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Marta Rafael completed her PhD in Biochemistry in 2011 at Universidade do Algarve. During her Pos-Doc she worked in straight collaboration with basic and clinical researchers investigating the molecular mechanisms underlaying the development of ectopic calcification. She published 11 articles in sientific journals. In her professional activities interacted with 58 collaborator(s) co-authorship of scientific papers. She then pursued a carreer in Science Management working as a Scientific Officer at Fundação para a Ciência e a Tecnologia since 2015.
Identification

Personal identification

Full name
Marta Rafael
Gender
Female

Citation names

  • Rafael, Marta S.

Author identifiers

Ciência ID
8311-0464-1380
ORCID iD
0000-0002-5518-9790

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Natural sciences
  • Natural sciences - Biological Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2006/01/01 - 2011/06/01
Concluded
 Bioquímica (Doutoramento)
Major in Especialidade: Biologia Celular e Molecular
Universidade do Algarve Faculdade de Ciencias e Tecnologia, Portugal
"Role of the Transcriptional Regulator Fhl2 in Bone Formation: Identification of Fish Bone-specific Target Genes and Regulatory Mechanisms" (THESIS/DISSERTATION)
1999/09/01 - 2004/11/18
Concluded
 Bioquímica (Licenciatura)
Universidade do Algarve Faculdade de Ciencias e Tecnologia, Portugal
Affiliation

Science

Category
Host institution 		Employer
2025/03/31 - Current Science and Technology Management Centro de Ciências do Mar, Portugal
Centro de Ciencias do Mar, Portugal
2015/05/15 - 2025/03/30 Science and Technology Management Fundacao para a Ciencia e a Tecnologia, Portugal
Fundacao para a Ciencia e a Tecnologia, Portugal
2011/09/01 - 2015/05/16 Postdoc (Research) Fundacao para a Ciencia e a Tecnologia, Portugal
Centro de Ciencias do Mar, Portugal
2010/01/01 - 2011/07/31 Research Assistant (Research) Centro de Ciencias do Mar, Portugal
Projects

Contract

Designation Funders
2025/03/31 - 2031/03/30 Gestão de Operações de Ciência e Tecnologia no CCMAR – Implementação estratégica do CCMAR
CEECINSTLA/00028/2022/CP2990/CT0003
10.54499/CEECINSTLA/00028/2022/CP2990/CT0003
Universidade do Algarve Centro de Ciências do Mar, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2012/02/01 - 2015/09/30 Insights into Gla-rich Protein (GRP) function and molecular mechanism of action in vascular calcification (BioGlaGRP)
PTDC/SAU-ORG/117266/2010
Post-doc
Centro de Ciências do Mar, Portugal

Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands

Hospital de Faro, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/01/01 - 2015/05/01 New insights into the mechanism of vascular calcification in chronic kidney disease (CKD): the role of GRP
PTDC/BIM-MEC/1168/2012
Post-doc
2010/01/01 - 2013/07/31 Studies for the establishment of GRP as a biomarker for vascular calcification
PTDC/SAU-ESA/101186/2008
Post-doc Fellow
Universidade do Algarve, Portugal

