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I am a W3 Full Professor at the University Hospital in Tübingen, where I lead the Advanced Metabolic Imaging and Cell Engineering (AMICI) team. I have supervised, trained, and mentored several high school, undergraduate, and graduate students. To date, my scientific work has resulted in 48 publications in international journals and several prestigious awards. My research group focuses on understanding the physicochemical, biochemical, and biological properties of the next generation of non-invasive metabolic sensors for applications in translational biomedical and clinical sciences. We aim to translate new technologies for in vivo use and validate imaging biomarkers relevant to severe metabolic diseases such as cancer senescence, diabetes, neurodegeneration, cirrhosis, inflammation, and kidney failure. Our laboratory's multidisciplinary research combines advanced multimodal, multiparametric, and state-of-the-art hybrid imaging techniques, enabling accurate disease detection and the prediction of responses to personalized therapies. Our research topics include: 1. Multimodal/Hybrid Imaging of the microenvironment and immunotherapy 2. Hyperpolarized metabolism and (metal)omics 3. Functional quantitative imaging (next generation of imaging agents) 4. Metabolic profiling and aggressiveness
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Identification

Personal identification

Full name
Andre Ferreira Martins

Citation names

  • Martins, Andre F.
  • Andre F. Martins
  • AF Martins

Author identifiers

Ciência ID
931F-8493-9C96
ORCID iD
0000-0002-0171-0261

Email addresses

  • andre.martins@med.uni-tuebingen.de (Professional)

Websites

  • http://www.isct.uni-tuebingen.de/wsic/group/staff/staff-member/andre-martins/ (Professional)

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging
  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1) Upper intermediate (B2)
German Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2009 - 2013/11/11
Concluded
 Bioquimica / Quimica (Doutoramento)
Universidade de Coimbra, Portugal
"Targeted Multimodal Imaging Agents for the Detection of Aß Plaques in Alzheimer’s Disease" (THESIS/DISSERTATION)
2009/05/01 - 2013/11/10
Concluded
 Chimie du Vivant (Doctorat)
CNRS à Orléans, France
 Summa Cum Laude
2009 - 2009
Concluded
 Quimica (Mestrado)
Centre National de la Recherche Scientifique, France
"Gadolinium based contrast agents" (THESIS/DISSERTATION)
 16.2
2003 - 2008
Concluded
 Bioquimica (Licenciatura)
Universidade de Coimbra, Portugal
"Gadolinium based contrast agents" (THESIS/DISSERTATION)
 16.2
Affiliation

Science

Category
Host institution 		Employer
2019/02/04 - Current Principal Investigator (Research) Eberhard Karls Universität Tübingen, Germany
Werner Siemens Imaging Center, Germany
(...)

Positions / Appointments

Category
Host institution 		Employer
2013/11/23 - 2019/01/01 Instructor The University of Texas Southwestern Medical Center, United States
The University of Texas Southwestern Medical Center, United States

Others

Category
Host institution 		Employer
2025/01/20 - Current Editor Springer Nature New York, United States
Projects

Grant

Designation Funders
2024/08/01 - Current Mapping Tumor Metabolic Aggressiveness with hybrid PET/MR Shift Reagents In Vivo
516238665
Principal investigator
Deutsche Forschungsgemeinschaft, Germany
 Deutsche Forschungsgemeinschaft
Ongoing
2023/10/01 - Current Free radical hyperpolarizing agents for ultra-low field Overhauser MR
527345502
Principal investigator
Deutsche Forschungsgemeinschaft, Germany
 Deutsche Forschungsgemeinschaft
Ongoing
2021/01/01 - Current Towards Metabolic Profiling of Tumors in vivo
Fortune
Principal investigator
Eberhard Karls Universität Tübingen, Germany
Ongoing
2020/11/01 - Current Image-guided modulation of tumor aggressiveness
Sofja Kovalevskaja Award
Principal investigator
Alexander von Humboldt-Stiftung, Germany
Ongoing
2020/06/01 - Current PET/MR Imaging of Macrophage Responses to Radiation and Immunotherapy
n/a
Principal investigator
Stanford University Department of Radiology
Ongoing
2018/09/01 - 2023/08/30 Imaging glucose-stimulated zinc secretion (GSZS) from the prostate by MRI: A potentially powerful method for early detection of prostate cancer
RP180178
Other
Cancer Prevention and Research Institute of Texas, United States
 Cancer Prevention and Research Institute of Texas
Ongoing
2012/09/19 - 2023/08 Imaging beta cell function in vivo with a Zinc responsive MRI contrast agent
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES/4R01DK095416-05/US
National Institute of Diabetes and Digestive and Kidney Diseases, United States
 National Institutes of Health
Ongoing
2020/02/01 - 2023/01/31 Towards Metabolic Profiling of Tumours in vivo
NWG_UKT_AnFM
Principal investigator
Eberhard Karls Universität Tübingen, Germany
 Eberhard Karls Universität Tübingen
Ongoing

