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Ana Tomás has a bachelor's degree in Molecular and Cellular Biology (completed in 2018), and a master's degree in Molecular Genetics and Biomedicine (completed in 2021), from Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa. She is currently doing her PhD in Health Sciences (Nova Medical School, Universidade Nova de Lisboa) at Instituto Português de Oncologia de Lisboa Francisco Gentil and Chronic Diseases Research Center (CEDOC). Ana Tomás has 2 articles published in scientific journals, and has presented 4 posters and 4 oral communications at scientific conferences.
Identification

Personal identification

Full name
Ana Catarina Serra Tomás
Date of birth
1997/03/20
Gender
Female

Citation names

  • Tomás, Ana

Author identifiers

Ciência ID
8F16-85EE-447D
ORCID iD
0000-0003-4710-2605

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2022/01/01 - 2026
Ongoing
 Health Sciences (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/09/03 - 2021/01/11
Concluded
 Genética Molecular e Biomedicina (Mestrado integrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Targeted inhibition of PIK3CA mutations in glioma cell models" (THESIS/DISSERTATION)
 19
2015/09 - 2018/06
Concluded
 Biologia Celular e Molecular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 18
Affiliation

Science

Category
Host institution 		Employer
2021/01/18 - 2021/11/12 Researcher (Research) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Projects

Grant

Designation Funders
2022/01/01 - Current Identifying potential predictive and prognostic immune biomarkers in cutaneous melanoma
2021.06204.BD
PhD Student Fellow
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/18 - 2021/11/12 Immune microenvironment in melanoma: clinical impact of regulatory T cells and tumor-associated macrophages in prognosis and response to therapy
Terry Fox 2020/2021
Research Fellow
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Liga Portuguesa Contra o Cancro
Concluded
2019/09/02 - 2020 PIK3CA mutation in gliomas: Clinical impact and Pharmacological inhibition
Terry Fox 2018/2020
Master Student Fellow
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Liga Portuguesa Contra o Cancro
Outputs

