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Joana Ribeiro Guedes. Completed the Doutoramento in PhD programme in Experimental Biology and Biomedicine in 2015/12/22 by Universidade de Coimbra, Mestrado in Master¿s Degree in Biochemistry in 2011/07/21 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and Licenciatura in Bachelor degree in Biochemistry in 2009 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia. Is Postdoc in Centro de Inovação em Biomedicina e Biotecnologia (CIBB). Published 17 articles in journals. Has 3 section(s) of books. Organized 7 event(s). Participated in 7 event(s). Co-supervised 1 PhD thesis(es). Supervised 1 MSc dissertation(s). Has received 7 awards and/or honors. Participates and/or participated as Post-doc in 2 project(s), Post-doc Fellow in 1 project(s), Principal investigator in 1 project(s) and Researcher in 2 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Health Sciences. In their professional activities interacted with 201 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Neuroimmunology; Neuropsychiatric diseases; Microglia; Neuronal circuits; Electrophysiology; Alzheimer's disease; miRNAs; microglia; monocytes; Early-life stress; social hierarchy; Neuronal circuits; Optogenetics; Gene Therapy; Microglia: ; Cerebellum; Ageing; Biomarkers; Inflammation; Chemokine receptors; miRNA; Inflammation; Monocytes; Macrophages; Phagocytosis; Chemotaxis; Liposomes; Exosomes; Lipids; Gene therapy; Nanotecnhology; miR-155; astrocytes; Autism; GPRASP2; behavior; synaptic pruning; immune response; neurodevelopment; neuroinflammation; Brain organoids; Dental stem cells; Alzheimer; Viral vectors; Therapeutics; miR-31; Hippocampus; Behavior; APP; BACE1; iPSCs; CRISPR/Cas9; Neurodevelopment diseases; Intellectual disability; stargazin; AMPAR; Glioblastoma; Extracellular vesicles; MIcroglia; IL-4; cerebellum; ADHD; allergies; autism; parvalbumin neurons; microgla; aging; .
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Identification

Personal identification

Full name
Joana Ribeiro Guedes

Citation names

  • Guedes, J. R.

Author identifiers

Ciência ID
8C19-B3B7-13E3
ORCID iD
0000-0001-9054-1887
Google Scholar ID
Gb-LU6oAAAAJ&hl
Researcher Id
N-1866-2015

Email addresses

  • joana.guedes@cnc.uc.pt (Professional)
  • joana.guedes@uc.pt (Professional)

Telephones

Telephone
  • 239820190 (Professional)

Addresses

  • Center for Neuroscience and Cell Biology, University of Coimbra. Rua Larga Faculty of Medicine, Pólo I, 2nd floor Lab205B, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2015/12/22
Concluded
 PhD programme in Experimental Biology and Biomedicine (Doutoramento)
Major in Neurobiology of Disease
Universidade de Coimbra, Portugal
"Inflammation in Alzheimer’s disease: deregulation and modulation of miRNA expression in the mononuclear phagocyte system" (THESIS/DISSERTATION)
 Approved unanimously, with Distinction and Honors
2011/07/21
Concluded
 Master’s Degree in Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Evaluation of miR-155 and miR-125b regultory effect in astrocyte-mediated immune response" (THESIS/DISSERTATION)
 19
2009
Concluded
 Bachelor degree in Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"TLR-dependent microglia activation and miRNA deregulation in Alzheimer's disease" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2023/07/19 - Current Researcher (Research) Universidade de Coimbra, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2023/02/07 - 2023/07/18 Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/04/01 - 2023/02/06 Postdoc (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/05 - 2019/05 Visiting Researcher (Research) Johannes Gutenberg Universität Mainz, Germany
2016/06/01 - 2017/03/31 Postdoc (Research) CNC.IBILI, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020/09/01 - 2021/02/06 Invited Assistant Professor (University Teacher) Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Others

Category
Host institution 		Employer
2011/09/01 - 2015/12/22 PhD student CNC.IBILI, Portugal
2014/06/03 - 2015/04/14 Graduate Student Researcher Massachusetts General Hospital, United States
Projects

Grant

Designation Funders
2023/03/01 - Current 10.54499/2022.02604.PTDC
10.54499/2022.02604.PTDC
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/02/01 - Current Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies
PTDC/MED-NEU/5993/2020
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/03/01 - 2023/06/01 BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids
EXPL/MED-OUT/1470/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2019 The influence of maternal bonding in microglia-mediated synaptic pruning
Fundação Bial 264/2016
Post-doc
CNC.IBILI, Portugal
 Bial
Ongoing
2016 - 2019 Early-life stress and social hierarchies: the role of cortico-striatal circuits
Fundação Bial 266/2016
Post-doc
CNC.IBILI, Portugal
 Bial
Ongoing
2016/06 - 2017/03 Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation
PTDC/NEU-SCC/3247/2014
Post-doc Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2013 - 2016 Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
PTDC/BIM-MEC/0651/2012
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Cardoso, Ana L.; Guedes, Joana R.. "Quantifying miRNA Deregulation in Alzheimer’s Disease". In Biomarkers for Alzheimer’s Disease Drug Development, 307-319. Springer New York, 2018.
    Published • 10.1007/978-1-4939-7704-8_21
  2. Cardoso, A.M.; Guedes, J.R.; Cardoso, A.L.; Morais, C.; Cunha, P.; Viegas, A.T.; Costa, R.; Jurado, A.; Pedroso de Lima, M.C.. "Recent Trends in Nanotechnology Toward CNS Diseases: Lipid-Based Nanoparticles and Exosomes for Targeted Therapeutic Delivery.". In International Review of Neurobiology, 1-40. London: Elsevier, 2016.
    10.1016/bs.irn.2016.05.002
  3. Guedes, J. R.; Viegas, A. T.; Pedroso de Lima, M. C.; Cardoso, A. L.. "Microglia: A Double-Edged Sword for Alzheimer’s Disease". In Microglia: Physiology, Regulation and Health Implications, 1-66. New York: Nova Science Publishers, 2015.
    Published
Conference paper
  1. Costa, J. M.; Guedes, J. R.; Franco, L.; Peça, J.; Cardoso, A. L.. "Microglia morphology and density analysis: using stereology and 3D reconstruction to study the neuroimmune impact of early life stress". Paper presented in 52th International Congress on Microscopy and Microanalysis, Coimbra, 2018.
    10.1109/wccct.2014.15
  2. Viegas, A. T.; Carmona, V.; Guedes, J.R.; de Almeida, L. P.; Oliveira, C. R.; Magalhães, J.; Peça, J.; Cardoso, A. L.. "MicroRNA contribution in a new therapeutic strategy for Alzheimer’s disease". Paper presented in The 2016 Alzheimer’s Disease Congress, London, 2016.
  3. Guedes, J.; de Almeida, L. P.; Pedroso de Lima, M. C.; Cardoso, A. L.. "Upregulation of c-Jun in the 3xTrg AD model regulates miR-155 expression in glial cells and contributes to neuroinflammation.". Paper presented in XI European Meeting on Glial Cells in Health and Disease, Berlim, 2013.
    Published
  4. Guedes, J.; de Almeida, L. P.; Pedroso de Lima, M. C.; Cardoso, A. L.. "MiR-155 silencing decreases neuroinflamation in Aß-stressed astrocytes and microglia". Paper presented in ESGCT 20th Anniversary Congress in Collaboration with the SFTCG, Versailles, 2012.
    Published
Conference poster
  1. Guedes, J. R.; Ferreira, P.A.; Costa, J.; Laranjo, M.; Pinto, M. J.; Reis, T.; Cardoso, A. M.; et al. "IL-4 and allergies shape microglia-dependent pruning of the cerebellum during postnatal development". Paper presented in British Society of Immunology Congress 2023, 2023.
  2. Laranjo, M.; Reis, T.; Guedes, J. R.; Gomes, M.; Pereira, M.; Cammarata, G,; Edfawy, M.; Cardoso, A. L.; Peça, João. "Conditional deletion of Gprasp2 in PV-positive neurons drives hippocampal circuit alterations and cognitive dysfunction,". Paper presented in FENS Regional Meeting, 2023.
  3. Laranjo, M.; Guedes, J. R.; Reis, T.; Gomes, M.; Pereira, M.; Cammarata, G,; Edfawy, M.; Cardoso, A. L.; Peça, João. "Conditional deletion of Gprasp2 in PV-positive neurons drives hippocampal circuit alterations and cognitive dysfunction". Paper presented in 8th European Synapse Meeting, 2022.
  4. Oliveira, A. R.; Cammarata, G.; Cardoso, A. M.; Seabra, C. M.; Guedes, J. R.; Cardoso, A. L.; Fernandes, D.; et al. "Autism associated CASPR2 auto-immune antibodies modify the developmental trajectory and network activity in human brain organoids". Paper presented in FENS Forum 2022, 2022.
  5. Guedes, J. R.; Ferreira, P.A.; Costa, J.; Laranjo, M.; Reis, T.; Cardoso, A. M.; Lebre, C.; et al. "Allergies and IL-4 shape postnatal cerebellar development via microglia-mediated neuronal pruning to induce ADHD-like behaviors in mice". Paper presented in FENS Forum 2022, 2022.
  6. Ferreira, P.A.; Guedes, J. R.; Reis, T.; Costa, J.; Cardoso, A. L.; Peça, João. "Postnatal L-4 administration induces long-term dysfunction in cerebellar-VTA connectivity". Paper presented in FENS Forum 2022, 2022.
  7. Seabra, C. M.; Martins, M.; Oliveira, A. R.; Cammarata, G,; Martins, S.; Perdigão, P.; Guedes, J. R.; et al. "Braincils: Exploring the missing link between neuronal primary cilia dysfunction and neurodevelopmental disorders - hints from dental stem cell-derived brain organoids". Paper presented in FENS Forum 2022, 2022.
  8. Costa, J.; Martins, S.; Kunicki, C.; Ferreira, P.A.; Guedes, J. R.; Peça, João; Cardoso, A. L.. "Early-life adversity induces sex-specific dysfunction of the mOFC and leads to impulsive, hyperactive, and risk-taking behaviors in juvenile male mice". Paper presented in FENS Forum 2022, 2022.
  9. Cardoso, A. L.; Costa, J.; Martins, S.; Kunicki, C.; Ferreira, P.A.; Guedes, J. R.; Peça, João. "Exposure to early-life stress promotes sex-dependent changes in microglia morphology and phagocytic activity in the prefrontal cortex". Paper presented in FENS Forum 2022, 2022.
  10. Laranjo, M.; Guedes, J. R.; Gomes, M.; Pereira, M.; Reis, T.; Cammarata, G.; Edfawy, M.; Cardoso, A. L.; Peça, João. "Conditional deletion of Gprasp2 in PV-positive neurons drives hippocampal circuit alterations and cognitive dysfunction". Paper presented in FENS Forum 2022, 2022.
  11. Laranjo, M.; Guedes, J. R.; Gomes, M.; Pereira, M.; Reis, T.; Cammarata, G.; Edfawy, M.; Cardoso, A. L.; Peça, João. "Conditional deletion of Gprasp2 in PV-positive neurons drives hippocampal circuit alterations and cognitive dysfunction". Paper presented in ENCODS 2022, 2022.
  12. Martins, M.; Oliveira, A. R.; Cammarata, G.; Martins, S.; Perdigão, P.; Guedes, J. R.; Cardoso, A. L.; et al. "BrainCils: Exploring the missing link between neuronal primary cilia dysfunction and neurodevelopmental disorders - hints from dental stem cell-derived brain organoids". Paper presented in Cell Symposia: The Biology of Neuropsychiatric Disorders, 2022.
  13. Martins, M.; Oliveira, A. R.; Cammarata, G.; Martins, S.; Perdigão, P.; Guedes, J. R.; Cardoso, A. L.; et al. "Exploring the missing link between primary cilia and neurodevelopmental disorders: The case of a novel MBD5 variant in a patient with severe epilepsy". Paper presented in CIBB Neuroscience & Disease Retreat, 2022.
  14. Laranjo, M.; Guedes, J. R.; Gomes, M.; Pereira, M.; Reis T.; Cammarata, G.; Edfawy, M.; Cardoso , A. L.; Peça, João. "Conditional deletion of Gprasp2 in PV-positive neurons drives hippocampal circuit alterations and cognitive dysfunction.". Paper presented in Meeting of the BEB students - BEBDay 2022, 2022.
  15. Guedes, J. R.; Ferreira, P.A.; Costa. J.; Laranjo, M.; Reis, T.; Cardoso, A.M.; Gomes, M.; et al. Corresponding author: Peça, João. "Abnormal microgia-mediated pruning in the cerebellum induces circuitry and behavioral dysfunction in mice". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  16. Oliveira, A. R.; Seabra, C. M.; Guedes, J. R.; Cammarata, G.; Cardoso, A. M.; Fernandes, D.; Coutinho, E.; et al. "Uncovering the neurodevelopmental consequences of anti-CASPR2 antibody exposure in 3D brain organoids". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  17. Caldeira, G. L.; Inácio, A. S.; Beltrão, Nuno; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, Tiago; Macedo, R.; et al. "Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  18. Laranjo, M.; Guedes, J. R.; Pereira, M.; Gomes, M.; Reis, T.; Cammarata, G.; Edfawy, M.; Cardoso, A. L.; Peça, João. "Dissecting the role of parvalbumin-positive inhibitory neurons in the cellular and behavioural phenotypes associated with Gprasp2 deletion". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  19. Reis, T.; Guedes, J. R.; Peça, João; Ferreira, L.. "ChuTe - Cellular homing using TRPV channel expression for thermal sensitivity and thermotaxis". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  20. Oliveira, A. R.; Seabra, C. M.; Guedes, J. R.; Cammarata, G.; Fernandes, D.; Coutinho, E.; Carvalho, A. L.; Ferreira, L.; Peça, J.. "Uncovering the role on immune response in ASD: neurodevelopmental consequences of anti-CASPR2 antibodies exposure in 3D brain organoids". Paper presented in Organoids: Modelling Organ Development and Disease in 3D Culture - Virtual, 2020.
  21. Peça, João; Laranjo, M.; Edfawy, Mohamed; Guedes, J. R.; Carvalho, M.; Gomes, M.; Pereira, M. I.. "Conditional deletion of Gprasp2 in PV-positive interneurons leads to selectively behavioural and circuit dysfunction". Paper presented in 2020 FENS Virtual Forum, 2020.
  22. Cardoso, A. L.; Costa, J. M.; Oliveira, S.; Ferreira, P.A.; Guedes, J. R.; Carvalho, M.; Peça, João. "Early-life stress causes sex-dependent changes in microglia function, circuit wiring and behavior in the PFC". Paper presented in 2020 FENS Virtual Forum, 2020.
  23. Seabra, C. M.; Oliveira, A. R.; Guedes, J. R.; Cardoso, A. L.; Sequeira, D. B.; Palma. P. J.; Santos, J. M.; et al. "Modeling the neurogenetics of neurodevelopmental disorders - hints from brain organoids.". Paper presented in Annual Meeting of the Human Genetics Society, 2019.
  24. Oliveira, A. R.; Seabra, C. M.; Guedes, J. R.; Ferreira, L.; Peça, J.. "Mini-brains on a dish: Characterization of autism susceptibility genes using iPSCs and CRISPR/Cas9 gene engineering". Paper presented in 11th meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2019.
    10.18699/plantgen2019-099
  25. Rebelo, C.; Pinho, S.; Reis, T.; Saraiva, C.; Guedes, J. R.; Bernardino, L.; Peça, J.; Ferreira, L.. "Coupling Near-infrared Light Triggerable Delivery of Cre Recombinase With Optogenetics To Control Brain Activity". Paper presented in 46th Controlled Release Society Annual Meeting & Exposition (Valencia, Spain), 2019.
  26. Inácio, A.; Caldeira, G.; Louros, S. R.; Rondão, T.; Beltrão, N.; Rodrigues, M. V.; Guedes, J. R.; Peça, J.; Carvalho, A. L.. "Neuronal dysfunction and behaviour abnormalities in mice with stargazin mutation linked to intellectual disability". Paper presented in FENS Regional Meeting, 2019.
  27. Costa, J.; Guedes, J. R.; Ferreira, P.A.; Franco, L.; Peça, J.; Cardoso, A. L.. "Early-life stress causes behaviour changes and microglia dysfunction in the pre-frontal cortex of male mice". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  28. Rebelo, C.; Pinho, S.; Reis, T.; Saraiva, C.; Guedes, J. R.; Bernardino, L.; Peça, J.; Ferreira, L.. "NIR-light dependent delivery of Cre recombinase: an optogenetic tool for DNA modulation in the brain". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019.
  29. Guedes, J. R.; Ferreira, P.A.; Pereira, M. I; Costa, J.; Cardoso, A. L.; Peça, J.. "IL-4 skews the microglial developmental program during cerebellar maturation". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  30. Seabra, C. M.; Oliveira, A. R; Guedes, J. R.; Sequeira, D. B.; Palma, P. J; Santos, J. M.; Duque, F.; et al. "Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopment disorders". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  31. Guedes, J.R.; Pedro, P.A; Costa, J.; Pereira, M.; Cardoso, A.L.; Peça, J.. "Microglia-dependent remodeling of cerebellar circuits". Paper presented in Gordon Research Conference - Neuroimmune Communication in Health and Disease, Exploring Neuroimmunology: From Single Cells to Organisms, 2019.
  32. Caldeira, G.; Louros, S. R.; Inácio, A.; Rondão, T.; Beltrão, N.; Rodrigues, M. V.; Guedes, J. R.; Peça, J.; Carvalho, A. L.. "Aberrant hippocampal transmission and cognitive behavior in mice with stargazin mutation linked to intellectual disability.". Paper presented in 11th FENS Forum of Neuroscience, 2018.
  33. Viegas, A. T.; Carmona, V.; Guedes, J. R.; de Almeida, L. P.; Oliveira, C. R.; Magalhães, J.; Peça, J.; Cardoso, A. L.. "MicroRNA modulation targets amyloid-ß cascade and cognitive function in Alzheimer's Disease". Paper presented in 10th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, 2016.
  34. Viegas, A. T.; Carmona, V.; Guedes, J. R.; de Almeida, L. P.; Oliveira, C. R.; Magalhães, J.; Peça, J.; Cardoso, A. L.. "MicroRNA modulation targets amyloid-ß cascade and cognitive function in Alzheimer's Disease". Paper presented in The 4th International Conference on Molecular Neurodegeneration (ICMN 2016): Novel Systems and Emerging Concepts, 2016.
  35. Guedes, J.; Santana, I.; Cunha, C.; Almeida, R.; Cardoso, A.M.; Pedroso de Lima, M. C.; Cardoso, A. L.. "Molecular and phenotypic alterations in the mononuclear phagocyte system from Alzheimer's disease patients". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  36. Guedes, J.; Custodia, C. M.; Silva, R. J.; de Almeida, L. P.; Pedroso de Lima, M. C.; Cardoso, A. L.. "MiR-155 silencing decreases neuroinflammation in activated microglia and astrocytes". Paper presented in EMBO Young Scientists’ Forum 2013, 2013.
  37. Guedes, J.R.; Custodia, C. M.; Silva, R. J.; de Almeida, L. P.; Pedroso de Lima, M. C.; Cardoso, A. L.. "MiR-155 silencing decreases neuroinflammation in activated microglia and astrocytes". Paper presented in Coimbra Innate Immunity SPI Workshop, 2012.
  38. Cardoso, A. L.; Guedes, J. R.; Luís Pereira de Almeida; de Lima, Maria C. Pedroso. "Deregulation of immune-related miRNAs in Alzheimer’s disease". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2011.
Journal article
  1. Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Pinto, Maria J.; Reis, Tiago; Cardoso, Ana Maria; et al. "IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development". Neuron 111 21 (2023): 3435-3449.e8. http://dx.doi.org/10.1016/j.neuron.2023.09.031.
    10.1016/j.neuron.2023.09.031
  2. Catarina Rebelo; Tiago Reis; Joana Guedes; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al. "Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications". Nature Communications (2022): https://doi.org/10.1038/s41467-022-31791-6.
    10.1038/s41467-022-31791-6
  3. Guedes, J. R.; Ferreira, P.A.; Costa, Jéssica M.; Cardoso, Ana L.; Peça, João. "Microglia-dependent remodeling of neuronal circuits". Journal of Neurochemistry (2022): http://dx.doi.org/10.1111/jnc.15689.
    10.1111/jnc.15689
  4. Caldeira, G. L.; Inácio, A. S.; Beltrão, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, T.; Macedo, R.; et al. "Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". Molecular Psychiatry (2022): http://dx.doi.org/10.1038/s41380-022-01487-w.
    10.1038/s41380-022-01487-w
  5. Costa, Jéssica; Martins, Solange; Ferreira, Pedro A.; Cardoso, Ana M.S.; Guedes, Joana R.; Peça, João; Cardoso, Ana L.. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512. http://dx.doi.org/10.1016/j.mad.2021.111512.
    10.1016/j.mad.2021.111512
  6. Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Edfawy, Mohamed; et al. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". Neuropsychopharmacology (2020): http://dx.doi.org/10.1038/s41386-020-0727-7.
    10.1038/s41386-020-0727-7
  7. Maas, Sybren L. N.; Abels, Erik R.; Van De Haar, Lieke L.; Zhang, Xuan; Morsett, Liza; Sil, Srinjoy; Guedes, J. R.; et al. "Glioblastoma hijacks microglial gene expression to support tumor growth". Journal of Neuroinflammation 17 1 (2020): http://dx.doi.org/10.1186/s12974-020-01797-2.
    10.1186/s12974-020-01797-2
  8. Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cunha, Pedro; Pereira de Almeida, Luís; Resende de Oliveira, Catarina; et al. "MiRNA-31 improves cognition and abolishes amyloid-ß pathology by targeting APP and BACE1 in an animal model of Alzheimer’s disease". Molecular Therapy - Nucleic Acids (2020): http://dx.doi.org/10.1016/j.omtn.2020.01.010. IF=5.919.
    10.1016/j.omtn.2020.01.010
  9. Mohamed Edfawy; Joana R. Guedes; Marta I. Pereira; Mariana Laranjo; Mário J. Carvalho; Xian Gao; Pedro A. Ferreira; et al. "Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice". Nature Communications (2019): https://doi.org/10.1038/s41467-019-09382-9. IF=11.878.
    10.1038/s41467-019-09382-9
  10. Cardoso, Ana Luisa; Fernandes, Adelaide; Aguilar-Pimentel, Juan Antonio; de Angelis, Martin Hrabe; Guedes, Joana Ribeiro; Brito, Maria Alexandra; Ortolano, Saida; et al. "Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases". Ageing Research Reviews 47 (2018): 214-277. http://dx.doi.org/10.1016/j.arr.2018.07.004. IF=10.39.
    Published • 10.1016/j.arr.2018.07.004
  11. Guedes, Joana R.; Lao, Taotao; Cardoso, Ana L.; El Khoury, Joseph. "Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-ß and Tau Pathologies". Frontiers in Neurology 9 (2018): http://dx.doi.org/10.3389/fneur.2018.00549. IF=2.635.
    Published • 10.3389/fneur.2018.00549
  12. Viegas, A.T.B.; Guedes, J.R.; Oliveira, A.R.; Cardoso, A.M.S.; Cardoso, A.L.C.. "miRNAs: New biomarkers and therapeutic targets in dementia". Current Pharmaceutical Design 23 5 (2017): 669-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017530528&partnerID=MN8TOARS. IF=2.412.
    Published • 10.2174/1381612823666170111094702
  13. Cardoso, Ana L*; Guedes, Joana R*; de Lima, Maria C Pedroso; *equal contribution. "Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions". Current Opinion in Pharmacology 26 (2016): 1-9. http://dx.doi.org/10.1016/j.coph.2015.09.001. IF=5.203.
    Published • 10.1016/j.coph.2015.09.001
  14. Guedes, Joana R.; Santana, Isabel; Cunha, Catarina; Duro, Diana; Almeida, Maria R.; Cardoso, Ana M.; de Lima, Maria C. Pedroso; Cardoso, Ana L.. "MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease". Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 3 (2016): 7-17. http://dx.doi.org/10.1016/j.dadm.2015.11.004. IF=5.28.
    10.1016/j.dadm.2015.11.004
  15. Guedes, Joana R.; Custódia, Carlos M.; Silva, Ricardo J.; de Almeida, Luís P.; Pedroso de Lima, Maria C.; Cardoso, Ana L.. "Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model". Human Molecular Genetics 23 23 (2014): 6286-6301. http://dx.doi.org/10.1093/hmg/ddu348. IF=4.544.
    10.1093/hmg/ddu348
  16. Guedes, J.; Cardoso, A. L. C.; Pedroso de Lima, M. C.. "Involvement of MicroRNA in Microglia-Mediated Immune Response". Clinical and Developmental Immunology 2013 (2013): 1-11. http://dx.doi.org/10.1155/2013/186872. IF=3.603.
    Published • 10.1155/2013/186872
  17. Cardoso, A. L.; Guedes, J. R.; de Almeida, L. P.; Pedroso de Lima, M. C.. "miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production". Immunology 135 1 (2012): 73-88. 10.1111/j.1365-2567.2011.03514.x. IF=4.147.
    Published • 10.1111/j.1365-2567.2011.03514.x
Newspaper article
  1. Guedes, J. R.; Ferreira, P.A.; Shkatova, V.; Pedroso, S.; Cerejeira, Joaquim; Cardoso, A. L.; Peça, João. "O que é a perturbação de hiperactividade e défice de atenção? Serão só bichos-carpinteiros?", Público, 2021, https://www.publico.pt/2021/05/19/ciencia/noticia/perturbacao-hiperactividade-defice-atencao-serao-so-bichoscarpinteiros-1962657.
Thesis / Dissertation
  1. Guedes, Joana Ribeiro. "Inflammation in Alzheimer's disease: deregulation and modulation of miRNA expression in the mononuclear phagocyte system". PhD, Universidade de Coimbra Instituto de Investigação Interdisciplinar, 2015. http://hdl.handle.net/10316/29539.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/12/20 IL-4 and allergies shape microglia-dependent pruning of the cerebellum during postnatal development CIBB meeting 2023
Center for Innovative Biomedicine and Biotecnhology (Coimbra, Portugal)
2023/12/07 Time as a variable: IL-4 defines a critical window of cerebellar postnatal development British Society of Immunology Congress 2023
British Society for Immunology (Belfast, United Kingdom)
2023/01/31 IL-4 and allergies shape microglia-dependent pruning of the cerebellum during postnatal development Development and neurological disease Abcam Seminars
Abcam
2023/01/19 IL-4 and allergies shape microglia-dependent pruning of the cerebellum during postnatal development Manchester Immunology Seminar Series
British Society for Immunology (Manchester, United Kingdom)
2022/12/20 IL-4 and allergies shape microglia-dependent pruning of the cerebellum during postnatal development Seminário Ciências Biomédicas
Universidade do Algarve (Portugal)
2022/09/14 How does the neuroimmune system influence neurodevelopment? Lab Talks, Master in Cellular and Molecular of the Department of Life Sciences of the University of Coimbra
Department of Life Sciences, University of Coimbra (Coimbra, Portugal)
2022/07/07 Allergies and IL-4 shape postnatal cerebellar development via microglia-mediated neuronal pruning to induce ADHD-like behaviors in mice Neurasmus Annual Meeting
Department of Life Sciences, University of Coimbra (Coimbra, Portugal)
2019/05/29 IL-4 skews the microglial developmental program during cerebellar maturation IV Symposium Glia Diversity in Neuromodulation and Neurodegeneration
Rede Glial (Lisbon, Portugal)
2016/06/07 MicroRNA contribution in a new therapeutic strategy for Alzheimer's disease The 2016 Alzheimer's Disease Congress
British Society for Genetic Medicine (London, United Kingdom)
2014/12 Molecular and phenotypic alterations in the mononuclear phagocyte system from Alzheimer's disease patients XII CNC Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2014/05/26 MicroRNAs and their therapeutic potential in Alzheimer's disease Baku World Forum of Young Scientists 2014
(Baku, Azerbaijan)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/10/01 - Current Cellular and molecular mechanisms behind allergy-induced Attention-Deficit/Hyperactivity Disorder
Co-supervisor
 Doctoral Programme in Biomedicine and Experimental Biology (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/09/04 - Current Characterization of cerebellar pruning and microglia function in IL-4 receptor deficient mice
Supervisor
 Master's in Molecular and Cellular Biology (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/09/04 - Current Inhibitory synaptic alterations in neuroimmune insults mediated by IL-4
Co-supervisor
 Master's in Molecular and Cellular Biology (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/10 - Current Unraveling the role of IL-4 in the maturation and function of the cerebellar circuit: implications for neuropsychiatric diseases
Co-supervisor
 Doctoral Programme in Biosciences (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/09 - 2022/09 The impact of postnatal allergies in microglia-mediated cerebellar maturation
Supervisor
 Master in Cellular and Molecular Biology (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/11/30 - 2021/11/30 V Symposium of the Portuguese Glial Network 2021: Glial cells at the crossroad of health and disease (2021/11/30)
Meeting (Co-organisor)
 Rede Glial Portugal, Portugal
2018 - 2018 Biomedical Research Post-Doctoral Forum @UC "Overcoming Challenges in Scientific Careers" aimed at creating an opportunity for PhD holders and PhD students to reflect on their career paths and make informed choices, by contacting and hearing from people of diverse scientific backgrounds. (2018 - 2018)
Symposium (Member of the Organising Committee)
 CNC.IBILI, Portugal
2013 - 2013 1st reSEARCH Coimbra in Health Sciences
Congress (Other)
 1st reSEACRH Coimbra Association, Portugal
2013 - 2013 1st BEB Symposium “Science dreams, challenges arise”
Symposium (Other)
 CNC/UC, Portugal
2013 - 2013 2º Fórum Anual de Graduados Portugueses no Estrangeiro
Other (Other)
 PAPS, PARSUK, AGRAFr, Portugal
2013 - 2013 XI Annual Meeting CNC
Meeting (Other)
 CNC/UC, Portugal
2009 - 2009 Jornadas Pedagógicas do NEBIOQ/AAC
Seminar (Other)
 NEBIOQ/AAC, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/09/29 - Current European Reseacher's Night 2023. This is a science communication activity in which we presented our stand entitled AAAtchimmm: Attention., Alergies and Atopy
Exhibition
 European Reseacher's Night 2023
Universidade de Coimbra, Portugal
2022/03/21 - 2022/03/21 This activity aimed at explaining the work I perform in the lab to the general public, specific to adolescents (12º grade, Escola Secundária Infanta D. Maria, Coimbra).
Other
 Neurocientistas vão à escola, Brain Awarness Week
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2021/11/09 - 2021/11/09 Information session entitled "Perturbação de Hiperatividade e Défice de Atenção: Trocando por miúdos uma condição neuropsiquiátrica"
Other
 Perturbação de Hiperactividade e Défice de Atenção
Centro Paroquial de Bem Estar Social de Almalaguês, Portugal
2021/04 - 2021/04 Participation in the project "A Saúde no Saber: Desvendar Ciência em menos de 3 minutos", with the theme "Do vaccines cause autism?". This was a project that effectively contributed to the promotion of a scientific culture in Portugal. In this episode we dismistified the idea that vaccines cause autism.
Other
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2019 This activity aimed at explaining the work I perform in the lab to the general public, specific to children.
Exhibition
 Noite Europeia dos Investigadores
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/11/26 - 2018/11/26 This workshop was performed by Megan Carey and Kamran Khodakhah, two world-renowned scientists on the study of the cerebellum.
Workshop
 I Workshop on the Cerebellum: Motor and Non-Motor Functions
Universidade do Minho Escola de Medicina, Portugal
2017/09 - 2017/09 Modular structure Training in Laboratory Animal Science This was a course focused on the training of scientists to manipulate laboratory animals. Modular structure Training in Laboratory Animal Science
Faculdade de Medicina da Universidade de Coimbra, Portugal
2016 - 2016 This activity aimed at explaining the work I perform in the lab to the general public, specific to children.
Other
 Brain Awareness Week
CNC.IBILI, Portugal
2012 - 2012 The ibidi course was a pratical course focused on the use of microfluidic chambers to evaluate chemotaxis.
Workshop
 ibidi Course - Chemotaxis Assays and Video Microscopy
ibidi GmbH , Germany

