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Marta Martins has accomplished her Biochemistry degree in 2005, attributed by the Faculty of Sciences of the University of Porto, Portugal. In the same year, Marta successfully obtained a fellowship from the French Minister of Science to initiate her PhD degree at the University of Paris VII - Denis Diderot, France, in the field of Protein Engineering, Function and Structure. Her PhD degree was successfully completed with honours at the end of 2008, after several publications in peer-review journals and participation in a book chapter. Beginning of 2009, Marta started her first postdoctoral position, funded by Cancer Research UK, in the laboratory of Dr. Matilda Katan at the Institute of Cancer Research (ICR), London, which later moved to University College London (UCL). At Dr. Katan Laboratory, Marta studied the role of phospholipase C (PLC) family of enzymes on cancer development. Her efforts gave rise to two first author publications in Journal of Cell Science and in Proceedings of the National Academy of Sciences, and several collaborative works, including one publication in New England Journal of Medicine. During her stay in London, Marta has also lectured Cellular and Molecular Biology, and Lab Techniques of Mammalian Cell Biology at UCL. To continue developing her independent projects about the role of PLCs in human cancers, Marta Martins moved to Portugal in 2014 and integrated the laboratory of Translational Oncology headed by Prof. Luís Costa at Instituto de Medicina Molecular (IMM) in Lisbon. Over this period, Marta was awarded a research grant in 2013 (EXPL/BIM-ONC/1048/2013) and an Investigador FCT Contract (IF/00409/2014) in 2014 from Fundação para a Ciência e Tecnologia (FCT). Marta was further awarded of a Terry Fox grant from Liga Portuguesa Contra o Cancro and a Merit Award from Grupo de Investigação em Cancro Digestivo (GICD)/Bayer in 2015. After being the mother of two children (2015 and 2021), the first of which a premature born at 29 weeks, which necessarily forced her to step back from research for several months, Marta´s commitment and resilience resulted in a manuscript published at Clinical Cancer Research (IF: 13.8, doi: 10.1158/1078-0432.CCR-21-1992, 2022). Marta is the last and corresponding author of this work that reports the relevance of PLCy1 in resistance to anti-EGFR therapy cetuximab in colorectal cancer (CRC). Importantly, in 2022 Marta was also the co-last and co-corresponding author of a manuscript showing the relevance of a natural compound named deflamin on CRC development and progression published at Cancers (IF: 6.639, doi: 10.3390/cancers14246182, 2022), and the co-first author of a work reporting the genetic and microenvironmental intra-tumor heterogeneity of CRC published at Communications Biology (IF: 6.548, doi:10.1038/s42003-022-03884-x, 2022). Overall, Marta Martins has a record of more than 34 peer-reviewed publications (20 of which published in the last 5 years), 1300 citations and an h-index of 17 (by Scopus), contributing as a supervisor and/or examiner in more than 14 PhD/Master thesis. Already in 2023, Marta was awarded the Liga Portuguesa contra o Cancro grant in CRC - João & Natália to continue her work about PLCy1 and cetuximab resistance in CRC. Marta is now a Professor of Oncobiology at Faculdade de Medicina da Universidade de Lisboa, and Biochemistry at Universidade Lusófona and is a guest editor at Frontiers in Oncology, Biomedicines and Cancers. Finally, during the years Marta has acquired a vast portfolio of national and international collaborators (such as Prof. Fernanda Marques from Instituto Superior Tecnico; Prof. Ricardo Ferreira Instituto Superior de Agronomia; Prof. Matilda Katan from UCL; and Dr. Isaac Garcia-Murillas from ICR) who will be important supporters of her future scientific career.
Identification

Personal identification

Full name
Marta Sofia Alves Martins

Citation names

  • Martins, Marta

Author identifiers

Ciência ID
8310-DA72-78B6
ORCID iD
0000-0003-0429-9380
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=OwVOulgAAAAJ
Researcher Id
A-9905-2013
Scopus Author Id
55268246400

Email addresses

  • marta.martins@medicina.ulisboa.pt (Professional)

