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Marta Daniela Costa graduated in Biology (scientific domain) in 2006 by University of Porto. In 2013, she finished her PhD in human evolutionary genetics by University of Leeds, in United Kingdom. Since then, her research work has been focused in the study of a genetic neurodegenerative disease known as Machado-Joseph disease (MJD) or Spinocerebellar ataxia 3 (SCA3). Using a transgenic C. elegans model of this disorder, she aims to identify and to characterize genetic modifiers of MJD with potential to be targeted therapeutically, adding insights to a disorder that remains without any effective cure. In this effort to create therapeutic strategies that could reach the patients, Marta D. Costa also participates in studies to find novel biactive compounds, namely from plant extracts, to counteract neurodegeneration in several C. elegans models. Marta D. Costa received a distinction from National Ataxia Foundation to pursue her research in MJD. She has participated in the training of undergraduated and MSc students. Marta D. Costa published a total of 30 original articles representing more than 900 citations and a h-índex of 14 (source: Scopus).
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Identification

Personal identification

Full name
Marta Daniela Araújo da Costa

Citation names

  • Costa, Marta Daniela

Author identifiers

Ciência ID
8517-D97B-5879
ORCID iD
0000-0002-6247-0548

Email addresses

  • martabiologia@gmail.com (Personal)

Telephones

Telephone
  • 253604839 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4705-057, Braga, Braga, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Genetics and Heredity
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2015/10/01 - 2019/03/13
Concluded
 Genetic modifiers of polyglutamine diseases (Pós-doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009/02/01 - 2013/06/17
Concluded
 Genetics (Doctor of Philosophy)
Major in Human evolutionary genetics
University of Leeds Faculty of Biological Sciences, United Kingdom
"Genetic characterisation of the Early Upper Palaeolithic settlement of Europe by modern humans" (THESIS/DISSERTATION)
 Pass with minor deficiencies
2006/09/15 - 2008/12/15
Concluded
 Environmental Sciences (Mestrado)
Major in Environmental quality; microbiology
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
"Microbiological characterization of wastewater and Phragmites australis rizhosphere in a constructed wetland from Parada de Bouro, Portugal" (THESIS/DISSERTATION)
 Muito Bom (Bom, Bom com distinção, Muito Bom)
2002/09/01 - 2006/07/31
Concluded
 Biology (Licenciatura)
Major in Scientific
Universidade do Porto Faculdade de Ciências, Portugal
"Toxoplasma gondi: seroprevalência em ovinos e gatos de Portugal; serotipagem com recurso a péptidos sintéticos (GRA6)." (THESIS/DISSERTATION)
 15 (0-20)
1999 - 2002
Concluded
 High School Diploma (Ensino secundário)
Externato Infante D. Henrique/Alfacoop, Portugal
Affiliation

Science

Category
Host institution 		Employer
2019/03/14 - 2025/03/13 Contracted Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/08/01 - 2019/03/13 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007/08/01 - 2013/01/31 Research Assistant (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2006/02/01 - 2006/07/31 Research Trainee (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2009/09/15 - 2010/02/28 Invited Assistant (University Teacher) University of Leeds Faculty of Biological Sciences, United Kingdom
University of Leeds Faculty of Biological Sciences, United Kingdom

Others

Category
Host institution 		Employer
2018/07/01 - 2025 Technician of the genetic diagnostic service Universidade do Minho, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Grant

