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Identification

Personal identification

Full name
Deborah Penque
Gender
Female

Citation names

  • Penque, Deborah

Author identifiers

Ciência ID
8516-64E0-A47E
ORCID iD
0000-0002-4527-7148

Email addresses

  • deborah.penque@insa.min-saude.pt (Professional)

Addresses

  • INSARJ. Departamento de Genética, Instituto Nacional de Saúde Dr Ricardo Jorge, 1649-016, Lisboa, Lisboa, Portugal (Professional)
Education
Degree Classification
1993
Concluded
 PHD in Biology (Genetics) (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Contribuition to the study of microtubules in Tetrahymena pyriformis" (THESIS/DISSERTATION)
 louvor e distinção
1985
Concluded
 BSc in Biology (Molecular Biology) (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Contribution to the Study of Microtubule Proteins of Tetrahymena pyriformis " (THESIS/DISSERTATION)
 16/20
Affiliation

Positions / Appointments

Category
Host institution 		Employer
2015 - Current Proteomics & Genomics Unit Coordinator Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
1996/01/01 - Current Proteomics Laboratory - Research Group Leader Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Outputs

Publications

Book chapter
  1. Ventura C; Torres V; Vieira L; Gomes B; Rodrigues AS; Jose Rueff; Penque D; Silva, Maria Joao. "New "Omics" Approaches as Tools to Explore Mechanistic Nanotoxicology.". 2022.
    10.1007/978-3-030-88071-2_8
  2. Torres, Vukosava Milic; Popovic, Lazar; Vaz, Fatima; Penque, Deborah; Torres, V.M.; Popovic, L.; Vaz, F.; Penque, D.. "Proteomics in the assessment of the therapeutic response of antineoplastic drugs: strategies and practical applications". 2016.
    10.1007/978-1-4939-3347-1_16
  3. Gomes-Alves, Patricia; Neves, Sofia; Penque, Deborah. "Signaling Pathways of Proteostasis Network Unraveled by Proteomic Approaches on the Understanding of Misfolded Protein Rescue". Elsevier, 2011.
    doi: 10.1016/B978-0-12-385928-0.00013-4
Conference paper
  1. Penque, Deborah. "EuPA News from the EuPA Conference and Communication Committee (CCC)". 2016.
    doi.org/10.1016/j.euprot.2016.03.006
  2. Silva, M.J.; Vital, Nádia; Pacheco, Solange; Antunes, Susana; Neves, Sofia; Louro, Henriqueta; Torre, Vukosava M.; et al. "Occupational exposure to environmental tobacco smoke in hospitality venues: are genetic- or proteomics-based biomarkers predictive of respiratory diseases?". 2016.
  3. Penque, Deborah. "O Laboratório de Proteómica do Instituto Ricardo Jorge". 2015.
  4. Feliciano, Amelia; Bozanic, Vesna; Torres, Vukosava Milic; Matthiesen, Rune; Carvalho, Ana S.; Almeida, Andreia; Alexandre, Bruno; et al. "Proteomics of Red Blood Cells from Patients with Obstructive Sleep Apnea". 2015.
  5. Vaz, Fátima; Feliciano, Amélia; Silva, Ana Rita; Coelho, Cristina; Torres, Vukosava Millic; Bozanic, Vesna; Malhotra, Atul; et al. "Obstructive Sleep Apnea: New insights into antioxidant activity and cellular response to stress". 2015.
  6. Vital, Nádia; Louro, Henriqueta; Antunes, Susana; Penque, Deborah; Simões, Tânia; Silva, Maria João. "Biomonitoring the genetic effects of environmental tobacco smoke exposure in restaurant workers". 2013.
  7. Vaz, Fátima; Charro, Nuno; Morais, Anabela; Lavinha, João; Penque, Deborah. "2-DIGE of Red Blood Cells from Sickle-Cell Disease Patients with Severe Vaso-Occlusion.". 2013.
  8. Lavinha, João; Charro, Nuno; Vaz, Fátima; Morais, Anabela; Penque, Deborah. "Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics". 2012.
  9. Pacheco, Solange; Simoes, Tania; Torres, Vukosawa; Lopes, Carlos; Almeida, Bugalho; Penque, Deborah. "Disclosing effects of tobacco smoke on occupationally exposed workers at Lisbon restaurants". 2012.
  10. Simões, Tânia; Milic, Vukosava D.; Pacheco, S.A.; Aguiar, Fátima; Gomes, Filomena; Louro, Henriqueta; Vital, Nádia; et al. "Tobacco Smoke Occupational Exposure: Biomarkers of Biological Damage". 2011.
  11. Peneda, Jorge; Charro, Nuno; L. Hood, Brian; Fonseca, Aidil; Hagenfeldt, Manuela; Miranda, Armandina; Zerimech, Farid; et al. "Utilidade da Proteómica na Compreensão da Patogenia Molecular Proximal da Doença Cerebral Alcoólica". 2011.
  12. Louro, Henriqueta; Carmo, Susana; Vital, Nádia; Gomes, Filomena; Penque, Deborah; Simões, Tânia; Silva, Maria João. "Exposure to second-hand smoke in occupational settings: biomarkers of DNA damage and susceptibility". 2011.
    doi: 10.1093/mutage/ger026
  13. Vital, Nádia; Antunes, Susana; Louro, Henriqueta; Penque, Deborah; Simões, Tânia; Silva, Maria João. "Fumo de Tabaco em Estabelecimentos Recreativos: Biomarcadores de Genotoxicidade e Susceptibilidade Genética". 2011.
  14. Antunes, Susana; Vital, Nadia; Louro, Henriqueta; Gomes, Filomena; Penque, Deborah; Simões, Tânia; Silva, Maria João. "Exposição ao Fumo Passivo no Local de Trabalho: Biomarcadores de Genotoxicidade e Susceptibilidade". 2011.
  15. Simões, Tânia; Torres, Vukosava; Pacheco, Solange; Louro, Henriqueta; Silva, Maria Joao; Charro, Nuno; Alexandre, Bruno; Vaz, Fatima; Penque, Deborah. "Tobacco smoke occupational exposure: biomarkers of biological damage". 2011.
Journal article
  1. Febra C; Spinu V; Ferreira F; Gil V; Maio R; Penque D; Ana Macedo. "Predictive Value for Increased Red Blood Cell Distribution Width in Unprovoked Acute Venous Thromboembolism at the Emergency Department.". Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (2023): https://europepmc.org/articles/PMC10494517.
    10.1177/10760296231193397
  2. Vital, Nádia; Antunes, Susana; Louro, Henriqueta; Vaz, Fátima; Simões, Tânia; Penque, Deborah; Silva, Maria João. "Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars". Frontiers in Public Health 9 (2021): http://dx.doi.org/10.3389/fpubh.2021.674142.
    Open access • Published • 10.3389/fpubh.2021.674142
  3. Miranda, H.V.; Szego, ÉM.; Oliveira, L.M.A.; Breda, C.; Darendelioglu, E.; de Oliveira, R.M.; Ferreira, D.G.; et al. "Erratum to: Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". Brain : a journal of neurology 144 6 (2021): e58-e58. http://www.scopus.com/inward/record.url?eid=2-s2.0-85112862951&partnerID=MN8TOARS.
    10.1093/brain/awab175
  4. Cristina Valentim-Coelho; Fátima Vaz; Marília Antunes; Sofia Neves; Inês L. Martins; Hugo Osório; Amélia Feliciano; et al. "Redox - Oligomeric State of Peroxiredoxin-2 and Glyceraldehyde-3-Phosphate Dehydrogenase in Obstructive Sleep Apnea Red Blood Cells under Positive Airway Pressure Therapy". Antioxidants 9 12 (2020): 1184-1184. https://doi.org/10.3390/antiox9121184.
    10.3390/antiox9121184
  5. Van Gool, Alain; Corrales, Fernado; Colovic, Mirjana; Krstic, Danijela; Oliver-Martos, Begona; Martínez-Cáceres, Eva; Jakasa, Ivone; et al. "Analytical techniques for multiplex analysis of protein biomarkers". Expert Review of Proteomics 17 4 (2020): 257-273. http://dx.doi.org/10.1080/14789450.2020.1763174.
    10.1080/14789450.2020.1763174
  6. Eda Aydindogan; Deborah Penque; Jerome Zoidakis. "Systematic review on recent potential biomarkers of chronic obstructive pulmonary disease". Expert Review of Molecular Diagnostics (2019): 1-9. https://doi.org/10.1080/14737159.2018.1559054.
    10.1080/14737159.2018.1559054
  7. Penque, Deborah. "Editorial: Breakthroughs in top-down proteomics.". Journal of proteomics (2018): https://doi.org/10.1016/j.jprot.2017.12.011.
    10.1016/j.jprot.2017.12.011
  8. Penque, Deborah. "Editorial: Tutorials in Bioinformatics for Biological Science.". Journal of proteomics (2018): https://doi.org/10.1016/j.jprot.2017.11.011.
    10.1016/j.jprot.2017.11.011
  9. Penque, Deborah. "Effects of positive airway pressure therapy on cardiovascular and metabolic markers in males with obstructive sleep apnea.". Revista portuguesa de pneumologia (2017): https://doi.org/10.1016/j.rppnen.2017.02.010.
    10.1016/j.rppnen.2017.02.010
  10. Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. "Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". Brain 140 5 (2017): 1399-1419. http://dx.doi.org/10.1093/brain/awx056.
    10.1093/brain/awx056
  11. de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. "Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". PLOS Biology 15 4 (2017): e1002601. http://dx.doi.org/10.1371/journal.pbio.1002601.
    10.1371/journal.pbio.1002601
  12. de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. "The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". PLOS Biology 15 3 (2017): e2000374. http://dx.doi.org/10.1371/journal.pbio.2000374.
    10.1371/journal.pbio.2000374
  13. Feliciano, A.; Linhas, R.; Marçôa, R.; Cysneiros, A.; Martinho, C.; Reis, R.P.; Penque, D.; Pinto, P.; Bárbara, C.. "Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure". Revista Portuguesa de Pneumologia (English Edition) 23 2 (2017): 71-78. http://dx.doi.org/10.1016/j.rppnen.2016.12.001.
    10.1016/j.rppnen.2016.12.001
  14. Feliciano, Amélia; Vaz, Fátima; Torres, Vukosava M; Valentim-Coelho, Cristina; Silva, Rita; Prosinecki, Vesna; Alexandre, Bruno M; et al. "Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells: Correlation with polysomnographic and metabolic parameters". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863 2 (2017): 621-629. http://dx.doi.org/10.1016/j.bbadis.2016.11.019.
    10.1016/j.bbadis.2016.11.019
  15. Feliciano, A.; Vaz, F.; Valentim-Coelho, C.; Torres, V.M.; Silva, R.; Prosinecki, V.; Alexandre, B.M.; et al. "Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome". Data in Brief 11 (2017): 103-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010211043&partnerID=MN8TOARS.
    10.1016/j.dib.2017.01.005
  16. Feliciano, Amélia; Torres, Vukosava Milic; Vaz, Fátima; Carvalho, Ana Sofia; Matthiesen, Rune; Pinto, Paula; Malhotra, Atul; Bárbara, Cristina; Penque, Deborah. "Overview of proteomics studies in obstructive sleep apnea". Sleep Medicine 16 4 (2015): 437-445. http://dx.doi.org/10.1016/j.sleep.2014.11.014.
    10.1016/j.sleep.2014.11.014
  17. Carvalho, Ana Sofia; Penque, Deborah; Matthiesen, Rune. "Bottom up proteomics data analysis strategies to explore protein modifications and genomic variants". PROTEOMICS 15 11 (2015): 1789-1792. http://dx.doi.org/10.1002/pmic.201400186.
    10.1002/pmic.201400186
  18. Carvalho, A.S.; Ribeiro, H.; Voabil, P.; Penque, D.; Jensen, O.N.; Molina, H.; Matthiesen, R.. "Global mass spectrometry and transcriptomics array based drug profiling provides novel insight into glucosamine induced endoplasmic reticulum stress". Molecular and Cellular Proteomics 13 12 (2014): 3294-3307. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924284221&partnerID=MN8TOARS.
    10.1074/mcp.M113.034363
  19. Miranda, H.V.; Xiang, W.; De Oliveira, R.M.; Simões, T.; Pimentel, J.; Klucken, J.; Penque, D.; Outeiro, T.F.. "Heat-mediated enrichment of a-synuclein from cells and tissue for assessing post-translational modifications". Journal of Neurochemistry 126 5 (2013): 673-684. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883177285&partnerID=MN8TOARS.
    10.1111/jnc.12251
  20. Sebastiana, M.; Figueiredo, A.; Monteiro, F.; Martins, J.; Franco, C.; Coelho, A.V.; Vaz, F.; et al. "A possible approach for gel-based proteomic studies in recalcitrant woody plants". SpringerPlus 2 1 (2013): 1-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878793462&partnerID=MN8TOARS.
    10.1186/2193-1801-2-210
  21. O'Neil, S. E.; Palviainen, M. J.; Ten Have, S.; Filiou, M.; Gonzalez, A.; Hodge, K.; Surinova, S.; Penque, D.; Baker, M. S.. "Clinical proteomics stretch goals: EuPA 2012 roundtable report". Journal of Proteomics 88 (2013): 37-40.
    10.1016/j.jprot.2013.04.012
  22. Smith, Lloyd M.; Kelleher, Neil L.; Consortium Top Down Proteomics. "Proteoform: a single term describing protein complexity". Nature Methods 10 3 (2013): 186-187.
    10.1038/nmeth.2369
  23. Pacheco, Solange A.; Torres, Vukosava M.; Louro, Henriqueta; Gomes, Filomena; Lopes, Carlos; Marcal, Nelson; Fragoso, Elsa; et al. "Effects of Occupational Exposure to Tobacco Smoke: Is There a Link Between Environmental Exposure and Disease?". Journal of Toxicology and Environmental Health-Part a-Current Issues 76 4-5 (2013): 311-327.
    10.1080/15287394.2013.757269
  24. Alexandre, B.M.; Charro, N.; Blonder, J.; Lopes, C.; Azevedo, P.; Bugalho de Almeida, A.; Chan, K.C.; et al. "Profiling the erythrocyte membrane proteome isolated from patients diagnosed with chronic obstructive pulmonary disease". Journal of Proteomics 76 (2012): 259-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869863889&partnerID=MN8TOARS.
    10.1016/j.jprot.2012.04.008
  25. Pacheco, S.A.; Aguiar, F.; Ruivo, P.; Proença, M.C.; Sekera, M.; Penque, D.; Simões, T.. "Occupational exposure to environmental tobacco smoke: A study in Lisbon restaurants". Journal of Toxicology and Environmental Health - Part A: Current Issues 75 13-15 (2012): 857-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864072018&partnerID=MN8TOARS.
    10.1080/15287394.2012.690690
  26. Pedroso, N.; Gomes-Alves, P.; Marinho, H.S; Brito, V.B.; Boada, C.; Antunes, F.; Herrero, E.; Penque, D.; Cyrne, L.. "The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae". Free Radical Research 46 10 (2012): 1267-1279. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866309006&partnerID=MN8TOARS.
    10.3109/10715762.2012.704997
  27. Penque, Deborah. "Chronic Obstruct0ive Pulmonary Disease and Proteomics: A Match for Success?". Allergy and Therapy- -OMICS Group (2012):
  28. Penque, Deborah. "Proteomics in Detection and Monitoring Chronic Lung Diseases: The Human Nasal Epithelium as a Molecular Model". Journal of Allergy and Therapy-OMICS Group, S7:004. (2012):
Report
  1. Penque, Deborah; Vieira, Luis; Gonçalves, João; Louro, Henriqueta; Silva, Maria João. 2016. Annual Scientific Report of the Center for Toxicogenomics and Human Health. http://hdl.handle.net/10400.18/4614.
Thesis / Dissertation
  1. Feliciano, Amélia. "Apneia obstrutiva do sono : marcadores de gravidade e de resposta à terapêutica". PhD, 2017. http://hdl.handle.net/10362/26594.
  2. Pacheco, Solange Almeida, 1984-. "Translating proteomics into environmental health : biomarkers discovery for tobacco smoke-induced biological damage". PhD, 2015. http://hdl.handle.net/10451/22540.
  3. Coelho, Cristina Valentim. "Validação de potenciais biomarcadores proteómicos na Síndrome da Apneia Obstrutiva do Sono". Master, 2015. http://hdl.handle.net/10451/22497.
  4. Silva, Ana Rita dos Reis; Silva, Ana Rita. "Proteómica da Apneia Obstrutiva do Sono para a descoberta de biomarcadores". Master, 2015. http://hdl.handle.net/10451/22561.
  5. Charro, Nuno Miguel Antunes Garcia, 1983-. "Towards the identification of biomarkers for cystic fibrosis by proteomics". PhD, 2011. http://hdl.handle.net/10451/4305.
  6. Alexandre, Bruno Miguel Coelho, 1980-. "Chronic obstructive pulmonary disease : a proteomics approach". PhD, 2011. http://hdl.handle.net/10451/4969.
  7. Neves, Sofia Maria Sentieiro. "Perfil de expressão dos microRNAs, miR-122 e miR-22, em doentes com hepatite crónica C". Master, 2010. http://hdl.handle.net/10451/2391.
  8. Santos, José Daniel da Costa Rodrigues. "Gestão e análise de dados biomédicos". Master, 2008. http://hdl.handle.net/10451/15243.
  9. Oliveira, Isabel Carvalho, 1978-. "Identification of differentially expressed proteins in cystic fibrosis by proteomics". PhD, 2008. http://sibul.reitoria.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000543924.