Addresses

  • Instituto de Medicina Molecular. Av. Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences
  • Medical and Health Sciences - Basic Medicine
  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2023/05/01 - 2023/05/05
Concluded
Course on Laboratory Animal Science for Functions A + B +C. (Curso de Especialização Tecnológica)
Gulbenkian Institute for Molecular Medicine, Portugal
2017 - 2017
Concluded
Personal Licence for Scientific Procedures in Living Animals (Curso de Especialização Tecnológica)
Instituto de Medicina Molecular, Portugal
2009 - 2009
Concluded
Personal Licence for Scientific Procedures in Living Animals (Postgraduate Certificate)
Institute of Cancer Research Division of Cancer Biology, United Kingdom
2005/09/01 - 2008/12/08
Concluded
Structure, Function and Engineering of Proteins (Doctorat)
Major in Biochemistry and Molecular Biology
Université Paris Diderot, France
"Characterization of arylamine N-acetyltransferases enzymes from Podospora anserina filamentous fungus and Nocardia farcinica bacterium: Environmental and Therapeutic Implication" (THESIS/DISSERTATION)
With honours
2005
Concluded
Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
""Anti-proliferative activity of CCN3 enzyme in fibroblasts" - ERASMUS Student in Université Paris 7- France " (THESIS/DISSERTATION)
14/20
2001
Concluded
Ciências (Ensino secundário)
Escola Secundária Rodrigues de Freitas, Portugal
18,84
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2023/09/01 - Current Assistant Professor (University Teacher) Ensino Lusófona, Portugal
Universidade Lusófona de Humanidades e Tecnologias Faculdade de Medicina Veterinária, Portugal

Others

Category
Host institution
Employer
2024 - Current Assistant Researcher- Multi-Cancer Profile Project Gulbenkian Institute for Molecular Medicine, Portugal
2022/04 - 2024/03 Auxiliary Researcher- Deflamin beverages against colorectal cancer Instituto de Medicina Molecular, Portugal
2020 - 2022 Assistant Researcher- Multi-Cancer Profile Project Instituto de Medicina Molecular, Portugal
2015/02/01 - 2020 Assistant Researcher- Investigador FCT (IF/00409/2014) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2014/04/01 - 2015/02/01 Postdoctoral studies in Cancer Biology Subject: “Mechanisms and relevance of Phospholipase C epsilon downregulation in Colorectal cancer.” Supervisor: Prof. Luis Costa. FCT funded project. Instituto de Medicina Molecular, Portugal
2013/09/01 - 2014/03/31 Postdoctoral studies in Cancer Biology Subject: “Creating new cell lines of flies to be used as a model of intestinal cancer.” Supervisor: Dr. Ivana Bjedov. ERC funded project. University College London Cancer Institute, United Kingdom
2009/01/01 - 2013/12/31 Post-doctoral studies in Cellular and Molecular Biology focusing on the role of Phospholipase C epsilon, an effector protein of the oncogene Ras, in cancer mouse models. CRUK funded project Institute of Cancer Research Division of Cancer Biology, United Kingdom
2013/03/01 - 2013/08/31 Post-doctoral studies in Structural and Molecular Biology- "Functional and structural characterization of von Willebrand factor mutations in patients with blood disease". Supervisor: Flemming Hansen. University College London, United Kingdom
2006/01/01 - 2008/12/31 Doctorat- “Role of arylamine N-acetyltransferases enzymes from Podospora anserina and Nocardia farcinica: Environmental and Therapeutic Implication”- French Ministry Fellowship Université Paris Diderot, France
Projects

Grant

Designation Funders
2025 - 2027 Development of a clinical decision support tool to predict disease progression in patients with metastatic breast cancer.
2024.07424.IACDC
Researcher
Ongoing
2025/09/01 - 2026/08/31 Sarcoma Clinical Data Integration with AI-Driven Automation for the National Oncology Registry
2024.07252.IACDC
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2026 Innovative approaches for pancreatic cancer: Decoding and manipulating the immune response to sialylated O-glycans.
2022.04607.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2023/04/15 - 2024 PLCy1 expression in circulating tumour cells as a new biomarker of cetuximab responses in metastatic colorrectal cancer
João e Natália
Principal investigator
Instituto de Medicina Molecular, Portugal
Liga Portuguesa Contra o Cancro
Ongoing
2018/11/01 - 2022/10/31 Phospholipase C signalling in resistance to anti-RTK therapy
SFRH/BD/139138/2018
Supervisor
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2019 Predictive role of PLCg1 in cetuximab responses
FPJ885
Principal investigator
Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular
Concluded
2017 - 2018 Study PLCe SNP rs2274223 in a Portuguese population of colorectal cancer patients
GAPIC 201780607
Supervisor
Universidade de Lisboa, Portugal
Universidade de Lisboa
Concluded
2016 - 2018 Involvement of PLCg1 in the Resistance Mechanism to anti-EGFR therapy in Metastatic Colorectal Cancer
LPCC-NRS/Terry Fox 2016-2017
Principal investigator
Instituto de Medicina Molecular, Portugal
Liga Portuguesa Contra o Cancro
Concluded
2014/04/01 - 2015/03/31 Mechanisms and relevance of Phospholipase C epsilon downregulations in colorectal cancer
EXPL/BIM-ONC/1048/2013
Principal investigator
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Instituto de Medicina Molecular João Lobo Antunes
LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/02/01 - 2024/02/01 Development of lupine and ckickpea-based beverages as functional food against colorectal cancer
PTDC/OCE-ETA/4836/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2020/02/01 - 2022/01/01 Multi-Cancer Profile Project
MCPP
Researcher
Instituto de Medicina Molecular, Portugal
Merk Serono
Concluded
2015/02/01 - 2020/01/31 Role of Phospholipase C epsilon as a Biomarker of Colorectal Cancer Progression
IF/00409/2014
Principal investigator
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular - IMM
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2013 Phospholipase C epsilon role in cancer mouse models
contract
Researcher
Institute of Cancer Research Chester Beatty Laboratories, United Kingdom
Cancer Research UK
Concluded
2005/10/01 - 2008/09/30 Role of arylamine N-acetyltransferases enzymes from Podospora anserina filamentous fungus and Nocardia farcinica bacterium: Environmental and Therapeutic Implication
French Ministry of l'Enseignement supérieur de la Recherche et de l'Innovation
PhD Student Fellow
Université Paris Diderot, France
Gouvernement francais Ministère de l'Enseignement supérieur de la Recherche et de l'Innovation
Concluded
Outputs