Publications

Conference poster
  1. Tomás, Ana; Maximino, José A; Nunes, Hugo; Gonçalves, Filipe; Farricha, Victor; Carvalho, Elisabete Lopez; Cristóvão-Ferreira, Sofia; et al. "Activated CD4+ T cells as prognostic and predictive biomarkers in cutaneous melanoma". Paper presented in EACR 2025, 2025.
  2. Tomás, Ana; Maximino, José; Nunes, Hugo; Salvador, Rute; Luís, Rafael; Brito, Cheila; Diana P Saraiva; et al. "Identifying potential predictive and prognostic biomarkers in cutaneous melanoma". Paper presented in 1st NMS Research Week, 2023.
  3. Tomás, Ana; Maximino, José; Nunes, Hugo; Salvador, Rute; Luís, Rafael; Brito, Cheila; Diana P Saraiva; et al. "CCR4 high regulatory T cells and polarized monocytes as potential circulating biomarkers in cutaneous melanoma prognosis". Paper presented in 5th ASPIC International Congress, 2022.
  4. Saraiva, Inês; Chaves, Pedro; Brito, Cheila; Tomás, Ana; Maximino, José; Ferreira, Andreia; Farricha, Victor; et al. "Understanding the mechanism of ARL1 and ARL15 in the aggressiveness of cutaneous melanoma". Paper presented in 5th ASPIC International Congress, 2022.
  5. Tomás, Ana; Maximino, José; Nunes, Hugo; Salvador, Rute; Luís, Rafael; Brito, Cheila; Diana P Saraiva; et al. "Uncovering the immune profile of advanced cutaneous melanoma". Paper presented in XLVII Meeting of the Portuguese Society for Immunology, 2022.
  6. Tomás, Ana; Maximino, José; Nunes, Hugo; Luís, Rafael; Brito, Cheila; Saraiva, Diana; Salvador, Rute; et al. "Immune profiling in cutaneous melanoma: a prognostic and predictive tool". Paper presented in Cutaneous Melanoma: From Where to Where, 2021.
  7. Hipólito, Ana; Brito, Cheila; Tomás, Ana; Vicente, João B; Pojo, Marta; Serpa, Jacinta. "MST and EAAT3 are key players in the metabolic reliance on cysteine in BRD9-c.183G>C melanoma cells". Paper presented in Cutaneous Melanoma: From Where to Where, 2021.
  8. Tomás, Ana; Brito, Cheila; Azevedo, Ana; Esteves, Susana; Mafra, Manuela; Roque, Lúcia; Pojo, Marta. "PIK3CA activating mutations: from clinical impact in glioma molecular subgroups to targeted inhibition in glioma cell models". Paper presented in Cancer Biology: From Basic to Translational Research, LPCC-NRS, Webinar, 2020.
  9. Brito, Cheila; Azevedo, Ana; Tomás, Ana; Esteves, Susana; Martins, Carmo; Mafra, Manuela; Roque, Lúcia; Pojo, Marta. "Análise mutacional do gene PIK3CA nos subgrupos moleculares de glioma". Paper presented in 1º Encontro Nacional de Jovens Investigadores em Oncologia, Porto, 2019.
Journal article
  1. Tomás, Ana; Pojo, Marta. "PIK3CA Mutations: Are They a Relevant Target in Adult Diffuse Gliomas?". International Journal of Molecular Sciences 26 11 (2025): 5276. https://doi.org/10.3390/ijms26115276.
    Published • 10.3390/ijms26115276
  2. Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; et al. "BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2024): 166983. http://dx.doi.org/10.1016/j.bbadis.2023.166983.
    Published • 10.1016/j.bbadis.2023.166983
  3. Yang, Hongbing; Sun, Hong; Brackenridge, Simon; Zhuang, Xiaodong; Wing, Peter A C; Quastel, Max; Walters, Lucy; et al. "HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation". Science Immunology 8 84 (2023): http://dx.doi.org/10.1126/sciimmunol.abl8881.
    Published • 10.1126/sciimmunol.abl8881
  4. Cabaço, Luís C.; Tomás, Ana; Pojo, Marta; Barral, Duarte C.. "The Dark Side of Melanin Secretion in Cutaneous Melanoma Aggressiveness". Frontiers in Oncology 12 (2022): 887366. http://dx.doi.org/10.3389/fonc.2022.887366.
    Open access • Published • 10.3389/fonc.2022.887366
  5. Brito, Cheila; Tomás, Ana; Azevedo, Ana; Esteves, Susana; Mafra, Manuela; Roque, Lúcia; Pojo, Marta. "PIK3CA Mutations in Diffuse Gliomas: An Update on Molecular Stratification, Prognosis, Recurrence, and Aggressiveness". Clinical Medicine Insights: Oncology 16 (2022): 117955492110688. http://dx.doi.org/10.1177/11795549211068804.
    10.1177/11795549211068804
  6. Brito, Cheila; Tomás, Ana; Silva, Sandra; Bronze, Maria Rosário; Serra, Ana Teresa; Pojo, Marta. "The Impact of Olive Oil Compounds on the Metabolic Reprogramming of Cutaneous Melanoma Cell Models". Molecules 26 2 (2021): 289. http://dx.doi.org/10.3390/molecules26020289.
