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Rafaela Lacerda is an auxiliary researcher at the Department of Human Genetics in Instituto Nacional de Saúde Doutor Ricardo Jorge. She earned her PhD degree in Biology - Molecular Genetics in 2016 from Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia, studying the non-canonical mechanism of translation initiation of proteins with potential relevance in colorectal cancer and has been working in alternative translation mechanisms ever since, in proteins such as p53, UPF1, AGO1 and mTOR. She authored and co-authored several published journal articles. She attended and presented her work either oral communications or posters, at several scientific meetings in Portugal and abroad. She was awarded the best oral presentation in basic research in 2014, at the 19th annual meeting of the Portuguese Society for Human Genetics.
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Identification

Personal identification

Full name
Rafaela Lacerda Santos

Citation names

  • Lacerda, Rafaela

Author identifiers

Ciência ID
8618-9D93-F011
ORCID iD
0000-0002-5582-9823

Email addresses

  • rafaela.santos@insa.min-saude.pt (Professional)

Telephones

Telephone
  • 217526422 (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Russian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2023/09/11 - 2023/09/14
Concluded
 Bioinformatics Training School (Outros)
Karolinska Institutet, Sweden
2016/12/19
Concluded
 Programa Doutoral em Biologia — especialidade em Genética Molecular (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Non-canonical translation of proteins with potential relevance in colorectal cancer" (THESIS/DISSERTATION)
 Aprovado por unanimidade
2008/06/16
Concluded
 Biologia Celular e Biotecnologia (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estruturas secretoras em espécies hemiparasitas de Orobanchaceae da Flora Portuguesa" (THESIS/DISSERTATION)
 18
2002/09 - 2006/07/31
Concluded
 Biologia Celular e Biotecnologia (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 13
Affiliation

Science

Category
Host institution 		Employer
2021/05/03 - Current Auxiliary Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2019/02/01 - 2021/04/30 Contracted Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2016/10/01 - 2019/01/31 Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2009/09/01 - 2010/08/31 Research Trainee (Research) Instituto Gulbenkian de Ciência, Portugal
2008/11/01 - 2009/08/31 Research Trainee (Research) Instituto Gulbenkian de Ciência, Portugal
2005 - 2006 Research Trainee (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
2004 - 2005 Research Trainee (Research) Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2011/04/01 - 2016/06/30 Estudante Doutoramento Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Projects