Contract

Designation Funders
2013/01/01 - 2015/12/31 Do espaço químico à função biológica: uma viagem pela mão da UC-NMR
RECI/QEQ-QFI/0168/2012
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Freidel, L.; Li, S.; Choffart, A.; Kuebler, L.; Martins, A.F.. "Imaging Techniques in Pharmacological Precision Medicine". 213-235. 2023.
    10.1007/164_2023_641
Journal article
  1. Remy Chiaffarelli; Pedro F. Cruz; Jonathan Cotton; Tjark Kelm; Slade Lee; Mohammad Ghaderian; Max Zimmermann; et al. "Metabolic PCTA-Based Shift Reagents for the Detection of Extracellular Lactate Using CEST MRI". JACS Au (2025): https://doi.org/10.1021/jacsau.4c01020.
    10.1021/jacsau.4c01020
  2. Archibald, S.J.; Holland, J.P.; Korde, A.; Martins, A.F.; Shuhendler, A.J.; Scott, P.J.H.. "Combining Nuclear Medicine With Other Modalities: Future Prospect for Multimodality Imaging". Molecular Imaging 23 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85192080450&partnerID=MN8TOARS.
    10.1177/15353508241245265
  3. Kretschmer, Jan; Chiaffarelli, Remy; Vuozzo, Marta; Cotton, Jonathan; Blahut, Jan; Ralis, Jan; Dracinsky, Martin; et al. "A Macrocyclic Hybrid PET/MRI Probe for Quantitative Perfusion Imaging In Vivo". Angewandte Chemie International Edition (2024): https://publons.com/wos-op/publon/69319126/.
    10.1002/ANIE.202409520
  4. Meng, J.-H.; Huang, Y.-B.; Long, J.; Cai, Q.-C.; Qiao, X.; Zhang, Q.-L.; Zhang, L.-D.; et al. "Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS". iScience 27 4 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85189562543&partnerID=MN8TOARS.
    10.1016/j.isci.2024.109469
  5. Paranawithana, N.N.; Chiaffarelli, R.; Kretschmer, J.; Buchanan, E.; Lopez, K.; Zhao, P.; Kiefer, G.; et al. "Enhancing r1 Relaxivity in GdDOTA-Monoamide Complexes through Polar Group-Mediated Ordering of Second-Sphere Water Molecules". Inorganic Chemistry 63 9 (2024): 4072-4077. http://www.scopus.com/inward/record.url?eid=2-s2.0-85186247533&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.3c03639
  6. Knopf, P.; Stowbur, D.; Hoffmann, S.H.L.; Hermann, N.; Maurer, A.; Bucher, V.; Poxleitner, M.; et al. "Acidosis-mediated increase in IFN-¿-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors". Molecular Cancer 22 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85179703345&partnerID=MN8TOARS.
    10.1186/s12943-023-01900-0
  7. Andre Martins; E. Dao; M.V. Clavijo Jordan; K. Geraki; A.F. Martins; S. Chirayil; A.D. Sherry; M.J. Farquharson. "Using micro-synchrotron radiation x-ray fluorescence (µ-SRXRF) for trace metal imaging in the development of MRI contrast agents for prostate cancer imaging". Journal of Trace Elements in Medicine and Biology 74 (2022): 127054-127054. http://dx.doi.org/10.1016/j.jtemb.2022.127054.
    10.1016/j.jtemb.2022.127054
  8. Korde, A.; Mikolajczak, R.; Kolenc, P.; Bouziotis, P.; Westin, H.; Lauritzen, M.; Koole, M.; et al. "Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals". EJNMMI Radiopharmacy and Chemistry 7 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85134421157&partnerID=MN8TOARS.
    10.1186/s41181-022-00168-x
  9. Zhang, Y.; Zhao, K.; He, H.; Wan, S.; Martins, A.F.; Zhang, L.; Liu, K.. "AT2exMRI Dy-based contrast agent for direct pH imaging using a ratiometric approach". Dalton Transactions 50 6 (2021): 2014-2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100880883&partnerID=MN8TOARS.
    10.1039/d0dt03734f
  10. Anbu, S.; Hoffmann, S.H.L.; Carniato, F.; Kenning, L.; Price, T.W.; Prior, T.J.; Botta, M.; Martins, A.F.; Stasiuk, G.J.. "A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent". Angewandte Chemie - International Edition 60 19 (2021): 10736-10744. http://www.scopus.com/inward/record.url?eid=2-s2.0-85103980307&partnerID=MN8TOARS.
    10.1002/anie.202100885
  11. Ozbakir, H.F.; Miller, A.D.C.; Fishman, K.B.; Martins, A.F.; Kippin, T.E.; Mukherjee, A.. "A Protein-Based Biosensor for Detecting Calcium by Magnetic Resonance Imaging". ACS Sensors 6 9 (2021): 3163-3169. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114471642&partnerID=MN8TOARS.
    10.1021/acssensors.1c01085
  12. Chirayil, S.; Jordan, V.C.; Martins, A.F.; Paranawithana, N.; Ratnakar, S.J.; Sherry, A.D.. "Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI". Inorganic Chemistry 60 4 (2021): 2168-2177. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100803892&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.0c02688
  13. Veronica Clavijo Jordan; Alia Al-Ebraheem; Kalotina Geraki; Erica Dao; Andre F. Martins; Sara Chirayil; Michael Farquharson; A. Dean Sherry. "Synchrotron Radiation X-ray Fluorescence Elemental Mapping in Healthy versus Malignant Prostate Tissues Provides New Insights into the Glucose-Stimulated Zinc Trafficking in the Prostate As Discovered by MRI". Inorganic Chemistry (2019): https://doi.org/10.1021/acs.inorgchem.9b01132.
    10.1021/acs.inorgchem.9b01132
  14. Namini N. Paranawithana; Andre F. Martins; Veronica Clavijo Jordan; Piyu Zhao; Sara Chirayil; Gabriele Meloni; A. Dean Sherry. "A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo". Journal of the American Chemical Society (2019): https://doi.org/10.1021/jacs.8b13493.
    10.1021/jacs.8b13493
  15. Daniel Parrott; W. Shirangi Fernando; Andre Martins. "Smart MRI Agents for Detecting Extracellular Events In Vivo: Progress and Challenges". Inorganics (2019): http://www.mdpi.com/2304-6740/7/2/18.
    10.3390/inorganics7020018
  16. André F. Martins; Veronica Clavijo Jordan; Filip Bochner; Sara Chirayil; Namini Paranawithana; Shanrong Zhang; Su-Tang Lo; et al. "Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions". Journal of the American Chemical Society (2018): https://doi.org/10.1021/jacs.8b07607.
    10.1021/jacs.8b07607
  17. Martins, Andre. "Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor". Molecular Pharmaceutics (2018): http://dx.doi.org/10.1021/acs.molpharmaceut.8b00262.
    10.1021/acs.molpharmaceut.8b00262
  18. Lei Zhang; André F. Martins; Piyu Zhao; Yunkou Wu; Gyula Tircsó; A. Dean Sherry; Martins, Andre. "Lanthanide-Based T2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents". Angewandte Chemie 129 52 (2017): 16853-16857. https://doi.org/10.1002/ange.201707959.
    10.1002/ange.201707959
  19. Lei Zhang; Osasere M. Evbuomwan; Michael Tieu; Piyu Zhao; Andre F. Martins; A. Dean Sherry. "Protonation of carboxyl groups in EuDOTA-tetraamide complexes results in catalytic prototropic exchange and quenching of the CEST signal". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 375 2107 (2017): 20170113-20170113. https://doi.org/10.1098/rsta.2017.0113.
    10.1098/rsta.2017.0113