Other

Other output
  1. Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure. Obstructive sleep apnea syndrome (OSAS) is a systemic inflammatory disease associated with cardiovascular consequences. Red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) are recognized biomarkers of cardiovascular morbidity/mortality. Limited data is available on the association between these parameters and OSAS severity and the relationship. 2017. Feliciano, Amelia; Linhas, R.; Marçõa, R.; Cysneiros, A.; Martinho, C.; Reis, R.P.; Penque, Deborah; Pinto, P.; Bárbara, Cristina. http://hdl.handle.net/10400.18/4920.
    10.1016/j.rppnen.2016.12.001
  2. Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells : correlation with polysomnographic and metabolic parameters. We have examined the effects of Obstructive Sleep Apnea (OSA) on red blood cell (RBC) proteome variation at evening/morning day time to uncover new insights into OSA-induced RBC dysfunction that may lead to OSA manifestations. Dysregulated proteins mainly fall in the group of catalytic enzymes, stress response and redox regulators such as peroxiredoxin 2 (PRDX2). Validation assays confirmed that a. 2017. Feliciano, Amélia; Vaz, Fátima; Torres, Vukosava M.; Coelho, Cristina Valentim; Silva, Rita; Prosinecki, Vesna; Alexandre, Bruno M.; et al. http://hdl.handle.net/10451/27393.
    10.1016/j.bbadis.2016.11.019
  3. Second-hand smoke exposure effects on nasal epithelia proteome. Environmental second-hand smoke exposure (SHS) results in a statistically significant increase in the risk of diseases such cardiovascular diseases and lung cancer. Cigarette smoke contains thousands of constituents, including several carcinogens and cytotoxic chemicals that orchestrate chronic inflammatory responses and destructive remodeling events1,2. In this work, our main objective is to unco. 2017. Neves, Sofia; Pacheco, Solange; Vaz, Fatima; James, Peter; Penque, Deborah. http://hdl.handle.net/10400.18/5520.
  4. Tutorials in Bioinformatics for Biological Science [editorial]. One of the major challenges of the past few years is the integration of Omics data to disclose its biological meaning. With the advances in Omics technologies the complexity and amount of retrieved data has increased, making difficult and time-consuming its integrative analysis. Even so, the integration of a wide spectrum of Omics data sets is essential to promote translational research. Bioinform. 2017. Vitorino, R.; Carvalho, P.; Penque, Deborah. http://hdl.handle.net/10400.18/5701.
    J Proteomics. 2018 Jan 16;171:1. doi:10.1016/j.jprot.2017.11.011. Epub 2017 Dec 5.
  5. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin. 2017. de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. http://hdl.handle.net/10400.18/5465.
    PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar.
  6. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. 2017. Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M.A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. http://hdl.handle.net/10400.18/5439.
    Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.
  7. Overview of proteomics studies in obstructive sleep apnea. Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have bec. 2015. Feliciano, Amélia; Torres, Vukosava M.; Vaz, Fatima; Carvalho, Ana Sofia; Matthiesen, Rune; Pinto, Paula; Malhotra, Atul; Bárbara, Cristina; Penque, Deborah. http://hdl.handle.net/10400.18/3093.
    Sleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb 14
  8. Bottom up proteomics data analysis strategies to explore protein modifications and genomic variant. The quest to understand biological systems requires further attention of the scientific community to the challenges faced in proteomics. In fact the complexity of the proteome reaches uncountable orders of magnitudes. This means that significant technical and data-analytic innovations will be needed for the full understanding of biology. Current state of art mass spectrometry (MS) is probably our. 2015. Carvalho, Ana; Matthiesen, Rune; Penque, Deborah. http://hdl.handle.net/10400.18/3458.
    Proteomics. 2015 Jun;15(11):1789-92. doi: 10.1002/pmic.201400186. Epub 2015 Mar 30.
  9. Second-hand tobacco smoke effects evaluated by proteomics. Second-hand smoke (SHS) is responsible for more then 600000 premature year deaths. In the European Union, 14% of Non-Smokers (NS) are exposed to other individuals’ tobacco smoke at home and 30% are exposed at the workplace. Towards their protection several European countries, except Portugal, move to a total tobacco ban in indoor public places. In 2008, a project aiming to analyze the impact of pa. 2015. Pacheco, Solange; Vaz, Fatima; penque, deborah; Neves, Sofia; Torres, Vukosava. http://hdl.handle.net/10400.18/3563.
  10. Proteomics in biomarker discovery for clinical purposes. Clinical Proteomics Dedicated to the study of the PROTEOME PROFILE associated with the HEALTHY AND DISEASE STATE, in the search for DIAGNOSTIC / PROGNOSTIC / MONITORING BIOMARKERS or as TARGETS for the development of new therapeutic approaches. 2015. Penque, Deborah. http://hdl.handle.net/10400.18/3564.