Hospital de Faro, Portugal

Centro de Ciências do Mar, Portugal

Centro Hospitalar Universitário de Lisboa Central EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Viegas, Carla; Edelweiss, Evelina; Schneider, Justine; Schaeffer-Reiss, Christine; Poterszman, Arnaud; Rafael, Marta S.; Araújo, Nuna; et al. "Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP)". Annals of Medicine 51 sup1 (2019): 38-38. http://dx.doi.org/10.1080/07853890.2018.1561804.
    10.1080/07853890.2018.1561804
  2. Brecht A. Willems; Malgorzata Furmanik; Marjolein M. J. Caron; Martijn L. L. Chatrou; Dennis H. M. Kusters; Tim J. M. Welting; Michael Stock; et al. "Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling". Scientific Reports 8 1 (2018): https://doi.org/10.1038%2Fs41598-018-23353-y.
    10.1016/j.bone.2006.06.021
  3. Cavaco S; Viegas CS; Rafael MS; Ramos A; Magalhães J; Blanco FJ; Vermeer C; Simes DC. "Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis.". (2015): http://europepmc.org/abstract/med/26337479.
    10.1155/2014/340216
  4. Viegas, C.S.B.; Rafael, M.S.; Enriquez, J.L.; Teixeira, A.; Vitorino, R.; Luís, I.M.; Costa, R.M.; et al. "Gla-rich protein acts as a calcification inhibitor in the human cardiovascular system". Arteriosclerosis, Thrombosis, and Vascular Biology 35 2 (2015): 399-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922014561&partnerID=MN8TOARS.
    10.1161/ATVBAHA.114.304823
  5. Marta S. Rafael; Sofia Cavaco; Carla S. B. Viegas; Sofia Santos; Acácio Ramos; Brecht A. G. Willems; Marjolein Herfs; et al. "Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and ¿-carboxylation status". Molecular Nutrition & Food Research 58 8 (2014): 1636-1646. http://dx.doi.org/10.1002/mnfr.201300941.
    10.1007/s00018-011-0754-y
  6. Viegas, C.S.B.; Herfs, M.; Rafael, M.S.; Enriquez, J.L.; Teixeira, A.; Luís, I.M.; Van 'T Hoofd, C.M.R.; et al. "Gla-rich protein is a potential new vitamin K target in cancer: Evidences for a direct GRP-mineral interaction". BioMed Research International 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84902129958&partnerID=MN8TOARS.
    10.1002/mnfr.201300941
  7. Rafael, M.S.; Laizé, V.; Bensimon-Brito, A.; Leite, R.B.; Schüle, R.; Cancela, M.L.. "Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata". Cellular and Molecular Life Sciences 69 3 (2012): 423-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856224817&partnerID=MN8TOARS.
    10.1016/j.biochi.2012.01.013
  8. Rafael, M.S.; Laizé, V.; Florindo, C.; Ferraresso, S.; Bargelloni, L.; Cancela, M.L.. "Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts". Biochimie 94 5 (2012): 1128-1134. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859426121&partnerID=MN8TOARS.
    10.1038/s41598-018-23353-y
  9. Rafael, M.S.; Marques, C.L.; Parameswaran, V.; Cancela, M.L.; Laizé, V.. "Fish bone-derived cell lines: An alternative in vitro cell system to study bone biology". Journal of Applied Ichthyology 26 2 (2010): 230-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954202980&partnerID=MN8TOARS.
    10.1111/j.1439-0426.2010.01411.x
  10. Marques, C.L.; Rafael, M.S.; Cancela, M.L.; Laizé, V.. "Establishment of primary cell cultures from fish calcified tissues". Cytotechnology 55 1 (2007): 9-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-35448950931&partnerID=MN8TOARS.
  11. Rafael, M.S.; Laizé, V.; Cancela, M.L.. "Identification of Sparus aurata bone morphogenetic protein 2: Molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates". Bone 39 6 (2006): 1373-1381. http://www.scopus.com/inward/record.url?eid=2-s2.0-35448991288&partnerID=MN8TOARS.
    10.1007/s10616-007-9098-8
Activities

Consulting

Activity description Institution / Organization
2020/01/01 - 2021/09/30 Deputada da iniciativa Health Parliament Portugual Universidade Nova de Lisboa, Portugal

Microsoft Portugal, Portugal
Distinctions

Award

2012 Bolsa de Pós-Doutoramento - SFRH/BPD/89188/2012
Fundação para a Ciência e a Tecnologia, Portugal
2008 Melhor Comunicação em Painel - Reunião Final Marine Genomics Europe
Marine Genomics Europe, Portugal
2005 Bolsa de Doutoramento - SFRH/BD/22695/2005
Fundação para a Ciência e a Tecnologia, Portugal
2004 Bolsa de estudo de Mérito
Universidade do Algarve - Campus de Gambelas, Portugal