André Luz (8F16-5688-9F2C)

Curriculum Vitae

André Luz

André Luz completed the Bachelor’s Degree in Medicinal Chemistry in 2015 and the Master’s Degree in Medicinal Chemistry in 2017, both by the Faculty of Sciences and Technology of the University of Coimbra. During his Master’s Degree he did research on Luis Arnaut’s lab, where he developed skills in the areas of organic chemistry, photochemistry, cell-based assays and animal science, both theoretical and practical. The research culminated with the development of a scientific article and his master’s thesis, which was awarded with the Best Portuguese Master Thesis in Medicinal Chemistry prize. Currently André is enrolled in an FCT-funded PhD on Rui Moreira’s lab, in the Medicinal Chemistry group of the Research Institute for Medicines of the University of Lisbon, working in the synthesis and development of new antinecroptotic small molecules with potential application on CNS disorders. During his academic path he simultaneously participated in academic associations, was student representative during the bachelor’s degree, enrolled on entrepreneurship contests and co-founded and worked on a Junior Enterprise in the chemistry field.

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Identification

Personal identification

Full name: André Luz

Citation names

André F. S. Luz

Author identifiers

Ciência ID: 8F16-5688-9F2C
ORCID iD: 0000-0003-3611-4598

Email addresses

andrefluz@ff.ulisboa.pt (Professional)

Addresses

Avenida Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

https://www.linkedin.com/in/andrefsluz/ (Social media)

Knowledge fields

Exact Sciences - Chemical Sciences - Organic Chemistry
Exact Sciences - Chemical Sciences - Physical Chemistry
Natural sciences - Biological Sciences
Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)	Elementary (A2)	Intermediate (B1)	Intermediate (B1)

Education

	Degree	Classification
2017/11/15 - 2021/11/15 Ongoing	PhD in Chemistry (Doutoramento) Major in Specialization in Medicinal Chemistry Universidade de Coimbra Centro de Química de Coimbra, Portugal "Hit-to-lead optimization of novel RIPK1 inhibitors with anti-necroptotic activity" (THESIS/DISSERTATION)
2015/09/01 - 2017/09/30 Concluded	Master’s degree in Medicinal Chemistry (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "5,10,15,20-Tetrakis(2,6-difluoro-3-sulfonylphenyl)bacteriochlorin: from synthesis to the preclinical studies" (THESIS/DISSERTATION)	18/20
2016 - 2016 Concluded	Laboratory Animal Science Category C Course (FELASA accreditation) (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/08/01 - 2015/08/31 Concluded	Summer internship (Outros) Major in Neuroendocrinology and Aging Group Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/09/01 - 2015/07/31 Concluded	Bachelor's degree in Medicinal Chemistry (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal "LUZ10 suitable for therapy and diagnose: photochemical and photophysical characterization" (THESIS/DISSERTATION)	17/20
2014/09 - 2015/01 Concluded	English Course (B2 Level) (Outros) Universidade de Coimbra Faculdade de Letras, Portugal
2014/08/01 - 2014/08/30 Concluded	Summer Internship (Outros) Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2014/02 - 2014/06 Concluded	English Course (B1 Level) (Outros) Universidade de Coimbra Faculdade de Letras, Portugal

Affiliation

Science

	Category Host institution	Employer
2023/10/30 - Current	Researcher (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

	Category Host institution	Employer
2017/11/15 - 2023/10/31	Bolseiro de Doutoramento	Universidade de Lisboa Faculdade de Farmácia, Portugal