  11. A possible approach for gel-based proteomic studies in recalcitrant woody plants. Woody plants are particularly difficult to investigate due to high phenolic, resin, and tannin contents and laborious sample preparation. In particular, protein isolation from woody plants for two-dimensional gel electrophoresis (2-DE) is challenging as secondary metabolites negatively interfere with protein extraction and separation. In this study, three protein extraction protocols, using TCA, p. 2013. Sebastiana, Mónica; Figueiredo, Andreia; Monteiro, Filipa; Martins, Joana; Franco, Catarina; Coelho, Ana Varela; Vaz, Fátima; et al. http://hdl.handle.net/10400.18/1730.
    Springerplus. 2013 May 8;2(1):210. Print 2013 Dec.
  12. Heat-mediated enrichment of a-synuclein from cells and tissue for assessing post-translational modifications. a-synuclein (a-syn) is the major component of Lewy bodies, a pathological hallmark of Parkinson's disease and other synucleinopathies. The characterization of a-syn post-translational modifications (PTMs), thought to interfere with its aggregation propensity and cellular signaling, has been limited by the availability of extraction methods of endogenous protein from cells and tissues, and by the a. 2013. Vicente Miranda, Hugo; Xiang, Wei; Oliveira, Rita M. de; Simões, Tânia; Pimentel, José; Klucken, Jochen; Penque, Deborah; Outeiro, Tiago. http://hdl.handle.net/10400.18/1729.
    doi: 10.1111/jnc.12251
  13. Effects of occupational exposure to tobacco smoke: is there a link between environmental exposure and disease?. In a previous study, evidence was provided that indoor secondhand tobacco smoke (SHS) air pollution remains high in Lisbon restaurants where smoking is allowed, regardless of the protective measures used. The aim of this study was to determine in these locations the levels of polycyclic aromatic hydrocarbons (PAH) associated with the particulate phase of SHS (PPAH), a fraction that contains recogn. 2013. Pacheco, Solange A.; Torres, Vukosava M.; Louro, Henriqueta; Gomes, Filomena; Lopes, Carlos; Marçal, Nelson; Fragoso, Elsa; et al. http://hdl.handle.net/10400.18/1735.
    J Toxicol Environ Health A. 2013;76(4-5):311-27. doi: 10.1080/15287394.2013.757269
  14. Exposição ocupacional ao fumo de tabaco: alterações subclínicas em proteínas de inflamação aguda. 2013. Pacheco, Solange; Simões, Tânia; Penque, Deborah. http://hdl.handle.net/10400.18/2114.
  15. Clinical proteomics stretch goals: EuPA 2012 roundtable report. The field of clinical proteomics is faced with multiple challenges which need to be overcome in order to improve our understanding of human diseases and provide management solutions. Researchers interested in clinical proteomics assembled for a roundtable discussion at the European Association for Proteomics (EuPA) conference held in Glasgow in July 2012, to discuss these challenges and highlight. 2013. O'Neil, S.E.; Palviainen, M.J.; Ten Have, S.; Penque, Deborah; Baker, M.S.. http://hdl.handle.net/10400.18/2137.
    J Proteomics. 2013 Aug 2;88:37-40. doi: 10.1016/j.jprot.2013.04.012. Epub 2013 Apr 16
  16. Exposição ocupacional ao fumo de tabaco ambiental: um estudo em restaurantes na cidade de Lisboa. 2012. Pacheco, Solange; Aguiar, Fátima; Proença, Carmo; Penque, Deborah; Simões, Tânia. http://hdl.handle.net/10400.18/1401.
  17. Occupational Exposure to Environmental Tobacco Smoke: A Study in Lisbon Restaurants. Environmental tobacco smoke (ETS), also referred to as secondhand smoke (SHS), is a major threat to public health and is increasingly recognized as an occupational hazard to workers in the hospitality industry. Therefore, several countries have implemented smoke-free regulations at hospitality industry sites. In Portugal, since 2008, legislation partially banned smoking in restaurants and bars but. 2012. Pacheco, Solange; Aguiar, Fátima; Proença, Maria do Carmo; Penque, Deborah; Ruivo, Patricia; Simoes, Tania. http://hdl.handle.net/10400.18/1022.
    doi: 10.1080/15287394.2012.690690
  18. Plasma and red blood cell proteome in sickle-cell disease. Sickle-cell disease (SCD) is a clinically heterogeneous autosomal recessive monogenic chronic anaemia characterized by recurrent episodes of severe vaso-occlusion, haemolysis and infection. Painful crises are the major SCD clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies. 2012. Charro, Nuno; Vaz, Fatima; Morais, Anabela; Lavinha, João; Penque, Deborah. http://hdl.handle.net/10400.18/1285.
