???global.info.a_carregar???
Adelaide Sousa is a PhD Researcher specializing in Pharmaceutical Sciences. She recently completed her PhD in Pharmaceutical Sciences, with a focus on Medicinal and Pharmaceutical Chemistry, at the Faculty of Pharmacy, University of Porto, in 2024. This achievement was part of a FCT-funded fellowship under the International Year of the Periodic Table initiative. Prior to this, she earned her Master’s degree in Quality Control, specializing in Drugs and Medicinal Plants, also from the Faculty of Pharmacy, in 2019. Adelaide completed her Bachelor’s degree in Biochemistry at the Faculty of Sciences, University of Porto, in 2017. Her research contributions are extensive, with 14 peer-reviewed journal articles published, 2 book chapters authored, and 1 commentary. Her work has garnered over 170 citations and an h-index of 6 (Scopus). Adelaide has actively engaged in the dissemination of scientific knowledge, presenting 11 oral communications and 20 posters at both national and international conferences. Furthermore, she has contributed to 3 research projects funded by the Foundation for Science and Technology (FCT) and supervised 4 students at both the Bachelor's and Master's levels. Some of the current research interests include natural products, medicinal chemistry, diabetes mellitus, inflammation and nanotechnology. Her expertise encompasses advanced techniques such as flow cytometry, ELISA, enzymatic assays, cell culture and microscopy.
Read full resume ↓
Identification

Personal identification

Full name
Adelaide Patrícia Teles de Sousa

Citation names

  • Sousa, Adelaide

Author identifiers

Ciência ID
8E1F-F6D4-F1E0
ORCID iD
0000-0002-5393-8161

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Natural sciences - Biological Sciences
  • Natural sciences - Biological Sciences - Other Biological Topics
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Portuguese (Mother tongue)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2020/07/02 - 2024/07/02
Concluded
 Pharmaceutical Sciences (Doutoramento)
Major in Pharmaceutical and Medicinal Chemistry
Universidade do Porto Faculdade de Farmácia, Portugal
"Exploring the adverse effects of silver nanoparticles onintestinal health: unveiling the pro-inflammatory mechanisms andprotective strategies with quercetin, using in vitro and in vivo models" (THESIS/DISSERTATION)
 Unanimously approved
2023/09/01 - 2023/09/30
Concluded
 Development and Establishment of a Healthy Intestinal Co-Culture Model for Exploring the Effects of Silver Nanoparticles and Quercetin (Outros)
Major in Pharmaceutical Sciences
IUF - Leibniz-Institut für umweltmedizinische Forschung GmbH, Germany
 Approved
2021/09/06 - 2021/09/17
Concluded
 FELASA A, B, D (Outros)
Major in Advanced Laboratory Animal Science Course: FELASA accredited Course for functions A, B and D (mouse, rat, zebrafish and fish species-specific) aligned with the European Directive 2010/63
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Approved
2017/09 - 2019/11
Concluded
 Quality Control (Mestrado)
Major in Drugs and Medicinal Plants
Universidade do Porto Faculdade de Farmácia, Portugal
"Chalcones targeting neutrophils for the modulation of oxidative stress in Diabetes mellitus" (THESIS/DISSERTATION)
 19
2014/09 - 2017/07
Concluded
 Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Inibição da enzima alfa-glicosidase por flavonoides" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2019/12/10 - 2020/02/10 Contracted Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2019/08/08 - 2019/12/01 Contracted Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2020/07/02 - 2024/07/02 PhD Studentship (SFRH/BD/150656/2020) Fundação para a Ciência e a Tecnologia, Portugal
REQUIMTE LAQV Porto, Portugal
Projects

Grant

Designation Funders
2019/08/08 - 2019/12/01 Carotenoid oxidation by reactive oxygen and nitrogen species: chemical analysis and biological activity
PTDC/QEQ-QAN/1742/2014
Research Fellow
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/12/01 - 2022/11/30 Desenvolvimento de novos inibidores do osteossarcoma invasivo baseados em derivados da fisetina
PTDC/MED-QUI/29243/2017
Researcher
Universidade de Aveiro, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/06/01 - 2021/12/31 Use of flavonoids in the prophylaxis of intestinal pro-inflammatory effects of silver nanoparticles
PTDC/NAN-MAT/29248/2017
Researcher
Universidade do Porto, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UID/QUI/50006/2019
LA/P/0008/2020
10.54499/LA/P/0008/2020
Researcher
Universidade do Porto Faculdade de Ciências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade de Aveiro, Portugal

