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Identification

Personal identification

Full name
Rui Filipe Cerqueira Malheiro

Author identifiers

Ciência ID
8718-3109-9CE6
ORCID iD
0000-0001-7421-2389

Addresses

  • Rua de Jorge Viterbo Ferreira, nº. 228, 4050-313, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Education
Degree Classification
2020/12/01 - 2024/12/01
Ongoing
PhD in Pharmaceutical Sciences - Molecular and Cellular Biology Speciality (Doutoramento)
Major in Molecular and Cellular Biology Speciality
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2021/10/19 - 2021/10/21
Concluded
Advance Course: Novel Challenges in Toxicology (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/11 - 2021/10/15
Concluded
Advanced Course: Introduction to digital bioimage analysis (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/09/15 - 2017/10/30
Concluded
MSc in Pharmaceutical Sciences (Mestrado integrado)
Universidade do Porto Faculdade de Farmácia, Portugal
Affiliation

Science

Category
Host institution
Employer
2017/11/15 - 2018/02/15 Research Trainee (Research) Università degli Studi di Bologna, Italy
Università degli Studi di Bologna Dipartimento di Farmacia e Biotecnologie, Italy

Others

Category
Host institution
Employer
2019/06/01 - 2019/11/30 Research Fellow Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2017/05/01 - 2017/09/01 Pharmacist (Internship) Farmácia Brito, Portugal
2017/03/01 - 2017/04/30 Pharmacist (Internship) Centro Hospitalar Universitário do Porto - Hospital de Santo António, Portugal
Projects