  19. Proteomics in Detection and Monitoring Chronic Lung Diseases: The Human Nasal Epithelium as a Molecular Model. Asthma and chronic obstructive pulmonary disease (COPD) are major causes of mortality and morbidity worldwide. The current state-of-art diagnosis and management schemes are suboptimal for both diseases as the incidence of asthma has risen by 250% over the last two decades and COPD is estimated to become the third leading cause of death worldwide within the next decade. Additionally, these diseases. 2012. Simões, Tânia; Charro, Nuno; Alexandre, Bruno; Penque, Deborah. http://hdl.handle.net/10400.18/1021.
    J Aller Ther 2012, S7. doi:10.4172/2155-6121.S7-004
  20. Chronic Obstructive Pulmonary Disease and Proteomics: A Match for Success?. Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation that is not fully reversible even under bronchodilators effect, caused by a mixture of small airway disease and parenchymal destruction. COPD is a major cause of morbidity and mortality in adults, and it is now the fourth leading death cause in the world. Cigarette smoking is the main risk factor for COPD b. 2012. Alexandre, Bruno; Penque, Deborah. http://hdl.handle.net/10400.18/1023.
    J Aller Ther 2012, S7:003. doi: 10.4172/2155-6121.S7-003
  21. Profiling the erythrocyte membrane proteome isolated from patients diagnosed with chronic obstructive pulmonary disease. Structural and metabolic alterations in erythrocytes play an important role in the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD). Whether these dysfunctions are related to the modulation of erythrocyte membrane proteins in patients diagnosed with COPD remains to be determined. Herein, a comparative proteomic profiling of the erythrocyte membrane fraction isolated from peripheral. 2012. Alexandre, Bruno; Charro, Nuno; Blonder, Yosip; Lopes, Carlos; Almeida, Antonio Bugalho; Veenstra, Timothy; Penque, Deborah; et al. http://hdl.handle.net/10400.18/869.
  22. The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae. n Saccharomyces cerevisiae, adaptation to hydrogen peroxide (H2O2) decreases plasma membrane permeability to H2O2, changes its lipid composition and reorganizes ergosterol-rich microdomains by a still unknown mechanism. Here we show, by a quantitative analysis of the H2O2-induced adaptation effect on the S. cerevisiae plasma membrane-enriched fraction proteome, using two-dimensional gel electropho. 2012. Pedroso, Nuno; Gomes Alves, Patricia; Marinho, H. Susana; Brito, Veronica; Boada, Cristina; Antunes, Fernando; Herrero, Enrique; Penque, Deborah; Cyrne, Luísa. http://hdl.handle.net/10400.18/1283.
    doi: 10.3109/10715762.2012.704997
  23. Supramolecular organizations in the aerobic respiratory chain of Escherichia coli. The organization of respiratory chain complexes in supercomplexes has been shown in the mitochondria of several eukaryotes and in the cell membranes of some bacteria. These supercomplexes are suggested to be important for oxidative phosphorylation efficiency and to prevent the formation of reactive oxygen species. Here we describe, for the first time, the identification of supramolecular organizat. 2011. Sousa, Pedro M.F; Silva, Sara T.N.; Hood, Brian L.; Charro, Nuno; Carita, João N.; Vaz, Fátima; Penque, Deborah; Conrads, Thomas P.; Melo, Ana M.P.. http://hdl.handle.net/10400.18/126.
    doi:10.1016/j.biochi.2010.10.014
  24. Proteomics advances in the last decade: What is next?. During the first decade of this millennium, we have witnessed of the most remarkable advances in the field of proteomics since the word proteome was introduced by Marc Wilkins in 1995. High degree of technical innovations has been successfully achieved to meet the ongoing challenges mostly associated with the need to know and map all proteins, their variants and functional networks in a given cell. 2011. Penque, Deborah; Simoes, Tania; Amado, Francisco. http://hdl.handle.net/10400.18/531.
    doi:10.1016/j.jprot.2011.10.024
  25. The transition of the European Proteomics Association into the future. The following report provides an overview of the discussions and outcome of the EuPA General Council meeting that took place in Estoril 20–21 October 2010. During the annual meeting future policy and action plans in a variety of areas are decided. Several important points were decided upon during this meeting including the expansion of the EuPA Executive Committee by introducing a new EuPA committ. 2011. Corthals, Gerry L.; Dunn, Mike; James, Peter; Gil, Concha; Penque, Deborah; Albar, Juan Pablo; Andrén, Per; Rabilloud, Thierry; Marko-Varga, Gyorgy. http://hdl.handle.net/10400.18/266.
    ESSN: 1876-7737doi:10.1016/j.jprot.2011.06.018
  26. Molecular profiling of the human nasal epithelium: a proteomics approach. A comprehensive proteomic profiling of nasal epithelium (NE) is described. This study relies on simple subcellular fractionation used to obtain soluble- and membrane-enriched fractions followed by 2-dimensional liquid chromatography (2D-LC) separation and tandem mass spectrometry (MS/MS). The cells were collected using a brushing technique applied on NE of clinically evaluated volunteers. Subseque. 2011. Simoes, Tania; Charro, Nuno; Blonder, Josip; Faria, Daniel; Couto, Francisco; Chan, King C.; Waybright, Timothy; et al. http://hdl.handle.net/10400.18/295.