Designation Funders
2015/10/01 - 2019/03/13 Genetic modifiers of Machado-Joseph disease
SFRH/BPD/101925/2014
Post-doc Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2009/02/01 - 2013/01/31 Genetic characterisation of the Early Upper Palaeolithic settlement of Europe by modern humans
SFRH/BD/48372/2008
PhD Student Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019 - Current Genetic screening for identification of novel therapeutic targets in Machado-Joseph disease
N/A
Post-doc
National Ataxia Foundation
2025/01/01 - 2027/12/31 New molecules harnessing targeted protein degradation for the treatment of Machado-Joseph disease
HR24-00578
Post-doc
2024/03/01 - 2025/02/28 DECODing the SERoTonergic circuitry in the Machado-Joseph disease mouse brain
NAF2024
Post-doc
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 National Ataxia Foundation
Ongoing
2018 - 2022 Whole-exome sequencing of discordant and concordant affected sib pairs in spinocerebellar ataxia type 3 (SCA3): a tool to identify novel modifier genes and highlight disrupted molecular pathways
PTDC/DTP-PIC/2638/2014
Other
Fundação para a Ciência e a Tecnologia
2013/08/01 - 2015/09/30 Proteostasis as a link between longevity pathways and neurodegenerative diseases
PTDC/NEU-BEN/0125/2012
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2013/01/31 Genetic and chronological characterization of the European settlement of Europe by modern humans during the Early Upper Palaeolithic
PTDC/CS-ANT/113832/2009
PhD Student Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2009/01/31 Longevity in humans with an african origin - a genetic perspective
PTDC/AFR/71422/2006
Research Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Vilas-Boas Campos, Daniela; Fernandes, Jorge Humberto; Costa, Marta Daniela; Maciel, Patrícia; Andreia Teixeira-Castro. "Advancing Proteostasis-enhancing Therapies: A Novel Assay for Drug Discovery in Machado-Joseph disease". Paper presented in MJD Foundation Conference -Bridging Science & Service: Research and culturally responsive healthcare for cerebellar ataxia, Darwin, 2025.
  2. Vilasboas-Campos, Daniela; Fernandes, Jorge H.; Pereira-Sousa, Joana; Joana Lopes; Liliana Costa-Meireles; Bruna Ferreira-Lomba; Da Silva, Jorge Diogo; Costa, Marta Daniela; r«. "Establishment of a Novel Assay to identify drugs that enhance protein homeostasis: towards treatment of Neurodegenerative Diseases". Paper presented in SPDMov - Sociedade Portuguesa das Doenças do Movimento: Doenças do Movimento Tratáveis, Ofir, 2024.
Conference paper
  1. Afonso, C.; Alshamali, F.; Pereira, J.B.; Fernandes, V.; Costa, M.; Pereira, L.. "mtDNA diversity in Sudan (East Africa)". Paper presented in Forensic Science International, 2008.
    Published • 10.1016/j.fsigss.2007.10.118
Conference poster
  1. Vilasboas-Campos, D; Fernandes, J. H; Costa, Marta Daniela; Pereira-Sousa, J.; Lopes, J; Meireles-Costa; L; Ferreira-Lomba, B; et al. "Establishment of a Novel Assay to identify drugs that enhance protein homeostasis: towards treatment of spinocerebellar ataxias". Paper presented in International Congress for Ataxia Research (ICAR 2024), 2024.
  2. Costa, Marta Daniela; Vilasboas-Campos, Daniela; Fernandes, Jorge H.; Vieira, Carmen; Nunes, Lídia; Teixeira-Castro, Andreia; Maciel, Patrícia. "Novel genetic modifiers of MJD/SCA3: an EMS screening in a C. elegans model of the disease". Paper presented in SPDMov (Portuguese Society of Movement Disorder) – Genetics of Movement Disorders, 2024.
  3. Costa, Marta Daniela; Vilasboas-Campos, Daniela; Fernandes, Jorge H.; Vieira, Carmen; NUNES, LÍDIA; Teixeira-Castro, Andreia; Maciel, Patrícia. "Novel genetic modifiers of MJD/SCA3: an EMS screening in a C. elegans model of the disease". Paper presented in International Congress for Ataxia Research 2024, 2024.
  4. Vilasboas-Campos, Daniela; Lopes, J; Ferreira-Lomba, Bruna; DA SILVA, JORGE D.; Costa, Marta Daniela; et al. "Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Animal Organism Phenotypic Assay". Paper presented in EMBO Workshop: "Proteostasis: From translation to degradation"., 2023.
  5. Vilasboas-Campos, Daniela; Lopes, Joana; Bruna Ferreira-Lomba; Jorge Diogo Da Silva; Costa, Marta Daniela; Rodrigues A.I.; Sousa, A; et al. "Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Organism Phenotypic Assay.". Paper presented in EMBO Workshop: Proteostasis: From translation to degradation., 2023.
  6. Vilasboas-Campos, Daniela; Lopes, J; Ferreira-Lomba, Bruna; DA SILVA, JORGE D.; Costa, Marta Daniela; Maciel, Patrícia; Teixeira-Castro, Andreia. "FastProtAct - FAST-throughput phenotypic assay to identify compounds with PROTeostasis ACTivity.". Paper presented in International Society of Neurochemistry (ISN) and the European Society of Neurochemistry (ESN) meeting, 2023.
