Personal identification

Full name

Daniela Filipa Domingues Santo

Date of birth

1993/11/27

Gender

Female

Citation names

• Santo, Daniela

Author identifiers

Ciência ID

8A19-82C0-7D65

ORCID iD

0000-0003-4183-6464

Knowledge fields

• Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
• Medical and Health Sciences - Medical Biotechnology - Biomaterials
• Exact Sciences - Chemical Sciences - Polymer Science
• Engineering and Technology - Materials Engineering - Coating and Films

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)

	Degree	Classification
2017/10 - 2023/07/17 Concluded	Experimental Biology and Biomedicine (specialty in Biotechnology and Health) (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal "Gene therapy mediated by glycopolymers-based nanocarriers in combination with chemotherapeutic drugs as a potential therapeutic strategy for hepatocellular carcinoma " (THESIS/DISSERTATION)
2014/09 - 2017/01 Concluded	Biochemistry (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Avaliação da capacidade de transporte e entrega de material genético associada a diferentes nanossistemas de base polimérica" (THESIS/DISSERTATION)	18
2011/09 - 2014/07 Concluded	Medicinal Chemistry (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal	14

Science

	Category Host institution	Employer
2022/11 - Current	Researcher (Research)	Universidade de Coimbra, Portugal
	Centre for Mechanical Engineering, Materials and Processes, Portugal
2022/04/18 - 2022/10/18	Researcher (Research)	Universidade de Coimbra, Portugal
	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Others

	Category Host institution	Employer
2017/09 - 2023	PhD student	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Contract

	Designation	Funders
2022/11/01 - 2023/06/30	i9LOGO: Inovação no desenvolvimento e produção de Logotipos para o automóvel POCI-01-0247-FEDER-072607 Research Fellow	Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização Concluded
2022/11 - 2023/06/30	ActiveStent Funcionalização Sustentável de Stents para Prevenção de Infeções do Trato Urinário CENTRO-01-0145-FEDER-181221 Other	Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
2022/04/18 - 2022/10/18	Engineering CAR T cells by a cost-effective non-viral gene delivery method BFK2021-APCL Research Fellow	Associação Portuguesa Contra a Leucemia Ongoing
2018/07/01 - 2022/06/30	Desenvolvimento de um nanossistema inovador para mediar uma estratégia terapêutica combinada e multi-alvo para o carcinoma hepatocelular PTDC/BTM-MAT/30916/2017 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/10/01 - 2022/03/31	A novel polymeric micelle formulation to mediate combined immunogene therapy and chemotherapy for hepatocellular carcinoma SFRH/BD/132601/2017 PhD Student Fellow Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Publications

Conference poster	Santo, Daniela; Mendonça, P.; Lima, Mafalda; Cordeiro, Rosemeyre A; Serra, Arménio; Coelho, Jorge FJ; Faneca, Henrique. "Efficient gene delivery promoted byPEGylated poly(2-aminoethyl methacrylate hydrochloride)-basednanosystems". Paper presented in 31st Nano Congress for FutureAdvancements, 2019. Cordeiro, Rosemeyre A; Santo, Daniela; Serra, Arménio; Coelho, Jorge F.J.; Faneca, Henrique. "High gene delivery efficiency of a novel nanosystem based on a synergistic polymeric combination". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, 2018. Santo, Daniela; Cordeiro, Rosemeyre A; Serra, Arménio; Coelho, Jorge FJ; Faneca, Henrique. "High gene delivery efficiency promoted by a combined polymeric-based nanosystem". Paper presented in IEEE 5th Portuguese Meeting on Bioengineering (ENBENG)., 2017.
Journal article	Santo, Daniela; Mendonça, Patrícia; Serra, Arménio C.; Coelho, Jorge; Faneca, Henrique. "Targeted downregulation of MYC mediated by a highly efficient lactobionic acid-based glycoplex to enhance chemosensitivity in human hepatocellular carcinoma cells". International Journal of Pharmaceutics (2023): Under revision Daniela Santo; Patrícia V. Mendonça; Arménio C. Serra; Jorge F.J. Coelho; Faneca H. "Targeted downregulation of MYC mediated by a highly efficient lactobionic acid-based glycoplex to enhance chemosensitivity in human hepatocellular carcinoma cells". International Journal of Pharmaceutics (2023): 122865-122865. http://dx.doi.org/10.1016/j.ijpharm.2023.122865. 10.1016/j.ijpharm.2023.122865 Daniela Santo; Rosemeyre Cordeiro; Patrícia V. Mendonça; Armenio Serra; Jorge Coelho; Faneca H. "Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel". Biomacromolecules (2023): http://dx.doi.org/10.1021/acs.biomac.2c01329. 10.1021/acs.biomac.2c01329 Ribeiro, Jessica P.M.; Mendonça, Patrícia V.; Santo, Daniela; De Bon, Francesco; Faneca, Henrique; Guliashvili, Tamaz; Coelho, Jorge F.J.; Serra, Arménio C.. "Expanding the use of affordable CuSO4·5H2O in ATRP techniques in homogeneous media". Polymer 241 (2022): 124526. http://dx.doi.org/10.1016/j.polymer.2022.124526. 10.1016/j.polymer.2022.124526 Costa, Diana; Santo, Daniela; Domingues, Cátia; Veiga, Francisco; Faneca, Henrique; Figueiras, Ana. "Recent advances in peptide-targeted micelleplexes: Current developments and future perspectives". International Journal of Pharmaceutics 597 (2021): 120362. http://dx.doi.org/10.1016/j.ijpharm.2021.120362. 10.1016/j.ijpharm.2021.120362 Santo, Daniela; Mendonça, Patrícia V.; Lima, Mafalda S.; Cordeiro, Rosemeyre A.; Cabanas, Luis; Serra, Arménio; Coelho, Jorge F.J.; Faneca, Henrique. "Poly(ethylene glycol)-block-poly(2-aminoethyl methacrylate hydrochloride)-Based Polyplexes as Serum-Tolerant Nanosystems for Enhanced Gene Delivery". Molecular Pharmaceutics 16 5 (2019): 2129-2141. http://dx.doi.org/10.1021/acs.molpharmaceut.9b00101. Published • 10.1021/acs.molpharmaceut.9b00101 Santo, Daniela; Cordeiro, Rosemeyre A.; Sousa, Ana; Serra, Arménio; Coelho, Jorge F.J.; Faneca, Henrique. "Combination of Poly[(2-dimethylamino)ethyl methacrylate] and Poly(ß-amino ester) Results in a Strong and Synergistic Transfection Activity". Biomacromolecules 18 10 (2017): 3331-3342. http://dx.doi.org/10.1021/acs.biomac.7b00983. 10.1021/acs.biomac.7b00983 Cordeiro, Rosemeyre A.; Santo, Daniela; Farinha, Dina; Serra, Arménio; Faneca, Henrique; Coelho, Jorge F.J.. "High transfection efficiency promoted by tailor-made cationic tri-block copolymer-based nanoparticles". Acta Biomaterialia 47 (2017): 113-123. http://dx.doi.org/10.1016/j.actbio.2016.10.015. 10.1016/j.actbio.2016.10.015
Thesis / Dissertation	Santo, Daniela. "Avaliação da capacidade de transporte e entrega de material genético associada a diferentes nanossistemas de base polimérica". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2016. http://hdl.handle.net/10316/41482.

Award

2019	Best poster award - 31st Nano Congress for Future Advancements, 2019.

Other distinction

2011	Quadro de Mérito Académico Ministério da Educação, Portugal