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I am a passionate biomedical researcher with over seven years of experience in immunology, committed to making meaningful contributions to human health through impactful research on immune-related diseases. My academic journey began with a BSc in Biochemistry from the Faculty of Science and Technology of the University of Coimbra (2011–2014), followed by a MSc in Biomedical and Molecular Science Research from King’s College London (2015–2016). In April 2024, I earned my PhD in Biomedical Sciences, with a specialization in Immunology, awarded with Distinction and Honors through the Lisbon Biomedical and Clinical Research PhD Program at the Faculty of Medicine of the University of Lisbon, and Instituto de Medicina Molecular João Lobo Antunes. Currently, as a postdoctoral researcher in Luis Graça’s lab at the Gulbenkian Institute for Molecular Medicine (GIMM) in Lisbon, I focus on unraveling the molecular and cellular mechanisms underlying immune-related diseases, particularly autoimmune disorders. My work aims to improve diagnostics and drive innovative therapeutic solutions, contributing to a deeper understanding of immune system dysfunction and its broader implications.
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Identification

Personal identification

Full name
Filipa Ribeiro

Citation names

  • Ribeiro, Filipa

Author identifiers

Ciência ID
921E-0E21-9DFC
ORCID iD
0000-0001-7665-3436

Email addresses

  • filipa.ribeiro@gimm.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2018 - 2024/04
Concluded
 Biomedical Sciences (Lisbon Biomedical and Clinical Research PhD Program) (Doutoramento)
Major in Immunology
Universidade de Lisboa Faculdade de Medicina, Portugal
"Mechanisms of T follicular regulatory cell differentiation" (THESIS/DISSERTATION)
 Distinction and Honors
2015 - 2016
Concluded
 Biomedical and Molecular Science Research (Master)
King's College London, United Kingdom
"Investigating Abi3bp as a candidate direct target of Meox2 mediated senescence" (THESIS/DISSERTATION)
 Distinction (18)
2011 - 2014
Concluded
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Differential sensitivity of bladder carcinoma cell lines to cisplatinum and methotrexate" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2024/06/01 - Current Postdoc (Research) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2018/01 - 2024/05 Researcher (Research) Universidade de Lisboa Faculdade de Medicina, Portugal
Instituto de Medicina Molecular, Portugal
2019/05 - 2019/06 Visiting Researcher (Research) Icahn School of Medicine at Mount Sinai, United States
Icahn School of Medicine at Mount Sinai, United States
2019/01 - 2019/02 Visiting Researcher (Research) Institut Curie, France
Institut Curie, France
2017/03 - 2017/12 Researcher (Research) Instituto de Medicina Molecular, Portugal
2016/01 - 2016/10 Researcher (Research) King's College London Randall Division of Cell and Molecular Biophysics, United Kingdom
King's College London, United Kingdom
2014/01 - 2014/08 Research Trainee (Research) CNC.IBILI, Portugal
Universidade de Coimbra, Portugal
Projects

Grant

Designation Funders
2018/01 - 2022/05 Mechanisms of T follicular regulatory cell differentiation
PD/BD/135515/2018
PhD Student Fellow
Universidade de Lisboa Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2022 - 2022 Mechanisms of T follicular regulatory cell differentiation
COVID/BD/152517/2022
PhD Student Fellow
Universidade de Lisboa Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/01/01 - 2024/12/31 Targeting TLR2 for improved veterinary vaccines
PTDC/CVT-CVT/4599/2021
10.54499/PTDC/CVT-CVT/4599/2021
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/02/01 - 2024/07/31 Revelando os eventos moleculares de desregulação imunológica levando ao linfoma associado à Síndrome de Sjögren
2022.05498.PTDC
10.54499/2022.05498.PTDC
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Filipa Ribeiro; Michelle Linterman; Luis Graca. "T Follicular Helper Cells". 2023.
    10.1016/b978-0-12-821618-7.00137-1
  2. Filipa Ribeiro; Pedro Ávila-Ribeiro; João Eurico Fonseca; Luis Graca. "Identification of Human Blood and Tissue T Follicular Regulatory (Tfr) Cells by Flow Cytometry". 2022.
    10.1007/978-1-0716-1736-6_4
  3. Rodrigo Pedroso; Filipa Ribeiro; Ana Rita Pires; Luis Graca; Valter R. Fonseca. "Identification of Human T Follicular Cells in Ectopic Lymphoid Structures". 2022.
    10.1007/978-1-0716-1736-6_19
Journal article
  1. Rodrigo Balsinha Pedroso; Licia Torres; Lucas Araújo Ventura; Giovanna Caliman Camatta; Catarina Mota; Ana Catarina Mendes; Filipa Ribeiro; et al. "Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection". Journal of Leukocyte Biology (2024): http://dx.doi.org/10.1093/jleuko/qiae180.
    10.1093/jleuko/qiae180
  2. Saumya Kumar; Afonso P. Basto; Filipa Ribeiro; Silvia C. P. Almeida; Patricia Campos; Carina Peres; Nadia Pulvirenti; et al. "Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue". Cell Discovery (2024): http://dx.doi.org/10.1038/s41421-024-00681-0.
    10.1038/s41421-024-00681-0
  3. Filipa Ribeiro; Luis Graca. "T follicular regulatory cells keep B cell-directed autoreactivity in check". Cell Research (2024): http://dx.doi.org/10.1038/s41422-024-00941-4.
    10.1038/s41422-024-00941-4
  4. Matos, Ana I. I.; Peres, Carina; Carreira, Barbara; Moura, Liane I. F.; Acurcio, Rita C. C.; Vogel, Theresa; Wegener, Erik; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science (2023): https://publons.com/wos-op/publon/55939439/.
    10.1002/ADVS.202300299
  5. Filipa Ribeiro; Vasco C. Romão; Sara Rosa; Kátia Jesus; Ana Água-Doce; Sofia C. Barreira; Patrícia Martins; et al. "Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation". Scientific Reports (2022): http://dx.doi.org/10.1038/s41598-022-21576-8.
    10.1038/s41598-022-21576-8
  6. Filipa Ribeiro; Esperanza Perucha; Luis Graca. "T follicular cells: The regulators of germinal center homeostasis". Immunology Letters (2022): https://doi.org/10.1016/j.imlet.2022.02.008.
    10.1016/j.imlet.2022.02.008
  7. Saumya Kumar; Válter R. Fonseca; Filipa Ribeiro; Afonso P. Basto; Ana Água-Doce; Marta Monteiro; Dikélélé Elessa; et al. "Developmental bifurcation of human T follicular regulatory cells". Science Immunology (2021): https://doi.org/10.1126/sciimmunol.abd8411.
    10.1126/sciimmunol.abd8411
  8. Fonseca, Válter R.; Ribeiro, Filipa; Graca, Luis. "T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr-cell compartments". Immunological Reviews 288 1 (2019): 112-127. http://dx.doi.org/10.1111/imr.12739.
    10.1111/imr.12739
  9. Valter R. Fonseca; Ana Agua-Doce; Ana Raquel Maceiras; Wim Pierson; Filipa Ribeiro; Vasco C. Romão; Ana Rita Pires; et al. "Human blood T fr cells are indicators of ongoing humoral activity not fully licensed with suppressive function". Science Immunology 2 14 (2017): eaan1487-eaan1487. https://doi.org/10.1126%2Fsciimmunol.aan1487.
    10.1126/sciimmunol.aan1487
Preprint
  1. Rodrigo B. Pedroso; Araújo Ventura, Lucas Haniel; Torres, Lícia; Camatta, Giovanna Caliman; Caixeta, Felipe; Nascimento, Leandro Souza; Mota, Catarina; et al. Corresponding author: Caetano Faria, Ana Maria. "Covid-19 induces senescence and exhaustion of T cells in patients with mild/moderate and severe disease during a seven-day interval". 2023. http://dx.doi.org/10.1101/2023.01.16.23284612.
    10.1101/2023.01.16.23284612
  2. Saumya Kumar; Afonso P. Basto; Filipa Ribeiro; Silvia C. P. Almeida; Patricia Campos; Carina Peres; Sarwah Al-Khalidi; et al. "Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue". 2022. https://doi.org/10.1101/2022.07.28.501817.
    10.1101/2022.07.28.501817
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07 Dynamic heterogeneity of T regulatory cells in murine lymph nodes during humoral responses EMBO Workshop Lymphatic tissues and germinal centres in immune reactions
EMBO (Galway, Ireland)
2024/04 Dynamic heterogeneity of T regulatory cells in murine lymph nodes during humoral responses XLIX Annual Meeting of the Portuguese Society for Immunology
Sociedade Portuguesa de Imunology (Porto, Portugal)
2023/11/15 Identification of human blood and tissue T follicular regulatory cells by flow cytometry
IFlow Club – Sociedad Española de Inmunología
2023/10/19 The heterogeneity of T follicular cells within human lymphoid tissues iMM Scientific Retreat
Instituto de Medicina Molecular
2023/10 PD-1 and ICOS are coherently expressed in T follicular helper cells but define three stages of maturation in T follicular regulatory cells T and B cell collaboration in germinal centers and beyond
Keystone Symposia (Whistler, Canada)
2022/05 Defining the differentiation of T follicular regulatory cells XV CAML · V NeuroULisboa PhD Students Meeting
Faculdade de Medicina da Universiade de Lisboa (Lisboa, Portugal)
2022/04 PD-1 and ICOS are co-expressed in T follicular helper cells but define two stages of maturation in T follicular regulatory cells XLVII Annual Meeting of the Portuguese Society for Immunology
Sociedade Portuguesa de Imunologia (Lisboa, Portugal)
2021/09 Defining the differentiation of T follicular regulatory cells 6th European Congress of Immunology
European Federation of Immunological Societies
2021/06 Defining the differentiation of T follicular regulatory cells XLVI Annual Meeting of the Portuguese Society for Immunology
Sociedade Portuguesa de Imunologia
2021/05 Defining the differentiation of T follicular regulatory cells XIV CAML · IV NeuroULisboa PhD Students Meeting
Faculdade de Medicina da Universidade de Lisboa (Lisboa, Portugal)
2018/05 Imbalance of blood Tfh and Tfr cells in systemic and organ-specific human autoimmunity 11th International Congress on Autoimmunity
(Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09 - Current Characterizing the heterogeneity and differentiation of mouse T follicular cells – one cell at a time
Supervisor
 Master in Computational Biology and Bioinformatics (Master)
Universidade Nova de Lisboa, Portugal
2022 - 2023 Functional heterogeneity between T follicular regulatory cells from different human compartments
Co-supervisor
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2020 Defining tissue T follicular regulatory cells
Co-supervisor
Université de Paris, France

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024 - 2024 The Hitchhiker’s Guide to scRNA-seq
Workshop
 The Hitchhiker’s Guide to scRNA-seq
Gulbenkian Institute for Molecular Medicine, Portugal
2019 - 2019 Course on Laboratory Animal Science (Function A)
Other
 Course on Laboratory Animal Science (Function A)
Congento Consortium for Genetically Tractable Organisms, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024 - 2024 Immunology Letters

Association member

Society Organization name Role
2017 - Current Sociedade Portuguesa de Imunologia Membro
Distinctions

Award

2024 Best PhD Thesis Award in Infection and Immunity
Universidade de Lisboa, Portugal
2022 Best Poster Presentation Award at the XLVII Annual Meeting of the Portuguese Society for Immunology
Sociedade Portuguesa de Imunologia, Portugal
2021 Merit Award for the presentation at XIV CAML · IV NeuroULisboa PhD Students Meeting
Centro Académico de Medicina de Lisboa, Portugal
2019 AAI Travel for Techniques Award
American Association of Immunologists Inc, United States
2019 R&D PhD Internship Grants in the USA
Fundação Luso-Americana, Portugal
2019 EMBO Short-Term Fellowship
EMBO Press, Germany
2018 EFIS-ACTERIA Travel Grant
European Federation of Immunological Societies, Netherlands