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Identification

Personal identification

Full name
Silvia Filipa Camoeira Gonçalves de Carvalho

Citation names

  • Carvalho, Silvia
  • Carvalho, Sílvia

Author identifiers

Ciência ID
8F13-7782-254E
ORCID iD
0000-0001-6436-205X

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Exact Sciences - Computer and Information Sciences - Bioinformatics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Elementary (A2) Beginner (A1) Elementary (A2) Elementary (A2)
German Beginner (A1) Elementary (A2) Elementary (A2) Elementary (A2) Beginner (A1)
Education
Degree Classification
2018/01/01 - 2022/12/31
Ongoing
 Biologia Básica e Aplicada (Doutoramento)
Major in Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Decoding functional associations of genome organization within the 3D nuclear space" (THESIS/DISSERTATION)
2016/10/01 - 2017/04/30
Attended
 Bioinformática e Biologia Computacional (Mestrado integrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/09/01 - 2012/09/01
Concluded
 Biologia Molecular e Genética (Mestrado integrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"The role of SETD2 in transcription and in DNA damage response" (THESIS/DISSERTATION)
 19
2009/09/01 - 2010/09/01
Attended
 Antropologia (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências Sociais e Humanas, Portugal
2005/09/01 - 2009/09/01
Concluded
 Análises Clínicas e de Saúde Pública (Licenciatura)
Instituto Politécnico de Lisboa, Portugal
"Estudo de biomarcadores de pré-eclâmpsia" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2018/10/01 - Current Researcher (Research) Max Delbrück Centrum für Molekulare Medizin Experimental and Clinical Research Center, Germany
2018/10/01 - Current Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2010/01/01 - 2017/12/31 Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2008/09/15 - 2009/09/15 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Other Careers

Category
Host institution 		Employer
2009/09/01 - 2010/01/31 Técnico de 2ª Classe (Técnico de Diagnóstico e Terapêutica - Técnico de Análises Clínicas e de Saúde Pública) GenoMed, Diagnósticos de Medicina Molecular , Portugal
2008/07/01 - 2008/09/30 Técnico de 2ª Classe (Técnico de Diagnóstico e Terapêutica - Técnico de Análises Clínicas e de Saúde Pública) Centro de Patologia Clínica de Alhandra, Portugal
Outputs

Publications

Journal article
  1. Winick-Ng, Warren; Kukalev, Alexander; Harabula, Izabela; Zea-Redondo, Luna; Szabó, Dominik; Meijer, Mandy; Serebreni, Leonid; et al. "Cell-type specialization is encoded by specific chromatin topologies". Nature 599 7886 (2021): 684-691. http://dx.doi.org/10.1038/s41586-021-04081-2.
    10.1038/s41586-021-04081-2
  2. Sridhara, Sreerama Chaitanya; Carvalho, Sílvia; Grosso, Ana Rita; Gallego-Paez, Lina Marcela; Carmo-Fonseca, Maria; de Almeida, Sérgio Fernandes. "Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation". Cell Reports 18 2 (2017): 334-343. http://dx.doi.org/10.1016/j.celrep.2016.12.050.
    10.1016/j.celrep.2016.12.050
  3. Posa, Ioana; Carvalho, Silvia; Tavares, Joana; Grosso, Ana Rita. "A pan-cancer analysis of MYC-PVT1 reveals CNV-unmediated deregulation and poor prognosis in renal carcinoma". Oncotarget 7 30 (2016): 47033-47041. http://dx.doi.org/10.18632/oncotarget.9487.
    10.18632/oncotarget.9487
  4. Grosso AR; Leite AP; Carvalho S; Matos MR; Martins FB; Vítor AC; Desterro JM; Carmo-Fonseca M; de Almeida SF. "Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma.". eLife (2015): http://europepmc.org/abstract/med/26575290.
    10.7554/elife.09214
  5. Carvalho S; Vítor AC; Sridhara SC; Martins FB; Raposo AC; Desterro JM; Ferreira J; de Almeida SF. "SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.". eLife (2014): http://europepmc.org/abstract/med/24843002.
    10.7554/elife.02482
  6. Carvalho S; Raposo AC; Martins FB; Grosso AR; Sridhara SC; Rino J; Carmo-Fonseca M; de Almeida SF. "Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription.". Nucleic acids research (2013): http://europepmc.org/abstract/med/23325844.
    10.1093/nar/gks1472
  7. de Almeida SF; Grosso AR; Koch F; Fenouil R; Carvalho S; Andrade J; Levezinho H; et al. "Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.". Nature structural & molecular biology (2011): http://europepmc.org/abstract/med/21792193.
    10.1038/nsmb.2123
Thesis / Dissertation
  1. Carvalho, Sílvia Filipa Camoeira Gonçalves de, 1986-. "The role of SETD2 in transcription and in DNA damage response". Master, 2012. http://hdl.handle.net/10451/8410.

Other

Other output
  1. DNA damage independent inhibition of NF-kB transcription by anthracyclines. 2020. Chora, Â.F.; Pedroso, D.; Kyriakou, E.; Pejanovic, N.; Colaço, H.; Gozzelino, R.; Barros, A.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125158708&partnerID=MN8TOARS.
    10.1101/2020.04.27.065003
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/02/08 - 2021/09/30 The role of Srrm2 in stemness
Supervisor
 Science in molecular Medicine (Master)
Charité - Universitätsmedizin Berlin Institut für Medizin- Pflegepädagogik und Pflegewissenschaft, Germany
2020/09/14 - 2020/12/14 The role of super-enhancers in the three-dimensional genomic topology within the nuclear environment
Co-supervisor
 Medical Biotechnology (Master)
Technische Universität Berlin, Germany

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021/11/26 - Current Journal of biological Methods
2020/12/12 - Current Nucleic Acids Research
2020/09/01 - Current Cell
2020/03/10 - Current Nature Biotechnology
2020/02/01 - Current Molecular Cell
2019/06 - Current Science

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/04 - 2022/02/04 A virtual visit to Ana Pombo's lab: Career in science round table Biology and Biophysics (Bachelor) Humboldt-Universität zu Berlin, Germany
2019/12/08 - 2019/12/13 Berlin Basics Training Camp - Visualisation of protein localisation in the nucleus by cryo-immunofluorescence (Doktor (PhD)) Humboldt-Universität zu Berlin, Germany

Mentoring / Tutoring

Topic Student name
2019/10/01 - 2019/11/30 Research internship title of Minerva sutdent Blerim Jashari
2019/10/01 - 2019/11/30 Research internship title of Minerva sutdent Dulce Riviera
Distinctions

Award

2015 Best molecular research
Sociedade Portuguesa de Genética Humana, Portugal
2011 Pfizer award
Pfizer Portugal, Portugal

Other distinction

2019 Travel grant Image Analysis for Biologist - ZIDAS course
ScopeM-IDA, Switzerland
2018 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal