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Identification

Personal identification

Full name
Rui Filipe Cerqueira Malheiro

Citation names

  • RF Malheiro

Author identifiers

Ciência ID
8718-3109-9CE6

Addresses

  • Rua de Jorge Viterbo Ferreira, nº. 228, 4050-313, Porto, Porto, Portugal (Professional)
Education
Degree Classification
2020/12/01 - 2024/12/01
Ongoing
 PhD in Pharmaceutical Sciences (Doutoramento)
Major in Molecular and Cellular Biology Speciality
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2019/06/01 - 2019/12/31 Development of antidotes for Amanita phalloides intoxications, from in silico to the intoxicated patient
PTDC/DTP-FTO/4973/2014
Research Fellow
Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto, Portugal
 Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
PhD Student Fellow
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
PhD Student Fellow
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
PhD Student Fellow
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Malheiro, Rui F.; Gomes, Telma M.; Carmo, Helena; Carvalho, Felix; Silva, Joao P.. "Cannabinoids and psychosis: current challenges of mechanistic toxicology". In Toxicological Risk Assessment and Multi-System Health Impacts from Exposure, edited by Aristidis Tsatsakis, 601-615. Elsevier, 2021.
    10.1016/b978-0-323-85215-9.00020-9
Conference abstract
  1. Malheiro, R.F.; Carmo, H.; Carvalho, F.; Silva, J.P.. "P16-10 The synthetic cannabinoid ADB-FUBINACA modulates mitochondrial activity and dynamics during neurodifferentiation of NG108-15 cells". 2022.
    10.1016/j.toxlet.2022.07.600
  2. Malheiro, Rui Filipe; Vera Marisa Costa; Maria de Lourdes Bastos; Félix Dias Carvalho. "In vitro toxicity of a-amanitin in human kidney cells and evaluation of protective effect of polymyxin B". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, 2019.
    10.3390/ecmc2019-06360
  3. João Alexandre; Rui Malheiro; Diana Dias Silva; Helena Carmo; Félix Dias Carvalho; João Pedro Silva. "Synthetic cannabinoids 5F-PB22 and THJ-2201 promote in vitro CB1 receptor-dependent neuronal differentiation at in vivo-relevant concentrations". Paper presented in 55th Congress of the European Societies of Toxicology (Eurotox) 2019, Helsínquia, 2019.
    Published
Conference poster
  1. Telma M. Gomes; RF Malheiro; Mariana Almeida; Helena Carmo; Silva, João Pedro; Carvalho, Félix. "The synthetic cannabinoid ADB-FUBINACA modulates epigenetic mechanisms during in vitro neuronal differentiation at biologically relevant concentrations". Paper presented in Lisbon Addictions 2022, 2022.
  2. RF Malheiro. "In vitro evaluation of the effects of the synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA on mitochondrial function during neurodifferentiation". Paper presented in 56th Congress of the European Societies of Toxicology (EUROTOX 2021), 2021.
  3. RF Malheiro; Helena Carmo; Félix Dias Carvalho; João Pedro Silva. "The synthetic cannabinoids ADB-FUBINACA and THJ-2201 affect mitochondrial function during neuronal differentiation of NG108-15 cells at human-relevant concentrations". Paper presented in III Jornadas Ibéricas de Toxicologia – UBIPharma, 2021.
  4. RF Malheiro; Telma M Gomes; Myrto Galani; Diana Dias da Silva; Helena Carmo; Félix Dias Carvalho; João Pedro Silva. "ADB-FUBINACA, a synthetic cannabinoid, enhances in vitro neuronal differentiation at biologically relevant concentrations". Paper presented in 2021 SOT Annual Meeting, 2021.
  5. João Alexandre; Rui Malheiro; Helena Carmo; Félix Dias Carvalho; João Pedro Silva. "Synthetic Cannabinoids 5F-PB22 and THJ-2201 promote neuronal differentiation in neuroblastoma cells at biological relevant concentration". Paper presented in Lisbon Addictions 2019, 2019.
  6. João Alexandre; Rui Malheiro; Diana Dias Silva; Helena Carmo; Félix Dias Carvalho; João Pedro Silva. "Synthetic cannabinoids 5F-PB22 and THJ-2201 promote in vitro CB1 receptor-dependent neuronal differentiation at in vivo-relevant concentrations". Paper presented in 55th Congress of the European Societies of Toxicology (Eurotox) 2019, 2019.
Journal article
  1. RF Malheiro; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics". Pharmacological Research 187 (2022): 106603. http://dx.doi.org/10.1016/j.phrs.2022.106603.
    10.1016/j.phrs.2022.106603
  2. Roque-Bravo, Rita; Silva, Rafaela Sofia; Malheiro, Rui F.; Carmo, Helena; Carvalho, Félix; da Silva, Diana Dias; Silva, João Pedro. "Synthetic Cannabinoids: A Pharmacological and Toxicological Overview". Annual Review of Pharmacology and Toxicology 63 1 (2022): http://dx.doi.org/10.1146/annurev-pharmtox-031122-113758.
    10.1146/annurev-pharmtox-031122-113758
  3. Garcia, Juliana; Carvalho, Alexandra; das Neves, Ricardo Pires; Malheiro, Rui F.; Rodrigues, Daniela F.; Figueiredo, Pedro R.; Bovolini, Antonio; et al. "Antidotal effect of cyclosporine A against a-amanitin toxicity in CD-1 mice, at clinical relevant doses". Food and Chemical Toxicology 166 (2022): 113198. http://dx.doi.org/10.1016/j.fct.2022.113198.
    10.1016/j.fct.2022.113198
  4. R Malheiro; Carmo, H.; Félix Carvalho, F.; Silva, J.P.. "In vitro evaluation of the effects of the synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA on mitochondrial function during neurodifferentiation". Toxicology Letters 350 (2021): S140. http://dx.doi.org/10.1016/s0378-4274(21)00572-5.
    10.1016/s0378-4274(21)00572-5
  5. Alexandre, João; Malheiro, Rui; Dias da Silva, Diana; Carmo, Helena; Carvalho, Félix; Silva, João Pedro. "The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB1 Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations". International Journal of Molecular Sciences 21 17 (2020): 6277. http://dx.doi.org/10.3390/ijms21176277.
    10.3390/ijms21176277