Universidade de Évora, Portugal

Unidade de Investigação Vidro e Cerâmica para as Artes, Portugal

Universidade de Lisboa Instituto Dom Luiz, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2020/07/02 - 2021/12/31 Uso de flavonoides na profilaxia dos efeitos pro-inflamatórios intestinais de nanopartículas de prata
PTDC/NAN-MAT/29248/2017
Researcher
Outputs

Publications

Book chapter
  1. Sousa, Adelaide; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. "Applications of Silver Nanoparticles in Daily Life". In Applications of Silver Nanoparticles, 51-179. Nova Science Publishers, 2023.
    Published
  2. Sousa, Adelaide; Ribeiro, Daniela (F915-6D0F-B6EB); Fernandes, Eduarda; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Silver nanoparticles: An approach to their synthesis, characterization and biological activities". In Advances in Nanotechnology. United States: Nova Science Publishers, 2022.
    Published
Conference abstract
  1. Sousa, Adelaide; Rufino, Ana T.; Ramalho, Ana; Carvalho, Félix; Fernandes, Eduarda. "Silver nanoparticles induce an inflammatory response of intestinal C2BBe1 cells". Paper presented in SOT 62nd Annual Meeting and ToxExpo, 2023.
  2. Sousa, Adelaide; Ramalho, Ana; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. Corresponding author: Fernandes, Eduarda. "Polyvinylpyrrolidone-Coated Silver Nanoparticles Induce the Expression of Inducible Nitric Oxide Synthase in Intestinal C2BBe1 Cells". 2022.
    10.3390/ecmc2022-13196
  3. Sousa, Adelaide; Rufino, Ana T.; Fernandes, Eduarda; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Silver Nanoparticles Exert Harmful Effects in Human Monocytes". Paper presented in 14th Edition of the Nacional Organic Chemistry Meeting and 7th Edition of the Nacional Therapeutic Chemistry Meeting, 2022.
    Published
  4. Sousa, Adelaide; Rufino, Ana T; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. Corresponding author: Fernandes, Eduarda. "Size and Coating-Dependent Toxicity and Pro-inflammatory Effects of Silver Nanoparticles in Human Monocytes and Macrophages". Paper presented in SOT 61st Annual Meeting and ToxExpo, 2022.
  5. Freitas, Marisa (presenter); Sousa, Adelaide; Ribeiro, Daniela; Fernandes, Eduarda. "Prediction of anti-diabetic activity of flavonoids targeting a-glucosidase". Paper presented in 22nd International Conference on Prevention of diabetes and complications [Pancreat. Disord. Ther., 7 (4) (Suppl) (2017) 25], London, 2017.
    Published • 10.4172/2165-7092-c1-008
Conference paper
  1. Sousa, Adelaide; Azevedo, Rui; Oliveira, Sara; Preguiça, Inês; Viana, Sofia; Reis, Flávio; Almeida, Agostinho; et al. Corresponding author: Fernandes, Eduarda. "Biodistribution and cytokine production following oral administration of silver nanoparticles to C57BL/6J mice"". Paper presented in SOT XVIth International Congress of Toxicology (ICT 2022), 2022.
Conference poster
  1. Sousa, Adelaide; Rufino, Ana T.; Ramalho, Ana; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. "Silver nanoparticles induce an inflammatory response of intestinal C2BBe1 cells". Paper presented in 62nd Annual Meeting & ToxExpo; Nashville, Tennessee, USA, 2023.
  2. Sousa, Adelaide; Azevedo, Rui; Costa, V. M.; Oliveira, S.; Preguiça, I.; Viana, S.; Reis, F.; et al. "Impact of dietary exposure to silver nanoparticles on the intestinal inflammatory response in C57BL/6J mice". Paper presented in 12th International Symposium on Biological Monitoring in Occupational and Environmental Health, 2023.
  3. Sousa, Adelaide; Lei, Ana; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. "Polyvinylpyrrolidone-coated silver nanoparticles induce the expression inducible nitric oxide synthase in intestinal C2BBe1 cells". Paper presented in ECMC – The 8th International Electronic Conference on Medicinal Chemistry, 2022.
  4. Sousa, Adelaide; Azevedo, Rui; Oliveira, Sara; Preguiça, Inês; Viana, Sofia; Reis, Flávio; Almeida, Agostinho; et al. "Biodistribution and cytokine production following oral administration of silver nanoparticles to C57BL/6J mice". Paper presented in ICT - The XVIth International Congress of Toxicology, Maastricht, The Netherlands, 2022.
  5. Silva, Jorge; Sousa, Adelaide; Fernandes, Eduarda; Freitas, Marisa. "Flavonoids Hinder Human Neutrophils’ Oxidative Burst Induced by Silver Nanoparticles". Paper presented in Young Researchers Meeting, Porto, Portugal, 2022.
  6. Rufino, Ana Teresa; Ramalho, Ana; Sousa, Adelaide; Ferreira de Oliveira, José Miguel P.; Freitas, Paulo; Gómez, Manuel A. Gonzalez; Piñeiro-Redondo, Yolanda; et al. "Evaluation of cytotoxic and pro-inflammatory effects of silver nanoparticles in gastrointestinal tract in vitro models: Potential protective effect of flavonoids". Paper presented in 14.º Encontro Nacional de Química Orgânica (14ENQO) e 7.º Encontro Nacional de Química Terapêutica (7ENQT), 2022.
  7. Sousa, Adelaide; Rufino, Ana T; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. "Size and coating-dependent toxicity and pro-inflammatory effects of silver nanoparticles in human monocytes and macrophages". Paper presented in 61st Annual Meeting & ToxExpo, San Diego, California, 2022.
  8. Sousa, Adelaide; Ana T. Rufino; Daniela Ribeiro; Eduarda Fernandes; Freitas, Marisa. "Cytotoxic potential of silver nanoparticles to human neutrophils and human monocytes". Paper presented in SINFONIA- Safety in Nanomaterials and Nanotechnology, 2021.
  9. Jorge Silva; Sousa, Adelaide; Eduarda Fernandes; Freitas, Marisa. "Flavonoides como moduladores do burst oxidativo induzido por nanopartículas de prata em neutrófilos humanos". Paper presented in Encontro Nacional de Estudantes de Bioquímica, 2021, 2021.
  10. Sousa, Adelaide; Lucas, Mariana; Fernandes, Eduarda; Freitas, Marisa. "Comparison of AgNPs toxicity in human monocytes and macrophages". Paper presented in Comparison of AgNPs toxicity in human monocytes and macrophages, 2021.
  11. Sousa, Adelaide; Ribeiro, Daniela (F915-6D0F-B6EB); Correia, Catarina M.; Silva. Vera L. M.; Silva, Artur M. S.; Fernandes, Eduarda; Freitas, Marisa. "The protective effect of chalcones against human neutrophils’ oxidative burst and NETosis under hyperglycemic conditions". Paper presented in IberPhenol International Conference, 2020.
  12. Ana T. Rufino; Sousa, Adelaide; José Miguel P. Ferreira de Oliveira; Ribeiro, Daniela (F915-6D0F-B6EB); Manuel Gónzalez-Gómez; José Rivas; Paulo Freitas; Eduarda Fernandes; Marisa Freitas. "In vitro protective effect of flavonoids against intestinal toxicity of silver nanoparticles". Paper presented in IberPhenol International Conference, 2020.
  13. Freitas, Marisa; Sousa, Adelaide; Soares, Tânia; Ribeiro, Daniela (F915-6D0F-B6EB); Carvalho, Félix; Fernandes, Eduarda. "The role of calcium in silver nanoparticles-induced human neutrophils’ oxidative burst". Paper presented in SOT 59th Annual Meeting, 2020.
  14. Martins, Thaise; Sousa, Adelaide; Freitas, Marisa; Correia, Catarina M.; Silva, Vera L. M.; Lima, José L. F. C.; Fernandes, Eduarda; et al. "Modulation of human neutrophils’ oxidative burst by 2’-hydroxychalcone derivatives". Paper presented in Medicinal Chemistry Frontiers 2019, 2019.
  15. Fernandes, Eduarda; Rufino, Ana; Ferreira de Oliveira, Miguel; Ribeiro, Daniela; Sousa, Adelaide; Soares, Tânia; Gónzalez-Gómez, M.; et al. "Testing the Effects of Silver Nanoparticles in In Vitro Models of Intestinal Toxicity and Inflammation". Paper presented in 10th International Conference “Biomaterials and Nanobiomaterials: Recent Advances Safety-Toxicology and Ecological Issus”, 2019.
  16. Sousa, Adelaide; Martins, Thaise; Correia, Catarina M.; Silva, Vera L. M.; Lima, José L. F. C.; Ribeiro, Daniela (F915-6D0F-B6EB); Freitas, Marisa; et al. "Impact of chlacones on reactive species production by human neutrophils in hyperglycaemia conditions". Paper presented in EuroFoodChem XX Conference, 2019.
  17. Sousa, Adelaide; Freitas, Marisa; Fernandes, Eduarda; Adelaide Sousa; Eduarda Fernandes; Marisa Freitas. "Flavonoids are promising modulators of diabetes mellitus through the inhibition of a-glucosidase". Paper presented in 12th Edition of the University of Porto Youth Research Meeting (IJUP), 2018.
  18. Sousa, Adelaide; Rocha, Sílvia; Freitas, Marisa; Ribeiro, Daniela; Fernandes, Eduarda. "Effect of ß-carotene and its oxidation products in the oxidative burst of human neutrophils". Paper presented in XXIII Encontro Galego Portugués de Química, 2017.
  19. Ribeiro, Daniela; Sousa, Adelaide; Rocha, Silvia; Freitas, Marisa; Fernandes, Eduarda; Rocha, Sílvia. "ß-carotene and its biological oxidation products: are they good modulators of pro-oxidant reactive species in human blood and neutrophils assay system?". Paper presented in Meeting of the International HNE-Club and the University of Graz, 2017.
  20. Sousa, Adelaide; Freitas, Marisa; Fernandes, Eduarda. "Optimization of a micro-analysis assay for a-glucosidase activity". Paper presented in 10th Edition of the University of Porto Youth Research Meeting, 2017.
Journal article
  1. Sousa, Adelaide; Amaro, Andreia; Costa, Vera Marisa; Azevedo, Rui; Oliveira, Sara; Viana, Sofia; Reis, Flávio; et al. "Exploring quercetin’s protective potential against the pro-inflammatory effects of silver nanoparticles in C57BL/6J mice". Food and Chemical Toxicology (2024): 115081. http://dx.doi.org/10.1016/j.fct.2024.115081.
    10.1016/j.fct.2024.115081
  2. Sousa, Adelaide; Rocha, Sónia; Santos, Inês; Fernandes, Rui; Pacheco, Sofia; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Quercetin mitigates pro-inflammatory effects of polyvinylpyrrolidone (PVP)-coated silver nanoparticles on human intestinal epithelial cells". Toxicology (2024):
    Submitted
  3. Sousa, Adelaide; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. "Quercetin protective potential against nanoparticle-induced adverse effects". Nanotoxicology (2024):
    Under revision
  4. Sousa, Adelaide; Kämpfer, Angela A; Schins, Roel P.F.; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. Corresponding author: Fernandes, Eduarda. "Protective effects of quercetin on intestinal barrier and cellular viability against silver nanoparticle exposure: insights from an intestinal co-culture model". Nanotoxicology (2024):
    Under revision
  5. Sousa, Adelaide; Azevedo, Rui; Costa, Vera Marisa; Oliveira, Sara; Preguiça, Inês; Viana, Sofia; Reis, Flávio; et al. Corresponding author: Freitas, Marisa. "Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice". Archives of Toxicology 97 10 (2023): 2643-2657. http://dx.doi.org/10.1007/s00204-023-03558-5.
    10.1007/s00204-023-03558-5
  6. Ramalho, Ana; Sousa, Adelaide; Fernandes, Eduarda; Freitas, Marisa. Corresponding author: Freitas, Marisa. "O Burst Oxidativo Dos Neutrófilos Humanos Na Defesa Imune Inata: Uma Análise Detalhada Do Seu Papel Vital No Organismo". Revista Portuguesa de Ciências e Saúde 4 1 (2023): 72-97.
    Open access • Published
  7. Sousa, Adelaide; Rufino, Ana T.; Fernandes, Rui; Malheiro, Ana; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Silver nanoparticles exert toxic effects in human monocytes and macrophages associated with the disruption of mitochondrial membrane potential and release of pro-inflammatory cytokines". Archives of Toxicology 97 2 (2022): 405-420. http://dx.doi.org/10.1007/s00204-022-03415-x.
    10.1007/s00204-022-03415-x
  8. Sousa, Adelaide; Ramalho, Ana; Fernandes, Eduarda; Freitas, Marisa. "Nanopartículas de prata: história, benefícios e aplicações". Revista de Ciência Elementar 10 3 (2022): http://dx.doi.org/10.24927/rce2022.040.
    Published • 10.24927/rce2022.040
  9. Sousa, Adelaide; Azevedo, R.; Oliveira, S.; Preguiça, I.; Viana, S.; Reis, F.; Almeida, A.; et al. "P10-11 Biodistribution and cytokine production following oral administration of silver nanoparticles to C57BL/6J mice". Toxicology Letters 368 (2022): S159. http://dx.doi.org/10.1016/j.toxlet.2022.07.442.
    10.1016/j.toxlet.2022.07.442
  10. Sousa, Adelaide; Bradshaw, Tracey D.; Ribeiro, Daniela; Fernandes, Eduarda; Freitas, Marisa. "Pro-inflammatory effects of silver nanoparticles in the intestine". Archives of Toxicology 96 6 (2022): 1551-1571. http://dx.doi.org/10.1007/s00204-022-03270-w.
    10.1007/s00204-022-03270-w
  11. Rufino, Ana; Ramalho, Ana; Sousa, Adelaide; Ferreira de Oliveira, José; Freitas, Paulo; Gómez, Manuel; Piñeiro-Redondo, Yolanda; et al. "Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles". Molecules 26 21 (2021): 6610. http://dx.doi.org/10.3390/molecules26216610.
    Published • 10.3390/molecules26216610
  12. Sousa, Adelaide; Ribeiro, Daniela; Fernandes, Eduarda; Freitas, Marisa. "The Effect of Chalcones on the Main Sources of Reactive Species Production: Possible Therapeutic Implications in Diabetes Mellitus". Current Medicinal Chemistry 28 8 (2021): 1625-1669. http://dx.doi.org/10.2174/0929867327666200525010007.
    10.2174/0929867327666200525010007
  13. Sousa, Adelaide; Lucas, Mariana; Ribeiro, Daniela; Correia, Catarina M.; Silva, Vera L. M.; Silva, Artur M. S.; Fernandes, Eduarda; Freitas, Marisa. "Chalcones as Modulators of Neutrophil Oxidative Burst under Physiological and High Glucose Conditions". Journal of Natural Products 83 10 (2020): 3131-3140. http://dx.doi.org/10.1021/acs.jnatprod.0c00728.
    Published • 10.1021/acs.jnatprod.0c00728
  14. Ribeiro, Daniela; Sousa, Adelaide; Nicola, Pedro; Ferreira de Oliveira, José Miguel P.; Rufino, Ana T.; Silva, Marta; Freitas, Marisa; Carvalho, Félix; Fernandes, Eduarda. "ß-Carotene and its physiological metabolites: Effects on oxidative status regulation and genotoxicity in in vitro models". Food and Chemical Toxicology 141 (2020): 111392. http://dx.doi.org/10.1016/j.fct.2020.111392.
    Published • 10.1016/j.fct.2020.111392
  15. Freitas, Marisa; Lucas, Mariana; Sousa, Adelaide; Soares, Tânia; Ribeiro, Daniela; Carvalho, Félix; Fernandes, Eduarda. "Small-size silver nanoparticles stimulate neutrophil oxidative burst through an increase of intracellular calcium levels". World Academy of Sciences Journal (2020): http://dx.doi.org/10.3892/wasj.2020.46.
    10.3892/wasj.2020.46
  16. Ribeiro, Daniela; Sousa, Adelaide; Nicola, Pedro; Ferreira de Oliveira, Jose Miguel P.; Rufino, Ana T.; Silva, Marta; Freitas, Marisa; Carvalho, Felix; Fernandes, Eduarda. "beta-Carotene and its physiological metabolites: Effects on oxidative status regulation and genotoxicity in in vitro models". Food and Chemical Toxicology (2020): https://publons.com/publon/33324092/.
    10.1016/J.FCT.2020.111392
  17. Rocha, Sónia; Sousa, Adelaide; Ribeiro, Daniela; Correia, Catarina M.; Silva, Vera L. M.; Santos, Clementina M. M.; Silva, Artur M. S.; et al. "Correction: A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by chalcone derivatives". Food & Function 10 9 (2019): 6203-6203. http://dx.doi.org/10.1039/c9fo90045d.
    10.1039/c9fo90045d
  18. Rocha, Sónia; Sousa, Adelaide; Ribeiro, Daniela; Correia, Catarina M.; Silva, Vera L. M.; Santos, Clementina M. M.; Silva, Artur M. S.; et al. "A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by chalcone derivatives". Food & Function 10 9 (2019): 5510-5520. http://dx.doi.org/10.1039/c9fo01298b.
    10.1039/c9fo01298b
  19. Ribeiro, Daniela; Sousa, Adelaide; Rocha, Sílvia; Freitas, Marisa; Fernandes, Eduarda. "ß-Carotene and its biological oxidation products: are they good modulators of pro-oxidant reactive species in human blood and neutrophils assay systems?". Free Radical Biology and Medicine 124 (2018): 574-575. http://dx.doi.org/10.1016/j.freeradbiomed.2018.05.053.
    10.1016/j.freeradbiomed.2018.05.053
Manual
  1. Sousa, Adelaide. Participation in an interview for a chapter in the Ágora 11th grade philosophy textbook, titled “O investigador procura sempre contribuir para o progresso da ciência”. Porto, Portugal: Porto Editora. 2022.
    Published
Newsletter article
  1. Sousa, Adelaide; Rufino, Ana T.; Ana Ramalho; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa. "Intestinal inflammation mediated by silver nanoparticles is prevented by dietary flavonoids", Atlas of Science, 2022, https://atlasofscience.org/intestinal-inflammation-mediated-by-silver-nanoparticles-is-prevented-by-dietary-flavonoids/.
Thesis / Dissertation
  1. "Exploring the adverse effects of silver nanoparticles on intestinal health: unveiling the pro-inflammatory mechanisms and protective strategies with quercetin, using in vitro and in vivo models". PhD, Universidade do Porto Faculdade de Farmácia, 2024. https://hdl.handle.net/10216/161170.