Grant

Designation Funders
2019/06/01 - 2019/12/31 Development of antidotes for Amanita phalloides intoxications, from in silico to the intoxicated patient
PTDC/DTP-FTO/4973/2014
Research Fellow
Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto, Portugal
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
PhD Student Fellow
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
PhD Student Fellow
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
PhD Student Fellow
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Malheiro, Rui F.; Gomes, Telma M.; Carmo, Helena; Carvalho, Felix; Silva, Joao P.. "Cannabinoids and psychosis: current challenges of mechanistic toxicology". In Toxicological Risk Assessment and Multi-System Health Impacts from Exposure, edited by Aristidis Tsatsakis, 601-615. Elsevier, 2021.
    10.1016/b978-0-323-85215-9.00020-9
Conference abstract
  1. Malheiro, R.F.; Carmo, H.; Carvalho, F.; Silva, J.P.. "The Synthetic Cannabinoids ADB-FUBINACA Modulate Mitochondrial Function and Dynamics at Biologically Relevant Concentrations During In Vitro Neurodifferentiation". Paper presented in Lisbon Addictions 2024, Lisbon, 2024.
    Accepted • 10.1016/j.etdah.2023.100104
  2. Malheiro, R.F.; Carmo, H.; Carvalho, F.; Silva, J.P.. "P09-10 The synthetic cannabinoid ADB-FUBINACA disrupts mitochondrial biogenesis of NG108-15 neuroblastoma cells during neuronal differentiation at human-relevant concentrations". Paper presented in 58th Congress of the European Societies of Toxicology (EUROTOX) 2024, Copenhagen, 2024.
    Published • 10.1016/j.toxlet.2024.07.454
  3. Fonseca, Catarina; Malheiro, Rui Filipe; Remião, Fernando; Silva, João Pedro; Silva, Renata. "Neurotoxicity evaluation of four structurally similar synthetic cathinones in a cholinergic neuronal model: a comparative analysis". Paper presented in III 1H-TOXRUN International Congress 2024, Porto, 2024.
    Published • https://doi.org/10.48797/sl.2024.250
  4. Malheiro, R.F.; Carmo, H.; Carvalho, F.D.; Silva, J.P.. "P21-24: THJ-2201, a synthetic cannabinoid, modulates mitochondrial function and dynamics during the neurodifferentiation of NG108-15 cells at biologically relevant concentrations". Paper presented in 57th Congress of the European Societies of Toxicology (Eurotox) 2023, Ljubljana, 2023.
    Published • 10.1016/s0378-4274(23)00831-7
  5. Malheiro, R.F.; Carmo, H.; Carvalho, F.; Silva, J.P.. "P16-10 The synthetic cannabinoid ADB-FUBINACA modulates mitochondrial activity and dynamics during neurodifferentiation of NG108-15 cells". Paper presented in Congress of the European Societies of Toxicology (Eurotox) 2022 - XVIth International Congress of Toxicology (ICT 2022), Maastricht, 2022.
    Published • 10.1016/j.toxlet.2022.07.600
  6. Malheiro, R.F.; Carmo, H.; Félix Carvalho, F.; Silva, J.P.. "In vitro evaluation of the effects of the synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA on mitochondrial function during neurodifferentiation". Paper presented in 56th Congress of the European Societies of Toxicology (EUROTOX) 2021, Copenhagen, 2021.
    Published • 10.1016/s0378-4274(21)00572-5
  7. Malheiro, Rui Filipe; Vera Marisa Costa; Maria de Lourdes Bastos; Félix Dias Carvalho. "In vitro toxicity of a-amanitin in human kidney cells and evaluation of protective effect of polymyxin B". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, 2019.
    Published • 10.3390/ecmc2019-06360
  8. João Alexandre; Rui Malheiro; Diana Dias Silva; Helena Carmo; Félix Dias Carvalho; João Pedro Silva. "Synthetic cannabinoids 5F-PB22 and THJ-2201 promote in vitro CB1 receptor-dependent neuronal differentiation at in vivo-relevant concentrations". Paper presented in 55th Congress of the European Societies of Toxicology (Eurotox) 2019, Helsínquia, 2019.
    Published
Conference poster
  1. Malheiro, R. F.; Carmo, Helena; Carvalho, F; Silva, João Pedro. "The synthetic cannabinoid ADB-FUBINACA disrupts mitochondrial biogenesis of NG108-15 neuroblastoma cells during neuronal differentiation at human-relevant concentrations". Paper presented in 58th Congress of the European Societies of Toxicology (Eurotox) 2024, 2024.
  2. Fonseca C.; Malheiro, Rui Filipe; Remião, Fernando; Silva, João Pedro; Silva, Renata. "Comparative Neurotoxicity Assessment of Four Structurally Similar Synthetic Cathinones Using a Cholinergic Neuronal Model". Paper presented in IJUP'24 - 17th Young Researchers Meeting of the University of Porto, 2024.
  3. Fonseca, Catarina; Malheiro, Rui Filipe; Remião, Fernando; Silva, João Pedro; Silva, Renata. "Neurotoxicity evaluation of four structurally similar synthetic cathinones in a cholinergic neuronal model: a comparative analysis". Paper presented in III 1H-TOXRUN International Congress 2024, 2024.
