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Clara Quintas (PharmD, PhD) is an Assistant Professor at the University of Porto, Faculty of Pharmacy (FFUP), teaching since 2006 on the Integrated Master's Degree in Pharmaceutical Sciences and since 2014 on the Doctoral Programme in Experimental and Clinical Pharmacology and Toxicology. At FFUP, she has been a member of the Pedagogical Council since 2020 and of the Quality and Continuous Improvement Office since 2023. Clara Quintas is a researcher at MecPharm research lab at UCIBIO/i4HB. Co-supervises 1 doctoral thesis and 1 master thesis and supervised several national and Erasmus Integrated Master's and Bachelor's degree students. Works in the area(s) of Medical and Health Sciences with emphasis on purinergic signalling in brain inflammation. More recently, a broad and varied scientific trajectory reflects her contribution to an interdisciplinary approach in different fields such as cancer, peripheral inflammatory diseases, and dermatology. Published 22 full-lenght articles in peer-reviewed journals. Has received 5 awards and/or honors. Her h-index is 9, with her work accumulating 305 citations across 266 documents. Throughout her career, she has collaborated with 62 co-authors. Clara Quintas has been involved in six national and international research projects.
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Identification

Personal identification

Full name
Maria Clara Ferreira de Oliveira Quintas

Citation names

  • Quintas, Clara
  • Quintas, C

Author identifiers

Ciência ID
8811-FE8F-3A39
ORCID iD
0000-0002-2087-1773
Researcher Id
D-4771-2013
Scopus Author Id
8684906900

Email addresses

  • claraquintas@ff.up.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2011
Concluded
 PhD in Pharmaceutical Sciences - Pharmacology and Pharmacoterapy Specialty (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Modulation of astrogliosis by P2Y receptors through a dialogue between microglia and astrocytes" (THESIS/DISSERTATION)
 Approved with distinction by unanimity
2004
Concluded
 Pharmaceutical Sciences (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
""n/a"" (THESIS/DISSERTATION)
 16 out of 20
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2012/06/06 - Current Assistant Professor (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
2006/02/23 - 2012/06/05 Invited Assistant (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2023/07/11 - 2027/07/10 MILESTONE - Monitoring inflammatory bowel disease and response to biologic therapy through ACE2/ACE balance
NA
Researcher
Universidade do Porto Faculdade de Farmácia, Portugal
 Grupo de Estudo da Doença Inflamatória Intestinal (GEDII)
Ongoing
2006 - 2009 CARACTERIZAÇÃO DO PAPEL DO ATP NOS EFEITOS NEUROPROTECTORES DOS ASTRÓCITOS
SFRH/BD/23907/2005
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022 The pediatric roots of amplified pain: from contextual influences to risk stratification
PTDC/SAU-EPI/29087/2017
Universidade do Porto Instituto de Saúde Pública, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2015 - 2016 Proteostasia da huntingtina e mitocôndria: alvos para prevenir a disfunção neuronal na doença de Huntington
PTDC/NEU-NMC/0412/2014
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2014 ASTROCYTE-MICROGLIA CROSSTALK IN ASTROGLIOSIS: MODULATION BY P2 RECEPTORS
PTDC/SAU-TOX/115597/2009
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Quintas, C; Silva, R; Gonçalves, J; Queiroz, G. "Influence of Microglia PPARgamma Activation in the Control of Purinergic-Mediated Astroglial Proliferation". Paper presented in 14Th European Meeting on Glial Cells in Health and Disease (Glia), 2019.
  2. Pinho, D; Quintas, C; Sardo, Filipa; Queiroz, Glória. "Glial P2Y receptors contribute to the regulation of noradrenergic transmission in the rat brain cortex.". Paper presented in 22nd IUBMB Congress/37th FEBS Congress, 2012.
