???global.info.a_carregar???
Identification

Personal identification

Full name
Ana Filipa Sobral

Citation names

  • Sobral, AF
  • Sobral, A.F.

Author identifiers

Ciência ID
8D11-2E0D-4537
ORCID iD
0000-0003-3674-3116
Scopus Author Id
57209069887

Email addresses

  • ana.sobral@iucs.cespu.pt (Professional)
  • filipasobral.phd@outlook.com (Personal)
  • filipasobral.phd@outlook.com (Personal)

Addresses

  • Instituto Universitário de Ciências da Saúde (IUCS), Rua Central da Gandra 1317, 4585-116, Gandra, Paredes, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2017/01/01 - 2022/06/01
Concluded
 Biomedical Sciences (Doutoramento)
Major in Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Functionalities and interplay of actin-filament crosslinkers in vivo." (THESIS/DISSERTATION)
2013/09/01 - 2015/09
Concluded
 Cell and Molecular Biology (Mestrado)
Major in Área de especialização: Biologia Molecular e Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"New steroidal aromatase inhibitors: biological effects in hormone- dependent breast cancer cell models" (THESIS/DISSERTATION)
 18 valores
2010/09 - 2013/07
Concluded
 Bioanalytical Sciences (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2024/01 - Current Researcher (Research) Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2022/01/17 - 2022/09/29 Research Assistant (Research) FairJourney Biologics SA, Portugal
2017/04/01 - 2022/01/15 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/02/15 - 2017/03/31 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/09/01 - 2015/09/22 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal
2014/03/10 - 2014/04/04 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/10/14 - 2013/11/11 Research Trainee (Research) Centro de Sangue e da Transplantação de Coimbra, Portugal
2013/07/01 - 2013/07/31 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/01/10 - Current Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2025/09/01 - Current Decoding the toxicity and transgenerational effects of synthetic cathinones and ketamine enantiomers using C. elegans as a translational model.
DeTTeCaK-GI2-CESPU-2025
Co-Principal Investigator (Co-PI)
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia & Uma Só Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário CRL
Ongoing
2021/06/01 - 2021/07/31 Functionalities and interplays of Actin-Filament Crosslinkers in vivo
COVID/BD/151810/2021
10.54499/COVID/BD/151810/2021
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/04/01 - 2021/05/31 Functionalities and interplays of Actin-Filament Crosslinkers in vivo
SFRH/BD/121874/2016
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
PhD Student Fellow
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Lemos, C.; Sobral, AF. "Exploração do modelo C. elegans na avaliação dos efeitos da catinona sintética 3-MMC". Paper presented in VII Congresso da Associação Portuguesa de Ciências Forenses, 2025.
  2. Sobral, AF; Chan, Fung-Yi; Ana Xavier Carvalho; Carvalho, Ana; Carvalho, AX. "Unravelling Actin-Filament Crosslinkers diversity in vivo". Paper presented in GENiE Workshop “The ins and outs of cytoskeleton in C. elegans”, 2019.
  3. Sobral, AF; Chan, Fung-Yi; Ana Xavier Carvalho; Carvalho, Ana; Carvalho, AX. "Unravelling Actin-Filament Crosslinkers diversity in vivo". Paper presented in EMBO Workshop “C. elegans development, cell biology and gene expression”,, 2018.
  4. Sobral, AF; Correia-da-Silva, G.; Teixeira, N.. "Biological effects of new steroidal aromatase inhibitors in hormonesensitive and resistant breast cancer cells". Paper presented in XXIII Porto Cancer Meeting, 2015.
Journal article
  1. Daniel José Barbosa; Inês C. Santos; Tatiana Moyisyeyenko; Cristina Mendes; Ana Filipa Sobral. "C. elegans as a powerful model for neurotoxicity assessment". NeuroToxicology (2025): https://doi.org/10.1016/j.neuro.2025.07.009.
    10.1016/j.neuro.2025.07.009
  2. Ana Filipa Sobral; Andrea Cunha; Inês Costa; Mariana Silva-Carvalho; Renata Silva; Daniel José Barbosa. "Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease". Journal of Xenobiotics (2025): https://doi.org/10.3390/jox15040118.
    10.3390/jox15040118
  3. Ana Filipa Sobral; Inês Costa; Vanessa Teixeira; Renata Silva; Daniel José Barbosa. "Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes". Brain Sciences (2025): https://doi.org/10.3390/brainsci15030279.
    10.3390/brainsci15030279
  4. Ana Filipa Sobral; Ricardo Jorge Dinis-Oliveira; Daniel José Barbosa. "CRISPR-Cas technology in forensic investigations: Principles, applications, and ethical considerations". Forensic Science International: Genetics (2025): http://dx.doi.org/10.1016/j.fsigen.2024.103163.
    10.1016/j.fsigen.2024.103163
  5. Renata Silva; Ana Filipa Sobral; Ricardo Jorge Dinis-Oliveira; Daniel José Barbosa. "The Link Between Paraquat and Demyelination: A Review of Current Evidence". Antioxidants (2024): https://doi.org/10.3390/antiox13111354.