    Open access • Published • 10.3390/molecules26020289
Thesis / Dissertation
  1. Tomás, Ana. "Targeted inhibition of PIK3CA mutations in glioma cell models". Master, Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, 2021. http://hdl.handle.net/10362/114348.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/03/29 Biomarcadores imunes e mecanismos de agressividade no melanoma cutâneo 2º Encontro de Dermato-Oncologia do Algarve
Grupo HPA Saúde (Faro, Portugal)
2024/10/15 Identifying potential predictive and prognostic immune biomarkers in cutaneous melanoma NMS PhD Retreat
PhD Committee, NOVA Medical School (Lisbon, Portugal)
2024/07/05 Immunophenotyping in cutaneous melanoma patients uncovers potential prognostic and predictive biomarkers Encontros de Investigação - Dermatologia Oncológica
Instituto Português de Oncologia Francisco Gentil Lisboa (Lisboa, Portugal)
2024/04/19 Biologia Molecular no contexto do Melanoma Cutâneo 1ª Reunião do Grupo de Estudos do Melanoma & Cancro Cutâneo
Sociedade Portuguesa de Oncologia (Coimbra, Portugal)
2023/05/05 Clinical impact of CCR4high regulatory T cells and polarized monocytes in cutaneous melanoma Encontro de Investigação em Dermatologia Oncológica
Instituto Português de Oncologia de Lisboa Francisco Gentil (Lisbon, Portugal)
2021/10/15 Are TERT, PTEN, EGFR and MGMT additional biomarkers in glioma molecular classification? XII Congresso Nacional de Neuro-Oncologia
Associação Portuguesa de Neuro-Oncologia (Portugal)
2021/10/15 The effect of growth hormone therapy in patients with residual lesion of pediatric low-grade gliomas - In vitro and clinical data XII Congresso Nacional de Neuro-Oncologia
Associação Portuguesa de Neuro-Oncologia (Portugal)
2021/10/15 PIK3CA activating mutations: from clinical impact in glioma molecular subgroups to targeted inhibition in glioma cell models XII Congresso Nacional de Neuro-Oncologia
Associação Portuguesa de Neuro-Oncologia (Portugal)
2021/04/09 Immune microenvironment in melanoma: clinical impact of regulatory T cells and tumor-associated macrophages in prognosis and response to therapy VI Jornadas de Investigação em Oncologia em Portugal
Liga Portuguesa Contra o Cancro (Lisboa, Portugal)
2021/03/18 Targeted inhibition of PIK3CA mutations in glioma cell models Seminários UIPM
Instituto Português de Oncologia de Lisboa Francisco Gentil (Lisboa, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/10/28 - 2023/10/28 Attended the 1st Immuno-Oncology SPO-SPI Joint Meeting, at Conímbriga Hotel do Paço, Coimbra, Portugal
Meeting
 1st Immuno-Oncology SPO-SPI Joint Meeting
2023/04/14 - 2023/04/14 Attended the VIII Jornadas de Investigação em Oncologia em Portugal, in Lisbon, Portugal
Conference
 VIII Jornadas de Investigação em Oncologia em Portugal
Liga Portuguesa Contra o Cancro Núcleo Regional do Sul, Portugal
2020/09/24 - 2020/09/24 Attended the 2º Encontro Nacional de Jovens Investigadores em Oncologia, via webinar.
Meeting
 2º Encontro Nacional de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2020/02/28 - 2020/02/28 Attended the Encontros de Investigação - Genómica e Melanoma, at IPOLFG, Lisbon, Portugal, a conference about the importance of genomics in melanoma diagnosis, prognosis and treatment
Conference
 Encontros de Investigação - Genómica e Melanoma
2018/07/02 - 2018/07/04 Conference "Encontro com a Ciência e Tecnologia 2018", the biggest national reunion of researchers from all knowledge fields, in Lisbon (Centro de Congressos de Lisboa)
Conference
 Encontro com a Ciência e Tecnologia 2018
2015/03/24 - 2015/03/30 1-week English course at the Swan Training Institute, in Dublin, Ireland
Other
Swan English Language Training Institute, Ireland
Distinctions

Award

2024 Best Oral Presentation at NMS PhD Retreat
2023 Oral Communication
Encontros de Investigação em Dermatologia Oncológica - IPOLFG, Portugal
2023 Best Poster at the 1st NMS Research Week

Other distinction

2019 Merit Certificate
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 Merit Certificate
Escola Secundária José Saramago, Portugal