  3. Queiroz, Glória; Quintas, Clara; Magalhães, João; Gonçalves, Jorge. "Microglia P2Y6 receptors mediate an inhibition of astroglia proliferation in cultures of rat brain cortex. Purinergic Signal". Paper presented in Purines 2010 - Adenine Nucleosides and Nucleotides in Biomedicine, Tarragona-Barcelona, 2010.
    Published
  4. Quintas, Clara; Magalhães, João; Gonçalves, Jorge; Queiroz, Glória. Corresponding author: Quintas, Clara. "P2Y6 receptors inhibit astroglia proliferation in cultures with activated microglia. Front Neurosci doi: 10.3389/conf.neuro.01.2009.11.055". Paper presented in 11ª Reunião Científica Nacional da Sociedade Portuguesa de Neurociências, Braga, 2009.
    Published
  5. Quintas, Clara; Magalhães, João; Gonçalves, Jorge; Queiroz, Glória. "Inhibition of astroglia proliferation by nucleotides: contribution of P1 receptors. Purinergic Signal". Paper presented in Third Joint Italian-German Purine Club Meeting, Camerino, 2009.
    Published
  6. Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "P2Y receptor-subtypes in the modulation of noradrenaline release in rat brain cortex. Purinergic Signal". Paper presented in Purines 2008, Copenhagen, 2008.
    Published
  7. Quintas, Clara; Goncalves, Jorge ; Queiroz, Glória. "P2 receptor-subtypes in the modulation of reactive gliosis. Purinergic Signal". Paper presented in Purines 2008, Copenhagen, 2008.
    Published
  8. Queiroz, Glória; Quintas, Clara; Pestana, Diogo; Fraga, Sónia; Gonçalves, Jorge. "Influence of microglia on nucleotide-induced astroglia proliferation. Purinergic Signal". Paper presented in Purines 2008, Copenhagen, 2008.
    Published
  9. Talaia, Carlos; Queiroz, Glória; Quintas, Clara; Morato, M; Gonçalves, Jorge. "Interaction between prejunctional facilitatory receptors and nitric oxid with a2-adrenoceptors on the modulation of noradrenaline release in rat mesenteric artery. Sinapse". Paper presented in 9ª Reunião Científica Nacional da Sociedade Portuguesa de Neurociências., Luso, 2005.
    Published
  10. Queiroz, Glória; Quintas, Clara; Gonçalves, Jorge. "Evidence for involvement of protein kinases A and C on the adenosine A2B receptor-modulation of noradrenaline release in the prostatic portion of the rat vas deferens. Auton Autacoid Pharmacol". Paper presented in 11th Meeting on Adrenergic Mechanisms., Porto, 2003.
    Published
Conference poster
  1. Quintas, Clara. "Synthesis of chalcone-kojic acid hybrids with potential skin health promoting effects". Paper presented in XXVIII ENCONTRO GALEGO PORTUGUÉS DE QUÍMICA, 2025.
  2. Quintas, C; Fernandez-Llimos, Fernando ; Jorge Gonçalves; Glória Queiroz. "The inflammatory ATP-enriched environment drives microglia towards an m1-like phenotype that inhibits astroglial proliferation". Paper presented in EPHAR 2024 - 9th European Congress of Pharmacology, 2024.
  3. Quintas, C; Silva Rui; Gonçalves Jorge; Glória Queiroz. "Activation of microglia P2X4 and P2X7 receptors impairs purinergic-induced astroglial proliferation". Paper presented in EPHAR 2024 - 9th European Congress of Pharmacology, 2024.
  4. Ferreira-Duarte, Mariana; Lilian Caroline Gonçalves Oliveira; Dulce Elena Casarini; Marisa Esteves-Monteiro; Quintas, Clara; Teresa Sousa; Margarida Duarte-Araújo; Fernando Magro; Manuela Morato. "Fecal ACE and ACE2 activities in patients with Inflammatory Bowel Disease on biological treatment". Paper presented in Gordon Research Conference – Interplay Between the RAAS and Other Hormonal Systems| February 2024, Barga, Lucca, Italy, 2024.
