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Research aim: To understand how neuroinflammatory reactions are mediated in neurodegenerative diseases, especially at the level of non-coding RNAs. We use interdisciplinary approaches and novel, human based models to find novel therapeutic targets for the disease benefit. At present my research group consists of 1 senior scientists, 8 postdoctoral fellows, 9 PhD students, 3 technician and 3 undergraduate students. In addition, I am a secondary supervisor for another 9 ongoing PhD thesis. I defended my thesis on the role of glial cells in Alzheimer’s disease (AD) on 2006 (under primary supervision of Prof. Jari Koistinaho) and was the first to report the infiltration of bone-marrow derived cells into the AD brain. I carried out my postdoctoral year in Prof. Gary Landreth’s laboratory at the Case Western Researve University, Cleveland, Ohio focused on AD pathogenesis. My extremely fruitful one-year visit led to 4 publications and two other manuscripts in preparation and led to several new joint projects and grant applications. My recent research has led to a totally new research opening at the University of Eastern Finland and to a licenced patent application demonstrating the novelty and applicability of my research. I returned to the University of Eastern Finland to undertake the position of Assistant Professor in 2014 and was appointed as Associate Professor in Neuroinflammation (tenure track) in 2015. I received the Academy of Finland Research Fellow funding in May 2016, which is the most acknowledged funding in Finland for PIs at the stage of establishing their own research group. The research led by the applicant has a huge utilization potential as demonstrated by the Key project funding secured by the applicant in September 2016. I've published 80 articles in peer-reviewed scientific journals, have 2 patent(s) registered, organized 7 event(s) and received 3 awards and/or honors. Also I participate and/or participated as Principal investigator in 16 project(s).
Identification

Personal identification

Full name
Tarja Malm

Citation names

  • Malm, Tarja

Author identifiers

Ciência ID
8E11-D23F-218B
Scopus Author Id
Malm, Tarja Maarit

Email addresses

  • tarja.malm@uef.fi (Professional)

Telephones

Telephone
  • (+358) 403552209 (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
Finnish (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Swedish Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
German Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2006
Concluded
Neurobiology (Doktor (PhD))
Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
"Glial cells in Alzheimer's Disease Models" (THESIS/DISSERTATION)
PhD
2002
Concluded
Applied Biotechnology (Master)
Itä-Suomen yliopisto - Kuopion kampus, Finland
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2019/07 - Current Full Professor (University Teacher) Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
(...)

Others

Category
Host institution
Employer
2015/05/01 - 2019/07 Associate Professor in Neuroinflammation Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
2013/12/01 - 2015/04/30 Senior researcher, in research group led by Prof. Jari Koistinaho Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
2009/09/01 - 2013/12/31 Finland's Academy Postdoctoral Fellow Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
2007/01/01 - 2012/11/30 Postdoctoral researcher Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
2002/04/01 - 2006/12/09 Ph.D. student,Prof. Jari Koistinaho’s research group Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
2002/01/01 - 2006/01/01 Part-time contract researcher, Cerebricon Ltd., Kuopio, Finland Cerebricon Ltd., Finland
Projects

Grant

Designation Funders
2020 - 2022 Business Finland, “EVE” consortium
NA
Principal investigator
Ongoing
2020 - 2022 Horizon 2020 JPND-Cofund “ADAIR”
NA
Principal investigator
2020 - 2022 Horizon 2020 JPND-Cofund “ORGATHERAPY”
NA
Principal investigator
2020 - 2022 Identification and clinical validation of biomarkers for long-term outcome after cerebral ischemia (iBioStroke)
NA
Principal investigator
Ongoing
2016 - 2022 Regulation of Neuroinflammation in Alzheimer’s Disease by Non-coding RNAs
NA
Principal investigator
Ongoing
2020 - 2021 Business Finland, “R2Therapies"
NA
Principal investigator
Ongoing
2020 - 2021 Impact of early AD pathology of neuronal network functions in humans (NEUN)
NA
Principal investigator
2017 - 2021 Brain Aquaporins: Novel Therapeutic Targets for Parkinson’s Disease
NA
Principal investigator
2017/01/01 - 2019/01/01 Building an immunocompetent Alzheimer’s disease brain-on-a-chip
Principal investigator
Concluded
2015 - 2019 MiRNA based therapy in stroke
NA
Principal investigator
Emil Aaltosen Säätiö
Concluded
2016/01/01 - 2018/12/31 Advanced experimental models of neurodegenerative diseases
info:eu-repo/grantAgreement/AKA/301234/FI
Principal investigator
2016/01/01 - 2018/12/31 Neurologic and Psychiatric Disorders: from synapses to network
692340
Concluded
2016 - 2018 Generation of Improved Cellular and Animal Models for Identification of Disease Phenotype and New Therapeutic Targets of Alzheimer’s Disease (MADGIC)
JPCOFUND/003/2015
Principal investigator
Concluded
2016 - 2018 Shifting the gear: from cells to Alzheimer’s disease biomarkers
NA
Concluded
2012 - 2014 Immunomodulation based treatment for neurodegenerative diseases
NA
Principal investigator
Concluded
2010/01/01 - 2013/12/31 The Role of Bone Marrow Derived Cells in Alzheimer's disease Models
info:eu-repo/grantAgreement/AKA/133075/FI
Principal investigator
Suomen Akatemia
2009 - 2011 Modified adult stem cells for treating neurodegenerative and cardiovascular diseases
NA
Principal investigator
Concluded
2008 - 2010 Progenitor cells: promotion of mitochondrial transfer and tissue repair as novel therapeutic approaches
NA
Principal investigator
Concluded
Outputs