  4. Malheiro, R. F.; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "P21-24: THJ-2201, a synthetic cannabinoid, modulates mitochondrial function and dynamics during the neurodifferentiation of NG108-15 cells at biologically relevant concentrations". Paper presented in 57th Congress of the European Societies of Toxicology (Eurotox) 2023, 2023.
  5. Gomes, Telma M.; Malheiro, R. F.; Almeida, Mariana; Carmo, Helena; Silva, João Pedro; Carvalho, Félix. "The synthetic cannabinoid ADB-FUBINACA modulates epigenetic mechanisms during in vitro neuronal differentiation at biologically relevant concentrations". Paper presented in Lisbon Addictions 2022, 2022.
  6. Malheiro, R. F.; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "The synthetic cannabinoid ADB-FUBINACA modulates mitochondrial activity and dynamics during neurodifferentiation of NG108-15 cells". Paper presented in Congress of the European Societies of Toxicology (Eurotox) 2022 - XVIth International Congress of Toxicology (ICT 2022), 2022.
  7. Malheiro, R. F.; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "In vitro evaluation of the effects of the synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA on mitochondrial function during neurodifferentiation". Paper presented in 56th Congress of the European Societies of Toxicology (EUROTOX) 2021, 2021.
  8. Malheiro, R. F.; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "The synthetic cannabinoids ADB-FUBINACA and THJ-2201 affect mitochondrial function during neuronal differentiation of NG108-15 cells at human-relevant concentrations". Paper presented in III Jornadas Ibéricas de Toxicologia – UBIPharma, 2021.
  9. Malheiro, R. F.; Gomes, Telma M.; Galani, Myrto; da Silva, Diana Dias; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "ADB-FUBINACA, a synthetic cannabinoid, enhances in vitro neuronal differentiation at biologically relevant concentrations". Paper presented in 2021 SOT Annual Meeting, 2021.
  10. João Alexandre; Rui Malheiro; Helena Carmo; Félix Dias Carvalho; João Pedro Silva. "Synthetic Cannabinoids 5F-PB22 and THJ-2201 promote neuronal differentiation in neuroblastoma cells at biological relevant concentration". Paper presented in Lisbon Addictions 2019, 2019.
  11. João Alexandre; Rui Malheiro; Diana Dias Silva; Helena Carmo; Félix Dias Carvalho; João Pedro Silva. "Synthetic cannabinoids 5F-PB22 and THJ-2201 promote in vitro CB1 receptor-dependent neuronal differentiation at in vivo-relevant concentrations". Paper presented in 55th Congress of the European Societies of Toxicology (Eurotox) 2019, 2019.
Journal article
  1. Catarina Da Fonseca; Rui Malheiro; Fernando Remião; João Pedro Silva; Renata Silva. "Neurotoxicity Evaluation of Four Structurally Similar Synthetic Cathinones in a Cholinergic Neuronal Model: a Comparative Analysis". Scientific Letters (2024): Vol. 1 No. Sup 1 (20-Vol. 1 No. Sup 1 (20. https://publicacoes.cespu.pt/index.php/sl/article/view/250.
    10.48797/SL.2024.250
  2. RF Malheiro; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics". Pharmacological Research 187 (2022): 106603. http://dx.doi.org/10.1016/j.phrs.2022.106603.
    Published • 10.1016/j.phrs.2022.106603
  3. Roque-Bravo, Rita; Silva, Rafaela Sofia; Malheiro, Rui F.; Carmo, Helena; Carvalho, Félix; da Silva, Diana Dias; Silva, João Pedro. "Synthetic Cannabinoids: A Pharmacological and Toxicological Overview". Annual Review of Pharmacology and Toxicology 63 1 (2022): http://dx.doi.org/10.1146/annurev-pharmtox-031122-113758.
    Published • 10.1146/annurev-pharmtox-031122-113758
  4. Garcia, Juliana; Carvalho, Alexandra; das Neves, Ricardo Pires; Malheiro, Rui F.; Rodrigues, Daniela F.; Figueiredo, Pedro R.; Bovolini, Antonio; et al. "Antidotal effect of cyclosporine A against a-amanitin toxicity in CD-1 mice, at clinical relevant doses". Food and Chemical Toxicology 166 (2022): 113198. http://dx.doi.org/10.1016/j.fct.2022.113198.
    Published • 10.1016/j.fct.2022.113198
  5. Alexandre, João; Malheiro, Rui; Dias da Silva, Diana; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB1 Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations". International Journal of Molecular Sciences 21 17 (2020): 6277. http://dx.doi.org/10.3390/ijms21176277.
    Published • 10.3390/ijms21176277
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/02/07 The synthetic cannabinoid ADB-FUBINACA increases mitochondrial area and number within neurites, while disrupting their mobility during the neurodifferentiation of NG108-15 cells SPF 2025