    10.3390/antiox13111354
  6. Ana Filipa Sobral; Andrea da Cunha; Vera Silva; Eva Gil Martins; Renata Silva; Daniel José Barbosa. "Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration". International Journal of Molecular Sciences (2024): https://www.mdpi.com/1422-0067/25/17/9339.
    10.3390/ijms25179339
  7. AM Silva; Fung-Yi, Chan; Michael Norman; Esther Zanin; Ana Filipa Sobral; Reto Gassmann; JM Belmonte; Ana Xavier de Carvalho. "ß-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis.". The Journal of cell biology (2022): https://doi.org/10.1083/jcb.202202024.
    10.1083/jcb.202202024
  8. Ana Filipa Sobral. "Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis". Current Biology 31 24 (2021): 5415-5428.e10. http://dx.doi.org/10.1016/j.cub.2021.09.055.
    10.1016/j.cub.2021.09.055
  9. Leite, J.; Chan, F.-Y.; Osório, D.S.; Saramago, J.; Sobral, A.F.; Silva, A.M.; Gassmann, R.; Carvalho, A.X.. "Equatorial Non-muscle Myosin II and Plastin Cooperate to Align and Compact F-actin Bundles in the Cytokinetic Ring". Frontiers in Cell and Developmental Biology 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092498962&partnerID=MN8TOARS.
    10.3389/fcell.2020.573393
  10. Osório, D.S.; Chan, F.-Y.; Saramago, J.; Leite, J.; Silva, A.M.; Sobral, A.F.; Gassmann, R.; Carvalho, A.X.. "Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans". Development (Cambridge, England) 146 21 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074964249&partnerID=MN8TOARS.
    10.1242/dev.179150
  11. Leite, J.; Osorio, D.S.; Sobral, A.F.; Silva, A.M.; Carvalho, A.X.. "Network contractility during cytokinesis—from molecular to global views". Biomolecules 9 5 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066454203&partnerID=MN8TOARS.
    10.3390/biom9050194
  12. Amaral, C.; Varela, C.L.; Maurício, J.; Sobral, A.F.; Costa, S.C.; Roleira, F.M.F.; Tavares-da-Silva, E.J.; Correia-da-Silva, G.; Teixeira, N.. "Anti-tumor efficacy of new 7a-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells". Journal of Steroid Biochemistry and Molecular Biology 171 (2017): 218-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017457908&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2017.04.002
  13. Sobral, A.F.; Amaral, C.; Correia-da-Silva, G.; Teixeira, N.. "Unravelling exemestane: From biology to clinical prospects". Journal of Steroid Biochemistry and Molecular Biology 163 (2016): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962441168&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2016.03.019
Journal issue
  1. Barbosa, Daniel José; Sobral, AF; Silva, Renata; Dinis-Oliveira, Ricardo Jorge. "New Psychoactive Substances and Emerging Trends: Pharmacology, Neurotoxicity, and Public Health Implications". Psychoactives (2026): https://www.mdpi.com/journal/psychoactives/special_issues/11HH2V9D70.
  2. Barbosa, Daniel José; Sobral, AF. "Cellular and Molecular Mechanisms Regulating Neuronal Function, Homeostasis, and Disease (2nd Edition)". Brain Sciences (2026): https://www.mdpi.com/journal/brainsci/special_issues/9UV2V7V1UM.
  3. Sobral, Ana Filipa; Barbosa, DJ. "Molecular motors in neuronal homeostasis and neurodegeneration". Brain Sciences (2025): https://www.mdpi.com/journal/brainsci/special_issues/M6L3X70WW5.
    In press
Preprint
  1. Osorio, DS; Chan, FY; Saramago, J; Leite, J; Silva, AM; Sobral, AF; Gassmann, R; Carvalho, AX. "Flow-independent accumulation of motor-competent non-muscle myosin II in the contractile ring is essential for cytokinesis". 2018. https://doi.org/10.1101/333286.
    10.1101/333286
Thesis / Dissertation
  1. "Functionalities and interplay of actin-filament crosslinkers in vivo". PhD, 2022. https://hdl.handle.net/10216/141519.
  2. Sobral, Ana Filipa Fernandes Ferreira. "New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models". Master, 2015. http://hdl.handle.net/10316/32980.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/05 Cooperation between crosslinkers during cytokinesis Online Developmental Mechanics Seminar Series
2018/11 Fimbrin cooperates with myosin II during cytokinesis 7th I3S annual meeting
(Portugal)
2017 Functionalities and interplays of Actin-Filament Crosslinkers in vivo 6th I3S annual meeting
2015/09 Cell cycle arrest and apoptosis activation in breast cancer MCF7aro cells induced by new aromatase inhibitors 10th Young European Scientist Meeting
2015/05 Potential of new steroidal aromatase inhibitors in breast cancer: antiproliferative effects and cell death mechanisms JUP’15 – 8º Encontro de Investigação Jovem da Universidade do Porto
2015/04 New steroidal aromatase inhibitors: biological effects in hormone dependente breast cancer cell models V Post-Graduate National Meeting in Biological Sciences