Publications

Journal article
  1. Heiskanen, Marja A.; Honkala, Sanna M.; Hentilä, Jaakko; Ojala, Ronja; Lautamäki, Riikka; Koskensalo, Kalle; Lietzén, Martin S.; et al. "Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight". BMC Sports Science, Medicine and Rehabilitation 13 1 (2021): http://dx.doi.org/10.1186/s13102-021-00241-z.
    10.1186/s13102-021-00241-z
  2. Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T.; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K.; et al. "An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-81741-3.
    10.1038/s41598-021-81741-3
  3. Bakreen, Abdulhameed; Juntunen, Miia; Dunlop, Yannick; Ugidos, Irene F.; Malm, Tarja; Miettinen, Susanna; Jolkkonen, Jukka. "Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats". International Journal of Molecular Sciences 22 4 (2021): 1512. http://dx.doi.org/10.3390/ijms22041512.
    10.3390/ijms22041512
  4. Pistono, Cristiana; Bister, Nea; Stanová, Iveta; Malm, Tarja. "Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease". Frontiers in Cell and Developmental Biology 8 (2021): http://dx.doi.org/10.3389/fcell.2020.623771.
    10.3389/fcell.2020.623771
  5. Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Caligola, Simone; Turunen, Tiia A.; Turunen, Mikko P.; Hernandez de Sande, Ana; et al. "Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals". Aging Cell 20 1 (2020): http://dx.doi.org/10.1111/acel.13287.
    10.1111/acel.13287
  6. White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel. "Editorial: Air pollution and brain health". Neurochemistry International 141 (2020): 104900. http://dx.doi.org/10.1016/j.neuint.2020.104900.
    10.1016/j.neuint.2020.104900
  7. Bister, Nea; Pistono, Cristiana; Huremagic, Benjamin; Jolkkonen, Jukka; Giugno, Rosalba; Malm, Tarja. "Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions". Journal of Extracellular Vesicles 10 1 (2020): http://dx.doi.org/10.1002/jev2.12002.
    10.1002/jev2.12002
  8. Nurkhametova, Dilyara; Siniavin, Andrei; Streltsova, Maria; Kudryavtsev, Denis; Kudryavtsev, Igor; Giniatullina, Raisa; Tsetlin, Victor; Malm, Tarja; Giniatullin, Rashid. "Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.548376.
    10.3389/fncel.2020.548376
  9. Irina Belaya; Mariia Ivanova; Annika Sorvari; Marina Ilicic; Sanna Loppi; Hennariikka Koivisto; Alessandra Varricchio; et al. "Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease". Journal of Neuroinflammation 17 271 (2020):
    Open access • Published • 10.1186/s12974-020-01935-w
  10. Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; et al. "Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation". Journal of Neuroinflammation 17 1 (2020): http://dx.doi.org/10.1186/s12974-020-01870-w.
    10.1186/s12974-020-01870-w
  11. Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M.; et al. "Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells". Particle and Fibre Toxicology 17 1 (2020): http://dx.doi.org/10.1186/s12989-020-00352-4.
    10.1186/s12989-020-00352-4
  12. Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi I.; Kanninen, Katja M.; Malm, Tarja. "Glial smog: Interplay between air pollution and astrocyte-microglia interactions". Neurochemistry International 136 (2020): 104715. http://dx.doi.org/10.1016/j.neuint.2020.104715.
    10.1016/j.neuint.2020.104715
  13. Chew, Sweelin; Kolosowska, Natalia; Saveleva, Liudmila; Malm, Tarja; Kanninen, Katja M.. "Impairment of mitochondrial function by particulate matter: Implications for the brain". Neurochemistry International 135 (2020): 104694. http://dx.doi.org/10.1016/j.neuint.2020.104694.
    10.1016/j.neuint.2020.104694
  14. Malmberg, Maja; Malm, Tarja; Gustafsson, Oskar; Sturchio, Andrea; Graff, Caroline; Espay, Alberto J.; Wright, Anthony P.; et al. "Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology". Frontiers in Neuroscience 14 (2020): http://dx.doi.org/10.3389/fnins.2020.00256.
    10.3389/fnins.2020.00256
  15. Konttinen, Henna; Cabral-da-Silva, Mauricio e Castro; Ohtonen, Sohvi; Wojciechowski, Sara; Shakirzyanova, Anastasia; Caligola, Simone; Giugno, Rosalba; et al. "PSEN1deltaE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia". Stem Cell Reports 13 4 (2019): 669-683. http://dx.doi.org/10.1016/j.stemcr.2019.08.004.
    10.1016/j.stemcr.2019.08.004
  16. Katisko, Kasper; Solje, Eino; Korhonen, Paula; Jääskeläinen, Olli; Loppi, Sanna; Hartikainen, Päivi; Koivisto, Anne M.; et al. "Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion". Journal of Neurology 267 1 (2019): 76-86. http://dx.doi.org/10.1007/s00415-019-09552-1.
    10.1007/s00415-019-09552-1