Outputs

Publications

Conference poster	Andre F. S. Luz; Andreia Sofia da Costa Vieira (8211-890B-78C6); Marques, Vanda; Aniceto, Natália; Rodrigues, CMP; Rita C. Guedes; Lígia Catarina Gomes da Silva (3B1B-F867-0C15); Moreira, Rui. "Novel Class of Necroptotic Cell Death Inhibitors: Synthetic Approach and In Vitro Assays". Paper presented in European Federation for Medicinal Chemistry – International Symposium on Medicinal Chemistry, 2021. Andre F. S. Luz; Andreia Sofia da Costa Vieira (8211-890B-78C6); Marques, Vanda; Aniceto, Natália; Rodrigues, CMP; Rita C. Guedes; Lígia Catarina Gomes da Silva (3B1B-F867-0C15); Moreira, Rui. "Targeting Necroptosis: Discovery and Optimization of Novel RIPK1 Inhibitors". Paper presented in European School of Medicinal Chemistry, 2021. Andre F. S. Luz; Andreia Sofia da Costa Vieira (8211-890B-78C6); Marques, Vanda; Rodrigues, CMP; Rita C. Guedes; Lígia Catarina Gomes da Silva (3B1B-F867-0C15); Moreira, Rui. "Synthesis and study of a novel class of potent necroptosis inhibitors - Different heterocycles, distinct affinities". Paper presented in 7th Portuguese Young Chemists Meeting, 2021. André F. S. Luz; Andreia Sofia da Costa Vieira (8211-890B-78C6); Rita C. Guedes; Lígia Catarina Gomes da Silva (3B1B-F867-0C15); Moreira, Rui. "Synthetic approaches to 3-substituted 1H-pyrazole-5-carbaldehydes as precursors for antinecroptotic inhibitors". Paper presented in XXVI Nacional Meeting of the Portuguese Society of Chemistry, 2019. André F. S. Luz; Rita C. Guedes; Moreira, Rui; Lígia Catarina Gomes da Silva (3B1B-F867-0C15). "Synthesis of 3-substituted 1H-pyrazole-5-carbaldehydes as precursors of necroptotic cell death inhibitors". Paper presented in 4th Colégio de Química of University of Lisbon Congress, 2019. André F. S. Luz; Schaberle, FA; Helder T. Soares; Lobo, Ana Catarina S. ; Arnaut, Luis G.. "LUZ10, a New Water-soluble Bacteriochlorin Photosensitizer: photochemical, in vitro and in vivo characterization". Paper presented in XXV Nacional Meeting of the Portuguese Society of Chemistry, 2017. André F. S. Luz; Schaberle, FA; Helder T. Soares; Pinto, Sara M. A.; Pereira, Mariette M.; Arnaut, Luis G.. "Synthesis and Characterisation of LUZ10, a Soluble Bacteriochlorin for Cancer Treatment". Paper presented in V National Chemistry Student's Meeting, 2017. André F. S. Luz; Schaberle, FA; Helder T. Soares; Arnaut, Luis G.. "Characterisation of LUZ10, a Soluble Bacteriochlorin for PDT Treatment". Paper presented in XXII Portuguese-Galician Chemistry Meeting, 2016. André F. S. Luz; Schaberle, FA; Helder T. Soares; Arnaut, Luis G.. "Photochemical and photophysical characterisation of a soluble bacteriochlorin for biomedical applications". Paper presented in IV National Chemistry Students Meeting, 2016.
Journal article	da Silva, Gustavo; André F. S. Luz; Duarte, Denise; Fontinha, Diana; Silva, Vera L. M.; Almeida Paz, Filipe A.; Madureira, Ana M.; et al. Corresponding author: da Silva, Gustavo. "Facile access to structurally diverse antimalarial indoles using a one-pot A3 coupling and domino cyclization approach". ChemMedChem (2023): http://dx.doi.org/10.1002/cmdc.202300264. 10.1002/cmdc.202300264 Luz, André F.S.; Pucelik, Barbara; Pereira, Mariette M.; Dabrowski, Janusz M.; Arnaut, Luis G.. "Translating phototherapeutic indices from in vitro to in vivo photodynamic therapy with bacteriochlorins". Lasers in Surgery and Medicine 50 5 (2018): 451-459. http://dx.doi.org/10.1002/lsm.22931. Published • 10.1002/lsm.22931
Thesis / Dissertation	Andre F. S. Luz. "5,10,15,20-Tetrakis(2,6-difluoro-3-sulfonylphenyl)bacteriochlorin: from synthesis to the preclinical studies". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2017. http://hdl.handle.net/10316/83243. Andre F. S. Luz. "LUZ10 suitable for therapy and diagnose: photochemical and photophysical characterization". Degree, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2015.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/06/26	Novel class of necroptotic cell death inhibitors: From family synthesis to lead compound study	14th iMed.ULisboa Meeting
2021/09/07	Novel Class of Necroptotic Cell Death Inhibitors: Synthetic Approach and In Vitro Assays	European Federation for Medicinal Chemistry – Young Medicinal Chemists’ Symposium
2021/04/26	Different Heterocycles, Distinct Affinities – Synthesis and Study of a Novel Class of Potent Necroptosis Inhibitors	XXIX European Colloquium on Heterocyclic Chemistry (France)
2017/06/08	Synthesis and Characterisation of a water soluble bacteriochlorin photosensitizer	XVI International Photodynamic Association World Congress International Photodynamic Association (Coimbra, Portugal)
2016	Characterisation of a Soluble Bacteriochlorin for Cancer Treatment	II NEQ/AAC’s Scientific Meeting NEQ/AAC (Coimbra, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2020/12 - 2022/12	MSc Student's Lab supervision Co-supervisor	Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2017/01 - 2017/06/13	XVI International Photodynamic Association World Congress (2017/06/08 - 2017/06/13) Congress (Co-organisor)	International Photodynamic Association, Portugal Universidade de Coimbra, Portugal
2016/06 - 2017/04/10	V National Chemistry Students Meeting (2017/04/07 - 2017/04/10) Congress (Co-organisor)	Universidade de Coimbra Departamento de Química, Portugal
2016/01 - 2016/03	III Job and Entrepreneurship Fair of the Department of Chemistry of University of Coimbra (2016/02/25 - 2016/02/26) Congress (Co-organisor)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/01/01 - 2015/02/25	II Job and Entrepreneurship Fair of the Department of Chemistry of University of Coimbra (2015/02/25 - 2015/02/25) Congress	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/01/01 - 2014/05/01	4th Portuguese Young Chemist Meeting (2014/04/29 - 2014/05/01) Congress (Co-organisor)	Universidade de Coimbra, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2019/07/24 - 2019/07/26	XXVI Nacional Meeting of the Portuguese Society of Chemistry Congress	XXVI Nacional Meeting of the Portuguese Society of Chemistry Sociedade Portuguesa de Química, Portugal
2018/04/10 - 2018/04/10	Académica Start UC - "A Química do Empreendedorismo" Conference	A Química do Empreendedorismo - Académica Start UC Universidade de Coimbra, Portugal
2017/07/16 - 2017/07/19	XXV Nacional Meeting of the Portuguese Society of Chemistry Congress	XXV Nacional Meeting of the Portuguese Society of Chemistry Sociedade Portuguesa de Química, Portugal
2016/11/09 - 2016/11/11	XXII Portuguese-Galician Chemistry Meeting Congress	XXII Portuguese-Galician Chemistry Meeting Sociedade Portuguesa de Química, Portugal
2016/03/18 - 2016/03/20	IV National Chemistry Students Meeting Congress	IV National Chemistry Students Meeting Universidade do Porto, Portugal
2015/01 - 2015/12	Poliempreende – Entrepreneurship Contest Workshop	Poliempreende – Entrepreneurship Contest Instituto Politécnico de Coimbra, Portugal
2014/01 - 2015/12	Representative of the Chemistry and Medicinal Chemistry Bachelor’s students for the Commission of Queima das Fitas Festival	Queima das Fitas Universidade de Coimbra, Portugal
2013 - 2015	Representative of the bachelor’s degree in Medicinal Chemistry before the Pedagogical Council of the Faculty of Sciences and Technology of the University of Coimbra Round table	Pedagogical Council of the Faculty of Sciences and Technology of the University of Coimbra Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Association member