  7. Duarte-Silva, S; DA SILVA, JORGE D.; Monteiro-Fernandes, Daniela; Costa, Marta Daniela; Pereira-Sousa, Joana; Ferreira-Fernandes, Ana Rita; Rodrigues, Fernando; et al. "The glucocorticoid receptor as a biomarker and neuronal therapeutic target of a disease-improving bile acid in SCA3/MJD". Paper presented in ICVS retreat, 2023, 2023.
  8. Vilasboas-Campos, Daniela; Teixeira-Castro, Andreia; Lopes, Joana; Ferreira-Lomba, Bruna; Da Silva, Jorge D.; Costa, Marta Daniela; Rodrigues, Ana Isabel ; et al. "Identification of novel molecules with proteostasis enhancement activity using a whole-animal based fast-throughput phenotypic assay". Paper presented in 6th Symposium on Medicinal Chemistry, 2023.
  9. DA SILVA, JORGE D.; Duarte-Silva, S; Costa, Marta Daniela; Neves-Carvalho, Andreia; Raposo, Mafalda; Soares-Cunha, Carina; Correia, Joana; et al. "Glucocorticoid Receptor as a Biomarker and Neuronal Therapeutic Target of a Disease-Improving Bile Acid in SCA3/MJD". Paper presented in International Congress for Ataxia Research (ICAR) 2022, 2022.
  10. Vilasboas-Campos, Daniela; Fernandes, Jorge H.; Vieira, Carmen; Teixeira-Castro, Andreia; Maciel, Patrícia; Costa, Marta Daniela. "Novel genetic modifiers of SCA3/MJD: an EMS screening in a C. elegans model of the disease". Paper presented in International Congress for Ataxia Research (ICAR 2022), 2022.
  11. Fernandes, Jorge H.; Vilasboas-Campos, Daniela; Costa, Marta Daniela; Wang, Q; Dias, Alberto; Maciel, Patrícia; Fernandes, J; Vilasboas-Campos, D; Dias, A. "Neuroprotective effect of a Hemerocallis citrina extract in a C. elegans model of Machado-Joseph disease". Paper presented in International Congress for Ataxia Research (ICAR) 2022, 2022.
  12. Vilasboas-Campos, D; Lopes J; Bruna Ferreira-Lomba; DA SILVA, JORGE D.; Costa, Marta Daniela; Maciel, Patrícia; Castro, Andreia Cristiana Teixeira; et al. "Chemical screening for novel therapeutic target identification in Machado-Joseph disease". Paper presented in 35th ECNP Congress, 2022.
  13. Vilasboas-Campos, Daniela; Lopes, J; Ferreira-Lomba, Bruna; DA SILVA, JORGE D.; Costa, Marta Daniela; Maciel, Patrícia; Teixeira-Castro, Andreia; et al. "Development of a high-throughput phenotypic assay to screen for chemical enhancers of proteostasis activity in Caenorhabditis elegans". Paper presented in International Neuroscience Conference at the Federation of European Neuroscience Societies (FENS), 2022.
  14. Vieira, Carmen; Jalles, A.; Pereira-Sousa, Joana; Vilasboas-Campos, D; Mota, AF; Vasconcelos, S; Ferreira-Lomba, B; et al. "Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), Coimbra – Portugal., 2021.
  15. Costa, Marta Daniela. "Genetic modifiers of spinocerebellar ataxia 3/ Machado-Joseph disease (SCA3/MJD): the role of anti-aging genetic mutations". Paper presented in 23rd International C. elegans conference, 2021.
  16. Machado, Pedro; Wade, John; M. Mcginnity, T.. "Anti-aging genetic mutations impact differentially in Machado-Joseph disease". Paper presented in Strategies and tools for modulating pathologic protein self-assembly in proteionopathies, 2019.
    10.5220/0005169301690176
  17. Fonseca, MCM; Sediyama, MAN; Vilasboas-Campos, D; Bessa, C.; Costa, Marta Daniela; Maciel, Patrícia; Dias, Alberto. "Neuroprotective and antioxidant effects of Maranta arundinacea and Porophyllum ruderale in Caenorhabditis elegans". Paper presented in Food Chemistry Conference, 2019.
  18. Costa, Marta Daniela. "Genetic and pharmacological modifiers of ATXN3 proteotoxicity converge to antioxidant response pathways.". Paper presented in Ataxia Investigators Meeting 2018 (AIM 2018)., 2018.
  19. Costa, Marta Daniela. "Genetic anti-aging manipulations differentially modify disease manifestations and protein aggregation in a Caernohabditis elegans model of Machado-Joseph disease.". Paper presented in XV Meeting Portuguese Society of Neurosciences (SPN), 2017.
  20. Costa, Marta Daniela. "The effect of lifespan-increasing mutations in a C. elegans model of Machado-Joseph disease.". Paper presented in Ataxia Investigators Meeting 2015 (AIM 2015), 2015.
  21. Costa, Marta Daniela. "Link between longevity pathways and neurodegenerative diseases: the effect of mitochondrial lifespan-increasing mutations in a C. elegans model of Machado-Joseph disease.". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  22. Costa, Marta Daniela. "Palaeolithic Late Glacial expansions in Europe revealed through the fine-resolution characterisation of mtDNA haplogroup U8.". Paper presented in SMBE 2012, 2012.
  23. Costa, Marta Daniela. "MtDNA complete sequencing in African centenarians: the haplogroup/variant association and the golden mean to longevity.". Paper presented in XXXV Portuguese Genetics Conference, 2010.
  24. Costa, Marta Daniela. "Microbiological characterisation of wastewater and rizosphere on a constructed wetland in north of Portugal.". Paper presented in 11º Encontro Nacional de Ecologia., 2008.