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025/11 - Current Decoding the structure-toxicity relationship and germline toxicity of synthetic cathinones using C. elegans as a translational model
Co-supervisor
 Doutoramento em Toxicologia (PhD)
Instituto Universitário de Ciências da Saúde, Portugal
2025/09 - Current Ketamine and neuroplasticity: potential in neurodegenerative diseases.
Co-supervisor
 Integrated Master in Pharmaceutical Sciences (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2025/09 - Current Effects of exposure to the synthetic cathinone 3-MMC on the survival and development of the animal model C. elegans
Supervisor
 Bachelor Degree in Forensic Sciences (Other)
Instituto Universitário de Ciências da Saúde, Portugal
2024/10/01 - Current Impact of synthetic cathinones on C. elegans development, locomotion and reproductive behaviours, and lifespan
Supervisor
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2024/09/01 - Current Toxicology of ketamine in the C. elegans animal model
Co-supervisor
 Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2024/09/01 - 2025/09/10 Combined consumption of ethanol and imipramine: toxic effects in the C. elegans animal model
Supervisor
 Ciências Forenses (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2025/09 - 2026/04 V 1H-TOXRUN International Congress 2026 (2026/04/23 - 2026/04/24)
Congress (Member of the Organising Committee)
 Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia & Uma Só Saúde, Portugal
2024/09 - 2025/05 IV 1H-TOXRUN International Congress 2025 (2025/05/05 - 2025/05/06)
Congress (Member of the Organising Committee)
 Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia & Uma Só Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/12 - 2025/12 Talent-CGT - Teach-The-Teacher Workshop (Cell and Gene Therapies) 2025
Workshop
Avans Hogeschool Breda, Netherlands

Leids Universitair Medisch Centrum, Netherlands

Universiteit Utrecht, Netherlands
2025/10 - 2025/10 VII PhD Day IUCS 2025
Meeting
Instituto Universitário de Ciências da Saúde, Portugal
2025/10 - 2025/10 Epigenetic CRISPR-dCas9 editing course 2025
Workshop
Avans Hogeschool Breda, Netherlands
2025/05 - 2025/05 IV 1H-TOXRUN International Congress 2025
Congress
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia & Uma Só Saúde, Portugal
2024/10/20 - 2024/10/26 ERASMUS + Programme
Workshop
Erasmushogeschool Brussel, Belgium
2024/10 - 2024/10 VI PhD Day IUCS 2024
Meeting
Instituto Universitário de Ciências da Saúde, Portugal
2024/05 - 2024/05 III 1H-ToxRun International Congress 2024
Congress
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia & Uma Só Saúde, Portugal
2024/04 - 2024/04 Jornadas Científicas AEIUCS
Conference
Instituto Universitário de Ciências da Saúde, Portugal
2021 - 2021 Career Development Workshop “I have a PhD! What’s next?”
Symposium
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/11 - 2019/11 8th i3S annual meeting
Conference
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/02 - 2019/02 GENiE Workshop “The ins and outs of cytoskeleton in C. elegans”
Workshop
Tel Aviv University, Israel
2018/11 - 2018/11 7th I3S annual meeting
Conference
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/06 - 2018/06 EMBO workshop “C. elegans development, cell biology and gene expression"
Workshop
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
2018/05 - 2018/05 1º Encontro de Doutoramento em Ciências Biomédicas do ICBAS
Meeting
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/05 - 2018/05 1st PhDay at i3S: from bench to stage, from desk to forum
Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/12 - 2017/12 The American Society of Cell Biology (ASCB)/EMBO meeting
Congress
The American Society for Cell Biology, United States

Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
2017/11 - 2017/11 6th I3S annual meeting
Conference
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/06 - 2017/06 Symposium “Forces in Cell Biology”
Symposium
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2017 Scientific Writing Training Module
Workshop
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/11 - 2016/11 5th I3S annual meeting
Conference
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/09 - 2015/09 10th Young European Scientist Meeting
Meeting
Universidade do Porto Faculdade de Medicina, Portugal
2015/05 - 2015/05 IJUP’15 – 8º Encontro de Jovens Investigadores da Universidade do Porto
Meeting
Universidade do Porto, Portugal
2015/05 - 2015/05 Conferências em Oncobiologia
Seminar
Universidade do Porto Faculdade de Farmácia, Portugal
2015/05 - 2015/05 XXIII Porto Cancer Meeting: Stem Cells and Cancer
Conference
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2015/03 - 2015/03 Encontro Nacional de Pós-Graduação em Ciências Biológicas
Meeting
Universidade de Aveiro, Portugal
2015/03 - 2015/03 Introduction to EndNote X7: from a library creation to the writing of a document
Workshop
Universidade do Porto Bibliotecas, Portugal
2015/02 - 2015/02 Teaming Up Against Cancer
Conference
Universidade do Porto Faculdade de Medicina, Portugal
2015/02 - 2015/02 Introduction to Scientific Articles Writing
Workshop
Universidade do Porto Bibliotecas, Portugal
2015/01 - 2015/01 Pubmed: search for subject, limit results, obtain full-text of scientific articles
Workshop
Universidade do Porto Bibliotecas, Portugal
2014/04 - 2014/04 Nobel Day @ CHUC
Conference
Centro Hospitalar e Universitario de Coimbra EPE Campus dos Hospitais da Universidade de Coimbra, Portugal
2014/03 - 2014/03 Workshop “Células Estaminais: da investigação básica à aplicação terapêutica”
Workshop
Centro de Sangue e da Transplantação de Coimbra, Portugal
2014/02 - 2014/02 Speed Dating with Cancer: basic biology and beyond
Conference
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/11 - 2012/11 VI Congresso Anual – Imunologia, Doenças Imunológicas e Imunoterapias
Congress
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/11 - 2012/11 Workshop “Biologia Molecular na Farmacogenética” - XII Jornadas de Análises Clínicas e Saúde Pública
Workshop
Universidade de Coimbra, Portugal
2012/05 - 2012/05 PharmCareer Workshop
Workshop
Universidade de Coimbra Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2025/09/10 Consumo Combinado De Etanol e Imipramina: Efeitos Tóxicos No Modelo Animal C. elegans
Supervisor
 Patrícia Alexandra de Paiva Gonçalves (Other)
Instituto Universitário de Ciências da Saúde, Portugal
2025/07/17 Toxicological interactions of ethanol and synthetic cathinones in the C. elegans animal model
(Thesis) Main arguer
 Tatiana Sousa Moyisyeyenko (Other)
Instituto Universitário de Ciências da Saúde, Portugal
2024/07/24 Efeitos da catinona sintética 4-Metiletilcatinona no desenvolvimento, comportamento reprodutor e longevidade do modelo animal C. elegans
(Thesis) Main arguer
 Daniela Alexandra Coelho Maia (Other)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal
2022/07/01 Actin Cross-linker Interplay in Sarcomeres and Impact in Muscle Disease
(Thesis) Main arguer
 Inês Lima Carvalho (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Committee member

Activity description
Role 		Institution / Organization
2024/10/16 - 2024/10/16 Member of the Scientific Commitee of the VI PhD Day IUCS 2024
Member
 Instituto Universitário de Ciências da Saúde, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2025/09 - Current Phytomedicine Elsevier
2025/06 - Current jcm-3682392 MDPI
2025/05 - Current life-3562643 MDPI
2025/01 - Current ijms-3414834 MDPI
2024/11 - Current medicina-3288246 MDPI
2024/04 - Current Frontiers in Cell and Developmental Biology Frontiers
Distinctions

Award

2024 Annual scientific productivity award
Instituto Universitário de Ciências da Saúde, Portugal
2011 Prémio 3% dos Melhores Estudantes
Universidade de Coimbra, Portugal

Other distinction

2017 Bolsa de Doutoramento FCT
Fundação para a Ciência e a Tecnologia, Portugal
2016 Bolsa de Investigação de Mestre (BIM)
European Research Council, Belgium

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto de Biologia Molecular e Celular, Portugal
2003 Menção Honrosa Melhores Estudantes