  17. Kolosowska, Natalia; Keuters, Meike H.; Wojciechowski, Sara; Keksa-Goldsteine, Velta; Laine, Mika; Malm, Tarja; Goldsteins, Gundars; Koistinaho, Jari; Dhungana, Hiramani. "Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke". Neurotherapeutics 16 4 (2019): 1304-1319. http://dx.doi.org/10.1007/s13311-019-00761-0.
    10.1007/s13311-019-00761-0
  18. Turunen, Tiia A.; Roberts, Thomas C.; Laitinen, Pia; Väänänen, Mari-Anna; Korhonen, Paula; Malm, Tarja; Ylä-Herttuala, Seppo; Turunen, Mikko P.. "Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-46841-1.
    10.1038/s41598-019-46841-1
  19. Singh, Yajuvinder; Leinonen, Henri; Fazaludeen, Feroze; Jaronen, Merja; Guest, Debbie; Buckley, Noel; Byts, Nadiya; et al. "Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice". Human Molecular Genetics 28 19 (2019): 3309-3322. http://dx.doi.org/10.1093/hmg/ddz165.
    10.1093/hmg/ddz165
  20. Korhonen, Paula; Pollari, Eveliina; Kanninen, Katja M.; Savchenko, Ekaterina; Lehtonen, Šárka; Wojciechowski, Sara; Pomeshchik, Yuriy; et al. "Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis". IBRO Reports 6 (2019): 74-86. http://dx.doi.org/10.1016/j.ibror.2019.01.005.
    10.1016/j.ibror.2019.01.005
  21. Ezzat, Kariem; Pernemalm, Maria; Pålsson, Sandra; Roberts, Thomas C.; Järver, Peter; Dondalska, Aleksandra; Bestas, Burcu; et al. "The viral protein corona directs viral pathogenesis and amyloid aggregation". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-10192-2.
    10.1038/s41467-019-10192-2
  22. Koroleva, Ksenia; Gafurov, Oleg; Guselnikova, Valeriia; Nurkhametova, Dilyara; Giniatullina, Raisa; Sitdikova, Guzel; Mattila, Olli S.; et al. "Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00195.
    10.3389/fncel.2019.00195
  23. Mikhailov, Nikita; Leskinen, Jarkko; Fagerlund, Ilkka; Poguzhelskaya, Ekaterina; Giniatullina, Raisa; Gafurov, Oleg; Malm, Tarja; et al. "Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?". Neuropharmacology 149 (2019): 113-123. http://dx.doi.org/10.1016/j.neuropharm.2019.02.015.
    10.1016/j.neuropharm.2019.02.015
  24. Nurkhametova, Dilyara; Kudryavtsev, Igor; Guselnikova, Valeriia; Serebryakova, Maria; Giniatullina, Raisa R.; Wojciechowski, Sara; Tore, Fatma; et al. "Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00045.
    10.3389/fncel.2019.00045
  25. Konttinen, Henna; Gureviciene, Irina; Oksanen, Minna; Grubman, Alexandra; Loppi, Sanna; Huuskonen, Mikko T.; Korhonen, Paula; et al. "PPARß/d-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes". Glia 67 1 (2018): 146-159. http://dx.doi.org/10.1002/glia.23534.
    10.1002/glia.23534
  26. Korhonen, Paula; Malm, Tarja; White, Anthony R.. "3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases". Neurochemistry International 120 (2018): 191-199. http://dx.doi.org/10.1016/j.neuint.2018.08.012.
    10.1016/j.neuint.2018.08.012
  27. Loppi, S.; Kolosowska, N.; Kärkkäinen, O.; Korhonen, P.; Huuskonen, M.; Grubman, A.; Dhungana, H.; et al. "HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage". Brain, Behavior, and Immunity 73 (2018): 670-681. http://dx.doi.org/10.1016/j.bbi.2018.07.021.
    10.1016/j.bbi.2018.07.021
  28. Nurkhametova, Dilyara; Kudryavtsev, Igor; Khayrutdinova, Olga; Serebryakova, Maria; Altunbaev, Rashid; Malm, Tarja; Giniatullin, Rashid. "Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine". Frontiers in Cellular Neuroscience 12 (2018): http://dx.doi.org/10.3389/fncel.2018.00326.
    10.3389/fncel.2018.00326
  29. Choo, Xin Yi; Liddell, Jeffrey R.; Huuskonen, Mikko T.; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; et al. "CuII(atsm) Attenuates Neuroinflammation". Frontiers in Neuroscience 12 (2018): http://dx.doi.org/10.3389/fnins.2018.00668.
    10.3389/fnins.2018.00668
  30. Nuglozeh, Edem; Fazaludeen, Mohammad Feroze; Hasona, Nabil; Malm, Tarja; Mayor, Luisito B.; Al-Hazmi, Awdah; Ashankyty, Ibraheem. "Genotyping and Frequency of PCSK9 Variations Among Hypercholesterolemic and Diabetic Subjects". Indian Journal of Clinical Biochemistry 34 4 (2018): 444-450. http://dx.doi.org/10.1007/s12291-018-0763-9.
    10.1007/s12291-018-0763-9
  31. Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M.; Malm, Tarja M.; Liddell, Jeffrey R.. "Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration". Frontiers in Neuroscience 12 (2018): http://dx.doi.org/10.3389/fnins.2018.00466.
    10.3389/fnins.2018.00466
  32. Anwer, Mehwish; Bolkvadze, Tamuna; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Rauramaa, Tuomas; Leinonen, Ville; van Vliet, Erwin A.; et al. "Sushi repeat-containing protein X-linked 2: A novel phylogenetically conserved hypothalamo-pituitary protein". Journal of Comparative Neurology 526 11 (2018): 1806-1819. http://dx.doi.org/10.1002/cne.24449.