Publications

Book chapter
  1. Ana João Pissarra; Catarina Abreu; André Mansinho; Ana Lúcia Costa; Sara Dâmaso; Soraia Lobo-Martins; Martins, Marta; Luís Costa. "Landscape of current targeted therapies for advanced colorectal cancer". In Colorectal Cancer. Intechopen, 2020.
    Published
  2. Martins, Marta; Mansinho, André; Cruz-Duarte, Raquel; Martins, Soraia Lobo; Costa, Luís. "Anti-EGFR Therapy to Treat Metastatic Colorectal Cancer: Not for All". In Targeted Therapy of Colorectal Cancer Subtypes, 113-131. Springer International Publishing, 2018.
    10.1007/978-3-030-02771-1_8
  3. Dupret, Jean-Marie; Dairou, Julien; Busi, Florent; Silar, Philippe; Martins, Marta; Mougin, Christian; Rodrigues-Lima, Fernando; Cocaig, Angelique. "Pesticide-Derived Aromatic Amines and Their Biotransformation". In Pesticides in the Modern World - Pests Control and Pesticides Exposure and Toxicity Assessment. InTech, 2011.
    10.5772/18279
Conference abstract
  1. Lobo-Martins, Soraia; Corredeira, Patrícia; Alves, Patrícia Borges; Antunes, Marília; Rodrigues, Ângela; Quintela, António; Mansinho, André; et al. "Abstract PS17-37: Immune cell populations in peripheral blood of metastatic breast cancer patients under CDK4/6 inhibitors". Paper presented in San Antonio Breast Cancer Virtual Symposium, San Antonio, Texas, 2021.
    10.1158/1538-7445.sabcs20-ps17-37
  2. Liu, L.; Garbutt, C.; Golkaram, M.; Kaplan, S.; Martins, M.; Casino, S.; Mansinho, A.; et al. "Microsatellite instability testing and lynch syndrome screening for colorectal cancer patients through tumour sequencing". 2019.
    10.1093/annonc/mdz257.001
Conference poster
  1. Elias Barreira; Martins, Marta; Luis Costa; João Guimarães. "Developing Genomic Models to Predict Breast Cancer Metastatic Progression". Paper presented in Bioinformatics Open Days 2025, 2025.
  2. Carolina Peixoto; Marta Lopes; Martins, Marta; Luis Costa; Susana Vinga. "Biomarker selection in survival colorectal cancer data using correlation based regularization.". Paper presented in EMBL Conference Cancer Genomics, 2021.
  3. Luis Costa; Patricia Corredeira; Patrícia Alves; Marília Antunes; Sara Dâmaso; Soraia Lobo-Martins; Patrícia Semedo; et al. "Prospective analysis of immune cell populations in peripheral blood of Metastatic Breast Cancer Patients reveals selective T cell subset biases.". Paper presented in ASCO, 2021.
  4. Catarina Silveria; Carla Sousa; Patricia Corredeira; Martins, Marta; Soura AR; Da Cruz Paula A; Selenica P; et al. "LIQUID BIOPSY DETECTS THERAPY RESPONSE IN ADVANCED BREAST CANCER". Paper presented in EACR, 2020.
  5. André Mansinho; Luis Costa; Daniela Macedo; Nicholas Willumsen; M.A. Karsdal; Martins, Marta; Sandra Casimiro; et al. "P-208 Prognostic evaluation of pro-peptides from collagen type III (PRO-C3) and collagen type VI (PRO-C6) formation in patients with early and late stage colorectal cancer (CRC)". Paper presented in EACR-AACR-ASPIC, 2019.
  6. Carolina Peixoto; André Verissímo; Marta Martins; Luis Costa; Susana Vinga. "Transcriptomic analysis of colorectal tumoral and normal tissues: comparison of TCGA and GTEx RNAseq data". Paper presented in EMBO workshop 2019, 2019.
  7. Lorenza Magno; Marta Martins; Christian B. Lessard,; Lang, Verena; Matilda Katan; Jamie Bilsland; Tammaryn Lashley,; et al. "Expression and function of genetic variants of phospholipase c gamma2, a possible target for modulating microglial function in Alzheimer´s disease.". Paper presented in EMBO workshop in microglia 2018- Germany, 2018.
  8. Gallego-Paez, L; Martins, M; Barbosa-Morais, N. "PO-358 CELF2 at the core of a prognostic alternative splicing signature in colorectal cancer". 2018.
    10.1136/esmoopen-2018-eacr25.870
  9. Raquel Duarte; Teresa Pacheco; Afonso Fernandes; Luis Costa; Marta Martins. "Role of PLCg1 in the Resistance Mechanism to Anti-EGFR Therapy in Metastatic Colorectal Cancer". Paper presented in 24th Porto Cancer Meeting: Liquid Biopsy: Bringing Precision Medicine Closer to Oncology, Lisboa, Portugal May 2017, 2017.
  10. Martins, Marta; Benjamin Pluvinage; Julien Dairou; Fernando Rodrigues-Lima. "Cloning and functional characterization of two arylamine N-acetyltransferases genes in the soil fungus Podospora anserina.". Paper presented in 32e FEBS Congress, « Molecular Machines », Vienna, Austria, 2007.
Journal article