Grant

Designation Funders
2022/10/04 - Current CA21154 - Translational control in Cancer European Network (TRANSLACORE)
CA21154
Researcher
Ongoing
2019/01/02 - 2021/04/30 Estudo mecanístico e aplicado das funções não-codantes do mRNA de p53 durante carcinogénese
PTDC/MED-ONC/32048/2017
Researcher
Fundação para a Ciência e a Tecnologia
2016/10/01 - 2019/01/31 Studying and targeting the non-canonical translation of p53 isoforms during stress and carcinogenesis
PTDC/BIM ONC/ 4890 2014
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/01/01 - 2019/12/31 Instituto de Biosistemas & Ciências Integrativas
UID/Multi/04046/2019
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade do Minho, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Biosystems & Integrative Sciences Institute
UID/Multi/04046/2019
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade do Minho, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Lacerda, Rafaela; Menezes, Juliane; Candeias, Marco M.. "Alternative Mechanisms of mRNA Translation Initiation in Cellular Stress Response and Cancer". In Advances in Experimental Medicine and Biology, 117-132. Springer International Publishing, 2019.
    Published • 10.1007/978-3-030-19966-1_6
Conference abstract
  1. Lacerda, Rafaela. "LEARNING FROM MRNA: THE RELEVANCE OF THE TUMOUR SUPPRESSOR PROTEIN UPF1’S INTERNAL RIBOSOME ENTRY SITE-MEDIATED TRANSLATION IN TUMORIGENESIS". Paper presented in 25th annual meeting of the Portuguese Society of Human Genetics, 2022.
Conference poster
  1. Ramalho, Ana Catarina; Lacerda, Rafaela; Luisa Romao; Candeias, Marco M. Corresponding author: Candeias, Marco M. "Translational Control of delta160p53 Keeps the Dark Side of TP53 in Check". Paper presented in 27th Annual Meeting SPGH, 2023.
  2. Ramalho, Ana Catarina; López-Iniesta, Maria José; Lacerda, Rafaela; Parkar, Shrutee N.; Luisa Romao; Candeias, Marco M. "The integrated stress response releases the oncoprotein in TP53". Paper presented in III ASPIC-ASEICA International Meeting, 2023.
  3. Ramalho, Ana Catarina; López-Iniesta, Maria José; Lacerda, Rafaela; Parkar, Shrutee N.; Luisa Romao; Candeias, Marco M. "The p53 short isoforms are activated by the integrated stress response to enhance survival in wild-type p53 cancer cell lines". Paper presented in Annual Congress of the European Association for Cancer Research, 2023.
  4. Ramalho, Ana Catarina; Filipa da Silva Rita; Jingyuan Zhao; Maria José López-Iniesta; Lacerda, Rafaela; Luisa Romao; Marco M Candeias. "Characterization of an oncogenic isoform of TP53: delta160p53". Paper presented in 25th Annual Meeting of the Portuguese Society of Human Genetics, 2021.
  5. Lacerda, Rafaela; Pereira Bruna; Menezes Juliana; Marques-Ramos A; Rita Neves Ana; Candeias MM; Romão, Luísa. "Translational switch during integrated stress response: the examples of p53 and UPF1". Paper presented in 25th Annual Meeting of the RNA Society, 2020.
  6. Lacerda, Rafaela; Juliane Menezes; Luísa Romão. "Human AGO1 5'UTR mediates an eIF4G-enhanced but cap-independent mechanism of translation initiation". Paper presented in Dia do jovem investigador do Instituto Ricardo Jorge, 2017.
  7. Neves, Ana Rita; Lacerda, Rafaela; Marques-Ramos, Ana; Romão, Luísa; Matsuda, M; Candeias, Marco. "Shorter p53 isoform expression through na Internal Ribosome Entry Site (IRES) in p53 mRNA". Paper presented in 21ª Reunião Anual Sociedade Portuguesa de Genética Humana. Genética da Medicina Personalizada: Cancro e Doenças Raras, 2017.
  8. Marques-Ramos A; Menezes, Juliane; Candeias, Marco; Willcocks, Mariam; Lacerda, Rafaela; Teixeira, Alexandre; Locker, Nicola; Romão, Luísa. "The human mTOR transcript allows cap-independent translation that insures its expression and function during inhibition of global translation". Paper presented in EMBO| EMBL Symposium: The Complex Life of mRNA, 2016.
  9. Lacerda, Rafaela; Menezes, Juliane; Marques-Ramos, Ana; Teixeira, Alexandre; Romão, Luísa. "Human UPF1 translation initiation is regulated by a cap-independent mechanism". Paper presented in 19ª Reunião da Sociedade Portuguesa de Genética Humana, 2015.
