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I graduated in Biology with specialization in Cellular Biology and Biotechnology (14/20) in 2017 at Faculdade de Ciências da Universidade de Lisboa (FCUL). During my bachelor's degree, I joined the Plant Biotechnology Centre (CVB-CESAM) at FCUL as an undergraduate trainee. After graduation, I was awarded two research fellowships at CBV-CESAM, under the scope of PDR 2020 funding projects (MACFERTIQUAL and SafeApple), where I remained as a research fellow until 2019. In 2018, I started my master's degree in Biotechnology for Sustainability (18/20) at ITQB NOVA, and for my master's dissertation, I worked at the Microbial and Enzyme Technology (MET Lab) group under the supervision of Professor Lígia O. Martins on the engineering of a Dye-decolorizing peroxidase, BsDyP, a bacterial peroxidase capable of oxidizing lignin-related compounds, that can be applied in lignocellulose biorefineries. The results obtained throughout this period were published in a paper (Rodrigues*, Borges*, et al, 2021, IJMS, *first equal author). After finishing my master's degree, I was awarded a research fellowship at MET Lab, within the EU-funded SMARTBOX project (Selective Modifications of Aromatics through Biocatalytic Oxidations). In 2022, I started my PhD in Molecular Biosciences (ITQB NOVA) fellowship, which will focus on the evolution and biochemical characterization of BsDyP and its improvement towards biotechnological applications. I have 2 research publications, 1 review publication, and 7 poster communications in national or international congresses. I have been involved in the co-supervision of undergraduate students in their final bachelor's degree project. I have been actively involved in several outreach activities such as the European Night of Researchers and ITQB Open Day.
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Identification

Personal identification

Full name
Carolina Ferro Rodrigues

Citation names

  • Rodrigues, Carolina
  • Rodrigues, C. F.

Author identifiers

Ciência ID
9316-7825-522F

Email addresses

  • carolinafrodrigues@itqb.unl.pt (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022 - 2026
Ongoing
 Biociências Moleculares (Doutoramento)
Major in Molecular Mechanisms of Biological Processes
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/06/09
Concluded
 Biotecnologia para a Sustentabilidade (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Tailor BsDyP for Biorefinery Applications using a Laboratory Enzyme Evolution Approach" (THESIS/DISSERTATION)
 18
2017/07/14
Concluded
 Biologia (Licenciatura)
Major in Biologia Celular e Biotecnologia
Universidade de Lisboa Faculdade de Ciências, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2021 - 2022/01/01 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018 - 2019 Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Estudos do Ambiente e do Mar, Portugal
(...)
2015 - 2018 Research Trainee (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Estudos do Ambiente e do Mar, Portugal
(...)
Projects

Grant

Designation Funders
2021/09 - 2022/01 SMARTBOX - Selective Modifications of Aromatics through Biocatalytic Oxidations
info:eu-repo/grantAgreement/EC/H2020/837890/EU
Research Fellow
European Commission
2019/03 - 2019/08 SafeApple - Conservação da Qualidade da Maçã de Alcobaça: objetivo resíduos zero
PDR2020-101-031742
Research Fellow
2018/09 - 2019/02 MACFERTIQUAL
PDR2020-101-031606
Research Fellow
Outputs

Publications

Conference poster
  1. Rodrigues, C. F.; Silva, Diogo; Martins, LO. "Biochemical and Catalytic Analysis of Computationally Designed Hyperthermostable Bacterial DyP-type Peroxidases". Paper presented in 16th Biotrans, 2023.
  2. Rodrigues, C. F.; Silva, Diogo; Lorena, Constança; Durão, P; Borges, PT; Martins, LO. "Enzyme Engineering contributes to unravelling residue networks of molecular interactions on hyperstable PpDyP variants". Paper presented in 7th NovelEnzymes, 2023.
  3. Rodrigues, Carolina; Borges, Patricia T.; Scocozza, Magali F.; Silva, Diogo; Taborda, André; Brissos, Vânia; Carlos Frazao; Martins, Lígia. "Unraveling the role of conserved loops around the heme pocket in the function and stability of BsDyP". Paper presented in 10th Oxizymes Meeting, 2022.
  4. Rodrigues, Carolina; Borges, Patricia T.; Brissos, Vânia; Taborda, André; Martins, Lígia O.. "Biochemical, kinetic, and structural analysis of a BsDyP hit variant with improved activity for phenolic compounds". Paper presented in 3rd Aachen Protein Engineering Symposium (AcES), 2021.
  5. Rodrigues, Carolina; Brissos, Vânia; Taborda, André; Martins, Lígia O.. "Improving the activity of BsDyP for phenolic compounds using a laboratory evolution approach". Paper presented in EFB2021, 2021.
  6. Rodrigues, Carolina; Brissos, Vânia; Martins, Lígia O.. "Tailor BsDyP for biorefinery applications using a laboratory enzyme evolution approach". Paper presented in Biocatalysis Open Day 2020, 2020.
  7. Rodrigues, Carolina; Brissos, Vânia; Martins, Lígia O.. "New enzymes for biorefinery applications: towards the production of bio-resins". Paper presented in Microbiotec ’19 Congress, 2019.
  8. Rodrigues, Carolina; Fonseca, M. B.; Reis, J. T.; Trindade, Helena; Figueiredo, Ana Cristina; Barroso, J.; Pedro, L. G.. "Seasonal variation of essential oil composition in Thymus caespititius, carvacrol chemotype". Paper presented in 50th International Symposium on Essential Oils, 2019.
  9. Rodrigues, Carolina; Melo, Juliana; Correia, P.; Gonçalves, M.; Pastaneira, Mafalda; Matos, A. R.; Cruz, C.; et al. "Effect of planting densities, pruning techniques and shelf life on Malus domestica ("Maçã de Alcobaça") headspace volatiles". Paper presented in 50th International Symposium on Essential Oils, 2019.
  10. Pastaneira, Mafalda; Rodrigues, Carolina; Melo, J.; Ramos, T.; Cruz, C.; Antunes, M.; Marques da Silva, J.; et al. "Characterization of physiological parameters and volatile components of "Maçã de Alcobaça" variety Royal Gala, grown under four types of fertilization". Paper presented in XVI Spanish Portuguese Congress of Plant Physiology, 2019.
Journal article
  1. Hermann, Eniko; Rodrigues, Carolina F.; Martins, Lígia O.; Peterbauer, Clemens; Oostenbrink, Chris. "Engineering A-type Dye-decolorizing Peroxidases by Modification of a Conserved Glutamate Residue". ChemBioChem (2024): http://dx.doi.org/10.1002/cbic.202300872.
    10.1002/cbic.202300872
  2. Barbosa, Catarina; Rodrigues, Carolina Ferro; Loncar, Nikola; Martins, Lígia O.; Todorovic, Smilja; Silveira, Célia M.. "Spectroelectrochemistry for determination of the redox potential in heme enzymes: Dye-decolorizing peroxidases". BBA Advances 5 (2024): 100112. http://dx.doi.org/10.1016/j.bbadva.2023.100112.
    10.1016/j.bbadva.2023.100112
  3. Tavares, Cláudia; Rodrigues, Carolina Ferro; Gonçalves, Elsa; Machado, Alexandra M.; Pedro, Luís; Barroso, José; Maurício, Anabela; et al. "Effects of Different Irrigation Regimes, Nitrogen Levels and Storage Conditions on Volatiles of ‘Gala’ Apple". Molecules 28 18 (2023): 6610. http://dx.doi.org/10.3390/molecules28186610.
    10.3390/molecules28186610
  4. Silva, Diogo; Rodrigues, Carolina Ferro; Lorena, Constança; Borges, Patrícia T.; Martins, Lígia O.. Corresponding author: Martins, Lígia O.. "Biocatalysis for biorefineries: The case of dye-decolorizing peroxidases". Biotechnology Advances 65 (2023): 108153. http://dx.doi.org/10.1016/j.biotechadv.2023.108153.
    10.1016/j.biotechadv.2023.108153
  5. Trindade, Helena; Rodrigues, Carolina Ferro; Tenreiro, Rogério; Tenreiro, Ana; Pedro, Luis Gaspar. Corresponding author: Trindade, Helena. "Terpene synthase gene expression evaluation through RT-qPCR in Thymus caespititius". Industrial Crops and Products 176 (2021): 114312. http://dx.doi.org/10.1016/j.indcrop.2021.114312.
    Published • 10.1016/j.indcrop.2021.114312
  6. Rodrigues, Carolina F.; Borges, Patrícia T.; Scocozza, Magali F.; Silva, Diogo; Taborda, André; Brissos, Vânia; Frazão, Carlos; Martins, Lígia O.. Corresponding author: Martins, Lígia O.. "Loops around the Heme Pocket Have a Critical Role in the Function and Stability of BsDyP from Bacillus subtilis". International Journal of Molecular Sciences 22 19 (2021): 10862. http://dx.doi.org/10.3390/ijms221910862.
    Published • 10.3390/ijms221910862
Activities

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/11/27 - Current Participation in the European Researchers Night 2020 representing the european RISE project Bligzymes through a cientific movie that exemplified the degradation of dyes by enzymes in a circular economy perspective.
Meeting
 European Researchers Night 2020
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal