Ricardo Marques (8817-606C-399F)

Curriculum Vitae

Ricardo Marques

Ricardo Marques completed his PhD in Biomedicine (2016) at the University of Beira Interior, Portugal, with the publication of groundbreaking data on the cytoprotective role of the regucalcin gene in the development of breast cancer. In the same year, he took up a post-doctoral position under the supervision of Dr. Leonie Young at the Royal University of Surgeons in Ireland (RCSI), a renowned expert in endocrine resistance in breast cancer, researching the identification of new biomarkers for the development of new therapeutic targets. Significantly, the ADAM22/LGI1MIM complex was first discovered as a novel drug target in brain metastases and, in collaboration with Pfizer, a drug-conjugated ADAM22 antibody was sorted and demonstrated to be effective in vitro, enabling the transition to in vivo testing. In 2017, he was a research associate in the group of Dr. Paulo Oliveira - Mitochondrial Toxicology and Experimental Therapeutics lab at the Centre for Innovative Biomedicine and Biotechnology (CIBB) of the University of Coimbra, where he worked on the metabolic remodeling of cancer cell mitochondria. Since October 2021, Ricardo is invited adjunct professor at the Polytechnic Institute of Guarda and from 2024/01 integrated research member at "BRIDGES - Biotechnology Research, Innovation and Design for Health Products". To date, he has been involved as a team member in several funded projects, published 16 research papers and 2 book chapters, obtained 274 citations with an H-index of 12, and supervised 2 MsC. His research interests currently relate to oncologic alterations at the metabolic, genetic and molecular levels, as well as drug resistance and metastasis.

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Identification

Personal identification

Full name: Ricardo Marques

Citation names

Marques, R
Marques RJF
Ricardo J Marques

Author identifiers

Ciência ID: 8817-606C-399F
ORCID iD: 0000-0002-4749-7523
Google Scholar ID: https://scholar.google.pt/citations?hl=pt-PT&user=F0hlBZUAAAAJ
Researcher Id: B-1546-2015
Scopus Author Id: 57201760563

Email addresses

rmarques@ipg.pt (Professional)
rmarkes14129@gmail.com (Personal)

Addresses

Avenida Dr. Francisco Sá Carneiro nº 50 , 6300-559, Guarda, Guarda, Portugal (Professional)

Knowledge fields

Medical and Health Sciences - Clinical Medicine - Oncology
Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Advanced (C1)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)	Beginner (A1)	Intermediate (B1)
Portuguese	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

Education

	Degree	Classification
2020/08/17 - 2020/08/28 Concluded	29th Annual Short Course on Experimental Models of Human Cancer (Outros) The Jackson Laboratory, United States
2017/02/28 - 2017/03/02 Concluded	Laboratory Animal Science & Training (Outros) Last-Ireland Ltd, Ireland
2016/02/26 Concluded	Biomedicina (Doutoramento) Major in Sem especialidade Universidade da Beira Interior, Portugal "Biological evidence of the protective role of regucalcin in beast cancer" (THESIS/DISSERTATION)	Excelente
2014/10/10 - 2014/11/28 Concluded	Molecular Oncology: Cancer biology and emergent therapies (Outros) Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal
2014/02/10 - 2014/02/14 Concluded	2nd Edition NMR from theory to practice (Outros) Universidade da Beira Interior, Portugal
2013/11/22 - 2013/11/24 Concluded	1st Hands-On Course on Fluorescence Microscopy and Image Analysis (Outros) Universidade da Beira Interior, Portugal
2010/04/06 - 2010/04/11 Concluded	An integrative approach to cell analysis: cell and tissue culture, flow cytometry and microscopy (Outros) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009/07 Concluded	Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal "Avaliação dos efeitos do sildenafil na função mitocondrial com ênfase na isquémia-reperfusão: mecanismos moleculares da acção farmacológica e toxicológica" (THESIS/DISSERTATION)	18
2007/07 Concluded	Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal "Mecanismos mitocondriais da acção farmacológica e toxicológica do sildenafil" (THESIS/DISSERTATION)	14