  1. Esperança-Martins, Miguel; Melo-Alvim, Cecília; Dâmaso, Sara; Lopes-Brás, Raquel; Peniche, Tânia; Nogueira-Costa, Gonçalo; Abreu, Catarina; et al. "Breast Sarcomas, Phyllodes Tumors, and Desmoid Tumors: Turning the Magnifying Glass on Rare and Aggressive Entities". Cancers 15 15 (2023): 3933. http://dx.doi.org/10.3390/cancers15153933.
    10.3390/cancers15153933
  2. Peixoto, Carolina; Lopes, Marta B.; Martins, Marta; Casimiro, Sandra; Sobral, Daniel; Grosso, Ana Rita; Abreu, Catarina; et al. "Identification of biomarkers predictive of metastasis development in early-stage colorectal cancer using network-based regularization". BMC Bioinformatics 24 1 (2023): http://dx.doi.org/10.1186/s12859-022-05104-z.
    10.1186/s12859-022-05104-z
  3. Silva, Sara; Cavaco, Ana; Basso, Bianca; Mota, Joana; Cruz-Duarte, Raquel; Costa, Miguel; Carvalho, Lara; et al. "Therapeutic Potential of Deflamin against Colorectal Cancer Development and Progression". Cancers 14 24 (2022): 6182. http://dx.doi.org/10.3390/cancers14246182.
    10.3390/cancers14246182
  4. Silveira, Catarina; Sousa, Ana Carla; Corredeira, Patrícia; Martins, Marta; Sousa, Ana Rita; Da Cruz Paula, Arnaud; Selenica, Pier; et al. "Comprehensive Genomic Profiling of Cell-Free Circulating Tumor DNA Detects Response to Ribociclib Plus Letrozole in a Patient with Metastatic Breast Cancer". Biomolecules 12 12 (2022): 1818. http://dx.doi.org/10.3390/biom12121818.
    Published • 10.3390/biom12121818
  5. Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; et al. "Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development". Communications Biology 5 1 (2022): http://dx.doi.org/10.1038/s42003-022-03884-x.
    Published • 10.1038/s42003-022-03884-x
  6. Peixoto, Carolina; Martins, Marta; Costa, Luís; Vinga, Susana. "Kidney Cancer Biomarker Selection Using Regularized Survival Models". Cells 11 15 (2022): 2311. http://dx.doi.org/10.3390/cells11152311.
    Published • 10.3390/cells11152311
  7. Le Gal, Yann; Filatre-Furcate, Agathe; Lorcy, Dominique; Jeannin, Olivier; Roisnel, Thierry; Dorcet, Vincent; Fontinha, Diana; et al. "Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes". International Journal of Molecular Sciences 23 13 (2022): 7146. http://dx.doi.org/10.3390/ijms23137146.
    Published • 10.3390/ijms23137146
  8. Cruz-Duarte, Raquel; de Almeida, Cátia R.; Negrão, Magda; Fernandes, Afonso; Borralho, Paula; Sobral, Daniel; Gallego-Paez, Lina M.; et al. Corresponding author: Martins, Marta. "Predictive and therapeutic implications of a novel PLCg1/SHP2-driven mechanism of cetuximab resistance in metastatic colorectal cancer.". Clinical Cancer Research (2022): clincanres.1992.2021. http://dx.doi.org/10.1158/1078-0432.ccr-21-1992.
    Published • 10.1158/1078-0432.ccr-21-1992
  9. Golkaram, Mahdi; Salmans, Michael L.; Kaplan, Shannon; Vijayaraghavan, Raakhee; Martins, Marta; Khan, Nafeesa; Garbutt, Cassandra; et al. "HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome". npj Genomic Medicine 6 1 (2021): http://dx.doi.org/10.1038/s41525-021-00177-w.
    Published • 10.1038/s41525-021-00177-w
  10. Peixoto, Carolina; Lopes, Marta B.; Martins, Marta; Costa, Luís; Vinga, Susana. "TCox: Correlation-Based Regularization Applied to Colorectal Cancer Survival Data". Biomedicines 8 11 (2020): 488. http://dx.doi.org/10.3390/biomedicines8110488.
    Published • 10.3390/biomedicines8110488
  11. Tabacaru, Aurel; Botezatu Dediu, Andreea Veronica; Mihaela Dinica, Rodica; Cârâc, Geta; Basliu, Vasile; Paula Cabral Campello, Maria; Silva, Francisco; et al. "Biological properties of a new mixed lanthanide(III) complex incorporating a dypiridinium ylide". Inorganica Chimica Acta 506 (2020): 119517. http://dx.doi.org/10.1016/j.ica.2020.119517.
    Published • 10.1016/j.ica.2020.119517
  12. Patel, Varsha M.; Flanagan, Charlotte E.; Martins, Marta; Jones, Christine L.; Butler, Rosie M.; Woollard, Wesley J.; Bakr, Farrah S.; et al. "Frequent and Persistent PLCG1 Mutations in Sézary Cells Directly Enhance PLCg1 Activity and Stimulate NFkB, AP-1, and NFAT Signaling". Journal of Investigative Dermatology 140 2 (2020): 380-389.e4. http://dx.doi.org/10.1016/j.jid.2019.07.693.
    10.1016/j.jid.2019.07.693
  13. Sousa, Sílvia A.; Leitão, Jorge H.; Silva, Rafaela A.L.; Belo, Dulce; Santos, Isabel C.; Guerreiro, Joana F.; Martins, Marta; et al. "On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities". Journal of Inorganic Biochemistry 202 (2020): 110904. http://dx.doi.org/10.1016/j.jinorgbio.2019.110904.