  25. Costa, Marta Daniela. "On the difficulty of performing association studies with mtDNA: the case study of longevity.". Paper presented in 11st Meeting of the Portuguese Society of Human Genetics, 2007.
  26. Costa, Marta Daniela. "mtDNA complete sequences in centenarians from Tunisia.". Paper presented in Link-Age Meeting, 2007.
  27. Costa, Marta Daniela. "Toxoplasma gondii: seroprevalence in ovines from Vinhais, Trás – os – Montes". Paper presented in Dia do Jovem Investigador, 2006.
Journal article
  1. Marta Daniela Costa; Jorge Diogo Da Silva; Dulce Almeida; Joana Pereira-Sousa; Daniela Vilasboas-Campos; Jorge Humberto Fernandes; Andreia Teixeira-Castro; Patrícia Maciel. "Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3". Mechanisms of Ageing and Development (2025): http://dx.doi.org/10.1016/j.mad.2025.112064.
    10.1016/j.mad.2025.112064
  2. Jorge H. Fernandes; Marta Daniela Costa; Daniela Vilasboas-Campos; Bruna Ferreira-Lomba; Joana Pereira-Sousa; Qiong Wang; Andreia Teixeira-Castro; et al. "Therapeutic Effects of Hemerocallis citrina Baroni Extract on Animal Models of Neurodegenerative Diseases Through Serotonin and HLH-30/TFEB-Dependent Mechanisms". International Journal of Molecular Sciences (2025): http://dx.doi.org/10.3390/ijms26094145.
    10.3390/ijms26094145
  3. Chatterjee, Nivedita; González-Durruthy, Michael; Costa, Marta Daniela; Ribeiro, Ana R.; Vilas-Boas, Vânia; Vilasboas-Campos, Daniela; Maciel, Patrícia; Alfaro-Moreno, Ernesto. "Differential impact of diesel exhaust particles on glutamatergic and dopaminergic neurons in Caenorhabditis elegans: A neurodegenerative perspective". Environment International 186 (2024): 108597. http://dx.doi.org/10.1016/j.envint.2024.108597.
    10.1016/j.envint.2024.108597
  4. Duarte-Silva, S; DA SILVA, JORGE D.; Monteiro-Fernandes, Daniela; Costa, Marta Daniela; Neves-Carvalho, Andreia; Raposo, Mafalda; Soares-Cunha, Carina; et al. "Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3 (IF: 19.47)". The Journal of Clinical Investigation (2024):
    Published
  5. Luísa Carvalho; Fábio Pedroso de Lima; Mónica Cerqueira; Ana Silva; Olívia Pontes; Sofia Oliveira-Pinto; Sara Guerreiro; et al. "In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer". RSC Medicinal Chemistry (2024): https://doi.org/10.1039/D3MD00682D.
    10.1039/D3MD00682D
  6. Almeida, Filipa; Ferreira, Ildete L.; Naia, Luana; Marinho, Daniela; Vilaça-Ferreira, Ana Catarina; Costa, Marta D.; Duarte-Silva, Sara; Maciel, Patrícia; Rego, A. Cristina. "Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models of Machado-Joseph Disease (IF:7.6)". Cells 12 19 (2023): 2397. http://dx.doi.org/10.3390/cells12192397.
    Accepted • 10.3390/cells12192397
  7. Costa, Marta Daniela; Maciel, Patrícia. "Modifier pathways in polyglutamine (PolyQ) diseases: from genetic screens to drug targets (IF: 8.0)". Cellular and Molecular Life Sciences 79 5 (2022): http://dx.doi.org/10.1007/s00018-022-04280-8.
    10.1007/s00018-022-04280-8
  8. Ana Jalles; Cármen Vieira; Joana Pereira-Sousa; Daniela Vilas Boas da Silva Campos; Ana Francisca Mota; Sara Vasconcelos; Bruna Ferreira-Lomba; et al. "Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans (IF: 4.757)". Biomedicines (2022): https://www.mdpi.com/2227-9059/10/2/370.
    10.3390/biomedicines10020370
  9. Raposo, Mafalda; Bettencourt, Conceição; Melo, Ana Rosa Vieira; Ferreira, Ana F.; Alonso, Isabel; Silva, Paulo; Vasconcelos, João; et al. "Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing (IF: 6.1)". Neurobiology of Disease 162 (2022): 105578. http://dx.doi.org/10.1016/j.nbd.2021.105578.
    10.1016/j.nbd.2021.105578
  10. Da Silva, Jorge Diogo; Costa, Marta Daniela; Almeida, Bruno; Lopes, Fátima; Maciel, Patrícia; Teixeira-Castro, Andreia. "Case Report: A Novel GNB1 Mutation Causes Global Developmental Delay With Intellectual Disability and Behavioral Disorders (IF:4.003)". Frontiers in Neurology 12 (2021): http://dx.doi.org/10.3389/fneur.2021.735549.
    Accepted • 10.3389/fneur.2021.735549
  11. Pereira-Sousa, Joana; Ferreira-Lomba, Bruna; Bellver-Sanchis, Aina; Vilasboas-Campos, Daniela; Fernandes, Jorge H.; Costa, Marta D.; Varney, Mark A.; et al. "Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease (IF:6.68)". Neurobiology of Disease (2021): 105278. http://dx.doi.org/10.1016/j.nbd.2021.105278.
    10.1016/j.nbd.2021.105278
  12. Vilasboas-Campos, Daniela; Costa, Marta Daniela; Teixeira-Castro, Andreia; Rios, Rejaine; Silva, Fabiano Guimarães; Aierken, Aili; Zhang, Xiaoying; et al. "Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases (IF: 1.13)". Data in Brief 33 (2020): 106598. http://dx.doi.org/10.1016/j.dib.2020.106598.
    10.1016/j.dib.2020.106598