  5. Silva, Dany; Quintas, Clara; Gonçalves, Jorge; Fresco, Paula. "ß-Adrenergic stimulation may promote a pre-malignant phenotype in non-tumorigenic MCF-10A breast epithelial cells". Paper presented in 13th EMBO Young Scientists’ Forum, 2023.
  6. Ferreira-Duarte, Mariana; Lilian Caroline Gonçalves Oliveira; Quintas, Clara; Esteves-Monteiro, Marisa; Margarida Duarte-Araújo; Teresa Sousa; Dulce Elena Casarini; Manuela Morato. "ACE and ACE2 catalytic activity throughout the gastrointestinal tract". Paper presented in Angiotensin Gordon Research Conference - The RAAS: Molecular Networking to Multi-System Pathophysiology, 2022.
  7. Silva, Dany; Amaro, Filipa; Reguengo, Henrique; Oliveira, José C; Quintas, Clara; Vale, Nuno; Gonçalves, Jorge; Fresco, Paula. "Catecholamines produced by breast epithelial cells exert tonic effects relevant for breast cancer progression". Paper presented in 27th Porto Cancer Meeting 2021, 2021.
  8. Trigo, Catarina; Gonçalves, Jorge; Quintas, Clara; Fresco, Paula. "Insights of nitric oxide mechanisms in carcinogenesis". Paper presented in 13TH Meeting of Young Researchers of University of Porto, 2020.
  9. Quintas, C; Silva, R; Gonçalves, J; Queiroz, G. "Influence of Microglia PPARgamma Activation in the Control of Purinergic-Mediated Astroglial Proliferation". Paper presented in 14Th European Meeting on Glial Cells in Health and Disease (Glia), 2019.
  10. Quintas, Clara; Silva, Rui; Gonçalves, Jorge; Queiroz, Glória. "Influence of Microglia PPARgamma Activation In The Control of Purinergic-Mediated Astroglial Proliferation". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  11. Quintas, Clara; Vale, Nuno; Gonçalves, Jorge; Queiroz, Glória. "Microglia P2Y13 receptors prevent astrocyte proliferation mediated by P2Y1 receptors.". Paper presented in III Symposium of the Portuguese Glial Network, 2018.
  12. Quintas, Clara; Silva, Rui; Gonçalves, Jorge; Queiroz, Glória. "Unravelling the mechanisms behind microglia control of purinergic-mediated astroglial proliferation". Paper presented in III Symposium of the Portuguese Glial Network, 2018.
  13. Quintas, Clara; Goncalves, Jorge; Queiroz, Glória. "Microglia P2Y13 receptors modulate astrocyte proliferation mediated by P2Y1/12 receptors". Paper presented in XV Meeting Sociedade Portuguesa de Neurociências, 2017.
  14. Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "Astroglial proliferation induced by adenosine is mediated by A2A/2B receptors, coupled to the PKA-ERK pathway and is under control of microglia". Paper presented in XV Meeting Sociedade Portuguesa de Neurociências, 2017.
  15. Reis, Sara; Pinho Brígida R; Quintas, Clara; Oliveira, Jorge MA. "Proteostasis of full-length human huntingtin in an inducible cellular model of Huntington's disease". Paper presented in XIX National Congress of Biochemistry, 2016.
  16. Pinho, Brígida R; Reis, Sara; Quintas, Clara; Oliveira, Jorge MA. "Effects of selective HDAC inhibitors in the zebrafish MPP+ Parkinson model". Paper presented in VI Meeting on the "Molecular Mechanisms of Neurodegeneration", 2015.
  17. Pinho, Brígida R; Leitão-Rocha, Ana; Reis, Sara; Quintas, Clara; Valentão, Patrícia; Andrade, Paula B; Santos, Miguel M ; Oliveira, Jorge MA. "Metabolic and locomotor deficits in a zebrafish Parkinson model: effect of selective HDAC1 and HDAC6 inhibitors". Paper presented in XVIII congress of the Portuguese Biochemical Society, 2014.
