF-promoted metabolic and gene expression remodeling opens metabolism-based therapeutic opportunities in NSCLC". Journal of Biological Chemistry (2024): http://dx.doi.org/10.1016/j.jbc.2024.106462.
    10.1016/j.jbc.2024.106462
  9. Catarina Freitas-Dias; Filipe Gonçalves; Filipa Martins; Isabel Lemos; Luís G. Gonçalves; Jacinta Serpa. "Interaction between NSCLC Cells, CD8+ T-Cells and Immune Checkpoint Inhibitors Potentiates Coagulation and Promotes Metabolic Remodeling—New Cues on CAT-VTE". Cells (2024): https://doi.org/10.3390/cells13040305.
    10.3390/cells13040305
  10. Ana Hipólito; Renato Xavier; Cheila Brito; Ana Tomás; Isabel Lemos; Luís C. Cabaço; fernanda silva; et al. "BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma". Biochimica et biophysica acta. Molecular basis of disease 1870 2 (2024): https://novaresearch.unl.pt/en/publications/840b30bb-52c6-42da-96cc-1c144261dd44.
    10.1016/j.bbadis.2023.166983
  11. Ana Hipólito; Cindy Mendes; Filipa Martins; Isabel Lemos; Inês Francisco; Fernando Cunha; Teresa Almodôvar; et al. "H2S-Synthesizing Enzymes Are Putative Determinants in Lung Cancer Management toward Personalized Medicine". Antioxidants (2023): https://doi.org/10.3390/antiox13010051.
    10.3390/antiox13010051
  12. Sofia C. Nunes; Joana Sousa; Fernanda Silva; Margarida Silveira; António Guimarães; Jacinta Serpa; Ana Félix; Luís G. Gonçalves. "Peripheral Blood Serum NMR Metabolomics Is a Powerful Tool to Discriminate Benign and Malignant Ovarian Tumors". Metabolites (2023): https://doi.org/10.3390/metabo13090989.
    10.3390/metabo13090989
  13. Cindy Mendes; Isabel Lemos; Inês Francisco; Teresa Almodôvar; Fernando Cunha; Cristina Albuquerque; Luis G Goncalves; Jacinta Serpa. "NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF stimuli in EGFR-mutated NSCLC". Lung Cancer 182 (2023): https://novaresearch.unl.pt/en/publications/e2577263-906d-4c54-8bb1-e6fecaec8ac8.
    10.1016/j.lungcan.2023.107283
  14. Filipa Martins; David van der Kellen; Luís G. Gonçalves; Jacinta Serpa. "Metabolic Profiles Point Out Metabolic Pathways Pivotal in Two Glioblastoma (GBM) Cell Lines, U251 and U-87MG". Biomedicines (2023): https://doi.org/10.3390/biomedicines11072041.
    10.3390/biomedicines11072041
  15. Rita Rosado-Ramos; Gonçalo Manuel Poças; Daniela Marques; Alexandre Foito; David M Sevillano; Mafalda Lopes-da-Silva; Luis G Goncalves; et al. "Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage". Nature Communications 14 1 (2023): 1918-1918. https://novaresearch.unl.pt/en/publications/49c31a60-a665-4b18-bca4-8b339744208f.
    10.1038/s41467-023-37561-2
  16. Ana Fernandes; Luís Gafeira Gonçalves; Maria Bento; Sandra Anjo; Bruno Manadas; Clara Barroso; Miguel Villar; et al. "Mass Spectrometry-Based Proteomic and Metabolomic Profiling of Serum Samples for Discovery and Validation of Tuberculosis Diagnostic Biomarker Signature". International Journal of Molecular Sciences 23 22 (2022): 13733-13733. http://dx.doi.org/10.3390/ijms232213733.
    10.3390/ijms232213733
  17. Luis Gafeira Gonçalves; Susana Santos; Laidson Paes Gomes; Jean Armengaud; Maria Miragaia; Ana Varela Coelho. "Skin-to-blood pH shift triggers metabolome and proteome global remodelling in Staphylococcus epidermidis". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.1000737.