  13. Vilasboas-Campos, Daniela; Costa, Marta Daniela; Teixeira-Castro, Andreia; Rios, Rejaine; Silva, Fabiano Guimarães; Bessa, Carlos; Dias, Alberto C.P.; Maciel, Patrícia. "Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: Role of the glutathione redox cycle (IF:6.52)". Free Radical Biology and Medicine (2020): http://dx.doi.org/10.1016/j.freeradbiomed.2020.10.018.
    10.1016/j.freeradbiomed.2020.10.018
  14. Oliveira-Pinto, Sofia; Pontes, Olívia; Lopes, Diogo; Sampaio-Marques, Belém; Costa, Marta D.; Carvalho, Luísa; Gonçalves, Céline S.; et al. "Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment (IF: 5.04)". Bioorganic Chemistry 100 (2020): 103942. http://dx.doi.org/10.1016/j.bioorg.2020.103942.
    10.1016/j.bioorg.2020.103942
  15. Da Silva, Jorge Diogo; Oliveira, Stéphanie; Pereira-Sousa, Joana; Teixeira-Castro, Andreia; Costa, Marta Daniela; Maciel, Patrícia. "Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration (IF: 4.586)". Molecular Neurobiology (2019): http://dx.doi.org/10.1007/s12035-019-01833-0.
    Published • 10.1007/s12035-019-01833-0
  16. Pohl, Franziska; Teixeira-Castro, Andreia; Costa, Marta Daniela; Lindsay, Victoria; Fiúza-Fernandes, Juliana; Goua, Marie; Bermano, Giovanna; et al. "GST-4-Dependent Suppression of Neurodegeneration in C. elegans Models of Parkinson’s and Machado-Joseph Disease by Rapeseed Pomace Extract Supplementation (IF: 3.648)". Frontiers in Neuroscience 13 (2019): http://dx.doi.org/10.3389/fnins.2019.01091.
    Published • 10.3389/fnins.2019.01091
  17. Sahakyan, Hovhannes; Hooshiar Kashani, Baharak; Tamang, Rakesh; Kushniarevich, Alena; Francis, Amirtharaj; Costa, Marta D; Pathak, Ajai Kumar; et al. "Origin and spread of human mitochondrial DNA haplogroup U7 (IF: 5.228)". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/srep46044.
    Published • 10.1038/srep46044
  18. Pereira, Joana B.; Costa, Marta D.; Vieira, Daniel; Pala, Maria; Bamford, Lisa; Harich, Nourdin; Cherni, Lotfi; et al. "Reconciling evidence from ancient and contemporary genomes: a major source for the European Neolithic within Mediterranean Europe (IF: 4.847)". Proceedings of the Royal Society B: Biological Sciences 284 1851 (2017): 20161976. http://dx.doi.org/10.1098/rspb.2016.1976.
    Published • 10.1098/rspb.2016.1976
  19. Cavadas, Bruno; Soares, Pedro; Camacho, Rui; Brandão, Andreia; Costa, Marta D.; Fernandes, Verónica; Pereira, Joana B.; et al. "Fine Time Scaling of Purifying Selection on Human Nonsynonymous mtDNA Mutations Based on the Worldwide Population Tree and Mother-Child Pairs (IF: 5.089)". Human Mutation 36 11 (2015): 1100-1111. http://dx.doi.org/10.1002/humu.22849.
    Published • 10.1002/humu.22849
  20. Costa, Marta D.; Pereira, Joana B.; Pala, Maria; Fernandes, Verónica; Olivieri, Anna; Achilli, Alessandro; Perego, Ugo A.; et al. "A substantial prehistoric European ancestry amongst Ashkenazi maternal lineages (IF: 10.742)". Nature Communications 4 1 (2013): http://dx.doi.org/10.1038/ncomms3543.
    Published • 10.1038/ncomms3543
  21. Fernandes, Verónica; Alshamali, Farida; Alves, Marco; Costa, Marta D.; Pereira, Joana B.; Silva, Nuno M.; Cherni, Lotfi; et al. "The Arabian Cradle: Mitochondrial Relicts of the First Steps along the Southern Route out of Africa (IF: 11.202)". The American Journal of Human Genetics 90 2 (2012): 347-355. http://dx.doi.org/10.1016/j.ajhg.2011.12.010.
    Published • 10.1016/j.ajhg.2011.12.010
  22. Soares, P.; Alshamali, F.; Pereira, J. B.; Fernandes, V.; Silva, N. M.; Afonso, C.; Costa, M. D.; et al. "The Expansion of mtDNA Haplogroup L3 within and out of Africa (IF: 5.55)". Molecular Biology and Evolution 29 3 (2011): 915-927. http://dx.doi.org/10.1093/molbev/msr245.
    Published • 10.1093/molbev/msr245
  23. Aguiar-Pinto Mina I; Costa M; Matos A; Sousa Coutinho Calheiros C; Castro PM. "Polishing domestic wastewater on a subsurface flow constructed wetland: organic matter removal and microbial monitoring (IF: 2.085)". International Journal of Phytoremediation 13 (2011): 947-958. http://europepmc.org/abstract/med/21972563.
    Published • 10.1080/15226514.2010.532182
  24. Pereira, Luísa; Silva, Nuno M; Franco-Duarte, Ricardo; Fernandes, Verónica; Pereira, Joana B; Costa, Marta D; Martins, Haidé; et al. "Population expansion in the North African Late Pleistocene signalled by mitochondrial DNA haplogroup U6 (IF: 3.702)". BMC Evolutionary Biology 10 1 (2010): 390. http://dx.doi.org/10.1186/1471-2148-10-390.
    Published • 10.1186/1471-2148-10-390
  25. Harich, Nourdin; Costa, Marta D; Fernandes, Verónica; Kandil, Mostafa; Pereira, Joana B; Silva, Nuno M; Pereira, Luísa. "The trans-Saharan slave trade - clues from interpolation analyses and high-resolution characterization of mitochondrial DNA lineages (IF: 3.702)". BMC Evolutionary Biology 10 1 (2010): 138. http://dx.doi.org/10.1186/1471-2148-10-138.