  18. Pinho, Diana; Quintas, Clara; Sardo, Filipa; Queiroz, Glória. "Glial P2Y receptors contribute to the regulation of noradrenergic transmission in the rat brain cortex". Paper presented in 37th FEBS Congress, 2012.
  19. Pinho, Diana; Quintas, Clara; Magalhães, João; Gonçalves, Jorge; Queiroz, Glória. "P2Y6 receptors expressed by activated microglia inhibit astroglial proliferation by inducing nitric oxide mediated apoptosis". Paper presented in 5th Meeting of Young Researchers of University of Porto, 2012.
  20. Silva, Diva; Pinho, Diana; Sardo, Filipa; Quintas, Clara; Queiroz, Glória. "In the rat brain cortex NMDA receptor-evoked noradrenaline release is inhibited by adenosine A2A receptors: mechanisms involved". Paper presented in 5th Meeting of Young Researchers of University of Porto, 2012.
  21. Pinho, Diana; Belo, Renata; Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "Noradrenergic transmission in the brain cortex is modulated by astroglial purinergic receptors". Paper presented in 4th Meeting of Young Researchers of University of Porto, 2011.
  22. Belo, Renata; Pinho, Diana; Pelikánová, Tereza; Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "Purinergic modulation of NMDA-evoked release of noradrenaline from rat brain cortex". Paper presented in 4th Meeting of Young Researchers of University of Porto, 2011.
  23. Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "Activation of P2Y receptors on astrocytes and microglia oppositely modulate astroglial proliferation". Paper presented in XVII Congresso Nacional de Bioquímica, 2010.
  24. Queiroz, Glória; Quintas, Clara; Magalhães, João; Gonçalves, Jorge. "Microglia P2Y6 receptors mediate an inhibition of astroglia proliferation in cultures of rat brain cortex". Paper presented in Purines 2010 - Adenine Nucleosides and Nucleotides in Biomedicine, 2010.
  25. Quintas, Clara; Magalhães, João; Gonçalves, Jorge; Queiroz, Glória. "Inhibition of astroglia proliferation by nucleotides: contribution of P1 receptors". Paper presented in Third Joint Italian-German Purine Club Meeting, 2009.
  26. Quintas, Clara; Magalhães, João; Gonçalves, Jorge; Queiroz, Glória. "P2Y6 receptors inhibit astroglia proliferation in cultures with activated microglia". Paper presented in 11ª Reunião Científica Nacional da Sociedade Portuguesa de Neurociências, 2009.
    10.3389/conf.neuro.01.2009.11.055
  27. Magalhães, João; Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "Effects of ATP and UTP on astroglial proliferation: influence of activated microglia". Paper presented in 2nd Meeting of Young Researchers of University of Porto, 2009.
  28. Queiroz, Glória; Quintas, Clara; Pestana, Diogo; Fraga, Sónia; Gonçalves, Jorge. "Influence of microglia on nucleotide-induced astroglia proliferation". Paper presented in Purines 2008, 2008.
  29. Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "P2 receptor-subtypes in the modulation of reactive gliosis". Paper presented in Purines 2008, 2008.
  30. Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "P2Y receptor-subtypes in the modulation of noradrenaline release in rat brain cortex". Paper presented in Purines 2008, 2008.
  31. Quintas, Clara; Pestana, Diogo; Gonçalves, Jorge; Queiroz, Glória. "Pharmacological profile of P2 receptors involved in inhibition of noradrenaline release in rat brain cortical slices". Paper presented in 10ª Reunião Científica Nacional da Sociedade Portuguesa de Neurociências, 2007.
  32. Pestana, Diogo; Quintas, Clara; Oliveira, Jorge ; Gonçalves, Jorge; Queiroz, Glória. "Influence of microglia on astrocyte proliferation induced by nucleotides". Paper presented in 10ª Reunião Científica Nacional da Sociedade Portuguesa de Neurociências, 2007.