    10.1002/cne.24449
  33. Gynther, Mikko; Proietti Silvestri, Ilaria; Hansen, Jacob C.; Hansen, Kasper B.; Malm, Tarja; Ishchenko, Yevheniia; Larsen, Younes; et al. "Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist". Journal of Medicinal Chemistry 60 23 (2017): 9885-9904. http://dx.doi.org/10.1021/acs.jmedchem.7b01624.
    10.1021/acs.jmedchem.7b01624
  34. Dhungana, Hiramani; Huuskonen, Mikko T.; Jaronen, Merja; Lemarchant, Sighild; Ali, Humair; Keksa-Goldsteine, Velta; Goldsteins, Gundars; et al. "Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation". Journal of Neuroinflammation 14 1 (2017): http://dx.doi.org/10.1186/s12974-017-1010-7.
    10.1186/s12974-017-1010-7
  35. Martiskainen, Henna; Paldanius, Kaisa M. A.; Natunen, Teemu; Takalo, Mari; Marttinen, Mikael; Leskelä, Stina; Huber, Nadine; et al. "DHCR24 exerts neuroprotection upon inflammation-induced neuronal death". Journal of Neuroinflammation 14 1 (2017): http://dx.doi.org/10.1186/s12974-017-0991-6.
    10.1186/s12974-017-0991-6
  36. Nissinen, Jari; Andrade, Pedro; Natunen, Teemu; Hiltunen, Mikko; Malm, Tarja; Kanninen, Katja; Soares, Joana I.; et al. "Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy". Epilepsy Research 136 (2017): 18-34. http://dx.doi.org/10.1016/j.eplepsyres.2017.07.005.
    10.1016/j.eplepsyres.2017.07.005
  37. Vellonen, Kati-Sisko; Ihalainen, Jouni; Boucau, Marie-Christine; Gosselet, Fabien; Picardat, Théo; Gynther, Mikko; Kanninen, Katja M.; et al. "Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer’s Disease". Pharmaceutical Research 34 12 (2017): 2652-2662. http://dx.doi.org/10.1007/s11095-017-2263-7.
    10.1007/s11095-017-2263-7
  38. Savchenko, Ekaterina; Singh, Yajuvinder; Konttinen, Henna; Lejavova, Katarina; Mediavilla Santos, Laura; Grubman, Alexandra; Kärkkäinen, Virve; et al. "Loss ofCln5causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder". Disease Models & Mechanisms 10 9 (2017): 1089-1100. http://dx.doi.org/10.1242/dmm.029165.
    10.1242/dmm.029165
  39. Piirainen, Sami; Youssef, Andrew; Song, Cai; Kalueff, Allan V.; Landreth, Gary E.; Malm, Tarja; Tian, Li. "Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?". Neuroscience & Biobehavioral Reviews 77 (2017): 148-164. http://dx.doi.org/10.1016/j.neubiorev.2017.01.046.
    10.1016/j.neubiorev.2017.01.046
  40. Leinonen, Henri; Keksa-Goldsteine, Velta; Ragauskas, Symantas; Kohlmann, Philip; Singh, Yajuvinder; Savchenko, Ekaterina; Puranen, Jooseppi; et al. "Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/s41598-017-01716-1.
    10.1038/s41598-017-01716-1
  41. Mariani, M. M.; Malm, T.; Lamb, R.; Jay, T. R.; Neilson, L.; Casali, B.; Medarametla, L.; Landreth, G. E.. "Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/srep42270.
    10.1038/srep42270
  42. Dhungana, Hiramani; Huuskonen, Mikko T; Pihlajaniemi, Taina; Heljasvaara, Ritva; Vivien, Denis; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Lemarchant, Sighild. "Lack of collagen XV is protective after ischemic stroke in mice". Cell Death & Disease 8 1 (2017): e2541-e2541. http://dx.doi.org/10.1038/cddis.2016.456.
    10.1038/cddis.2016.456
  43. Huuskonen, Mikko T.; Tuo, Qing-zhang; Loppi, Sanna; Dhungana, Hiramani; Korhonen, Paula; McInnes, Lachlan E.; Donnelly, Paul S.; et al. "The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu". Neurotherapeutics 14 2 (2017): 519-532. http://dx.doi.org/10.1007/s13311-016-0504-9.
    10.1007/s13311-016-0504-9
  44. Savchenko, Ekaterina; Malm, Tarja; Konttinen, Henna; Hämäläinen, Riikka H.; Guerrero-Toro, Cindy; Wojciechowski, Sara; Giniatullin, Rashid; Koistinaho, Jari; Magga, Johanna. "Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment". Frontiers in Cellular Neuroscience 10 (2016): http://dx.doi.org/10.3389/fncel.2016.00279.
    10.3389/fncel.2016.00279
  45. Abushik, Polina A; Bart, Geneviève; Korhonen, Paula; Leinonen, Hanna; Giniatullina, Raisa; Sibarov, Dmitry A; Levonen, Anna-Liisa; et al. "Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling". Cephalalgia 37 14 (2016): 1373-1383. http://dx.doi.org/10.1177/0333102416681588.
    10.1177/0333102416681588
  46. Grubman, Alexandra; Kanninen, Katja M; Malm, Tarja. "Multitasking Microglia and Alzheimer’s Disease: Diversity, Tools and Therapeutic Targets". Journal of Molecular Neuroscience 60 3 (2016): 390-404. http://dx.doi.org/10.1007/s12031-016-0825-5.
    10.1007/s12031-016-0825-5
  47. Huuskonen, Mikko T.; Loppi, Sanna; Dhungana, Hiramani; Keksa-Goldsteine, Velta; Lemarchant, Sighild; Korhonen, Paula; Wojciechowski, Sara; et al. "Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep33176.
    10.1038/srep33176
  48. Malm, Tarja; Loppi, Sanna; Kanninen, Katja M.. "Exosomes in Alzheimer's disease". Neurochemistry International 97 (2016): 193-199. http://dx.doi.org/10.1016/j.neuint.2016.04.011.
    10.1016/j.neuint.2016.04.011
  49. Lemarchant, Sighild; Dunghana, Hiramani; Pomeshchik, Yuriy; Leinonen, Henri; Kolosowska, Natalia; Korhonen, Paula; Kanninen, Katja M.; et al. "Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke". Glia 64 9 (2016): 1492-1507. http://dx.doi.org/10.1002/glia.23017.
    10.1002/glia.23017
  50. Kanninen, Katja M.; Bister, Nea; Koistinaho, Jari; Malm, Tarja. "Exosomes as new diagnostic tools in CNS diseases". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1862 3 (2016): 403-410. http://dx.doi.org/10.1016/j.bbadis.2015.09.020.
    10.1016/j.bbadis.2015.09.020
  51. Liddell, Jeffrey R.; Lehtonen, Sarka; Duncan, Clare; Keksa-Goldsteine, Velta; Levonen, Anna-Liisa; Goldsteins, Gundars; Malm, Tarja; et al. "Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes". Journal of Neuroinflammation 13 1 (2016): http://dx.doi.org/10.1186/s12974-016-0515-9.
    10.1186/s12974-016-0515-9
  52. Lemarchant, Sighild; Pomeshchik, Yuriy; Kidin, Iurii; Kärkkäinen, Virve; Valonen, Piia; Lehtonen, Sarka; Goldsteins, Gundars; et al. "Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis". Molecular Neurodegeneration 11 1 (2016): http://dx.doi.org/10.1186/s13024-016-0080-9.
    10.1186/s13024-016-0080-9
  53. Lemarchant, Sighild; Pomeshchik, Yuriy; Kidin, Iurii; Kärkkäinen, Virve; Valonen, Piia; Lehtonen, Sarka; Goldsteins, Gundars; et al. "ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis". Molecular Neurodegeneration 11 1 (2016): http://dx.doi.org/10.1186/s13024-016-0078-3.
    10.1186/s13024-016-0078-3
  54. Rolova, Taisia; Dhungana, Hiramani; Korhonen, Paula; Valonen, Piia; Kolosowska, Natalia; Konttinen, Henna; Kanninen, Katja; et al. "Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage". Aging and Disease 7 4 (2016): 450. http://dx.doi.org/10.14336/ad.2015.1123.
    10.14336/ad.2015.1123
  55. Kanninen, Katja M.; Pomeshchik, Yuriy; Leinonen, Hanna; Malm, Tarja; Koistinaho, Jari; Levonen, Anna-Liisa. "Applications of the Keap1–Nrf2 system for gene and cell therapy". Free Radical Biology and Medicine 88 (2015): 350-361. http://dx.doi.org/10.1016/j.freeradbiomed.2015.06.037.
    10.1016/j.freeradbiomed.2015.06.037
  56. Korhonen, Paula; Kanninen, Katja M.; Lehtonen, Šárka; Lemarchant, Sighild; Puttonen, Katja A.; Oksanen, Minna; Dhungana, Hiramani; et al. "Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation". Brain, Behavior, and Immunity 49 (2015): 322-336. http://dx.doi.org/10.1016/j.bbi.2015.06.013.
    10.1016/j.bbi.2015.06.013
  57. Maysami, Samaneh; Wong, Raymond; Pradillo, Jesus M; Denes, Adam; Dhungana, Hiramani; Malm, Tarja; Koistinaho, Jari; et al. "A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke". Journal of Cerebral Blood Flow & Metabolism 36 3 (2015): 596-605. http://dx.doi.org/10.1177/0271678x15606714.
    10.1177/0271678x15606714
  58. Pomeshchik, Yuriy; Puttonen, Katja A.; Kidin, Iurii; Ruponen, Marika; Lehtonen, Sarka; Malm, Tarja; Åkesson, Elisabet; Hovatta, Outi; Koistinaho, Jari. "Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice with Contusion Spinal Cord Injury". Cell Transplantation 24 9 (2015): 1799-1812. http://dx.doi.org/10.3727/096368914x684079.
    10.3727/096368914x684079
  59. Savage, J. C.; Jay, T.; Goduni, E.; Quigley, C.; Mariani, M. M.; Malm, T.; Ransohoff, R. M.; Lamb, B. T.; Landreth, G. E.. "Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease". Journal of Neuroscience 35 16 (2015): 6532-6543. http://dx.doi.org/10.1523/jneurosci.4586-14.2015.
    10.1523/jneurosci.4586-14.2015
  60. Pomeshchik, Yuriy; Kidin, Iurii; Korhonen, Paula; Savchenko, Ekaterina; Jaronen, Merja; Lehtonen, Sarka; Wojciechowski, Sara; et al. "Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury". Brain, Behavior, and Immunity 44 (2015): 68-81. http://dx.doi.org/10.1016/j.bbi.2014.08.002.
    10.1016/j.bbi.2014.08.002
  61. Malm, Tarja; Mariani, Monica; Donovan, Lauren J; Neilson, Lee; Landreth, Gary E. "Activation of the nuclear receptor PPARd is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation". Journal of Neuroinflammation 12 1 (2015): 7. http://dx.doi.org/10.1186/s12974-014-0229-9.
    10.1186/s12974-014-0229-9
  62. Skerrett, Rebecca; Malm, Tarja; Landreth, Gary. "Nuclear receptors in neurodegenerative diseases". Neurobiology of Disease 72 (2014): 104-116. http://dx.doi.org/10.1016/j.nbd.2014.05.019.
    10.1016/j.nbd.2014.05.019
  63. Malm, Tarja M.; Jay, Taylor R.; Landreth, Gary E.. "The Evolving Biology of Microglia in Alzheimer’s Disease". Neurotherapeutics 12 1 (2014): 81-93. http://dx.doi.org/10.1007/s13311-014-0316-8.
    10.1007/s13311-014-0316-8
  64. Kärkkäinen, Virve; Pomeshchik, Yuriy; Savchenko, Ekaterina; Dhungana, Hiramani; Kurronen, Antti; Lehtonen, Sarka; Naumenko, Nikolay; et al. "Nrf2 Regulates Neurogenesis and Protects Neural Progenitor Cells Against Aß Toxicity". STEM CELLS 32 7 (2014): 1904-1916. http://dx.doi.org/10.1002/stem.1666.
    10.1002/stem.1666
  65. Malm, Tarja. "Susceptibility to Focal and Global Brain Ischemia of Alzheimer Mice Displaying Aß Deposits: Effect of Immunoglobulin". Aging and Disease 5 2 (2014): http://dx.doi.org/10.14336/ad.2014.050076.
    10.14336/ad.2014.050076
  66. Rolova, Taisia; Puli, Lakshman; Magga, Johanna; Dhungana, Hiramani; Kanninen, Katja; Wojciehowski, Sara; Salminen, Antero; et al. "Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit". Neurobiology of Disease 64 (2014): 16-29. http://dx.doi.org/10.1016/j.nbd.2013.12.003.
    10.1016/j.nbd.2013.12.003
  67. Pomeshchik, Yuriy; Kidin, Iurii; Savchenko, Ekaterina; Rolova, Taisia; Yamamoto, Masayuki; Levonen, Anna-Liisa; Ylä-Herttuala, Seppo; et al. "Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?". Antioxidants & Redox Signaling 20 8 (2014): 1313-1323. http://dx.doi.org/10.1089/ars.2013.5453.
    10.1089/ars.2013.5453
  68. Dhungana, Hiramani; Rolova, Taisia; Savchenko, Ekaterina; Wojciechowski, Sara; Savolainen, Kaisa; Ruotsalainen, Anna-Kaisa; Sullivan, Patrick M; Koistinaho, Jari; Malm, Tarja. "Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele". Journal of Neuroinflammation 10 1 (2013): http://dx.doi.org/10.1186/1742-2094-10-102.
    10.1186/1742-2094-10-102
  69. Dhungana, Hiramani; Malm, Tarja; Denes, Adam; Valonen, Piia; Wojciechowski, Sara; Magga, Johanna; Savchenko, Ekaterina; et al. "Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection". Aging Cell 12 5 (2013): 842-850. http://dx.doi.org/10.1111/acel.12106.
    10.1111/acel.12106
  70. Jaronen, M.; Vehvilainen, P.; Malm, T.; Keksa-Goldsteine, V.; Pollari, E.; Valonen, P.; Koistinaho, J.; Goldsteins, G.. "Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production". Human Molecular Genetics 22 4 (2012): 646-655. http://dx.doi.org/10.1093/hmg/dds472.
    10.1093/hmg/dds472
  71. Karkkainen, Virve; Magga, Johanna; Koistinaho, Jari; Malm, Tarja. "Brain Environment and Alzheimer’s Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells". Current Alzheimer Research 9 9 (2012): 1030-1042. http://dx.doi.org/10.2174/156720512803569028.
    10.2174/156720512803569028
  72. Puli, Lakshman; Pomeshchik, Yuriy; Olas, Katja; Malm, Tarja; Koistinaho, Jari; Tanila, Heikki. "Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer’s disease". Journal of Neuroinflammation 9 1 (2012): http://dx.doi.org/10.1186/1742-2094-9-105.
    10.1186/1742-2094-9-105
  73. Magga, Johanna; Savchenko, Ekaterina; Malm, Tarja; Rolova, Taisia; Pollari, Eveliina; Valonen, Piia; Lehtonen, Šárka; et al. "Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer’s disease". Journal of Cellular and Molecular Medicine 16 5 (2012): 1060-1073. http://dx.doi.org/10.1111/j.1582-4934.2011.01390.x.
    10.1111/j.1582-4934.2011.01390.x
  74. Malm, Tarja; Magga, Johanna; Koistinaho, Jari. "Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance". Current Translational Geriatrics and Experimental Gerontology Reports 1 1 (2012): 11-20. http://dx.doi.org/10.1007/s13670-011-0004-z.
    10.1007/s13670-011-0004-z
  75. Kanninen, Katja; White, Anthony R.; Koistinaho, Jari; Malm, Tarja. "Targeting Glycogen Synthase Kinase-3ßfor Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway". International Journal of Alzheimer's Disease 2011 (2011): 1-9. http://dx.doi.org/10.4061/2011/985085.
    10.4061/2011/985085
  76. Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars. "Glycogen Synthase Kinase-3ß: A Mediator of Inflammation in Alzheimer's Disease?". International Journal of Alzheimer's Disease 2011 (2011): 1-9. http://dx.doi.org/10.4061/2011/129753.
    10.4061/2011/129753
  77. Pollari, Eveliina; Savchenko, Ekaterina; Jaronen, Merja; Kanninen, Katja; Malm, Tarja; Wojciechowski, Sara; Ahtoniemi, Toni; et al. "Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis". Journal of Neuroinflammation 8 1 (2011): 74. http://dx.doi.org/10.1186/1742-2094-8-74.
    10.1186/1742-2094-8-74
  78. Malm, Tarja; Koistinaho, Jari; Kanninen, Katja. "Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications". International Journal of Alzheimer's Disease 2011 (2011): 1-8. http://dx.doi.org/10.4061/2011/517160.
    10.4061/2011/517160
  79. Malm, Tarja; Koistinaho, Milla; Muona, Anu; Magga, Johanna; Koistinaho, Jari. "The role and therapeutic potential of monocytic cells in Alzheimer's disease". Glia (2010): NA-NA. http://dx.doi.org/10.1002/glia.20973.
    10.1002/glia.20973
  80. Magga, Johanna; Puli, Lakshman; Pihlaja, Rea; Kanninen, Katja; Neulamaa, Suvi; Malm, Tarja; Härtig, Wolfgang; et al. "Human intravenous immunoglobulin provides protection against Aß toxicity by multiple mechanisms in a mouse model of Alzheimer's disease". Journal of Neuroinflammation 7 1 (2010): 90. http://dx.doi.org/10.1186/1742-2094-7-90.
    10.1186/1742-2094-7-90
  81. Kanninen, K.; Heikkinen, R.; Malm, T.; Rolova, T.; Kuhmonen, S.; Leinonen, H.; Yla-Herttuala, S.; et al. "Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease". Proceedings of the National Academy of Sciences 106 38 (2009): 16505-16510. http://dx.doi.org/10.1073/pnas.0908397106.
    10.1073/pnas.0908397106
  82. Malm, Tarja M.; Magga, Johanna; Kuh, Georges Ful; Vatanen, Tero; Koistinaho, Milla; Koistinaho, Jari. "Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease". Glia 56 16 (2008): 1767-1779. http://dx.doi.org/10.1002/glia.20726.
    10.1002/glia.20726
  83. Kanninen, Katja; Malm, Tarja M.; Jyrkkänen, Henna-Kaisa; Goldsteins, Gundars; Keksa-Goldsteine, Velta; Tanila, Heikki; Yamamoto, Masayuki; et al. "Nuclear factor erythroid 2-related factor 2 protects against beta amyloid". Molecular and Cellular Neuroscience 39 3 (2008): 302-313. http://dx.doi.org/10.1016/j.mcn.2008.07.010.
    10.1016/j.mcn.2008.07.010
  84. Pulkkinen, Kati; Malm, Tarja; Turunen, Mikko; Koistinaho, Jari; Ylä-Herttuala, Seppo. "Hypoxia induces microRNA miR-210 in vitro and in vivo". FEBS Letters 582 16 (2008): 2397-2401. http://dx.doi.org/10.1016/j.febslet.2008.05.048.
    10.1016/j.febslet.2008.05.048
  85. Minkeviciene, R.; Ihalainen, J.; Malm, T.; Matilainen, O.; Keksa-Goldsteine, V.; Goldsteins, G.; Iivonen, H.; et al. "Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice". Journal of Neurochemistry 105 3 (2008): 584-594. http://dx.doi.org/10.1111/j.1471-4159.2007.05147.x.
    10.1111/j.1471-4159.2007.05147.x
  86. Malm, T. M.; Iivonen, H.; Goldsteins, G.; Keksa-Goldsteine, V.; Ahtoniemi, T.; Kanninen, K.; Salminen, A.; et al. "Pyrrolidine Dithiocarbamate Activates Akt and Improves Spatial Learning in APP/PS1 Mice without Affecting  -Amyloid Burden". Journal of Neuroscience 27 14 (2007): 3712-3721. http://dx.doi.org/10.1523/jneurosci.0059-07.2007.
    10.1523/jneurosci.0059-07.2007
  87. Pihlaja, Rea; Koistinaho, Jari; Malm, Tarja; Sikkilä, Herkko; Vainio, Seppo; Koistinaho, Milla. "Transplanted astrocytes internalize deposited ß-amyloid peptides in a transgenic mouse model of Alzheimer's disease". Glia 56 2 (2007): 154-163. http://dx.doi.org/10.1002/glia.20599.
    10.1002/glia.20599
  88. Ahtoniemi, Toni; Goldsteins, Gundars; Keksa-Goldsteine, Velta; Malm, Tarja; Kanninen, Katja; Salminen, Antero; Koistinaho, Jari. "Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis". Molecular Pharmacology 71 1 (2006): 30-37. http://dx.doi.org/10.1124/mol.106.028415.
    10.1124/mol.106.028415
  89. Malm, T.; Ort, M.; Tahtivaara, L.; Jukarainen, N.; Goldsteins, G.; Puolivali, J.; Nurmi, A.; et al. "beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits". Proceedings of the National Academy of Sciences 103 23 (2006): 8852-8857. http://dx.doi.org/10.1073/pnas.0602896103.
    10.1073/pnas.0602896103
  90. Mäkinen, Petri I.; Koponen, Jonna K.; Kärkkäinen, Anna-Mari; Malm, Tarja M.; Pulkkinen, Kati H.; Koistinaho, Jari; Turunen, Mikko P.; Ylä-Herttuala, Seppo. "Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain". The Journal of Gene Medicine 8 4 (2006): 433-441. http://dx.doi.org/10.1002/jgm.860.
    10.1002/jgm.860
  91. Malm, Tarja M.; Koistinaho, Milla; Pärepalo, Maria; Vatanen, Tero; Ooka, Andreas; Karlsson, Stefan; Koistinaho, Jari. "Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to ß-amyloid deposition in APP/PS1 double transgenic Alzheimer mice". Neurobiology of Disease 18 1 (2005): 134-142. http://dx.doi.org/10.1016/j.nbd.2004.09.009.
    10.1016/j.nbd.2004.09.009
  92. Koistinaho, Milla; Malm, Tarja M; Kettunen, Mikko I; Goldsteins, Gundars; Starckx, Sofie; Kauppinen, Risto A; Opdenakker, Ghislain; Koistinaho, Jari. "Minocycline Protects against Permanent Cerebral Ischemia in Wild Type but Not in Matrix Metalloprotease-9-Deficient Mice". Journal of Cerebral Blood Flow & Metabolism 25 4 (2005): 460-467. http://dx.doi.org/10.1038/sj.jcbfm.9600040.
    10.1038/sj.jcbfm.9600040