  2. Sousa, Adelaide. "Chalcones targeting neutrophils for the modulation of oxidative stress in physiological and hyperglycemic conditions. Potential application in the treatment of diabetes mellitus". Master, Universidade do Porto Faculdade de Farmácia, 2019. https://hdl.handle.net/10216/124455.
  3. Sousa, Adelaide. "“Inhibition of alpha-glucosidase enzyme by flavonoids”". Degree, Universidade do Porto Faculdade de Ciências, 2017.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05 Quercetin attenuates silver nanoparticle-induced toxicity in intestinal cells 17th Young Researchers Meeting
(Porto, Portugal)
2023/11 Unveiling the potential protective role of quercetin against the pro-inflammatory effects of silver nanoparticles at the intestinal level Usefulness of dietary bioactive compounds and probiotics in promoting health
2023/11 Quercetin ameliorates mouse intestinal inflammation induced by silver nanoparticles XXVII Encontro Luso Galego de Química
(Portugal)
2023/11 Silver Nanoparticles Induce an Increased Production of Intestinal Inflammatory Cytokines via NF-kappaB Pathway: An In Vivo Study International Scientific Conference Applications of Chemistry in Nanosciences and Biomaterials Engineering
2022/11 Silver nanoparticles exert toxic effects in human monocytes and macrophages associated with the disruption of mitochondrial membrane potential and release of pro-inflammatory cytokines XXVI Encontro Galego-Portugués de Química
(Santiago de Compostela, Spain)
2021/06 In vitro protective role of flavonoids against the harmful effect of silver nanoparticles in cells of the gastrointestinal tract 2nd International Webinar on Chemistry and Pharmaceutical Chemistry
2021/05 Silver nanoparticles activate neutrophils’ oxidative burst via a pathway inhibitable by flavonoids 14th Young Researchers Meeting
2020/01 Chalcones modulate the production of reactive species and NETs release by human neutrophils in normal and hyperglycemic conditions 13th National Organic Chemistry Meeting (13ENQO) and the 6th National Medicinal Chemistry Meeting (6ENQT)
(Aveiro, Portugal)
2019/11 Chalcones as modulators of neutrophils' oxidative burst, in physiological and hyperglycemic conditions XXV Encontro Galego-Portugués de Química
(Santiago de Compostela, Spain)
2019/10/09 Efeito modulador das chalconas em modelos in vitro de diabetes melitus: papel da atividade antioxidante I SIMPÓSIO INTERNACIONAL DE NUTRIÇÃO
(Maceió, Brazil)
2017/10 Prediction of anti-diabetic activity of flavonoids targeting alpha-glucosidase 22nd International Congress on Prevention of Diabetes and Complications
(Londres, United Kingdom)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/07/10 - 2023/07/14 “Universidade Júnior” program of Porto University in the project: "O admirável mundo da inflamação" (2023/07/10 - 2023/07/14) Universidade do Porto, Portugal
2022/07/25 - 2022/07/29 “Universidade Júnior” program of Porto University in the project: "O admirável mundo da inflamação" (2022/07/25 - 2022/07/29) Universidade do Porto, Portugal
2019/07/08 - 2019/07/12 “Universidade Júnior” program of Porto University in the project: "O admirável mundo da inflamação" (2019/07/01 - 2019/07/31)
Other (Co-organisor)
 Universidade do Porto Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2017/09/28 - Current Ciclo de Conferências
Conference
 “Transversalidade da Química Farmacêutica Medicinal”
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/26 - Current Conference
Conference
 Inovação e Research&Development em Indústria Farmacêutica
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2022/12/13 - 2022/12/16 Advanced course (3 ECTS) “Citometria de Fluxo: dos princípios básicos às aplicações práticas”
Universidade do Porto Faculdade de Farmácia, Portugal
2021/09/06 - 2021/09/17 Advanced course Advanced Laboratory Animal Science Course: FELASA accredited Course for functions A, B and D (mouse, rat, zebrafish and fish species-specific) aligned with the European Directive 2010/63
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/06/14 - 2021/06/14 Course “Nanocytometry, cell sorting and functional assays” at the XVII Congress of the Iberian Society of Cytometry, Online, Iberian Society of Cytometry; IPO-Porto; University Hospital Centre of Porto; University Hospital Centre of Coimbra