    10.3389/fmicb.2022.1000737
  18. Filipa Lopes-Coelho; Filipa Martins; Ana Hipólito; Silvia V Conde; Pereira SA; Luis G Goncalves; Jacinta Serpa. "A Metabolic Signature to Monitor Endothelial Cell Differentiation, Activation, and Vascular Organization". Biomedicines 10 9 (2022): https://novaresearch.unl.pt/en/publications/50e26994-58cf-4611-9007-88b762293d35.
    10.3390/biomedicines10092293
  19. Romano, Giovanna; Almeida, Mariana; Varela Coelho, Ana; Cutignano, Adele; Gonçalves, Luís G; Hansen, Espen; Khnykin, Denis; et al. "Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications". Marine Drugs 20 4 (2022): 219. http://dx.doi.org/10.3390/md20040219.
    10.3390/md20040219
  20. Apura, Patrícia; Gonçalves, Luís G; Viegas, Sandra C.; Arraiano, C.M.. Corresponding author: Arraiano, C.M.. "The world of ribonucleases from pseudomonads: a short trip through the main features and singularities". Microbial Biotechnology (2021): http://dx.doi.org/10.1111/1751-7915.13890.
    10.1111/1751-7915.13890
  21. Nunes, Sofia C.; Ramos, Cristiano; Santos, Inês; Mendes, Cindy; Silva, Fernanda; Vicente, João B.; Pereira, Sofia A.; et al. "Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.722412.
    10.3389/fcell.2021.722412
  22. Gonçalves, Luís G; Conde, Ricardo; Laires, Rita; Rizvi, A; Barroso, R; Villar, M; Macedo, Rita; et al. Corresponding author: Coelho, A. V.. "Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort". Biomedical Journal (2021): http://dx.doi.org/10.1016/j.bj.2021.07.006.
    10.1016/j.bj.2021.07.006
  23. Martins, Filipa; Gonçalves, Luís G; Pojo, Marta; Serpa, Jacinta. "Take Advantage of Glutamine Anaplerosis, the Kernel of the Metabolic Rewiring in Malignant Gliomas.". Biomolecules 10 10 (2020): 1370. https://europepmc.org/articles/PMC7599606.
    Open access • 10.3390/biom10101370
  24. Mesquita, Inês; Ferreira, Carolina; Moreira, Diana; Kluck, George Eduardo Gabriel; Barbosa, Ana Margarida; Torrado, Egídio; Dinis-Oliveira, Ricardo Jorge; et al. "The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis". Cell Reports 30 12 (2020): 4052-4064.e7. http://dx.doi.org/10.1016/j.celrep.2020.02.098.
    10.1016/j.celrep.2020.02.098
  25. Graça-lopes, G.; Graça, G.; Barahona, S.; Moreira, R.N.; Arraiano, C.M.; Gonçalves, L.G.. "NMR-metabolomics shows that bola is an important modulator of Salmonella typhimurium metabolic processes under virulence conditions". Metabolites 9 11 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074230813&partnerID=MN8TOARS.
    10.3390/metabo9110243
  26. Gonçalves, C.; Ferreira, C.; Gonçalves, L.G.; Turner, D.L.; Leandro, M.J.; Salema-Oom, M.; Santos, H.; Gonçalves, P.. "A New Pathway for Mannitol Metabolism in Yeasts Suggests a Link to the Evolution of Alcoholic Fermentation". Frontiers in Microbiology 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075257813&partnerID=MN8TOARS.
    10.3389/fmicb.2019.02510
  27. Pastor, J.M.; Borges, N.; Pagán, J.P.; Castanõ-Cerezo, S.; Csonka, L.N.; Goodner, B.W.; Reynolds, K.A.; et al. "Fructose metabolism in Chromohalobacter salexigens: Interplay between the Embden-Meyerhof-Parnas and Entner-Doudoroff pathways". Microbial Cell Factories 18 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070780479&partnerID=MN8TOARS.