	Society Organization name	Role
2017/01 - Current	Molecular Junior Enterprise	Co-founder and Chief Operating Officer
2019/01 - 2020/01	Molecular Junior Enterprise Lisbon	Co-founder and Chief Executive Officer
2015/01 - 2017/12	National Chemistry Students Association	2015 - Committee’s Substitute; 2016 - Treasurer; 2017 – Chairman
2015/01 - 2015/12	Chemistry Students' Association of University of Coimbra	Coordinator of the division for career opportunities
2013/01 - 2015/12	Chemistry Students' Association of University of Coimbra	2013/2014 - Collaborator; 2015 - Coordinator of the division for career opportunities

Committee member

	Activity description Role	Institution / Organization
2020/05 - 2022/03	Toastmasters international - Public speaking club Member	Toastmasters International, Portugal

Conference scientific committee

	Conference name	Conference host
2015/11/19 - 2015/11/20	I NEQ/AAC’s Scientific Meeting	Chemistry student’s association of University of Coimbra

Scientific expedition

	Activity description	Institution / Organization
2022/04 - 2022/06	Visiting PhD Student	Imperial College London, United Kingdom
2018/05 - 2018/05	Visiting PhD Student	Université de Genève, Switzerland

Distinctions

Award

2021	Best PhD Student Oral Communication Prize XXIX European Colloquium on Heterocyclic Chemistry, France
2021	Best Poster Communication Award Sociedade Portuguesa de Química, Portugal
2021	Best Poster Communication Award European School of Medicinal Chemistry , Italy
2018	Best Portuguese Master Thesis in Medicinal Chemistry Sociedade Portuguesa de Química, Portugal
2017	Best pitch on Angelini University Award (Entrepreneurship Competition) Angelini Farmacêutica Lda, Portugal
2015	Winner of Bioempreende (Entrepreneurship Competition) Núcleo de Estudantes de Bioquímica da Associação Académica de Coimbra, Portugal
2015	Top 3% of Students Universidade de Coimbra, Portugal
2014	Top 3% of Students Universidade de Coimbra, Portugal

Other distinction

2022	EMBO Scientific Exchange Grant EMBO, Germany
2021	Fellowship Winner for the 40th European School of Medicinal Chemistry European School of Medicinal Chemistry , Italy