  33. Pestana, Diogo; Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "P2 receptors involved in the regulation of cortical astrocyte proliferation". Paper presented in 10ª Reunião Científica Nacional da Sociedade Portuguesa de Neurociências, 2007.
  34. Talaia, Carlos; Queiroz, Glória; Quintas, Clara; Morato, Manuela ; Gonçalves, Jorge. "Interaction between prejunctional facilitatory receptors and nitric oxide with a2-adrenoceptors on the modulation of noradrenaline release in rat mesenteric artery". Paper presented in 9ª Reunião Científica Nacional da Sociedade Portuguesa de Neurociências, 2005.
  35. Talaia, Carlos; Queiroz, Glória; Quintas, Clara; Gonçalves, Jorge. "Interaction between adenosine A2B receptors and a2-adrenoceptors on the modulation of noradrenaline release in the rat vas deferens: possible involvement of a group 2 adenylyl cyclase isoform". Paper presented in 4th Focused Meeting Cell Signalling, 2005.
  36. Queiroz, Glória; Quintas, Clara; Gonçalves, Jorge. "Evidence for involvement of protein kinases A and C on the adenosine A2B receptor-modulation of noradrenaline release in the prostatic portion of the rat vas deferens". Paper presented in 11th Meeting on Adrenergic Mechanisms, 2003.
Journal article
  1. Silva, Ana; Pinto, Cláudia; Cravo, Sara; Mota, Sandra; Rego, Liliana; Ratanji, Smeera; Quintas, Clara; et al. "Sustainable Skincare Innovation: Cork Powder Extracts as Active Ingredients for Skin Aging". Pharmaceuticals 18 1 (2025): 121. https://doi.org/10.3390/ph18010121.
    10.3390/ph18010121
  2. Mota, Sandra; Torres, Ana; Quintas, Clara; Peres, António M.; Ferreiro, Nuno; Cruz, Rebeca; Ferreira, Helena; Almeida, Isabel F.; Casal, Susana. "Characterization of Liquid Dosage Forms of Atenolol and Enalapril Maleate for Oral and Enteral Feeding Administration". Pharmaceuticals 17 8 (2024): 1052. http://dx.doi.org/10.3390/ph17081052.
    10.3390/ph17081052
  3. Mariana Ferreira-Duarte; Lilian Caroline Gonçalves Oliveira; Clara Quintas; Patricia Dias-Pereira; Teresa Sousa; Fernando Magro; Dulce Elena Casarini; Margarida Duarte-Araújo; Manuela Morato. "Angiotensin-converting enzymes 1 and 2 in the feces: presence and catalytic activity in the rat 2,4,6-trinitrobenzene sulfonic acid-induced model of colitis". Journal of Gastroenterology and Hepatology (2024): https://doi.org/10.1111/jgh.16541.
    10.1111/jgh.16541
  4. Ferreira-Duarte, Mariana; Oliveira, Lilian Caroline Gonçalves; Quintas, Clara; Dias-Pereira, Patricia; Sousa, Teresa; Magro, Fernando; Casarini, Dulce Elena; Duarte-Araújo, Margarida; Morato, Manuela. "Angiotensin-converting enzymes 1 and 2 in the feces: presence and catalytic activity in the rat 2,4,6-trinitrobenzene sulfonic acid-induced model of colitis". Journal of Gastroenterology and Hepatology 39 9 (2024): 1885-1894. https://doi.org/10.1111/jgh.16541.
    10.1111/jgh.16541
  5. Silva, Dany; Quintas, Clara; Gonçalves, Jorge; Fresco, Paula. "ß2-Adrenoceptor Activation Favor Acquisition of Tumorigenic Properties in Non-Tumorigenic MCF-10A Breast Epithelial Cells". Cells 13 3 (2024): 262. https://www.mdpi.com/2073-4409/13/3/262.
    Published
  6. Sandra Mota; Gonçalo P. Rosa; Maria do Carmo Barreto; Jorge Garrido; E Sousa; Cruz MT; Isabel Almeida; Clara Quintas. "Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents". Pharmaceuticals (2023): http://dx.doi.org/10.3390/ph17010055.
