Identification
Personal identification
- Full name
- Marta Sofia Alves Martins
Citation names
- Martins, Marta
Author identifiers
- Ciência ID
- 8310-DA72-78B6
- ORCID iD
- 0000-0003-0429-9380
- Google Scholar ID
- https://scholar.google.com/citations?hl=en&user=OwVOulgAAAAJ
- Researcher Id
- A-9905-2013
- Scopus Author Id
- 55268246400
Email addresses
- marta.martins@medicina.ulisboa.pt (Professional)
Addresses
- Instituto de Medicina Molecular. Av. Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)
Websites
- https://scholar.google.com/citations?hl=en&user=OwVOulgAAAAJ (Professional)
Knowledge fields
- Natural sciences - Biological Sciences
- Medical and Health Sciences - Basic Medicine
- Natural sciences - Biological Sciences - Biology
- Natural sciences - Biological Sciences - Cell Biology
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
Portuguese (Mother tongue) | |||||
French | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) |
English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) |
Education
Degree | Classification | |
---|---|---|
2023/05/01 - 2023/05/05
Concluded
|
Course on Laboratory Animal Science for Functions A + B +C. (Curso de Especialização Tecnológica)
Gulbenkian Institute for Molecular Medicine, Portugal
|
|
2017 - 2017
Concluded
|
Personal Licence for Scientific Procedures in Living Animals (Curso de Especialização Tecnológica)
Instituto de Medicina Molecular, Portugal
|
|
2009 - 2009
Concluded
|
Personal Licence for Scientific Procedures in Living Animals (Postgraduate Certificate)
Institute of Cancer Research Division of Cancer Biology, United Kingdom
|
|
2005/09/01 - 2008/12/08
Concluded
|
Structure, Function and Engineering of Proteins (Doctorat)
Major in Biochemistry and Molecular Biology
Université Paris Diderot, France
"Characterization of arylamine N-acetyltransferases enzymes from Podospora anserina filamentous fungus and Nocardia farcinica
bacterium: Environmental and Therapeutic Implication" (THESIS/DISSERTATION)
|
With honours |
2005
Concluded
|
Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
""Anti-proliferative activity of CCN3 enzyme in fibroblasts" - ERASMUS Student in Université Paris 7- France " (THESIS/DISSERTATION)
|
14/20 |
2001
Concluded
|
Ciências (Ensino secundário)
Escola Secundária Rodrigues de Freitas, Portugal
|
18,84 |
Affiliation
Teaching in Higher Education
Category Host institution |
Employer | |
---|---|---|
2023/09/01 - Current | Assistant Professor (University Teacher) | Ensino Lusófona, Portugal |
Universidade Lusófona de Humanidades e Tecnologias Faculdade de Medicina Veterinária, Portugal |
Others
Category Host institution |
Employer | |
---|---|---|
2024 - Current | Assistant Researcher- Multi-Cancer Profile Project | Gulbenkian Institute for Molecular Medicine, Portugal |
2022/04 - 2024/03 | Auxiliary Researcher- Deflamin beverages against colorectal cancer | Instituto de Medicina Molecular, Portugal |
2020 - 2022 | Assistant Researcher- Multi-Cancer Profile Project | Instituto de Medicina Molecular, Portugal |
2015/02/01 - 2020 | Assistant Researcher- Investigador FCT (IF/00409/2014) | Instituto de Medicina Molecular, Portugal |
Instituto de Medicina Molecular, Portugal | ||
2014/04/01 - 2015/02/01 | Postdoctoral studies in Cancer Biology Subject: “Mechanisms and relevance of Phospholipase C epsilon downregulation in Colorectal cancer.” Supervisor: Prof. Luis Costa. FCT funded project. | Instituto de Medicina Molecular, Portugal |
2013/09/01 - 2014/03/31 | Postdoctoral studies in Cancer Biology Subject: “Creating new cell lines of flies to be used as a model of intestinal cancer.” Supervisor: Dr. Ivana Bjedov. ERC funded project. | University College London Cancer Institute, United Kingdom |
2009/01/01 - 2013/12/31 | Post-doctoral studies in Cellular and Molecular Biology focusing on the role of Phospholipase C epsilon, an effector protein of the oncogene Ras, in cancer mouse models. CRUK funded project | Institute of Cancer Research Division of Cancer Biology, United Kingdom |
2013/03/01 - 2013/08/31 | Post-doctoral studies in Structural and Molecular Biology- "Functional and structural characterization of von Willebrand factor mutations in patients with blood disease". Supervisor: Flemming Hansen. | University College London, United Kingdom |
2006/01/01 - 2008/12/31 | Doctorat- “Role of arylamine N-acetyltransferases enzymes from Podospora anserina and Nocardia farcinica: Environmental and Therapeutic Implication”- French Ministry Fellowship | Université Paris Diderot, France |
Projects
Grant
Designation | Funders | |
---|---|---|
2025 - 2027 | Development of a clinical decision support tool to predict disease progression in patients with metastatic breast cancer.