    10.1186/s12934-019-1178-x
  28. Martins, R.G.; Gonçalves, L.G.; Cunha, N.; Bugalho, M.J.. "Metabolomic Urine Profile: Searching for New Biomarkers of SDHx-Associated Pheochromocytomas and Paragangliomas". The Journal of clinical endocrinology and metabolism 104 11 (2019): 5467-5477. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072942650&partnerID=MN8TOARS.
    10.1210/jc.2019-01101
  29. Gaifem, Joana; Gonçalves, Luís G.; Dinis-Oliveira, Ricardo J.; Cunha, Cristina; Carvalho, Agostinho; Torrado, Egídio; Rodrigues, Fernando; et al. "L-Threonine Supplementation During Colitis Onset Delays Disease Recovery". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.01247.
    10.3389/fphys.2018.01247
  30. Sandrina Nobrega-Pereira; Francisco Caiado; Tânia Carvalho; Inês Matias; Gonçalo Graça; Luis G Goncalves; Bruno Silva-Santos; Haakan Norell; Sergio Dias. "VEGFR2–mediated reprogramming of mitochondrial metabolism regulates the sensitivity of acute myeloid leukemia to chemotherapy". Cancer Research 78 3 (2018): 731-741. https://novaresearch.unl.pt/en/publications/677da7a3-7234-41b4-a2fa-fbcaa6c99299.
    10.1158/0008-5472.CAN-17-1166
  31. Graça, G.; Desterro, J.; Sousa, J.; Fonseca, C.; Silveira, M.; Serpa, J.; Carvalho, T.; da Silva, M.G.; Gonçalves, L.G.. "Identification of putative biomarkers for leptomeningeal invasion in B-cell non-Hodgkin lymphoma by NMR metabolomics". Metabolomics 13 11 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030842168&partnerID=MN8TOARS.
    10.1007/s11306-017-1269-9
  32. Lopes-Coelho, F.; Nunes, C.; Gouveia-Fernandes, S.; Rosas, R.; Silva, F.; Gameiro, P.; Carvalho, T.; et al. "Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients and a vehicle to kill cancer cells". Oncotarget 8 47 (2017): 82803-82823. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030846809&partnerID=MN8TOARS.
    10.18632/oncotarget.20294
  33. Arts, R.J.W.; Novakovic, B.; ter Horst, R.; Carvalho, A.; Bekkering, S.; Lachmandas, E.; Rodrigues, F.; et al. "Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity". Cell Metabolism 24 6 (2016): 807-819. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003874481&partnerID=MN8TOARS.
    10.1016/j.cmet.2016.10.008
  34. Arts, R.J.W.; Carvalho, A.; La Rocca, C.; Palma, C.; Rodrigues, F.; Silvestre, R.; Kleinnijenhuis, J.; et al. "Immunometabolic Pathways in BCG-Induced Trained Immunity". Cell Reports 17 10 (2016): 2562-2571. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002577534&partnerID=MN8TOARS.
    10.1016/j.celrep.2016.11.011
  35. Silva, L.S.; Goncalves, L.G.; Silva, F.; Domingues, G.; Maximo, V.; Ferreira, J.; Lam, E.W.-F.; et al. "STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment". Tumor Biology 37 4 (2016): 5385-5395. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946854642&partnerID=MN8TOARS.
    10.1007/s13277-015-4385-z
  36. Lopes-Coelho, F.; Gouveia-Fernandes, S.; Gonçalves, L.G.; Nunes, C.; Faustino, I.; Silva, F.; Félix, A.; Pereira, S.A.; Serpa, J.. "HNF1ß drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC)". Tumor Biology 37 4 (2016): 4813-4829. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945529538&partnerID=MN8TOARS.
    10.1007/s13277-015-4290-5
  37. Leis, B.; Angelov, A.; Mientus, M.; Li, H.; Pham, V.T.T.; Lauinger, B.; Bongen, P.; et al. "Identification of novel esterase-active enzymes from hot environments by use of the host bacterium Thermus thermophilus". Frontiers in Microbiology 6 APR (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930942030&partnerID=MN8TOARS.