  10. Marques-Ramos A; Menezes, Juliane; Lacerda, Rafaela; Teixeira, Alexandre; Romão, Luísa. "Translational inhibitory conditions and mechanistic target of rapamycin (mTOR) protein expression ¿ an internal ribosome entry site (IRES) solves the problem". Paper presented in Translation UK 2014, 2014.
  11. Marques-Ramos, Ana; Menezes, Juliane; Lacerda, Rafaela; Teixeira, Alexandre; Romão, Luísa. "Identification of an IRES element in the human mTOR transcript: its structural and functional features". Paper presented in The 19th Annual Meeting of the RNA Society, 2014.
  12. Lacerda, Rafaela; Marques-Ramos, Ana; Teixeira, Alexandre; Romão, Luísa. "The expression of UPF1 is regulated by a cap-independent translation initiation mechanism and a cryptic promoter within its 5¿ untranslated region". Paper presented in 18ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2014.
  13. Lacerda, Rafaela; Marques-Ramos, Ana; Teixeira, Alexandre; Romão, Luísa. "Human UPF1: a cap-independent translation initiation mechanism and a cryptic promoter regulate its gene expression in cancer cells". Paper presented in 1st ASPIC International Congress., 2014.
  14. Lacerda, Rafaela; Marques-Ramos, Ana; Teixeira, Alexandre; Romão, Luísa. "Human Argonaute 1 5' untranslated region can mediate cap-independent translation initiation via an internal ribosome entry site". Paper presented in The 19th Annual Meeting of the RNA Society, 2014.
  15. Lacerda, Rafaela; Marques-Ramos, Ana; Teixeira, Alexandre; Romão, Luísa. "Analysis of the 5' untranslated region of human UPF1 mRNA indicates both cryptic promoter and internal ribosome entry site activity". Paper presented in The 19th Annual Meeting of the RNA Society, 2014.
  16. Lacerda, Rafaela; Marques-Ramos, Ana; Teixeira, Alexandre; Romão, Luísa. "The 5¿ untranslated region of human UPF1 mRNA shows both internal ribosome entry site and cryptic promoter activities". Paper presented in 17ª Reunião Anual Sociedade Portuguesa de Genética Humana, 2013.
  17. Marques-Ramos, Ana; Teixeira, Alexandre; Lacerda, Rafaela; Romão, Luísa. "Cap-independent translation regulation of mammalian target of rapamycin (mTOR)". Paper presented in The 18th annual meeting of the RNA Society, 2013.
  18. Lacerda, Rafaela; Marques-Ramos, Ana; Teixeira, Alexandre; Romão, Luísa. "Analysis of human Argonaute 1 5¿ untranslated region shows internal ribosome entry site activity". Paper presented in EMBO Conference Series: Protein Synthesis and Translational Control, 2013.
  19. Marques-Ramos A; Rafaela Lacerda; Alexandre Teixeira; Luisa Romao; Marques-Ramos, Ana; Lacerda, Rafaela; Teixeira, Alexandre; Romão, Luísa. "Internal ribosome entry site-mediated translational regulation of mammalian target of rapamycin (mTOR) in stress conditions". Paper presented in EMBO Conference Series: Protein Synthesis and Translational Control, 2013.
  20. Marques-Ramos, Ana; Lacerda, Rafaela; Teixeira, Alexandre; Romão, Luísa. "The 5´ Untranslated Region of the mammalian Target of Rapamycin mRNA Harbors an Internal Ribosome Entry Site". Paper presented in 16ª Reunião Anual Sociedade Portuguesa de Genética Humana, 2012.
  21. Marques-Ramos, Ana; Teixeira, Alexandre; Lacerda, Rafaela; Romão, Luísa. "Different Bcl2 transcripts coding the same protein have different posttranscriptional control mechanisms". Paper presented in 15ª Reunião da Sociedade Portuguesa de Genética Humana, 2011.
Journal article
  1. García-Moreno, Juan F.; Lacerda, Rafaela; da Costa, Paulo J.; Pereira, Marcelo; Gama-Carvalho, Margarida; Matos, Paulo; Romão, Luísa. "DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway". Cellular and Molecular Life Sciences 80 7 (2023): http://dx.doi.org/10.1007/s00018-023-04833-5.
    10.1007/s00018-023-04833-5
  2. Maria José López-Iniesta; Shrutee N. Parkar; Ana Catarina Ramalho; Rafaela Lacerda; Inês F. Costa; Jingyuan Zhao; Luísa Romão; Marco M Candeias. "Conserved Double Translation Initiation Site for ¿160p53 Protein Hints at Isoform’s Key Role in Mammalian Physiology". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/24/15844.
    10.3390/ijms232415844