Intellectual property

Patent
  1. Malm, Tarja. 2016. "United States Patent - IL-33 and treatment of Neurodegenerative Diseases". United States.
  2. Malm, Tarja. 2016. "European Patent - IL-33 and Treatment of Neurodegenerative Diseases".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019 Studying microglial heterogeneity and its implication in brain disorders using complementary cutting-edge technologies European Meeting on Glial Cells in Health and Disease
Porto (Porto, Portugal)
2019 Modeling microglial dysfunctions in AD European Meeting on Glial Cells in Health and Disease
Porto (Porto, Portugal)
2019 Many faces of microglia in Neurodegeneration Nordic Neuroscience meeting
(Helsinky, Finland)
2019 Non-coding RNAs in regulation of neuronal survival in co-morbid models of ischemic stroke Kazan University
(Kazan, Russia)
2018 Modeling neuroinflammation in mice Mouse as a model neuroscience research
University of Oulu (Oulu, Finland)
2018 Modeling microglia using iPSCs Lithuanian National Stem cell meeting
(Lithuania)
2018 The role of meningeal lymphatics in Alzheimer -related amyloid pathology AAIC meeting
(Chicago, United States)
2018 Modeling human microglia in neurodegeneration NeuroscienceFinland Meeting
(Helsinky, Finland)
2018 Targeting glial energy metabolism for therapeutic benefit in Alzheimer’s disease SynaNet Satellite Symposium
(Lisboa, Portugal)
2018 Alzheimerin taudin immunoterapiat Training for Neurologists
(Helsinky, Finland)
2017 iPSC-derived microglia 2nd Synanet Workshop
(Rome, Italy)
2016 Seminar Series Seminar Series
University of Helsinki (Helsinky, Finland)
2016 Cellular Immunology in the Central Nervous system and its role in Diseases
Helsinky (Helsinky, Finland)
2014 Invited lecturer in BCO/BCK symposium BCO/BCK symposium
(Oulu, Finland)
2009 Fundamentals of preclinical stroke research Translational Basic Science Stroke Research–teaching course organized during European Stroke Conference
2005 Invited lecturer in BCO/BCK symposium BCO/BCK symposium
(Oulu, Finland)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2017 - Current Secondary supervisor for 11 PhD students: Meike Keuters; Nikita Mikhailov; Antti-Ville Korhonen; Riikka Lampinen; Irina Belaya; Goncalo Garcia (enrolled in University of Lisbon); Marta Isabel de Silva Rodrigues Barbosa (enrolled in University of Lisbon); Pia Laitinen; Mari-Anna Väänänen
Co-supervisor
2017 - Current Supervised 22 MSc thesis to completion
Supervisor
2016 - Current Primary supervisor for 8 Postdocs: Paula Korhonen, Tiia Turunen, Antonios Dougalis, Anastasia Shakirzyanova, Irene Fernandex Ugidos, Anssi Pelkonen, Cristiana Pistono, Mikko Turunen
Supervisor
Itä-Suomen yliopisto A I Virtanen -instituutti, Finland
2015 - Current Primary supervisor for 7 PhD students: Feroze Fazaludeen; Ilkka Fagerlund; Flavia Scoyni; Nea Bister; Henna Konttinen; Sohvi Ohtonen; Pamela Klecki
Supervisor
2014 - Current Supervised 10 PhD thesis to completion: Dilyara Nurkhametova (April 2020) Sanna Loppi, PhD on October 2019 Natalia Kolosowska, PhD on October 2019 Yajuvinder Singh, PhD on March 2018 Mikko Huuskonen, PhD on February 2017 Taisia Rolova, PhD on December 2015 (primary supervisor) Paula Korhonen, PhD on December 2015 (primary supervisor) Ekaterina Savchenko, PhD on December 2015 Yuriy Pomeshchik, PhD on December 2014 Hiramani Dhungana, PhD on December 2014
Supervisor

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019 - 2019 Air Pollution and the Brain (2019)
2018 - 2018 Mitochondria and ROS signaling (2018)
2018 - 2018 Extracellular Vesicles (2018)
2017 - 2017 Common and Specific Mechanisms of stroke and Migraine (2017)
2017 - 2017 Glial cells (2017)
2017 - 2017 Principles of Flow Cytometry (2017)
2016 - 2016 Neuroinflammation workshop (2016)

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2016 - 2016 A reviewer for Horizon2020 Marie Curie ITN applications
2014 - 2014 A reviewer for Wetenschappeljik Fonds Willy Gepts (WFWG) foundation

Journal scientific committee

Journal title (ISSN) Publisher
2013 - Current Scientific Pages of Alzheimer’s Disease and Dementia
2013 - Current Frontiers in Neurology / stroke
2012 - Current Glia Research
2007 - Current The Journal of Neuroscience (1529-2401)
2007 - Current Virus Research (0168-1702) Elsevier
2007 - Current European Journal of Pharmacology (0014-2999) Elsevier
2007 - Current Journal of Neuroimmune Pharmacology
2007 - Current Neural Regeneration Research (1673-5374) Medknow Publications
2007 - Current Neurochemistry International (0197-0186) Elsevier
2007 - Current Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2007 - Current BioMed Research International (2314-6141) Hindawi Limited
Distinctions

Title

2006 The best thesis of the University of Kuopio
Itä-Suomen yliopisto - Kuopion kampus, Finland
2006 The best thesis of the Graduate School of Molecular Medicine
Itä-Suomen yliopisto - Kuopion kampus, Finland
2006 The best publication in the field of neuroscience
Itä-Suomen yliopisto A I Virtanen -instituutti, Finland