    10.3389/fmicb.2015.00275
  38. Borges, N.; Jorge, C.D.; Gonçalves, L.G.; Gonçalves, S.; Matias, P.M.; Santos, H.. "Mannosylglycerate: structural analysis of biosynthesis and evolutionary history". Extremophiles 18 5 (2014): 835-852. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929510245&partnerID=MN8TOARS.
    10.1007/s00792-014-0661-x
  39. Lamosa, P.; Rodrigues, M.V.; Gonçalves, L.G.; Carr, J.; Ventura, R.; Maycock, C.; Raven, N.D.; Santos, H.. "Organic solutes in the deepest phylogenetic branches of the Bacteria: Identification of a(1-6)glucosyl-a(1-2)glucosylglycerate in Persephonella marina". Extremophiles 17 1 (2013): 137-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871462775&partnerID=MN8TOARS.
    10.1007/s00792-012-0500-x
  40. Gonçalves, L.G.; Borges, N.; Serra, F.; Fernandes, P.L.; Dopazo, H.; Santos, H.. "Evolution of the biosynthesis of di-myo-inositol phosphate, a marker of adaptation to hot marine environments". Environmental Microbiology 14 3 (2012): 691-701. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857855641&partnerID=MN8TOARS.
    10.1111/j.1462-2920.2011.02621.x
  41. Serpa, J.; Caiado, F.; Carvalho, T.; Torre, C.; Gonçalves, L.G.; Casalou, C.; Lamosa, P.; et al. "Butyrate-rich colonic microenvironment is a relevant selection factor for metabolically adapted tumor cells". Journal of Biological Chemistry 285 50 (2010): 39211-39223. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649877232&partnerID=MN8TOARS.
    10.1074/jbc.M110.156026
  42. Gonçalves, L.G.; Lamosa, P.; Huber, R.; Santos, H.. "Di-myo-inositol phosphate and novel UDP-sugars accumulate in the extreme hyperthermophile Pyrolobus fumarii". Extremophiles 12 3 (2008): 383-389. http://www.scopus.com/inward/record.url?eid=2-s2.0-43049160683&partnerID=MN8TOARS.
    10.1007/s00792-008-0143-0
  43. Borges, N.; Gonçalves, L.G.; Rodrigues, M.V.; Siopa, F.; Ventura, R.; Maycock, C.; Lamosa, P.; Santos, H.. "Biosynthetic pathways of inositol and glycerol phosphodiesters used by the hyperthermophile Archaeoglobus fulgidus in stress adaptation". Journal of Bacteriology 188 23 (2006): 8128-8135. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751559039&partnerID=MN8TOARS.
    10.1128/JB.01129-06
  44. Costa, J.; Empadinhas, N.; Gonçalves, L.; Lamosa, P.; Santos, H.; Da Costa, M.S.. "Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii". Journal of Bacteriology 188 3 (2006): 1022-1030. http://www.scopus.com/inward/record.url?eid=2-s2.0-31344453995&partnerID=MN8TOARS.
    10.1128/JB.188.3.1022-1030.2006
  45. Lamosa, P.; Gonçalves, L.G.; Rodrigues, M.V.; Martins, L.O.; Raven, N.D.H.; Santos, H.. "Occurrence of 1-glyceryl-1-myo-inosityl phosphate in hyperthermophiles". Applied and Environmental Microbiology 72 9 (2006): 6169-6173. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748803006&partnerID=MN8TOARS.
    10.1128/AEM.00852-06
  46. Gonçalves, L.G.; Huber, R.; Da Costa, M.S.; Santos, H.. "A variant of the hyperthermophile Archaeoglobus fulgidus adapted to grow at high salinity". FEMS Microbiology Letters 218 2 (2003): 239-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642346782&partnerID=MN8TOARS.
    10.1016/S0378-1097(02)01146-1

Intellectual property

Patent
  1. Serpa, Jacinta; FILIPA AlexALEXANDRA DIAS MARTINS; DAVID ALEXANDRE DIAS VAN-DER KELLEN; FERNANDA MARIA GONÇALVES DA SILVA; SOFIA GOUVEIA PEREIRA FERNANDES; Gonçalves, Luís G; Pojo, Marta; et al. 2023. "GLUTAMINASE, METHODS AND USES THEREOF". Portugal.