2021/05/24 - 2021/05/28 Advanced Course “Principles of Drug Design, Synthesis and Structure-Activity Relationships in Medicinal Chemistry”
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/09/30 - 2020/12/16 Conference
Conference
 “Doenças Autoimunes” Online, 2M Pharma; OxxyO3 Natural Boost; Hawa Pharma and Prima Lab
2020/06/30 - 2020/06/30 Conference
Conference
 “Cómo indexarse en bases internacionales de citas”, Online, Enago Academy
2020/06/24 - 2020/06/24 Conference
Conference
 “A Masterclass on Research Reporting and Ethical Reproducibility in Life Sciences” , Online, Enago Academy
2020/06/23 - 2020/06/23 Course “Técnicas de pesquisa avançada em bases de dados”
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/06/15 - 2020/06/15 Course “PubMed: pesquisa por palavra e assunto, limitação de resultados, acesso ao texto integral dos artigos”
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/05/15 - 2020/05/15 Course “Fator de Impacto”
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/05/08 - 2020/05/08 Course “Web of Science e Scopus: pesquisa em bases de dados de citações”
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/05/05 - 2020/05/05 Course “Introdução ao EndNote X9: da criação de uma biblioteca à escrita de um documento”
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/06/13 - 2019/06/13 Training course Junior University: Monitor Training Program
Universidade do Porto Faculdade de Psicologia e de Ciências da Educação, Portugal
2016/12/07 - 2016/12/07 Course “Introduction to the writing of a scientific article: original article and review article” taught by Dr. Manuel Montenegro
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/06/09 - 2023/06/09 Oral presentation and practical activities conducted with children at the Ciência Viva Science Centre (Biological Park of Gaia, Porto, Portugal) under the theme: “Antioxidantes: os Guardiões do Corpo Humano”. (Menos de 4 anos de escolaridade) Ciência Viva, Portugal
2023/05/19 - 2023/05/19 Oral presentation and practical activities conducted with children at the Ciência Viva Science Centre (Biological Park of Gaia, Porto, Portugal) under the theme: “Detetive por um dia”. (Menos de 4 anos de escolaridade) Ciência Viva, Portugal
2023/04/15 - 2023/04/15 Laboratory Class on Toxicological Control from the Master's degree in Quality Control, with the theme: "Isolation and Detection of Oxidative Burst in Human Neutrophils" Controlo de Qualidade (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2022/06/20 - 2022/06/20 Instrumental Analysis Methods Applied to Pharmacology and Toxicology in the Doctoral Programme in Experimental and Clinical Pharmacology and Toxicology Farmacologia e Toxicologia Experimentais e Clínicas (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2022/05/13 - 2022/05/13 Oral presentation and practical activities conducted with children at the Ciência Viva Science Centre (Biological Park of Gaia, Porto, Portugal) under the theme: “Detetive por um dia”. (Menos de 4 anos de escolaridade) Ciência Viva, Portugal
2022/04/08 - 2022/04/08 Oral presentation and practical activities conducted with children at the Ciência Viva Science Centre (Biological Park of Gaia, Porto, Portugal) under the theme: “Química, física, ação!” (Menos de 4 anos de escolaridade) Ciência Viva, Portugal
2022/04/02 - 2022/04/02 Laboratory Class on Toxicological Control from the Master's degree in Quality Control, with the theme: "Isolation and Detection of Oxidative Burst in Human Neutrophils" Controlo de Qualidade (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2022/02/25 - 2022/02/25 Oral presentation and practical activities conducted with children at the Ciência Viva Science Centre (Biological Park of Gaia, Porto, Portugal) under the theme: “Brincar com a Química” (Menos de 4 anos de escolaridade) Ciência Viva, Portugal
2021/04/20 - 2021/04/20 Laboratory Class on Toxicological Control from the Master's degree in Quality Control, with the theme: "Isolation and Detection of Oxidative Burst in Human Neutrophils" Controlo de Qualidade (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal

Mentoring / Tutoring

Topic Student name
2023/02/01 - 2024/07/31 A student of the Bachelor’s in Biochemistry of the Faculty of Sciences of the University of Porto/Institute of Biomedical Sciences Abel Salazar, with the theme “Evaluation of the pro-inflammatory effect of silver nanoparticles on intestinal cells” Inês Alexandre Santos
2022/03/01 - 2022/07/31 A student of the Master’s in Bioengineering of the Faculty of Engineering of the University of Porto/Institute of Biomedical Sciences Abel Salazar, with the theme “Evaluation of the pro-inflammatory effect of silver nanoparticles in an animal model”. Ariana Raquel Pinto Gomes
2021/02/01 - 2021/07/31 A student of the Bachelor’s in Biochemistry of the Faculty of Sciences of the University of Porto/Institute of Biomedical Sciences Abel Salazar, with the theme “Protective effect of flavonoids on neutrophils treated with silver nanoparticles” Jorge Miguel Almeida Silva
2019/09/01 - 2020/07/31 A student of the Bachelor’s in Biochemistry of the Faculty of Sciences of the University of Porto/Institute of Biomedical Sciences Abel Salazar, with the theme “Evaluation of the effect of silver nanoparticles on the oxidative burst of human neutrophils”. Ana Patrícia Corunha Lei Barreiros Ramalho

Scientific expedition

Activity description Institution / Organization
2023/09/01 - 2023/09/30 Erasmus+ Programme at the IUF – Leibniz Research Institute for Environmental Medicine, with the traineeship title “Development and Establishment of a Healthy Intestinal Co-Culture Model for Exploring the Effects of Silver Nanoparticles and Quercetin” IUF - Leibniz-Institut für umweltmedizinische Forschung GmbH, Germany
2022/05/18 - 2022/06/07 Participation in the preparation of histological slides and their subsequent analysis as part of an in vivo study, with the theme “Use of flavonoids in the prophylaxis of intestinal pro-inflammatory effects of silver nanoparticles” Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01/24 - 2022/01/28 Participation in an in vivo study with the theme “Interdisciplinary in silico, organic synthesis, in vitro, and in vivo studies towards new antidiabetic flavonoid scaffolds” Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/12/13 - 2021/12/17 Participation in an in vivo study with the theme “Use of flavonoids in the prophylaxis of intestinal pro-inflammatory effects of silver nanoparticles” Universidade de Coimbra Faculdade de Farmácia, Portugal
Distinctions

Award

2020 4-Year Doctoral Fellowship by the FCT/SPQ within the framework of the International Year of the Periodic Table.
Fundação para a Ciência e a Tecnologia, Portugal

Sociedade Portuguesa de Química, Portugal