Affiliation

Science

	Category Host institution	Employer
2021/02 - 2021/05	Postdoc (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2020/06 - 2021/02	Auxiliary Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2017/11/01 - 2020/06/30	Postdoc (Research)	CNC.IBILI, Portugal

2016/06/01 - 2017/11/01	Postdoc (Research)	Royal College of Surgeons in Ireland, Ireland
	Royal College of Surgeons in Ireland, Ireland
2014/10/01 - 2015/03/01	Researcher (Research)	Universidade da Beira Interior, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2021/10 - Current	Invited Adjunct Teacher (Polytechnic Teacher)	Instituto Politécnico da Guarda, Portugal
	Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal

Others

	Category Host institution	Employer
2010/03/01 - 2016/02/26	Ph.D fellowship "Biological evidence of the protective role of regucalcin in breast cancer" Fundação para a Ciência e a Tecnologia (Lisbon, Portugal) Grant: SFRH/BD/66875/2009	Universidade da Beira Interior, Portugal

2007/09/01 - 2009/07/01	MSc researcher project “Mitochondrial Sildenafil effects in ischemia/reperfusion: molecular mechanisms of pharmacologic and toxicological action”, University of Coimbra	Universidade de Coimbra, Portugal

2006/10/01 - 2007/07/01	BSc research project “Pharmacologic and toxicological sildenafil action mechanisms in mitochondria”	Universidade da Beira Interior, Portugal

Projects

Grant

	Designation	Funders
2021/01/01 - 2023/12/31	Radiocomplexos Dirigidos a Organelos Celulares para Terapia Auger do Cancro PTDC/MED-QUI/1554/2020 Integration into Research Grant Fellow Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Centro de Ciências e Tecnologias Nucleares, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/11 - 2019/12	Tackling cancer stem cells: a challenge and an opportunity to advance in anti-cancer therapy POCI-01-0145-FEDER-016390	Ministério da Ciência Tecnologia Inovações e Comunicações
2010/03 - 2016/02/26	Biological evidence of the protective role of regucalcin in breast cancer SFRH/BD/66875/2009 PhD Student Fellow	Fundação para a Ciência e a Tecnologia Concluded
2014/10 - 2015/04	Hormonal and Inflammatory basis of age-related diseases CENTRO-07-ST24-FEDER-002015 Research Fellow	Programa Operacional Regional do Centro 2007-2013 QREN (Programa “Mais Centro”)
2010/03/01 - 2014/02/28	ROLE OF REGUCALCIN IN PROLIFERATION AND APOPTOSIS IN NEOPLASTIC AND NON-NEOPLASTIC HUMAN BREAST CELLS SFRH/BD/66875/2009	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2024/12/31	Radiocomplexos Dirigidos a Organelos Celulares para Terapia Auger do Cancro PTDC/MED-QUI/1554/2020 10.54499/PTDC/MED-QUI/1554/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/01/01 - 2020/12/31	Estaminalidade das células do cancro: um desafio e uma oportunidade para avançar no tratamento em Oncologia SAICTPAC/0022/2015 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal Fundação Calouste Gulbenkian, Portugal Universidade de Coimbra, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Health Sciences Research Centre UID/Multi/00709/2019 Universidade da Beira Interior, Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Health Sciences Research Centre UID/Multi/00709/2019 Universidade da Beira Interior, Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Silva, F.S.G.; Costa, C.F.; Marques, R.J.; Oliveira, P.J.; Pereira, G.C.. Pharmacological targeting of the mitochondrial permeability transition pore for cardioprotection. 2018. Vaz, C.V.; Alves, M.G.; Marques, R.; Oliveira, P.F.; Maia, C.J.; Socorro, S.. Glucose uptake and androgen responsiveness of prostate cancer cells. 2013.
Conference abstract	Marques, R. "Oxidant/antioxidant imbalance in lymphoblasts from amyotrophic lateral sclerosis patients with SOD1 mutations and unknown mutations". 2020. Marques, R; Afonso, J; Barbosa-Matos C; Michaelis M; Longatto, Adhemar; Cinatl JrJ; Sardão, Vilma; et al. "Metabolic remodelling in cisplatin-resistant bladder cancer". Paper presented in EACR-AACR-ASPIC Conference on Tumor Microenvironment, 2020. Marques, R; Vaz, Cátia (1C1D-F91F-D937); Maia CJ; Socorro, Sílvia. "Regucalcin in hormone-dependent cancers: towards a candidate tumour suppressor gene?". Paper presented in EACR24th From basic research to precision medicine, Manchester, 2016. 10.1016/S0959-8049(16)61149-8 Figueira, MI; Sara Correia; Vaz, CV; Cardoso, HJ; Gomes, IM; Ricardo J Marques; Maia, CJ; Socorro, Sílvia. "Estrogenic actions in the prostate: are the stem cell factor (SCF) and c-KIT receptor involved?". Paper presented in I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences, COVILHÃ, 2015. Published Figueira, MI; Sara Correia; Vaz, CV; Cardoso, HJ; Gomes, IM; Ricardo J Marques; Maia CJ; et al. "Estrogens downregulate the stem cell factor (SCF)/cKIT system in rat prostate: evidence of antiproliferative and apoptotic effects". Paper presented in IX ANNUAL CICS SYMPOSIUM, COVILHÃ, 2014. Published • 10.1016/j.bcp.2015.11.016 Marques, Ricardo; Vaz, Cátia (1C1D-F91F-D937); Alves, M.G.; Moreira, PI; Oliveira PF; Cavaco, J.E.; Maia CJ; et al. "Androgens regulate gene expression of glucose transporters and glycolytic enzymes in prostate cancer cells". Paper presented in 16th European Congress of Endocrinology, Wroclaw, 2014. 10.1530/endoabs.35.P571 Marques, R; Vaz, CV; Maia CJ; Gama, A.; Alves, G.; Schmitt, F.; Santos, CR; Socorro, Sílvia. "Transgenic rats overexpressing Regucalcin display lower-susceptibility to develop DMBA-induced mammary gland tumors". Paper presented in 38th Federation of European Biochemical Societies Congress – Mechanisms in Biology, St. Petersburg, 2013. 10.1111/febs.12340 Marques, R; Vaz, CV; Alves MG; Oliveira PF; Maia CJ; Socorro, Sílvia; Vaz, Cátia. "Glucose Metabolism and Androgen Responsiveness of Prostate Cancer Cells". Paper presented in 38th Federation of European Biochemical Societies Congress – Mechanisms in Biology, St. Petersburg, 2013. https://doi.org/10.1111/febs.12340 Marques, Ricardo; Vaz, CV; Peres CG; Gomes, I.; Santos, CR; Maia CJ; Socorro, Sílvia; Peres CG,; Gomes I.. "Effect of Androgens on the Expression of Ca2+-binding Protein, Regucalcin, and Ca2+-channels in MCF-7 Cells". Paper presented in 22nd Congress of European Association for Cancer Research - from Basic Research to Personalised Cancer Treatment, Barcelona, 2012. 10.1016/S0959-8049(12)70876-6 Marques, R; Vaz, CV; Maia CJ; Alves MG; Cavaco JE; Oliveira PF; Socorro, Sílvia; Alves MG,; Cavaco JE,. "Expression of Apoptosis and Cell-cycle Regulators in Rat Prostate Overexpressing Regucalcin". Paper presented in 2nd Congress of European Association for Cancer Research - from Basic Research to Personalised Cancer Treatment, Barcelona, 2012. 10.1016/S0959-8049(12)70871-7
Conference paper	Ricardo J Marques; Vaz, CV; Peres, Carina; Gomes, I.; SANTOS, Cecilia R A; Maia, Cláudio J. B.; Socorro, Sílvia. "177 Effect of Androgens on the Expression of Ca2+-binding Protein, Regucalcin, and Ca2+-channels in MCF-7 Cells". 2012. 10.1016/s0959-8049(12)70876-6
Conference poster	Marques, R. "The anti-oxidant activity of P-cadherin promotes metastasis and doxorubicin resistance in breast cancer". Paper presented in EACR-AACR-ASPIC Conference on Tumor Microenvironment, 2020. Marques, R; Serafim, Teresa; Deus CM; Silva, F.S.G.; Sardão, Vilma; Dias, Sérgio; Oliveira, Paulo; Cláudia M. Deus. "Glucose dependence and metabolic reprogramming of commercial breast cancer cells.". Paper presented in EACR-AACR-ASPIC Conference on Tumor Microenvironment, 2020. Marques, R; Carvalho, M; Borges D; Oliveira, Paulo; Silva FSG. "Alterations in mitochondrial biogenesis and regulation of morphology in lymphoblasts from amyotrophic lateral sclerosis patients.". Paper presented in 2nd FEBS 2019 Advanced Course on. Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019. Marques, R; Borges D; Carvalho, M; Oliveira, Paulo; Silva FSG. "Understanding the influence of SOD1 mutation on mitochondrial mechanisms of autophagy and apoptosis in lymphoblasts from amyotrophic lateral sclerosis patients". Paper presented in 2nd FEBS 2019 Advanced Course on. Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019. Marques, R; Sousa, Bárbara; Sardão, Vilma; Schmitt, F.; Oliveira, Paulo; Paredes, Joana. "P-cadherin induces anoikis resistance in breast cancer stem cells by rewiring the metabolic flux and activating of antioxidant systems". Paper presented in 2nd FEBS 2019 Advanced Course on. Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019. Marques, R; Deus C; Silva, F.S.G.; Sardão, Vilma; Oliveira, Paulo; Serafim, Teresa. "Metabolic reprogramming forwards oxidative phosphorylation in breast cancer cells as potential drug targets". Paper presented in 2nd FEBS 2019 Advanced Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019. Marques, R; Oliveira GL; Oliveira, Paulo; Silva MR; Silva RM; Sousa, S.; Sardão, Vilma; Paredes J; Oliveira, G.. "ANT2 Silencing Promotes a Metabolic Shift in P19 Embryonal Carcinoma Stem Cells". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019. https://doi.org/10.1111/eci.13109 Marques, R; Afonso J,; Barbosa-Matos C; Michaelis M; Longatto A; Santos L,; Cinatl JrJ; Sardão, Vilma; Baltazar F. "Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogramming". Paper presented in Porto Cancer Meeting, 2019. Marques, R; Sousa, B.; Pereira, J.; Nobre AR; Carneiro P,; Sardão, Vilma; Schmitt, F.; Oliveira, Paulo; Paredes, Joana. "P- Cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative". Paper presented in 3rd ASPIC International congress, 2018. Marques, R; Doherty, B.; Charmsaz S; Hill A; Young L. "Deciphering Adam22 mechanisms in endocrine resistant breast cancer". Paper presented in 7th RPPA global workshop, 2017. 10.1158/1538-7445.am2018-3744 Marques, R; Vaz, CV; Maia CJ; Socorro, Sílvia. "Role of the androgen-target gene regucalcin in breast cancer and prostate physiology". Paper presented in 2nd ASPIC International Congress, 2016. Marques, R; Vaz, CV; Cavaco JE,; Maia CJ; Socorro, Sílvia. "Regucalcin, a calcium (Ca2+)-binding protein with a protective role in prostate age-related diseases?". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014. Marques, R; Vaz, CV; Gomes, IM; Cairrão ME; Verde JI; Maia CJ; Socorro, Sílvia. "Abstract 1989: The effect of resveratrol combined with DFMO or DenSpm on MCF-7 breast cancer cells and MCF-10a non-cancerous cells". Paper presented in . XVIII Congress of the Portuguese Biochemical Society, 2014. 10.1158/1538-7445.am2012-1989 Marques, R; Vaz, CV; Gomes IM; Gomes, IM; Alves MG; Cavaco JE; Oliveira PF; Socorro, Sílvia. "Regucalcin, a new androgen target gene involved in the regulation of prostate cell growth". Paper presented in 1st ASPIC International Congress, 2014. Marques, R; Figueira MI; Correia, S.; Vaz, CV; Cardoso HJ,; Gomes IM; Maia CJ; Socorro, Sílvia. "The estrogenic regulation of stem cell factor (SCF) and c-KIT in rat prostate supports the protective role of estrogens in prostate cancer". Paper presented in 1st ASPIC International Congress, 2014. Marques, R; Vaz, CV; Maia CJ; Gomes M,; Gama A,; Alves G,; Santos CR,; Schmitt F,; Socorro, Sílvia. "Regucalcin, as a protective molecule in breast cancer: clinicohistopathological and in vivo evidences". Paper presented in 1st ASPIC International Congress, 2014. Marques, R; Socorro, Sílvia; Santos, CR. "Transgenic rats overexpressing regucalcin display lower susceptibility to develop DMBA-induced mammary gland tumors". Paper presented in 38th Federation of European Biochemical Societies Congress – Mechanisms in Biology, 2013. Marques, R; Vaz, CV; Alves MG,; Moreira PI; Oliveira PF,; Maia CJ; Socorro, Sílvia. "Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile". Paper presented in A One Day Symposium of European Association for Cancer Research, 2012. 10.1016/j.biocel.2012.08.013 Marques, R; Capote TC; Rocha-Pereira P; Custódio, JBA. "Toxicological effects of carbamazepine and homocysteine in liver and heart mitochondria". Paper presented in Mitochondria: Between Life and Death - International Courses on Toxicology, 2009. Marques, R; Custódio J,; Vicente J,; Santos M,; Moreno A,; Fernandes, M.,. "Sildenafil Citrate does not change rat heart mitochondria functions and prevents oxidative stress". Paper presented in Metabolic Toxicology: from pathway to organism- International Courses on Toxicology, 2009.
Journal article	Marília I. Figueira; Ricardo Marques; Henrique J. Cardoso; Lara R. S. Fonseca; Ana P. Duarte; Samuel Silvestre; Sílvia Socorro. "Effect of Diosgenin in Suppressing Viability and Promoting Apoptosis of Human Prostate Cancer Cells: An Interplay with the G Protein-Coupled Oestrogen Receptor?". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms252212006. 10.3390/ijms252212006 Teresa Cunha-Oliveira; Daniela Franco Silva; Luis Segura; Inês Baldeiras; Ricardo Marques; Tatiana Rosenstock; Paulo J. Oliveira; Filomena S. G. Silva. "Redox profiles of amyotrophic lateral sclerosis lymphoblasts with or without known SOD1 mutations". European Journal of Clinical Investigation 52 9 (2022): https://doi.org/10.1111/eci.13798. 10.1111/eci.13798 Marques, R. "Cancer cell metabolism: rewiring the mitochondrial hub.". Biochimica et biophysica acta. Molecular basis of disease (2020): https://doi.org/10.1016/j.bbadis.2020.166016. 10.1016/j.bbadis.2020.166016 Marques, R. "ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.". BMC medicine (2020): https://europepmc.org/articles/PMC7677775. 10.1186/s12916-020-01806-4 Sousa B; Pereira J; Marques R; Grilo LF; Pereira SP; Sardão VA; Schmitt F; Oliveira PJ; Paredes J. "P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress.". Biochimica et biophysica acta. Molecular basis of disease (2020): http://europepmc.org/abstract/med/32920119. 10.1016/j.bbadis.2020.165964 Vaz, C.V.; Marques, R.; Cardoso, H.J.; Maia, C.J.; Socorro, S.. "Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation". Transgenic Research 25 2 (2016): 139-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946811164&partnerID=MN8TOARS. 10.1007/s11248-015-9918-0 Vaz, C.V.; Correia, S.; Cardoso, H.J.; Figueira, M.I.; Marques, R.; Maia, C.J.; Socorro, S.. "The emerging role of regucalcin as a tumor suppressor: Facts and views". Current Molecular Medicine 16 7 (2016): 607-619. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989246357&partnerID=MN8TOARS. 10.2174/1566524016666160714124550 Vaz, C.V.; Marques, R.; Alves, M.G.; Oliveira, P.F.; Cavaco, J.E.; Maia, C.J.; Socorro, S.. "Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes". Journal of Cancer Research and Clinical Oncology 142 1 (2016): 5-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953637162&partnerID=MN8TOARS. 10.1007/s00432-015-1992-4 Marques, R.; Vaz, C.V.; Maia, C.J.; Gomes, M.; Gama, A.; Alves, G.; Santos, C.R.; Schmitt, F.; Socorro, S.. "Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis". Experimental Cell Research 330 2 (2015): 325-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919789386&partnerID=MN8TOARS. 10.1016/j.yexcr.2014.08.007 Cardoso, H.J.; Vaz, C.V.; Correia, S.; Figueira, M.I.; Marques, R.; Maia, C.J.; Socorro, S.; et al. "Paradoxical and contradictory effects of imatinib in two cell line models of hormone-refractory prostate cancer". Prostate 75 9 (2015): 923-935. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929996402&partnerID=MN8TOARS. 10.1002/pros.22976 Vaz, C.V.; Marques, R.; Maia, C.J.; Socorro, S.. "Aging-associated changes in oxidative stress, cell proliferation, and apoptosis are prevented in the prostate of transgenic rats overexpressing regucalcin". Translational Research 166 6 (2015): 693-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960503071&partnerID=MN8TOARS. 10.1016/j.trsl.2015.08.009 Marques, R.; Peres, C.G.; Vaz, C.V.; Gomes, I.M.; Figueira, M.I.; Cairrão, E.; Verde, I.; Maia, C.J.; Socorro, S.. "5a-Dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth". Medical Oncology 32 9 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84938787084&partnerID=MN8TOARS. 10.1007/s12032-015-0676-x Vaz, C.V.; Maia, C.J.; Marques, R.; Gomes, I.M.; Correia, S.; Alves, M.G.; Cavaco, J.E.; Oliveira, P.F.; Socorro, S.. "Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways". Prostate 74 12 (2014): 1189-1198. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904658283&partnerID=MN8TOARS. 10.1002/pros.22835 Marques, R.; Maia, C.J.; Vaz, C.; Correia, S.; Socorro, S.. "The diverse roles of calcium-binding protein regucalcin in cell biology: From tissue expression and signalling to disease". Cellular and Molecular Life Sciences 71 1 (2014): 93-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891882606&partnerID=MN8TOARS. 10.1007/s00018-013-1323-3 Vaz, C.V.; Alves, M.G.; Marques, R.; Moreira, P.I.; Oliveira, P.F.; Maia, C.J.; Socorro, S.. "Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile". International Journal of Biochemistry and Cell Biology 44 11 (2012): 2077-2084. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865554409&partnerID=MN8TOARS. 10.1016/j.biocel.2012.08.013 Fernandes, M.A.S.; Marques, R.J.F.; Vicente, J.A.F.; Santos, M.S.; Monteiro, P.; Moreno, A.J.M.; Custódio, J.B.A.. "Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H2O2 generation by rat heart mitochondria". Molecular and Cellular Biochemistry 309 1-2 (2008): 77-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-38649099116&partnerID=MN8TOARS. 10.1007/s11010-007-9645-9
Thesis / Dissertation	Marques, R. "Biological evidence of the protective role of regucalcin in breast cance". PhD, Universidade da Beira Interior, 2016. http://hdl.handle.net/10400.6/4214. Marques, R. "Avaliação dos efeitos do sildenafil na função mitochondrial com ênfase na isquémia-reperfusão: mecanismos moleculares da acção farmacológica e toxicológica". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009. Marques, R. "Mecanismos mitochondriais da acção farmacológica e toxicológica do silfenafil". Degree, Universidade da Beira Interior, 2007.