    10.3390/ph17010055
  7. Mariana Ferreira-Duarte; Lilian Caroline Gonçalves Oliveira; Clara Quintas; Marisa Esteves-Monteiro; Margarida Duarte-Araújo; Teresa Sousa; Dulce Elena Casarini; Manuela Morato. "ACE and ACE2 catalytic activity in the fecal content along the gut". Neurogastroenterology & Motility (2023): https://doi.org/10.1111/nmo.14598.
    10.1111/nmo.14598
  8. Clara Quintas; J.Gonçalves; Glória Queiroz. "Involvement of P2Y1, P2Y6, A1 and A2A Receptors in the Purinergic Inhibition of NMDA-Evoked Noradrenaline Release in the Rat Brain Cortex". Cells (2023): http://dx.doi.org/10.3390/cells12131690.
    10.3390/cells12131690
  9. Allal, Bader-Edine; Bounaama, Abdelkader; Silva, Dany; Quintas, Clara; Dahlouk, Salim Ismail; Gonçalves, Jorge; Djerdjouri, Bahia. "Long-term 1,2-dimethylhydrazine triggers pathological remodeling of colon mucosa through repression of sestrin2, nuclear factor (erythroid-derived 2)-like 2, and sirtuin4 stimulating mitochondrial stress and metabolic reprogramming". Naunyn-Schmiedeberg's Archives of Pharmacology (2023): http://dx.doi.org/10.1007/s00210-023-02403-x.
    10.1007/s00210-023-02403-x
  10. Dany Silva; Katarzyna Kacprzak; Clara Quintas; J.Gonçalves; Paula Fresco. "Activation of ß-Adrenoceptors Promotes Lipid Droplet Accumulation in MCF-7 Breast Cancer Cells via cAMP/PKA/EPAC Pathways". International Journal of Molecular Sciences (2023): http://dx.doi.org/10.3390/ijms24010767.
    10.3390/ijms24010767
  11. Silva, Dany; Quintas, Clara; Gonçalves, Jorge; Fresco, Paula. "Contribution of adrenergic mechanisms for the stress-induced breast cancer carcinogenesis". Journal of Cellular Physiology (2022): http://dx.doi.org/10.1002/jcp.30707.
    10.1002/jcp.30707
  12. Amaro, F.; Silva, Dany; Reguengo, Henrique; Oliveira, José C; Quintas, Clara; Vale, Nuno; Gonçalves, Jorge; Fesco, Paula. Corresponding author: Gonçalves, Jorge. "ß-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catecholamine Production Similar to that of Tumorigenic MCF-7 Cells.". International journal of molecular sciences (2020): https://europepmc.org/articles/PMC7672553.
    10.3390/ijms21217968
  13. Silva, Dany; Moreira, Diana; Cordeio-da-Silva, Anabela; Quintas, Clara; Gonçalves, Jorge; Fresco, Paula. Corresponding author: Gonçalves, Jorge. "Intracellular adenosine released from THP-1 differentiated human macrophages is involved in an autocrine control of Leishmania parasitic burden, mediated by adenosine A2A and A2B receptors". European journal of pharmacology (2020): https://doi.org/10.1016/j.ejphar.2020.173504.
    10.1016/j.ejphar.2020.173504
  14. Gonçalves, Jorge Manuel Moreira; Quintas, Clara; Silva, Dany; Queiroz, Glória; Fresco, Paula. "Unexpected Therapeutic Effects of Common Drugs: Lessons from 15 Years of Drug Repurposing". (2020): http://revista.farmacoterapia.pt/index.php/rpf/article/view/265.
    10.25756/rpf.v11i4.228
  15. Quintas, Clara; Vale, Nuno; Gonçalves, Jorge; Queiroz, Glória. "Microglia P2Y13 Receptors Prevent Astrocyte Proliferation Mediated by P2Y1 Receptors". Frontiers in Pharmacology 9 (2018): http://dx.doi.org/10.3389/fphar.2018.00418.