    Published • 10.1186/1471-2148-10-138
  26. Cherni, Lotfi; Fernandes, Verónica; Pereira, Joana B.; Costa, Marta D.; Goios, Ana; Frigi, Sabeh; Yacoubi-Loueslati, Besma; et al. "Post-last glacial maximum expansion from Iberia to North Africa revealed by fine characterization of mtDNA H haplogroup in Tunisia (IF: 2.756)". American Journal of Physical Anthropology 139 2 (2009): 253-260. http://dx.doi.org/10.1002/ajpa.20979.
    Published • 10.1002/ajpa.20979
  27. Pereira, Luísa; Freitas, Fernando; Fernandes, Verónica; Pereira, Joana B.; Costa, Marta D.; Costa, Stephanie; Máximo, Valdemar; et al. "The Diversity Present in 5140 Human Mitochondrial Genomes (IF: 12.303)". The American Journal of Human Genetics 84 5 (2009): 628-640. http://dx.doi.org/10.1016/j.ajhg.2009.04.013.
    Published • 10.1016/j.ajhg.2009.04.013
  28. Costa, Marta D.; Cherni, Lotfi; Fernandes, Verónica; Freitas, Fernando; Ammar el Gaaied, Amel Ben; Pereira, Luísa. "Data from complete mtDNA sequencing of Tunisian centenarians: Testing haplogroup association and the “golden mean” to longevity (IF: 4.179)". Mechanisms of Ageing and Development 130 4 (2009): 222-226. http://dx.doi.org/10.1016/j.mad.2008.12.001.
    Published • 10.1016/j.mad.2008.12.001
  29. Cerný, Viktor; Fernandes, Verónica; Costa, Marta D; Hájek, Martin; Mulligan, Connie J; Pereira, Luísa. "Migration of Chadic speaking pastoralists within Africa based on population structure of Chad Basin and phylogeography of mitochondrial L3f haplogroup (IF:4.294)". BMC Evolutionary Biology 9 1 (2009): 63. http://dx.doi.org/10.1186/1471-2148-9-63.
    Published • 10.1186/1471-2148-9-63
Thesis / Dissertation
  1. Costa, Marta Daniela. "Genetic characterisation of the Early Upper Palaeolithic settlement of Europe by modern humans". PhD, University of Leeds Faculty of Biological Sciences, 2013.
  2. Costa, Marta Daniela. "Microbiological characterization of the wastewater Phragmites australis rizhospere in a constructed wetland from the north of Portugal.". Master, Universidade do Minho Escola de Ciências, 2008.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/03/03 Anti-aging genetic mutations impact diferentially in Machado-Joseph disease SPDMov (Portuguese Society of Movement Disorder) – Genetics of Movement Disorders
Portuguese Society of Movement Disorder (Curia, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - Current Neuroprotective activities of macroalgae extracts and phytochemicals
Co-supervisor
 Master Degree (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024/07/01 - 2024/10/31 Caenorhabditis elegans as a model to study gene function – identification of genetic modifiers in a C. elegans model of Machado-Joseph disease (MJD)
Supervisor
 Medicine (Master)
Universidade do Minho Escola de Medicina, Portugal
2022/05/01 - 2022/10/31 Evaluation of neuroprotective capacity of macroalgae extracts, in Saccharomyces cerevisiae and Caenorhabditis elegans models.
Supervisor
Universidade do Minho, Portugal
2021/05/03 - 2021/06/14 Anti-aging mutations in the C. elegans model of Machado-Joseph Disease (MJD).
Supervisor of João Belmiro Baptista Martins
 Medicina (Scientific initiation)
Universidade do Minho Escola de Medicina, Portugal
2021/05/03 - 2021/06/11 Motor phenotype of a C. elegans proteostasis sensor strain: Optimization steps for a future drug screening.
Supervisor of Joana Maria Marques Lopes
 Medicina (Scientific initiation)
Universidade do Minho Escola de Medicina, Portugal
2020/10/01 - 2021/03/31 Estudo do efeito terapêutico de compostos com ligandos multi-alvo num modelo C. elegans de tauopatia.
Co-supervisor
 Bioquimica, UTAD, Portugal (Scientific initiation)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/10/01 - 2021/03/31 Estudo dos efeitos terapêuticos de derivados de piridinas e cromenos em modelos C. elegans de doenças neurodegenerativas
Co-supervisor
 Bioquimica, UTAD, Portugal (Scientific initiation)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/05/01 - 2019/12/20 Linking autophagy to feeding status: the function of egli-1 in the Caenorhabditis elegans nervous system
Supervisor of Jorge Diogo Cruz Ramos da Silva
 Mestrado Integrado em Medicina (Projecto de Opção- Estágio Final) (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/05 - 2017/05 XV Meeting Portuguese Society of Neurosciences - member of staff (2017/05 - 2017/05)
Congress (Other)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2013 - Current Event participation: Neurosciencies scientific retreat - ICVS
Meeting
2023/09/29 - 2023/09/29 "Noite Europeia dos Investigadores"
Exhibition
 "Noite Europeia dos Investigadores"
Universidade do Minho, Portugal
2023/03/13 - 2023/03/17 "International Brain Awareness week"
Workshop
 "International Brain Awareness week"