  3. Rita Marques; Rafaela Lacerda; Luísa Romão. "Internal Ribosome Entry Site (IRES)-Mediated Translation and Its Potential for Novel mRNA-Based Therapy Development". Biomedicines (2022): https://www.mdpi.com/2227-9059/10/8/1865.
    10.3390/biomedicines10081865
  4. "Proceedings of the 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH – Sociedade Portuguesa de Genética Humana)". Medicine 100 4 (2021): e23585. http://dx.doi.org/10.1097/md.0000000000023585.
    Open access • Published • 10.1097/md.0000000000023585
  5. Gomes-Duarte A; Lacerda R; Menezes J; Romão L; Gomes-Duarte, Andreia; Lacerda, Rafaela; Menezes, Juliane; Romão, Luísa. "eIF3: a factor for human health and disease.". RNA biology (2018): http://europepmc.org/abstract/med/29099306.
    10.1080/15476286.2017.1391437
  6. Siefers Alves, Inês; Condinho, Manuel; Custódio, Sónia; Pereira, Bruna; Fernandes, Rafael; Gonçalves, Vânia; da Costa, Paulo J.; et al. "Genetics of personalized medicine: cancer and rare diseases". Cellular Oncology 41 3 (2018): 335-341. http://hdl.handle.net/10400.18/5978.
    10.1007/s13402-018-0379-3
  7. Lacerda R; Menezes J; Romão L; Lacerda, Rafaela; Menezes, Juliane; Romão, Luísa. "More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer.". Cellular and molecular life sciences : CMLS (2017): http://europepmc.org/abstract/med/27913822.
    10.1007/s00018-016-2428-2
  8. Marques-Ramos, Ana; Romão, Luísa; Candeias, Marco; Menezes, Juliane; Lacerda, Rafaela; Willcocks, M.; Teixeira, Alexandre; et al. "Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition". RNA (New York, N.Y.) (2017): http://hdl.handle.net/10400.18/4859.
    10.1261/rna.063040.117
Preprint
  1. López-Iniesta, Maria José; Lacerda, Rafaela; Ramalho, Ana Catarina; Parkar, Shrutee N.; Marques-Ramos, Ana; Pereira, Bruna; Miyawaki, Lina; et al. "Internal Translation of p53 Oncoproteins During Integrated Stress Response Confers Survival Advantage on Cancer Cells". 2023. http://dx.doi.org/10.1101/2023.03.03.531004.
    10.1101/2023.03.03.531004
Thesis / Dissertation
  1. Santos, Rafaela Lacerda. "Non-canonical translation initiation of proteins with potential relevance in colorectal cancer". PhD, 2016. http://hdl.handle.net/10362/20225.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/09/12 DIS3L2 promotes oncogenic features of colorectal cancer cells through the mTOR pathway School of Translational Control of the TumorMicroenvironment and of Immunological Checkpoints
TRANSLACORE (Milan, Italy)
2024/01/29 Internal ribosome entry site-mediated translation of UPF1 contributes to its oncogenic role in colorectal cancer 3rd Webinar for early career investigators
TRANSLACORE - Translational Control in Cancer European Network (CA21154)
2023/03/20 Translational switch during integrated stress response promotes oncogenic switch in p53 TRANSLACORE Lisbon Meeting
2020/11/20 THE TUMOR SUPPRESSOR P53 ACQUIRES ONCOGENIC FUNCTIONS DUE TO A TRANSLATIONAL SWITCH DURING INTEGRATED STRESS RESPONSE 24th annual meeting Sociedade Portuguesa de Genética Humana
Sociedade POrtuguesa de Genética Humana (Lisboa, Portugal)
2018/11/15 Common p53 mutations induce IRES-mediated translation of oncogenic shorter p53 isoforms 22nd anual meeting of Portuguese Society for Human Genetics
Portuguese Society for Human Genetics (Porto, Portugal)
2017/11/17 IRES-dependent translation of shorter p53 isoforms is affected by mutations in p53 21st annual meeting of the Portuguese Society for Human Genetics
2017 Human mTOR mRNA allows cap-independent translation that insures its expression and function during inhibition of global translation
2017 Non-canonical translation initiation of proteins with potential relevance in colorectal cancer
2016 The human mTOR transcript allows cap-independent translation that insures its expression and function during inhibition of global translation
2016 Non-canonical translation initiation in the human UPF1 mRNA
2014 The expression of UPF1 is regulated by a cap-independent translation initiation mechanism and a cryptic promoter within its 5’ untranslated region
2013 Cap-independent translation regulation of mammalian target of rapamycin (mTOR)
2012 MLH1 and DCC, two genes involved in colorectal cancer, have different mechanisms of translation initiation