2024.07424.IACDC
Researcher
|
Ongoing
|
2025/09/01 - 2026/08/31 | Sarcoma Clinical Data Integration with AI-Driven Automation for the National Oncology Registry
2024.07252.IACDC
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2023 - 2026 | Innovative approaches for pancreatic cancer: Decoding and manipulating the immune response to sialylated O-glycans.
2022.04607.PTDC
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2023/04/15 - 2024 | PLCy1 expression in circulating tumour cells as a new biomarker of cetuximab responses in metastatic colorrectal cancer
João e Natália
Principal investigator
Instituto de Medicina Molecular, Portugal
|
Liga Portuguesa Contra o Cancro
Ongoing
|
2018/11/01 - 2022/10/31 | Phospholipase C signalling in resistance to anti-RTK therapy
SFRH/BD/139138/2018
Supervisor
Fundação para a Ciência e a Tecnologia, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2018 - 2019 | Predictive role of PLCg1 in cetuximab responses
FPJ885
Principal investigator
Instituto de Medicina Molecular, Portugal
|
Instituto de Medicina Molecular
Concluded
|
2017 - 2018 | Study PLCe SNP rs2274223 in a Portuguese population of colorectal cancer patients
GAPIC 201780607
Supervisor
Universidade de Lisboa, Portugal
|
Universidade de Lisboa
Concluded
|
2016 - 2018 | Involvement of PLCg1 in the Resistance Mechanism to anti-EGFR therapy in Metastatic Colorectal Cancer
LPCC-NRS/Terry Fox 2016-2017
Principal investigator
Instituto de Medicina Molecular, Portugal
|
Liga Portuguesa Contra o Cancro
Concluded
|
2014/04/01 - 2015/03/31 | Mechanisms and relevance of Phospholipase C epsilon downregulations in colorectal cancer
EXPL/BIM-ONC/1048/2013
Principal investigator
Instituto de Medicina Molecular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
Contract
Designation | Funders | |
---|---|---|
2021/01/01 - 2025/12/31 | Instituto de Medicina Molecular João Lobo Antunes
LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2022/02/01 - 2024/02/01 | Development of lupine and ckickpea-based beverages as functional food against colorectal cancer
PTDC/OCE-ETA/4836/2021
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2020/02/01 - 2022/01/01 | Multi-Cancer Profile Project
MCPP
Researcher
Instituto de Medicina Molecular, Portugal
|
Merk Serono
Concluded
|
2015/02/01 - 2020/01/31 | Role of Phospholipase C epsilon as a Biomarker of Colorectal Cancer Progression
IF/00409/2014
Principal investigator
Instituto de Medicina Molecular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2019/01/01 - 2019/12/31 | Instituto de Medicina Molecular - IMM
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2009 - 2013 | Phospholipase C epsilon role in cancer mouse models
contract
Researcher
Institute of Cancer Research Chester Beatty Laboratories, United Kingdom
|
Cancer Research UK
Concluded
|
2005/10/01 - 2008/09/30 | Role of arylamine N-acetyltransferases enzymes from Podospora anserina filamentous fungus and Nocardia farcinica bacterium:
Environmental and Therapeutic Implication
French Ministry of l'Enseignement supérieur de la Recherche et de l'Innovation
PhD Student Fellow
Université Paris Diderot, France
|
Gouvernement francais Ministère de l'Enseignement supérieur de la Recherche et de l'Innovation
Concluded
|
Outputs
Publications
Book chapter |
|
Conference abstract |
|
Conference poster |
|
Journal article |
|
Journal issue |
|
Thesis / Dissertation |
|
Activities
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2023/09/01 - Current | EGFR/SHP2-targeted nanomedicines for colorectal cancer theranostic
Co-supervisor
|