Department of Biomedicine – Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto (Porto, Portugal)
2024/10/23 Human-relevant concentrations of synthetic cannabinoid THJ-2201 alter mitochondrial dynamics during neurodifferentiation Lisbon Addictions 2024
European Conference on Addictive Behaviours and Dependencies (Lisbon, Portugal)
2023/11/07 The synthetic cannabinoid ADB-FUBINACA modulates mitochondrial function and dynamics at biologically relevant concentrations during in vitro neurodifferentiation X International Conference on Novel Psychoactive Substances
International Society for the Study of Emerging Drugs (ISSED) (Abu Dhabi, United Arab Emirates)
2023/02/03 Increased neuronal differentiation of NG108-15 cells induced by the synthetic cannabinoid AMB-FUBINACA is accompanied by disrupted mitochondrial function SPF Meeting 2023
The Faculty of Medicine - Institute of Pharmacology and Experimental Therapeutics at the University of Coimbra (Coimbra, Portugal)
2022/11/23 The synthetic cannabinoids ADB-FUBINACA and THJ-2201 decrease mitochondrial activity and ATP levels during neurodifferentiation of NG108-15 cells Lisbon Addictions 2022
Portuguese General-Directorate for Intervention on Addictive Behaviours and Dependencies (SICAD) and European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (Lisbon, Portugal)
2020/02/07 ADB-Fubinaca enhances in vitro neuronal differentiation of Cannabinoid Receptor 1, at in vivo-relevant concentrations. SPF Meeting 2020
Universidade de Coimbra (Coimbra, Portugal)
2019/10/25 Synthetic cannabinoids 5F-PB22 and THJ-2201 promote neuronal differentiation in neuroblastoma cells at biologically relevant concentrations. Lisbon Addictions 2019
Portuguese General-Directorate for Intervention on Addictive Behaviours and Dependencies (SICAD) and European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (Lisbon, Portugal)
2019/02/06 Synthetic cannabinoids 5F-PB22 and THJ-2201 promote neuronal differentiation in neuroblastoma cells at in vivo relevant concentrations. SPF Meeting 2019
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019/02/06 - 2019/02/08 SPF Meeting 2019: A forum for scientific discussion on experimental pharmacological and toxicological research (2019/02/06 - 2019/02/08)
Congress (Member of the Organising Committee)
Universidade do Porto Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2025/01/30 - 2025/01/30 Training: Evaluation of scientific journals: the impact factor and other indices
Workshop
Evaluation of scientific journals: the impact factor and other indices
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/11/06 - 2023/11/08 X International Conference On Novel Psychoactive Substances, Abu Dhabi.
Conference
X International Conference On Novel Psychoactive Substances
International Society for the Study of Emerging Drugs (ISSED), United Arab Emirates
2023/09/19 - 2023/09/20 Worsk4U: Workshop in public speaking at UCIBIO-FFUP
Workshop
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2021/11/30 - 2021/11/30 V Symposium of the Portuguese Glial Network - Glial cells at the crossroad of health and disease was helded in Coimbra, on November 30th, as a satellite Meeting of the XVII Meeting of the Portuguese Society for Neuroscience.
Symposium
V Symposium of the Portuguese Glial Network: Glial cells at the crossroad of health and disease
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/06/13 - 2021/06/15 Advanced Course: Bioanalytical Methods for Neurochemical Research
Workshop
Bioanalytical Methods for Neurochemical Research
Universidade de Coimbra, Portugal
2019/04/12 - 2019/04/12 Biochemistry and Biophysics in the Post-Genomic Era: Biochemistry and Biophysics in the Post-Genomic
Conference
Biochemistry and Biophysics in the Post-Genomic Era
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/04/24 - 2017/04/24 Good Clinical Practices: How clinical trial are intended to be submitted to regulatory authorities.
Meeting
Good Clinical Practices
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2024/06/27 Seminar of the 2nd Cycle of Studies: Synthetic cathinones: from psychostimulation to the onset of psychiatric disorders
(Thesis) Main arguer
Catarina Teixeira da Fonseca (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2024/02/14 Curricular Unit Project I: Assessment of the impact of synthetic cannabinoids on communication between astrocytes and neurons during neurodevelopment
(Thesis) Main arguer
Joana de Almeida Fernandes (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
Distinctions

Award

2023 EUROTOX 2023 Travel Bursary
EUROTOX, Belgium