  20. Martins, Andre. "Transition Metal Doping Reveals Link Between Electron T1 Reduction and 13C Dynamic Nuclear Polarization Efficiency.". The journal of physical chemistry. A (2017): http://europepmc.org/abstract/med/29125294.
    10.1021/acs.jpca.7b09448
  21. Martins, Andre. "Enantiomeric recognition of D- and L-lactate by CEST with the aid of a paramagnetic shift reagent.". Journal of the American Chemical Society (2017): http://europepmc.org/abstract/med/29083166.
    10.1021/jacs.7b08292
  22. Martins, Andre. "Zinc as an Imaging Biomarker of Prostate Cancer". Israel Journal of Chemistry (2017): http://dx.doi.org/10.1002/ijch.201700043.
    10.1002/ijch.201700043
  23. Zohreh Hashami; Andre F. Martins; Alexander M. Funk; Veronica Clavijo Jordan; Stéphane Petoud; Svetlana V. Eliseeva; Zoltan Kovacs; Martins, Andre. "Lanthanide DO3A-Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium". European Journal of Inorganic Chemistry 2017 43 (2017): 4965-4968. https://doi.org/10.1002%2Fejic.201701003.
    10.1002/ejic.201701003
  24. Lei Zhang; André F. Martins; Yuyan Mai; Piyu Zhao; Alexander M. Funk; M. Veronica Clavijo Jordan; Shanrong Zhang; et al. "Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent". Chemistry - A European Journal (2017): https://doi.org/10.1002%2Fchem.201604558.
    10.1002/chem.201604558
  25. Niedbalski, P.; Parish, C.; Kiswandhi, A.; Fidelino, L.; Khemtong, C.; Hayati, Z.; Song, L.; et al. "Influence of Dy3+ and Tb3+ doping on 13C dynamic nuclear polarization". Journal of Chemical Physics 146 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008690486&partnerID=MN8TOARS.
    10.1063/1.4973317
  26. Cemile Kumas; W. Shirangi Fernando; Piyu Zhao; Martín Regueiro-Figueroa; Garry E. Kiefer; André F. Martins; Carlos Platas-Iglesias; A. Dean Sherry. "Unexpected Changes in the Population of Coordination Isomers for the Lanthanide Ion Complexes of DOTMA–Tetraglycinate". Inorg. Chem. (2016): http://dx.doi.org/10.1021/acs.inorgchem.6b01390.
    10.1021/acs.inorgchem.6b01390
  27. W. Shirangi Fernando; André F. Martins; Piyu Zhao; Yunkou Wu; Garry E. Kiefer; Carlos Platas-Iglesias; A. Dean Sherry. "Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents". Inorg. Chem. (2016): http://dx.doi.org/10.1021/acs.inorgchem.5b02850.
    10.1021/acs.inorgchem.5b02850
  28. Andhika Kiswandhi; Peter Niedbalski; Christopher Parish; Pavanjeet Kaur; André Martins; Leila Fidelino; Chalermchai Khemtong; et al. "Impact of Ho3+-doping on13C dynamic nuclear polarization using trityl OX063 free radical". Phys. Chem. Chem. Phys. 18 31 (2016): 21351-21359. http://dx.doi.org/10.1039/c6cp03954e.
    10.1039/c6cp03954e
  29. Damien Cressier; Martine Dhilly; Thang T. Cao Pham; Fabien Fillesoye; Fabienne Gourand; Auriane Maïza; André F. Martins; et al. "Gallium-68 Complexes Conjugated to Pittsburgh Compound B: Radiolabeling and Biological Evaluation". Mol Imaging Biol (2015): http://dx.doi.org/10.1007/s11307-015-0906-9.
    10.1007/s11307-015-0906-9
  30. André F. Martins; Alexandre C. Oliveira; Jean-François Morfin; Douglas V. Laurents; Éva Tóth; Carlos F. G. C. Geraldes. "Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aß amyloid aggregates". J Biol Inorg Chem (2015): http://dx.doi.org/10.1007/s00775-015-1316-9.
    10.1007/s00775-015-1316-9