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/09 Inflammatory mechanisms of blood-brain-barrier damage in drug abuse: focus on CCL5-CXCR5 axis
(Thesis) Main arguer
 Ana Olívia Fernandes (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/06/13 Collateral flow as a predictor for angiogenesis in middle cerebral artery ischemic stroke
(Thesis) Arguer
 Mariia Ermolaeva (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2022/09 Anatomical characterization and behavioral consequences of manipulating VTA glutamateregic neurons projecting to anxiety centers
(Thesis) Main arguer
 Carolina Nabais (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022/09 The impact of postnatal allergies in microglia-mediated cerebellar maturation
Supervisor
 Maria Casquinha (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/12 Dynamics of motor memory consolidation in the cerebellum
(Thesis) Main arguer
 Inês Ribeiro (Master)
Fundação Champalimaud, Portugal
2017/09 Cell type-specific drivers to study the Dilp8-sensitive neuroendocrine circuit
(Thesis) Main arguer
 Joana Pereirinha (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Association member

Society Organization name Role
2019/05 - Current Portuguese Society for Neuroscience
2013/06 - Current Portuguese-American Post-graduate Society
2011/09 - 2021/01/31 reSEARCH Coimbra

Committee member

Activity description
Role 		Institution / Organization
2017 - 2019 Representative of post-doctoral researchers of CNC.IBILI
Member
 CNC.IBILI, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/02/23 - Current Microglia mediate IL-4-induced cerebellar alterations and hyperactivity in mice. Master in Molecular and Translational Neuroscience (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2022/12/12 - Current Fisiologia Celular - Técnicas de electrofisiologia Biologia (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2022/12/07 - Current Fisiologia Celular - Sistema Imunitário Adaptativo Biologia (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018/01/05 - Current Principles of electrophysiology ana data analysis Neuronal Circuits and Behavior (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/01/04 - Current Cerebellar Circuits Neuronal Circuits and Behavior (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/03/06 - 2024/03/17 Neuroimmunology Master in Cellular and Molecular Biology (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2024/02/08 - 2024/02/08 Neuroimmune critical period in cerebellar development. Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2024/02/05 - 2024/02/07 Practical lessons on whole-cell patch clamp Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2023/09/18 - 2023/12/16 Societal Challenges in Health Biologia (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/12/14 - 2023/12/14 Fundamentos em Neurociências (seminário "IL-4 in neurodevelopment") Medicina (Licenciatura) Faculdade de Medicina da Universidade de Coimbra, Portugal
2022/09/01 - 2023/01/31 Biologia Celular e Molecular Engenharia Biomédica e Química medicinal (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/01/25 - 2023/01/25 IL-4 and allergies shape microglia-dependent pruning of the cerebellum during postnatal development (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2021/05/12 - 2021/05/12 Class given to the program Estudo Em Casa developed by the Portuguese Education Ministry in the context of the COVID-19 pandemic. This class was inserted in the discipline Ciências Naturais e Cidadania and was entitled "Doenças e saúde no sistema nervoso". (Ensino básico 3º ciclo)
2020/09/06 - 2021/02/06 Societal Challenges in Health Biology (Licenciatura) University of Coimbra - Departement of Life Sciences, Portugal
2020/09 - 2021/02/06 Biochemistry of Proteins, Nucleic Acids and Lipids Biochemistry (Licenciatura) University of Coimbra - Departement of Life Sciences, Portugal
2020/09 - 2021/02/06 Introduction to the Biochemistry Laboratory Biochemistry (Licenciatura) University of Coimbra - Departement of Life Sciences, Portugal
2020/11/20 - 2020/11/20 Deregulation of metabotropic glutamate receptor-dependent synaptic plasticity as a common mechanism in autism spectrum disorder. Master in Research Methods and Tecnhiques (Mestrado) Faculdade de Medicina da Universidade de Coimbra, Portugal
2018 - 2018 Electrophysiology - Measurement of synaptic parameters in rat hippocampal slices and in cultured rat hippocampal neurons Synapses, Neuronal Circuits and Behavior - Supported by FENS/IBRO-PERC (Doutoramento) CNC.IBILI, Portugal
2016 - 2016 Microglia in health, development and adulthood Neurodevelopmental Disorders (Doutoramento) CNC.IBILI, Portugal