Other

Other output

Adenine nucleotide translocase 2 silencing promotes metabolic adaptations and anoikis in P19 embryonal carcinoma stem cells. 2024. Oliveira, G.L.; Mota, S.I.; Oliveira, P.J.; Marques, R.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85199364178&partnerID=MN8TOARS.
10.1101/2024.06.07.597817
Oxidative stress profiles of lymphoblasts from Amyotrophic Lateral Sclerosis patients with or without known SOD1 mutations. 2022. Cunha-Oliveira, T.; Franco Silva, D.; Segura, L.; Baldeiras, I.; Marques, R.; Rosenstock, T.; Oliveira, P.J.; Silva, F.S.G.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85129417547&partnerID=MN8TOARS.
10.1101/2022.03.03.482309
Regucalcin as a new tumor suppressor gene?. 2016. Vaz, CV; Sara Correia; Cardoso, HJ; Figueira, MI; Ricardo J Marques; Maia CJ; Socorro, Sílvia. http://www.aspic.pt/pt-pt/node/4657.
Regucalcin controls prostate cell proliferation and glycolytic metabolism. 2016. Vaz, CV; Ricardo J Marques; Cardoso, HJ; Maia CJ; Socorro, Sílvia. https://atlasofscience.org/regucalcin-controls-prostate-cell-proliferation-and-glycolytic-metabolism/.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2018/10	P- Cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative	ISCAM Metabolic adaptations and targets in cancer (Bratislava, Slovakia)
2015/11	Estrogenic actions in the prostate: are the stem cell factor (SCF) and c-KIT receptor involved?	Ist Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences CICS-UBI (COVILHA, Portugal)
2015/11	Androgens as calcium-modulators in human breast cancer cells: effects of 5a-dihydrotestosterone in MCF-7 cells	Ist Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences CICS-UBI (COVILHA, Portugal)
2015/06	Androgens as key regulators of glycolytic metabolism: a relationship with development of prostate cancer?	X Annual CICS Symposium CICS-UBI – Health Sciences Research Centre, University of Beira Interior (COVILHA, Portugal)
2014/06	Estrogens down-regulate the stem cell factor (SCF)/c-KIT system in rat prostate: evidence of antiproliferative and apoptotic effects	IX Annual CICS Symposium CICS-UBI – Health Sciences Research Centre, University of Beira Interior (COVILHA, Portugal)
2014/06	Paradoxical and contradictory effects of imatinib in two cell line models of prostate cancer	IX Annual CICS Symposium CICS-UBI – Health Sciences Research Centre, University of Beira Interior (COVILHA, Portugal)
2014/06	Exploiting the role of regucalcin in prostate pathophysiology	IX Annual CICS Symposium CICS-UBI – Health Sciences Research Centre (COVILHA, Portugal)
2014/06	Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis	IX Annual CICS Symposium CICS-UBI – Health Sciences Research Centre, University of Beira Interior (COVILHA, Portugal)
2012	Androgens in breast cancer cells physiology: a connection with calcium homeostasis?	VII ANNUAL CICS Symposium CICS-UBI – Health Sciences Research Centre, University of Beira Interior (COVILHA, Portugal)
2009/05	Sildenafil Citrate effects in cardiac reperfusion injury mitochondria	V International Courses on Toxicology - "Mitochondria: between life and death" (Coimbra, Portugal)
2008/12/05	Does sildenafil citrate protect mitochondria against heart ischemic/reperfusion?	Annual Reunion of Portuguese Pharmacological Society, XXVI Annual Reunion of Clinic Pharmacology and VIII Reunion of Toxicology Portuguese Pharmacological Society (Lisboa, Portugal)
2008/12	Effect of carbamazepine, homocysteine, homocysteine tiolactone in the mitochondrial permeability transition pore opening	XXXIX Annual Reunion of Portuguese Pharmacological Society, XXVI Annual Reunion of Clinic Pharmacology and VIII Reunion of Toxicology Portuguese Pharmacological Society (Lisboa, Portugal)
2007/12	Sildenafil Citrate concentrations not affecting oxidative phosphorylation protect rat heart mitochondria from oxidative stress. XXXVIII Annual Reunion of Portuguese Pharmacological Society, XXIV Annual Reunion Clinic Pharmacology and VII Reunion of Toxicology, 5-7th December 2007, Coimbra, Portugal	XXXVIII Annual Reunion of Reunion of Portuguese Pharmacological Society , XXIV Annual Reunion Clinic Pharmacology and VII Reunion of Toxicology Portuguese Pharmacological Society (Coimbra, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2018/09 - 2019/09	P-cadherin role on the mitochondrial biology of breast cancer cells Supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09 - 2019/09	Role of the Adenine Nucleotide Translocator 2 in P19 Embryonal Carcinoma Stem Cells Mitochondrial Supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019/09/01 - 2019/09/06	2nd FEBS 2019 Advanced Lecture Course on Oncometabolism: from conceptual Knowdledge to clinical applications (2019/09/01 - 2019/09/06) Congress (Co-organisor)	Federation of European Biochemical Societies, United Kingdom