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/10/01 - Current The association between the unfolded protein response, nonsense-mediated mRNA decay, and human disease
Supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/10/01 - Current The mechanism of nonsense-mediated mRNA decay and its players
Supervisor
 Biologia Molecular e Genética
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/10/01 - Current Internal ribosome entry site(IRES)-mediated protein synthesis in colorretal cancer progression
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/10/01 - Current Non-canonical translation initiation of Argonaut 1 and its implications in tumorigenesis
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/10/01 - Current Mechanism of nonsense-mediated mRNA decay: Dis3l2
Supervisor of Catarina Isabel Ferreira Subtil
 Molecular Biology and Genetics (Master)
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2022/10/01 - Current In vitro functional studies of variants in the PCSK9 gene
Supervisor
 Biochemistry (Master)
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2020/11/01 - Current Unravelling the oncogenic functions and regulation of the most conserved p53 isoform, d160p53: a study in cancer cells and transgenic mice
Co-supervisor of Ana Catarina Campos Ramalho
 PhD (PhD)
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2021/10/01 - 2023/02 A tradução não-canónica da proteína UPF1 (up-frameshift 1) e a sua relevância na tumorigénese do cancro colorretal
Supervisor
 Molecular Biology and Genetics (Master)
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/03/20 - 2023/03/21 TRANSLACORE Lisbon Meeting A in-person meeting with the participants in the COST action TRANSLACORE (2023/03/20 - 2023/03/21)
Meeting (Co-organisor)
2019/06 - 2021/11 Member of the creative and executive team for the exhibition "Genética Humana: do passado ao futuro" at Instituto Nacional de Saúde Doutor Ricardo Jorge (2019/12/17)
Exhibition (Co-organisor)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2017 - 2017/11/18 Member of the organising team of the 21st annual meeting of the Portuguese Society of Human Genetics (Hotel Aldeia dos Capuchos, Almada) (2017/11/16 - 2017/11/18)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de genética Humana, Portugal
2014 - 2014 Member of the organising team of the 18th annual meeting of the Portuguese Society of Human Genetics (Instituto de Medicina Molecular, Lisbon) (2014/11/19 - 2014/11/21)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de genética Humana, Portugal
2011 - 2011 Member of the organising team of the 15th annual meeting of the Portuguese Society of Human Genetics (Pavilhão do Conhecimento, Lisbon) (2011/11/17 - 2011/11/19)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de genética Humana, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/11/23 - 2023/11/25 NON-CANONICAL SYNTHESIS OF UPF1 PROTEIN CONTRIBUTES TO ITS ONCOGENIC ROLE IN COLORECTAL CANCER Poster presentation
Congress
 27th Annual Meeting of the Portuguese Society for Human Genetics
2023/09/22 - 2023/09/22 A iniciação não-canónica da síntese da proteína UPF1 contribui para a sua função oncogénica no cancro colo-rectal Poster presentation
Meeting
 5.º Encontro Nacional de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2023/01/26 - 2023/01/27 Internal ribosome entry site-mediated translation of UPF1 contributes to its oncogenic role in colorectal cancer Poster presentation
Congress
 RNA in Disease - IX ptRNA meeting
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2022/11/17 - 2022/11/19 UPF1 has oncogenic functions in colorectal cancer Poster Highlight presentation
Congress
 26th annual meeting of the Portuguese Society for Human Genetics
2021/11/18 - 2021/11/19 Learning from mRNA: the relevance of the tumour suppressor protein UPF1’s internal ribosome entry site-mediated translation in tumorigenesis
Congress
 25th annual meeting of the Portuguese Society of Human Genetics
Sociedade Portuguesa de Genética Humana, Portugal
2021/10/14 - 2021/10/15 Poster presentation "UPF1 internal ribosome entry site-mediated translation and its importance in tumorigenesis"
Meeting
 II ASPIC-ASEICA International Meeting