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/06/21 - 2021/06/24 Event participation: 23rd International C. elegans Conference
Conference
 23rd International C. elegans Conference - online
Genetics Society of America, United States
2021/05/24 - 2021/05/27 Event Participation: Ataxia Investigators Meeting Ataxia Investigators Meeting (AIM2021 - online)
National Ataxia Foundation, United States
2020/09/30 - 2020/09/30 Online course: Misfolding of a-synuclein and tau protein: from basic mechanisms to therapeutic development
International Parkinson and Movement Disorder Society, United States
2020/09/12 - 2020/09/16 MDS Virtual Congress
International Parkinson and Movement Disorder Society, United States
2019/03 - 2019/03 Workshop: Strategies and tools for modulating pathologic protein self-assembly in proteinopathies
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - 2019 Advanced course: "Systematic Review and Meta-Analysis"
Universidade do Minho Escola de Medicina, Portugal
2018/03 - 2018/03 Event participation: SPDmov 2018 congress
Congress
2017/11 - 2017/11 Event participation: 11st Meeting of the Portuguese Society of Human Genetics.
Congress
2017/05 - 2017/05 Event participation: Portuguese Society of Neurosciences (SPN) congress
Congress
2016 - 2016 Event participation: Congress of the Portuguese Biochemical Society
Congress
2015/06 - 2015/06 Advanced course: High content screening and image analysis for biosciences
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2015/04 - 2015/04 Advanced course: Pathogenesis of neurodegenerative diseases
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/02 - 2014/02 Advanced course: A hands-on approach to cell and tissue culture
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014 - 2014 Event participation: Congress of the Portuguese Biochemical Society
Congress
2013/07 - 2013/07 Advanved course: C. elegans course
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2013 Event participation: I3S scientific retreat
Meeting
2012/06 - 2012/06 Event participation: SMBE 2012
Congress
2012 - 2012 Practical course: Genotyping techniques of Y-chromosome - University of Oxford
Workshop
2010/05 - 2010/05 Event participation: XXXV Portuguese Genetics Conference
Congress
2010 - 2010 Workshop: Working effectively with your supervisor
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Excel 2007 for Research 'Analysing & Manipulating Data
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Speed reading
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Finding PhD thesis
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Being a Post-Doc Abroad
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Overview of Graphics and mapping Software
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Time management
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: A Balancing Act: dealing with the stress of doing a research degree
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Pathways to Impact
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: RRS and publication alerts for research
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: SDDU Marking Training
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Writing workshop
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Researcher@Leeds
Workshop
University of Leeds, United Kingdom
2010 - 2010 Workshop: Adope Photoshop
Workshop
University of Leeds, United Kingdom
2009 - 2009 Workshop: The Transfer Viva
Workshop
University of Leeds, United Kingdom
2009 - 2009 Workshop: Creative thinking techniques
Workshop
University of Leeds, United Kingdom
2009 - 2009 Workshop: How to get your paper written and published
Workshop
University of Leeds, United Kingdom
2007/11 - 2007/11 Event participation: Link-age Meeting
Congress
2006 - 2006 Event participation: "Dia do Jovem Investigador"
Conference
 Dia do Jovem Investigador
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12/21 Doctoral Examinations in Health Sciences. Thesis title: Assessing the therapeutic role of the secretome from mesenchymal stromal cells in genetic models of Parkinson's Disease based on the overexpression of alpha-synuclein
Thesis Member
 Claúdia Raquel Ferreira Marques (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/10/14 - 2024/10/14 Fundamentals in Oncobiology (Pós-Graduação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/09/22 - 2024/01/29 Course: Fundamentals in Neurosciences (2018 edition)- "Motor behavior in C. elegans" Fundamentals in Neuroscience (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009/09 - 2010/02 Practical lectures: Human population genetics and evolution Human population genetics and evolution University of Leeds Faculty of Biological Sciences, United Kingdom
2009/09 - 2010/02 Practical lectures: Molecular evolution; level 2 University of Leeds Faculty of Biological Sciences, United Kingdom