  2. Dias, Dos Santos Maria Helena; Lamosa, António Pedro Miguel; Gonçalves, Luís; Viseu, Rodrigues Marta; Hammond, Raven Neil David. 2006. "Glycerophosphoinositol as a Stabilizer and/or Preservative of Biological Materials. (2005) European Patent Office, nº". Portugal.
    Expired

Other

Dataset
  1. Martins, Filipa; Renata Arada; Hélio Barros; Valentín Ceña; Vasco Bonifácio,; Gonçalves, Luís G; Serpa, Jacinta. Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM). Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to i. 2025.
    dx.doi.org/10.21228/M8KV62
  2. Gonçalves, Luís G. Integrated multi-omics unveil the impact of the phosphinic compounds, desmethylphosphinothricin and its keto-analogue, on Escherichia coli metabolism. https://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST003202. 2024.
    10.21228/M8QH90
  3. Gonçalves, Luís G. Metabolic profiling and synergistic therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells. https://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST003287. 2024.
    10.21228/M8253C
  4. Gonçalves, Luís G. Interaction between NSCLC cells, CD8+ T cells and immune checkpoint inhibitors potentiates coagulation and promotes metabolic remodeling- new cues on CAT-VTE. https://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST003286. 2023.
    10.21228/M85V5Z
  5. Gonçalves, Luís G. Pathogenic Staphylococcus epidermidis ICE25 response to skin and blood pH. https://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST002868. 2023.
    10.21228/M86M7M
  6. Gonçalves, Luís G. Mass Spectrometry-based Proteomic and Metabolomic profiling of serum samples for discovery and validation of Tuberculosis diagnostic biomarker signature. https://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST002428. 2023.
    10.21228/M8SM54
  7. Gonçalves, Luís G. Skin-to-blood pH shift triggers metabolome and proteome global remodelling in Staphylococcus epidermidis. https://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST002277. 2023.
    10.21228/M8898H
Other output
  1. PRODUCTION AND CONSUMPTION OF LACTATE IS RELATED TO THE HISTOLOGICAL TYPE IN UTERINE CERVIX CARCINOMAS. 2013. L. Silva; F. Brito; F. Silva; L. Neto; Luis G Goncalves; V. Maximo; S. Dias; Ana Felix; Jacinta Serpa. https://novaresearch.unl.pt/en/publications/d111158c-f985-4dad-8532-c45a2c81dc60.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/10/01 - Current Role of DNA-dependent signaling loop in the regulation of cancer metabolism
Co-supervisor
 Ciências da Saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/09/15 - Current Impact of ICI on the crosstalk between cancer and immune cells underlying CAT-VTE
Co-supervisor
 Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09/15 - Current Impact of starfish radial nerve cord regeneration on coelomocyte populations and coelomic epithelium biological/metabolic processes
Co-supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/01/01 - Current Elucidation of Staphylococcus epidermidis response to skin endogenous antimicrobial
Supervisor of Elisabete Cristina Cordeiro Morais
 Doctoral Programme in Nuclear Magnetic Resonance Applied to Chemistry, Materials and Biosciences (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/09/01 - Current Discovery of anti-TNF a agent´s efficacy in ankylosing spondylitis patients using a metabolomic approach
Co-supervisor of Tomás Ochôa-May
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/09/01 - Current Targeting glutamine availability: a new strategy to treat malignant gliomas
Co-supervisor of Filipa Alexandra Dias Martins
 Programa doutoral Ciências da Saúde da Faculdade de Ciências Médica (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09/01 - 2022/03/21 Non-invasive profile of ECM as a preimplantation genetic diagnosis for aneuploidy
Supervisor of Cassandra Francelina Sousa Santos
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022 - 2022 Non-invasive Profile of Embryo Culture Media as a Preimplantation Genetic Diagnosis for Aneuploidy
Supervisor
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2020/09/01 - 2021/11/25 Unravelling The Pivotal Metabolic Pathways of Malignant Gliomas
Co-supervisor
 Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09/01 - 2021/11/18 Metabolic and gene expression profiles related to EGFR mutation in lung cancer
Supervisor of Isabel Maria da Rocha da Costa Lemos
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2017 Insights into Acute Myeloid Leukaemia metabolism using NMR Spectroscopy.