2021/09/07 - 2021/10/10 Poster presentation "Unraveling the role of internal ribosome entry site (IRES) mediated translation in human UPF1 expression and function"
Congress
 Protein Synthesis and Translational Control
European Molecular Biology Laboratory, Germany
2021/09/24 - 2021/09/24 Poster presentation "O mecanismo alternativo de síntese proteica da proteína UPF1 e a sua relevância na tumorigénese"
Conference
 III Encontro de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021/09/24 - 2021/09/24 DNA, RNA, proteínas e outras "criaturas" fantásticas: Presente e Futuro em Mudança
Festival
 Noite Europeia dos Investigadores 2021 | Ciência para o clima
2021/07/08 - 2021/07/09 Poster presentation "UPF1 5'UTR internal ribosome entry site mediated translation initiation: the use of antisense oligonucleotides to modulate its activity and its effect on UPF1 functions"
Symposium
 1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal – OTP2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/03/02 - 2020/03/04 EACR-AACR Basic and Translational Research Conference in partnership with ASPIC Tumor Microenvironment Lisbon, Portugal | 02-04 March 2020
2017/11/16 - 2017/11/18 Brand New World of Translation Poster presentation
Meeting
 21st annual meeting of Portuguese Society for Human Genetics
2017/11/16 - 2017/11/18 Human AGO1 5’UTR mediates an elF4G-enhanced but cap-independent mechanism of translation initiation Poster presentation
Meeting
2017/05/31 - 2017/06/03 Characterization of an Internal Ribosome Entry Site (IRES) in p53 mRNA Poster presentation
Meeting
2017/05/31 - 2017/06/03 Expression of human UPF1 is regulated by a cap-independent translation initiation mechanism Poster presentation
Meeting
 22nd Annual Meeting of the RNA Society
2017/05/31 - 2017/06/03 p53 mutations influence IRES-dependent expression of p53 isoforms Poster presentation
Meeting
 22nd Annual Meeting of the RNA Society
2015 - 2015 Human UPF1 translation initiation is regulated by a cap-independent mechanism Poster presentation
2014 - 2014 Analysis of the 5’ untranslated region of human UPF1 mRNA indicates both cryptic promoter and internal ribosome entry site activity Poster presentation
2014 - 2014 Human Argonaute 1 5’ untranslated region can mediate cap-independent translation initiation via an internal ribosome entry site Poster presentation
2014 - 2014 Human UPF1: a cap-independent translation initiation mechanism and a cryptic promoter regulate its gene expression in cancer cells Poster presentation
2014 - 2014 Identification of an IRES element in the human mTOR transcript: its structural and functional features Poster presentation
2014 - 2014 Translational inhibitory conditions and mechanistic target of rapamycin (mTOR) protein expression – an internal ribosome entry site (IRES) solves the problem Poster presentation
2013 - 2013 Analysis of human Argonaute 1 5’ untranslated region shows internal ribosome entry site activity Poster presentation
2013 - 2013 Internal ribosome entry site-mediated translational regulation of mammalian target of rapamycin (mTOR) in stress conditions Poster presentation
2013 - 2013 The 5’ untranslated region of human UPF1 mRNA shows both internal ribosome entry site and cryptic promoter activities Poster presentation
2012 - 2012 The same Bcl2 protein is produced by two human Bcl2 transcript isoforms that present different mechanisms of post-transcriptional regulation Poster presentation
2012 - 2012 The 5´ Untranslated Region of the mammalian Target of Rapamycin mRNA Harbors an Internal Ribosome Entry Site Poster presentation

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/09/18 Studying and targeting the functions of p53 mRNA in carcinogenesis
(Thesis) Main arguer
 Beatriz Damasceno (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/01/15 - 2024/02/04 Frontier in Molecular Biosciences (2296-889X)

Interview (tv / radio show)

Program Topic
2021/06/22 - 2021/06/22 Eight o'clock news, TVI24 Live stream from a COVID-19 test crew, in which I was working as a volunteer, representing Instituto Nacional de Saúde Doutor Ricardo Jorge
Distinctions

Award

2014 Basic Research Award for best oral communication at the 18th Annual Meeting of the Portuguese Society for Human Genetics, 2014
Sociedade Portuguesa de genética Humana, Portugal