Theranostics (PhD)
Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal Gulbenkian Institute for Molecular Medicine, Portugal |
2023/05/01 - Current | Therapeutic Properties of Deflamin in a Mouse Model of Colitis-associated Colorectal Cancer
Supervisor
|
Oncobiology (Master)
Gulbenkian Institute for Molecular Medicine, Portugal
|
2024/09/01 - 2025/05/01 | Expressão de PLCy1 em células tumorais circulantes como biomarcador de respostas do cetuximab em cancro colorretal metastático
Supervisor
|
MEEM (Degree)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
|
2023/09/01 - 2024/12/18 | PLCy1: Tumour suppressor or oncogene in triple negative breast cancer
Supervisor
|
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
|
2022/09/01 - 2024/05/31 | Predictive markers of immunotherapy resistance in lung cancer
Supervisor
|
Master (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
|
2024 - 2024/05/01 | Phospholipase C gamma 1 (PLCy1) in patients with colorectal cancer resistant to cetuximab
Supervisor
|
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
|
2022/09/01 - 2023/12/11 | From cells to mice: Investigating the role of PLCy1 intriple negative breast cancer
Supervisor
|
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
|
2022/09/01 - 2023/11/21 | Clinical Impact of Hight Throughput Molecular Data in Sarcomas Patient Care
Supervisor
|
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
|
2022/09/01 - 2023/10/27 | Prognostic significance of PLCg1 in Luminal A Breast Cancer: insights into cell cycle regulation and estrogen signalling
Supervisor
|
master (Master)
Universidade de Coimbra, Portugal
|
2018/11/01 - 2023/10/23 | Phospholipase C signalling in resistance to anti-RTK therapy
Supervisor
|
Instituto de Medicina Molecular, Portugal
|
2022/07/01 - 2022/08/31 | Establishment of a ER-reporter in luminal A Breast Cancer
Supervisor
|
ERASMUS STUDENT (Degree)
Universite Paris 6 Faculte de Medecine Site Saint-Antoine, France
|
2021/09/01 - 2022/06/27 | Breast of you: Inter-tumour heterogeneity of Breast Cancer and it´s follow-up through ctDNA sequencing
Supervisor
|
Breast Cancer ctDNA analysis (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2020/09/01 - 2022/02/23 | Action mechanisms of deflamin in the treatment of colorectal cancer
Supervisor
|
Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
|
2018 - 2020 | In vitro and in vivo activities of an MMP-9 inhibitory protein isolated from Lupinus albus seeds against colon adenocarcinoma
Co-supervisor
|
Oncobiology (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2017/09 - 2018/09 | Alternative Splicing of EXOC7 in Colorectal Cancer Development
Supervisor
|
Biomedicine and Molecular Genetics (Master)
Universidade Nova de Lisboa, Portugal
|
2017 - 2018 | PLCE1 rs2274223 A/G polymorphism and its functional role in Colorectal Cancer
Supervisor
|
Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2017 - 2017 | Study PLCe SNP rs2274223 in a Portuguese population of colorectal cancer patients
Supervisor
|
Medicine (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2015 - 2016 | Role of PLCgamma1 in the Resistance Mechanism to Anti-EGFR Therapy in Metastatic Colorectal Cancer
Supervisor
|
Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
Event participation
Activity description Type of event |
Event name Institution / Organization |
|
---|---|---|
2025/04/21 - 2025/05/02 | Guest speaker at XXIV Fórum Educacional - Do DNA ao Medicamento: O Impacto da Farmacogenómica na Saúde Moderna. "Farmacogenómica
aplicada à oncologia: desafios e oportunidades."