  31. Yu J; Martins AF; Preihs C; Clavijo Jordan V; Chirayil S; Zhao P; Wu Y; et al. "Amplifying the Sensitivity of Zinc(II) Responsive MRI Contrast Agents by Altering Water Exchange Rates.". (2015): http://europepmc.org/abstract/med/26462412.
  32. Luis M. De León-Rodríguez; André F. Martins; Marco C. Pinho; Neil M. Rofsky; A. Dean Sherry. "Basic MR relaxation mechanisms and contrast agent design". J. Magn. Reson. Imaging 42 3 (2015): 545-565. http://dx.doi.org/10.1002/jmri.24787.
    10.1002/jmri.24787
  33. André F. Martins; David M. Dias; Jean-François Morfin; Sara Lacerda; Douglas V. Laurents; Éva Tóth; Carlos F. G. C. Geraldes. "Interaction of PiB-Derivative Metal Complexes with Beta-Amyloid Peptides: Selective Recognition of the Aggregated Forms". Chem. Eur. J. 21 14 (2015): 5413-5422. http://dx.doi.org/10.1002/chem.201406152.
    10.1002/chem.201406152
  34. Yu, J.; Martins, A.F.; Preihs, C.; Clavijo Jordan, V.; Chirayil, S.; Zhao, P.; Wu, Y.; et al. "Amplifying the Sensitivity of Zinc(II) Responsive MRI Contrast Agents by Altering Water Exchange Rates". Journal of the American Chemical Society 137 44 (2015): 14173-14179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947460644&partnerID=MN8TOARS.
    10.1021/jacs.5b09158
  35. Martins, André F.; Eliseeva, Svetlana V.; Carvalho, Henrique F.; Teixeira, João M. C.; Paula, Carlos T. B.; Hermann, Petr; Platas-Iglesias, Carlos; et al. "A Bis(pyridine N-oxide) Analogue of DOTA: Relaxometric Properties of the GdIII Complex and Efficient Sensitization of Visible and NIR-Emitting Lanthanide(III) Cations Including PrIII and HoIII". Chemistry – A European Journal (2014): n/a-n/a.
    10.1002/chem.201403856
  36. Monteiro, João P.; Martins, André F.; Nunes, Cláudia; Morais, Catarina M.; Lúcio, Marlene; Reis, Salette; Pinheiro, Teresa J.T.; et al. "A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 8 (2013): 1899-1908.
    Published • 10.1016/j.bbamem.2013.04.006
  37. Martins, André F.; Prata, M. I. M.; Rodrigues, S. P. J.; Geraldes, Carlos F. G. C.; Riss, P. J.; Amor-Coarasa, A.; Burchardt, C.; Kroll, C.; Roesch, F.. "Spectroscopic, radiochemical, and theoretical studies of the Ga 3+ - N -2-hydroxyethyl piperazine- N '-2-ethanesulfonic acid (HEPES buffer) system: evidence for the formation of Ga 3+ - HEPES complexes in 68 ¿Ga labeling reactions". Contrast Media & Molecular Imaging 8 3 (2013): 265-273.
    Published • 10.1002/cmmi.1517
  38. Martins, André F.; Morfin, Jean-François; Kubicekova, Anna; kubicek; Buron, Frédéric; Suzenet, Franck; Salerno, Milena; et al. "PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of ß-Amyloid Plaques". ACS Medicinal Chemistry Letters 4 5 (2013): 436-440.
    Published • 10.1021/ml400042w
  39. Mendonça, Ana C.; Martins, André F.; Melchior, Andrea; Marques, Sérgio M.; Chaves, Sílvia; Villette, Sandrine; Petoud, Stéphane; et al. "New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties". Dalton Transactions 42 17 (2013): 6046-6046.
    Published • 10.1039/C2DT32237D
  40. Martins, Andre Ferreira; Ferreira, Miguel F.; Martins, Catarina; Martins, José A.; Tóth, Éva; Rodrigues, Tiago; Geraldes, Carlos F.G.C.; Cerdan, Sebastian; Lopez-Larrubia, Pilar. "Amide conjugates of the DO3A-N-(a-amino)propionate ligand: leads for stable, high relaxivity contrast agents for MRI?". Contrast Media & Molecular Imaging 8 1 (2013): 40-49.
    Published