    Open access • Published • 10.3389/fphar.2018.00418
  16. Pinho, Brígida R; Reis, Sara D; Guedes-Dias, Pedro; Leitão-Rocha, Ana; Quintas, Clara; Valentão, Patrícia; Andrade, Paula B; Santos, Migue M; Oliveira, Jorge MA. "Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease". Pharmacological Research 103 (2016): 328-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954492311&partnerID=MN8TOARS.
    Published • 10.1016/j.phrs.2015.11.024
  17. Quintas, Clara; Pinho, Diana; Pereira, Clara; Saraiva, Lucília; Gonçalves, Jorge; Queiroz, Glória. "Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis". Journal of Neuroinflammation 11 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84910037446&partnerID=MN8TOARS.
    Published • 10.1186/s12974-014-0141-3
  18. Pinho, Diana; Quintas, Clara; Sardo, Filipa; Cardoso, Teresa M; Queiroz, Glória. "Purinergic modulation of norepinephrine release and uptake in rat brain cortex: Contribution of glial cells". Journal of Neurophysiology 110 11 (2013): 2580-2591. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888616553&partnerID=MN8TOARS.
    Published • 10.1152/jn.00708.2012
  19. Quintas, Maria. "P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation". Purinergic Signalling 7 2 (2011): 251-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960978463&partnerID=MN8TOARS.
    10.1007/s11302-011-9235-x
  20. Quintas, Clara; Fraga, Sónia; Gonçalves, Jorge; Queiroz, Glória. "Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: Mechanisms involved". Neuroscience 182 (2011): 32-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955484486&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2011.03.009
  21. Talaia, Carlos; Morato, Manuela; Quintas, Clara; Gonçalves, Jorge; Queiroz, Glória. "Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein". European Journal of Pharmacology 652 1-3 (2011): 33-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650912807&partnerID=MN8TOARS.
    Published • 10.1016/j.ejphar.2010.10.075
  22. Quintas, Clara; Fraga, Sónia; Gonçalves, Jorge; Queiroz, Glória. "The P2Y1 and P2Y12 receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues". Neurochemistry International 55 7 (2009): 505-513. http://www.scopus.com/inward/record.url?eid=2-s2.0-69349096676&partnerID=MN8TOARS.
    Published • 10.1016/j.neuint.2009.05.002
  23. Talaia, Carlos; Queiroz, Glória; Quintas, Clara; Gonçalves, Jorge. "Interaction between adenosine A2B-receptors and a2-adrenoceptors on the modulation of noradrenaline release in the rat vas deferens: Possible involvement of a group 2 adenylyl cyclase isoform". Neurochemistry International 47 6 (2005): 418-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-24144469367&partnerID=MN8TOARS.
    Published • 10.1016/j.neuint.2005.05.013
  24. Queiroz, Glória; Quintas, Clara; Talaia, Carlos; Gonçalves, Jorge. "Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens". Neuropharmacology 47 2 (2004): 216-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042660300&partnerID=MN8TOARS.
    Published • 10.1016/j.neuropharm.2004.03.015
Thesis / Dissertation
  1. "Modulation of astrogliosis by P2Y receptors through a dialogue between microglia and astrocytes". PhD, Universidade do Porto Faculdade de Farmácia, 2011.

Intellectual property

Provisional application for patent
  1. 2024. "Fecal biomarker for IBD which is a composite of fecal isoforms of ACE and ACE2 or each, as screening/detection method".
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/04 - 2024/12/08 Evaluation of cytotoxicity of topical formulations containing Crò thermal water for the delivery of ferulic acid
Supervisor

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/18 Changes in the P2Y12 purinoceptor expression and function in monocyte-derived microglial like cells from patients with Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS)
(Thesis) Main arguer
 Pedro Filipe dos Santos Beça (Master)