Symposium
|
XXIV Fórum Educacional - Do DNA ao Medicamento: O Impacto da Farmacogenómica na Saúde Moderna
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2024/10/14 - 2024/10/18 | Guest speaker at Advanced Course on Molecular Biomarkers and Technologies. "Identifying Patients for Targeted Therapies in
Oncology."
Workshop
|
Advanced Course - Molecular Biomarkers and Technologies
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2022/07/24 - 2022/07/29 | Guest Speaker at the IX Cell Culture and Tissue Training Course from Centre of Investigation on Environment, Genetics and
Oncobiology (CIMAGO)
Symposium
|
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia, Portugal
|
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2024/12/09 | Exploring the crosstalk between Sialyl-Tn (STn) expression and Pancreatic ductal adenocarcinoma (PDAC) progression
(Thesis) Main arguer
|
Ana Carolina Soares (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
|
2024/12/04 | Zebrafish Avatars to forecast hormone therapy responses in Breast Cancer
(Thesis) Main arguer
|
Salvador Ferreira (Master)
Universidade Nova de Lisboa Medical School, Portugal
|
2023/01/18 | Deflamin, an edible anti-inflammatory and anticancer protein isolated
from legume seeds
(Thesis) Arguer
|
Joana Mota (PhD)
Universidade de Lisboa Instituto Superior de Agronomia, Portugal
|
2022/07/15 | The Impact of High LDL on HER2+ Breast Cancer Aggressiveness
and Sensitivity to Trastuzumab
(Thesis) Main arguer
|
Sónia Caldas (Other)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2021/09/10 | The anti-oncogenic role of stromal p53 in colorectal cancer
(Thesis) Main arguer
|
Sofia Martins (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2020/03 | The metastatic spectrum: oligometastasis versus polimetastasis
(Thesis) Main arguer
|
Rita de Almeida Carvalho (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2019 | Influência da microbiota intestinal na resposta aos anti-PD1
(Thesis) Main arguer
|
Carlota de Oliveira Damas Mora (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2017/05 | Immunogenicity of Colorectal Cancer with Microsatellite Instability
(Thesis) Main arguer
|
Inês do Vale Costa Santos (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
2017 | The DNA damage response in terminally differentiated skeletal myotubes
(Thesis) Main arguer
|
Ana Isabel Afonso Duarte (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
Association member
Society Organization name | Role | |
---|---|---|
2019 - Current | European Association for Cancer Research | |
2019 - Current | ASPIC: Associação Portuguesa de Investigação em Cancro |
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2023/09/01 - Current | Biochemistry - Instituto Politécnico Universidade Lusófona/Veterinary Medical School Lusófona | (Licenciatura) | Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal |
2023 - Current | Assistant Teacher - Oncobiology at Medical School | (Licenciatura) | Universidade de Lisboa, Portugal |
2013 - 2013 | Lead Tutor at Lab Techniques of Mammalian Cell Biology Course at University College London | (Bachelor) | University College London Faculty of Life Sciences, United Kingdom |
2012 - 2013 | Assistant Teacher in Cellular and Molecular Biology Course at University College London | (Bachelor) | University College London Division of Biosciences, United Kingdom |
Journal scientific committee
Journal title (ISSN) | Publisher | |
---|---|---|
2023 - 2024 | Signaling Pathways of Breast Cancer. | Cancers |
2022/12/01 - 2023/03/31 | Tumor Microenvironment: New Challenges and Opportunities, | Biomedicines |
2021/06 - 2022/05 | Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets | Frontiers in Oncology |
Distinctions
Award
2019 | Second Best PhD thesis - Anual FMUL PhD meeting
Gulbenkian Institute for Molecular Medicine Oeiras Site, Portugal
|
2016 | Supervisor of the Third Best Master Thesis
Instituto de Medicina Molecular, Portugal
|
2015 | Merit Award by GICD/Bayer |
2014 | Investigador FCT Program
Fundação para a Ciência e a Tecnologia, Portugal
|
2009 | Postdoctoral Fellowship
Cancer Research UK, United Kingdom
|
2005 | PhD Fellowship
Fondation pour la Recherche Médicale, France
|