  41. Martins, André F.; Morfin, Jean-François; Geraldes, Carlos F. G. C.; Tóth, Éva. "Gd3+ complexes conjugated to Pittsburgh compound B: potential MRI markers of ß-amyloid plaques". JBIC Journal of Biological Inorganic Chemistry (2013):
    10.1007/s00775-013-1055-8
  42. Ferreira, M. F.; Pereira, G.; Martins, A. F.; Martins, C. I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; et al. "Ln[DO3A-N-a-(pyrenebutanamido)propionate] complexes: optimized relaxivity and NIR optical properties". Dalton Transactions (2013):
    10.1039/c3dt52958d
  43. Ferreira, M.F.; Martins, A.F.; Martins, C.I.O.; Ferreira, P.M.; Tóth, E.; Rodrigues, T.B.; Calle, D.; et al. "Amide conjugates of the DO3A-N-(a-amino)propionate ligand: Leads for stable, high relaxivity contrast agents for MRI?". Contrast Media and Molecular Imaging 8 1 (2013): 40-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868094442&partnerID=MN8TOARS.
    10.1002/cmmi.1492
  44. Lima, Luís M. P.; Delgado, Rita; Hermann, Petr; Šev¿?ík, Radek; Lubal, Premysl; Carvalho, Henrique F.; Martins, André F.; Tóth, Éva; Geraldes, Carlos F. G. C.. "Tris(phosphonomethyl)cyclen Derivatives: Thermodynamic Stability, Kinetics, Solution Structure, and Relaxivity of Ln3+ Complexes". European Journal of Inorganic Chemistry 2012 15 (2012): 2548-2559.
    Published • 10.1002/ejic.201101335
  45. Monteiro, João P.; Martins, André F.; Lúcio, Marlene; Reis, Salette; Geraldes, Carlos F. G. C.; Oliveira, Paulo J.; Jurado, Amália S.. "Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling". Journal of Bioenergetics and Biomembranes 43 3 (2011): 287-298.
    Published • 10.1007/s10863-011-9359-2
  46. Monteiro, João P.; Martins, André F.; Lúcio, Marlene; Reis, Salette; Pinheiro, Teresa J.T.; Geraldes, Carlos F.G.C.; Oliveira, Paulo J.; Jurado, Amália S.. "Nimesulide interaction with membrane model systems: Are membrane physical effects involved in nimesulide mitochondrial toxicity?". Toxicology in Vitro 25 6 (2011): 1215-1223.
    Published • 10.1016/j.tiv.2011.05.014
  47. Chaves, Sílvia; Mendonça, Ana C.; Marques, Sérgio M.; Prata, M. Isabel; Santos, Ana C.; Martins, André F.; Geraldes, Carlos F.G.C.; Santos, M. Amélia. "A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging: solution and in vivo studies of 67Ga-labeled species". Journal of Inorganic Biochemistry 105 1 (2011): 31-38.
    Published • 10.1016/j.jinorgbio.2010.09.012
  48. Silvério, Sara; Torres, Susana; Martins, André F.; Martins, José A.; André, João P.; Helm, Lothar; Prata, M. Isabel M.; Santos, Ana C.; Geraldes, Carlos F. G. C.. "Lanthanide chelates of (bis)-hydroxymethyl-substituted DTTA with potential application as contrast agents in magnetic resonance imaging". Dalton Transactions 24 (2009): 4656-4656.
    Published • 10.1039/b823402g
  49. Ferreira, Miguel F.; Martins, André F.; Martins, José A.; Ferreira, Paula M.; Tóth, Éva; Geraldes, Carlos F.G.C.. "Gd(DO3A-N-a-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents". Chemical Communications 42 (2009): 6475-6475.
    Published • 10.1039/b912201j
Preprint
  1. Remy Chiaffarelli; Pedro Cruz; Max Zimmermann; Carlos F. G. C. Geraldes; Paul Jurek; Andre F. Martins. "Metabolic PCTA-Based Shift Reagents for the Selective Detection of Extracellular Lactate Using CEST MRI". 2024. https://doi.org/10.1101/2024.07.09.602789.
    10.1101/2024.07.09.602789