Mentoring / Tutoring

Topic Student name
2019 - Current Tutor of the laboratorial work of Jorge Fernandes Jorge Fernandes
2021/09/15 - 2021/11/30 Tutor of the laboratorial work of Laura Blaikie (Erasmus program) - Student from Dr. Paul Kong lab. Laura Blaikie
2019/03 - 2019/07 Tutor of the laboratorial work of Laura Blaikie (Erasmus program) - Student from Dr. Paul Kong lab. Laura Blaikie
2017 - 2019 Tutor of the laboratorial work of the Phd Student Jorge Diogo da Silva, from the Medicine PhD program. Jorge Diogo Cruz Ramos da Silva
2018/04 - 2018/07 Tutor of the laboratorial work of Victoria Lindsay (Erasmus program) - student from Dr. Paul Kong lab Victoria Linday
2018 - 2018 Tutor of the laboratorial work of Maira Fonseca in the project “Phytochemistry analysis and bioactivities evaluation applied to medicinal plants and functional food”, from the company EPAMIG: Empresa de Pesquisa Agropecuária de Minas Gerais – Brasil Maira Fonseca
2017 - 2018 Tutor of the master student Daniela Campos, from the master program “Molecular Biology, Biotechnology and Bioentrepreneurship in Plants” (School of Sciences, University of Minho) Daniela Campos
2013 - 2013 Tutor in a laboratorial rotation of the Phd student Teresa Rodrigues, from the PhD program PHDOC Teresa Rodrigues
Distinctions

Award

2023 Brain Living Lab - RESOLVE-Health 2.0 Acceleration Program
2020 National Ataxia Foundation travel stipend award to attend conference in Denver
2019 Seed-Money Grant from National Ataxia Foundation
National Ataxia Foundation, United States
2018 Portuguese Society of Movement Disorders - award to attend SPDmov 2018
2012 Best poster presentation in the III I3S retreat
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2001 Honor board of excellent students
Externato Infante D. Henrique/Alfacoop, Portugal