    10.1016/j.jinorgbio.2019.110904
  14. Gano, Lurdes; Pinheiro, Teresa; Matos, António P.; Tortosa, Francisco; Jorge, Tiago F.; Gonçalves, Maria S.; Martins, Marta; et al. "Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools". Anti-Cancer Agents in Medicinal Chemistry 19 10 (2019): 1262-1275. http://dx.doi.org/10.2174/1871520619666190318152726.
    10.2174/1871520619666190318152726
  15. Matos, Cristina P.; Addis, Yemataw; Nunes, Patrique; Barroso, Sónia; Alho, Irina; Martins, Marta; Matos, António P.A.; et al. "Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn(II) complexes". Journal of Inorganic Biochemistry 198 (2019): 110727. http://dx.doi.org/10.1016/j.jinorgbio.2019.110727.
    10.1016/j.jinorgbio.2019.110727
  16. Magno, Lorenza; Lessard, Christian B.; Martins, Marta; Lang, Verena; Cruz, Pedro; Asi, Yasmine; Katan, Matilda; et al. "Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph". Alzheimer's Research & Therapy 11 1 (2019): http://dx.doi.org/10.1186/s13195-019-0469-0.
    10.1186/s13195-019-0469-0
  17. Neves, João Farela; Doffinger, Rainer; Barcena-Morales, Gabriela; Martins, Catarina; Papapietro, Olivier; Plagnol, Vincent; Curtis, James; et al. "Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa". Frontiers in Immunology 9 (2018): http://dx.doi.org/10.3389/fimmu.2018.02863.
    10.3389/fimmu.2018.02863
  18. Koss, Hans; Bunney, Tom D.; Esposito, Diego; Martins, Marta; Katan, Matilda; Driscoll, Paul C.. "Dynamic Allostery in PLCg1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR". Biophysical Journal 115 1 (2018): 31-45. http://dx.doi.org/10.1016/j.bpj.2018.05.031.
    10.1016/j.bpj.2018.05.031
  19. Martins, M.; McCarthy, A.; Baxendale, R.; Guichard, S.; Magno, L.; Kessaris, N.; El-Bahrawy, M.; Yu, P.; Katan, M.. "Tumor suppressor role of phospholipase C  in Ras-triggered cancers". Proceedings of the National Academy of Sciences 111 11 (2014): 4239-4244. http://dx.doi.org/10.1073/pnas.1311500111.
    10.1073/pnas.1311500111
  20. Zhou, Qing; Lee, Geun-Shik; Brady, Jillian; Datta, Shrimati; Katan, Matilda; Sheikh, Afzal; Martins, Marta S.; et al. "A Hypermorphic Missense Mutation in PLCG2 , Encoding Phospholipase C¿2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency". The American Journal of Human Genetics 91 4 (2012): 713-720. http://dx.doi.org/10.1016/j.ajhg.2012.08.006.
    10.1016/j.ajhg.2012.08.006
  21. Martins, M.; Warren, S.; Kimberley, C.; Margineanu, A.; Peschard, P.; McCarthy, A.; Yeo, M.; et al. "Activity of PLC  contributes to chemotaxis of fibroblasts towards PDGF". Journal of Cell Science 125 23 (2012): 5758-5769. http://dx.doi.org/10.1242/jcs.110007.
    10.1242/jcs.110007
  22. Ombrello, M.J.; Remmers, E.F.; Sun, G.; Freeman, A.F.; Datta, S.; Torabi-Parizi, P.; Subramanian, N.; et al. "Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions". New England Journal of Medicine 366 4 (2012): 330-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863030888&partnerID=MN8TOARS.
    10.1056/NEJMoa1102140
  23. Bunney, T.D.; Esposito, D.; Mas-Droux, C.; Lamber, E.; Baxendale, R.W.; Martins, M.; Cole, A.; et al. "Structural and functional integration of the PLCg interaction domains critical for regulatory mechanisms and signaling deregulation". Structure 20 12 (2012): 2062-2075. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870534658&partnerID=MN8TOARS.
    10.1016/j.str.2012.09.005
  24. Martins, Marta; Dairou, Julien; Rodrigues-Lima, Fernando; Dupret, Jean-Marie; Silar, Philippe. "Insights into the Phylogeny or Arylamine N-Acetyltransferases in Fungi". Journal of Molecular Evolution 71 2 (2010): 141-152. http://dx.doi.org/10.1007/s00239-010-9371-x.
    10.1007/s00239-010-9371-x
  25. Martins, Marta; Rodrigues-Lima, Fernando; Dairou, Julien; Lamouri, Aazdine; Malagnac, Fabienne; Silar, Philippe; Dupret, Jean-Marie. "An Acetyltransferase Conferring Tolerance to Toxic Aromatic Amine Chemicals". Journal of Biological Chemistry 284 28 (2009): 18726-18733. http://dx.doi.org/10.1074/jbc.m109.015230.
    10.1074/jbc.m109.015230
  26. Ragunathan, Nilusha. "Human arylamine N-acetyltransferase 1 (NAT1) as a target of chemotherapeutic drugs in breast cancer: cisplatin as a model". Molecular and Cellular Pharmacology 1 1 (2009): 7-10. http://dx.doi.org/10.4255/mcpharmacol.09.02.