Intellectual property

Patent
  1. Mn(II)-based sensors to detect zinc in vivo with MRI. 2024. "Chirayl S, Martins AF, Clavijo-Jordan V, Sherry AD. Mn(II)-based sensors to detect zinc in vivo with MRI". United States.
    Granted/Issued
  2. Namini Paranawithana; AF Martins; Sherry AD. 2021. "A pH-sensitive MRI Contrast Agent-Based on GdDOTA-Monoamide Methylene Phosphate". United States.
    Granted/Issued
  3. AF Martins. 2019. "Zinc sensors for in vivo imaging of ¿-cell function by MRI". United States.
    Granted/Issued

Other

Other output
  1. Acidosis-mediated increase in IFN-¿-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors. 2023. Knopf, P.; Stowbur, D.; Hoffmann, S.H.L.; Hermann, N.; Maurer, A.; Buchner, V.; Poxleitner, M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85167648221&partnerID=MN8TOARS.
    10.21203/rs.3.rs-2816652/v1
  2. Using Micro-Synchrotron Radiation X-Ray Fluorescence (¿-Srxrf) for Trace Metal Imaging in the Development of MRI Contrast Agents for Prostate Cancer Imaging. 2022. Dao, E.; Jordan, M.V.C.; Geraki, K.; Martins, A.F.; Chirayil, S.; Sherry, A.D.; Farquharson, M.J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85176982380&partnerID=MN8TOARS.
    10.2139/ssrn.4007848
  3. A protein-based biosensor for detecting calcium by magnetic resonance imaging. 2021. Ozbakir, H.F.; Miller, A.D.C.; Fishman, K.B.; Martins, A.F.; Kippin, T.E.; Mukherjee, A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102224629&partnerID=MN8TOARS.
    10.1101/2021.02.04.429691
  4. A manganese(II)-Based Responsive Contrast Agent Detects Glucose- Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.. 2020. Chirayil, S.; Jordan, V.C.; Martins, A.F.; Paranawithana, N.; Ratnakar, S.J.; Sherry, A.D.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098900679&partnerID=MN8TOARS.
    10.26434/chemrxiv.12430082.v1
  5. A responsive MRI contrast agent for detection of excess copper(II) in the liver in vivo. 2018. Paranawithana, N.N.; Martins, A.F.; Clavijo-Jordan, V.; Zhao, P.; Chirayil, S.; Meloni, G.; Dean Sherry, A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095659776&partnerID=MN8TOARS.
    10.26434/chemrxiv.7359095.v1
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2007 - 2007 Vitor Madeira Conference
Conference (Other)
 NEBIOQ-AAC, Portugal
2007 - 2007 Nanotechnology
Symposium (Other)
 NEBIOQ, Portugal

Association member

Society Organization name Role
2004 - 2013 mRNA (NEBIOQ)
2010 - 2012 ANBIOQ
2008 - 2010 ANBIOQ
2007 - 2008 Academic Student Assotiation (AAC)
2006 - 2007 NEBIOQ
2006 - 2007 University Senate

Committee member

Activity description
Role 		Institution / Organization
2020 - Current Tubingen-Nothingahm Alliance
Member
 Eberhard Karls Universität Tübingen, Germany

University of Nottingham, United Kingdom

Conference scientific committee

Conference name Conference host
2019 - Current European Molecular Imaging Meeting

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024/12/01 - Current FCT
Specialist
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia

Journal scientific committee

Journal title (ISSN) Publisher
2025/01/01 - Current NPJ Imaging (2948-197X) Nature Springer
2020 - Current Pharmaceuticals (1424-8247) MDPI AG
2019 - Current Metabolites (2218-1989) MDPI AG
2013/07/20 - 2013/08/20 mRNA
Distinctions

Award

2024 Innovation Award “HYPERBOLIC”, DKTK, Germany
Deutsches Konsortium für Translationale Krebsforschung, Germany
2024 “Leme do Ano” Excellence and Recognition, Award, City Aveiro, Portugal
Câmara Municipal de Aveiro, Portugal
2021 Dr. K. H. Eberle Preise/Dr. K. H. Eberle Stiftung, Germany
2020 Sofja Kovalevskaja Award 2020
Alexander von Humboldt-Stiftung, Germany
2018 Best Presentation Award
International Society for Magnetic Resonance in Medicine, United States
2018 Seal of Excellence, Horizon 2020, European Commission
Conseil de l'Union Europeenne, Belgium
2017 Travel award, World Molecular Imaging Society
World Molecular Imaging Society, United States

Title

2025 Elected Board Member, ESMI, European Society for Molecular Imaging
European Society for Molecular Imaging , Germany
2022 W3-Professor in Advanced Preclinical Imaging and Cell Engineering/Humboldt Foundation, University of Tübingen, Tübingen, Germany
Eberhard Karls Universität Tübingen, Germany
2022 Deputy elected Associate PI assembly, iFIT Cluster of Excellence/Deutsche Forschungsgemeinschaft (DFG), Germany
Deutsche Forschungsgemeinschaft, Germany
2019 Junior Academy Member of the Faculty of Medicine, University of Tuebingen
Eberhard Karls Universität Tübingen, Germany
2017 Chair at the Annual ACS Meeting San Francisco
American Chemical Society, United States

Other distinction

2017 Qualification Maitre de Conférences Section 64
Gouvernement francais Ministere de l'education nationale, France
2012 Biotechnocentre Best Poster Presentation Award (France)
Region Centre, Portugal
2011 ESMI Poster Award within the category “Probe Design” in the field of Molecular Imaging (The Netherlands)
ESMI, Portugal
1996 National Vice Champion in Canoeing K1 Cadet
FPC, Portugal