Event participation

	Activity description Type of event	Event name Institution / Organization
2021/01/20 - 2021/01/20	In vitro functional assays in cancer research Workshop	Fundamentals of Cellular and Molecular Metabolism: Relevance for Health and Disease Universidade de Coimbra, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/12/15	Jury in masters thesis "Análise da presença de anticorpos específicos para a proteína Nucleocápside em ruminantes de explorações do Nordeste Transmontano" (Thesis) Main arguer	Dara Gothe Lima Almeida (Master) Instituto Politécnico de Bragança, Portugal
2015/06/17	Diagnóstico do cancro da mama por micro-ondas (Thesis) Main arguer	David Carrageta (Other) Universidade da Beira Interior, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2023 - Current	Human and molecular genetics
2021 - Current	Celular biology and histology	(Licenciatura)	Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal
2021 - Current	Biochemsitry
2021 - Current	Genomic, metabolomic and proteomic
2021 - Current	Biophysics
2021 - Current	Genetics and clinical aplications
2019/04/01 - 2019/06/17	Aspetos gerais da produção de energia na célula. Glicólise, Ciclo de krebs e fosforilação oxidativa	(Ensino secundário)	Instituto de Educação e Cidadania, Portugal
2019/03/11 - 2019/03/15	3D cancer stem cell models and methods to address metabolism	(Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Coimbra, Portugal

Mentoring / Tutoring

	Topic	Student name
2021/01 - 2021/02		Rafael Silveira
2020/08 - 2020/10		Ana Pedrosa
2017/12/01 - 2019/12/31	Caracterização fisiológica mitocondrial em linhas celulares de cancro da mama	Óscar Emanuel de Melo Rodrigues
2018/06/04 - 2018/07/07		Margarida Ribeiro da Silva
2018/05/13 - 2018/06/08		Gabriela Lopes Oliveira
2018/01/29 - 2018/02/23		Gabriela Lopes Oliveira
2017/12/01 - 2017/12/31	Caracterização da fisiológica mitocondrial em linhas celulares de cancro da mama	Sara Inês Furtado Canário
2017/04 - 2017/06	Mechanism of Action in Metastatic Breast Cancer	Karishma Roopchand

Distinctions

Award

2015	Best Oral Presentation
2013	Travel fellowship to attend to 13th Young Scientists Forum and 38th FEBS Congress 2013 in St Petersburg, Russia

Other distinction

2009	PhD felowship Grant: SFRH/BD/66875/2009 Fundação para a Ciência e a Tecnologia, Portugal