    10.4255/mcpharmacol.09.02
  27. Martins, Marta; Pluvinage, Benjamin; de la Sierra-Gallay, Inès Li; Barbault, Florent; Dairou, Julien; Dupret, Jean-Marie; Rodrigues-Lima, Fernando. "Functional and Structural Characterization of the Arylamine N-Acetyltransferase from the Opportunistic Pathogen Nocardia farcinica". Journal of Molecular Biology 383 3 (2008): 549-560. http://dx.doi.org/10.1016/j.jmb.2008.08.035.
    10.1016/j.jmb.2008.08.035
  28. Ragunathan, Nilusha; Dairou, Julien; Pluvinage, Benjamin; Martins, Marta; Petit, Emile; Janel, Nathalie; Dupret, Jean-Marie; Rodrigues-Lima, Fernando. "Identification of the Xenobiotic-Metabolizing Enzyme Arylamine N-Acetyltransferase 1 as a New Target of Cisplatin in Breast Cancer Cells: Molecular and Cellular Mechanisms of Inhibition". Molecular Pharmacology 73 6 (2008): 1761-1768. http://dx.doi.org/10.1124/mol.108.045328.
    10.1124/mol.108.045328
  29. Pluvinage, Benjamin; Li de la Sierra-Gallay, Inés; Martins, Marta; Ragunathan, Nilusha; Dupret, Jean-Marie; Rodrigues-Lima, Fernando. "Crystallization and preliminary X-ray characterization of arylamineN-acetyltransferase C (BanatC) fromBacillus anthracis". Acta Crystallographica Section F Structural Biology and Crystallization Communications 63 10 (2007): 862-864. http://dx.doi.org/10.1107/s1744309107041814.
    10.1107/s1744309107041814
  30. Atmane, Noureddine; Dairou, Julien; Flatters, Delphine; Martins, Marta; Pluvinage, Benjamin; Derreumaux, Philippe; Dupret, Jean-Marie; Rodrigues-Lima, Fernando. "The conserved glycine/alanine residue of the active-site loop containing the putative acetylCoA-binding motif is essential for the overall structural integrity of Mesorhizobium loti arylamine N-acetyltransferase 1". Biochemical and Biophysical Research Communications 361 1 (2007): 256-262. http://dx.doi.org/10.1016/j.bbrc.2007.07.034.
    10.1016/j.bbrc.2007.07.034
  31. Pluvinage, Benjamin; Dairou, Julien; Possot, Odile M.; Martins, Marta; Fouet, Agnès; Dupret, Jean-Marie; Rodrigues-Lima, Fernando. "Cloning and Molecular Characterization of Three ArylamineN-Acetyltransferase Genes fromBacillus anthracis:  Identification of Unusual Enzymatic Properties and Their Contribution to Sulfamethoxazole Resistance†". Biochemistry 46 23 (2007): 7069-7078. http://dx.doi.org/10.1021/bi700351w.
    10.1021/bi700351w
Journal issue
  1. João Pessoa; Marta Martins; Sandra Casimiro; Carlos Pérez-Plasencia; Varda Shoshan-Barmatz. "Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets". Frontier in Oncology (2022):
    Published
Thesis / Dissertation
  1. Martins, Marta. "Characterization of arylamine N-acetyltransferases enzymes from Podospora anserina filamentous fungus and Nocardia farcinica bacterium: Environmental and Therapeutic Implication". PhD, Université Paris Diderot, 2008.
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/09/01 - Current EGFR/SHP2-targeted nanomedicines for colorectal cancer theranostic
Co-supervisor
Theranostics (PhD)
Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Gulbenkian Institute for Molecular Medicine, Portugal
2023/05/01 - Current Therapeutic Properties of Deflamin in a Mouse Model of Colitis-associated Colorectal Cancer
Supervisor
Oncobiology (Master)
Gulbenkian Institute for Molecular Medicine, Portugal
2024/09/01 - 2025/05/01 Expressão de PLCy1 em células tumorais circulantes como biomarcador de respostas do cetuximab em cancro colorretal metastático
Supervisor
MEEM (Degree)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2023/09/01 - 2024/12/18 PLCy1: Tumour suppressor or oncogene in triple negative breast cancer
Supervisor
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2022/09/01 - 2024/05/31 Predictive markers of immunotherapy resistance in lung cancer
Supervisor
Master (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024 - 2024/05/01 Phospholipase C gamma 1 (PLCy1) in patients with colorectal cancer resistant to cetuximab
Supervisor
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2022/09/01 - 2023/12/11 From cells to mice: Investigating the role of PLCy1 intriple negative breast cancer
Supervisor
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09/01 - 2023/11/21 Clinical Impact of Hight Throughput Molecular Data in Sarcomas Patient Care
Supervisor