Supervisor
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014 - 2014 The metabolism of central nervous system metastasis: cerebrospinal fluid metabolome
Supervisor
 Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/10/19 - 2016/10/21 3rd Inter-institutional postdoc retreat in Tróia (2016/10/19 - 2016/10/21)
Meeting (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Centro Champalimaud, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015/11/04 - 2015/11/06 2nd Annual joint Postdoctoral meeting (2015/11/04 - 2015/11/06)
Meeting (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Fundação Champalimaud, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Gulbenkian de Ciência, Portugal
2010/09/12 - 2010/09/16 8TH International Congress on Extremophiles (2010/09/12 - 2010/09/16)
Congress (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/07/09 Efeitos biológicos da matéria particulada atmosférica: citotoxicidade e alterações metabólicas em células pulmonares e neuronais
(Thesis) Main arguer
 Tatiana Deolinda dos Santos Teixeira da Silva (PhD)
Universidade de Aveiro, Portugal
2023/12/06 Relevância do metaboloma do plasma para o diagnóstico e estudo etiológico do Acidente Vascular Cerebral
(Thesis) Main arguer
 Celina Maria Serra Santos (Master)
2023/07/19 Relevância do metaboloma da urina para o diagnóstico e estudo etiológico do AVC
(Thesis) Main arguer
 Rita Gomes Cortez de Sousa (Master)
Universidade da Beira Interior, Portugal
2022/12/06 Structural characterization of the C-terminal domain of endolysin PlyMW2 and interaction with the peptidoglycan of Staphylococcus aureus
(Thesis) Main arguer
 Marlene Pimentel Leite (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/04/02 Cysteine, a facilitator of hypoxia adaptation and a promoter of drug-resistance : a new route to better diagnose and treat ovarian cancer patients
(Thesis) Arguer
 Ana Sofia de Almeida Costa Nunes (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Class in gel image analysis for protein quantification and sample preparation for protein MALDI-TOF analysis (10 hours total) Bioquímica para a Saúde Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/09/08 - Current Procedimentos Bioanalíticos Bioquímica para a Saúde (Mestrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019 - Current NMR metabolomics class (2 Hours) Bioquímica para a Saúde (Mestrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/02/01 - Current Metabolomics Biociências Moleculares (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2024/07/03 - 2024/07/07 Theoretical and Hands-on Course: NMR for Metabolic Profiling (Pós-Graduação) Universidade da Beira Interior, Portugal
2020/09 - 2024/02 NMR classes in Laboratory Techniques curricular unit Biotecnologia para a Sustentabilidade (Mestrado integrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/02 - 2022/07 Advanced Proteomics and Metabolomics Biologia Computacional e Bioinformática (Mestrado integrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/06/06 - 2022/06/09 Hands-on NMR-based Metabolomics: principles, methods and applications (Pós-Graduação) Universidade da Beira Interior, Portugal
2021/09/06 - 2021/10/08 Omics for studying stem cells in model and non-model aquatic invertebrate systems (Pós-Graduação)

Scientific expedition

Activity description Institution / Organization
2015/05/25 - 2015/06/06 EMEPC/PEPC/LUSO/2015 Estrutura de Missão para a Extensão da Plataforma Continental, Portugal
2014/06/02 - 2014/06/22 EMEPC/PEPC/LUSO/2014 Expedition to Atlantic ocean, near the Maxwell fracture to collected submarine samples with a remote operated vehicle. My objective was to collected new microorganisms of these environments. Estrutura de Missão para a Extensão da Plataforma Continental, Portugal
Distinctions

Other distinction

2007 Prémio Câmara Pestana 2006
2004 Gold Medal Award for poster in Extremophiles 2004