Interview (tv / radio show)

Program Topic
2022/03/18 - 2022/03/18 Observatório - Rádio Universidade de Coimbra Neuroimmune remodeling of neuronal circuits

Journal scientific committee

Journal title (ISSN) Publisher
2023/08 - Current Frontiers in Cellular Neuroscience
2023/01 - Current Frontiers in Neural Circuits
2016 - 2016 Neuroscience (0306-4522) Elsevier
2015 - 2015 PLoS ONE (1932-6203) Public Library of Science

Mentoring / Tutoring

Topic Student name
2024/03/25 - Current Allergies as a risk factor for ADHD Diogo Pereira
2024/02/03 - 2027/07/03 Filipa Moura Filipa Moura
2024/02/22 - 2024/06/30 Plasticity studies in mice lacking GPRASP2 in parvalbumin-positive neurons Louana Ceiça
2024/02/05 - 2024/06/29 Arginase-1 in the postnatal cerebellum Clara Caetano
2024/03/04 - 2024/04/04 Plasticity studies in mice lacking GPRASP2 in parvalbumin-positive neurons Sylvia Jimenez
2024/02/04 - 2024/03/04 Plasticity studies in mice lacking GPRASP2 in parvalbumin-positive neurons Margaria Guerreiro
2024/01/27 - 2024/02/27 Plasticity studies in mice lacking GPRASP2 in parvalbumin-positive neurons Pedro Lobo
2019/09 - 2023/12 Role of Gprasp2 in the function of parvalbumin-positive neurons Mariana Laranjo
2023/04/04 - 2023/08/31 Neuroimmune remodeling of neuronal circuits Asja Ragnini
2022/09 - 2023/07 Studying the activation of neurons by c-fos staining in IL-4-injected mice following locomotor activity Daniel Marques
2022/09 - 2023/05 The role of cannabinoids in the electrical activity of PFC in Shank3 mouse models Flavio Tomasi
2023/03 - 2023/03 IL-4 influences cerebellar circuit Maria Rosário Ferreira
2021/09 - 2022/09 The influence of allergy mediators in the developmental program of ADHD associated circuits Carolina Lebre
2021/09 - 2022/07 Validating IL-4 as the molecular link beween allergies and ADHD Viktoriya Shkatova
2018 - 2022/07 Uncovering the neurodevelopmental consequences of anti-CASPR2 antibody exposure in 3D brain organoids Ana Rafaela Oliveira
2022/01/04 - 2022/03/31 Neuroimmune remodeling of neuronal circuits Assina Abdussaitova
2022/02 - 2022/02 Neuroimmune remodeling of neuronal circuits Raquel Silva; Alexandra Matos
2021/07 - 2021/07 Neuroimmune remodeling of neuronal circuits Margarida Quadros; Beatriz Santos; Francisca Amaral
2018 - 2019 Microglia-mediated remodelling of cerebellar circuits Pedro Ferreira
2017/09 - 2018/09 The impact of early-life stress throughout life: maternal separation-induced changes in behavior and microglia morphology Jéssica Costa
2017/04 - 2017/06 Environmental autism risk factors to the neuropathology of autism spectrum disorder Camille de Almeida
2017 - 2017 Ex vivo slice electrophysiology José Pedro Sampaio
2017 - 2017 Whole-cell patch clamp in CA1 hippocampal neurons Diogo Passos
2017 - 2017 Studying long-term depression in GPRASP2 KO mice Beatrice Marino
2016 - 2016 Cloning microglia activation-related promoters Teresa Lourenço
2015 - 2015 miRNA and risk gene interactions in Alzheimer's disease: from mechanisms to therapeutics Ana Rafaela Oliveira
2014 - 2014 Quantification of CCR2 and CXCR4 in monocytes from Alzheimer's disease patients Telmo Freitas
2013 - 2013 miR-23a modulates CCR2 expression in THP-1 cells Elvira Leites
Distinctions

Award

2022 Best poster presentation - BEB-Bluepharma Award 2022
Bluepharma, Portugal
2019 Pfizer Award in Basic Research
Pfizer Portugal, Portugal
2019 Honorable Mention in Basic Research from the Annual Meeting of the Human Genetics Society
Sociedade Portuguesa de Genética Humana, Portugal

Title

2015 Ph.D. Magna cum laude
Universidade de Coimbra, Portugal

Other distinction

2022 Travel Grant SPN - FENS Forum 2022
Sociedade Portuguesa de Neurociências, Portugal
2016 Individual 3-year Post-doctoral Fellowship (Ref: SFRH/BPD/120611/2016)
Fundação para a Ciência e a Tecnologia, Portugal
2011 Individual 4-year PhD Fellowship (Ref: SFRH/BD/51677/2011)
Fundação para a Ciência e a Tecnologia, Portugal