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09/01 - 2023/10/27 Prognostic significance of PLCg1 in Luminal A Breast Cancer: insights into cell cycle regulation and estrogen signalling
Supervisor
master (Master)
Universidade de Coimbra, Portugal
2018/11/01 - 2023/10/23 Phospholipase C signalling in resistance to anti-RTK therapy
Supervisor
Instituto de Medicina Molecular, Portugal
2022/07/01 - 2022/08/31 Establishment of a ER-reporter in luminal A Breast Cancer
Supervisor
ERASMUS STUDENT (Degree)
Universite Paris 6 Faculte de Medecine Site Saint-Antoine, France
2021/09/01 - 2022/06/27 Breast of you: Inter-tumour heterogeneity of Breast Cancer and it´s follow-up through ctDNA sequencing
Supervisor
Breast Cancer ctDNA analysis (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020/09/01 - 2022/02/23 Action mechanisms of deflamin in the treatment of colorectal cancer
Supervisor
Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2018 - 2020 In vitro and in vivo activities of an MMP-9 inhibitory protein isolated from Lupinus albus seeds against colon adenocarcinoma
Co-supervisor
Oncobiology (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/09 - 2018/09 Alternative Splicing of EXOC7 in Colorectal Cancer Development
Supervisor
Biomedicine and Molecular Genetics (Master)
Universidade Nova de Lisboa, Portugal
2017 - 2018 PLCE1 rs2274223 A/G polymorphism and its functional role in Colorectal Cancer
Supervisor
Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2017 Study PLCe SNP rs2274223 in a Portuguese population of colorectal cancer patients
Supervisor
Medicine (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2016 Role of PLCgamma1 in the Resistance Mechanism to Anti-EGFR Therapy in Metastatic Colorectal Cancer
Supervisor
Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2025/04/21 - 2025/05/02 Guest speaker at XXIV Fórum Educacional - Do DNA ao Medicamento: O Impacto da Farmacogenómica na Saúde Moderna. "Farmacogenómica aplicada à oncologia: desafios e oportunidades."
Symposium
XXIV Fórum Educacional - Do DNA ao Medicamento: O Impacto da Farmacogenómica na Saúde Moderna
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/10/14 - 2024/10/18 Guest speaker at Advanced Course on Molecular Biomarkers and Technologies. "Identifying Patients for Targeted Therapies in Oncology."
Workshop
Advanced Course - Molecular Biomarkers and Technologies
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/07/24 - 2022/07/29 Guest Speaker at the IX Cell Culture and Tissue Training Course from Centre of Investigation on Environment, Genetics and Oncobiology (CIMAGO)
Symposium
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2024/12/09 Exploring the crosstalk between Sialyl-Tn (STn) expression and Pancreatic ductal adenocarcinoma (PDAC) progression
(Thesis) Main arguer
Ana Carolina Soares (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/12/04 Zebrafish Avatars to forecast hormone therapy responses in Breast Cancer
(Thesis) Main arguer
Salvador Ferreira (Master)
Universidade Nova de Lisboa Medical School, Portugal
2023/01/18 Deflamin, an edible anti-inflammatory and anticancer protein isolated from legume seeds
(Thesis) Arguer
Joana Mota (PhD)
Universidade de Lisboa Instituto Superior de Agronomia, Portugal
2022/07/15 The Impact of High LDL on HER2+ Breast Cancer Aggressiveness and Sensitivity to Trastuzumab
(Thesis) Main arguer
Sónia Caldas (Other)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/09/10 The anti-oncogenic role of stromal p53 in colorectal cancer
(Thesis) Main arguer
Sofia Martins (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020/03 The metastatic spectrum: oligometastasis versus polimetastasis
(Thesis) Main arguer
Rita de Almeida Carvalho (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 Influência da microbiota intestinal na resposta aos anti-PD1
(Thesis) Main arguer
Carlota de Oliveira Damas Mora (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/05 Immunogenicity of Colorectal Cancer with Microsatellite Instability
(Thesis) Main arguer
Inês do Vale Costa Santos (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 The DNA damage response in terminally differentiated skeletal myotubes
(Thesis) Main arguer
Ana Isabel Afonso Duarte (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2019 - Current European Association for Cancer Research
2019 - Current ASPIC: Associação Portuguesa de Investigação em Cancro