    ESSN: 1876-7737doi:10.1016/j.jprot.2011.05.012
  27. Serum proteomics signature of Cystic Fibrosis patients: A complementary 2-DE and LC–MS/MS approach. Complementary 2D-PAGE and ‘shotgun’ LC–MS/MS approaches were combined to identify medium and low-abundant proteins in sera of Cystic Fibrosis (CF) patients (mild or severe pulmonary disease) in comparison with healthy CF-carrier and non-CF carrier individuals aiming to gain deeper insights into the pathogenesis of this multifactorial genetic disease. 78 differentially expressed spots were identifi. 2011. Charro, Nuno; Hood, Brian L.; Faria, Daniel; Pacheco, Paula; Azevedo, Pilar; Lopes, Carlos; Bugalho de Almeida, António; et al. http://hdl.handle.net/10400.18/125.
    doi:10.1016/j.jprot.2010.10.001
  28. Facing challenges in Proteomics today and in the coming decade: Report of Roundtable Discussions at the 4th EuPA Scientific Meeting, Portugal, Estoril 2010. Roundtable Discussion sessions were conceived for the first time at the 4th Edition of the EuPA Annual Scientific Meeting that took place in Estoril, Portugal, from the 23rd to 27th of October, 2010. Under the theme “2010: a proteomics odyssey towards the next decades”, young and senior scientists had the opportunity to discuss particular issues of different proteomic areas s distributed by eleven. 2011. Cox, Jurgen; Heeren, Ron M.A.; James, Peter; Jorrin-Novo, Jesús V.; Kolker, Eugene; Levander, Fredrik; Morrice, Nicholas; et al. http://hdl.handle.net/10400.18/127.
    J Proteomics. 2011 May 3. doi:10.1016/j.jprot.2011.04.021
  29. Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response. F508del-CFTR, the most common mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, disrupts intracellular trafficking leading to cystic fibrosis (CF). The trafficking defect of F508del-CFTR can be rescued by simultaneous inactivation of its four RXR motifs (4RK). Proteins involved in the F508del-CFTR trafficking defect and/or rescue are therefore potential CF therape. 2010. Gomes-Alves, Patrícia; Couto, Francisco; Pesquita, Cátia; Coelho, Ana V.; Penque, Deborah. http://hdl.handle.net/10400.18/155.
    doi:10.1016/j.bbapap.2009.12.013
  30. Proteomics uncovering possible key players in F508del-CFTR processing and trafficking. The achievement and maintenance of a protein native conformation is a very complex cellular process involving a multitude of key factors whose contribution to a successful folding remains to be elucidated. On top of this, it is known that correct folding is crucial for proteins to play their normal role and, consequently, for the maintenance of cellular homeostasis or proteostasis. If the folding. 2010. Gomes-Alves, Patrícia; Penque, Deborah. http://hdl.handle.net/10400.18/133.
  31. Diagnostic and prognostic biomarker discovery strategies for autoimmune disorders. Current clinical, laboratory or radiological parameters cannot accurately diagnose or predict disease outcomes in a range of autoimmune disorders. Biomarkers which can diagnose at an earlier time point, predict outcome or help guide therapeutic strategies in autoimmune diseases could improve clinical management of this broad group of debilitating disorders. Additionally, there is a growing need fo. 2010. Gibson, David S.; Banha, João; Penque, Deborah; Costa, Luciana; Conrads, Thomas P.; Cahill, Dolores J.; O'Brien, John K.; Rooney, Madeleine E.. http://hdl.handle.net/10400.18/156.
    doi:10.1016/j.jprot.2009.11.013
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017 - 2017 Molecular effects of continuous positive airway pressure therapy in patients with obstructive sleep apnea: a proteomics approach
Supervisor
 Biotecnologia (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2008 - 2008 Identification of Differentially Expressed Proteins in Cystic Ficrosis by Proteomics
Supervisor
 Biologia (PhD)
Universidade de Lisboa, Portugal
2007 - 2007 Chronic Obstructive Pulmonary Disease: A Proteomics Approach
Supervisor
 Biologia (PhD)
Universidade de Lisboa, Portugal
2007 - 2007 Towards the identification of biomarkers for cystic fibrosis by proteomics.
Supervisor
 Biologia (PhD)
Universidade de Lisboa, Portugal
2005 - 2005 Protein Profiles of Cystic Fibrosis Nasal Cells. Characterization of Mutant and Revertant Forms of the Cftr Protein
Supervisor
 Bioquímica (PhD)
Universidade de Lisboa, Portugal
2004 - 2004 Expression, Localization and Traffic of Wild-type and Mutant Cftr
Supervisor
 Biologia (PhD)
Universidade de Lisboa, Portugal
2004 - 2004 Cystic Fibrosis by Proteomics: Identification of Molecular Targets for Therapeutic Intervention
Supervisor
 Biologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2010 - 2013 Proteomics Photo & Graphic Art Contest. A European Proteomics Association Initiative. (2010 - 2013)
Exhibition (President of the Organising Committee)
 European Proteomics Association, Austria