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09/01 - Current Biochemistry - Instituto Politécnico Universidade Lusófona/Veterinary Medical School Lusófona (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2023 - Current Assistant Teacher - Oncobiology at Medical School (Licenciatura) Universidade de Lisboa, Portugal
2013 - 2013 Lead Tutor at Lab Techniques of Mammalian Cell Biology Course at University College London (Bachelor) University College London Faculty of Life Sciences, United Kingdom
2012 - 2013 Assistant Teacher in Cellular and Molecular Biology Course at University College London (Bachelor) University College London Division of Biosciences, United Kingdom

Journal scientific committee

Journal title (ISSN) Publisher
2023 - 2024 Signaling Pathways of Breast Cancer. Cancers
2022/12/01 - 2023/03/31 Tumor Microenvironment: New Challenges and Opportunities, Biomedicines
2021/06 - 2022/05 Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets Frontiers in Oncology
Distinctions

Award

2019 Second Best PhD thesis - Anual FMUL PhD meeting
Gulbenkian Institute for Molecular Medicine Oeiras Site, Portugal
2016 Supervisor of the Third Best Master Thesis
Instituto de Medicina Molecular, Portugal
2015 Merit Award by GICD/Bayer
2014 Investigador FCT Program
Fundação para a Ciência e a Tecnologia, Portugal
2009 Postdoctoral Fellowship
Cancer Research UK, United Kingdom
2005 PhD Fellowship
Fondation pour la Recherche Médicale, France