Association member

Society Organization name Role
2020 - Current Chair of the General Council of Rede-ProCura- Portuguese Proteomics Association Chair
2006 - Current Vogal of the Audit Committee of the Pro-INSA- Associação para a Promoção da Investigação em Saúde Dr Ricardo Jorge Vogal of the Audit Committee
2003 - Current INSA-Node Representative at The Portuguese Mass Spectrometry Network-FCT Strategic Infrastructure of National Interest
2009 - 2019 Presidente of The Portuguese Proteomics Association- Rede-ProCura Founder and former Presidente
2003 - 2005 Chair of General Council of the Pro-INSA– Associação para a Promoção da Investigação em Saúde Dr Ricardo Jorge

Committee member

Activity description
Role 		Institution / Organization
2019 - Current Co-Chair of the Publication Committee of the Human Proteome Organization (HUPO)
Coordinator
2010 - Current European Proteomics Association (EuPA)- Conference Communication Committee
2005 - 2010 The European Proteomics Association Education Committee (EuPA-EC)

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2010 - Current Agence Nationale du Reserche-France-Appel à projets Cohortes
Evaluator
 Agence nationale de la recherche, France
2015 - 2015 Progress Assessment of Science Foundation Ireland-funded Starting Investigator Research Grant (SIRG) Programme (SFI 11/SIRG/B2165 ‘Characterisation of Hsp90 trafficking pathways in cystic fibrosis. PI: Dr Judith Coppinger;
Evaluator
 Science Foundation Ireland, Ireland
2014 - 2014 Tender within the Programme to support medical applied research and development in 2015 to 2022 - National Priority Healthy Population- Improving knowledge in the area of omics and high-capacity methods. Ministry of Health of the Czech Republic – Starting Investigator Research Grant (SIRG) Programme; Ministerstvo zdravotnictví Ceské republiky, Czech Republic
2013 - 2013 Fundação da Ciência e a Tecnologica (FCT) Investigator Grants
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal
2003 - 2003 Project Call - French Cystic Fibrosis Association -Vaincre la Mucoviscidose.
Evaluator
 Association Vaincre la Mucoviscidose, France

Journal scientific committee

Journal title (ISSN) Publisher
2011/01/01 - Current Associated Editor-Europe of the Journal of Integrated OMICS: a methodological journal (ISSN 2182-0287) Scopus
2008/01/01 - Current member of the Editorial Board of the Journal of Proteomics - Elsevier (ISSN: 1874-3919) Elsevie

Other jury / evaluation

Activity description Institution / Organization
2018 - 2018 Best Poster Presentation at the XI Congress of European Proteomics Association (EuPA), a join meeting with the Spanish Proteomics Society (SeProt) and Rede-ProCura- the Portuguese Proteomics Association, Santiago de Compostela, Spain, June 16-20, 2018.
2014 - 2014 Best Young Investigator Award at 13th Annual Meeting of Human Proteome Organization (HUPO) joining European Proteomics Association (EuPA), Madrid, October 5-8, 2014
2012/07/09 - 2012/07/09 Best Young Investigator Award at the European Proteomics Association (EuPA) & British Society for Proteome Research (BSPR), Glasgow, UK, July 9-10, 2012
2010 - 2010 Best Young Investigator Award at the 4th European Proteomics Association (EuPA) & 6th ProCura-the Portuguese Proteomics Association Meeting, Estoril, Portugal, October 23-27, 2010
2007 - 2007 Best Poster Communication at the 4th Meeting of the Portuguese Proteomics Network (ProCura) & 1rst National Mass Spectrometry Network (RNEM), Aveiro, Portugal, November 10-11, 2007.
2007 - 2007 Best Poster Communication at the 2nd Congress of the Spanish Proteomics Society (SeProt) & 1rst Meeting of the European Proteomics Association (EuPA). Valencia, Spain, February 10-14, 2007.
Distinctions

Award

2022 Medal of Merit - Communication Prize at the 3rd INSARJ's Young Investigator's Day. Neves S, Pacheco S, Vaz F, James P, Simoes T, Penque D. Occupational secondhand smoke exposure: a proteomic approach.
Instituto Nacional de Saude Dr Ricardo Jorge, Portugal
2022 Excellent Poster Presentation Prize: Valentim-Coelho C, Osorio H, Vaz F, Neves S, Pinto P, Bárbara C, Penque D. Shotgun proteomics approach to better understand the the regulation of RBC in OSA and OSA response to PAP treatment
PROTEOMASS Scientifc Society , Portugal
2022 Excellent ShotGun Communication Prize - Saraiva J, Valentim-Coelho C, et al. COVID-19 vaccination: a a study o red blood cells and their impact in the immunosystem by omics-based approaches.
Associação Científica Proteomass, Portugal
2022 Society Award Merit
Portuguese Proteomics Association - Rede ProCura , Portugal
2016 Best Poster Award Winner at Meeting - Lufada 2016, Lisbon: Marçôa R, Linhas R, Feliciano A, Cysneiros A, Basto RP, Martinho C, Silva AM, Pinto P, Penque D, Bárbara C. Relação entre a dispersão dos volumes eritrocitários (RDW) e a gravidade da SAOS
Sociedade Portuguesa de Pneumologia, Portugal
2016 SPP/Pfizer Vaccines Award for the best scientific work published: Feliciano A, Torres VM, Vaz F, Carvalho AS, Matthiesen R, Pinto P, Malhotra A, Bárbara C, Penque D (2015). Overview of proteomics studies in obstructive sleep apnea. Sleep Medicine 16(4):43
Sociedade Portuguesa de Pneumologia, Portugal
2014 Best Poster Award Winner at -Fórum das Bolsas Universidade de Lisboa / Fundação Amadeu Dias¿: Drumond AM, Vaz F, Vukosava MT, Neves J, Penque D, Barata B. Proteómica de exsudados em feridas crónicas e em pé diabético: a procura de biomarcadores diferencia
2012 2012 Arnaldo Sampaio Award Winner for the best scientific work in Public Health : S Pacheco, Aguiar F, Ruivo P, Proença MC, Sekera M, Penque D, Simões T. Exposição ocupacional ao fumo de tabaco ambiental: um estudo em restaurantes na cidade de Lisboa
2009 Best poster in Medical Proteomics awarded by the scientific community on the 5th Meeting of the Portuguese Proteomics Network (ProCura) & the 1st International Congress on Analytical Proteomics (ICAP); Costa de Caparica, Portugal, Sept. 30th – Oct. 3rd. P
2006 The best scientifc project in the liver disease area
2004 Best Basic Science Poster Presentation at the 2004 ECFS Conference
European Cystic Fibrosis Society, Denmark
2001 Best Basic Science Poster Presentation at the 24th European CF Conference,Vienna June 2001.
European Cystic Fibrosis Society, Denmark